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Search results for: Baseline
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<form method="get" action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Baseline"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 990</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Baseline</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">990</span> Efficacy and Safety by Baseline A1c with Once-Weekly Dulaglutide in the AWARD Program</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alaa%20Mostafa">Alaa Mostafa</a>, <a href="https://publications.waset.org/abstracts/search?q=Samuel%20Dagogo-Jack"> Samuel Dagogo-Jack</a>, <a href="https://publications.waset.org/abstracts/search?q=Vivian%20Thieu"> Vivian Thieu</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Yu"> Maria Yu</a>, <a href="https://publications.waset.org/abstracts/search?q=Nan%20Zhang"> Nan Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Dara%20Schuster"> Dara Schuster</a>, <a href="https://publications.waset.org/abstracts/search?q=Luis-Emilio%20Garcia-Perez"> Luis-Emilio Garcia-Perez</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Dulaglutide (DU), a once-weekly glucagon-like peptide-1 receptor agonist, was studied in the AWARD clinical trial program in adult patients with type 2 diabetes (T2D) and demonstrated significant hemoglobin A1c (A1c) reduction and potential for weight loss. To evaluate the efficacy and safety of DU 1.5 mg and DU 0.75 mg in patients with T2D by baseline A1c <8.5% or ≥8.5%, a post-hoc analysis was conducted on AWARD-1 to -6 and -8 at 6 months. Across 7 studies, 55% to 82% of the DU-treated patients had a baseline A1c <8.5%, and 18% to 45% had a baseline A1c ≥8.5%. The ranges of A1c reductions with baseline A1c <8.5% and ≥8.5%, respectively, were: DU 1.5 mg: -0.67% to -1.25% and -1.22% to -2.37%; DU 0.75 mg: -0.53% to -1.07% and -1.37% to -2.19%. The A1c reduction from the pooled analysis was greater in patients with baseline A1c ≥8.5% than patients with baseline A1c <8.5%, respectively: DU 1.5 mg: -1.86% and -1.02%; DU 0.75 mg: -1.75% and -0.83%. DU treatments were well tolerated among baseline A1c subgroups. Across the AWARD program, DU 1.5 mg and DU 0.75 mg demonstrated significant A1c reduction in both subgroups with an acceptable safety profile. Compared to patients with baseline A1c <8.5%, patients with baseline A1c ≥8.5% had greater A1c reduction. Disclosures: This study was supported and conducted by Eli Lilly and Company, Indianapolis, IN, USA. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=A1c%20reduction" title="A1c reduction">A1c reduction</a>, <a href="https://publications.waset.org/abstracts/search?q=dulaglutide" title=" dulaglutide"> dulaglutide</a>, <a href="https://publications.waset.org/abstracts/search?q=type%202%20diabetes" title=" type 2 diabetes"> type 2 diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=weight%20loss" title=" weight loss"> weight loss</a> </p> <a href="https://publications.waset.org/abstracts/62989/efficacy-and-safety-by-baseline-a1c-with-once-weekly-dulaglutide-in-the-award-program" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/62989.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">395</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">989</span> Aerodynamic Investigation of Baseline-IV Bird-Inspired BWB Aircraft Design: Improvements over Baseline-III BWB </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=C.%20M.%20Nur%20Syazwani">C. M. Nur Syazwani</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20K.%20Ahmad%20Imran"> M. K. Ahmad Imran</a>, <a href="https://publications.waset.org/abstracts/search?q=Rizal%20E.%20M.%20Nasir"> Rizal E. M. Nasir</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The study on BWB UV begins in UiTM since 2005 and three designs have been studied and published. The latest designs are Baseline-III and inspired by birds that have features and aerodynamics behaviour of cruising birds without flapping capability. The aircraft featuring planform and configuration are similar to the bird. Baseline-III has major flaws particularly in its low lift-to-drag ratio, stability and issues regarding limited controllability. New design known as Baseline-IV replaces straight, swept wing to delta wing and have a broader tail compares to the Baseline-III’s. The objective of the study is to investigate aerodynamics of Baseline-IV bird-inspired BWB aircraft. This will be achieved by theoretical calculation and wind tunnel experiments. The result shows that both theoretical and wind tunnel experiments of Baseline-IV graph of CL and CD versus alpha are quite similar to each other in term of pattern of graph slopes and values. Baseline-IV has higher lift coefficient values at wide range of angle of attack compares to Baseline-III. Baseline-IV also has higher maximum lift coefficient, higher maximum lift-to-drag and lower parasite drag. It has stable pitch moment versus lift slope but negative moment at zero lift for zero angle-of-attack tail setting. At high angle of attack, Baseline-IV does not have stability reversal as shown in Baseline-III. Baseline-IV is proven to have improvements over Baseline-III in terms of lift, lift-to-drag ratio and pitch moment stability at high angle-of-attack. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=blended%20wing-body" title="blended wing-body">blended wing-body</a>, <a href="https://publications.waset.org/abstracts/search?q=bird-inspired%20blended%20wing-body" title=" bird-inspired blended wing-body"> bird-inspired blended wing-body</a>, <a href="https://publications.waset.org/abstracts/search?q=aerodynamic" title=" aerodynamic"> aerodynamic</a>, <a href="https://publications.waset.org/abstracts/search?q=stability" title=" stability"> stability</a> </p> <a href="https://publications.waset.org/abstracts/24050/aerodynamic-investigation-of-baseline-iv-bird-inspired-bwb-aircraft-design-improvements-over-baseline-iii-bwb" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24050.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">508</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">988</span> Evaluating the Baseline Chatacteristics of Static Balance in Young Adults</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=K.%20Abuzayan">K. Abuzayan</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20Alabed"> H. Alabed</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The objectives of this study (baseline study, n = 20) were to implement Matlab procedures for quantifying selected static balance variables, establish baseline data of selected variables which characterize static balance activities in a population of healthy young adult males, and to examine any trial effects on these variables. The results indicated that the implementation of Matlab procedures for quantifying selected static balance variables was practical and enabled baseline data to be established for selected variables. There was no significant trial effect. Recommendations were made for suitable tests to be used in later studies. Specifically it was found that one foot-tiptoes tests either in static balance is too challenging for most participants in normal circumstances. A one foot-flat eyes open test was considered to be representative and challenging for static balance. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=static%20balance" title="static balance">static balance</a>, <a href="https://publications.waset.org/abstracts/search?q=base%20of%20support" title=" base of support"> base of support</a>, <a href="https://publications.waset.org/abstracts/search?q=baseline%20data" title=" baseline data"> baseline data</a>, <a href="https://publications.waset.org/abstracts/search?q=young%20adults" title=" young adults"> young adults</a> </p> <a href="https://publications.waset.org/abstracts/10009/evaluating-the-baseline-chatacteristics-of-static-balance-in-young-adults" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/10009.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">521</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">987</span> Long-Baseline Single-epoch RTK Positioning Method Based on BDS-3 and Galileo Penta-Frequency Ionosphere-Reduced Combinations</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Liwei%20Liu">Liwei Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Shuguo%20Pan"> Shuguo Pan</a>, <a href="https://publications.waset.org/abstracts/search?q=Wang%20Gao"> Wang Gao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In order to take full advantages of the BDS-3 penta-frequency signals in the long-baseline RTK positioning, a long-baseline RTK positioning method based on the BDS-3 penta-frequency ionospheric-reduced (IR) combinations is proposed. First, the low noise and weak ionospheric delay characteristics of the multi-frequency combined observations of BDS-3is analyzed. Second, the multi-frequency extra-wide-lane (EWL)/ wide-lane (WL) combinations with long-wavelengths are constructed. Third, the fixed IR EWL combinations are used to constrain the IR WL, then constrain narrow-lane (NL)ambiguityies and start multi-epoch filtering. There is no need to consider the influence of ionospheric parameters in the third step. Compared with the estimated ionospheric model, the proposed method reduces the number of parameters by half, so it is suitable for the use of multi-frequency and multi-system real-time RTK. The results using real data show that the stepwise fixed model of the IR EWL/WL/NL combinations can realize long-baseline instantaneous cimeter-level positioning. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=penta-frequency" title="penta-frequency">penta-frequency</a>, <a href="https://publications.waset.org/abstracts/search?q=ionospheric-reduced%20%28IR%29" title=" ionospheric-reduced (IR)"> ionospheric-reduced (IR)</a>, <a href="https://publications.waset.org/abstracts/search?q=RTK%20positioning" title=" RTK positioning"> RTK positioning</a>, <a href="https://publications.waset.org/abstracts/search?q=long-baseline" title=" long-baseline"> long-baseline</a> </p> <a href="https://publications.waset.org/abstracts/145983/long-baseline-single-epoch-rtk-positioning-method-based-on-bds-3-and-galileo-penta-frequency-ionosphere-reduced-combinations" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/145983.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">169</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">986</span> Prognosis of Interstitial Lung Disease (ILD) Based on Baseline Pulmonary Function Test (PFT) Results in Omani Adult Patients Diagnosed with ILD In Sultan Qaboos University Hospital</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Manal%20Al%20Bahri">Manal Al Bahri</a>, <a href="https://publications.waset.org/abstracts/search?q=Saif%20Al%20Mubahisi"> Saif Al Mubahisi</a>, <a href="https://publications.waset.org/abstracts/search?q=Shamsa%20Al%20Shahaimi"> Shamsa Al Shahaimi</a>, <a href="https://publications.waset.org/abstracts/search?q=Asma%20Al%20Qasabi"> Asma Al Qasabi</a>, <a href="https://publications.waset.org/abstracts/search?q=Jamal%20Al%20Aghbari"> Jamal Al Aghbari</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: ILD is a common disease worldwide and in Oman. No previous Omani study was published regarding ILD prognosis based on baseline PFT results and other factors. This study aims to determine the severity of ILD by the baseline PFT, correlate between baseline PFT and outcome, and study other factors that influence disease mortality. Method: It is a retrospective cohort study; data was collected from January 2011 to December 2021 from electronic patient records (EPR). Means, Standard Deviations, frequencies, and Chi-square tests were used to examine the different variables in the study. Results: The total population of the study was 146 patients; 87 (59.6%) were females, and 59 (40.4%) were males. The median age was 59 years. Age at diagnosis, CVA, rheumatological disease, and baseline FVC were found to be statistically significant predictors of mortality .59.6% of the patients are diagnosed with IPF. Most of our study patients had mild disease based on baseline FVC. Death was higher with the more severe disease based on FVC. In mild disease (FVC >70%), 26.9% of the patients died. In moderate disease (FVC 50-69%),55.7% of the patients died, and in the severe group (FVC <50 %), 55.1% died. This was statistically significant with a P value of 0. 001. There is no statistically significant difference in the overall survival distribution between the different groups of DLCO. Conclusion: In our study, we found that ILD is more common among females, but death is more common among males. Based on baseline PFT, we can predict mortality by FVC level, as moderate to severe limitation is associated with a lower survival rate. DLCO was not a statistically significant parameter associated with mortality. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=PFT" title="PFT">PFT</a>, <a href="https://publications.waset.org/abstracts/search?q=ILD" title=" ILD"> ILD</a>, <a href="https://publications.waset.org/abstracts/search?q=FVC" title=" FVC"> FVC</a>, <a href="https://publications.waset.org/abstracts/search?q=DLCO" title=" DLCO"> DLCO</a>, <a href="https://publications.waset.org/abstracts/search?q=mortality" title=" mortality"> mortality</a> </p> <a href="https://publications.waset.org/abstracts/187425/prognosis-of-interstitial-lung-disease-ild-based-on-baseline-pulmonary-function-test-pft-results-in-omani-adult-patients-diagnosed-with-ild-in-sultan-qaboos-university-hospital" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/187425.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">32</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">985</span> Challenge of Baseline Hydrology Estimation at Large-Scale Watersheds</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Can%20Liu">Can Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Graham%20Markowitz"> Graham Markowitz</a>, <a href="https://publications.waset.org/abstracts/search?q=John%20Balay"> John Balay</a>, <a href="https://publications.waset.org/abstracts/search?q=Ben%20Pratt"> Ben Pratt</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Baseline or natural hydrology is commonly employed for hydrologic modeling and quantification of hydrologic alteration due to manmade activities. It can inform planning and policy related efforts for various state and federal water resource agencies to restore natural streamflow flow regimes. A common challenge faced by hydrologists is how to replicate unaltered streamflow conditions, particularly in large watershed settings prone to development and regulation. Three different methods were employed to estimate baseline streamflow conditions for 6 major subbasins the Susquehanna River Basin; those being: 1) incorporation of consumptive water use and reservoir operations back into regulated gaged records; 2) using a map correlation method and flow duration (exceedance probability) regression equations; 3) extending the pre-regulation streamflow records based on the relationship between concurrent streamflows at unregulated and regulated gage locations. Parallel analyses were perform among the three methods and limitations associated with each are presented. Results from these analyses indicate that generating baseline streamflow records at large-scale watersheds remain challenging, even with long-term continuous stream gage records available. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=baseline%20hydrology" title="baseline hydrology">baseline hydrology</a>, <a href="https://publications.waset.org/abstracts/search?q=streamflow%20gage" title=" streamflow gage"> streamflow gage</a>, <a href="https://publications.waset.org/abstracts/search?q=subbasin" title=" subbasin"> subbasin</a>, <a href="https://publications.waset.org/abstracts/search?q=regression" title=" regression"> regression</a> </p> <a href="https://publications.waset.org/abstracts/62920/challenge-of-baseline-hydrology-estimation-at-large-scale-watersheds" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/62920.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">324</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">984</span> Rumination Time and Reticuloruminal Temperature around Calving in Eutocic and Dystocic Dairy Cows</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Levente%20Kov%C3%A1cs">Levente Kovács</a>, <a href="https://publications.waset.org/abstracts/search?q=Fruzsina%20Luca%20K%C3%A9z%C3%A9r"> Fruzsina Luca Kézér</a>, <a href="https://publications.waset.org/abstracts/search?q=Ott%C3%B3%20Szenci"> Ottó Szenci</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Prediction of the onset of calving and recognizing difficulties at calving has great importance in decreasing neonatal losses and reducing the risk of health problems in the early postpartum period. In this study, changes of rumination time, reticuloruminal pH and temperature were investigated in eutocic (EUT, n = 10) and dystocic (DYS, n = 8) dairy cows around parturition. Rumination time was continuously recorded using an acoustic biotelemetry system, whereas reticuloruminal pH and temperature were recorded using an indwelling and wireless data transmitting system. The recording period lasted from 3 d before calving until 7 days in milk. For the comparison of rumination time and reticuloruminal characteristics between groups, time to return to baseline (the time interval required to return to baseline from the delivery of the calf) and area under the curve (AUC, both for prepartum and postpartum periods) were calculated for each parameter. Rumination time decreased from baseline 28 h before calving both for EUT and DYS cows (P = 0.023 and P = 0.017, respectively). After 20 h before calving, it decreased onwards to reach 32.4 ± 2.3 and 13.2 ± 2.0 min/4 h between 8 and 4 h before delivery in EUT and DYS cows, respectively, and then it decreased below 10 and 5 min during the last 4 h before calving (P = 0.003 and P = 0.008, respectively). Until 12 h after delivery rumination time reached 42.6 ± 2.7 and 51.0 ± 3.1 min/4 h in DYS and EUT dams, respectively, however, AUC and time to return to baseline suggested lower rumination activity in DYS cows than in EUT dams for the 168-h postpartum observational period (P = 0.012 and P = 0.002, respectively). Reticuloruminal pH decreased from baseline 56 h before calving both for EUT and DYS cows (P = 0.012 and P = 0.016, respectively), but did not differ between groups before delivery. In DYS cows, reticuloruminal temperature decreased from baseline 32 h before calving by 0.23 ± 0.02 °C (P = 0.012), whereas in EUT cows such a decrease was found only 20 h before delivery (0.48 ± 0.05 °C, P < 0.01). AUC of reticuloruminal temperature calculated for the prepartum period was greater in EUT cows than in DYS cows (P = 0.042). During the first 4 h after calving, it decreased from 39.7 ± 0.1 to 39.00 ± 0.1 °C and from 39.8 ± 0.1 to 38.8 ± 0.1 °C in EUT and DYS cows, respectively (P < 0.01 for both groups) and reached baseline levels after 35.4 ± 3.4 and 37.8 ± 4.2 h after calving in EUT and DYS cows, respectively. Based on our results, continuous monitoring of changes in rumination time and reticuloruminal temperature seems to be promising in the early detection of cows with a higher risk of dystocia. Depressed postpartum rumination time of DYS cows highlights the importance of the monitoring of cows experiencing difficulties at calving. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=reticuloruminal%20pH" title="reticuloruminal pH">reticuloruminal pH</a>, <a href="https://publications.waset.org/abstracts/search?q=reticuloruminal%20temperature" title=" reticuloruminal temperature"> reticuloruminal temperature</a>, <a href="https://publications.waset.org/abstracts/search?q=rumination%20time" title=" rumination time"> rumination time</a>, <a href="https://publications.waset.org/abstracts/search?q=dairy%20cows" title=" dairy cows"> dairy cows</a>, <a href="https://publications.waset.org/abstracts/search?q=dystocia" title=" dystocia"> dystocia</a> </p> <a href="https://publications.waset.org/abstracts/61949/rumination-time-and-reticuloruminal-temperature-around-calving-in-eutocic-and-dystocic-dairy-cows" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/61949.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">316</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">983</span> The Effect of Acute Rejection and Delayed Graft Function on Renal Transplant Fibrosis in Live Donor Renal Transplantation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Wisam%20Ismail">Wisam Ismail</a>, <a href="https://publications.waset.org/abstracts/search?q=Sarah%20Hosgood"> Sarah Hosgood</a>, <a href="https://publications.waset.org/abstracts/search?q=Michael%20Nicholson"> Michael Nicholson</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The research hypothesis is that early post-transplant allograft fibrosis will be linked to donor factors and that acute rejection and/or delayed graft function in the recipient will be independent risk factors for the development of fibrosis. This research hypothesis is to explore whether acute rejection/delay graft function has an effect on the renal transplant fibrosis within the first year post live donor kidney transplant between 1998 and 2009. Methods: The study has been designed to identify five time points of the renal transplant biopsies [0 (pre-transplant), 1 month, 3 months, 6 months and 12 months] for 300 live donor renal transplant patients over 12 years period between March 1997 – August 2009. Paraffin fixed slides were collected from Leicester General Hospital and Leicester Royal Infirmary. These were routinely sectioned at a thickness of 4 Micro millimetres for standardization. Conclusions: Fibrosis at 1 month after the transplant was found significantly associated with baseline fibrosis (p<0.001) and HTN in the transplant recipient (p<0.001). Dialysis after the transplant showed a weak association with fibrosis at 1 month (p=0.07). The negative coefficient for HTN (-0.05) suggests a reduction in fibrosis in the absence of HTN. Fibrosis at 1 month was significantly associated with fibrosis at baseline (p 0.01 and 95%CI 0.11 to 0.67). Fibrosis at 3, 6 or 12 months was not found to be associated with fibrosis at baseline (p=0.70. 0.65 and 0.50 respectively). The amount of fibrosis at 1 month is significantly associated with graft survival (p=0.01 and 95%CI 0.02 to 0.14). Rejection and severity of rejection were not found to be associated with fibrosis at 1 month. The amount of fibrosis at 1 month was significantly associated with graft survival (p=0.02) after adjusting for baseline fibrosis (p=0.01). Both baseline fibrosis and graft survival were significant predictive factors. The amount of fibrosis at 1 month was not found to be significantly associated with rejection (p=0.64) after adjusting for baseline fibrosis (p=0.01). The amount of fibrosis at 1 month was not found to be significantly associated with rejection severity (p=0.29) after adjusting for baseline fibrosis (p=0.04). Fibrosis at baseline and HTN in the recipient were found to be predictive factors of fibrosis at 1 month. (p 0.02, p <0.001 respectively). Age of the donor, their relation to the patient, the pre-op Creatinine, artery, kidney weight and warm time were not found to be significantly associated with fibrosis at 1 month. In this complex model baseline fibrosis, HTN in the recipient and cold time were found to be predictive factors of fibrosis at 1 month (p=0.01,<0.001 and 0.03 respectively). Donor age was found to be a predictive factor of fibrosis at 6 months. The above analysis was repeated for 3, 6 and 12 months. No associations were detected between fibrosis and any of the explanatory variables with the exception of the donor age which was found to be a predictive factor of fibrosis at 6 months. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fibrosis" title="fibrosis">fibrosis</a>, <a href="https://publications.waset.org/abstracts/search?q=transplant" title=" transplant"> transplant</a>, <a href="https://publications.waset.org/abstracts/search?q=renal" title=" renal"> renal</a>, <a href="https://publications.waset.org/abstracts/search?q=rejection" title=" rejection"> rejection</a> </p> <a href="https://publications.waset.org/abstracts/69477/the-effect-of-acute-rejection-and-delayed-graft-function-on-renal-transplant-fibrosis-in-live-donor-renal-transplantation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/69477.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">230</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">982</span> Machine Learning Based Approach for Measuring Promotion Effectiveness in Multiple Parallel Promotions’ Scenarios</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Revoti%20Prasad%20Bora">Revoti Prasad Bora</a>, <a href="https://publications.waset.org/abstracts/search?q=Nikita%20Katyal"> Nikita Katyal </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Promotion is a key element in the retail business. Thus, analysis of promotions to quantify their effectiveness in terms of Revenue and/or Margin is an essential activity in the retail industry. However, measuring the sales/revenue uplift is based on estimations, as the actual sales/revenue without the promotion is not present. Further, the presence of Halo and Cannibalization in a multiple parallel promotions’ scenario complicates the problem. Calculating Baseline by considering inter-brand/competitor items or using Halo and Cannibalization's impact on Revenue calculations by considering Baseline as an interpretation of items’ unit sales in neighboring nonpromotional weeks individually may not capture the overall Revenue uplift in the case of multiple parallel promotions. Hence, this paper proposes a Machine Learning based method for calculating the Revenue uplift by considering the Halo and Cannibalization impact on the Baseline and the Revenue. In the first section of the proposed methodology, Baseline of an item is calculated by incorporating the impact of the promotions on its related items. In the later section, the Revenue of an item is calculated by considering both Halo and Cannibalization impacts. Hence, this methodology enables correct calculation of the overall Revenue uplift due a given promotion. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Halo" title="Halo">Halo</a>, <a href="https://publications.waset.org/abstracts/search?q=Cannibalization" title=" Cannibalization"> Cannibalization</a>, <a href="https://publications.waset.org/abstracts/search?q=promotion" title=" promotion"> promotion</a>, <a href="https://publications.waset.org/abstracts/search?q=Baseline" title=" Baseline"> Baseline</a>, <a href="https://publications.waset.org/abstracts/search?q=temporary%20price%20reduction" title=" temporary price reduction"> temporary price reduction</a>, <a href="https://publications.waset.org/abstracts/search?q=retail" title=" retail"> retail</a>, <a href="https://publications.waset.org/abstracts/search?q=elasticity" title=" elasticity"> elasticity</a>, <a href="https://publications.waset.org/abstracts/search?q=cross%20price%20elasticity" title=" cross price elasticity"> cross price elasticity</a>, <a href="https://publications.waset.org/abstracts/search?q=machine%20learning" title=" machine learning"> machine learning</a>, <a href="https://publications.waset.org/abstracts/search?q=random%20forest" title=" random forest"> random forest</a>, <a href="https://publications.waset.org/abstracts/search?q=linear%20regression" title=" linear regression "> linear regression </a> </p> <a href="https://publications.waset.org/abstracts/134852/machine-learning-based-approach-for-measuring-promotion-effectiveness-in-multiple-parallel-promotions-scenarios" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/134852.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">177</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">981</span> Efficacy of the ExVent Accessory with the O2Vent Optima Oral Appliance in the Treatment of Obstructive Sleep Apnea: A Clinical Trial</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sat%20Sharma">Sat Sharma</a>, <a href="https://publications.waset.org/abstracts/search?q=Antonella%20Conflitti"> Antonella Conflitti</a>, <a href="https://publications.waset.org/abstracts/search?q=Hilary%20Reiter"> Hilary Reiter</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: The study's purpose was to assess the efficacy of the oral appliance device O2Vent Optima + ExVent as compared to Optima in the treatment of OSA. Methods: A prospective, open-label study conducted at 3 sites included subjects with mild to moderate OSA (AHI ≥ 5 and ≤ 30). Screening Phase: A diagnostic in-lab PSG study was performed to confirm a diagnosis of mild to moderate OSA. Treatment I: Subjects used O2Vent Optima for 6 weeks and underwent an in-lab PSG sleep night while using the O2Vent Optima. Treatment II: Subjects used O2Vent Optima + ExVent for 6 weeks and underwent an in-lab PSG sleep night while using the O2Vent Optima + ExVent Primary Effectiveness Measure: Change in AHI between baseline vs. O2Vent Optima MAD vs. O2Vent Optima + ExVent. Results: Treatment with Optima, Optima + ExVent reduced AHI from 22.5±6.4/hr to 12.6±4.5/hr to 5.9±2.7 (p< 0.005 baseline vs. Optima and Optima + ExVent; p<0.05 Optima MAD vs. Optima + ExVent). The average reduction in AHI with Optima was 43%, and with Optima + ExVent was 72%. The lowest oxygen during sleep increased from 84.6±2.7% to 88.6±2.9% to 91.6±3.2% (p< 0.005 baseline vs. Optima and Optima + ExVent; p<0.05 Optima vs. Optima + ExVent). During the trial, patients on treatment with Optima and Optima + ExVent demonstrated no excessive adverse events or device malfunction. Conclusion: Treatment with O2Vent Optima and O2Vent Optima + ExVent significantly improved OSA compared to the baseline. An even greater benefit was observed with the addition of ExVent to the Optima in mild to moderate OSA. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=oral%20appliance" title="oral appliance">oral appliance</a>, <a href="https://publications.waset.org/abstracts/search?q=O2Vent" title=" O2Vent"> O2Vent</a>, <a href="https://publications.waset.org/abstracts/search?q=sleep%20dentistry" title=" sleep dentistry"> sleep dentistry</a>, <a href="https://publications.waset.org/abstracts/search?q=sleep%20apnea" title=" sleep apnea"> sleep apnea</a> </p> <a href="https://publications.waset.org/abstracts/167754/efficacy-of-the-exvent-accessory-with-the-o2vent-optima-oral-appliance-in-the-treatment-of-obstructive-sleep-apnea-a-clinical-trial" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/167754.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">64</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">980</span> Optical Variability of Faint Quasars</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kassa%20Endalamaw%20Rewnu">Kassa Endalamaw Rewnu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The variability properties of a quasar sample, spectroscopically complete to magnitude J = 22.0, are investigated on a time baseline of 2 years using three different photometric bands (U, J and F). The original sample was obtained using a combination of different selection criteria: colors, slitless spectroscopy and variability, based on a time baseline of 1 yr. The main goals of this work are two-fold: first, to derive the percentage of variable quasars on a relatively short time baseline; secondly, to search for new quasar candidates missed by the other selection criteria; and, thus, to estimate the completeness of the spectroscopic sample. In order to achieve these goals, we have extracted all the candidate variable objects from a sample of about 1800 stellar or quasi-stellar objects with limiting magnitude J = 22.50 over an area of about 0.50 deg2. We find that > 65% of all the objects selected as possible variables are either confirmed quasars or quasar candidates on the basis of their colors. This percentage increases even further if we exclude from our lists of variable candidates a number of objects equal to that expected on the basis of `contamination' induced by our photometric errors. The percentage of variable quasars in the spectroscopic sample is also high, reaching about 50%. On the basis of these results, we can estimate that the incompleteness of the original spectroscopic sample is < 12%. We conclude that variability analysis of data with small photometric errors can be successfully used as an efficient and independent (or at least auxiliary) selection method in quasar surveys, even when the time baseline is relatively short. Finally, when corrected for the different intrinsic time lags corresponding to a fixed observed time baseline, our data do not show a statistically significant correlation between variability and either absolute luminosity or redshift. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nuclear%20activity" title="nuclear activity">nuclear activity</a>, <a href="https://publications.waset.org/abstracts/search?q=galaxies" title=" galaxies"> galaxies</a>, <a href="https://publications.waset.org/abstracts/search?q=active%20quasars" title=" active quasars"> active quasars</a>, <a href="https://publications.waset.org/abstracts/search?q=variability" title=" variability"> variability</a> </p> <a href="https://publications.waset.org/abstracts/166872/optical-variability-of-faint-quasars" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/166872.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">82</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">979</span> A Short-Baseline Dual-Antenna BDS/MEMS-IMU Integrated Navigation System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tijing%20Cai">Tijing Cai</a>, <a href="https://publications.waset.org/abstracts/search?q=Qimeng%20Xu"> Qimeng Xu</a>, <a href="https://publications.waset.org/abstracts/search?q=Daijin%20Zhou"> Daijin Zhou</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper puts forward a short-baseline dual-antenna BDS/MEMS-IMU integrated navigation, constructs the carrier phase double difference model of BDS (BeiDou Navigation Satellite System), and presents a 2-position initial orientation method on BDS. The Extended Kalman-filter has been introduced for the integrated navigation system. The differences between MEMS-IMU and BDS position, velocity and carrier phase indications are used as measurements. To show the performance of the short-baseline dual-antenna BDS/MEMS-IMU integrated navigation system, the experiment results show that the position error is less than 1m, the pitch angle error and roll angle error are less than 0.1°, and the heading angle error is about 1°. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=MEMS-IMU%20%28Micro-Electro-Mechanical%20System%20Inertial%20Measurement%20Unit%29" title="MEMS-IMU (Micro-Electro-Mechanical System Inertial Measurement Unit)">MEMS-IMU (Micro-Electro-Mechanical System Inertial Measurement Unit)</a>, <a href="https://publications.waset.org/abstracts/search?q=BDS%20%28BeiDou%20Navigation%20Satellite%20System%29" title=" BDS (BeiDou Navigation Satellite System)"> BDS (BeiDou Navigation Satellite System)</a>, <a href="https://publications.waset.org/abstracts/search?q=dual-antenna" title=" dual-antenna"> dual-antenna</a>, <a href="https://publications.waset.org/abstracts/search?q=integrated%20navigation" title=" integrated navigation"> integrated navigation</a> </p> <a href="https://publications.waset.org/abstracts/97626/a-short-baseline-dual-antenna-bdsmems-imu-integrated-navigation-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/97626.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">193</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">978</span> Opportunities of Clean Development Mechanism through Hydropower in Nepal</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Usha%20Khatiwada">Usha Khatiwada</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nepal’s overall energy baseline: It has been proposed that hydropower projects for domestic consumption can earn CDM revenue in Nepal if a new methodology is established that takes into account not only consumption in Nepal of grid electricity but also other fuels such as kerosene, diesel, and firewood, used by a vast majority of the population for their lighting and other needs. However, this would mean that we would be trying to combine grid electricity supply and consumers not supplied from the grid into one methodology. Such a sweeping baseline may have a very small chance of success with the CDM Executive Board. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=environment" title="environment">environment</a>, <a href="https://publications.waset.org/abstracts/search?q=clean%20development%20mechanism" title=" clean development mechanism"> clean development mechanism</a>, <a href="https://publications.waset.org/abstracts/search?q=hydropower" title=" hydropower"> hydropower</a>, <a href="https://publications.waset.org/abstracts/search?q=Nepal" title=" Nepal"> Nepal</a> </p> <a href="https://publications.waset.org/abstracts/9039/opportunities-of-clean-development-mechanism-through-hydropower-in-nepal" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9039.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">403</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">977</span> Prediction of Super-Response to Cardiac Resynchronisation Therapy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vadim%20A.%20Kuznetsov">Vadim A. Kuznetsov</a>, <a href="https://publications.waset.org/abstracts/search?q=Anna%20M.%20Soldatova"> Anna M. Soldatova</a>, <a href="https://publications.waset.org/abstracts/search?q=Tatyana%20N.%20Enina"> Tatyana N. Enina</a>, <a href="https://publications.waset.org/abstracts/search?q=Elena%20A.%20Gorbatenko"> Elena A. Gorbatenko</a>, <a href="https://publications.waset.org/abstracts/search?q=Dmitrii%20V.%20Krinochkin"> Dmitrii V. Krinochkin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of the study was to evaluate potential parameters related with super-response to CRT. Methods: 60 CRT patients (mean age 54.3 ± 9.8 years; 80% men) with congestive heart failure (CHF) II-IV NYHA functional class, left ventricular ejection fraction < 35% were enrolled. At baseline, 1 month, 3 months and each 6 months after implantation clinical, electrocardiographic and echocardiographic parameters, NT-proBNP level were evaluated. According to the best decrease of left ventricular end-systolic volume (LVESV) (mean follow-up period 33.7 ± 15.1 months) patients were classified as super-responders (SR) (n=28; reduction in LVESV ≥ 30%) and non-SR (n=32; reduction in LVESV < 30%). Results: At baseline groups differed in age (58.1 ± 5.8 years in SR vs 50.8 ± 11.4 years in non-SR; p=0.003), gender (female gender 32.1% vs 9.4% respectively; p=0.028), width of QRS complex (157.6 ± 40.6 ms in SR vs 137.6 ± 33.9 ms in non-SR; p=0.044). Percentage of LBBB was equal between groups (75% in SR vs 59.4% in non-SR; p=0.274). All parameters of mechanical dyssynchrony were higher in SR, but only difference in left ventricular pre-ejection period (LVPEP) was statistically significant (153.0 ± 35.9 ms vs. 129.3 ± 28.7 ms p=0.032). NT-proBNP level was lower in SR (1581 ± 1369 pg/ml vs 3024 ± 2431 pg/ml; p=0.006). The survival rates were 100% in SR and 90.6% in non-SR (log-rank test P=0.002). Multiple logistic regression analysis showed that LVPEP (HR 1.024; 95% CI 1.004–1.044; P = 0.017), baseline NT-proBNP level (HR 0.628; 95% CI 0.414–0.953; P=0.029) and age at baseline (HR 1.094; 95% CI 1.009-1.168; P=0.30) were independent predictors for CRT super-response. ROC curve analysis demonstrated sensitivity 71.9% and specificity 82.1% (AUC=0.827; p < 0.001) of this model in prediction of super-response to CRT. Conclusion: Super-response to CRT is associated with better survival in long-term period. Presence of LBBB was not associated with super-response. LVPEP, NT-proBNP level, and age at baseline can be used as independent predictors of CRT super-response. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cardiac%20resynchronisation%20therapy" title="cardiac resynchronisation therapy">cardiac resynchronisation therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=superresponse" title=" superresponse"> superresponse</a>, <a href="https://publications.waset.org/abstracts/search?q=congestive%20heart%20failure" title=" congestive heart failure"> congestive heart failure</a>, <a href="https://publications.waset.org/abstracts/search?q=left%20bundle%20branch%20block" title=" left bundle branch block"> left bundle branch block</a> </p> <a href="https://publications.waset.org/abstracts/80501/prediction-of-super-response-to-cardiac-resynchronisation-therapy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/80501.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">399</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">976</span> A Discrete Logit Survival Model with a Smooth Baseline Hazard for Age at First Alcohol Intake among Students at Tertiary Institutions in Thohoyandou, South Africa</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20Bere">A. Bere</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20G.%20Sithuba"> H. G. Sithuba</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20Kyei"> K. Kyei</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Sigauke"> C. Sigauke</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We employ a discrete logit survival model to investigate the risk factors for early alcohol intake among students at two tertiary institutions in Thohoyandou, South Africa. Data were collected from a sample of 744 students using a self-administered questionnaire. Significant covariates were arrived at through a regularization algorithm implemented using the glmmLasso package. The tuning parameter was determined using a five-fold cross-validation algorithm. The baseline hazard was modelled as a smooth function of time through the use of spline functions. The results show that the hazard of initial alcohol intake peaks at the age of about 16 years and that at any given time, being of a male gender, prior use of other drugs, having drinking peers, having experienced negative life events and physical abuse are associated with a higher risk of alcohol intake debut. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cross-validation" title="cross-validation">cross-validation</a>, <a href="https://publications.waset.org/abstracts/search?q=discrete%20hazard%20model" title=" discrete hazard model"> discrete hazard model</a>, <a href="https://publications.waset.org/abstracts/search?q=LASSO" title=" LASSO"> LASSO</a>, <a href="https://publications.waset.org/abstracts/search?q=smooth%20baseline%20hazard" title=" smooth baseline hazard"> smooth baseline hazard</a> </p> <a href="https://publications.waset.org/abstracts/92744/a-discrete-logit-survival-model-with-a-smooth-baseline-hazard-for-age-at-first-alcohol-intake-among-students-at-tertiary-institutions-in-thohoyandou-south-africa" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/92744.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">192</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">975</span> Poliovirus Vaccine Immunity among Chronically Malnourished Pakistani Infants: A Randomized Controlled Trial from Developing Country</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ali%20Faisal%20Saleem">Ali Faisal Saleem</a>, <a href="https://publications.waset.org/abstracts/search?q=Farheen%20Quadri"> Farheen Quadri</a>, <a href="https://publications.waset.org/abstracts/search?q=Mach%20Ondrej"> Mach Ondrej</a>, <a href="https://publications.waset.org/abstracts/search?q=Anita%20Zaidi"> Anita Zaidi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Purpose: Pakistan is the final frontier for a polio-free world. Chronic malnutrition is associated with lack of effective gut immunity, and possibly associated with poliomyelitis in children received multiple OPV. We evaluate IPV dose administered together with OPV results in higher immunogenicity and mucosal immunity compared to OPV alone in chronically malnourished infants. Methods AND Materials: A community-based, unblinded-randomized-trial, conducted in 5 peri-urban, low-middle-income households of Karachi, in infants 9-12 months. Two study groups were non-malnourished (HAZ= -2 or more) and chronic malnourished (HAZ <-2SD), with 2-arms each i) OPV and ii) OPV and IPV. Two blood specimens (2ml) at baseline and at day 28 and two stool specimens (6 gm.) at day 29 and after 7 days. All infants received a bOPV challenge dose after first stool specimen. Calculates sample size was 210 in each arm. Serological (baseline compared to 28 days post-vaccine) and mucosal immunity after one week of bOPV challenge dose were study outcomes. Results: Baseline seroprevalence in malnourished infants were low compared to non-malnourished (P1, P2 and P3 (p=<0.001). There is significant rise in antibody titer and P1 seroprevalence in Mal A and B after receiving study vaccine; much higher in Mal B. Infants randomized to bOPV + IPV study vaccine showed incremental immune response against P1 (Mal B, 92.2%; Nor B, 98.4%), P2 (Mal B, 90.4%; Nor B, 94.7%), and P3 (Mal B, 85.6% and Nor B, 93.5%) was observed. A significant proportion of infants in malnourished (P1, 13%; P2, 24%; P3, 26%) and normally nourished group (P1, 5%; P2, 11%; P3, 14%) were found to be seronegative at baseline. Infants who received BOPV + IPV as their study vaccine showed a very high seroconversion response after vaccine (p=<0.001 for P1, P2 and P3). Majority of the specimens were negative at baseline (Mal A, 2%, Mal B, 1%; Nor A, 2%; Nor B, 1%), and remains negative after bOPV challenge dose (Mal A, 8%, Mal B, 6%; Nor A, 11%; Nor B, 10%). Conclusion: Malnourished-infants have low poliovirus-seroprevalence that increased remarkably after IPV. There is less viral shedding after IPV in infants. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chronic%20malnutrition" title="chronic malnutrition">chronic malnutrition</a>, <a href="https://publications.waset.org/abstracts/search?q=infants" title=" infants"> infants</a>, <a href="https://publications.waset.org/abstracts/search?q=IPV" title=" IPV"> IPV</a>, <a href="https://publications.waset.org/abstracts/search?q=OPV" title=" OPV"> OPV</a> </p> <a href="https://publications.waset.org/abstracts/14057/poliovirus-vaccine-immunity-among-chronically-malnourished-pakistani-infants-a-randomized-controlled-trial-from-developing-country" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/14057.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">398</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">974</span> A Novel NRIS Index to Evaluate Brain Activity in Prefrontal Regions While Listening to First and Second Languages for Long Time Periods</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kensho%20Takahashi">Kensho Takahashi</a>, <a href="https://publications.waset.org/abstracts/search?q=Ko%20Watanabe"> Ko Watanabe</a>, <a href="https://publications.waset.org/abstracts/search?q=Takashi%20Kaburagi"> Takashi Kaburagi</a>, <a href="https://publications.waset.org/abstracts/search?q=Hiroshi%20Tanaka"> Hiroshi Tanaka</a>, <a href="https://publications.waset.org/abstracts/search?q=Kajiro%20Watanabe"> Kajiro Watanabe</a>, <a href="https://publications.waset.org/abstracts/search?q=Yosuke%20Kurihara"> Yosuke Kurihara </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Near-infrared spectroscopy (NIRS) has been widely used as a non-invasive method to measure brain activity, but it is corrupted by baseline drift noise. Here we present a method to measure regional cerebral blood flow as a derivative of NIRS output. We investigate whether, when listening to languages, blood flow can reasonably localize and represent regional brain activity or not. The prefrontal blood flow distribution pattern when advanced second-language listeners listened to a second language (L2) was most similar to that when listening to their first language (L1) among the patterns of mean and standard deviation. In experiments with 25 healthy subjects, the maximum blood flow was localized to the left BA46 of advanced listeners. The blood flow presented is robust to baseline drift and stably localizes regional brain activity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=NIRS" title="NIRS">NIRS</a>, <a href="https://publications.waset.org/abstracts/search?q=oxy-hemoglobin" title=" oxy-hemoglobin"> oxy-hemoglobin</a>, <a href="https://publications.waset.org/abstracts/search?q=baseline%20drift" title=" baseline drift"> baseline drift</a>, <a href="https://publications.waset.org/abstracts/search?q=blood%20flow" title=" blood flow"> blood flow</a>, <a href="https://publications.waset.org/abstracts/search?q=working%20memory" title=" working memory"> working memory</a>, <a href="https://publications.waset.org/abstracts/search?q=BA46" title=" BA46"> BA46</a>, <a href="https://publications.waset.org/abstracts/search?q=first%20language" title=" first language"> first language</a>, <a href="https://publications.waset.org/abstracts/search?q=second%20language" title=" second language"> second language</a> </p> <a href="https://publications.waset.org/abstracts/22459/a-novel-nris-index-to-evaluate-brain-activity-in-prefrontal-regions-while-listening-to-first-and-second-languages-for-long-time-periods" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/22459.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">559</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">973</span> Thermal Property Improvement of Silica Reinforced Epoxy Composite Specimens</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hyu%20Sang%20Jo">Hyu Sang Jo</a>, <a href="https://publications.waset.org/abstracts/search?q=Gyo%20Woo%20Lee"> Gyo Woo Lee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, the mechanical and thermal properties of epoxy composites that are reinforced with micrometer-sized silica particles were investigated by using the specimen experiments. For all specimens used in this study (from the baseline to specimen containing 70 wt% silica filler), the tensile strengths were gradually increased by 8-10%, but the ductility of the specimen was decreased by 34%, compared with those of the baseline samples. Similarly, for the samples containing 70 wt% silica filler, the coefficient of thermal expansion was reduced by 25%, but the thermal conductivity was increased by 100%, compared with those of the baseline samples. The improvement of thermal stability of the silica-reinforced specimen was confirmed to be within the experimented range, and the smaller silica particle was found to be more effective in delaying the thermal expansion of the specimens. When the smaller particle was used as filler, due to the increased specific interface area between filler and matrix, the thermal conductivities of the composite specimens were measured to be slightly lower than those of the specimens reinforced with the larger particle. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=carbon%20nanotube%20filler" title="carbon nanotube filler">carbon nanotube filler</a>, <a href="https://publications.waset.org/abstracts/search?q=epoxy%20composite" title=" epoxy composite"> epoxy composite</a>, <a href="https://publications.waset.org/abstracts/search?q=mechanical%20property" title=" mechanical property"> mechanical property</a>, <a href="https://publications.waset.org/abstracts/search?q=thermal%20property" title=" thermal property"> thermal property</a> </p> <a href="https://publications.waset.org/abstracts/44711/thermal-property-improvement-of-silica-reinforced-epoxy-composite-specimens" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/44711.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">236</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">972</span> Improvement of the Aerodynamic Behaviour of a Land Rover Discovery 4 in Turbulent Flow Using Computational Fluid Dynamics (CFD)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20Al-Saadi">Ahmed Al-Saadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Hassanpour"> Ali Hassanpour</a>, <a href="https://publications.waset.org/abstracts/search?q=Tariq%20Mahmud"> Tariq Mahmud</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The main objective of this study is to investigate ways to reduce the aerodynamic drag coefficient and to increase the stability of the full-size Sport Utility Vehicle using three-dimensional Computational Fluid Dynamics (CFD) simulation. The baseline model in the simulation was the Land Rover Discovery 4. Many aerodynamic devices and external design modifications were used in this study. These reduction aerodynamic techniques were tested individually or in combination to get the best design. All new models have the same capacity and comfort of the baseline model. Uniform freestream velocity of the air at inlet ranging from 28 m/s to 40 m/s was used. ANSYS Fluent software (version 16.0) was used to simulate all models. The drag coefficient obtained from the ANSYS Fluent for the baseline model was validated with experimental data. It is found that the use of modern aerodynamic add-on devices and modifications has a significant effect in reducing the aerodynamic drag coefficient. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aerodynamics" title="aerodynamics">aerodynamics</a>, <a href="https://publications.waset.org/abstracts/search?q=RANS" title=" RANS"> RANS</a>, <a href="https://publications.waset.org/abstracts/search?q=sport%20utility%20vehicle" title=" sport utility vehicle"> sport utility vehicle</a>, <a href="https://publications.waset.org/abstracts/search?q=turbulent%20flow" title=" turbulent flow"> turbulent flow</a> </p> <a href="https://publications.waset.org/abstracts/63731/improvement-of-the-aerodynamic-behaviour-of-a-land-rover-discovery-4-in-turbulent-flow-using-computational-fluid-dynamics-cfd" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/63731.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">316</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">971</span> Effect of Kinesio Taping on Anaerobic Power and Maximum Oxygen Consumption after Eccentric Exercise</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Disaphon%20Boobpachat">Disaphon Boobpachat</a>, <a href="https://publications.waset.org/abstracts/search?q=Nuttaset%20Manimmanakorn"> Nuttaset Manimmanakorn</a>, <a href="https://publications.waset.org/abstracts/search?q=Apiwan%20Manimmanakorn"> Apiwan Manimmanakorn</a>, <a href="https://publications.waset.org/abstracts/search?q=Worrawut%20Thuwakum"> Worrawut Thuwakum</a>, <a href="https://publications.waset.org/abstracts/search?q=Michael%20J.%20Hamlin"> Michael J. Hamlin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objectives: To evaluate effect of kinesio tape compared to placebo tape and static stretching on recovery of anaerobic power and maximal oxygen uptake (Vo₂max) after intensive exercise. Methods: Thirty nine untrained healthy volunteers were randomized to 3 groups for each intervention: elastic tape, placebo tape and stretching. The participants performed intensive exercise on the dominant quadriceps by using isokinetic dynamometry machine. The recovery process was evaluated by creatine kinase (CK), pressure pain threshold (PPT), muscle soreness scale (MSS), maximum voluntary contraction (MVC), jump height, anaerobic power and Vo₂max at baseline, immediately post-exercise and post-exercise day 1, 2, 3 and 7. Results: The kinesio tape, placebo tape and stretching groups had significant changes of PPT, MVC, jump height at immediately post-exercise compared to baseline (p < 0.05), and changes of MSS, CK, anaerobic power and Vo₂max at day 1 post-exercise compared to baseline (p < 0.05). There was no significant difference of those outcomes among three groups. Additionally, all experimental groups had little effects on anaerobic power and Vo₂max compared to baseline and compared among three groups (p > 0.05). Conclusion: Kinesio tape and stretching did not improve recovery of anaerobic power and Vo₂max after eccentric exercise compared to placebo tape. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=stretching" title="stretching">stretching</a>, <a href="https://publications.waset.org/abstracts/search?q=eccentric%20exercise" title=" eccentric exercise"> eccentric exercise</a>, <a href="https://publications.waset.org/abstracts/search?q=Wingate%20test" title=" Wingate test"> Wingate test</a>, <a href="https://publications.waset.org/abstracts/search?q=muscle%20soreness" title=" muscle soreness"> muscle soreness</a> </p> <a href="https://publications.waset.org/abstracts/103341/effect-of-kinesio-taping-on-anaerobic-power-and-maximum-oxygen-consumption-after-eccentric-exercise" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/103341.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">130</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">970</span> Comparing Trastuzumab-Related Cardiotoxicity between Elderly and Younger Patients with Breast Cancer: A Prospective Cohort Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Afrah%20Aladwani">Afrah Aladwani</a>, <a href="https://publications.waset.org/abstracts/search?q=Alexander%20Mullen"> Alexander Mullen</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20AlRashidi"> Mohammad AlRashidi</a>, <a href="https://publications.waset.org/abstracts/search?q=Omamah%20Alfarisi"> Omamah Alfarisi</a>, <a href="https://publications.waset.org/abstracts/search?q=Faisal%20Alterkit"> Faisal Alterkit</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdulwahab%20Aladwani"> Abdulwahab Aladwani</a>, <a href="https://publications.waset.org/abstracts/search?q=Asit%20Kumar"> Asit Kumar</a>, <a href="https://publications.waset.org/abstracts/search?q=Emad%20Eldosouky"> Emad Eldosouky</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Trastuzumab is a HER-2 targeted humanized monoclonal antibody that significantly improves the therapeutic outcomes of metastatic and non-metastatic breast cancer. However, it is associated with increased risk of cardiotoxicity that ranges from mild decline in the cardiac ejection fraction to permanent cardiomyopathy. Concerns have been raised in treating eligible older patients. This study compares trastuzumab outcomes between two age cohorts in the Kuwait Cancer Control Centre (KCCC). Methods: In a prospective comparative observational study, 93 HER-2 positive breast cancer patients undergoing different chemotherapy protocols + trastuzumab were included and divided into two cohorts based on their age (˂60 and ≥60 years old). The baseline left ventricular ejection fraction (LVEF) was assessed and monitored every three months during trastuzumab treatment. Event of cardiotoxicity was defined as ≥10% decline in the LVEF from the baseline. The lower accepted normal limit of the LVEF was 50%. Results: The median baseline LVEF was 65% in both age cohorts (IQR 8% and 9% for older and younger patients respectively). Whereas, the median LVEF post-trastuzumab treatment was 51% and 55% in older and younger patients respectively (IQR 8%; p-value = 0.22), despite the fact that older patients had significantly lower exposure to anthracyclines compared to younger patients (60% and 84.1% respectively; p-value ˂0.001). 86.7% and 55.6% of older and younger patients, respectively, developed ≥10% decline in their LVEF from the baseline. Among those, only 29% of older and 27% of younger patients reached a LVEF value below 50% (p-value = 0.88). Statistically, age was the only factor that significantly correlated with trastuzumab induced cardiotoxicity (OR 4; p-value ˂0.012), but it did not increase the requirement for permanent discontinuation of treatment. A baseline LVEF value below 60% contributed to developing a post-treatment value below normal ranges (50%). Conclusion: Breast cancer patients aged 60 years and above in Kuwait were at 4-fold higher risk of developing ≥10% decline in their LVEF from the baseline than younger patients during trastuzumab treatment. Surprisingly, previous exposure to anthracyclines and multiple comorbidities were not associated with significant increased risk of cardiotoxicity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title="breast cancer">breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=elderly" title=" elderly"> elderly</a>, <a href="https://publications.waset.org/abstracts/search?q=Trastuzumab" title=" Trastuzumab"> Trastuzumab</a>, <a href="https://publications.waset.org/abstracts/search?q=cardiotoxicity" title=" cardiotoxicity"> cardiotoxicity</a> </p> <a href="https://publications.waset.org/abstracts/135476/comparing-trastuzumab-related-cardiotoxicity-between-elderly-and-younger-patients-with-breast-cancer-a-prospective-cohort-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/135476.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">205</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">969</span> Serum 25-Hydroxyvitamin D Levels and Depression in Persons with Human Immunodeficiency Virus Infection: A Cross-Sectional and Prospective Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kalpana%20Poudel-Tandukar">Kalpana Poudel-Tandukar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Human Immunodeficiency Virus (HIV) infection has been frequently associated with vitamin D deficiency and depression. Vitamin D deficiency increases the risk of depression in people without HIV. We assessed the cross-sectional and prospective associations between serum concentrations of 25-hydroxyvitamin D (25[OH]D) and depression in a HIV-positive people. Methods: A survey was conducted among 316 HIV-positive people aged 20-60 years residing in Kathmandu, Nepal for a cross-sectional association at baseline, and among 184 participants without depressive symptoms at baseline who responded to both baseline (2010) and follow-up (2011) surveys for prospective association. The competitive protein-binding assay was used to measure 25(OH)D levels and the Beck Depression Inventory-Ia method was used to measure depression, with cut off score 20 or higher. Relationships were assessed using multiple logistic regression analysis with adjustment of potential confounders. Results: The proportion of participants with 25(OH)D level of <20ng/mL, 20-30ng/mL, and >30ng/mL were 83.2%, 15.5%, and 1.3%, respectively. Only four participants with 25(OH)D level of >30ng/mL were excluded in the further analysis. The mean 25(OH)D level in men and women were 15.0ng/mL and 14.4ng/mL, respectively. Twenty six percent of participants (men:23%; women:29%) were depressed. Participants with 25(OH)D level of < 20 ng/mL had a 1.4 fold higher odds of depression in a cross-sectional and 1.3 fold higher odds of depression after 18 months of baseline compared to those with 25(OH)D level of 20-30ng/mL (p=0.40 and p=0.78, respectively). Conclusion: Vitamin D may not have significant impact against depression among HIV-positive people with 25(OH)D level below normal ( > 30ng/mL). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=depression" title="depression">depression</a>, <a href="https://publications.waset.org/abstracts/search?q=HIV" title=" HIV"> HIV</a>, <a href="https://publications.waset.org/abstracts/search?q=Nepal" title=" Nepal"> Nepal</a>, <a href="https://publications.waset.org/abstracts/search?q=vitamin%20D" title=" vitamin D"> vitamin D</a> </p> <a href="https://publications.waset.org/abstracts/38676/serum-25-hydroxyvitamin-d-levels-and-depression-in-persons-with-human-immunodeficiency-virus-infection-a-cross-sectional-and-prospective-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/38676.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">332</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">968</span> Schema Therapy as Treatment for Adults with Autism Spectrum Disorder and Comorbid Personality Disorder: A Multiple Baseline Case Series Study Testing Cognitive-Behavioral and Experiential Interventions</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Richard%20Vuijk">Richard Vuijk</a>, <a href="https://publications.waset.org/abstracts/search?q=Arnoud%20Arntz"> Arnoud Arntz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Rationale: To our knowledge treatment of personality disorder comorbidity in adults with autism spectrum disorder (ASD) is understudied and is still in its infancy: We do not know if treatment of personality disorders may be applicable to adults with ASD. In particular, it is unknown whether patients with ASD benefit from experiential techniques that are part of schema therapy developed for the treatment of personality disorders. Objective: The aim of the study is to investigate the efficacy of a schema mode focused treatment with adult clients with ASD and comorbid personality pathology (i.e. at least one personality disorder). Specifically, we investigate if they can benefit from both cognitive-behavioral, and experiential interventions. Study design: A multiple baseline case series study. Study population: Adult individuals (age > 21 years) with ASD and at least one personality disorder. Participants will be recruited from Sarr expertise center for autism in Rotterdam. The study requires 12 participants. Intervention: The treatment protocol consists of 35 weekly offered sessions, followed by 10 monthly booster sessions. A multiple baseline design will be used with baseline varying from 5 to 10 weeks, with weekly supportive sessions. After baseline, a 5-week exploration phase follows with weekly sessions during which current and past functioning, psychological symptoms, schema modes are explored, and information about the treatment will be given. Then 15 weekly sessions with cognitive-behavioral interventions and 15 weekly sessions with experiential interventions will be given. Finally, there will be a 10-month follow-up phase with monthly booster sessions. Participants are randomly assigned to baseline length, and respond weekly during treatment and monthly at follow-up on Belief Strength of negative core beliefs (by VAS), and fill out SMI, SCL-90 and SRS-A 7 times during screening procedure (i.e. before baseline), after baseline, after exploration, after cognitive and behavioral interventions, after experiential interventions, and after 5- and 10- month follow-up. The SCID-II will be administered during screening procedure (i.e. before baseline), at 5- and at 10-month follow-up. Main study parameters: The primary study parameter is negative core beliefs. Secondary study parameters include schema modes, personality disorder manifestations, psychological symptoms, and social interaction and communication. Discussion: To the best of author’s knowledge so far no study has been published on the application of schema mode focused interventions in adult patients with ASD and comorbid PD(s). This study offers the first systematic test of application of schema therapy for adults with ASD. The results of this study will provide initial evidence for the effectiveness of schema therapy in treating adults with both ASD and PD(s). The study intends to provide valuable information for future development and implementation of therapeutic interventions for adults with both ASD and PD(s). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=adults" title="adults">adults</a>, <a href="https://publications.waset.org/abstracts/search?q=autism%20spectrum%20disorder" title=" autism spectrum disorder"> autism spectrum disorder</a>, <a href="https://publications.waset.org/abstracts/search?q=personality%20disorder" title=" personality disorder"> personality disorder</a>, <a href="https://publications.waset.org/abstracts/search?q=schema%20therapy" title=" schema therapy"> schema therapy</a> </p> <a href="https://publications.waset.org/abstracts/47400/schema-therapy-as-treatment-for-adults-with-autism-spectrum-disorder-and-comorbid-personality-disorder-a-multiple-baseline-case-series-study-testing-cognitive-behavioral-and-experiential-interventions" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/47400.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">239</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">967</span> Effects of Oral L-Carnitine on Liver Functions after Trans arterial Chemoembolization in Hepatocellular Carcinoma Patients</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ali%20Kassem">Ali Kassem</a>, <a href="https://publications.waset.org/abstracts/search?q=Aly%20Taha"> Aly Taha</a>, <a href="https://publications.waset.org/abstracts/search?q=Abeer%20Hassan"> Abeer Hassan</a>, <a href="https://publications.waset.org/abstracts/search?q=Kazuhide%20Higuchi"> Kazuhide Higuchi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Trans arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) is usually followed by hepatic dysfunction that limits its efficacy. L-carnitine is recently studied as hepatoprotective agent. Our aim is to evaluate the L-carnitine effects against the deterioration of liver functions after TACE. Method: 53 patients with intermediate stage HCC were assigned into two groups; L-carnitine group (26 patients) who received L-carnitine 300 mg tablet twice daily from 2 weeks before to 12 weeks after TACE and control group (27 patients) without L-carnitine therapy. 28 of studied patients received branched chain amino acids granules. Results: There were significant differences between L-carnitine Vs. control group in mean serum albumin change from baseline to 1 week and 4 weeks after TACE (p < 0.05). L-Carnitine maintained Child-Pugh score at 1 week after TACE and exhibited improvement at 4 weeks after TACE (p < 0.01 Vs 1 week after TACE). Control group has significant Child-Pugh score deterioration from baseline to 1 week after TACE (p < 0.05) and 12 weeks after TACE (p < 0.05). There were significant differences between L-carnitine and control groups in mean Child-Pugh score change from baseline to 4 weeks (p < 0.05) and 12 weeks after TACE (p < 0.05). L-carnitine displayed improvement in (PT) from baseline to 1 week, 4 w (p < 0.05) and 12 weeks after TACE. PT in control group declined less than baseline along all follow up intervals. Total bilirubin in L-carnitine group decreased at 1 week post TACE while in control group, it significantly increased at 1 week (p = 0.01). ALT and C-reactive protein elevation were suppressed at 1 week after TACE in Lcarnitine group. The hepatoprotective effects of L-carnitine were enhanced by concomitant use of branched chain amino acids. Conclusion: L-carnitine and BCAA combination therapy offer a novel supportive strategy after TACE in HCC patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hepatocellular%20carcinoma" title="hepatocellular carcinoma">hepatocellular carcinoma</a>, <a href="https://publications.waset.org/abstracts/search?q=L-carnitine" title=" L-carnitine"> L-carnitine</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20functions" title=" liver functions "> liver functions </a>, <a href="https://publications.waset.org/abstracts/search?q=trans-arterial%20embolization" title=" trans-arterial embolization"> trans-arterial embolization</a> </p> <a href="https://publications.waset.org/abstracts/94742/effects-of-oral-l-carnitine-on-liver-functions-after-trans-arterial-chemoembolization-in-hepatocellular-carcinoma-patients" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/94742.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">155</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">966</span> Dietary Modification and Its Effects in Overweight or Obese Saudi Women with or without Type 2 Diabetes Mellitus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nasiruddin%20Khan">Nasiruddin Khan</a>, <a href="https://publications.waset.org/abstracts/search?q=Nasser%20M.%20Al-Daghri"> Nasser M. Al-Daghri</a>, <a href="https://publications.waset.org/abstracts/search?q=Dara%20A.%20Al-Disi"> Dara A. Al-Disi</a>, <a href="https://publications.waset.org/abstracts/search?q=Asim%20Al-Fadda"> Asim Al-Fadda</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20Al-Seif"> Mohamed Al-Seif</a>, <a href="https://publications.waset.org/abstracts/search?q=Gyanendra%20Tripathi"> Gyanendra Tripathi</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20L.%20Harte"> A. L. Harte</a>, <a href="https://publications.waset.org/abstracts/search?q=Philip%20G.%20Mcternan"> Philip G. Mcternan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> For the last few decades, the prevalence of type 2 diabetes mellitus (T2DM) in the Kingdom of Saudi Arabia (KSA) is increasing alarmingly high and is unprecedented at 31.6 %. Preventive measures should be taken to curb down the increasing incidence. In this prospective, 3-month study, we aimed to determine whether dietary modification program would confer favorable affects among overweight and obese adult Saudi women with or without T2DM. A total of 92 Saudi women [18 healthy controls, 24 overweight subjects and 50 overweight or obese patients with early onset T2DM were included in this prospective study. Baseline anthropometrics and fasting blood samples were taken at baseline and after 3 months. Fasting blood sugar and lipid profile were measured routinely. A 500 Kcal deficit energy diet less than their daily recommended dietary allowances were prescribed to all participants. After 3 months of follow-up visit, significant improvements were observed in both the overweight and DMT2 group as compared to baseline with decreased mean BMI [Overweight Group 28.54±1.49 versus 27.95±2.25, p<0.05; DMT2 group 35.24±7.67 versus 35.04±8.07, p<0.05] and hip circumference [Overweight group 109.67±5.01 versus 108.07±4.07, p<0.05; DMT2 group 112.3±13.43 versus 109.21±12.71, p<0.01]. Moreover, in the overweight group, baseline HDL-cholesterol was significantly associated with protein intake and inversely associated with carbohydrate intake in controls. In the DMT2 group, carbohydrate intake at baseline was significantly associated with BMI. A 3-month 500kcal/day deficit dietary modification alone is probably effective among adult overweight or obese Saudi females without or with T2DM. Longer prospective studies are to determine whether the dietary intervention alone can reduce progression of T2DM among high-risk adult Arabs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diet" title="diet">diet</a>, <a href="https://publications.waset.org/abstracts/search?q=lipid" title=" lipid"> lipid</a>, <a href="https://publications.waset.org/abstracts/search?q=obesity" title=" obesity"> obesity</a>, <a href="https://publications.waset.org/abstracts/search?q=T2DM" title=" T2DM"> T2DM</a> </p> <a href="https://publications.waset.org/abstracts/19098/dietary-modification-and-its-effects-in-overweight-or-obese-saudi-women-with-or-without-type-2-diabetes-mellitus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19098.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">475</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">965</span> Efficacy of Heart Failure Reversal Treatment Followed by 90 Days Follow up in Chronic Heart Failure Patients with Low Ejection Fraction</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rohit%20Sane">Rohit Sane</a>, <a href="https://publications.waset.org/abstracts/search?q=Snehal%20Dongre"> Snehal Dongre</a>, <a href="https://publications.waset.org/abstracts/search?q=Pravin%20Ghadigaonkar"> Pravin Ghadigaonkar</a>, <a href="https://publications.waset.org/abstracts/search?q=Rahul%20Mandole"> Rahul Mandole</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study was designed to evaluate efficacy of heart failure reversal therapy (HFRT) that uses herbal procedure (panchakarma) and allied therapies, in chronic heart failure (CHF) patients with low ejection fraction. Methods: This efficacy study was conducted in CHF patients (aged: 25-65 years, ejection fraction (EF) < 30%) wherein HFRT (60-75 minutes) consisting of snehana (external oleation), swedana (passive heat therapy), hrudaydhara(concoction dripping treatment) and basti(enema) was administered twice daily for 7 days. During this therapy and next 30 days, patients followed the study dinarcharya and were prescribed ARJ kadha in addition to their conventional treatment. The primary endpoint of this study was evaluation of maximum aerobic capacity uptake (MAC) as assessed by 6-minute walk distance (6MWD) using Cahalins equation from baseline, at end of 7 day treatment, follow-up after 30 days and 90 days. EF was assessed by 2D Echo at baseline and after 30 days of follow-up. Results: CHF patients with < 30% EF (N=52, mean [SD] age: 58.8 [10.8], 85% men) were enrolled in the study. There was a 100% compliance to study therapy. A significant improvement was observed in MAC levels (7.11%, p =0.029), at end of 7 day therapy as compared to baseline. This improvement was maintained at two follow-up visits. Moreover, ejection fraction was observed to be increased by 6.38%, p=0,012 as compared to baseline at day 7 of the therapy. Conclusions: This 90 day follow up study highlights benefit of HFRT, as a part of maintenance treatment for CHF patients with reduced ejection fraction. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chronic%20heart%20failure" title="chronic heart failure">chronic heart failure</a>, <a href="https://publications.waset.org/abstracts/search?q=functional%20capacity" title=" functional capacity"> functional capacity</a>, <a href="https://publications.waset.org/abstracts/search?q=heart%20failure%20reversal%20therapy" title=" heart failure reversal therapy"> heart failure reversal therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=oxygen%20uptake" title=" oxygen uptake"> oxygen uptake</a>, <a href="https://publications.waset.org/abstracts/search?q=panchakarma" title=" panchakarma"> panchakarma</a> </p> <a href="https://publications.waset.org/abstracts/80349/efficacy-of-heart-failure-reversal-treatment-followed-by-90-days-follow-up-in-chronic-heart-failure-patients-with-low-ejection-fraction" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/80349.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">233</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">964</span> Rosuvastatin Improves Endothelial Progenitor Cells in Rheumatoid Arthritis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ashit%20Syngle">Ashit Syngle</a>, <a href="https://publications.waset.org/abstracts/search?q=Nidhi%20Garg"> Nidhi Garg</a>, <a href="https://publications.waset.org/abstracts/search?q=Pawan%20Krishan"> Pawan Krishan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Endothelial Progenitor Cells (EPCs) are depleted and contribute to increased cardiovascular (CV) risk in rheumatoid arthritis (RA). Statins exert a protective effect in CAD partly by promoting EPC mobilization. This vasculoprotective effect of statin has not yet been investigated in RA. We aimed to investigate the effect of rosuvastatin on EPCs in RA. Methods: 50 RA patients were randomized to receive 6 months of treatment with rosuvastatin (10 mg/day, n=25) and placebo (n=25) as an adjunct to existing stable antirheumatic drugs. EPCs (CD34+/CD133+) were quantified by Flow Cytometry. Inflammatory measures included DAS28, CRP and ESR were measured at baseline and after treatment. Lipids and pro-inflammatory cytokines (TNF-α, IL-6, and IL-1) were estimated at baseline and after treatment. Results: At baseline, inflammatory measures and pro-inflammatory cytokines were elevated and EPCs depleted among both groups. At baseline, EPCs inversely correlated with DAS28 and TNF-α in both groups. EPCs increased significantly (p < 0.01) after treatment with rosuvastatin but did not show significant change with placebo. Rosuvastatin exerted positive effect on lipid spectrum: lowering total cholesterol, LDL, non HDL and elevation of HDL as compared with placebo. At 6 months, DAS28, ESR, CRP, TNF-α and IL-6 improved significantly in rosuvastatin group. Significant negative correlation was observed between EPCs and DAS28, CRP, TNF-α, and IL-6 after treatment with rosuvastatin. Conclusion: First study to show that rosuvastatin improves inflammation and EPC biology in RA possibly through its anti-inflammatory and lipid lowering effect. This beneficial effect of rosuvastatin may provide a novel strategy to prevent cardiovascular events in RA. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=RA" title="RA">RA</a>, <a href="https://publications.waset.org/abstracts/search?q=Endothelial%20Progenitor%20Cells" title=" Endothelial Progenitor Cells"> Endothelial Progenitor Cells</a>, <a href="https://publications.waset.org/abstracts/search?q=rosuvastatin" title=" rosuvastatin"> rosuvastatin</a>, <a href="https://publications.waset.org/abstracts/search?q=cytokines" title=" cytokines "> cytokines </a> </p> <a href="https://publications.waset.org/abstracts/17374/rosuvastatin-improves-endothelial-progenitor-cells-in-rheumatoid-arthritis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/17374.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">258</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">963</span> An Online Adaptive Thresholding Method to Classify Google Trends Data Anomalies for Investor Sentiment Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Duygu%20Dere">Duygu Dere</a>, <a href="https://publications.waset.org/abstracts/search?q=Mert%20Ergeneci"> Mert Ergeneci</a>, <a href="https://publications.waset.org/abstracts/search?q=Kaan%20Gokcesu"> Kaan Gokcesu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Google Trends data has gained increasing popularity in the applications of behavioral finance, decision science and risk management. Because of Google’s wide range of use, the Trends statistics provide significant information about the investor sentiment and intention, which can be used as decisive factors for corporate and risk management fields. However, an anomaly, a significant increase or decrease, in a certain query cannot be detected by the state of the art applications of computation due to the random baseline noise of the Trends data, which is modelled as an Additive white Gaussian noise (AWGN). Since through time, the baseline noise power shows a gradual change an adaptive thresholding method is required to track and learn the baseline noise for a correct classification. To this end, we introduce an online method to classify meaningful deviations in Google Trends data. Through extensive experiments, we demonstrate that our method can successfully classify various anomalies for plenty of different data. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=adaptive%20data%20processing" title="adaptive data processing">adaptive data processing</a>, <a href="https://publications.waset.org/abstracts/search?q=behavioral%20finance" title=" behavioral finance "> behavioral finance </a>, <a href="https://publications.waset.org/abstracts/search?q=convex%20optimization" title=" convex optimization"> convex optimization</a>, <a href="https://publications.waset.org/abstracts/search?q=online%20learning" title=" online learning"> online learning</a>, <a href="https://publications.waset.org/abstracts/search?q=soft%20minimum%20thresholding" title=" soft minimum thresholding"> soft minimum thresholding</a> </p> <a href="https://publications.waset.org/abstracts/92282/an-online-adaptive-thresholding-method-to-classify-google-trends-data-anomalies-for-investor-sentiment-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/92282.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">167</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">962</span> PatchMix: Learning Transferable Semi-Supervised Representation by Predicting Patches</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Arpit%20Rai">Arpit Rai</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this work, we propose PatchMix, a semi-supervised method for pre-training visual representations. PatchMix mixes patches of two images and then solves an auxiliary task of predicting the label of each patch in the mixed image. Our experiments on the CIFAR-10, 100 and the SVHN dataset show that the representations learned by this method encodes useful information for transfer to new tasks and outperform the baseline Residual Network encoders by on CIFAR 10 by 12% on ResNet 101 and 2% on ResNet-56, by 4% on CIFAR-100 on ResNet101 and by 6% on SVHN dataset on the ResNet-101 baseline model. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=self-supervised%20learning" title="self-supervised learning">self-supervised learning</a>, <a href="https://publications.waset.org/abstracts/search?q=representation%20learning" title=" representation learning"> representation learning</a>, <a href="https://publications.waset.org/abstracts/search?q=computer%20vision" title=" computer vision"> computer vision</a>, <a href="https://publications.waset.org/abstracts/search?q=generalization" title=" generalization"> generalization</a> </p> <a href="https://publications.waset.org/abstracts/150013/patchmix-learning-transferable-semi-supervised-representation-by-predicting-patches" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/150013.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">89</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">961</span> InSAR Times-Series Phase Unwrapping for Urban Areas</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hui%20Luo">Hui Luo</a>, <a href="https://publications.waset.org/abstracts/search?q=Zhenhong%20Li"> Zhenhong Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Zhen%20Dong"> Zhen Dong</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The analysis of multi-temporal InSAR (MTInSAR) such as persistent scatterer (PS) and small baseline subset (SBAS) techniques usually relies on temporal/spatial phase unwrapping (PU). Unfortunately, it always fails to unwrap the phase for two reasons: 1) spatial phase jump between adjacent pixels larger than π, such as layover and high discontinuous terrain; 2) temporal phase discontinuities such as time varied atmospheric delay. To overcome these limitations, a least-square based PU method is introduced in this paper, which incorporates baseline-combination interferograms and adjacent phase gradient network. Firstly, permanent scatterers (PS) are selected for study. Starting with the linear baseline-combination method, we obtain equivalent 'small baseline inteferograms' to limit the spatial phase difference. Then, phase different has been conducted between connected PSs (connected by a specific networking rule) to suppress the spatial correlated phase errors such as atmospheric artifact. After that, interval phase difference along arcs can be computed by least square method and followed by an outlier detector to remove the arcs with phase ambiguities. Then, the unwrapped phase can be obtained by spatial integration. The proposed method is tested on real data of TerraSAR-X, and the results are also compared with the ones obtained by StaMPS(a software package with 3D PU capabilities). By comparison, it shows that the proposed method can successfully unwrap the interferograms in urban areas even when high discontinuities exist, while StaMPS fails. At last, precise DEM errors can be got according to the unwrapped interferograms. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=phase%20unwrapping" title="phase unwrapping">phase unwrapping</a>, <a href="https://publications.waset.org/abstracts/search?q=time%20series" title=" time series"> time series</a>, <a href="https://publications.waset.org/abstracts/search?q=InSAR" title=" InSAR"> InSAR</a>, <a href="https://publications.waset.org/abstracts/search?q=urban%20areas" title=" urban areas"> urban areas</a> </p> <a href="https://publications.waset.org/abstracts/97800/insar-times-series-phase-unwrapping-for-urban-areas" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/97800.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">151</span> </span> </div> </div> <ul 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