HD IL-2 should be considered for patients with melanoma brain metastases

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</li> <li class=""> <a class="" href="/web/20140119143214/http://www.healio.com/hematology-oncology/meetings/{ead2ef73-a0d2-4eed-96b1-5021a03e8306}/san-antonio-breast-cancer-symposium" title="News" target=""> San Antonio Breast Cancer Symposium</a> </li> <li class="first"> <a class="all" href="/web/20140119143214/http://www.healio.com/hematology-oncology/meetings/meeting-news-coverage" title="News" target=""> Meeting News Coverage</a> </li> </ul> </li> <li><a href="/web/20140119143214/http://www.healio.com/hematology-oncology/careers" title="Careers" target=""> Careers</a> <ul class="sub_menu"> </ul> </li> </ul> <script type="text/javascript"> jQuery(".nav>li:last>a").addClass("last"); //fix for IE last-child style </script>   <div id="main-content">  <p id="breadcrumbs"> <a href="/web/20140119143214/http://www.healio.com/"> Healio</a> <span>›</span> <a href="/web/20140119143214/http://www.healio.com/hematology-oncology"> Hematology/Oncology</a> <span>›</span> <a href="/web/20140119143214/http://www.healio.com/hematology-oncology/hemonc-today-melanoma"> Highlights from HemOnc Today Melanoma 2013</a> <span>›</span> <a href="/web/20140119143214/http://www.healio.com/hematology-oncology/hemonc-today-melanoma/hd-il-2-should-be-considered-for-patients-with-melanoma-brain-metastases"> HD IL-2 should be considered for patients with melanoma brain metastases</a> </p>  <script language="javascript" type="text/javascript"> $j(document).ready(function () { var submitbtn = $j('*[id^="pd-vote-button"]'); $j(submitbtn).click(function () { show_confirm(); }); }); function AjaxFailed(result) { alert(result.status + " " + result.statusText + " " + result.responseText); } function AjaxSucceeded(result) { } function show_confirm() { var selectrb = $j('input[id^="PDI_answer"]:radio:checked') var answerid = $j(selectrb).attr("value"); var testid = $j(selectrb).attr("name"); var userid = $j("#contactid").attr("value"); data = { 'userid': userid, 'testid': testid, 'answerid': answerid }; $j.ajax({ type: "POST", url: "https://web.archive.org/web/20140119143214/http://www.healio.com/webservices/CaptureRecord.asmx/savePollAnswer", contentType: "application/json; charset=utf-8", dataType: "json", data: JSON.stringify(data), success: function (msg) { AjaxSucceeded(msg); }, error: function (emsg) { AjaxFailed(emsg); } }); } </script> <link href="/web/20140119143214cs_/http://www.healio.com/~/media/Images/Resource Centers/HemOnc/2013 HOT Melanoma/RC_HOT_Melanoma.css" rel="stylesheet" type="text/css"/> <input type="hidden" id="contactid" value="{0}"/> <div class="resource-wrap"> <a href="/web/20140119143214/http://www.healio.com/hematology-oncology/hemonc-today-melanoma"><img src="/web/20140119143214im_/http://www.healio.com/~/media/Images/Resource Centers/Melanoma_Banner.jpg" alt="Highlights from HemOncToday Melanoma and Cutaneous Malignancies" border="0"/></a> <h2></h2>  <div class="content"> <h2> HD IL-2 should be considered for patients with melanoma brain metastases</h2> <h3 class="deck"> </h3> <p class="main-subtitle"> </p> <div class="social-links-top"> <ul class="share"> <li class="l1"><a href="javascript:void(0)" class="facebook-link" target="_new">Facebook</a></li> <li class="l2"><a href="javascript:void(0)" class="twitter-link" target="_new">Tweet</a></li> <li class="l3"><a href="javascript:void(0)" class="linkedin-link">Share</a></li> </ul> </div> <ul class="meta-info"> <li> HemOnc Today, April 25, 2013</li> </ul> <div class="wyContent"> <p class="Bodytext1">NEW YORK — Patients with melanoma who have brain metastases should not be considered ineligible for treatment with high-dose interleukin-2, according to study results presented at the <em>HemOnc Today</em> Melanoma and Cutaneous Malignancies meeting.</p> <p class="Bodytext">The FDA approved high-dose interleukin-2 (HD IL-2) in 1998 for treatment of metastatic melanoma.</p> <div class="mug right"><img width="90" height="119" alt="Melinda Chu, MD" src="/web/20140119143214im_/http://www.healio.com/~/media/Images/Mugs/HemOnc/C/Chu_Melinda.JPG"/>  <p class="name"><strong><strong>Melinda B. Chu</strong></strong></p> </div> <p class="Bodytext"></p> <p class="Bodytext">“Traditionally, patients with brain metastasis have been thought to be ineligible for high-dose IL-2 treatment because of concerns about life-threatening cerebral edema and neurotoxicity,” <strong>Melinda B. Chu, MD</strong>, a dermatology resident at Saint Louis University, told <em>HemOnc Today</em>. </p> <p class="Bodytext">However, patients with melanoma brain metastases who were treated by <strong>John M. Richart, MD</strong>, at Saint Louis University Cancer Center demonstrated high performance status, met all other criteria and were deemed eligible for treatment with HD IL-2.</p> <p class="Bodytext">To evaluate outcomes among this patient population, Chu and colleagues performed a retrospective chart review on eight melanoma patients with stable brain disease — metastatic lesions that did not require steroids nor cause neurological deficits — who underwent treatment with HD IL-2 between 1999 and 2011. </p> <p class="Bodytext">Five of the patients were men. The median patient age was 52.2 years (range, 26.8 to 61.1 years). One patient started treatment with metastatic lung lesions after complete resection of a melanoma brain lesion. The other seven patients had brain metastases at the time of treatment initiation.</p> <p class="Bodytext">The treatment regimen, administered before and after radiosurgery or radiation, consisted of 720,000 IU/kg per dose IV for 14 doses, with two cycles per course for a maximum of two courses.</p> <p class="Bodytext">Prior studies showed median OS for patients with melanoma brain metastases is approximately 4 months. In this analysis, median OS for all patients was 8.7 months (range, 2.1 to 19 months).</p> <p class="Bodytext">All seven patients with brain metastases showed progressive disease. Median OS among those patients was 6.7 months (range, 2.1 to 18.2 months).</p> <p class="Bodytext">The patient who began HD IL-2 therapy with metastatic disease limited to the lungs underwent resection of the residual lung lesion and was deemed to show surgical complete response.</p> <p class="Bodytext">The researchers observed no treatment-related mortality, and no patients were transferred to the ICU, Chu said.</p> <p class="Bodytext">One patient developed symptoms suggestive of neurotoxicity. When researchers learned the patient had a history of alcohol abuse, she began an alcohol withdrawal protocol. The patient’s symptoms improved, allowing HD IL-2 treatment to continue.</p> <p class="Bodytext">“The findings suggest patients with stable brain metastases who are otherwise eligible for therapy should not be excluded from high-dose IL-2 treatment,” Chu said.</p> <p class="Bodytext"><strong>For more information:</strong></p> <p style="margin: 4pt 0in 0pt;" class="references">Chu MB. Abstract #5. 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HD IL-2 should be considered for patients with melanoma brain metastases