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class="menu-item search"><a href="#" class="search-toggle"><i class="icon-search"></i></a></li></ul></div></nav><div class="archive-intro"><div class="wrap"><h1 class="archive-title"><span>Supply Chain</span></h1></div></div><div class="site-inner"><div class="wrap"><div class="content-sidebar-wrap"><main class="content"><article class="type-post entry has-post-thumbnail" aria-label="Sanofi to invest €40 million to boost antibody production in France"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/cnewmarker/" class="entry-author-link" rel="author"><span class="entry-author-name">Chris Newmarker</span></a></span> | <time class="entry-time">November 19, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/sanofi-to-invest-e40-million-to-boost-antibody-production-in-france/">Sanofi to invest €40 million to boost antibody production in France</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/sanofi-to-invest-e40-million-to-boost-antibody-production-in-france/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2022/03/Sanofi-Logo-Video-Still-2-268x170.jpg" class="alignleft post-image entry-image wp-image-15160" alt="Sanofi logo" decoding="async" /></a><p>Sanofi recently announced that it is investing €40 million in its Lyon Gerland bioproduction site as it seeks to bolster its position in the immunology space. The investment will support production in France of the transplant drug Thymoglubulin, including €25 million toward developing and manufacturing a second-generation version of the drug. The remaining €15 million…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="Otsuka partners with ICU Medical to enter U.S. IV products market"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/cnewmarker/" class="entry-author-link" rel="author"><span class="entry-author-name">Chris Newmarker</span></a></span> | <time class="entry-time">November 13, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/otsuka-partners-with-icu-medical-to-enter-u-s-iv-products-market/">Otsuka partners with ICU Medical to enter U.S. IV products market</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/otsuka-partners-with-icu-medical-to-enter-u-s-iv-products-market/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/11/Otsuka-ICU-Medical-268x170.png" class="alignleft post-image entry-image wp-image-16495" alt="These are the logos of Otsuka Medical and ICU Medical." decoding="async" loading="lazy" /></a><p>Otsuka Holdings will pay ICU Medical (Nasdaq: ICUI) an upfront payment of $200 million as part of a joint venture to enter the U.S. IV products market, which has been facing hurricane-related shortages this fall. The partnership — which involves ICU Medical providing commercial services for Otsuka’s Otsuka Pharmaceutical Factory (OPF) subsidiary — also includes…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="Baxter exits China IV products market, focuses on U.S. shortages"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/cnewmarker/" class="entry-author-link" rel="author"><span class="entry-author-name">Chris Newmarker</span></a></span> | <time class="entry-time">November 5, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/baxter-exits-china-iv-products-market-to-better-focus-on-u-s-shortages/">Baxter exits China IV products market, focuses on U.S. shortages</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/baxter-exits-china-iv-products-market-to-better-focus-on-u-s-shortages/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2020/11/baxter-268x170.png" class="alignleft post-image entry-image wp-image-14020" alt="Baxter logo" decoding="async" loading="lazy" /></a><p>Baxter recently stopped selling IV products in China as it continues its efforts to address hurricane-related supply shortages in the U.S. In a statement shared with Pharmaceutical Processing World, the Deerfield, Illinois–based company said: “After careful consideration, and given the numerous alternative IV solution suppliers that exist in the Chinese market, Baxter has suspended commercial…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="MilliporeSigma invests $76M to expand cancer therapy manufacturing"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/swhooley/" class="entry-author-link" rel="author"><span class="entry-author-name">Sean Whooley</span></a></span> | <time class="entry-time">October 31, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/milliporesigma-invests-76m-to-expand-cancer-therapy-manufacturing/">MilliporeSigma invests $76M to expand cancer therapy manufacturing</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/milliporesigma-invests-76m-to-expand-cancer-therapy-manufacturing/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/10/MilliporeSigma-ADC-manufacturing-expansion-1-268x170.jpg" class="alignleft post-image entry-image wp-image-16483" alt="MilliporeSigma ADC manufacturing expansion (1)" decoding="async" loading="lazy" /></a><p>MilliporeSigma, Merck KGaA’s U.S. and Canada Life Science business, announced a $76 million expansion of its ADC manufacturing capabilities and capacity. The company is expanding the capacity at its Bioconjugation Center of Excellence facility in St. Louis. This investment triples existing capacity and enhances the company’s contract development and manufacturing organization (CDMO) offering. MilliporeSigma said…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="BD partners with ten23 health on prefilled syringe manufacturing"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/swhooley/" class="entry-author-link" rel="author"><span class="entry-author-name">Sean Whooley</span></a></span> | <time class="entry-time">October 7, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/bd-ten23-partner-prefilled-syringe-manufacturing/">BD partners with ten23 health on prefilled syringe manufacturing</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/bd-ten23-partner-prefilled-syringe-manufacturing/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/10/BD-ten-23-Health-RFID-prefillable-syringe-manufacturing-268x170.jpg" class="alignleft post-image entry-image wp-image-16464" alt="BD ten23 Health RFID prefillable syringe manufacturing" decoding="async" loading="lazy" /></a><p>BD (NYSE:BDX) announced today that it entered into a collaboration with ten23 health to develop a new way to track prefillable syringes (PFS). ten23 health, a Swiss CDMO, offers drug development, filling and device assembly expertise to contribute to the product offering. It recently entered into a production collaboration with on-body drug delivery device maker…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="J&J invest $2B to build new manufacturing facility in North Carolina"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/dkirsh/" class="entry-author-link" rel="author"><span class="entry-author-name">Danielle Kirsh</span></a></span> | <time class="entry-time">October 7, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/jj-invest-2b-to-build-new-manufacturing-facility-in-north-carolina/">J&J invest $2B to build new manufacturing facility in North Carolina</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/jj-invest-2b-to-build-new-manufacturing-facility-in-north-carolina/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/05/Johnson-Johnson-logo-268x170.png" class="alignleft post-image entry-image wp-image-16345" alt="This is the logo of Johnson & Johnson." decoding="async" loading="lazy" /></a><p>Johnson & Johnson recently announced plans to invest more than $2 billion in a new manufacturing facility in North Carolina. The company plans to build a state-of-the-art biologics manufacturing facility in Wilson, North Carolina, to expand the production of its pipeline of innovative biologics. The expansion supports J&J’s broader plan to advance more than 70…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="SK Pharmteco invests $260M to expand small molecule, peptide production"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/swhooley/" class="entry-author-link" rel="author"><span class="entry-author-name">Sean Whooley</span></a></span> | <time class="entry-time">October 2, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/sk-pharmteco-260m-expand-pharma-production/">SK Pharmteco invests $260M to expand small molecule, peptide production</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/sk-pharmteco-260m-expand-pharma-production/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/10/Pharmateco-Footer-Logo-1-268x170.jpg" class="alignleft post-image entry-image wp-image-16461" alt="Pharmateco-Footer-Logo (1)" decoding="async" loading="lazy" /></a><p>SK Pharmteco announced that it expanded its small molecule and peptide production capabilities with a $260 million investment. The Rancho Cordova, California-based CDMO plans to construct a new state-of-the-art facility in Sejong, South Korea. It expects to begin operations at the new plant — the company’s fifth in South Korea — in late 2026. The…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="PCI Pharma Services makes $365M investment in drug delivery device manufacturing"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/swhooley/" class="entry-author-link" rel="author"><span class="entry-author-name">Sean Whooley</span></a></span> | <time class="entry-time">September 25, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/pci-pharma-services-365m-investment-manufacturing/">PCI Pharma Services makes $365M investment in drug delivery device manufacturing</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/pci-pharma-services-365m-investment-manufacturing/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/09/Rockford-IL-Campus-Expansion-PCI-Pharma-Services-1-268x170.jpg" class="alignleft post-image entry-image wp-image-16454" alt="Rockford, IL Campus Expansion - PCI Pharma Services (1)" decoding="async" loading="lazy" /></a><p>PCI Pharma Services announced that it’s investing more than $365 million in infrastructure to support assembly and packaging efforts. The investment supports the clinical- and commercial-scale final assembly and packaging of drug-device combination products utilizing advanced drug delivery systems, with an emphasis on injectable formats. PCI Pharma plans to put its investment toward new and…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="Curium to open new cancer isotope production facility in The Netherlands"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/swhooley/" class="entry-author-link" rel="author"><span class="entry-author-name">Sean Whooley</span></a></span> | <time class="entry-time">September 24, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/curium-open-isotope-production-facility-netherlands/">Curium to open new cancer isotope production facility in The Netherlands</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/curium-open-isotope-production-facility-netherlands/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/09/Curium-Netherlands-facility-opening-1-268x170.jpg" class="alignleft post-image entry-image wp-image-16451" alt="Curium Netherlands facility opening (1)" decoding="async" loading="lazy" /></a><p>Curium announced today that it opened a new facility in Petten, The Netherlands, to produce non-carrier added lutetium-177 (Lu-177). The Paris-based company expanded its capacity to meet the growing global demand for Lu-177 for the treatment of cancer patients. Using in-licensed technology from Turkey-based Eczacıbaşı-Monrol, the facility will initially include two production lines. Curium also…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="BD launches new prefillable syringe, expands platform capacity"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/swhooley/" class="entry-author-link" rel="author"><span class="entry-author-name">Sean Whooley</span></a></span> | <time class="entry-time">September 18, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/bd-launches-prefillable-syringe-expands-capacity/">BD launches new prefillable syringe, expands platform capacity</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/bd-launches-prefillable-syringe-expands-capacity/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/09/BD-Neopak-XtraFlow-glass-prefillable-syringe-1-268x170.jpg" class="alignleft post-image entry-image wp-image-16447" alt="BD Neopak XtraFlow glass prefillable syringe (1)" decoding="async" loading="lazy" /></a><p>BD (NYSE:BDX) announced today that it launched its Neopak XtraFlow glass prefillable syringe and expanded capacity for the platform. The company said the launch and expansion aim to serve the growing market for biologic therapies. Neopak glass prefillable syringes address key development needs for biologic drugs, BD said in a news release. The syringes have…</p> </div><footer class="entry-footer"></footer></article><div class="archive-pagination pagination"><div class="pagination-next alignright"><a href="https://www.pharmaceuticalprocessingworld.com/category/supply-chain/page/2/" class="button">Next ></a></div></div></main><aside class="sidebar sidebar-primary widget-area" role="complementary" aria-label="Primary Sidebar"><section id="custom_html-11" class="widget_text widget widget_custom_html"><div class="widget_text widget-wrap"><div class="textwidget custom-html-widget"><center> <div style="display: flex; flex-direction: column; justify-content: center; width: 300px;"> <div align="center"><a href="https://www.pharmaceuticalprocessingworld.com/sign-up-for-the-pharmaceutical-processing-enewsletter/" target="_blank"><img src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2023/12/PharmaceuticalProcessing-300x100-1.jpg" alt=“ppw newsletter”></a></div> <div align="center" style="width: 300px; 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e({values:Mr(t,e.normalizeUnit),loc:xi.fromObject(n),conversionAccuracy:n.conversionAccuracy})},e.fromDurationLike=function(t){if(or(t))return e.fromMillis(t);if(e.isDuration(t))return t;if("object"==typeof t)return e.fromObject(t);throw new Fn("Unknown duration argument "+t+" of type "+typeof t)},e.fromISO=function(t,n){var r=Mi(t,[Pi,Yi])[0];return r?e.fromObject(r,n):e.invalid("unparsable",'the input "'+t+"\" can't be parsed as ISO 8601")},e.fromISOTime=function(t,n){var r=Mi(t,[ji,oo])[0];return r?e.fromObject(r,n):e.invalid("unparsable",'the input "'+t+"\" can't be parsed as ISO 8601")},e.invalid=function(t,n){if(void 0===n&&(n=null),!t)throw new Fn("need to specify a reason the Duration is invalid");var r=t instanceof Hr?t:new Hr(t,n);if(li.throwOnInvalid)throw new In(r);return new e({invalid:r})},e.normalizeUnit=function(e){var t={year:"years",years:"years",quarter:"quarters",quarters:"quarters",month:"months",months:"months",week:"weeks",weeks:"weeks",day:"days",days:"days",hour:"hours",hours:"hours",minute:"minutes",minutes:"minutes",second:"seconds",seconds:"seconds",millisecond:"milliseconds",milliseconds:"milliseconds"}[e?e.toLowerCase():e];if(!t)throw new Cn(e);return t},e.isDuration=function(e){return e&&e.isLuxonDuration||!1};var t=e.prototype;return t.toFormat=function(e,t){void 0===t&&(t={});var n=gn({},t,{floor:!1!==t.round&&!1!==t.floor});return this.isValid?Ur.create(this.loc,n).formatDurationFromString(this,e):"Invalid Duration"},t.toHuman=function(e){var t=this;void 0===e&&(e={});var n=ho.map((function(n){var r=t.values[n];return ir(r)?null:t.loc.numberFormatter(gn({style:"unit",unitDisplay:"long"},e,{unit:n.slice(0,-1)})).format(r)})).filter((function(e){return e}));return this.loc.listFormatter(gn({type:"conjunction",style:e.listStyle||"narrow"},e)).format(n)},t.toObject=function(){return this.isValid?gn({},this.values):{}},t.toISO=function(){if(!this.isValid)return null;var e="P";return 0!==this.years&&(e+=this.years+"Y"),0===this.months&&0===this.quarters||(e+=this.months+3*this.quarters+"M"),0!==this.weeks&&(e+=this.weeks+"W"),0!==this.days&&(e+=this.days+"D"),0===this.hours&&0===this.minutes&&0===this.seconds&&0===this.milliseconds||(e+="T"),0!==this.hours&&(e+=this.hours+"H"),0!==this.minutes&&(e+=this.minutes+"M"),0===this.seconds&&0===this.milliseconds||(e+=yr(this.seconds+this.milliseconds/1e3,3)+"S"),"P"===e&&(e+="T0S"),e},t.toISOTime=function(e){if(void 0===e&&(e={}),!this.isValid)return null;var t=this.toMillis();if(t<0||t>=864e5)return null;e=gn({suppressMilliseconds:!1,suppressSeconds:!1,includePrefix:!1,format:"extended"},e);var n=this.shiftTo("hours","minutes","seconds","milliseconds"),r="basic"===e.format?"hhmm":"hh:mm";e.suppressSeconds&&0===n.seconds&&0===n.milliseconds||(r+="basic"===e.format?"ss":":ss",e.suppressMilliseconds&&0===n.milliseconds||(r+=".SSS"));var i=n.toFormat(r);return e.includePrefix&&(i="T"+i),i},t.toJSON=function(){return this.toISO()},t.toString=function(){return this.toISO()},t.toMillis=function(){return this.as("milliseconds")},t.valueOf=function(){return this.toMillis()},t.plus=function(t){if(!this.isValid)return this;for(var n,r=e.fromDurationLike(t),i={},o=Dn(ho);!(n=o()).done;){var s=n.value;(lr(r.values,s)||lr(this.values,s))&&(i[s]=r.get(s)+this.get(s))}return yo(this,{values:i},!0)},t.minus=function(t){if(!this.isValid)return this;var n=e.fromDurationLike(t);return this.plus(n.negate())},t.mapUnits=function(e){if(!this.isValid)return this;for(var t={},n=0,r=Object.keys(this.values);n<r.length;n++){var i=r[n];t[i]=Tr(e(this.values[i],i))}return yo(this,{values:t},!0)},t.get=function(t){return this[e.normalizeUnit(t)]},t.set=function(t){return this.isValid?yo(this,{values:gn({},this.values,Mr(t,e.normalizeUnit))}):this},t.reconfigure=function(e){var t=void 0===e?{}:e,n=t.locale,r=t.numberingSystem,i=t.conversionAccuracy,o={loc:this.loc.clone({locale:n,numberingSystem:r})};return i&&(o.conversionAccuracy=i),yo(this,o)},t.as=function(e){return this.isValid?this.shiftTo(e).get(e):NaN},t.normalize=function(){if(!this.isValid)return this;var e=this.toObject();return function(e,t){mo.reduce((function(n,r){return ir(t[r])?n:(n&&vo(e,t,n,t,r),r)}),null)}(this.matrix,e),yo(this,{values:e},!0)},t.shiftTo=function(){for(var t=arguments.length,n=new Array(t),r=0;r<t;r++)n[r]=arguments[r];if(!this.isValid)return this;if(0===n.length)return this;n=n.map((function(t){return e.normalizeUnit(t)}));for(var i,o,s={},u={},a=this.toObject(),l=Dn(ho);!(o=l()).done;){var c=o.value;if(n.indexOf(c)>=0){i=c;var f=0;for(var d in u)f+=this.matrix[d][c]*u[d],u[d]=0;or(a[c])&&(f+=a[c]);var h=Math.trunc(f);for(var m in s[c]=h,u[c]=(1e3*f-1e3*h)/1e3,a)ho.indexOf(m)>ho.indexOf(c)&&vo(this.matrix,a,m,s,c)}else or(a[c])&&(u[c]=a[c])}for(var y in u)0!==u[y]&&(s[i]+=y===i?u[y]:u[y]/this.matrix[i][y]);return yo(this,{values:s},!0).normalize()},t.negate=function(){if(!this.isValid)return this;for(var e={},t=0,n=Object.keys(this.values);t<n.length;t++){var r=n[t];e[r]=0===this.values[r]?0:-this.values[r]}return yo(this,{values:e},!0)},t.equals=function(e){if(!this.isValid||!e.isValid)return!1;if(!this.loc.equals(e.loc))return!1;for(var t,n=Dn(ho);!(t=n()).done;){var r=t.value;if(i=this.values[r],o=e.values[r],!(void 0===i||0===i?void 0===o||0===o:i===o))return!1}var i,o;return!0},pn(e,[{key:"locale",get:function(){return this.isValid?this.loc.locale:null}},{key:"numberingSystem",get:function(){return this.isValid?this.loc.numberingSystem:null}},{key:"years",get:function(){return this.isValid?this.values.years||0:NaN}},{key:"quarters",get:function(){return this.isValid?this.values.quarters||0:NaN}},{key:"months",get:function(){return this.isValid?this.values.months||0:NaN}},{key:"weeks",get:function(){return this.isValid?this.values.weeks||0:NaN}},{key:"days",get:function(){return this.isValid?this.values.days||0:NaN}},{key:"hours",get:function(){return this.isValid?this.values.hours||0:NaN}},{key:"minutes",get:function(){return this.isValid?this.values.minutes||0:NaN}},{key:"seconds",get:function(){return this.isValid?this.values.seconds||0:NaN}},{key:"milliseconds",get:function(){return this.isValid?this.values.milliseconds||0:NaN}},{key:"isValid",get:function(){return null===this.invalid}},{key:"invalidReason",get:function(){return this.invalid?this.invalid.reason:null}},{key:"invalidExplanation",get:function(){return this.invalid?this.invalid.explanation:null}}]),e}();var go=function(){function e(e){this.s=e.start,this.e=e.end,this.invalid=e.invalid||null,this.isLuxonInterval=!0}e.invalid=function(t,n){if(void 0===n&&(n=null),!t)throw new Fn("need to specify a reason the Interval is invalid");var r=t instanceof Hr?t:new Hr(t,n);if(li.throwOnInvalid)throw new _n(r);return new e({invalid:r})},e.fromDateTimes=function(t,n){var r=gs(t),i=gs(n),o=function(e,t){return e&&e.isValid?t&&t.isValid?t<e?go.invalid("end before start","The end of an interval must be after its start, but you had start="+e.toISO()+" and end="+t.toISO()):null:go.invalid("missing or invalid end"):go.invalid("missing or invalid start")}(r,i);return null==o?new e({start:r,end:i}):o},e.after=function(t,n){var r=po.fromDurationLike(n),i=gs(t);return e.fromDateTimes(i,i.plus(r))},e.before=function(t,n){var r=po.fromDurationLike(n),i=gs(t);return e.fromDateTimes(i.minus(r),i)},e.fromISO=function(t,n){var r=(t||"").split("/",2),i=r[0],o=r[1];if(i&&o){var s,u,a,l;try{u=(s=ps.fromISO(i,n)).isValid}catch(e){u=!1}try{l=(a=ps.fromISO(o,n)).isValid}catch(e){l=!1}if(u&&l)return e.fromDateTimes(s,a);if(u){var c=po.fromISO(o,n);if(c.isValid)return e.after(s,c)}else if(l){var f=po.fromISO(i,n);if(f.isValid)return e.before(a,f)}}return e.invalid("unparsable",'the input "'+t+"\" can't be parsed as ISO 8601")},e.isInterval=function(e){return e&&e.isLuxonInterval||!1};var t=e.prototype;return t.length=function(e){return void 0===e&&(e="milliseconds"),this.isValid?this.toDuration.apply(this,[e]).get(e):NaN},t.count=function(e){if(void 0===e&&(e="milliseconds"),!this.isValid)return NaN;var t=this.start.startOf(e),n=this.end.startOf(e);return Math.floor(n.diff(t,e).get(e))+1},t.hasSame=function(e){return!!this.isValid&&(this.isEmpty()||this.e.minus(1).hasSame(this.s,e))},t.isEmpty=function(){return this.s.valueOf()===this.e.valueOf()},t.isAfter=function(e){return!!this.isValid&&this.s>e},t.isBefore=function(e){return!!this.isValid&&this.e<=e},t.contains=function(e){return!!this.isValid&&(this.s<=e&&this.e>e)},t.set=function(t){var n=void 0===t?{}:t,r=n.start,i=n.end;return this.isValid?e.fromDateTimes(r||this.s,i||this.e):this},t.splitAt=function(){var t=this;if(!this.isValid)return[];for(var n=arguments.length,r=new Array(n),i=0;i<n;i++)r[i]=arguments[i];for(var o=r.map(gs).filter((function(e){return t.contains(e)})).sort(),s=[],u=this.s,a=0;u<this.e;){var l=o[a]||this.e,c=+l>+this.e?this.e:l;s.push(e.fromDateTimes(u,c)),u=c,a+=1}return s},t.splitBy=function(t){var n=po.fromDurationLike(t);if(!this.isValid||!n.isValid||0===n.as("milliseconds"))return[];for(var r,i=this.s,o=1,s=[];i<this.e;){var u=this.start.plus(n.mapUnits((function(e){return e*o})));r=+u>+this.e?this.e:u,s.push(e.fromDateTimes(i,r)),i=r,o+=1}return s},t.divideEqually=function(e){return this.isValid?this.splitBy(this.length()/e).slice(0,e):[]},t.overlaps=function(e){return this.e>e.s&&this.s<e.e},t.abutsStart=function(e){return!!this.isValid&&+this.e==+e.s},t.abutsEnd=function(e){return!!this.isValid&&+e.e==+this.s},t.engulfs=function(e){return!!this.isValid&&(this.s<=e.s&&this.e>=e.e)},t.equals=function(e){return!(!this.isValid||!e.isValid)&&(this.s.equals(e.s)&&this.e.equals(e.e))},t.intersection=function(t){if(!this.isValid)return this;var n=this.s>t.s?this.s:t.s,r=this.e<t.e?this.e:t.e;return n>=r?null:e.fromDateTimes(n,r)},t.union=function(t){if(!this.isValid)return this;var n=this.s<t.s?this.s:t.s,r=this.e>t.e?this.e:t.e;return e.fromDateTimes(n,r)},e.merge=function(e){var t=e.sort((function(e,t){return e.s-t.s})).reduce((function(e,t){var n=e[0],r=e[1];return r?r.overlaps(t)||r.abutsStart(t)?[n,r.union(t)]:[n.concat([r]),t]:[n,t]}),[[],null]),n=t[0],r=t[1];return r&&n.push(r),n},e.xor=function(t){for(var n,r,i=null,o=0,s=[],u=t.map((function(e){return[{time:e.s,type:"s"},{time:e.e,type:"e"}]})),a=Dn((n=Array.prototype).concat.apply(n,u).sort((function(e,t){return e.time-t.time})));!(r=a()).done;){var l=r.value;1===(o+="s"===l.type?1:-1)?i=l.time:(i&&+i!=+l.time&&s.push(e.fromDateTimes(i,l.time)),i=null)}return e.merge(s)},t.difference=function(){for(var t=this,n=arguments.length,r=new Array(n),i=0;i<n;i++)r[i]=arguments[i];return e.xor([this].concat(r)).map((function(e){return t.intersection(e)})).filter((function(e){return e&&!e.isEmpty()}))},t.toString=function(){return this.isValid?"["+this.s.toISO()+" – "+this.e.toISO()+")":"Invalid Interval"},t.toISO=function(e){return this.isValid?this.s.toISO(e)+"/"+this.e.toISO(e):"Invalid Interval"},t.toISODate=function(){return this.isValid?this.s.toISODate()+"/"+this.e.toISODate():"Invalid Interval"},t.toISOTime=function(e){return this.isValid?this.s.toISOTime(e)+"/"+this.e.toISOTime(e):"Invalid Interval"},t.toFormat=function(e,t){var n=(void 0===t?{}:t).separator,r=void 0===n?" – ":n;return this.isValid?""+this.s.toFormat(e)+r+this.e.toFormat(e):"Invalid Interval"},t.toDuration=function(e,t){return this.isValid?this.e.diff(this.s,e,t):po.invalid(this.invalidReason)},t.mapEndpoints=function(t){return e.fromDateTimes(t(this.s),t(this.e))},pn(e,[{key:"start",get:function(){return this.isValid?this.s:null}},{key:"end",get:function(){return this.isValid?this.e:null}},{key:"isValid",get:function(){return null===this.invalidReason}},{key:"invalidReason",get:function(){return this.invalid?this.invalid.reason:null}},{key:"invalidExplanation",get:function(){return this.invalid?this.invalid.explanation:null}}]),e}(),wo=function(){function e(){}return e.hasDST=function(e){void 0===e&&(e=li.defaultZone);var t=ps.now().setZone(e).set({month:12});return!e.isUniversal&&t.offset!==t.set({month:6}).offset},e.isValidIANAZone=function(e){return Kr.isValidZone(e)},e.normalizeZone=function(e){return ni(e,li.defaultZone)},e.months=function(e,t){void 0===e&&(e="long");var n=void 0===t?{}:t,r=n.locale,i=void 0===r?null:r,o=n.numberingSystem,s=void 0===o?null:o,u=n.locObj,a=void 0===u?null:u,l=n.outputCalendar,c=void 0===l?"gregory":l;return(a||xi.create(i,s,c)).months(e)},e.monthsFormat=function(e,t){void 0===e&&(e="long");var n=void 0===t?{}:t,r=n.locale,i=void 0===r?null:r,o=n.numberingSystem,s=void 0===o?null:o,u=n.locObj,a=void 0===u?null:u,l=n.outputCalendar,c=void 0===l?"gregory":l;return(a||xi.create(i,s,c)).months(e,!0)},e.weekdays=function(e,t){void 0===e&&(e="long");var n=void 0===t?{}:t,r=n.locale,i=void 0===r?null:r,o=n.numberingSystem,s=void 0===o?null:o,u=n.locObj;return((void 0===u?null:u)||xi.create(i,s,null)).weekdays(e)},e.weekdaysFormat=function(e,t){void 0===e&&(e="long");var n=void 0===t?{}:t,r=n.locale,i=void 0===r?null:r,o=n.numberingSystem,s=void 0===o?null:o,u=n.locObj;return((void 0===u?null:u)||xi.create(i,s,null)).weekdays(e,!0)},e.meridiems=function(e){var t=(void 0===e?{}:e).locale,n=void 0===t?null:t;return xi.create(n).meridiems()},e.eras=function(e,t){void 0===e&&(e="short");var n=(void 0===t?{}:t).locale,r=void 0===n?null:n;return xi.create(r,null,"gregory").eras(e)},e.features=function(){return{relative:ur()}},e}();function ko(e,t){var n=function(e){return e.toUTC(0,{keepLocalTime:!0}).startOf("day").valueOf()},r=n(t)-n(e);return Math.floor(po.fromMillis(r).as("days"))}function bo(e,t,n,r){var i=function(e,t,n){for(var r,i,o={},s=0,u=[["years",function(e,t){return t.year-e.year}],["quarters",function(e,t){return t.quarter-e.quarter}],["months",function(e,t){return t.month-e.month+12*(t.year-e.year)}],["weeks",function(e,t){var n=ko(e,t);return(n-n%7)/7}],["days",ko]];s<u.length;s++){var a=u[s],l=a[0],c=a[1];if(n.indexOf(l)>=0){var f;r=l;var d,h=c(e,t);(i=e.plus(((f={})[l]=h,f)))>t?(e=e.plus(((d={})[l]=h-1,d)),h-=1):e=i,o[l]=h}}return[e,o,i,r]}(e,t,n),o=i[0],s=i[1],u=i[2],a=i[3],l=t-o,c=n.filter((function(e){return["hours","minutes","seconds","milliseconds"].indexOf(e)>=0}));if(0===c.length){var f;if(u<t)u=o.plus(((f={})[a]=1,f));u!==o&&(s[a]=(s[a]||0)+l/(u-o))}var d,h=po.fromObject(s,r);return c.length>0?(d=po.fromMillis(l,r)).shiftTo.apply(d,c).plus(h):h}var xo={arab:"[٠-٩]",arabext:"[۰-۹]",bali:"[᭐-᭙]",beng:"[০-৯]",deva:"[०-९]",fullwide:"[０-９]",gujr:"[૦-૯]",hanidec:"[〇|一|二|三|四|五|六|七|八|九]",khmr:"[០-៩]",knda:"[೦-೯]",laoo:"[໐-໙]",limb:"[᥆-᥏]",mlym:"[൦-൯]",mong:"[᠐-᠙]",mymr:"[၀-၉]",orya:"[୦-୯]",tamldec:"[௦-௯]",telu:"[౦-౯]",thai:"[๐-๙]",tibt:"[༠-༩]",latn:"\\d"},So={arab:[1632,1641],arabext:[1776,1785],bali:[6992,7001],beng:[2534,2543],deva:[2406,2415],fullwide:[65296,65303],gujr:[2790,2799],khmr:[6112,6121],knda:[3302,3311],laoo:[3792,3801],limb:[6470,6479],mlym:[3430,3439],mong:[6160,6169],mymr:[4160,4169],orya:[2918,2927],tamldec:[3046,3055],telu:[3174,3183],thai:[3664,3673],tibt:[3872,3881]},To=xo.hanidec.replace(/[\[|\]]/g,"").split("");function Mo(e,t){var n=e.numberingSystem;return void 0===t&&(t=""),new RegExp(""+xo[n||"latn"]+t)}function Oo(e,t){return void 0===t&&(t=function(e){return e}),{regex:e,deser:function(e){var n=e[0];return t(function(e){var t=parseInt(e,10);if(isNaN(t)){t="";for(var n=0;n<e.length;n++){var r=e.charCodeAt(n);if(-1!==e[n].search(xo.hanidec))t+=To.indexOf(e[n]);else for(var i in So){var o=So[i],s=o[0],u=o[1];r>=s&&r<=u&&(t+=r-s)}}return parseInt(t,10)}return t}(n))}}}var Do="[ "+String.fromCharCode(160)+"]",No=new RegExp(Do,"g");function Eo(e){return e.replace(/\./g,"\\.?").replace(No,Do)}function _o(e){return e.replace(/\./g,"").replace(No," ").toLowerCase()}function Io(e,t){return null===e?null:{regex:RegExp(e.map(Eo).join("|")),deser:function(n){var r=n[0];return e.findIndex((function(e){return _o(r)===_o(e)}))+t}}}function Vo(e,t){return{regex:e,deser:function(e){return Sr(e[1],e[2])},groups:t}}function Co(e){return{regex:e,deser:function(e){return e[0]}}}var Fo={year:{"2-digit":"yy",numeric:"yyyyy"},month:{numeric:"M","2-digit":"MM",short:"MMM",long:"MMMM"},day:{numeric:"d","2-digit":"dd"},weekday:{short:"EEE",long:"EEEE"},dayperiod:"a",dayPeriod:"a",hour:{numeric:"h","2-digit":"hh"},minute:{numeric:"m","2-digit":"mm"},second:{numeric:"s","2-digit":"ss"}};var zo=null;function Ao(e,t){if(e.literal)return e;var n=Ur.macroTokenToFormatOpts(e.val);if(!n)return e;var r=Ur.create(t,n).formatDateTimeParts((zo||(zo=ps.fromMillis(1555555555555)),zo)).map((function(e){return function(e,t,n){var r=e.type,i=e.value;if("literal"===r)return{literal:!0,val:i};var o=n[r],s=Fo[r];return"object"==typeof s&&(s=s[o]),s?{literal:!1,val:s}:void 0}(e,0,n)}));return r.includes(void 0)?e:r}function Lo(e,t,n){var r=function(e,t){var n;return(n=Array.prototype).concat.apply(n,e.map((function(e){return Ao(e,t)})))}(Ur.parseFormat(n),e),i=r.map((function(t){return n=t,i=Mo(r=e),o=Mo(r,"{2}"),s=Mo(r,"{3}"),u=Mo(r,"{4}"),a=Mo(r,"{6}"),l=Mo(r,"{1,2}"),c=Mo(r,"{1,3}"),f=Mo(r,"{1,6}"),d=Mo(r,"{1,9}"),h=Mo(r,"{2,4}"),m=Mo(r,"{4,6}"),y=function(e){return{regex:RegExp((t=e.val,t.replace(/[\-\[\]{}()*+?.,\\\^$|#\s]/g,"\\$&"))),deser:function(e){return e[0]},literal:!0};var t},v=function(e){if(n.literal)return y(e);switch(e.val){case"G":return Io(r.eras("short",!1),0);case"GG":return Io(r.eras("long",!1),0);case"y":return Oo(f);case"yy":case"kk":return Oo(h,br);case"yyyy":case"kkkk":return Oo(u);case"yyyyy":return Oo(m);case"yyyyyy":return Oo(a);case"M":case"L":case"d":case"H":case"h":case"m":case"q":case"s":case"W":return Oo(l);case"MM":case"LL":case"dd":case"HH":case"hh":case"mm":case"qq":case"ss":case"WW":return Oo(o);case"MMM":return Io(r.months("short",!0,!1),1);case"MMMM":return Io(r.months("long",!0,!1),1);case"LLL":return Io(r.months("short",!1,!1),1);case"LLLL":return Io(r.months("long",!1,!1),1);case"o":case"S":return Oo(c);case"ooo":case"SSS":return Oo(s);case"u":return Co(d);case"uu":return Co(l);case"uuu":case"E":case"c":return Oo(i);case"a":return Io(r.meridiems(),0);case"EEE":return Io(r.weekdays("short",!1,!1),1);case"EEEE":return Io(r.weekdays("long",!1,!1),1);case"ccc":return Io(r.weekdays("short",!0,!1),1);case"cccc":return Io(r.weekdays("long",!0,!1),1);case"Z":case"ZZ":return Vo(new 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e=JSON.parse(this.responseText).intradayPricing,t=0,n=yn.DateTime.now();e.length>0&&(t=parseFloat(e[e.length-1].price).toFixed(2),n=yn.DateTime.fromISO(e[e.length-1].time));document.getElementById("md-current-price").innerHTML="$"+t;document.getElementById("md-current-time").innerHTML=n.toLocaleString(yn.DateTime.DATETIME_FULL);const r=[],i=[];e.forEach((e=>{const{price:t,time:n}=e,o=yn.DateTime.fromISO(n),s=parseFloat(t).toFixed(2);r.push(o.toUnixInteger()),i.push(s)}));const o=document.getElementById("md-intraday-chart"),s=new mn({width:300,height:120,class:"spark",pxAlign:!1,cursor:{show:!1},select:{show:!1},legend:{show:!1},scales:{x:{time:!1}},axes:[{show:!1},{show:!1}],series:[{},{stroke:"#ec5b2e",fill:"#ffb39c"}]},[r,i]).ctx.canvas;o.parentNode.append(s)}},ws.open("GET","https://medtech100.com/md100/json/pricing",!0),ws.send(); //# sourceMappingURL=index.80f28a61.js.map </script> </head> <body> <div id="md-tech-ad"> <table class="md-table" align="center" cellpadding="0" cellspacing="0" width="100%"> <tr> <td width="100%"> <div class="md-align"> <img id="md-logo" class="md-margin" src="https://images.designworldonline.com/newsletters/images/ee034d8d8274c1ee5e8111f11cf1be49.png" alt="Medtech 100 logo"> </div> </td> </tr> <tr> <td width="100%"> <div class="md-align"> <div class="margin-text"> <span style="font-weight:600;color:#e06636!important;font-size:16px!important;line-height:14px!important"> Market Summary > Current Price </span> </div> </div> </td> </tr> <tr> <td width="100%"> <div class="md-align" id="md-content-container"> <div id="md-current-price"></div> <div id="md-current-time"></div> <div id="md-chart-container"> <div id="md-intraday-chart"></div> </div> </div> </td> </tr> <tr> <td width="100%"> <div class="md-align"> <div class="md-margin-text"> <span style="font-size:13px;line-height:15px!important"> The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing. </span> </div> </div> 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