Protective Effects of Ethanolic Purslane Extracts on Doxorubicin-Induced Hepatotoxicity in Albino Rats

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publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">Protective Effects of Ethanolic Purslane Extracts on Doxorubicin-Induced Hepatotoxicity in Albino Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Osama%20M.%20Ahmed">Osama M. Ahmed</a>, <a href="https://publications.waset.org/abstracts/search?q=Walaa%20G.%20Hozayen"> Walaa G. Hozayen</a>, <a href="https://publications.waset.org/abstracts/search?q=Haidy%20Tamer%20Abo%20Sree"> Haidy Tamer Abo Sree</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The effect of doxorubicin (4 mg/kg b.w.week) without or with oral administration of ethanolic purslane (Portulaca oleracea) shoot (leaves and stems) extract (50 mg/kg b.w.day) or ethanolic purslane seeds extract (50 mg/kg b.w.day) co-treatments for 6 weeks was evaluated in adult male rats. There was an increase in serum levels of ALT, AST, ALP, GGT and total bilirubin. In addition, hepatic glutathine, glutathione transferase, peroxidase, SOD, CAT activities were decreased while lipid peroxidation in the liver was increased. Co-administration of ethanolic purslane and seed extracts successfully improved the adverse changes in the liver functions with an increase in antioxidants activities and reduction of lipid peroxidation. <iframe src="https://publications.waset.org/abstracts/30941.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antioxidants" title="antioxidants">antioxidants</a>, <a href="https://publications.waset.org/abstracts/search?q=doxorubicin" title=" doxorubicin"> doxorubicin</a>, <a href="https://publications.waset.org/abstracts/search?q=hepatotoxicity" title=" hepatotoxicity"> hepatotoxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=purslane" title=" purslane"> purslane</a> </p> <a href="https://publications.waset.org/abstracts/30941/protective-effects-of-ethanolic-purslane-extracts-on-doxorubicin-induced-hepatotoxicity-in-albino-rats" class="btn 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Protective Effects of Ethanolic Purslane Extracts on Doxorubicin-Induced Hepatotoxicity in Albino Rats