Introduction to Statistical Power - Services

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} } @media (max-width: 575px) { #hs_cos_wrapper_widget_1648498577342 .c1 .hhs-rich-text h1, #hs_cos_wrapper_widget_1648498577342 .c1 .hhs-rich-text h2,#hs_cos_wrapper_widget_1648498577342 .c1 .hhs-rich-text h3, #hs_cos_wrapper_widget_1648498577342 .c1 .hhs-rich-text h4, #hs_cos_wrapper_widget_1648498577342 .c1 .hhs-rich-text h5, #hs_cos_wrapper_widget_1648498577342 .c1 .hhs-rich-text h6, #hs_cos_wrapper_widget_1648498577342 .c1 .hhs-rich-text p, #hs_cos_wrapper_widget_1648498577342 .c1 .hhs-rich-text span, #hs_cos_wrapper_widget_1648498577342 .c1 .hhs-rich-text li { text-align: left; } } /* BACKGROUND *//* SPACING *//* PULL UP CONTENT OPTION *//* FORM STYLE *//* DIVIDER *//* VERTICAL ALIGN *//* MODAL *//******************************* END *******************************/ /******************************* COLUMN 2 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 3 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 4 *******************************/ /******************************* END *******************************/ </style> <link class="hs-async-css" rel="preload" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/template_assets/63711874859/1726675697348/VERISTAT-CLEAN-2022/css/modules/row-multi-column-content.min.css" as="style" onload="this.onload=null;this.rel='stylesheet'"> <noscript><link rel="stylesheet" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/template_assets/63711874859/1726675697348/VERISTAT-CLEAN-2022/css/modules/row-multi-column-content.min.css"></noscript> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_widget_1647442693797 .hhs-text-mod { padding-top: 50px; padding-bottom: 10px;background-color: rgba(255, 255, 255, 1);} @media (max-width: 768px) { #hs_cos_wrapper_widget_1647442693797 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px; } } @media (max-width: 575px) { #hs_cos_wrapper_widget_1647442693797 .hhs-text-mod { padding-top: 25px; padding-bottom: 25px; } } /* VIDEO BACKGROUND *//* PARALLAX */ /* HERO OVERLAY COLOR *//* OUTER/INNER SHADOW *//* PULL UP ROW *//* WAVE *//******************************* END *******************************/ /******************************* COLUMN 1 *******************************/ /* TEXT STYLES */ #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text h1, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text h2,#hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text h3, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text h4, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text h5, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text h6, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text p, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text span, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text li, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text blockquote {text-align: left; }@media (max-width: 992px) { #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text h1, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text h2,#hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text h3, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text h4, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text h5, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text h6, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text p, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text span, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text li { text-align: left; } } @media (max-width: 575px) { #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text h1, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text h2,#hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text h3, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text h4, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text h5, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text h6, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text p, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text span, #hs_cos_wrapper_widget_1647442693797 .c1 .hhs-rich-text li { text-align: left; } } /* BACKGROUND *//* SPACING *//* PULL UP CONTENT OPTION *//* FORM STYLE *//* DIVIDER *//* VERTICAL ALIGN *//* MODAL *//******************************* END *******************************/ /******************************* COLUMN 2 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 3 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 4 *******************************/ /******************************* END *******************************/ </style> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_module_16873645499843 .hhs-text-mod { padding-top: 50px; padding-bottom: 10px;background-color: rgba(255, 255, 255, 1);} @media (max-width: 768px) { #hs_cos_wrapper_module_16873645499843 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px; } } @media (max-width: 575px) { #hs_cos_wrapper_module_16873645499843 .hhs-text-mod { padding-top: 25px; padding-bottom: 25px; } } /* VIDEO BACKGROUND *//* PARALLAX */ /* HERO OVERLAY COLOR *//* OUTER/INNER SHADOW *//* PULL UP ROW *//* WAVE *//******************************* END *******************************/ /******************************* COLUMN 1 *******************************/ /* TEXT STYLES */ #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text li, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text blockquote {text-align: left; }@media (max-width: 992px) { #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text li { text-align: left; } } @media (max-width: 575px) { #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873645499843 .c1 .hhs-rich-text li { text-align: left; } } /* BACKGROUND *//* SPACING *//* PULL UP CONTENT OPTION *//* FORM STYLE *//* DIVIDER *//* VERTICAL ALIGN *//* MODAL *//******************************* END *******************************/ /******************************* COLUMN 2 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 3 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 4 *******************************/ /******************************* END *******************************/ </style> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_module_1687364604220 .hhs-text-mod { padding-top: 50px; padding-bottom: 10px;background-color: rgba(255, 255, 255, 1);} @media (max-width: 768px) { #hs_cos_wrapper_module_1687364604220 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px; } } @media (max-width: 575px) { #hs_cos_wrapper_module_1687364604220 .hhs-text-mod { padding-top: 25px; padding-bottom: 25px; } } /* VIDEO BACKGROUND *//* PARALLAX */ /* HERO OVERLAY COLOR *//* OUTER/INNER SHADOW *//* PULL UP ROW *//* WAVE *//******************************* END *******************************/ /******************************* COLUMN 1 *******************************/ /* TEXT STYLES */ #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text li, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text blockquote {text-align: left; }@media (max-width: 992px) { #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text li { text-align: left; } } @media (max-width: 575px) { #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_1687364604220 .c1 .hhs-rich-text li { text-align: left; } } /* BACKGROUND *//* SPACING *//* PULL UP CONTENT OPTION *//* FORM STYLE *//* DIVIDER *//* VERTICAL ALIGN *//* MODAL *//******************************* END *******************************/ /******************************* COLUMN 2 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 3 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 4 *******************************/ /******************************* END *******************************/ </style> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_module_16873647101182 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px;background-color: rgba(#null, 0.0);} @media (max-width: 768px) { #hs_cos_wrapper_module_16873647101182 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px; } } @media (max-width: 575px) { #hs_cos_wrapper_module_16873647101182 .hhs-text-mod { padding-top: 25px; padding-bottom: 25px; } } /* VIDEO BACKGROUND *//* PARALLAX */ /* HERO OVERLAY COLOR *//* OUTER/INNER SHADOW *//* PULL UP ROW *//* WAVE *//******************************* END *******************************/ /******************************* COLUMN 1 *******************************/ /* TEXT STYLES */ #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text li, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text blockquote {text-align: left; }@media (max-width: 992px) { #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text li { text-align: left; } } @media (max-width: 575px) { #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873647101182 .c1 .hhs-rich-text li { text-align: left; } } /* BACKGROUND *//* SPACING *//* PULL UP CONTENT OPTION *//* FORM STYLE *//* DIVIDER *//* VERTICAL ALIGN *//* MODAL *//******************************* END *******************************/ /******************************* COLUMN 2 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 3 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 4 *******************************/ /******************************* END *******************************/ </style> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_module_16873655073532 .hhs-text-mod { padding-top: 50px; padding-bottom: 10px;background-color: rgba(255, 255, 255, 1);} @media (max-width: 768px) { #hs_cos_wrapper_module_16873655073532 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px; } } @media (max-width: 575px) { #hs_cos_wrapper_module_16873655073532 .hhs-text-mod { padding-top: 25px; padding-bottom: 25px; } } /* VIDEO BACKGROUND *//* PARALLAX */ /* HERO OVERLAY COLOR *//* OUTER/INNER SHADOW *//* PULL UP ROW *//* WAVE *//******************************* END *******************************/ /******************************* COLUMN 1 *******************************/ /* TEXT STYLES */ #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text li, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text blockquote {text-align: left; }@media (max-width: 992px) { #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text li { text-align: left; } } @media (max-width: 575px) { #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873655073532 .c1 .hhs-rich-text li { text-align: left; } } /* BACKGROUND *//* SPACING *//* PULL UP CONTENT OPTION *//* FORM STYLE *//* DIVIDER *//* VERTICAL ALIGN *//* MODAL *//******************************* END *******************************/ /******************************* COLUMN 2 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 3 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 4 *******************************/ /******************************* END *******************************/ </style> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_module_16873659918233 .hhs-text-mod { padding-top: 50px; padding-bottom: 0px;background-color: rgba(255, 255, 255, 1);} @media (max-width: 768px) { #hs_cos_wrapper_module_16873659918233 .hhs-text-mod { padding-top: 50px; padding-bottom: 0px; } } @media (max-width: 575px) { #hs_cos_wrapper_module_16873659918233 .hhs-text-mod { padding-top: 25px; padding-bottom: 25px; } } /* VIDEO BACKGROUND *//* PARALLAX */ /* HERO OVERLAY COLOR *//* OUTER/INNER SHADOW *//* PULL UP ROW *//* WAVE *//******************************* END *******************************/ /******************************* COLUMN 1 *******************************/ /* TEXT STYLES */ #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text li, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text blockquote {text-align: left; }@media (max-width: 992px) { #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text li { text-align: left; } } @media (max-width: 575px) { #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873659918233 .c1 .hhs-rich-text li { text-align: left; } } /* BACKGROUND *//* SPACING *//* PULL UP CONTENT OPTION *//* FORM STYLE *//* DIVIDER *//* VERTICAL ALIGN *//* MODAL *//******************************* END *******************************/ /******************************* COLUMN 2 *******************************/ /* TEXT STYLES */ #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text,#hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text h1, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text h2,#hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text h3, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text h4, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text h5, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text h6, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text p, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text span, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text li, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text blockquote {text-align: left; }@media (max-width: 992px) { #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text h1, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text h2,#hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text h3, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text h4, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text h5, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text h6, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text p, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text span, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text li { text-align: left; } } @media (max-width: 575px) { #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text h1, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text h2,#hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text h3, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text h4, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text h5, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text h6, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text p, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text span, #hs_cos_wrapper_module_16873659918233 .c2 .hhs-rich-text li { text-align: left; } } /* BACKGROUND *//* SPACING *//* PULL UP CONTENT OPTION *//* FORM STYLE *//* DIVIDER *//* VERTICAL ALIGN *//* MODAL */ /******************************* END *******************************/ /******************************* COLUMN 3 *******************************/ /* TEXT STYLE */ #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text , #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text h1, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text h2,#hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text h3, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text h4, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text h5, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text h6, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text p, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text span, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text li, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text blockquote {text-align: left; }@media (max-width: 992px) { #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text h1, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text h2,#hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text h3, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text h4, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text h5, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text h6, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text p, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text span, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text li { text-align: left; } } @media (max-width: 575px) { #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text h1, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text h2,#hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text h3, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text h4, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text h5, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text h6, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text p, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text span, #hs_cos_wrapper_module_16873659918233 .c3 .hhs-rich-text li { text-align: left; } } /* BACKGROUND *//* SPACING *//* PULL UP CONTENT OPTION *//* FORM STYLE *//* DIVIDER *//* VERTICAL ALIGN *//* MODAL */ /******************************* END *******************************/ /******************************* COLUMN 4 *******************************/ /******************************* END *******************************/ </style> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_module_16873657955963 .hhs-text-mod { padding-top: 0px; padding-bottom: 10px;background-color: rgba(255, 255, 255, 1);} @media (max-width: 768px) { #hs_cos_wrapper_module_16873657955963 .hhs-text-mod { padding-top: 0px; padding-bottom: 50px; } } @media (max-width: 575px) { #hs_cos_wrapper_module_16873657955963 .hhs-text-mod { padding-top: 25px; padding-bottom: 25px; } } /* VIDEO BACKGROUND *//* PARALLAX */ /* HERO OVERLAY COLOR *//* OUTER/INNER SHADOW *//* PULL UP ROW *//* WAVE *//******************************* END *******************************/ /******************************* COLUMN 1 *******************************/ /* TEXT STYLES */ #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text li, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text blockquote {text-align: left; }@media (max-width: 992px) { #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text li { text-align: left; } } @media (max-width: 575px) { #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873657955963 .c1 .hhs-rich-text li { text-align: left; } } /* BACKGROUND *//* SPACING *//* PULL UP CONTENT OPTION *//* FORM STYLE *//* DIVIDER *//* VERTICAL ALIGN *//* MODAL *//******************************* END *******************************/ /******************************* COLUMN 2 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 3 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 4 *******************************/ /******************************* END *******************************/ </style> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_module_16873661933133 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px;background-color: rgba(#null, 0.0);} @media (max-width: 768px) { #hs_cos_wrapper_module_16873661933133 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px; } } @media (max-width: 575px) { #hs_cos_wrapper_module_16873661933133 .hhs-text-mod { padding-top: 25px; padding-bottom: 25px; } } /* VIDEO BACKGROUND *//* PARALLAX */ /* HERO OVERLAY COLOR *//* OUTER/INNER SHADOW *//* PULL UP ROW *//* WAVE *//******************************* END *******************************/ /******************************* COLUMN 1 *******************************/ /* TEXT STYLES */ #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text li, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text blockquote {text-align: left; }@media (max-width: 992px) { #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text li { text-align: left; } } @media (max-width: 575px) { #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873661933133 .c1 .hhs-rich-text li { text-align: left; } } /* BACKGROUND *//* SPACING *//* PULL UP CONTENT OPTION *//* FORM STYLE *//* DIVIDER *//* VERTICAL ALIGN *//* MODAL *//******************************* END *******************************/ /******************************* COLUMN 2 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 3 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 4 *******************************/ /******************************* END *******************************/ </style> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_module_16873663845253 .hhs-text-mod { padding-top: 50px; padding-bottom: 10px;background-color: rgba(255, 255, 255, 1);} @media (max-width: 768px) { #hs_cos_wrapper_module_16873663845253 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px; } } @media (max-width: 575px) { #hs_cos_wrapper_module_16873663845253 .hhs-text-mod { padding-top: 25px; padding-bottom: 25px; } } /* VIDEO BACKGROUND *//* PARALLAX */ /* HERO OVERLAY COLOR *//* OUTER/INNER SHADOW *//* PULL UP ROW *//* WAVE *//******************************* END *******************************/ /******************************* COLUMN 1 *******************************/ /* TEXT STYLES */ #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text li, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text blockquote {text-align: left; }@media (max-width: 992px) { #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text li { text-align: left; } } @media (max-width: 575px) { #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_16873663845253 .c1 .hhs-rich-text li { text-align: left; 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Statistical Power</h2> <h1>Below is an introduction to the concept of statistical power, a term you likely have heard in the context of designing a clinical study and planning the number of participants required to address the primary objective of the study.</h1> </div> </div> </div> </div> </div> </div> <span class="hhs-row-overlay"></span> </div>      </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-3 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-4 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1647442693797" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" 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style="display:none">contact-us</span> <span style="display:none">rfp</span>  <span style="display:none"> introduction-statistical-power </span> Statistical Power  </div> </div> </div> </div> </div> <div class="container " style=""> <div class="row"> <div data-wow-delay="none" class="wow none col-sm-12 c1 "> <div class="col-inner"> <div class="hhs-rich-text-in"> <div class="hhs-rich-text"> <h3 style="text-align: left;">Figure 1</h3> <p><a href="https://info.veristat.com/hubfs/StatisticalPower_Figure1_Full.png" rel="noopener" target="_blank"><img src="https://www.veristat.com/hs-fs/hubfs/Statistical%20Power_Figure1.png?width=277&height=185&name=Statistical%20Power_Figure1.png" width="277" height="185" loading="lazy" alt="Statistical Power_Figure1" style="height: auto; max-width: 100%; width: 277px; float: left; margin: 0px 5px 0px 0px;" srcset="https://www.veristat.com/hs-fs/hubfs/Statistical%20Power_Figure1.png?width=139&height=93&name=Statistical%20Power_Figure1.png 139w, https://www.veristat.com/hs-fs/hubfs/Statistical%20Power_Figure1.png?width=277&height=185&name=Statistical%20Power_Figure1.png 277w, https://www.veristat.com/hs-fs/hubfs/Statistical%20Power_Figure1.png?width=416&height=278&name=Statistical%20Power_Figure1.png 416w, https://www.veristat.com/hs-fs/hubfs/Statistical%20Power_Figure1.png?width=554&height=370&name=Statistical%20Power_Figure1.png 554w, https://www.veristat.com/hs-fs/hubfs/Statistical%20Power_Figure1.png?width=693&height=463&name=Statistical%20Power_Figure1.png 693w, https://www.veristat.com/hs-fs/hubfs/Statistical%20Power_Figure1.png?width=831&height=555&name=Statistical%20Power_Figure1.png 831w" sizes="(max-width: 277px) 100vw, 277px"></a></p> <p style="text-align: left;"><span><strong>Figure 1</strong> </span>presents the standard normal distribution with a mean of zero and a standard deviation of 1. The probability density for a continuous variable is the probability per unit length.<span>  </span>The probability density at a single point will equal 0. The cumulative probability density over a range of values will be greater than 0 and computed as the integral of the probability density function over the designated interval, equaling the area under the curve.</p> <p>For example, in <span><strong>Figure 1</strong></span>, if we look at the probability that z equals -1, the probability will equal 0. We can instead look at the probability of z falling between -1 and 1. This value is non-zero and is equal to the area under the normal curve falling below and within the orange boundaries. The area is approximately 0.6826.</p> </div> </div> </div> </div> </div> </div> <span class="hhs-row-overlay"></span> </div>      </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-5 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-6 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_16873645499843" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module">  <div id="" class="hhs-text-mod show-mobile show-tablet show-desktop " style=";">  <div class="gg-breadcrumb-wr">   <div class="gg-breadcrumb"> <div class="container"> <div class="row"> <div 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style="display:none"> introduction-statistical-power </span> Statistical Power  </div> </div> </div> </div> </div> <div class="container " style=""> <div class="row"> <div data-wow-delay="none" class="wow none col-sm-12 c1 "> <div class="col-inner"> <div class="hhs-rich-text-in"> <div class="hhs-rich-text"> <h3 style="text-align: left;">Figure 2</h3> <p><a href="https://info.veristat.com/hubfs/StatisticalPower_Figure2_Full.png" rel="noopener" target="_blank"><img src="https://www.veristat.com/hs-fs/hubfs/Veristat_StatisticalPower_Fig2.webp?width=318&height=209&name=Veristat_StatisticalPower_Fig2.webp" alt="Veristat_StatisticalPower_Fig2" width="318" height="209" loading="lazy" style="height: auto; max-width: 100%; width: 318px; float: left; margin: 0px 5px 0px 0px;" srcset="https://www.veristat.com/hs-fs/hubfs/Veristat_StatisticalPower_Fig2.webp?width=159&height=105&name=Veristat_StatisticalPower_Fig2.webp 159w, https://www.veristat.com/hs-fs/hubfs/Veristat_StatisticalPower_Fig2.webp?width=318&height=209&name=Veristat_StatisticalPower_Fig2.webp 318w, https://www.veristat.com/hs-fs/hubfs/Veristat_StatisticalPower_Fig2.webp?width=477&height=314&name=Veristat_StatisticalPower_Fig2.webp 477w, https://www.veristat.com/hs-fs/hubfs/Veristat_StatisticalPower_Fig2.webp?width=636&height=418&name=Veristat_StatisticalPower_Fig2.webp 636w, https://www.veristat.com/hs-fs/hubfs/Veristat_StatisticalPower_Fig2.webp?width=795&height=523&name=Veristat_StatisticalPower_Fig2.webp 795w, https://www.veristat.com/hs-fs/hubfs/Veristat_StatisticalPower_Fig2.webp?width=954&height=627&name=Veristat_StatisticalPower_Fig2.webp 954w" sizes="(max-width: 318px) 100vw, 318px"></a></p> <p style="text-align: left;">The standard normal distribution is convenient because the mean equals 0, the standard deviation equals 1, and many calculations therefore become straightforward. The same concepts can be extended to location shifts and scaling of the normal distribution. <span><strong>Figure 2</strong></span> illustrates four normal distributions with varying location (i.e., mean values) and scale (i.e., standard deviations)</p> </div> </div> </div> </div> </div> </div> <span class="hhs-row-overlay"></span> </div>      </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-7 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-8 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_1687364604220" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" 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style="display:none">contact-us</span> <span style="display:none">rfp</span>  <span style="display:none"> introduction-statistical-power </span> Statistical Power  </div> </div> </div> </div> </div> <div class="container " style=""> <div class="row"> <div data-wow-delay="none" class="wow none col-sm-12 c1 "> <div class="col-inner"> <div class="hhs-rich-text-in"> <div class="hhs-rich-text"> <h3 style="text-align: left;">Figure 3</h3> <p><a href="https://info.veristat.com/hubfs/StatisticalPower_Figure3_Full.png" rel="noopener" target="_blank"><img src="https://www.veristat.com/hs-fs/hubfs/Statistical%20Power_Figure3.png?width=282&height=188&name=Statistical%20Power_Figure3.png" width="282" height="188" loading="lazy" alt="Statistical Power_Figure3" style="height: auto; max-width: 100%; width: 282px; float: left;" srcset="https://www.veristat.com/hs-fs/hubfs/Statistical%20Power_Figure3.png?width=141&height=94&name=Statistical%20Power_Figure3.png 141w, https://www.veristat.com/hs-fs/hubfs/Statistical%20Power_Figure3.png?width=282&height=188&name=Statistical%20Power_Figure3.png 282w, https://www.veristat.com/hs-fs/hubfs/Statistical%20Power_Figure3.png?width=423&height=282&name=Statistical%20Power_Figure3.png 423w, https://www.veristat.com/hs-fs/hubfs/Statistical%20Power_Figure3.png?width=564&height=376&name=Statistical%20Power_Figure3.png 564w, https://www.veristat.com/hs-fs/hubfs/Statistical%20Power_Figure3.png?width=705&height=470&name=Statistical%20Power_Figure3.png 705w, https://www.veristat.com/hs-fs/hubfs/Statistical%20Power_Figure3.png?width=846&height=564&name=Statistical%20Power_Figure3.png 846w" sizes="(max-width: 282px) 100vw, 282px"></a></p> <p style="text-align: left;">For simplicity, <strong>Figure 3</strong> illustrates two identical normal distributions with a location shift so that the means are different (µ<span><sub>0</sub></span> and µ<span><sub>1</sub></span>). The standard deviations are equivalent.</p> <p>Consider a one-sided null hypothesis: H<span><sub>0</sub></span>: µ<span><sub>0</sub></span> ≥ µ<span><sub>1</sub></span> compared to the alternative hypothesis: H<span><sub>A</sub></span>: µ<span><sub>0</sub></span> < µ<span><sub>1</sub></span>.<span>  </span>The <strong>Type 1 error rate</strong>, α, is the probability of falsely rejecting the null hypothesis under the condition that the null hypothesis is true. Using the normal distributions in <span><strong>Figure 3</strong></span>, we can identify the critical value z* for a one-sided hypothesis test, corresponding to the upper 100*α% of the null distribution where the null hypothesis is rejected. When performing a statistical hypothesis test, we would interpret any value falling above z* would be unlikely to come from the null distribution. If the null hypothesis is true, this would be a “false positive.”</p> <p>The <strong>Power</strong> of the study is the cumulative density of the alternative hypothesis probability function, centered µ<span><sub>1</sub></span>, that falls above the critical value z*. Values above z* allow us to reject the null hypothesis. If the null hypothesis is false and the alternative hypothesis is true, we want to have a high probability of rejecting the null hypothesis. Therefore, when designing a study, we would typically plan for a high power, often 80% or 90%.</p> <p>The <strong>Type 2 error rate </strong>is equal to 1-power. It is the probability of falsely failing to reject the null hypothesis under the condition that the alternative hypothesis is true. In <span><strong>Figure 3</strong></span>, the type 2 error rate, or β, is the cumulative probability density of the alternative distribution that falls below z*.</p> </div> </div> </div> </div> </div> </div> <span class="hhs-row-overlay"></span> </div>      </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-9 dnd-section dnd_area-row-4-background-layers dnd_area-row-4-background-gradient"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-10 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_16873647101182" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" 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style="display:none">contact-us</span> <span style="display:none">rfp</span>  <span style="display:none"> introduction-statistical-power </span> Statistical Power  </div> </div> </div> </div> </div> <div class="container " style=""> <div class="row"> <div data-wow-delay="none" class="wow none col-sm-12 c1 "> <div class="col-inner"> <div class="hhs-rich-text-in"> <div class="hhs-rich-text"> <h4>Introduction to Sample Size, Standard Deviation, and Power</h4> <p>When planning a study, researchers must determine the number of participants required for analysis of the primary endpoint to address the primary objective of the study, but what is an appropriate sample size?</p> </div> </div> </div> </div> </div> </div> <span class="hhs-row-overlay"></span> </div>      </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-11 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" 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style="display:none">pharmacovigilance</span> <span style="display:none">services/strategic-resourcing</span> <span style="display:none"></span> <span style="display:none">library</span> <span style="display:none">blog</span> <span style="display:none"></span> <span style="display:none"></span> <span style="display:none"></span> <span style="display:none">latest-newsletter</span> <span style="display:none">contact-us</span> <span style="display:none">rfp</span>  <span style="display:none"> introduction-statistical-power </span> Statistical Power  </div> </div> </div> </div> </div> <div class="container " style=""> <div class="row"> <div data-wow-delay="none" class="wow none col-sm-12 c1 "> <div class="col-inner"> <div class="hhs-rich-text-in"> <div class="hhs-rich-text"> <h3 style="text-align: left;">Figure 4</h3> <p><a href="https://info.veristat.com/hubfs/StatisticalPower_Figure4_Full.png" rel="noopener" target="_blank"><img src="https://www.veristat.com/hs-fs/hubfs/Veristat_StatisticalPower_Fig4.webp?width=318&height=193&name=Veristat_StatisticalPower_Fig4.webp" alt="Veristat_StatisticalPower_Fig4" width="318" height="193" loading="lazy" style="height: auto; max-width: 100%; width: 318px; float: left;" srcset="https://www.veristat.com/hs-fs/hubfs/Veristat_StatisticalPower_Fig4.webp?width=159&height=97&name=Veristat_StatisticalPower_Fig4.webp 159w, https://www.veristat.com/hs-fs/hubfs/Veristat_StatisticalPower_Fig4.webp?width=318&height=193&name=Veristat_StatisticalPower_Fig4.webp 318w, https://www.veristat.com/hs-fs/hubfs/Veristat_StatisticalPower_Fig4.webp?width=477&height=290&name=Veristat_StatisticalPower_Fig4.webp 477w, https://www.veristat.com/hs-fs/hubfs/Veristat_StatisticalPower_Fig4.webp?width=636&height=386&name=Veristat_StatisticalPower_Fig4.webp 636w, https://www.veristat.com/hs-fs/hubfs/Veristat_StatisticalPower_Fig4.webp?width=795&height=483&name=Veristat_StatisticalPower_Fig4.webp 795w, https://www.veristat.com/hs-fs/hubfs/Veristat_StatisticalPower_Fig4.webp?width=954&height=579&name=Veristat_StatisticalPower_Fig4.webp 954w" sizes="(max-width: 318px) 100vw, 318px"></a></p> <p style="text-align: left;">Consider two normal distributions with means µ<span><sub>0</sub></span> and µ<span><sub>1</sub></span> and standard deviations equal to 1. (<span><strong>Figure 4</strong></span>)<span>  </span>We can test a one-sided null hypothesis: H<span><sub>0</sub></span>: µ<span><sub>0</sub></span> ≥ µ<span><sub>1</sub></span> compared to the alternative hypothesis: H<span><sub>A</sub></span>: µ<span><sub>0</sub></span> < µ<span><sub>1</sub></span>.<span>  </span>The <strong>type I error rate (α)</strong> is the probability of rejecting the null hypothesis under the condition that the null hypothesis is true.<span>  </span>The <strong>power (1-β)</strong> is the probability of correctly rejecting a false null hypothesis.<span>  </span>This document focuses on the normal distribution, though the same concepts can be directly transferred to any other distribution or applied statistic.</p> <p>An appropriate sample size is selected to ensure a high probability of failing to reject the null hypothesis if it is true, and to reject the null hypothesis if it is false.<span>  </span>The sample size can be computed as a function of the type I error rate, power, and standard deviation of the sample.<span>  </span>The type I error rate and power can be selected <i>a priori</i> and are fixed values for the design of the study.<span>  </span>The hypothesized means and differences in means are assumptions made for the design of the study.<span>  </span>The sample size will be selected to provide sufficient precision of the estimated means in order to achieve the targeted power and type I error rate under the assumptions made during study planning.</p> </div> </div> </div> </div> </div> </div> <span class="hhs-row-overlay"></span> </div>      </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-13 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-14 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span 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style="display:none">services/strategic-resourcing</span> <span style="display:none"></span> <span style="display:none">library</span> <span style="display:none">blog</span> <span style="display:none"></span> <span style="display:none"></span> <span style="display:none"></span> <span style="display:none">latest-newsletter</span> <span style="display:none">contact-us</span> <span style="display:none">rfp</span>  <span style="display:none"> introduction-statistical-power </span> Statistical Power  </div> </div> </div> </div> </div> <div class="container " style=""> <div class="row"> <div data-wow-delay="none" class="wow none col-lg-4 col-md-12 c1 "> <div class="col-inner"> <div class="hhs-rich-text-in"> <div class="hhs-rich-text"> <h3 style="text-align: left;">Figure 5a</h3> <p><a href="https://info.veristat.com/hubfs/StatisticalPower_Figure5a_Full.png" rel="noopener" target="_blank"><img src="https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5a_Full.png?width=297&height=244&name=StatisticalPower_Figure5a_Full.png" width="297" height="244" loading="lazy" alt="StatisticalPower_Figure5a_Full" style="height: auto; max-width: 100%; width: 297px;" srcset="https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5a_Full.png?width=149&height=122&name=StatisticalPower_Figure5a_Full.png 149w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5a_Full.png?width=297&height=244&name=StatisticalPower_Figure5a_Full.png 297w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5a_Full.png?width=446&height=366&name=StatisticalPower_Figure5a_Full.png 446w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5a_Full.png?width=594&height=488&name=StatisticalPower_Figure5a_Full.png 594w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5a_Full.png?width=743&height=610&name=StatisticalPower_Figure5a_Full.png 743w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5a_Full.png?width=891&height=732&name=StatisticalPower_Figure5a_Full.png 891w" sizes="(max-width: 297px) 100vw, 297px"></a></p> <p> </p> </div> </div> </div> </div> <div data-wow-delay="none" class="wow none col-lg-4 col-md-12 c2 "> <div class="col-inner"> <div class="hhs-rich-text-in"> <div class="hhs-rich-text"> <h3>Figure 5b</h3> <p><a href="https://info.veristat.com/hubfs/StatisticalPower_Figure5b_Full.png" rel="noopener" target="_blank"><img src="https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5b_Full.png?width=284&height=244&name=StatisticalPower_Figure5b_Full.png" width="284" height="244" loading="lazy" alt="StatisticalPower_Figure5b_Full" style="height: auto; max-width: 100%; width: 284px;" srcset="https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5b_Full.png?width=142&height=122&name=StatisticalPower_Figure5b_Full.png 142w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5b_Full.png?width=284&height=244&name=StatisticalPower_Figure5b_Full.png 284w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5b_Full.png?width=426&height=366&name=StatisticalPower_Figure5b_Full.png 426w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5b_Full.png?width=568&height=488&name=StatisticalPower_Figure5b_Full.png 568w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5b_Full.png?width=710&height=610&name=StatisticalPower_Figure5b_Full.png 710w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5b_Full.png?width=852&height=732&name=StatisticalPower_Figure5b_Full.png 852w" sizes="(max-width: 284px) 100vw, 284px"></a></p> <p> </p> </div> </div> </div> </div> <div data-wow-delay="none" class="wow none col-lg-4 col-md-12 c3 "> <div class="col-inner"> <div class="hhs-rich-text-in"> <div class="hhs-rich-text"> <h3>Figure 5c</h3> <p><a href="https://info.veristat.com/hubfs/StatisticalPower_Figure5c_Full.png" rel="noopener" target="_blank"><img src="https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5c_Full.png?width=297&height=252&name=StatisticalPower_Figure5c_Full.png" width="297" height="252" loading="lazy" alt="StatisticalPower_Figure5c_Full" style="height: auto; max-width: 100%; width: 297px;" srcset="https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5c_Full.png?width=149&height=126&name=StatisticalPower_Figure5c_Full.png 149w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5c_Full.png?width=297&height=252&name=StatisticalPower_Figure5c_Full.png 297w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5c_Full.png?width=446&height=378&name=StatisticalPower_Figure5c_Full.png 446w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5c_Full.png?width=594&height=504&name=StatisticalPower_Figure5c_Full.png 594w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5c_Full.png?width=743&height=630&name=StatisticalPower_Figure5c_Full.png 743w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure5c_Full.png?width=891&height=756&name=StatisticalPower_Figure5c_Full.png 891w" sizes="(max-width: 297px) 100vw, 297px"></a></p> <p> </p> </div> </div> </div> </div> </div> </div> <span class="hhs-row-overlay"></span> </div>      </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-15 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-16 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_16873657955963" class="hs_cos_wrapper 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style="display:none">blog</span> <span style="display:none"></span> <span style="display:none"></span> <span style="display:none"></span> <span style="display:none">latest-newsletter</span> <span style="display:none">contact-us</span> <span style="display:none">rfp</span>  <span style="display:none"> introduction-statistical-power </span> Statistical Power  </div> </div> </div> </div> </div> <div class="container " style=""> <div class="row"> <div data-wow-delay="none" class="wow none col-sm-12 c1 "> <div class="col-inner"> <div class="hhs-rich-text-in"> <div class="hhs-rich-text"> <p>Consider <span><strong>Figure 5a</strong></span>, illustrating two normal distributions with a<span><sub>0</sub></span> and a<span><sub>1</sub></span> having a large difference compared to <span><strong>Figure 5b</strong></span> where b<span><sub>0</sub></span> and b<span><sub>1</sub></span> fall closer together.<span>  </span>The underlying standard deviation expected from each distribution is the same.<span>  </span>In <span><strong>Figure 5a</strong></span>, the standard deviation is small in comparison to the difference between a<span><sub>0</sub></span> and a<span><sub>1</sub></span>.<span>  </span>In <span><strong>Figure 5b</strong></span>, the standard deviation is large in comparison to the smaller difference between b<span><sub>0</sub></span> and b<span><sub>1</sub></span>.<span>  </span>To increase the power of a hypothesis test of the null and alternative hypothesis: H<span><sub>0</sub></span>: b<span><sub>0</sub></span> ≥ b<span><sub>1</sub></span> vs. H<span><sub>A</sub></span>: b<span><sub>0</sub></span> < b<span><sub>1</sub></span>, the precision of the sample estimate must be increased, which can be achieved by increasing the sample size, and therefore reducing the standard error of the sample, <span><strong>Figure 5c</strong></span>. </p> <p><strong>Standard error</strong> = Standard deviation/ square root of the sample size<span>.</span></p> <p>Given these relationships, an adjustment of the sample size can be used to control the relative precision of the sample estimates and therefore can influence the power of the study.</p> <p>When planning a study, the type I error rate is typically determined prior to sample size calculations and captures the risk of moving forward under a “false positive” condition.<span>  </span>While exceptions exist, for early phase clinical studies (i.e., Phase 1), a one-sided type I error rate may be more lenient, e.g., 5% or 10%, whereas a later phase clinical study (i.e., Phase 3), the one-sided type I error rate will typically be smaller, e.g., 2.5%.<span>  </span>The power of a later phase study is typically targeted to be between 80% or 90%.<span>  </span>During the study design and sample size calculation, sample sizes can be computed for a series of values for µ<span><sub>0</sub></span> or µ<span><sub>1</sub></span> and assumed standard deviations. </p> <p>The balance of sample size versus standard deviation versus mean versus power can be an extensive conversation when designing a study and should be based on prior research either in clinic or that is available in literature, as well as considering what are clinically meaningful differences to select an observable difference with a sufficient precision to allow reasonable conclusions from a newly designed study.</p> <p> </p> </div> </div> </div> </div> </div> </div> <span class="hhs-row-overlay"></span> </div>      </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-17 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell cell_16873662056232-background-gradient cell_16873662056232-background-layers dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-18 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" 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They can inform how and when researchers might observe a statistically significant difference between two values and can be used to better inform sample size selection during protocol development.</p> <p>The two values could be the difference in means or proportions between two treatment groups or could be a comparison of either a mean or a proportion to a predefined constant.<span>  </span>This document focuses on the normal distribution, though the concepts discussed can be directly transferred to any other distribution or applied statistic.</p> <p>Consider a one-sided null hypothesis: H<span><sub>0</sub></span>: µ<span><sub>0</sub></span> ≥ µ<span><sub>1</sub></span> compared to the alternative hypothesis: H<span><sub>A</sub></span>: µ<span><sub>0</sub></span> < µ<span><sub>1</sub></span>.</p> </div> </div> </div> </div> </div> </div> <span class="hhs-row-overlay"></span> </div>      </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 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style="display:none">services/biometrics/statistical-programming</span> <span style="display:none">services/biometrics/standards-implementation</span> <span style="display:none">pharmacovigilance</span> <span style="display:none">services/strategic-resourcing</span> <span style="display:none"></span> <span style="display:none">library</span> <span style="display:none">blog</span> <span style="display:none"></span> <span style="display:none"></span> <span style="display:none"></span> <span style="display:none">latest-newsletter</span> <span style="display:none">contact-us</span> <span style="display:none">rfp</span>  <span style="display:none"> introduction-statistical-power </span> Statistical Power  </div> </div> </div> </div> </div> <div class="container " style=""> <div class="row"> <div data-wow-delay="none" class="wow none col-sm-12 c1 "> <div class="col-inner"> <div class="hhs-rich-text-in"> <div class="hhs-rich-text"> <h3 style="text-align: left;">Figure 6</h3> <p><a href="https://info.veristat.com/hubfs/StatisticalPower_Figure6_Full.png" rel="noopener" target="_blank"><img src="https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure6_Full.png?width=277&height=232&name=StatisticalPower_Figure6_Full.png" width="277" height="232" loading="lazy" alt="StatisticalPower_Figure6_Full" style="height: auto; max-width: 100%; width: 277px; float: left;" srcset="https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure6_Full.png?width=139&height=116&name=StatisticalPower_Figure6_Full.png 139w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure6_Full.png?width=277&height=232&name=StatisticalPower_Figure6_Full.png 277w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure6_Full.png?width=416&height=348&name=StatisticalPower_Figure6_Full.png 416w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure6_Full.png?width=554&height=464&name=StatisticalPower_Figure6_Full.png 554w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure6_Full.png?width=693&height=580&name=StatisticalPower_Figure6_Full.png 693w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure6_Full.png?width=831&height=696&name=StatisticalPower_Figure6_Full.png 831w" sizes="(max-width: 277px) 100vw, 277px"></a></p> <p>The <strong>Type 1 error rate</strong> <strong>(α)</strong>, is the probability of falsely rejecting the null hypothesis under the condition that the null hypothesis is true. Using the normal distributions in <span><strong>Figure 6</strong></span>, we can identify the critical value z* for a one-sided hypothesis test, corresponding to the upper 100*α% of the null distribution where the null hypothesis is rejected. When performing a statistical hypothesis test, we would interpret any value falling above z* would be unlikely to come from the null distribution. If the null hypothesis is true, this would be a “false positive”.</p> <p>The <strong>Power</strong> of the study is the probability of correctly rejecting a false null hypothesis, also known as the cumulative density of the alternative hypothesis probability function, centered µ<span><sub>1</sub></span>, that falls above the critical value z*.<span>  </span>Values above z* allow us to reject the null hypothesis. If the null hypothesis is false and the alternative hypothesis is true, we want to have a high probability of rejecting the null hypothesis. Therefore, when designing a study, we would typically plan for a high power, often 80% or 90%.</p> <p>If we consider the critical value, z*, we can see that any values above z* are statistically significant. When we are designing the study, we may want to know the <strong>minimum detectable difference</strong>, the minimum magnitude of difference that needs to be observed in order to have a statistically significant result. It is important to ensure this value corresponds to a relevant difference that is clinically meaningful.<span>  </span>If, for example, the difference observed in a new drug clinical study is very small but statistically significant due to large sample size and low standard deviation, this may not be a meaningful improvement over the already available therapy and therefore is not a meaningful difference to observe. </p> <p>To determine the minimum detectable difference, we can use the critical value from the standard normal distribution (Z-score) and translate this value to the scale of the observed sample values to understand how big of a difference is required to observe a statistically significant result under the assumed null value, type I error rate, and standard deviation.</p> </div> </div> </div> </div> </div> </div> <span class="hhs-row-overlay"></span> </div>      </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-21 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style="display:none">services/biometrics/statistical-programming</span> <span style="display:none">services/biometrics/standards-implementation</span> <span style="display:none">pharmacovigilance</span> <span style="display:none">services/strategic-resourcing</span> <span style="display:none"></span> <span style="display:none">library</span> <span style="display:none">blog</span> <span style="display:none"></span> <span style="display:none"></span> <span style="display:none"></span> <span style="display:none">latest-newsletter</span> <span style="display:none">contact-us</span> <span style="display:none">rfp</span>  <span style="display:none"> introduction-statistical-power </span> Statistical Power  </div> </div> </div> </div> </div> <div class="container " style=""> <div class="row"> <div data-wow-delay="none" class="wow none col-sm-12 c1 "> <div class="col-inner"> <div class="hhs-rich-text-in"> <div class="hhs-rich-text"> <h3 style="text-align: left;">Figure 7</h3> <p><a href="https://info.veristat.com/hubfs/StatisticalPower_Figure7_Full.png" rel="noopener" target="_blank"><img src="https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure7_Full.png?width=277&height=229&name=StatisticalPower_Figure7_Full.png" width="277" height="229" loading="lazy" alt="StatisticalPower_Figure7_Full" style="height: auto; max-width: 100%; width: 277px; float: left;" srcset="https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure7_Full.png?width=139&height=115&name=StatisticalPower_Figure7_Full.png 139w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure7_Full.png?width=277&height=229&name=StatisticalPower_Figure7_Full.png 277w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure7_Full.png?width=416&height=344&name=StatisticalPower_Figure7_Full.png 416w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure7_Full.png?width=554&height=458&name=StatisticalPower_Figure7_Full.png 554w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure7_Full.png?width=693&height=573&name=StatisticalPower_Figure7_Full.png 693w, https://www.veristat.com/hs-fs/hubfs/StatisticalPower_Figure7_Full.png?width=831&height=687&name=StatisticalPower_Figure7_Full.png 831w" sizes="(max-width: 277px) 100vw, 277px"></a></p> <p>While the translation from the normal distribution to a difference in means (for example) is a straightforward calculation, sometimes test statistics are difficult to back-transform and the calculation is not obvious.<span>  </span>As an alternative approach, we can consider <span><strong>Figure 7</strong></span> with two normal distributions, one centered on µ<span><sub>0</sub></span> and one centered on z*.<span>  </span>Recall that power is equal to the probability of rejecting the null hypothesis if the alternative hypothesis is true.<span>  </span>It is computed as the cumulative probability density falling above the critical value, z*. </p> <p>The sample size was determined given a set type I error rate, power, hypothesized difference (between µ<span><sub>0</sub></span> and µ<span><sub>1</sub></span>), and standard deviation.<span>  </span>To determine the critical value, we will keep the sample size, type I error rate, and standard deviation constant but will reduce the power to 50%.<span>  </span>From sample size software we can compute the difference that would be required to provide 50% power, which is equivalent to an alternative hypothesis centered at the critical value z*.<span>  </span>This is the minimum detectable difference that can be observed with a statistically significant p-value under the assumed sample size, type I error rate, and standard deviation.</p> </div> </div> </div> </div> </div> </div> <span class="hhs-row-overlay"></span> </div>      </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-23 dnd-section dnd_area-row-11-max-width-section-centering"> <div 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