5 New Weight-Loss Drugs to Watch in Race for the Next Ozempic

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Landsverk","sameAs":"https://www.businessinsider.com/author/gabby-landsverk"},"publisher":{"@context":"http://schema.org","@type":"Organization","name":"Business Insider","legalName":"Insider Inc.","foundingDate":"2007","url":"www.businessinsider.com","sameAs":["https://www.instagram.com/businessinsider","https://www.twitter.com/businessinsider","https://www.facebook.com/businessinsider","https://www.linkedin.com/company/businessinsider","https://www.youtube.com/@BusinessInsider"],"founder":{"@type":"Person","name":"Henry Blodget"},"logo":{"@type":"ImageObject","url":"https://www.businessinsider.com/public/assets/logos/structured-data.png"}},"headline":"5 new weight-loss drugs to watch in race for the next Ozempic","alternativeHeadline":"5 new weight-loss drugs to watch in the fight for the next Ozempic","image":{"@type":"ImageObject","url":"https://i.insider.com/6737c299192f52589858f928?width=1200&format=jpeg","width":1200,"height":900,"caption":"A pill"},"name":"5 new weight-loss drugs to watch in the fight for the next Ozempic","datePublished":"2024-11-16T10:47:01Z","dateModified":"2024-11-18T18:47:00Z","description":"Biotech companies are racing to find Ozempic 2.0, hoping for a slice of a multi-billion-dollar industry. A few stand-out drugs are emerging. ","keywords":"Health, Weight Loss, semaglutide","articleBody":"In the race to find Ozempic 2.0, a few stand-outs are emerging.While GLP-1 drugs have paved the way for a new era of healthcare, they have some drawbacks. They need to be injected (a draw-back for some patients), that injection must be administered once a week for effects to last, and manufacturers struggled to keep up with demand.Competition is on the way: Dozens of experimental new weight-loss medications are in development as biotech companies race to get a slice of a market forecast to be worth $100 billion.Some are combining multiple hormones at once for enhanced effects to regulate appetite, blood sugar, and digestion. Some are trying to package these sought-after ingredients into pill form, or injectables that last longer.The next breakthrough drug may not be available until at least 2027, but the leading candidates in production give a good sense of what this market could look like in years to come.\"Anti-obesity medications are emerging at an astonishing pace,\" Dr. Christopher McGowan, a gastroenterologist and obesity medicine specialist, told Business Insider. \"Forthcoming medications take the blockbuster GLP-1 medications and up the ante.\"Why it's interesting: Retatrutide is a next-gen medication that acts on three different hormones, earning it the nickname Triple-G.That means it could lead to more weight loss than current medications like Ozempic, Wegovy, and Mounjaro, comparable to bariatric surgery.How it works: Eli Lilly's retatrutide drug is administered the same way as the market leaders Ozempic, Wegovy, Mounjaro, and Zepbound: it's a once-weekly injection.What's unique is the substance.Like semaglutide (the active ingredient in Ozempic and Wegovy), it works on GLP-1, a hormone that regulates blood sugar and appetite.Like tirzepatide (the drug in Mounjaro and Zepbound), it also works on GIP, a hormone that manages blood sugar.Uniquely, retatrutide has an additional effect, mimicking another hormone called glucagon, which may help increase the body's energy use. The idea is that it promotes weight loss by not only curbing appetite, but also burning more calories.Current research: The results of mid-stage trials found that patients taking retatrutide lost an average of 58 pounds in 11 months, more and faster weight loss than has been seen with drugs currently on the market.Timeline: Retatrutide is currently being studied in Phase III trials which are scheduled to be completed in early 2026.Why it's interesting: Early research suggests VK2735, from California-based Viking Therapeutics, could work faster than competitors like semaglutide and tirzepatide.How it works: VK2735 acts on both GLP-1 and GIP, similar to tirzepatide (the active ingredient in Mounjaro and Zepbound).It's being tested in pill form as well as a once-weekly injection.Current research: A mid-stage trial found patients on VK2735 lost an average of 14.7% of their body weight (about 32 pounds) by 13 weeks.It hasn't been directly tested against other medications but the results are comparable to what we've seen in trials of semaglutide (Ozempic, Wegovy) after 68 weeks. That suggests similar weight loss but in a fraction of the time.Timeline: Viking Therapeutics recently announced it would meet with the FDA about the end of Phase II for VK2735 injections before 2025. The oral form of VK2735 is expected to enter Phase II trials by the end of this year, too.Why it's interesting: Eli Lilly may beat Viking Therapeutics to get the first oral GLP-1 to market.Their drug orforglipron appeals to patients who can't or don't want to use injected medications. It is also expected to be cheaper, since it's easier to produce (orforglipron isn't a peptide like other GLP-1 drugs).However, the clock is ticking.Novo Nordisk already has an oral semaglutide to treat type 2 diabetes, sold under the brand name Rybelsus, and they're trialing a high-dose version of that pill that could be approved for weight loss.How it works: The active ingredient in the daily pill is a small molecule which slow digestions and manages blood sugar and insulin, similar to semaglutide (Ozempic, Wegovy).Current research: Results from Phase II trials found that people taking orforglipron lost between 9.4% and 14.7% of their body weight, on average, in 36 weeks.Timeline: Current late-stage trials are expected to last into 2027.Why it's interesting: CagriSema is a once-weekly injection that combines semaglutide (active ingredient in Ozempic and Wegovy) with a compound targeting another hormone, cagrilintide.This combination is expected to help people lose significantly more weight than semaglutide alone, Novo Nordisk says.How it works: Cagrilintide mimics the effects of a naturally-occurring hormone to regulate appetite and digestion and lower blood sugar. CagriSema adds it to the already-popular drug semaglutide, which itself helps manage hunger and blood sugar levels.Novo's chief financial officer said in an earnings call that it would source cagrilintide from a third-party company, which could help with manufacturing. Supply issues and shortages have previously hampered its semaglutide products.Current research: One early study found patients lost more weight on CagriSema (about 15% weight loss over 32 weeks) than either semaglutide or cagrilintide alone.A Novo Nordisk executive told Reuters that projections from the data suggest it could help people lose even more, up to 25% of their weight, over a longer timeline.Timeline: Phase III clinical trials for Cagrisema are ongoing and slated to last until late 2025. The drug could be available in 2026.Why it's interesting: MariTide, from biotech company Amgen, could be a much longer-lasting treatment than current drugs. It only needs to be injected once a month — or even less frequently — compared to the once-weekly requirement for semaglutide and tirzepatide.\"Longer-acting versions of GLP-1 medications offer the potential for greater convenience and potentially improved adherence and sustained use over time,\" McGowan said.The catch is whether side effects might last longer, too.How it works: MariTide is similar to Mounjaro and Zepbound because it mimics GLP-1 and GIP hormones.The difference is that MariTide dials down GIP receptor activity. Amgen says this makes it easier for the body to burn fat.\"This is fascinating because it appears that both enhancing and opposing the GIP receptor influence weight regulation, which speaks to how little is still known about the actual weight-regulating mechanism of certain gut hormones,\" McGowan said.Current research: Patients in a small early-stage study lost 14.5% of body weight on average in 12 weeks. Those who got just a single dose lost an average 8.2% of their body weight.Timeline: Data from Phase II trials is expected later this year, and planning is underway for Phase III trials.","articleSection":"Health","isAccessibleForFree":false,"hasPart":[{"@type":"WebPageElement","isAccessibleForFree":false,"cssSelector":".content-lock-content"}]} </script> <script type="application/ld+json"> {"@context":"http://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https://www.businessinsider.com/","name":"Business Insider"}},{"@type":"ListItem","position":2,"item":{"@id":"https://www.businessinsider.com/health","name":"Health"}},{"@type":"ListItem","position":3,"item":{"@id":"https://www.businessinsider.com/upcoming-glp1-weight-loss-drugs-to-watch-2024-11","name":"5 new weight-loss drugs to watch in the fight for the next Ozempic"}}]} </script> <script>window.allScripts = window.allScripts || []; window.allScripts.push({ type: "load", 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to watch in the fight for the next Ozempic</h1> </section> <section class="byline-wrapper " data-interaction-trigger="legacy-share,save-article,read-in-app-button" > <div class="byline " data-e2e-name="byline" > <div class="byline-content" data-e2e-name="byline-content" > <div class="byline-row"> <div class="byline-author-container"> <div class="byline-author headline-regular"> <span class="" data-e2e-name="Gabby Landsverk" > <a class="byline-link byline-author-name" data-e2e-name="byline-author-name" href="https://www.businessinsider.com/author/gabby-landsverk" >Gabby Landsverk</a></span> </div> <time class="byline-timestamp headline-regular js-date-format" data-timestamp="2024-11-16T10:47:01Z" data-e2e-name="byline-timestamp" data-disable-relative-formatting > 2024-11-16T10:47:01Z </time> </div> </div> </div> </div> <section class="sharebar " data-component-type="legacy-share" data-load-strategy="interaction" data-location="" > <div class="share-button-dropdown-wrapper"> <button 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/ (6720 / 4480))" > <meta itemprop="contentUrl" content="https://i.insider.com/62ff683fec781d001868cdeb?width=700"/> <img src="https://i.insider.com/62ff683fec781d001868cdeb?width=700" srcset="https://i.insider.com/62ff683fec781d001868cdeb?width=400&format=jpeg&auto=webp 400w, https://i.insider.com/62ff683fec781d001868cdeb?width=500&format=jpeg&auto=webp 500w, https://i.insider.com/62ff683fec781d001868cdeb?width=700&format=jpeg&auto=webp 700w, https://i.insider.com/62ff683fec781d001868cdeb?width=1000&format=jpeg&auto=webp 1000w, https://i.insider.com/62ff683fec781d001868cdeb?width=1300&format=jpeg&auto=webp 1300w, https://i.insider.com/62ff683fec781d001868cdeb?width=2000&format=jpeg&auto=webp 2000w" sizes="(min-width: 1280px) 900px" alt="A pill" decoding="sync" /> </div> <span class="image-source-caption with-caption-drawer"> <input class="caption-drawer-input" type="checkbox" id="caption-drawer-checkbox"> <label class="caption-drawer-label" for="caption-drawer-btn"> <svg class="svg-icon chevron-down-icon caption-drawer-icon" role="img" xmlns="http://www.w3.org/2000/svg" width="1em" height="1em" viewBox="0 0 24 24" > <path fill="currentColor" fill-rule="evenodd" d="m19.44 5.5-7.486 7.72L4.56 5.594 2 8.234 11.954 18.5 22 8.14 19.44 5.5Z"/> </svg> </label> <figcaption class="image-caption headline-semibold" data-e2e-name="image-caption" > <span class="image-caption-text">The race is on to make a weight-loss pill that is as effective as injectables like Ozempic, Wegovy, Mounjaro, and Zepbound.</span> <span class="image-source-text"> <span class="image-source headline-regular" data-e2e-name="image-source" itemprop="creditText" > Getty Images </span> </span> </figcaption> </span> </figure> <div class="inline-backup-paywall desktop" data-component-type="inline-backup-paywall" style="display:none"> <span class="headline-semibold subscription-msg">This story is available exclusively to Business Insider subscribers. <a href="/subscription" class="subscription-link">Become an Insider</a> and start reading now.</span> <span class="headline-regular login-prompt">Have an account? <button class="login-prompt-btn">Log in</button>.</span> </div> <div> <section class="post-content typography " data-track-content="" data-post-type="post" > <div id="piano-inline-content-wrapper" data-piano-inline-content-wrapper data-user-status="anonymous" > <div data-component-type="content-lock" data-load-strategy="exclude"> <div class="content-lock-content"> <ul class="summary-list"><li>GLP-1 medications are breakthroughs for weight loss, diabetes, and more.</li><li>Pharma companies are clamoring to produce pills or longer-lasting drugs with faster effects.</li><li>Novo Nordisk, Eli Lilly, Viking Therapeutics and more are publishing promising trial results.</li></ul><p>In the race to find Ozempic 2.0, a few stand-outs are emerging.</p><div class="in-post-sticky only-desktop"><div class="ad-callout-wrapper ad-label headline-medium only-desktop"> <div data-bi-ad="" id="gpt-post-health-desktop_in_post_ad-desktop-fluid-1" class="ad ad-wrapper fluid in-post only-desktop" data-force="" data-type="ad" data-adunit="businessinsider.desktop/post/in-content-1/health" data-secvert="" data-tag="health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen" data-authors="gabby-landsverk" data-region="Desktop In Post Ad" data-responsive="[{"browserLimit":[728,0],"slotSize":[[300,250],"fluid"]},{"browserLimit":[1260,0],"slotSize":[[728,90],[300,250],[800,480],[600,480],"fluid"]}]" data-tile-order="tile-1" data-url="/upcoming-glp1-weight-loss-drugs-to-watch-2024-11" data-template="default" data-targeting="{"adunit":"businessinsider.desktop/post/in-content-1/health","region":"Desktop In Post Ad","tag":"health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen","template":"default","dvp_spos":"in-content-1","rawvert":""}" data-amazontamsizes="[[728,90],[300,250]]" data-not-lazy="" data-enable-ad-refresher="true" data-refresh-count="0"></div> </div></div><p>While <a target="_blank" class="" href="https://www.businessinsider.com/weight-loss-glp-1-drugs-ozempic-wegovy-mounjaro-effects-future-2023-12" data-analytics-product-module="body_link" rel="">GLP-1 drugs</a> have paved the way for a new era of healthcare, they have some drawbacks. They need to be injected (a draw-back for some patients), that injection must be administered once a week for effects to last, and manufacturers struggled to keep up with demand.</p><p>Competition is on the way: Dozens of experimental new weight-loss medications are in development as biotech companies race to get a slice of a <a target="_blank" class="" href="https://www.businessinsider.com/economic-outlook-ozempic-economy-obesity-gdp-productivity-healthcare-novo-nordisk-2024-3" data-analytics-product-module="body_link" rel="">market forecast to be worth $100 billion</a>.</p><div class="in-post-sticky only-desktop"><div class="ad-callout-wrapper ad-label headline-medium only-desktop"> <div data-bi-ad="" id="gpt-post-health-desktop_in_post_ad-desktop-fluid-2" class="ad ad-wrapper fluid in-post only-desktop" data-force="" data-type="ad" data-adunit="businessinsider.desktop/post/in-content-2/health" data-secvert="" data-tag="health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen" data-authors="gabby-landsverk" data-region="Desktop In Post Ad" data-responsive="[{"browserLimit":[728,0],"slotSize":[[300,250],"fluid"]},{"browserLimit":[1260,0],"slotSize":[[728,90],[300,250],[800,480],[600,480],"fluid"]}]" data-tile-order="tile-2" data-url="/upcoming-glp1-weight-loss-drugs-to-watch-2024-11" data-template="default" data-targeting="{"adunit":"businessinsider.desktop/post/in-content-2/health","region":"Desktop In Post Ad","tag":"health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen","template":"default","dvp_spos":"in-content-2","rawvert":""}" data-amazontamsizes="[[728,90],[300,250]]" data-enable-ad-refresher="true" data-refresh-count="0"></div> </div></div><p>Some are combining multiple hormones at once for enhanced effects to regulate appetite, blood sugar, and digestion. Some are trying to package these sought-after ingredients into pill form, or injectables that last longer.</p><p>The next breakthrough drug may not be available until at least 2027, but the leading candidates in production give a good sense of what this market could look like in years to come.</p><p>"Anti-obesity medications are emerging at an astonishing pace," <a target="_blank" class="" href="https://trueyouweightloss.com/about/meet-the-team/dr-christopher-mcgowan/" data-analytics-product-module="body_link" rel=" nofollow">Dr. Christopher McGowan</a>, a gastroenterologist and obesity medicine specialist, told Business Insider. "Forthcoming medications take the blockbuster GLP-1 medications and up the ante."</p><div class="in-post-sticky only-desktop"><div class="ad-callout-wrapper ad-label headline-medium only-desktop"> <div data-bi-ad="" id="gpt-post-health-desktop_in_post_ad-desktop-fluid-3" class="ad ad-wrapper fluid in-post only-desktop" data-force="" data-type="ad" data-adunit="businessinsider.desktop/post/in-content-3/health" data-secvert="" data-tag="health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen" data-authors="gabby-landsverk" data-region="Desktop In Post Ad" data-responsive="[{"browserLimit":[728,0],"slotSize":[[300,250],"fluid"]},{"browserLimit":[1260,0],"slotSize":[[728,90],[300,250],[800,480],[600,480],"fluid"]}]" data-tile-order="tile-3" data-url="/upcoming-glp1-weight-loss-drugs-to-watch-2024-11" data-template="default" data-targeting="{"adunit":"businessinsider.desktop/post/in-content-3/health","region":"Desktop In Post Ad","tag":"health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen","template":"default","dvp_spos":"in-content-3","rawvert":""}" data-amazontamsizes="[[728,90],[300,250]]" data-enable-ad-refresher="true" data-refresh-count="0"></div> </div></div><h2 id="03229fa8-bff6-4bcd-964c-60199e80d187" data-toc-id="03229fa8-bff6-4bcd-964c-60199e80d187"><strong>A new triple-action injection from Eli Lilly</strong></h2><p><strong>Why it's interesting: </strong><a target="_blank" href="https://www.businessinsider.com/new-weight-loss-and-diabetes-drug-retatrutide-awaits-further-testing-2022-12" data-analytics-product-module="body_link" rel="">Retatrutide</a> is a next-gen medication that acts on three different hormones, earning it the nickname <a target="_blank" href="https://www.businessinsider.com/retatrutide-patients-lose-more-weight-than-ozempic-wegovy-mounjaro-2023-6" data-analytics-product-module="body_link" rel="">Triple-G.</a></p><p>That means it could lead to more weight loss than current medications like Ozempic, Wegovy, and Mounjaro, comparable to bariatric surgery.</p><p><strong>How it works: </strong>Eli Lilly's retatrutide drug is administered the same way as the market leaders Ozempic, Wegovy, Mounjaro, and Zepbound: it's a once-weekly injection.</p><div class="in-post-sticky only-desktop"><div class="ad-callout-wrapper ad-label headline-medium only-desktop"> <div data-bi-ad="" id="gpt-post-health-desktop_in_post_ad-desktop-fluid-4" class="ad ad-wrapper fluid in-post only-desktop" data-force="" data-type="ad" data-adunit="businessinsider.desktop/post/in-content-4-plus/health" data-secvert="" data-tag="health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen" data-authors="gabby-landsverk" data-region="Desktop In Post Ad" data-responsive="[{"browserLimit":[728,0],"slotSize":[[300,250],"fluid"]},{"browserLimit":[1260,0],"slotSize":[[728,90],[300,250],[800,480],[600,480],"fluid"]}]" data-tile-order="tile-4" data-url="/upcoming-glp1-weight-loss-drugs-to-watch-2024-11" data-template="default" data-targeting="{"adunit":"businessinsider.desktop/post/in-content-4-plus/health","region":"Desktop In Post Ad","tag":"health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen","template":"default","dvp_spos":"in-content-4-plus","rawvert":""}" data-amazontamsizes="[[728,90],[300,250]]" data-enable-ad-refresher="true" data-refresh-count="0"></div> </div></div><p>What's unique is the substance.</p><p>Like semaglutide (the active ingredient in Ozempic and Wegovy), it works on GLP-1, a hormone that regulates blood sugar and appetite.</p><p>Like tirzepatide (the drug in Mounjaro and Zepbound), it also works on GIP, a hormone that manages blood sugar.</p><div class="in-post-sticky only-desktop"><div class="ad-callout-wrapper ad-label headline-medium only-desktop"> <div data-bi-ad="" id="gpt-post-health-desktop_in_post_ad-desktop-fluid-5" class="ad ad-wrapper fluid in-post only-desktop" data-force="" data-type="ad" data-adunit="businessinsider.desktop/post/in-content-4-plus/health" data-secvert="" data-tag="health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen" data-authors="gabby-landsverk" data-region="Desktop In Post Ad" data-responsive="[{"browserLimit":[728,0],"slotSize":[[300,250],"fluid"]},{"browserLimit":[1260,0],"slotSize":[[728,90],[300,250],[800,480],[600,480],"fluid"]}]" data-tile-order="tile-5" data-url="/upcoming-glp1-weight-loss-drugs-to-watch-2024-11" data-template="default" data-targeting="{"adunit":"businessinsider.desktop/post/in-content-4-plus/health","region":"Desktop In Post Ad","tag":"health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen","template":"default","dvp_spos":"in-content-4-plus","rawvert":""}" data-amazontamsizes="[[728,90],[300,250]]" data-enable-ad-refresher="true" data-refresh-count="0"></div> </div></div><p>Uniquely, retatrutide has an additional effect, mimicking another hormone called glucagon, which may help increase the body's energy use. The idea is that it promotes weight loss by not only curbing appetite, but also burning more calories.</p><p><strong>Current research: </strong>The <a target="_blank" class="" href="https://www.nejm.org/doi/full/10.1056/NEJMoa2301972" data-analytics-product-module="body_link" rel=" nofollow">results of mid-stage trials</a> found that patients taking retatrutide lost an average of 58 pounds in 11 months, more and faster weight loss than has been seen with drugs currently on the market.</p><p><strong>Timeline: </strong>Retatrutide is currently being studied in <a target="_blank" class="" href="https://trials.lilly.com/en-US/trial/405675" data-analytics-product-module="body_link" rel=" nofollow">Phase III trials</a> which are scheduled to be completed in early 2026.</p><div class="in-post-sticky only-desktop"><div class="ad-callout-wrapper ad-label headline-medium only-desktop"> <div data-bi-ad="" id="gpt-post-health-desktop_in_post_ad-desktop-fluid-6" class="ad ad-wrapper fluid in-post only-desktop" data-force="" data-type="ad" data-adunit="businessinsider.desktop/post/in-content-4-plus/health" data-secvert="" data-tag="health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen" data-authors="gabby-landsverk" data-region="Desktop In Post Ad" data-responsive="[{"browserLimit":[728,0],"slotSize":[[300,250],"fluid"]},{"browserLimit":[1260,0],"slotSize":[[728,90],[300,250],[800,480],[600,480],"fluid"]}]" data-tile-order="tile-6" data-url="/upcoming-glp1-weight-loss-drugs-to-watch-2024-11" data-template="default" data-targeting="{"adunit":"businessinsider.desktop/post/in-content-4-plus/health","region":"Desktop In Post Ad","tag":"health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen","template":"default","dvp_spos":"in-content-4-plus","rawvert":""}" data-amazontamsizes="[[728,90],[300,250]]" data-enable-ad-refresher="true" data-refresh-count="0"></div> </div></div><h2 id="e636601d-d064-4676-851b-b8a28f3debbe" data-toc-id="e636601d-d064-4676-851b-b8a28f3debbe"><strong>A faster-acting weight-loss drug that could be a pill or injection</strong></h2><p><strong>Why it's interesting: </strong>Early research suggests <a target="_blank" href="https://www.businessinsider.com/viking-therapeutics-weight-loss-drug-ozempic-glp-1-agonists-2024-2" data-analytics-product-module="body_link" rel="">VK2735</a>, from California-based Viking Therapeutics, could work faster than competitors like semaglutide and tirzepatide.</p> <section class="dad-related-posts-component at-inline related-posts" data-component-type="dad-related-posts" data-delay-third-party-scripts="true" data-size="2" data-container-index="in_content_recirc_1" data-included-verticals="health" data-placement="inline" data-excluded-verticals="bi-video" data-root-margin="250px 0px" data-track-view="{"event":"module_in_view","element_name":"in_content_recirc","subscription_experience":"bi_value_unassigned","product_field":"in_content_recirc_1"}"> <div class="content-recommendations-title-container"> <h2 class="content-recommendations-title display-xs ignore-typography"> Related stories </h2> </div> <div class="dad-related-posts-container"></div> </section> <p><strong>How it works:</strong> VK2735 acts on both GLP-1 and GIP, similar to tirzepatide (the active ingredient in Mounjaro and Zepbound).</p><p>It's being tested in pill form as well as a once-weekly injection.</p><div class="in-post-sticky only-desktop"><div class="ad-callout-wrapper ad-label headline-medium only-desktop"> <div data-bi-ad="" id="gpt-post-health-desktop_in_post_ad-desktop-fluid-7" class="ad ad-wrapper fluid in-post only-desktop" data-force="" data-type="ad" data-adunit="businessinsider.desktop/post/in-content-4-plus/health" data-secvert="" data-tag="health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen" data-authors="gabby-landsverk" data-region="Desktop In Post Ad" data-responsive="[{"browserLimit":[728,0],"slotSize":[[300,250],"fluid"]},{"browserLimit":[1260,0],"slotSize":[[728,90],[300,250],[800,480],[600,480],"fluid"]}]" data-tile-order="tile-7" data-url="/upcoming-glp1-weight-loss-drugs-to-watch-2024-11" data-template="default" data-targeting="{"adunit":"businessinsider.desktop/post/in-content-4-plus/health","region":"Desktop In Post Ad","tag":"health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen","template":"default","dvp_spos":"in-content-4-plus","rawvert":""}" data-amazontamsizes="[[728,90],[300,250]]" data-enable-ad-refresher="true" data-refresh-count="0"></div> </div></div><p><strong>Current research: </strong>A <a target="_blank" class="" href="https://ir.vikingtherapeutics.com/2024-02-27-Viking-Therapeutics-Announces-Positive-Top-Line-Results-from-Phase-2-VENTURE-Trial-of-Dual-GLP-1-GIP-Receptor-Agonist-VK2735-in-Patients-with-Obesity" data-analytics-product-module="body_link" rel=" nofollow">mid-stage trial</a> found patients on VK2735 lost an average of 14.7% of their body weight (about 32 pounds) by 13 weeks.</p><p>It hasn't been directly tested against other medications but the results are comparable to what we've seen in trials of semaglutide (Ozempic, Wegovy) after 68 weeks. That suggests similar weight loss but in a fraction of the time.</p><p><strong>Timeline:</strong> Viking Therapeutics <a target="_blank" class="" href="https://ir.vikingtherapeutics.com/2024-10-23-Viking-Therapeutics-Reports-Third-Quarter-2024-Financial-Results-and-Provides-Corporate-Update" data-analytics-product-module="body_link" rel=" nofollow">recently announced</a> it would meet with the FDA about the end of Phase II for VK2735 injections before 2025. The oral form of VK2735 is expected to enter Phase II trials by the end of this year, too.</p><div class="in-post-sticky only-desktop"><div class="ad-callout-wrapper ad-label headline-medium only-desktop"> <div data-bi-ad="" id="gpt-post-health-desktop_in_post_ad-desktop-fluid-8" class="ad ad-wrapper fluid in-post only-desktop" data-force="" data-type="ad" data-adunit="businessinsider.desktop/post/in-content-4-plus/health" data-secvert="" data-tag="health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen" data-authors="gabby-landsverk" data-region="Desktop In Post Ad" data-responsive="[{"browserLimit":[728,0],"slotSize":[[300,250],"fluid"]},{"browserLimit":[1260,0],"slotSize":[[728,90],[300,250],[800,480],[600,480],"fluid"]}]" data-tile-order="tile-8" data-url="/upcoming-glp1-weight-loss-drugs-to-watch-2024-11" data-template="default" data-targeting="{"adunit":"businessinsider.desktop/post/in-content-4-plus/health","region":"Desktop In Post Ad","tag":"health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen","template":"default","dvp_spos":"in-content-4-plus","rawvert":""}" data-amazontamsizes="[[728,90],[300,250]]" data-enable-ad-refresher="true" data-refresh-count="0"></div> </div></div><h2 id="77bb7c6c-1d1d-424d-aa59-728b114c2d15" data-toc-id="77bb7c6c-1d1d-424d-aa59-728b114c2d15"><strong>Eli Lilly is racing to get the first weight-loss pill on the market</strong></h2><p><strong>Why it's interesting: </strong>Eli Lilly may beat Viking Therapeutics to get the first oral GLP-1 to market.</p><p>Their drug orforglipron appeals to patients who can't or don't want to use injected medications. It is also expected to be cheaper, since it's easier to produce (orforglipron isn't a <a target="_blank" class="" href="https://www.businessinsider.com/peptides-growth-hormone-hgh-new-health-fad-2023-9" data-analytics-product-module="body_link" rel="">peptide</a> like other GLP-1 drugs).</p><p>However, the clock is ticking.</p><div class="in-post-sticky only-desktop"><div class="ad-callout-wrapper ad-label headline-medium only-desktop"> <div data-bi-ad="" id="gpt-post-health-desktop_in_post_ad-desktop-fluid-9" class="ad ad-wrapper fluid in-post only-desktop" data-force="" data-type="ad" data-adunit="businessinsider.desktop/post/in-content-4-plus/health" data-secvert="" data-tag="health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen" data-authors="gabby-landsverk" data-region="Desktop In Post Ad" data-responsive="[{"browserLimit":[728,0],"slotSize":[[300,250],"fluid"]},{"browserLimit":[1260,0],"slotSize":[[728,90],[300,250],[800,480],[600,480],"fluid"]}]" data-tile-order="tile-9" data-url="/upcoming-glp1-weight-loss-drugs-to-watch-2024-11" data-template="default" data-targeting="{"adunit":"businessinsider.desktop/post/in-content-4-plus/health","region":"Desktop In Post Ad","tag":"health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen","template":"default","dvp_spos":"in-content-4-plus","rawvert":""}" data-amazontamsizes="[[728,90],[300,250]]" data-enable-ad-refresher="true" data-refresh-count="0"></div> </div></div><p>Novo Nordisk already has an oral semaglutide to treat type 2 diabetes, sold under the brand name Rybelsus, and they're trialing a <a target="_blank" class="" href="https://www.businessinsider.com/ozempic-pill-semaglutide-helped-overweight-people-lose-weight-in-trial-2023-5" data-analytics-product-module="body_link" rel="">high-dose version of that pill that could be approved for weight loss</a>.</p><p><strong>How it works: </strong>The active ingredient in the daily pill is a small molecule which slow digestions and manages blood sugar and insulin, similar to semaglutide (Ozempic, Wegovy).</p><p><strong>Current research: </strong><a target="_blank" class="" href="https://www.nejm.org/doi/full/10.1056/NEJMoa2302392" data-analytics-product-module="body_link" rel=" nofollow">Results from Phase II trials</a> found that people taking orforglipron lost between 9.4% and 14.7% of their body weight, on average, in 36 weeks.</p><div class="in-post-sticky only-desktop"><div class="ad-callout-wrapper ad-label headline-medium only-desktop"> <div data-bi-ad="" id="gpt-post-health-desktop_in_post_ad-desktop-fluid-10" class="ad ad-wrapper fluid in-post only-desktop" data-force="" data-type="ad" data-adunit="businessinsider.desktop/post/in-content-4-plus/health" data-secvert="" data-tag="health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen" data-authors="gabby-landsverk" data-region="Desktop In Post Ad" data-responsive="[{"browserLimit":[728,0],"slotSize":[[300,250],"fluid"]},{"browserLimit":[1260,0],"slotSize":[[728,90],[300,250],[800,480],[600,480],"fluid"]}]" data-tile-order="tile-10" data-url="/upcoming-glp1-weight-loss-drugs-to-watch-2024-11" data-template="default" data-targeting="{"adunit":"businessinsider.desktop/post/in-content-4-plus/health","region":"Desktop In Post Ad","tag":"health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen","template":"default","dvp_spos":"in-content-4-plus","rawvert":""}" data-amazontamsizes="[[728,90],[300,250]]" data-enable-ad-refresher="true" data-refresh-count="0"></div> </div></div><p><strong>Timeline:</strong> Current <a target="_blank" class="" href="https://clinicaltrials.gov/study/NCT05869903" data-analytics-product-module="body_link" rel="">late-stage trials</a> are expected to last into 2027.</p><h2 id="1e386d6d-423a-4b83-b3c7-70231a9cd219" data-toc-id="1e386d6d-423a-4b83-b3c7-70231a9cd219"><strong>Novo Nordisk is touting a stronger alternative to Ozempic that may be easier to produce at scale</strong></h2><p><strong>Why it's interesting: </strong>CagriSema is a once-weekly injection that combines semaglutide (active ingredient in Ozempic and Wegovy) with a compound targeting another hormone, cagrilintide.</p><p>This combination is expected to help people lose significantly more weight than semaglutide alone, Novo Nordisk says.</p><div class="in-post-sticky only-desktop"><div class="ad-callout-wrapper ad-label headline-medium only-desktop"> <div data-bi-ad="" id="gpt-post-health-desktop_in_post_ad-desktop-fluid-11" class="ad ad-wrapper fluid in-post only-desktop" data-force="" data-type="ad" data-adunit="businessinsider.desktop/post/in-content-4-plus/health" data-secvert="" data-tag="health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen" data-authors="gabby-landsverk" data-region="Desktop In Post Ad" data-responsive="[{"browserLimit":[728,0],"slotSize":[[300,250],"fluid"]},{"browserLimit":[1260,0],"slotSize":[[728,90],[300,250],[800,480],[600,480],"fluid"]}]" data-tile-order="tile-11" data-url="/upcoming-glp1-weight-loss-drugs-to-watch-2024-11" data-template="default" data-targeting="{"adunit":"businessinsider.desktop/post/in-content-4-plus/health","region":"Desktop In Post Ad","tag":"health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen","template":"default","dvp_spos":"in-content-4-plus","rawvert":""}" data-amazontamsizes="[[728,90],[300,250]]" data-enable-ad-refresher="true" data-refresh-count="0"></div> </div></div><p><strong>How it works: </strong>Cagrilintide mimics the effects of a naturally-occurring hormone to regulate appetite and digestion and lower blood sugar. CagriSema adds it to the already-popular drug semaglutide, which itself helps manage hunger and blood sugar levels.</p><p>Novo's chief financial officer said in an earnings call that it would source cagrilintide from a third-party company, which could help with manufacturing. Supply issues and <a target="_blank" class="" href="https://www.businessinsider.com/buy-compounded-semaglutide-online-risks-wegovy-ozempic-2023-1" data-analytics-product-module="body_link" rel="">shortages</a> have previously hampered its semaglutide products.</p><p><strong>Current research: </strong>One <a target="_blank" class="" href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01163-7/abstract" data-analytics-product-module="body_link" rel=" nofollow">early study</a> found patients lost more weight on CagriSema (about 15% weight loss over 32 weeks) than either semaglutide or cagrilintide alone.</p><div class="in-post-sticky only-desktop"><div class="ad-callout-wrapper ad-label headline-medium only-desktop"> <div data-bi-ad="" id="gpt-post-health-desktop_in_post_ad-desktop-fluid-12" class="ad ad-wrapper fluid in-post only-desktop" data-force="" data-type="ad" data-adunit="businessinsider.desktop/post/in-content-4-plus/health" data-secvert="" data-tag="health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen" data-authors="gabby-landsverk" data-region="Desktop In Post Ad" data-responsive="[{"browserLimit":[728,0],"slotSize":[[300,250],"fluid"]},{"browserLimit":[1260,0],"slotSize":[[728,90],[300,250],[800,480],[600,480],"fluid"]}]" data-tile-order="tile-12" data-url="/upcoming-glp1-weight-loss-drugs-to-watch-2024-11" data-template="default" data-targeting="{"adunit":"businessinsider.desktop/post/in-content-4-plus/health","region":"Desktop In Post Ad","tag":"health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen","template":"default","dvp_spos":"in-content-4-plus","rawvert":""}" data-amazontamsizes="[[728,90],[300,250]]" data-enable-ad-refresher="true" data-refresh-count="0"></div> </div></div><p>A Novo Nordisk executive told <a target="_blank" class="" href="https://www.reuters.com/business/healthcare-pharmaceuticals/novo-nordisk-says-its-experimental-drug-cagrisema-has-similar-side-effects-2024-11-06/" data-analytics-product-module="body_link" rel=" nofollow">Reuters</a> that projections from the data suggest it could help people lose even more, up to 25% of their weight, over a longer timeline.</p><p><strong>Timeline: </strong>Phase III clinical trials for Cagrisema are ongoing and slated to last until late 2025. The drug could be available in 2026.</p><h2 id="f9e2452f-a8fe-47e5-a61d-209a3b2b28b3" data-toc-id="f9e2452f-a8fe-47e5-a61d-209a3b2b28b3"><strong>A longer-lasting monthly shot from Amgen</strong></h2><p><strong>Why it's interesting: </strong>MariTide, from biotech company Amgen, could be a much longer-lasting treatment than current drugs. It only needs to be injected once a month — or even less frequently — compared to the once-weekly requirement for semaglutide and tirzepatide.</p><div class="in-post-sticky only-desktop"><div class="ad-callout-wrapper ad-label headline-medium only-desktop"> <div data-bi-ad="" id="gpt-post-health-desktop_in_post_ad-desktop-fluid-13" class="ad ad-wrapper fluid in-post only-desktop" data-force="" data-type="ad" data-adunit="businessinsider.desktop/post/in-content-4-plus/health" data-secvert="" data-tag="health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen" data-authors="gabby-landsverk" data-region="Desktop In Post Ad" data-responsive="[{"browserLimit":[728,0],"slotSize":[[300,250],"fluid"]},{"browserLimit":[1260,0],"slotSize":[[728,90],[300,250],[800,480],[600,480],"fluid"]}]" data-tile-order="tile-13" data-url="/upcoming-glp1-weight-loss-drugs-to-watch-2024-11" data-template="default" data-targeting="{"adunit":"businessinsider.desktop/post/in-content-4-plus/health","region":"Desktop In Post Ad","tag":"health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen","template":"default","dvp_spos":"in-content-4-plus","rawvert":""}" data-amazontamsizes="[[728,90],[300,250]]" data-enable-ad-refresher="true" data-refresh-count="0"></div> </div></div><p>"Longer-acting versions of GLP-1 medications offer the potential for greater convenience and potentially improved adherence and sustained use over time," McGowan said.</p><p>The catch is whether side effects might last longer, too.</p><p><strong>How it works: </strong>MariTide is similar to Mounjaro and Zepbound because it mimics GLP-1 and GIP hormones.</p><div class="in-post-sticky only-desktop"><div class="ad-callout-wrapper ad-label headline-medium only-desktop"> <div data-bi-ad="" id="gpt-post-health-desktop_in_post_ad-desktop-fluid-14" class="ad ad-wrapper fluid in-post only-desktop" data-force="" data-type="ad" data-adunit="businessinsider.desktop/post/in-content-4-plus/health" data-secvert="" data-tag="health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen" data-authors="gabby-landsverk" data-region="Desktop In Post Ad" data-responsive="[{"browserLimit":[728,0],"slotSize":[[300,250],"fluid"]},{"browserLimit":[1260,0],"slotSize":[[728,90],[300,250],[800,480],[600,480],"fluid"]}]" data-tile-order="tile-14" data-url="/upcoming-glp1-weight-loss-drugs-to-watch-2024-11" data-template="default" data-targeting="{"adunit":"businessinsider.desktop/post/in-content-4-plus/health","region":"Desktop In Post Ad","tag":"health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen","template":"default","dvp_spos":"in-content-4-plus","rawvert":""}" data-amazontamsizes="[[728,90],[300,250]]" data-enable-ad-refresher="true" data-refresh-count="0"></div> </div></div><p>The difference is that MariTide dials down GIP receptor activity. Amgen says this makes it easier for the body to burn fat.</p><p>"This is fascinating because it appears that both enhancing and opposing the GIP receptor influence weight regulation, which speaks to how little is still known about the actual weight-regulating mechanism of certain gut hormones," McGowan said.</p><p><strong>Current research: </strong>Patients in a <a target="_blank" href="https://affiliate.insider.com/?h=e053792e27a615fb7dda56aa0745b0c87c4f95e380ec169abcf45f1d1b11336c&platform=browser&postID=673380d5d057d3e5c5d03443&postSlug=upcoming-glp1-weight-loss-drugs-to-watch-2024-11&site=bi&u=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs42255-023-00966-w" data-autoaffiliated="true" data-analytics-product-module="body_link" rel="nofollow sponsored noindex" data-am-orig-url="https://affiliate.insider.com/?h=e053792e27a615fb7dda56aa0745b0c87c4f95e380ec169abcf45f1d1b11336c&u=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs42255-023-00966-w">small early-stage study</a> lost 14.5% of body weight on average in 12 weeks. Those who got just a single dose lost an average 8.2% of their body weight.</p><div class="in-post-sticky only-desktop"><div class="ad-callout-wrapper ad-label headline-medium only-desktop"> <div data-bi-ad="" id="gpt-post-health-desktop_in_post_ad-desktop-fluid-15" class="ad ad-wrapper fluid in-post only-desktop" data-force="" data-type="ad" data-adunit="businessinsider.desktop/post/in-content-4-plus/health" data-secvert="" data-tag="health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen" data-authors="gabby-landsverk" data-region="Desktop In Post Ad" data-responsive="[{"browserLimit":[728,0],"slotSize":[[300,250],"fluid"]},{"browserLimit":[1260,0],"slotSize":[[728,90],[300,250],[800,480],[600,480],"fluid"]}]" data-tile-order="tile-15" data-url="/upcoming-glp1-weight-loss-drugs-to-watch-2024-11" data-template="default" data-targeting="{"adunit":"businessinsider.desktop/post/in-content-4-plus/health","region":"Desktop In Post Ad","tag":"health,weight-loss,glp-1,semaglutide,vk2735,eli-lilly,novo-nordisk,amgen","template":"default","dvp_spos":"in-content-4-plus","rawvert":""}" data-amazontamsizes="[[728,90],[300,250]]" data-enable-ad-refresher="true" data-refresh-count="0"></div> </div></div><p><strong>Timeline: </strong>Data from Phase II trials is <a target="_blank" class="" href="https://www.amgen.com/newsroom/press-releases/2024/10/amgen-reports-third-quarter-2024-financial-results" data-analytics-product-module="body_link" rel=" nofollow">expected later this year</a>, and planning is underway for Phase III trials.</p> </div> </div> </div> </section> </div> <section class="post-content-more"> <section class="dad-related-posts-component at-post-bottom related-posts standard" data-component-type="dad-related-posts" data-delay-third-party-scripts="true" data-size="4" data-container-index="" data-included-verticals="health" data-placement="post-bottom" data-excluded-verticals="bi-video" data-root-margin="250px 0px" data-track-view="{"element_name":"end_of_article_recirc","product_field":"bi_value_unassigned","subscription_experience":"bi_value_unassigned"}" > <div class="content-recommendations-title-container"> <h2 class="content-recommendations-title display-xs ignore-typography"> Read next </h2> </div> <div class="dad-related-posts-container"></div> </section> </section> <div class="post-category-tags" data-component-type="post-category-tags" data-load-strategy="lazy"> <ul class="post-category-tags-list headline-semibold" data-track-click-shared="{"product_field":"bi_value_unassigned","event":"navigation","element_name":"category_link"}" > <li class="post-category-tag"> <a data-track-click href="/category/health" class="post-category-link">Health</a> </li> <li class="post-category-tag"> <a data-track-click href="/category/weight-loss" class="post-category-link">Weight Loss</a> </li> <li class="post-category-tag"> <a data-track-click href="/category/semaglutide" 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