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Benouaret</title> <meta name="description" content="Search results for: Zina Benouaret"> <meta name="keywords" content="Zina Benouaret"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Zina Benouaret"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 10</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Zina Benouaret</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> Performance of the Strong Stability Method in the Univariate Classical Risk Model</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Safia%20Hocine">Safia Hocine</a>, <a href="https://publications.waset.org/abstracts/search?q=Zina%20Benouaret"> Zina Benouaret</a>, <a href="https://publications.waset.org/abstracts/search?q=Djamil%20A%C2%A8%C4%B1ssani"> Djamil A¨ıssani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper, we study the performance of the strong stability method of the univariate classical risk model. We interest to the stability bounds established using two approaches. The first based on the strong stability method developed for a general Markov chains. The second approach based on the regenerative processes theory . By adopting an algorithmic procedure, we study the performance of the stability method in the case of exponential distribution claim amounts. After presenting numerically and graphically the stability bounds, an interpretation and comparison of the results have been done. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Marcov%20chain" title="Marcov chain">Marcov chain</a>, <a href="https://publications.waset.org/abstracts/search?q=regenerative%20process" title=" regenerative process"> regenerative process</a>, <a href="https://publications.waset.org/abstracts/search?q=risk%20model" title=" risk model"> risk model</a>, <a href="https://publications.waset.org/abstracts/search?q=ruin%20probability" title=" ruin probability"> ruin probability</a>, <a href="https://publications.waset.org/abstracts/search?q=strong%20stability" title=" strong stability"> strong stability</a> </p> <a href="https://publications.waset.org/abstracts/89002/performance-of-the-strong-stability-method-in-the-univariate-classical-risk-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/89002.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">324</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> Stability Bound of Ruin Probability in a Reduced Two-Dimensional Risk Model</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zina%20Benouaret">Zina Benouaret</a>, <a href="https://publications.waset.org/abstracts/search?q=Djamil%20Aissani"> Djamil Aissani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this work, we introduce the qualitative and quantitative concept of the strong stability method in the risk process modeling two lines of business of the same insurance company or an insurance and re-insurance companies that divide between them both claims and premiums with a certain proportion. The approach proposed is based on the identification of the ruin probability associate to the model considered, with a stationary distribution of a Markov random process called a reversed process. Our objective, after clarifying the condition and the perturbation domain of parameters, is to obtain the stability inequality of the ruin probability which is applied to estimate the approximation error of a model with disturbance parameters by the considered model. In the stability bound obtained, all constants are explicitly written. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Markov%20chain" title="Markov chain">Markov chain</a>, <a href="https://publications.waset.org/abstracts/search?q=risk%20models" title=" risk models"> risk models</a>, <a href="https://publications.waset.org/abstracts/search?q=ruin%20probabilities" title=" ruin probabilities"> ruin probabilities</a>, <a href="https://publications.waset.org/abstracts/search?q=strong%20stability%20analysis" title=" strong stability analysis"> strong stability analysis</a> </p> <a href="https://publications.waset.org/abstracts/85274/stability-bound-of-ruin-probability-in-a-reduced-two-dimensional-risk-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85274.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">249</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> 3D CFD Modelling of the Airflow and Heat Transfer in Cold Room Filled with Dates </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zina%20Ghiloufi">Zina Ghiloufi</a>, <a href="https://publications.waset.org/abstracts/search?q=Tahar%20Khir"> Tahar Khir</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A transient three-dimensional computational fluid dynamics (CFD) model is developed to determine the velocity and temperature distribution in different positions cold room during pre-cooling of dates. The turbulence model used is the k-ω Shear Stress Transport (SST) with the standard wall function, the air. The numerical results obtained show that cooling rate is not uniform inside the room; the product at the medium of room has a slower cooling rate. This cooling heterogeneity has a large effect on the energy consumption during cold storage. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=CFD" title="CFD">CFD</a>, <a href="https://publications.waset.org/abstracts/search?q=cold%20room" title=" cold room"> cold room</a>, <a href="https://publications.waset.org/abstracts/search?q=cooling%20rate" title=" cooling rate"> cooling rate</a>, <a href="https://publications.waset.org/abstracts/search?q=dDates" title=" dDates"> dDates</a>, <a href="https://publications.waset.org/abstracts/search?q=numerical%20simulation" title=" numerical simulation"> numerical simulation</a>, <a href="https://publications.waset.org/abstracts/search?q=k-%CF%89%20%28SST%29" title=" k-ω (SST)"> k-ω (SST)</a> </p> <a href="https://publications.waset.org/abstracts/90986/3d-cfd-modelling-of-the-airflow-and-heat-transfer-in-cold-room-filled-with-dates" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/90986.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">235</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Practical Simulation Model of Floating-Gate MOS Transistor in Sub 100 nm Technologies</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zina%20Saheb">Zina Saheb</a>, <a href="https://publications.waset.org/abstracts/search?q=Ezz%20El-Masry"> Ezz El-Masry</a> </p> <p class="card-text"><strong>Abstract:</strong></p> As CMOS technology scaling down, Silicon oxide thickness (SiO2) become very thin (few Nano meters). When SiO2 is less than 3nm, gate direct tunneling (DT) leakage current becomes a dormant problem that impacts the transistor performance. Floating gate MOSFET (FGMOSFET) has been used in many low-voltage and low-power applications. Most of the available simulation models of FGMOSFET for analog circuit design does not account for gate DT current and there is no accurate analysis for the gate DT. It is a crucial to use an accurate mode in order to get a realistic simulation result that account for that DT impact on FGMOSFET performance effectively. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=CMOS%20transistor" title="CMOS transistor">CMOS transistor</a>, <a href="https://publications.waset.org/abstracts/search?q=direct-tunneling%20current" title=" direct-tunneling current"> direct-tunneling current</a>, <a href="https://publications.waset.org/abstracts/search?q=floating-gate" title=" floating-gate"> floating-gate</a>, <a href="https://publications.waset.org/abstracts/search?q=gate-leakage%20current" title=" gate-leakage current"> gate-leakage current</a>, <a href="https://publications.waset.org/abstracts/search?q=simulation%20model" title=" simulation model"> simulation model</a> </p> <a href="https://publications.waset.org/abstracts/30655/practical-simulation-model-of-floating-gate-mos-transistor-in-sub-100-nm-technologies" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/30655.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">529</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Analysis and Design of Simultaneous Dual Band Harvesting System with Enhanced Efficiency</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zina%20Saheb">Zina Saheb</a>, <a href="https://publications.waset.org/abstracts/search?q=Ezz%20El-Masry"> Ezz El-Masry</a>, <a href="https://publications.waset.org/abstracts/search?q=Jean-Fran%C3%A7ois%20Bousquet"> Jean-François Bousquet</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper presents an enhanced efficiency simultaneous dual band energy harvesting system for wireless body area network. A bulk biasing is used to enhance the efficiency of the adapted rectifier design to reduce V<sub>th</sub> of MOSFET. The presented circuit harvests the radio frequency (RF) energy from two frequency bands: 1 GHz and 2.4 GHz. It is designed with TSMC 65-nm CMOS technology and high quality factor dual matching network to boost the input voltage. Full circuit analysis and modeling is demonstrated. The simulation results demonstrate a harvester with an efficiency of 23% at 1 GHz and 46% at 2.4 GHz at an input power as low as -30 dBm. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=energy%20harvester" title="energy harvester">energy harvester</a>, <a href="https://publications.waset.org/abstracts/search?q=simultaneous" title=" simultaneous"> simultaneous</a>, <a href="https://publications.waset.org/abstracts/search?q=dual%20band" title=" dual band"> dual band</a>, <a href="https://publications.waset.org/abstracts/search?q=CMOS" title=" CMOS"> CMOS</a>, <a href="https://publications.waset.org/abstracts/search?q=differential%20rectifier" title=" differential rectifier"> differential rectifier</a>, <a href="https://publications.waset.org/abstracts/search?q=voltage%20boosting" title=" voltage boosting"> voltage boosting</a>, <a href="https://publications.waset.org/abstracts/search?q=TSMC%2065nm" title=" TSMC 65nm"> TSMC 65nm</a> </p> <a href="https://publications.waset.org/abstracts/47076/analysis-and-design-of-simultaneous-dual-band-harvesting-system-with-enhanced-efficiency" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/47076.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">404</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Agronomic Value of Wastewater and Sugar Beet Lime Sludge Compost on Radish Crop</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20Rida">S. Rida</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20Saadani%20Hassani"> O. Saadani Hassani</a>, <a href="https://publications.waset.org/abstracts/search?q=Q.%20R%E2%80%99zina"> Q. R’zina</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20Saadaoui"> N. Saadaoui</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20Fares"> K. Fares</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Wastewater treatment stations create large quantities of sludge, whose treatment is poorly underestimated in the draft installation. However, chemical analysis of sludge reveals their important concentration in fertilizer elements including nitrogen and phosphorus. The direct application of sludge can reveal contamination of the food chain because of their chemical and organic micropollutants load. Therefore, there is a need of treatment process before use. The treatment by composting of this sludge mixed with three different proportions of sugar beet lime sludge (0%, 20%,30%) and green waste permits to obtain a stable compost rich in mineral elements, having a pleasant smell and relatively hygienic. In addition, the use of compost in agriculture positively affects the plant-soil system. Thus, this study shows that the supply of compost improves the physical properties of the soil and its agronomic quality, which results in an increase in the biomass of cultivated radish plants and a larger crop. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=agriculture" title="agriculture">agriculture</a>, <a href="https://publications.waset.org/abstracts/search?q=composting" title=" composting"> composting</a>, <a href="https://publications.waset.org/abstracts/search?q=soil" title=" soil"> soil</a>, <a href="https://publications.waset.org/abstracts/search?q=sugar%20beet%20lime" title=" sugar beet lime"> sugar beet lime</a>, <a href="https://publications.waset.org/abstracts/search?q=wastewater" title=" wastewater"> wastewater</a> </p> <a href="https://publications.waset.org/abstracts/42132/agronomic-value-of-wastewater-and-sugar-beet-lime-sludge-compost-on-radish-crop" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/42132.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">323</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Legal Study about Flagellation Punishment of Qanun Jinayah in Aceh Province</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yuyun%20Sri%20Wahyuni">Yuyun Sri Wahyuni</a>, <a href="https://publications.waset.org/abstracts/search?q=Fathih%20Misbahuddin%20Islam"> Fathih Misbahuddin Islam</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nanggroe Aceh Darussalam is the special district with its long conflict history. The long conflict history started from The Free Aceh Movement’s intentions to implement Islamic principles in Aceh Province, it was actually contradicted with the principles of state. This long conflict was finally ended on 2005. Then, since 2005 Aceh had special authority to administer its local government affairs by applying Islamic principles (syariah), included criminal law matters. To administer it, Aceh Government enacted Law Number 6 of 2014 on the Jinayah. This law consists the criminal act (jarimah) and the punishment (uqubat). Khamr, maisir, khalwat, ikhtilath, zina, sexual harrasment, rape, qadzaf, liwath, and musahaqah are the kinds of the criminal act which are ruled within. Meanwhile, Hudud and Takdzir as the kinds of punishment (uqubat). After 2 years of the issuance of this law inflicting controversy from any sides and being discussed not only locally but also globally. The objectives of this paper are to analyze the fundamental value of the flagellation punishment within this law and Aceh Government review in formulating the law. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Aceh%20province" title="Aceh province">Aceh province</a>, <a href="https://publications.waset.org/abstracts/search?q=flagellation%20punishment" title=" flagellation punishment"> flagellation punishment</a>, <a href="https://publications.waset.org/abstracts/search?q=Islamic%20Principle" title=" Islamic Principle"> Islamic Principle</a>, <a href="https://publications.waset.org/abstracts/search?q=Qanun%20Jinayah" title=" Qanun Jinayah"> Qanun Jinayah</a> </p> <a href="https://publications.waset.org/abstracts/67548/legal-study-about-flagellation-punishment-of-qanun-jinayah-in-aceh-province" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/67548.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">228</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Seasons and Saproxylic Beetles Biodiversity in an Urban Park in Tunisia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zina%20Nasr">Zina Nasr</a>, <a href="https://publications.waset.org/abstracts/search?q=Faiek%20Errouissi"> Faiek Errouissi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Forest ecosystems are known for its ability to contain a large diversity of fauna especially insects that represent a huge taxonomic group. A portion of forest insects are recognized as saproxylic including the group of organisms that ‘depend on dead or dying wood’ about them, 20% are beetles. We focused our study on saproxylic beetles in an old urban park ‘the park of Belvedere’, located in the north west of Tunis (36° 49'21’ N 10°10'24’ W). The vegetation is dominated by old trees (Eucalyptus, Olea, Aberia, Pinus) and many fallen wood exist. Saproxylic beetles were collected using three interception traps set in the park over one year (from June 2014 to May 2015) and recovered monthly. In total, we collected 189 beetles belonging to 20 families and 57 species. Several saproxylic families (Bostrichidae, Cerambycidae, Curculionidae, Melyridae, Nitidulidae, Staphylinidae), and well known genus (Rhizopertha, Thrychoplerus, Otiorhychus, Dolichosoma, Epuraea, Anotylus) are recorded. We have retained the largest activity of beetles in spring and a very low richness in winter with zero insect per traps. This result was certainly caused by the variation of meteorological factors that mainly influenced the activity of these organisms. Therefore, we were interested on the saproxylic diversity in an urban ‘forest’, and these results will be more interesting when they are compared in the future with other works from natural forest. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=saproxylic%20beetles" title="saproxylic beetles">saproxylic beetles</a>, <a href="https://publications.waset.org/abstracts/search?q=seasons" title=" seasons"> seasons</a>, <a href="https://publications.waset.org/abstracts/search?q=urban%20park" title=" urban park"> urban park</a>, <a href="https://publications.waset.org/abstracts/search?q=wood" title=" wood"> wood</a> </p> <a href="https://publications.waset.org/abstracts/67561/seasons-and-saproxylic-beetles-biodiversity-in-an-urban-park-in-tunisia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/67561.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">344</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Access to Natural Resources in the Cameroonian Part of the Logone Basin: A Driver and Mitigation Tool to Ethnical Conflicts</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bonguen%20Onouck%20Rolande%20Carole">Bonguen Onouck Rolande Carole</a>, <a href="https://publications.waset.org/abstracts/search?q=Ndongo%20Barthelemy"> Ndongo Barthelemy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The climate change effects on the Lake Chad, coupled with population growth, have pushed large masses of people of various origins towards the lower part of the lower Logonewatershed in search of the benefits of environmental services, causing pressure on the environment and its resources. Economic services are therefore threatened, and the decrease in resources contributes to the deterioration of the social wellbeing resulting to conflicts among/between local communities, immigrants, displaced people, and foreigners. This paper is an information contribution on ethnical conflicts drivers in the area and the provided local management mechanisms such can help mitigate present or future conflicts in similar areas. It also prints out the necessity to alleviate water access deficit and encourage good practices for the population wellbeing. In order to meet the objective, in 2018, through the interface of the World Bank-Cameroon project-PULCI, data were collected on the field directly by discussing with the population and visiting infrastructures, indirectly by a questionnaire survey. Two administrative divisions were chosen (Logoneet Chari, Mayo-Danay) in which targeted localities were Zina, Mazera, Lahai, Andirni near the Waza Park and Yagoua, Tekele, Pouss, respectively. Due to some sociocultural and religious reasons, some information were acquired through the traditional chiefs. A desk study analysis based on resources access and availability conflicts history, and management mechanism was done. As results, roots drivers of ethnical conflicts are struggles over natural resources access, and the possibility of conflicts increases as the scarcity and vulnerabilities persist, creating more sociocultural gaps and tensions. The mitigation mechanisms though fruitful, are limited. There is poor documentation on the topic, the resources management policies of this basin are unsuitable and ineffective for some. Therefore, the restoration of environmental and ecosystems, the mitigation of climate change effects, and food insecurity are the challenges that must be met to alleviate conflicts in these localities. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ethnic" title="ethnic">ethnic</a>, <a href="https://publications.waset.org/abstracts/search?q=communities" title=" communities"> communities</a>, <a href="https://publications.waset.org/abstracts/search?q=conflicts" title=" conflicts"> conflicts</a>, <a href="https://publications.waset.org/abstracts/search?q=mitigation%20mechanisms" title=" mitigation mechanisms"> mitigation mechanisms</a>, <a href="https://publications.waset.org/abstracts/search?q=natural%20resources" title=" natural resources"> natural resources</a>, <a href="https://publications.waset.org/abstracts/search?q=logone%20basin" title=" logone basin"> logone basin</a> </p> <a href="https://publications.waset.org/abstracts/150540/access-to-natural-resources-in-the-cameroonian-part-of-the-logone-basin-a-driver-and-mitigation-tool-to-ethnical-conflicts" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/150540.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">111</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Clinical and Analytical Performance of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase L1 Biomarkers for Traumatic Brain Injury in the Alinity Traumatic Brain Injury Test</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Raj%20Chandran">Raj Chandran</a>, <a href="https://publications.waset.org/abstracts/search?q=Saul%20Datwyler"> Saul Datwyler</a>, <a href="https://publications.waset.org/abstracts/search?q=Jaime%20Marino"> Jaime Marino</a>, <a href="https://publications.waset.org/abstracts/search?q=Daniel%20West"> Daniel West</a>, <a href="https://publications.waset.org/abstracts/search?q=Karla%20Grasso"> Karla Grasso</a>, <a href="https://publications.waset.org/abstracts/search?q=Adam%20Buss"> Adam Buss</a>, <a href="https://publications.waset.org/abstracts/search?q=Hina%20Syed"> Hina Syed</a>, <a href="https://publications.waset.org/abstracts/search?q=Zina%20Al%20Sahouri"> Zina Al Sahouri</a>, <a href="https://publications.waset.org/abstracts/search?q=Jennifer%20Yen"> Jennifer Yen</a>, <a href="https://publications.waset.org/abstracts/search?q=Krista%20Caudle"> Krista Caudle</a>, <a href="https://publications.waset.org/abstracts/search?q=Beth%20McQuiston"> Beth McQuiston</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The Alinity i TBI test is Therapeutic Goods Administration (TGA) registered and is a panel of in vitro diagnostic chemiluminescent microparticle immunoassays for the measurement of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) in plasma and serum. The Alinity i TBI performance was evaluated in a multi-center pivotal study to demonstrate the capability to assist in determining the need for a CT scan of the head in adult subjects (age 18+) presenting with suspected mild TBI (traumatic brain injury) with a Glasgow Coma Scale score of 13 to 15. TBI has been recognized as an important cause of death and disability and is a growing public health problem. An estimated 69 million people globally experience a TBI annually1. Blood-based biomarkers such as glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) have shown utility to predict acute traumatic intracranial injury on head CT scans after TBI. A pivotal study using prospectively collected archived (frozen) plasma specimens was conducted to establish the clinical performance of the TBI test on the Alinity i system. The specimens were originally collected in a prospective, multi-center clinical study. Testing of the specimens was performed at three clinical sites in the United States. Performance characteristics such as detection limits, imprecision, linearity, measuring interval, expected values, and interferences were established following Clinical and Laboratory Standards Institute (CLSI) guidance. Of the 1899 mild TBI subjects, 120 had positive head CT scan results; 116 of the 120 specimens had a positive TBI interpretation (Sensitivity 96.7%; 95% CI: 91.7%, 98.7%). Of the 1779 subjects with negative CT scan results, 713 had a negative TBI interpretation (Specificity 40.1%; 95% CI: 37.8, 42.4). The negative predictive value (NPV) of the test was 99.4% (713/717, 95% CI: 98.6%, 99.8%). The analytical measuring interval (AMI) extends from the limit of quantitation (LoQ) to the upper LoQ and is determined by the range that demonstrates acceptable performance for linearity, imprecision, and bias. The AMI is 6.1 to 42,000 pg/mL for GFAP and 26.3 to 25,000 pg/mL for UCH-L1. Overall, within-laboratory imprecision (20 day) ranged from 3.7 to 5.9% CV for GFAP and 3.0 to 6.0% CV for UCH-L1, when including lot and instrument variances. The Alinity i TBI clinical performance results demonstrated high sensitivity and high NPV, supporting the utility to assist in determining the need for a head CT scan in subjects presenting to the emergency department with suspected mild TBI. The GFAP and UCH-L1 assays show robust analytical performance across a broad concentration range of GFAP and UCH-L1 and may serve as a valuable tool to help evaluate TBI patients across the spectrum of mild to severe injury. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biomarker" title="biomarker">biomarker</a>, <a href="https://publications.waset.org/abstracts/search?q=diagnostic" title=" diagnostic"> diagnostic</a>, <a href="https://publications.waset.org/abstracts/search?q=neurology" title=" neurology"> neurology</a>, <a href="https://publications.waset.org/abstracts/search?q=TBI" title=" TBI"> TBI</a> </p> <a href="https://publications.waset.org/abstracts/177550/clinical-and-analytical-performance-of-glial-fibrillary-acidic-protein-and-ubiquitin-c-terminal-hydrolase-l1-biomarkers-for-traumatic-brain-injury-in-the-alinity-traumatic-brain-injury-test" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/177550.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">66</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); 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