Mouse TIM-3 Antibody AF1529: R&D Systems

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class="ds_title">Mouse TIM-3 Antibody </h1> <div class="dsSprite_rnd ds_brand_logo ds_rnd_logo"></div> </div> <div class="product_meta"> <span class="category_number">Catalog #: AF1529</span> <br/> <span class="citations"> <a href="#product-citations" id="citation_count" class="jump_to" data-tab="3" data-tabname="product-citations"> 4 Citations </a> </span> <a href="/reviews/AF1529" rel="nofollow"><span class="submit_review"><button class="btn btn-quaternary">Submit a Review</button></span></a> <span class="datasheet_link"> <a href="#product-datasheets">Datasheet / COA / SDS</a> </span> </div>  <div class="product_wrapper row"> <div class="product_ordering_wrapper col-xs-12 col-md-8 col-md-push-4"> <div class="product_ordering"> <form action="/products/mouse-tim-3-antibody_af1529" method="post" id="atc-datasheet-form" accept-charset="UTF-8"><div><div id="atc_datasheet_block">     <table class="add_to_cart"> <thead> <tr> <th class="ds_catalog">Catalog #</th> <th 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class="ds_atc_post_buttons"></div> </div> <input type="hidden" name="form_build_id" value="form-GsvRsQsZnW-tDmV5HenNHXgXsQzVd67FeazKmv9sNSc" /> <input type="hidden" name="form_id" value="atc_datasheet_form" /> </div></form> </div> </div> <div class="product_image_wrapper col-xs-12 col-md-4 col-md-pull-8"> <div class="product_image"> <span class="product_image_label"> </span> <a class="ds-image overview-images" data-toggle="lightbox" data-gallery="overview-images" onClick="event.preventDefault();" data-title="Detection of Mouse TIM‑3 by Western Blot." data-footer="Detection of Mouse TIM‑3 by Western Blot." title="Cat. No. AF1529 - Mouse TIM-3 Antibody" href="https://resources.rndsystems.com/images/datasheets/antibody/TIM3_AF1529_Western_Blot_23436.jpg"> <img fetchpriority="high" src="https://resources.rndsystems.com/images/datasheets/antibody/TIM3_AF1529_Western_Blot_23436.jpg" class="img-fluid" alt="Detection of Mouse TIM‑3 by Western Blot." title="Detection of Mouse TIM‑3 by Western Blot."> </a> <div class="search_image_other_count"> <span class="search_more_images">5 Images</span> </div> </div> </div> <div id="extra_images overview-images" class="hidden"> <a class="ds-image" data-toggle="lightbox" data-gallery="overview-images" data-footer="TIM‑3 in Mouse Spleen." data-title="TIM‑3 in Mouse Spleen." title="Cat. No. AF1529 - Mouse TIM-3 Antibody" onClick="event.preventDefault();" href="https://resources.rndsystems.com/images/datasheets/antibody/af1529_mouse-tim-3-affinity-purified-polyclonal-ab-immunohistochemistry-7122021133156.jpg"> <img src="https://resources.rndsystems.com/images/datasheets/antibody/af1529_mouse-tim-3-affinity-purified-polyclonal-ab-immunohistochemistry-7122021133156.jpg" class="img-fluid" loading="lazy" alt="TIM‑3 in Mouse Spleen." title="TIM‑3 in Mouse Spleen."> </a> <a class="ds-image" data-toggle="lightbox" data-gallery="overview-images" data-footer="Detection of Mouse TIM-3 by Immunohistochemistry" data-title="Detection of Mouse TIM-3 by Immunohistochemistry" title="Cat. No. AF1529 - Mouse TIM-3 Antibody" onClick="event.preventDefault();" href="https://resources.rndsystems.com/images/datasheets/af1529_mouse-tim-3-affinity-purified-polyclonal-ab-4120241240217.jpg"> <img src="https://resources.rndsystems.com/images/datasheets/af1529_mouse-tim-3-affinity-purified-polyclonal-ab-4120241240217.jpg" class="img-fluid" loading="lazy" alt="Detection of Mouse TIM-3 by Immunohistochemistry" title="Detection of Mouse TIM-3 by Immunohistochemistry"> </a> <a class="ds-image" data-toggle="lightbox" data-gallery="overview-images" data-footer="Detection of Mouse TIM-3 by Immunohistochemistry" data-title="Detection of Mouse TIM-3 by Immunohistochemistry" title="Cat. No. AF1529 - Mouse TIM-3 Antibody" onClick="event.preventDefault();" href="https://resources.rndsystems.com/images/datasheets/af1529_mouse-tim-3-affinity-purified-polyclonal-ab-41202412403511.jpg"> <img src="https://resources.rndsystems.com/images/datasheets/af1529_mouse-tim-3-affinity-purified-polyclonal-ab-41202412403511.jpg" class="img-fluid" loading="lazy" alt="Detection of Mouse TIM-3 by Immunohistochemistry" title="Detection of Mouse TIM-3 by Immunohistochemistry"> </a> <a class="ds-image" data-toggle="lightbox" data-gallery="overview-images" data-footer="Detection of Mouse TIM-3 by Immunohistochemistry" data-title="Detection of Mouse TIM-3 by Immunohistochemistry" title="Cat. No. AF1529 - Mouse TIM-3 Antibody" onClick="event.preventDefault();" href="https://resources.rndsystems.com/images/datasheets/af1529_mouse-tim-3-affinity-purified-polyclonal-ab-41202412402532.jpg"> <img src="https://resources.rndsystems.com/images/datasheets/af1529_mouse-tim-3-affinity-purified-polyclonal-ab-41202412402532.jpg" class="img-fluid" loading="lazy" alt="Detection of Mouse TIM-3 by Immunohistochemistry" title="Detection of Mouse TIM-3 by Immunohistochemistry"> </a> </div> </div> <div class="product_info_wrapper"> </div> <div id="view-more-target" class="datasheet_section_element"> <a href="/target/tim-3?category=Primary Antibodies" class="btn btn-secondary">All TIM-3 Antibodies</a> </div> </div> <div class="tabbed_content" id="rnd_antibody"> <div id="ds_tabs" class="tab_menu"> <div class="tab tab_1 tab_open" data-tab="1" data-tabname="product-details" id="dsTabs_product-details"> <span>Product Details</span> </div> <div class="tab tab_3" data-tab="3" data-tabname="product-citations" id="dsTabs_product-citations"> <span>Citations (4)</span> </div> <div class="tab tab_4" data-tab="4" data-tabname="faqs" id="dsTabs_faqs"> <span>FAQs</span> </div> <div class="tab tab_5" data-tab="5" data-tabname="supplemental-products" id="dsTabs_supplemental-products"> <span>Supplemental Products</span> </div> <div class="tab tab_6" data-tab="6" data-tabname="product-reviews" id="dsTabs_product-reviews"> <span> Reviews </span> </div> </div> <div class="tab_content tab_1 tab_open" data-tab="1" data-tabname="product-details" id="product-details"> <div class="datasheet_section_element"> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_summary" id="product-anchor-ds_summary">Summary</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_data_examples" id="product-anchor-ds_data_examples">Data Examples</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_preparation_storage" id="product-anchor-ds_preparation_storage">Preparation and Storage</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_calculator" id="product-anchor-ds_calculator">Reconstitution Calculator</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_background" id="product-anchor-ds_background">Background</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_datasheets" id="product-anchor-ds_datasheets">Product Datasheets</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_related_research_areas" id="product-anchor-ds_related_research_areas">Related Research Areas</a> </div> <h2 id="ds_summary">Mouse TIM-3 Antibody Summary</h2> <div class="datasheet_section"> <div class="ds_table summary_table"> <div class="ds_table_body">  <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Species Reactivity</div> <div class="ds_table_cell summary_table_data"> Mouse </div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Specificity</div> <div class="ds_table_cell summary_table_data"> Detects mouse TIM-3 in direct ELISAs and  Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant human TIM‑3 is observed and less than 5% cross-reactivity with recombinant mouse (rm) TIM‑1, rmTIM‑2, rmTIM‑4, rmTIM‑5, rmTIM‑6, and rmTIM‑7 is observed. </div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Source</div> <div class="ds_table_cell summary_table_data"> Polyclonal Goat IgG </div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Purification</div> <div class="ds_table_cell summary_table_data"> Antigen Affinity-purified </div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Immunogen</div> <div class="ds_table_cell summary_table_data"> Mouse myeloma cell line NS0-derived recombinant mouse TIM‑3<br />Leu22-Arg191<br />Accession # AAL65156 </div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Formulation</div> <div class="ds_table_cell summary_table_data"> Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. </div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Label</div> <div class="ds_table_cell summary_table_data"> Unconjugated </div> </div> </div> </div> </div> <div id="customer_also_purchased_block" class="loader" data-catalogId="AF1529"></div> <div id="ds_applications" class="datasheet_section"> <h2>Applications</h2> <div class="ds_table app_table"> <div class="ds_table_head"> <div class="ds_table_head_row"> <div class="ds_table_head_cell app_table_blank"></div> <div class="ds_table_head_cell app_table_rec_conc">Recommended Concentration</div> <div class="ds_table_head_cell app_table_sample">Sample</div> </div> </div> <div class="ds_table_body"> <div class="ds_table_row"> <div class="ds_table_cell app_table_name">Western Blot</div> <div class="ds_table_cell app_table_dilution">2 µg/mL</div> <div class="ds_table_cell app_table_sample">See below</div> </div> <div class="ds_table_row"> <div class="ds_table_cell app_table_name">Flow Cytometry</div> <div class="ds_table_cell app_table_dilution">2.5 µg/10<sup>6</sup> cells</div> <div class="ds_table_cell app_table_sample">HT‑2 mouse T cell line</div> </div> <div class="ds_table_row"> <div class="ds_table_cell app_table_name ich_cell">Immunohistochemistry</div> <div class="ds_table_cell app_table_dilution">3-15 µg/mL</div> <div class="ds_table_cell app_table_sample">Immersion fixed paraffin-embedded sections of mouse spleen</div> </div> <div class="ds_table_row"> <div class="ds_table_cell app_table_name2">CyTOF-ready</div> <div class="ds_table_cell app_table_freeform">Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.</div> <div class="ds_table_cell app_table_sample"> </div> </div> </div> </div> <p>Please Note: Optimal dilutions should be determined by each laboratory for each application. <a href="/resources/protocols-troubleshooting-guides">General Protocols</a> are available in the Technical Information section on our website. </p> </div> <div id="ds_scientific_data" class="datasheet_section"> <div id="ds_data_examples"> <h2>Scientific Data</h2> <div id="data_examples"> <div class="row data_ex_row"> <a id="ds_image_0" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> Western Blot </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-0" data-title="Detection of Mouse TIM‑3 by Western Blot." data-footer="Detection of Mouse TIM-3 antibody by Western Blot." title="Cat. No. AF1529 - Detection of Mouse TIM-3 antibody by Western Blot." href="https://resources.rndsystems.com/images/datasheets/antibody/TIM3_AF1529_Western_Blot_23436.jpg"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/antibody/TIM3_AF1529_Western_Blot_23436.jpg" class="img-fluid" alt="Detection of Mouse TIM-3 antibody by Western Blot." title="Detection of Mouse TIM-3 antibody by Western Blot."> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> <span class="data_ex_description_title">Detection of Mouse TIM‑3 by Western Blot.</span> Western blot shows lysates of RAW 264.7 mouse monocyte/macrophage cell line. PVDF membrane was probed with 2 µg/mL of Goat Anti-Mouse TIM-3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1529) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class="NoLineLink" href="https://www.rndsystems.com/products/goat-igg-hrp-conjugated-antibody_haf017">HAF017</a>). A specific band was detected for TIM-3 at approximately 45-70 kDa (as indicated). This experiment was conducted under reducing conditions and using <a class="NoLineLink" href="https://www.rndsystems.com/go/westernblotconditions">Immunoblot Buffer Group 1</a>. </p> </div> </div> <div class="row data_ex_row"> <a id="ds_image_1" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> Immunohistochemistry </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-1" data-title="TIM‑3 in Mouse Spleen." data-footer="" title="Cat. No. AF1529 - " href="https://resources.rndsystems.com/images/datasheets/antibody/af1529_mouse-tim-3-affinity-purified-polyclonal-ab-immunohistochemistry-7122021133156.jpg"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/antibody/af1529_mouse-tim-3-affinity-purified-polyclonal-ab-immunohistochemistry-7122021133156.jpg" class="img-fluid" alt="" title=""> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> <span class="data_ex_description_title">TIM‑3 in Mouse Spleen.</span> TIM‑3 was detected in immersion fixed paraffin-embedded sections of mouse spleen using Goat Anti-Mouse TIM‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1529) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (<a class="NoLineLink" href="https://www.rndsystems.com/products/goat-igg-visucyte-hrp-polymer_vc004">VC004</a>). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (<a class="NoLineLink" href="https://www.rndsystems.com/products/antigen-retrieval-reagent-basic_cts013">CTS013</a>). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to lymphocytes. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents. </p> </div> </div> <div class="row data_ex_row"> <a id="ds_image_2" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> Immunohistochemistry </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-2" data-title="Detection of Mouse TIM-3 by Immunohistochemistry" data-footer="Detection of Mouse TIM-3 by Immunohistochemistry" title="Cat. No. AF1529 - Detection of Mouse TIM-3 by Immunohistochemistry" href="https://resources.rndsystems.com/images/datasheets/af1529_mouse-tim-3-affinity-purified-polyclonal-ab-4120241240217.jpg"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/af1529_mouse-tim-3-affinity-purified-polyclonal-ab-4120241240217.jpg" class="img-fluid" alt="Detection of Mouse TIM-3 by Immunohistochemistry" title="Detection of Mouse TIM-3 by Immunohistochemistry"> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> <span class="data_ex_description_title">Detection of Mouse TIM-3 by Immunohistochemistry</span> Blocking TIM-3 significantly reduces brain injury after hypoxia-ischaemia.(a) Representative images of TTC-stained brain slices from H/I mice treated with 100 μg of IgG (n=12) or anti-TIM-3 antibody (n=12). The infarct volume was quantified with Image J analyser and expressed as a percentage of the damaged ipsilateral hemisphere. (b) Representative magnetic resonance images (MRIs) from TIM-3-antibody-treated mice (n=4) and IgG-treated mice (n=4) at 24 h post-H/I. (c) Representative T2 images from TIM-3-antibody-treated mice (n=4) and IgG-treated mice (n=4) after H/I. (d) The extent of the oedema formation was obtained from the T2-weighted MRI images and ADC map. (e) Representative confocal microscopic images of immunohistochemical staining for NeuN and cleaved caspase-3 in coronal brain sections from IgG- and anti-TIM-3-treated H/I mice 24 h after injury. Scale bar, 50 μm. The graph shows the mean number of NeuN and cleaved caspase-3-stained cells per mm2. (f) Immunoblot detection of full-length PARP proteins in contralateral and ipsilateral cortex regions of control IgG- or anti-TIM-3-treated mice. The graph shows the relative levels of full-length PARP (116 kDa). Data represent the mean±s.d. from at least three independent experiments. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/25790768), licensed under a CC-BY license. Not internally tested by R&D Systems. </p> </div> </div> <div class="row data_ex_row"> <a id="ds_image_3" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> Immunohistochemistry </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-3" data-title="Detection of Mouse TIM-3 by Immunohistochemistry" data-footer="Detection of Mouse TIM-3 by Immunohistochemistry" title="Cat. No. AF1529 - Detection of Mouse TIM-3 by Immunohistochemistry" href="https://resources.rndsystems.com/images/datasheets/af1529_mouse-tim-3-affinity-purified-polyclonal-ab-41202412403511.jpg"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/af1529_mouse-tim-3-affinity-purified-polyclonal-ab-41202412403511.jpg" class="img-fluid" alt="Detection of Mouse TIM-3 by Immunohistochemistry" title="Detection of Mouse TIM-3 by Immunohistochemistry"> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> <span class="data_ex_description_title">Detection of Mouse TIM-3 by Immunohistochemistry</span> Blocking TIM-3 significantly reduces brain injury after hypoxia-ischaemia.(a) Representative images of TTC-stained brain slices from H/I mice treated with 100 μg of IgG (n=12) or anti-TIM-3 antibody (n=12). The infarct volume was quantified with Image J analyser and expressed as a percentage of the damaged ipsilateral hemisphere. (b) Representative magnetic resonance images (MRIs) from TIM-3-antibody-treated mice (n=4) and IgG-treated mice (n=4) at 24 h post-H/I. (c) Representative T2 images from TIM-3-antibody-treated mice (n=4) and IgG-treated mice (n=4) after H/I. (d) The extent of the oedema formation was obtained from the T2-weighted MRI images and ADC map. (e) Representative confocal microscopic images of immunohistochemical staining for NeuN and cleaved caspase-3 in coronal brain sections from IgG- and anti-TIM-3-treated H/I mice 24 h after injury. Scale bar, 50 μm. The graph shows the mean number of NeuN and cleaved caspase-3-stained cells per mm2. (f) Immunoblot detection of full-length PARP proteins in contralateral and ipsilateral cortex regions of control IgG- or anti-TIM-3-treated mice. The graph shows the relative levels of full-length PARP (116 kDa). Data represent the mean±s.d. from at least three independent experiments. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/25790768), licensed under a CC-BY license. Not internally tested by R&D Systems. </p> </div> </div> <div class="row data_ex_row"> <a id="ds_image_4" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> Immunohistochemistry </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-4" data-title="Detection of Mouse TIM-3 by Immunohistochemistry" data-footer="Detection of Mouse TIM-3 by Immunohistochemistry" title="Cat. No. AF1529 - Detection of Mouse TIM-3 by Immunohistochemistry" href="https://resources.rndsystems.com/images/datasheets/af1529_mouse-tim-3-affinity-purified-polyclonal-ab-41202412402532.jpg"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/af1529_mouse-tim-3-affinity-purified-polyclonal-ab-41202412402532.jpg" class="img-fluid" alt="Detection of Mouse TIM-3 by Immunohistochemistry" title="Detection of Mouse TIM-3 by Immunohistochemistry"> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> <span class="data_ex_description_title">Detection of Mouse TIM-3 by Immunohistochemistry</span> Blocking TIM-3 significantly reduces brain injury after hypoxia-ischaemia.(a) Representative images of TTC-stained brain slices from H/I mice treated with 100 μg of IgG (n=12) or anti-TIM-3 antibody (n=12). The infarct volume was quantified with Image J analyser and expressed as a percentage of the damaged ipsilateral hemisphere. (b) Representative magnetic resonance images (MRIs) from TIM-3-antibody-treated mice (n=4) and IgG-treated mice (n=4) at 24 h post-H/I. (c) Representative T2 images from TIM-3-antibody-treated mice (n=4) and IgG-treated mice (n=4) after H/I. (d) The extent of the oedema formation was obtained from the T2-weighted MRI images and ADC map. (e) Representative confocal microscopic images of immunohistochemical staining for NeuN and cleaved caspase-3 in coronal brain sections from IgG- and anti-TIM-3-treated H/I mice 24 h after injury. Scale bar, 50 μm. The graph shows the mean number of NeuN and cleaved caspase-3-stained cells per mm2. (f) Immunoblot detection of full-length PARP proteins in contralateral and ipsilateral cortex regions of control IgG- or anti-TIM-3-treated mice. The graph shows the relative levels of full-length PARP (116 kDa). Data represent the mean±s.d. from at least three independent experiments. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/25790768), licensed under a CC-BY license. Not internally tested by R&D Systems. </p> </div> </div> </div> </div> </div> <div id="ds_calculator" class="datasheet_section"> <div id="btn_calculator_wrapper"><div class="datasheet_calculator_toggle btn btn-secondary" id="btn_reconstitution">Reconstitution Calculator</div></div><div id="datasheet_calculators"><div id="btn_reconstitution_calc" class="datasheet_calculator"><h2>Reconstitution Calculator</h2><div id="reconstitution_calculator" class="calculator"> <form id="recCalc"> <div class="reconstitution_calculator_text" id="reconstitution_calculator_instructions"> <p>The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.</p> </div> <div class="calc_section"> <label for="reconstitution_calculator_volume" class="calculator_label">Volume (to add to vial)</label> <input id="reconstitution_calculator_volume" name="reconstitution_calculator_volume" type="text" maxlength="16" placeholder="volume" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_volume_unit" class="calculator_input calculator_select"> <option value="ml">ml</option> <option value="ul" selected="selected">ul</option> </select> </span> </div> <span class="calculator_equals calculator_operator">=</span> <div class="calc_section"> <label for="reconstitution_calculator_mass" class="calculator_label">Mass (in vial)</label> <input id="reconstitution_calculator_mass" name="reconstitution_calculator_mass" type="text" maxlength="16" placeholder="mass" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_mass_unit" class="calculator_input calculator_select"> <option value="mg">mg</option> <option value="ug" selected="selected">ug</option> <option value="ng">ng</option> </select> </span> </div> <span class="calculator_divide calculator_operator">÷</span> <div class="calc_section"> <label for="reconstitution_calculator_concentration" class="calculator_label">Desired Reconstitution Concentration</label> <input id="reconstitution_calculator_concentration" name="reconstitution_calculator_concentration" type="text" maxlength="16" placeholder="conc." class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_concentration_unit" class="calculator_input calculator_select"> <option value="mg/ml">mg/ml</option> <option value="ug/ml" selected="selected">ug/ml</option> <option value="ng/ml">ng/ml</option> </select> </span> </div> <div id="reconstitution_foot" class="calc_section"> <input type="submit" value="Calculate" id="button_reconstitution_calculator_calculate" class="calculator_button btn btn-secondary"/> </div> </form> </div> </div></div> </div> <div id="ds_preparation_storage" class="datasheet_section"> <h2>Preparation and Storage</h2> <div class="ds_table prep_table"> <div class="ds_table_body"> <div class="ds_table_row"> <div class="ds_table_cell prep_table_name">Reconstitution</div> <div class="ds_table_cell prep_table_data">Reconstitute at 0.2 mg/mL in sterile PBS. <div id="reconstitution-buffer"> <div id="reconstitution-buffer-placeholder"> <div class="et_spinner_small"></div> Loading... </div> </div> </div> </div> <div class="ds_table_row"> <div class="ds_table_cell prep_table_name">Shipping</div> <div class="ds_table_cell prep_table_data">Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below. </div> </div> <div class="ds_table_row"> <div class="ds_table_cell prep_table_name">Stability & Storage</div> <div class="ds_table_cell prep_table_data"><b>Use a manual defrost freezer and avoid repeated freeze-thaw cycles. </b><UL><LI>12 months from date of receipt, -20 to -70 °C as supplied.</LI><LI>1 month, 2 to 8 °C under sterile conditions after reconstitution.</LI><LI>6 months, -20 to -70 °C under sterile conditions after reconstitution.</LI></UL> </div> </div> </div> </div> </div> <div id="ds_background" class="datasheet_section"> <h2>Background: TIM-3</h2> <p><P>TIM-3 (T cell immunoglobulin and mucin domain-3) is a 60 kDa member of the TIM family of immune regulating molecules. TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk (1-3). There are three TIM genes in human and eight in mouse. Mature mouse TIM-3 consists of a 174 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment (TM), and a 67 aa cytoplasmic tail (4). Two alternately spliced isoforms have been reported in mouse which lack either the TM or both the TM and mucin regions (5, 6). Within the ECD, mouse TIM-3 shares 58% and 74% aa sequence identity with human and rat TIM-3, respectively. TIM-3 is specifically expressed on Th1 cells whereas TIM-1 and TIM-2 are expressed on Th2 cells. In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types and on hippocampal neurons (9-12). The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9 which induces TIM-3 Tyr phosphorylation and proapoptotic signaling (10, 13). TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation, and cytotoxicity (5, 7, 12, 14). TIM-3 may play a role in regulatory T cell development (7), inflammation (15), and immune tolerance (5, 13, 14). Soluble mouse TIM-3 has been shown to inhibit anti-tumor effector T cell responses and to enhance autoimmune reactions (6, 7).</P></p> <div class="ds_table background_table"> <div class="ds_table_body"> <div class="ds_table_row"> <div class="ds_table_cell background_table_name"><a id="reftop"></a>References</div> <div class="ds_table_cell background_table_data"><OL> <LI>Anderson, A.C. and D.E. Anderson (2006) Curr. Opin. Immunol. <STRONG>18</STRONG>:665.</LI> <LI>Mariat, C. <EM>et al</EM>. (2005) Phil. Trans. R. Soc. B <STRONG>360</STRONG>:1681.</LI> <LI>Meyers, J.H. <EM>et al</EM>. (2005) Trends Mol. Med. <STRONG>11</STRONG>:362.</LI> <LI>Monney, L. <EM>et al</EM>. (2002) Nature <STRONG>415</STRONG>:536.</LI> <LI>Sabatos, C.A. <EM>et al</EM>. (2003) Nat. Immunol. <STRONG>4</STRONG>:1102.</LI> <LI>Geng, H. <EM>et al</EM>. (2006) J. Immunol. <STRONG>176</STRONG>:1411.</LI> <LI>Sanchez-Fueyo, A. <EM>et al</EM>. (2003) Nat. Immunol. <STRONG>4</STRONG>:1093.</LI> <LI>Khademi, M. <EM>et al</EM>. (2004) J. Immunol. <STRONG>172</STRONG>:7169.</LI> <LI>Wiener, Z. <EM>et al</EM>. (2007) J. Invest. Dermatol. <STRONG>127</STRONG>:906.</LI> <LI>van de Weyer, P.S. <EM>et al</EM>. (2006) Biochem. Biophys. Res. Commun. <STRONG>351</STRONG>:571.</LI> <LI>Gielen, A.W. <EM>et al</EM>. (2005) J. Neuroimmunol. <STRONG>164</STRONG>:93.</LI> <LI>Oikawa, T. <EM>et al</EM>. (2006) J. Immunol. <STRONG>177</STRONG>:4281.</LI> <LI>Zhu, C. <EM>et al</EM>. (2005) Nat. Immunol. <STRONG>6</STRONG>:1245.</LI> <LI>Koguchi, K. <EM>et al</EM>. (2006) J. Exp. Med. <STRONG>203</STRONG>:1413.</LI> <LI>Frisancho-Kiss, S. <EM>et al.</EM> (2006) J. Immunol.<STRONG> 176:</STRONG>6411. </LI></OL></div> </div> <div class="ds_table_row"> <div class="ds_table_cell background_table_name">Long Name</div> <div class="ds_table_cell background_table_data">T Cell Immunoglobulin Mucin-3</div> </div> <div class="ds_table_row"> <div class="ds_table_cell background_table_name">Entrez Gene IDs</div> <div class="ds_table_cell background_table_data">84868 (Human); 171285 (Mouse); 363578 (Rat); 479318 (Canine); 102141722 (Cynomolgus Monkey)</div> </div> <div class="ds_table_row"> <div class="ds_table_cell background_table_name">Alternate Names</div> <div class="ds_table_cell background_table_data">CD366; FLJ14428; HAVCR2; HAVcr-2; hepatitis A virus cellular receptor 2; kidney injury molecule-3; KIM-3; SPTCL; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain-containing protein 3; TIM 3; TIM3 T-cell membrane protein 3; TIM3; TIM-3; TIMD3; TIMD-3; TIMD3KIM-3</div> </div> </div> </div> </div> <div class="datasheet_section" id="product-datasheets"> <h2 id="ds_datasheets">Product Datasheets</h2> <div class="product_datasheets"> <span class="sds-message hide"> <p class="sds-label">You must select a language.</p> <span class="close_sds_message">x</span> </span> <div class="ds_document"> <a id="cfpdf" href="//resources.rndsystems.com/pdfs/datasheets/af1529.pdf?v=20241123" class="datasheets-link " target="_blank" rel="noreferrer nofollow">Product Datasheet</a> </div> <div class="ds_document"> <div class="ds_pdfData"><a class="datasheets-link" href="https://www.rndsystems.com/cofas/mouse-tim-3-antibody_af1529">COA</a> </div> </div> <div class="ds_document sds_link"> <a class="sds_non_cf datasheets-link non_cf_download_link" target="_blank" rel="noreferrer" data-path="//aero.bio-techne.com/sds/pdf/af1529?v=20241123">SDS</a> </div> </div> </div> <div id="ds_related_research_areas" class="datasheet_section"> <h2>Related Research Areas</h2> <ul class="ds_details"> <li> <a href="/research-area/acute-myeloid-leukemia">Acute Myeloid Leukemia</a> </li> <li> <a href="/research-area/cancer-stem-cell-markers">Cancer Stem Cell Markers</a> </li> <li> <a href="/research-area/co--stimulatory-and-co--inhibitory-molecules">Co-stimulatory and Co-inhibitory Molecules</a> </li> <li> <a href="/research-area/infectious-diseases">Infectious Diseases</a> </li> <li> <a href="/research-area/search-immune-checkpoint-targets">Search Immune Checkpoint Targets</a> </li> <li> <a href="/research-area/special-glycoproteins">Special Glycoproteins</a> </li> </ul> </div> </div> <div class="tab_content tab_3" data-tab="3" data-tabname="product-citations" id="citations"> <a id="citations_section"></a> <h2><span class="citations">Citations for Mouse TIM-3 Antibody</h2> <div id="citation"> <a id="dsTabCitations"></a> <p> R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. </p> <p> <strong><span id="maxcitations">4</span> Citations: Showing <span id="showfrom">1</span> - <span id="showto">4</span> </strong> <br/><strong>Filter your results:</strong> </p> <div class="row"> <div class="col-sm-12"> <div class="citations_filters"> <p style="display:inline;"><b>Filter by:</b></p> <div class="select_wrapper filter_select"> <select id="selSpecies" title="Species"> <option value="All">All Species</option> <option class="citation_filterRadio" value="species" data-filter="Mouse"> Mouse </option> </select> </div> <div class="select_wrapper filter_select"> <select id="selAntibody" title="Applications"> <option value="All">All Applications</option> <option class="citation_filterRadio" value="application" data-filter="ICC"> ICC </option> <option class="citation_filterRadio" value="application" data-filter="IHC"> IHC </option> <option class="citation_filterRadio" value="application" data-filter="Western Blot"> Western Blot </option> </select> </div> <div class="select_wrapper filter_select"> <select id="selSampleType" title="Sample Types"> <option value="All">All Sample Types</option> <option class="citation_filterRadio" value="sampletype" data-filter="Cell Lysates"> Cell Lysates </option> <option class="citation_filterRadio" value="sampletype" data-filter="Whole Cells"> Whole Cells </option> <option class="citation_filterRadio" value="sampletype" data-filter="Whole Tissue"> Whole Tissue </option> </select> </div> </div> </div> </div> <div class="row"> <ol id="citations" class="col-xs-12" data-expandall="false" data-max-citations="4" data-max-show="10"> <li class="top-lined" data-species="Mouse" data-application="IHC" data-sampletype="Whole Tissue"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/31018140"> Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis </a> </span><br/> Authors: E Wingrove, ZZ Liu, KD Patel, A Arnal-Esta, WL Cai, MA Melnick, K Politi, C Monteiro, L Zhu, M Valiente, HM Kluger, VL Chiang, DX Nguyen<br/> Cell Rep, 2019-04-23;27(4):1277-1292.e7.<br/> Species: Mouse<br/> Sample Types: Whole Tissue<br/> Applications: IHC </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28253997"> CB2 cannabinoid receptors modulate HIF-1 alpha and TIM-3 expression in a hypoxia-ischemia mouse model </a> </span><br/> Authors: Elk Kossatz, Rafael Maldonado, Patricia Robledo<br/> European Neuropsychopharmacology<br/> </li> <li class="top-lined" data-species="Mouse" data-application="ICC" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/25790768"> The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia. </a> </span><br/> Authors: Koh H, Chang C, Jeon S, Yoon H, Ahn Y, Kim H, Kim I, Jeon S, Johnson R, Park E<br/> Nat Commun, 2015-03-20;6(0):6340.<br/> Species: Mouse<br/> Sample Types: Whole Cells<br/> Applications: ICC </li> <li class="top-lined" data-species="Mouse" data-application="Western Blot" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/17620455"> TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells. </a> </span><br/> Authors: Nakae S, Iikura M, Suto H, Akiba H, Umetsu DT, DeKruyff RH, Saito H, Galli SJ<br/> Blood, 2007-07-09;110(7):2565-8.<br/> Species: Mouse<br/> Sample Types: Cell Lysates<br/> Applications: Western Blot </li> </ol> </div> </div> </div> <div class="tab_content tab_4" data-tab="4" data-tabname="product-faqs" id="product-faqs"> <h2>FAQs</h2> <div class="row"> <div class="col-xs-12"> <p>No product specific FAQs exist for this product, however you may</p> <a class="btn btn-quinary view_all_faqs_btn" href="/resources/faqs/primary-antibodies"> View all Antibody FAQs </a> </div> </div> </div> <div class="tab_content tab_5" data-tab="5" data-tabname="product-supplemental" id="supplemental-products"> <div id="supplemental-products-tab-content-placeholder" class="tab-content-placeholder" data-id="supplemental-products" data-catalog_number="af1529" data-language="en"> <div class="et_spinner_small"></div> Loading... </div> </div> <div class="tab_content tab_6" data-tab="6" data-tabname="product-reviews" id="reviews"> <h3>Reviews for Mouse TIM-3 Antibody</h3> <div class="row"> <div class="col-xs-12"> <div> <div class="row"> <div class="col-md-6"> <p>There are currently no reviews for this product. 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Mouse TIM-3 Antibody AF1529: R&D Systems