Insulin Secretory Actions of Spirulina platensis in Perfused Rat Pancreas, Isolated Mouse Islets, and Clonal Pancreatic 螔-Cells

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Spirulina platensis in Perfused Rat Pancreas, Isolated Mouse Islets, and Clonal Pancreatic 螔-Cells</title> <meta name="description" content="Insulin Secretory Actions of Spirulina platensis in Perfused Rat Pancreas, Isolated Mouse Islets, and Clonal Pancreatic 螔-Cells"> <meta name="keywords" content="Insulin, glucose, S. platensis, type 2 diabetes, medicinal plants"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a 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87351</div> </div> </div> </div> <div class="card publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">Insulin Secretory Actions of Spirulina platensis in Perfused Rat Pancreas, Isolated Mouse Islets, and Clonal Pancreatic 螔-Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jma%20Hannan">Jma Hannan</a>, <a href="https://publications.waset.org/abstracts/search?q=Prawej%20Ansari"> Prawej Ansari</a>, <a href="https://publications.waset.org/abstracts/search?q=Yasser%20H.%20A.%20Abdel-Wahab"> Yasser H. A. Abdel-Wahab</a>, <a href="https://publications.waset.org/abstracts/search?q=Peter%20R.%20Flatt"> Peter R. Flatt</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Spirulina platensis (SP, Blue-green algae) have been accepted as a supplement for the treatment of pre and post-diabetes. The present study investigated the effects of butanol fraction from ethanol extract of S. platensis on insulin release from BRIN BD11 cells, isolated mouse islets, and perfused rat pancreas, as well as glucose homeostasis in type 2 diabetic rats and their molecular pathways. In a dose-dependent manner, S. platensis increased insulin release from mouse islets and pancreatic 尾-cells. The extract also elevated insulin release in perfused rat pancreas. Glucose, isobutylmethylxanthine, tolbutamide, and a depolarizing concentration of KCl significantly potentiated insulin release from BRIN BD11 cells. The effect of diazoxide and verapamil, as well as the absence of extracellular Ca2+ showed a reduction in insulin secretion. When administered orally together with glucose (2.5g/kg bw), S. platensis extract improved fasting and postprandial blood glucose in type 2 diabetes. These data suggest that the anti-diabetic activity of S. platensis is partly mediated by insulin secretion via the KATP channel-dependent pathway/the intracellular cAMP pathway. <iframe src="https://publications.waset.org/abstracts/154092.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Insulin" title="Insulin">Insulin</a>, <a href="https://publications.waset.org/abstracts/search?q=glucose" title=" glucose"> glucose</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20platensis" title=" S. platensis"> S. platensis</a>, <a href="https://publications.waset.org/abstracts/search?q=type%202%20diabetes" title=" type 2 diabetes"> type 2 diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=medicinal%20plants" title=" medicinal plants"> medicinal plants</a> </p> <a href="https://publications.waset.org/abstracts/154092/insulin-secretory-actions-of-spirulina-platensis-in-perfused-rat-pancreas-isolated-mouse-islets-and-clonal-pancreatic-b-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/154092.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">112</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th 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Insulin Secretory Actions of Spirulina platensis in Perfused Rat Pancreas, Isolated Mouse Islets, and Clonal Pancreatic 螔-Cells