PDB-101: Goodsell Gallery: SARS-CoV-2 mRNA Vaccine

<!DOCTYPE html> <html> <head> <script src="https://www.googletagmanager.com/gtag/js?id=G-EPQ9202NVY" async></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); //- gtag('config', 'UA-71059016-1'); gtag('config', 'G-EPQ9202NVY'); </script> <title>PDB-101: Goodsell Gallery: SARS-CoV-2 mRNA Vaccine</title> <meta charset="utf-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="viewport" content="width=device-width, initial-scale=1"> <meta property="og:title" content="PDB101: Goodsell Gallery: SARS-CoV-2 mRNA Vaccine"> <meta property="og:description" content="This illustration depicts an idealized mRNA vaccine against SARS-CoV-2."> <meta property="og:image" content="https://cdn.rcsb.org/pdb101/goodsell/png-400/sars-cov-2-mrna-vaccine.png"> <meta property="og:site_name" content="RCSB: PDB-101"> <meta name="twitter:card" content="summary"> <meta name="twitter:title" content="PDB101: Goodsell Gallery: SARS-CoV-2 mRNA Vaccine"> <meta name="twitter:description" content="This illustration depicts an idealized mRNA vaccine against SARS-CoV-2."> <meta name="twitter:image" content="https://cdn.rcsb.org/pdb101/goodsell/png-400/sars-cov-2-mrna-vaccine.png"> <meta name="description" content="This illustration depicts an idealized mRNA vaccine against SARS-CoV-2."> <meta name="keywords" content="SARS-CoV-2,COVID19,virus,immunity,immune system,vaccine,mRNA vaccine">  <meta name="google-site-verification" content="A8M31jAX8SUgQYzbnF5r-wgykna2i5Hp4J9fziVD9Sg"> <link href="https://cdn.rcsb.org/pdb101/common/jquery-ui-1.11.4/jquery-ui.min.css" rel="stylesheet"> <link href="https://cdn.rcsb.org/javascript/bootstrap/latest/css/bootstrap.min.css" rel="stylesheet"> <link href="/ekko-lightbox/ekko-lightbox.css" rel="stylesheet"> <link href="https://cdn.rcsb.org/javascript/fontawesome/latest/css/font-awesome.min.css" rel="stylesheet"> <link href="https://cdn.rcsb.org/javascript/timeline3/css/timeline.css" rel="stylesheet"> <link href="/css/style.css?v=20171201" rel="stylesheet"> <link href="https://cdn.rcsb.org/jira-feedback/css/jira-fdbck.css" rel="stylesheet"> <script src="https://cdn.rcsb.org/javascript/jquery/jquery-2.2.4.min.js"></script> <script src="https://cdn.rcsb.org/pdb101/common/jquery-ui-1.11.4/jquery-ui.min.js"></script> <script src="https://cdn.rcsb.org/javascript/bootstrap/latest/js/bootstrap.min.js"></script> <script src="/ekko-lightbox/ekko-lightbox.min.js"></script> <script src="/js/common.js"></script> <script src="https://cdn.rcsb.org/jira-feedback/js/jira-fdbck.min.js"></script> </head> <body> <div data-elastic-exclude> <nav class="navbar navbar-inverse navbar-fixed-top hidden-print"> <div class="container"> <div class="navbar-header"> <button type="button" data-toggle="collapse" data-target="#navbar" aria-expanded="false" aria-controls="navbar" class="navbar-toggle collapsed"><span class="sr-only">Toggle navigation</span><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button><a href="/" class="navbar-brand">PDB-101</a> </div> <div id="navbar" class="collapse navbar-collapse"> <ul class="nav navbar-nav"> <li class="dropdown"><a href="#" data-toggle="dropdown" class="dropdown-toggle"><span class="hidden-sm hidden-xs">Molecule of the Month</span><span class="hidden-lg hidden-md">MotM</span><b class="caret"></b></a> <ul class="dropdown-menu"> <li><a href="/motm">Current Feature</a></li> <li><a href="/motm/motm-by-category">By Category</a></li> <li><a href="/motm/motm-by-date">By Date</a></li> <li><a href="/motm/motm-by-title">By Title</a></li> <li><a href="/motm/motm-about">About Molecule of the Month</a></li> <li><a href="/motm/motm-image-download">Image Download</a></li> <li><a href="https://my.forms.app/rcsb-pdb/motm-newsletter" target="_blank">Newsletter Subscription</a></li> </ul> </li> <li><a href="/browse">Browse</a></li> <li class="dropdown"><a href="#" data-toggle="dropdown" class="dropdown-toggle">Learn<b class="caret"></b></a> <ul class="dropdown-menu"> <li><a href="/learn/paper-models">Paper Models</a></li> <li><a href="/learn/flyers-posters-and-calendars">Flyers, Posters, & Calendars</a></li> <li><a href="/learn/videos">Videos</a></li> <li><a href="/learn/interactive-animations">Interactive Animations</a></li> <li><a href="/learn/coloring-books">Coloring Books</a></li> <li><a href="/learn/structural-biology-highlights">Structural Biology Highlights</a></li> <li><a href="/learn/3d-printing">3D Printing</a></li> <li><a href="/learn/exploring-the-structural-biology-of-cancer">Exploring the Structural Biology of Cancer</a></li> <li><a href="/learn/exploring-the-structural-biology-of-bioenergy">Exploring the Structural Biology of Bioenergy</a></li> <li><a href="/learn/exploring-the-structural-biology-of-viruses">Exploring the Structural Biology of Viruses</a></li> <li><a href="/learn/exploring-the-structural-biology-of-health-and-nutrition">Exploring the Structural Biology of Health and Nutrition</a></li> <li><a href="/learn/exploring-the-structural-biology-of-evolution">Exploring the Structural Biology of Evolution</a></li> <li><a href="/learn/exploring-structural-biology-with-computed-structure-models-csms">Exploring Structural Biology with Computed Structure Models (CSMs)</a></li> <li><a href="/learn/resources-to-fight-the-covid-19-pandemic">COVID-19 Pandemic Resources</a></li> <li><a href="/learn/other-resources">Other Resources</a></li> </ul> </li> <li class="dropdown"> <a href="#" data-toggle="dropdown" class="dropdown-toggle">Train <b class="caret"></b></a> <ul class="dropdown-menu"> <li><a href="/train/guide-to-understanding-pdb-data/introduction">Guide to Understanding PDB Data</a></li> <li><a href="/train/training-events">Training Courses</a></li> <li><a href="/train/education-corner">Education Corner</a></li> <li><a href="/train/pdb-and-data-archiving-curriculum/about">PDB and Data Archiving Curriculum</a></li> </ul> </li> <li class="dropdown"><a href="#" data-toggle="dropdown" class="dropdown-toggle">Teach<b class="caret"></b></a> <ul class="dropdown-menu"> <li><a href="/teach/overview">Overview of Curriculum Modules</a></li> <li role="separator" class="divider"></li>  <li><a href="/teach/biomolecular-structures-and-models" style="text-indent: 20px;">Biomolecular Structures and Models</a></li> <li><a href="/teach/covid-19/topics/getting-started-hand-washing" style="text-indent: 20px;">COVID-19 in Molecular Detail</a></li> <li><a href="/teach/diabetes-at-a-molecular-level" style="text-indent: 20px;">Diabetes at a Molecular Level</a></li> <li><a href="/teach/molecular-immunology" style="text-indent: 20px;">Molecular Immunology</a></li> <li><a href="/teach/molecular-view-of-hiv-aids" style="text-indent: 20px;">Molecular View of HIV/AIDS</a></li> <li><a href="/teach/box-of-lessons/topics/biological-macromolecules" style="text-indent: 20px;">Box of Lessons</a></li> </ul> </li> <li class="dropdown"><a href="#" data-toggle="dropdown" class="dropdown-toggle"><span class="hidden-sm hidden-xs">Global Health</span><span class="hidden-lg hidden-md">Health</span><b class="caret"></b></a> <ul class="dropdown-menu"> <li><a href="/global-health/diabetes-mellitus/about/what-is-diabetes">Diabetes Mellitus</a></li> <li><a href="/global-health/cancer/about/what-is-cancer">Cancer </a></li> </ul> </li> <li class="dropdown"><a href="#" data-toggle="dropdown" class="dropdown-toggle">SciArt<b class="caret"></b></a> <ul class="dropdown-menu"> <li><a href="/sci-art/geis-archive/about">Irving Geis</a></li> <li><a href="/sci-art/goodsell-gallery">David Goodsell</a></li> <li><a href="/sci-art/bezsonova-gallery">Irina Bezsonova</a></li> </ul> </li> <li class="dropdown"><a href="#" data-toggle="dropdown" class="dropdown-toggle">Events<b class="caret"></b></a> <ul class="dropdown-menu"> <li><a href="/events/art-of-science">Art of Science</a></li> <li><a href="http://www.rcsb.org/pages/awards/poster_prize" target="_blank">Poster Prize </a></li> <p style="font-size: 90%; margin: 8px 15px 0 20px; font-weight: bold; margin-bottom: 0; border-top: 1px solid #ddd; padding-top: 5px">Past events</p> <li><a href="https://www.rcsb.org/pages/pdb50" target="_blank"> PDB50</a></li> <li><a href="/events/science-olympiad">Science Olympiad</a></li> <li><a href="/events/video-challenge/the-challenge">Video Challenge</a></li> </ul> </li> <li class="dropdown"><a href="#" data-toggle="dropdown" class="dropdown-toggle">About<b class="caret"></b></a> <ul class="dropdown-menu"> <li><a href="/more/about-pdb-101">About PDB-101</a></li> <li><a href="/more/contact-us">Contact us</a></li> <li><a href="/more/how-to-cite">How to Cite</a></li> <li><a href="https://www.rcsb.org/pages/about-us/pdb-user-community">User Community</a></li> <li><a href="https://www.rcsb.org/pages/about-us/deia">Diversity, Equity, Inclusion, and Access</a></li> </ul> </li> </ul> </div> </div> </nav> <style> /* search section */ #search-button { padding: 8px 15px; border-top-left-radius: 0; border-bottom-left-radius: 0; } #query-input { width: 100%; border: 1px solid #ccc; padding: 8px; } #query-input:focus { outline: none; } #query-table { width: 100%; } #query-table td:first-child { width: 100%; } #autosuggest { position: relative; width: 100%; text-align: left; } #autosuggest-items { position: absolute; border: 1px solid #eee; border-bottom: none; border-top: none; z-index: 99; top: 100%; left: 0; right: 0; } #autosuggest-items div { padding: 10px; cursor: pointer; background-color: #fff; border-bottom: 1px solid #d4d4d4; } #autosuggest-items div:hover { background-color: #e9e9e9; } .autosuggest-active { background-color: DodgerBlue !important; color: #fff; } </style> <div id="print-header" class="row"> <div class="col-xs-6"> <div id="pdb101-logo"><a href="/"><img src="https://cdn.rcsb.org/pdb101/common/images/logo-pdb101.png" alt="RCSB PDB"></a></div> </div> <div id="rcsb-logo" class="col-xs-6 text-right">Training and outreach portal of <a href='http://www.rcsb.org' target='_blank'><img src='https://cdn.rcsb.org/pdb101/common/images/logo-rcsb.png' height='57'></a></div> </div> <div id="header" class="hidden-print"> <div class="container"> <div style="margin-top:10px;" class="row"> <div id="logo_container" class="col-sm-12 col-md-6 hidden-xs"> <div id="pdb101-logo"><a href="/"><img src="https://cdn.rcsb.org/pdb101/common/images/logo-pdb101.png" alt="RCSB PDB"></a></div> <p style="margin-top: 7px;"><em>Molecular explorations<br />through biology and medicine</em></p> </div> <div style="margin-bottom:10px;" class="col-sm-12 col-md-6 text-right"> <form id="searchForm" action="/search" method="post" onsubmit="return validateQueryInput();" autocomplete="off"> <input type="hidden" name="querySource" value="user"> <table id="query-table"> <tr> <td> <div id="autosuggest"> <input id="query-input" type="text" name="query" value="" placeholder="Search Molecule of the Month articles and more"> <div id="autosuggest-items"></div> </div> </td> <td><span id="search-button" onclick="doSearch();" class="btn btn-primary">Go</span></td> </tr> </table> </form> </div> </div>   <div class="row"> <div style="margin:5px 0px;" class="col-xs-6 col-sm-6 col-md-6"> <table> <tr> <td>Training and outreach portal of&nbsp</td> <td rowspan="2"><a href='http://www.rcsb.org' target='_blank'><img src='https://cdn.rcsb.org/pdb101/common/images/logo-rcsb.png' width='75'></a></td> </tr> </table> </div> <div class="hidden-xs col-sm-6 col-md-6 col-lg-6 col-xl-6 text-right">       <div class="social-media"><a target="_blank" href="/motm/rss.xml" data-original-title="Molecule of the Month RSS Feed" data-toggle="tooltip"><i class="fa fa-rss-square fa-lg"></i></a><a target="_blank" href="https://www.facebook.com/RCSBPDB" data-original-title="Facebook" data-toggle="tooltip"><i class="fa fa-facebook-square fa-lg"></i></a><a target="_blank" href="https://twitter.com/buildmodels" data-original-title="Twitter" data-toggle="tooltip"><i class="fa fa-twitter fa-lg"></i></a><a target="_blank" href="https://www.youtube.com/user/RCSBProteinDataBank" data-original-title="YouTube" data-toggle="tooltip"><i class="fa fa-youtube-play fa-lg"></i></a><a target="_blank" href="https://github.com/rcsb" data-original-title="Github" data-toggle="tooltip"><i class="fa fa-github fa-lg"></i></a><a target="_blank" href="https://www.linkedin.com/company/rcsb-protein-data-bank/" data-original-title="LinkedIn" data-toggle="tooltip"><i class="fa fa-linkedin fa-lg"></i></a></div> </div> <div id="socialMedaiMobile" class="col-xs-6 hidden-sm hidden-md hidden-lg hidden-xl text-right"> <div class="social-media"><a target="_blank" href="/motm/rss.xml" data-original-title="Molecule of the Month RSS Feed" data-toggle="tooltip"><i class="fa fa-rss-square fa-lg"></i></a><a target="_blank" href="https://www.facebook.com/RCSBPDB" data-original-title="Facebook" data-toggle="tooltip"><i class="fa fa-facebook-square fa-lg"></i></a><a target="_blank" href="https://twitter.com/buildmodels" data-original-title="Twitter" data-toggle="tooltip"><i class="fa fa-twitter fa-lg"></i></a><a target="_blank" href="https://www.youtube.com/user/RCSBProteinDataBank" data-original-title="YouTube" data-toggle="tooltip"><i class="fa fa-youtube-play fa-lg"></i></a><a target="_blank" href="https://www.linkedin.com/company/rcsb-protein-data-bank/" data-original-title="LinkedIn" data-toggle="tooltip"><i class="fa fa-linkedin fa-lg"></i></a></div> </div> </div> </div> </div> <div id="main_content" class="container"> <div class="row"> <div class="col-xs-12 col-sm-12 col-md-3"><style> div.pdb101-page-content { border-left:1px dotted #ddd; } div.page-content-left-half { border-left:1px dotted #ddd; } .pdb101-left-menu { margin-top: 20px; font-size: 16px; color:#337ac7; } .pdb101-left-menu-header { font-size: 16px; color: #333; background-color: #eee; border:1px solid #ddd; padding:10px 20px; border-top-left-radius:4px; border-top-right-radius:4px; } .pdb101-left-menu-item { border-bottom: 1px dashed #ccc; cursor: pointer; text-align:right; } .pdb101-left-menu-item:hover { background-color: #f8f8f8; } .pdb101-left-menu-item-text { display: inline-block; width: 85%; text-align: right; padding: 10px; } .pdb101-left-menu-item-chevron { display: inline-block; width: 10%; text-align: center; padding: 10px 0; vertical-align: top; margin-top:4px; font-size: 12px; } .fade { opacity: 0.25; } </style> <div class="pdb101-left-menu"> <div class="pdb101-left-menu-header"><a href="/sci-art/goodsell-gallery/">About</a></div> <div onclick="location.href="/sci-art/goodsell-gallery/kinetochore";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Kinetochore</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/influenza-virus";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Influenza Virus</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/bacteriophage-t4-infection";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Bacteriophage T4 Infection</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/jcvi-syn3a-minimal-cell";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">JCVI-syn3A Minimal Cell</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/hiv-infected-cell";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">HIV-Infected Cell</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/insulin-release";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Insulin Release</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/caulobacter-polar-microdomain";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Caulobacter Polar Microdomain</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/hiv-vaccine";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">HIV Vaccine</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/casein-micelle-and-fat-globule-in-milk";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Casein Micelle and Fat Globule in Milk</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/reca-and-dna";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">RecA and DNA</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/transfer-rna-and-gag-protein";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Transfer RNA and Gag Protein</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/cytoskeleton";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">CytoSkeleton</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/model-of-a-mycoplasma-cell";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Model of a Mycoplasma Cell</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/cellulose-synthase";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Cellulose Synthase</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/phage-based-covid-19-vaccine";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Phage-based COVID-19 Vaccine</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/myoglobin-in-a-whale-muscle-cell";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Myoglobin in a Whale Muscle Cell</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/escherichia-coli-bacterium";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Escherichia coli Bacterium</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/collagen-and-extracellular-matrix";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Collagen and Extracellular Matrix</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/red-blood-cell-cytoskeleton";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Red Blood Cell Cytoskeleton</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/myelin";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Myelin</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/immunological-synapse";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Immunological Synapse</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/coronavirus-life-cycle";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Coronavirus Life Cycle</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/sars-cov-2-fusion";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">SARS-CoV-2 Fusion</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/sars-cov-2-mrna-vaccine";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">SARS-CoV-2 mRNA Vaccine</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/coronavirus";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Coronavirus</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/respiratory-droplet";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Respiratory Droplet</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/sars-cov-2-and-neutralizing-antibodies";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">SARS-CoV-2 and Neutralizing Antibodies</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/influenza-vaccine";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Influenza Vaccine</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/measles-virus-proteins";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Measles Virus Proteins</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/poliovirus-neutralization";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Poliovirus Neutralization</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/lipid-droplets";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Lipid Droplets</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/excitatory-and-inhibitory-synapses";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Excitatory and Inhibitory Synapses</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/abiogenesis";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Abiogenesis</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/last-universal-common-ancestor";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Last Universal Common Ancestor</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/zika-virus";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Zika Virus</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/insulin-action";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Insulin Action</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/ebola-virus";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Ebola Virus</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/vascular-endothelial-growth-factor-vegf-signaling";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Vascular Endothelial Growth Factor (VegF) Signaling</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/chloroplast";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Chloroplast</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/autophagy";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Autophagy</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/mycoplasma-mycoides";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Mycoplasma mycoides</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/biosites-cytoplasm";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Biosites: Cytoplasm</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/biosites-blood-plasma";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Biosites: Blood Plasma</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/biosites-nucleus";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Biosites: Nucleus</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/biosites-red-blood-cell";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Biosites: Red Blood Cell</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/biosites-basement-membrane";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Biosites: Basement Membrane</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/biosites-muscle";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Biosites: Muscle</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/blood";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Blood</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/hiv-in-blood-plasma";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">HIV in Blood Plasma</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/sci-art/goodsell-gallery/escherichia-coli";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Escherichia coli</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> </div> </div> <div class="col-xs-12 col-sm-12 col-md-9"> <div data-elastic-include> <div class="row"> <div class="col-xs-8"> <h1>Molecular Landscapes by David S. Goodsell</h1> </div> </div> <h3>SARS-CoV-2 mRNA Vaccine, 2020</h3> <div class="img-with-caption"><a href="https://cdn.rcsb.org/pdb101/goodsell/png-800/sars-cov-2-mrna-vaccine.png" data-toggle="lightbox" data-title="SARS-CoV-2 mRNA Vaccine"><img src="https://cdn.rcsb.org/pdb101/goodsell/png-400/sars-cov-2-mrna-vaccine.png"></a><br><a href="https://cdn.rcsb.org/pdb101/goodsell/tif/sars-cov-2-mrna-vaccine.tif"><small>Download high quality TIFF image<span style="margin-left:5px" class="fa fa-cloud-download"></span></small></a></div> <p>Acknowledgement: Illustration by David S. Goodsell, RCSB Protein Data Bank; doi: 10.2210/rcsb_pdb/goodsell-gallery-027</p> <p>Messenger RNA (mRNA) vaccines developed for the COVID-19 pandemic are composed of long strands of RNA (magenta) that encode the SARS-CoV-2 spike surface glycoprotein enclosed in lipids (blue) that deliver the RNA into cells. Several different types of lipids are used, including familar lipids, cholesterol, ionizable lipids that interact with RNA, and lipids connected to polyethylene glycol chains (green) that help shield the vaccine from the immune system, lengthening its lifetime following administration. In this idealized illustration, all of the lipids are arranged in a simple circular bilayer that surrounds the mRNA and the PEG strands have both extended and folded conformations. In reality, the structure may be less regular, as suggested in the NanoLetters paper included below. Learn more about how this vaccine works in <a href="http://pdb101.rcsb.org/learn/resources-to-fight-the-covid-19-pandemic/sars-cov-2-mrna-vaccine">Resources to Fight the COVID-19 Pandemic.</a><br><br> <b>References</b><br> Corbett, K. S., et al. (2020) SARS-CoV-2 mRNA vaccine designs enable by prototype pathogen preparedness. Nature 586, 567-571. <br> Eygeris, Y., et al. (2020) Deconvoluting lipid nanoparticle structure for messenger RNA delivery. Nano Letters 20, 4543-4549.</p> </div> </div> </div> </div> <div id="footer_main" class="hidden-print"> <div class="container"> <div class="row"> <div class="col-sm-12 col-md-6"> <p><strong>About PDB-101</strong></p> <p>Researchers around the globe make 3D structures freely available from the Protein Data Bank (PDB) archive. PDB-101 training materials help graduate students, postdoctoral scholars, and researchers use PDB data and RCSB PDB tools. Outreach content demonstrate how PDB data impact fundamental biology, biomedicine, bioengineering/biotechnology, and energy sciences in 3D for a diverse and multidisciplinary user community. Education Materials provide lessons and activities for teaching and learning.</p> <p>PDB-101 is developed by the <a href="https://rcsb.org" target="_blank">RCSB PDB</a>.</p> </div> <div class="col-sm-12 col-md-6 text-center"> <p>RCSB PDB (<a href="http://nar.oxfordjournals.org/content/28/1/235.abstract" target="blank">citation</a>) is hosted by</p> <p><img src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/rad-sm.png" alt="Rutgers RAD logo.png" usemap="#rutgers-map" height="34" style="padding:0px 10px; border-right: 1px solid #666;"><img src="//cdn.rcsb.org/pdb101/common/images/Logo_UCSD-SDSC.png" alt="Logo_UCSD.png" usemap="#UCSD-SDSC-map" height="26" style="padding: 0px 10px; border-right: 1px solid #666;"><img src="//cdn.rcsb.org/pdb101/common/images/Logo_UCSF.png" alt="Logo_UCSF.png" usemap="#UCSF-map" height="26" style="padding-left: 10px;"><map name="rutgers-map"> <area shape="rect" coords="0,0,115,26" href="https://radcollaboratory.rutgers.edu/" alt="Rutgers-RAD" target="_blank"></map><map name="UCSD-SDSC-map"> <area shape="rect" coords="0,0,150,26" href="http://ucsd.edu/" alt="UCSD" target="_blank"> <area shape="rect" coords="151,0,255,26" href="http://www.sdsc.edu/" alt="SDSC" target="_blank"></map><map name="UCSF-map"> <area shape="rect" coords="0,0,64,26" href="http://www.ucsf.edu/" alt="UCSF" target="_blank"></map></p><br> <p>RCSB PDB is a member of </p> <p><span id='pdbmembers_footer'><a href='http://www.wwpdb.org/' target='_blank'><img src='//cdn.rcsb.org/pdb101/common/images/Logo_wwpdb.png' width='70'></a><span class='pipe'></span><a href='http://www.emdatabank.org/' target='_blank'><img src='https://cdn.rcsb.org/pdb101/common/images/EMDataResourcelogo.png' width='100'></a></p> </div> </div> </div> </div> <div id="footer_grant" class="hidden-print"> <div class="container"> <div class="row"> <p>RCSB PDB Core Operations are funded by the <a href="http://www.nsf.gov/" target="_blank">U.S. National Science Foundation</a> (DBI-2321666), the <a href="http://science.energy.gov/" target="_blank">US Department of Energy</a> (DE-SC0019749), and the <a href="http://www.cancer.gov/" target="_blank">National Cancer Institute</a>, <a href="http://www.niaid.nih.gov/" target="_blank">National Institute of Allergy and Infectious Diseases</a>, and <a href="http://www.nigms.nih.gov/" target="_blank">National Institute of General Medical Sciences</a> of the <a href="http://www.nih.gov/" target="_blank">National Institutes of Health</a> under grant R01GM157729.</p> </div> </div> </div> <div id="jira-fdbck"></div><script> //Google Analytics tracking code {/* (function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){ (i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o), m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m) })(window,document,'script','//www.google-analytics.com/analytics.js','ga'); ga('create', 'UA-71059016-1', 'auto'); ga('send', 'pageview'); */} </script> </div> </body> </html>

CINXE.COM

PDB-101: Goodsell Gallery: SARS-CoV-2 mRNA Vaccine