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Keeping Up with COVID - Exel: Drexel University's Research Magazine
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method="get" action="https://exelmagazine.org/" style="margin: 0; padding: 0;"> <input id="quick-search" name="s" placeholder="Search" type="text" /> <span class="quick-search-icon icon-thin-search" onclick="jQuery('#qsearchform').submit();"></span> </form> </div> </nav> </div> </div> </header> <!-- end header --> <div id="top-pad"> </div> <div class="white-section story-section article-news"> <div class="exel-x"> <div class="exel-x-image"> </div> <h3>2023<br/><span class="article-department">_PUBLIC HEALTH</span> Machine Learning</h3> </div> <div class="row-fluid news-header"> <h2 class="news-title">_Keeping Up with COVID</h2><div class="news-excerpt">Drexel is using machine learning to spot the rise of dangerous COVID variants that may emerge in the future. <span class="article-byline"></span></div> </div> <!-- Main Section --> <div class="row-fluid row-main"> <div class="article-content"> <div class="article-researcher"><div class="article-researcher-image"><img src="https://exelmagazine.org/wp-content/uploads/2023/06/Bahrad-Sokhansanj.png" alt="" /></div><h3>_Bahrad A. Sokhansanj</h3><p>Sokhansanj is an assistant research professor in the College of Engineering.</p></div> <div class="article-content-inner"> <p>Drexel researchers hope to be among the first to spot the signs of the next dangerous COVID variant, thanks to a computer model developed in the College of Engineering.</p> <p>The model uses <a href="https://drexel.edu/news/archive/2022/August/machine-learning-covid-sequencing-projecting-severity-of-new-variants">machine learning algorithms</a> trained to identify correlations between changes in the genetic sequence of the COVID-19 virus and upticks in transmission, hospitalizations and deaths.</p> <p><a href="https://www.sciencedirect.com/science/article/pii/S0010482522006990">The program</a> can quickly hone in on the areas of the genetic sequence that are most likely to be linked to changes in the severity of the variant.</p> <blockquote><p> <img decoding="async" src="https://exelmagazine.org/wp-content/uploads/2023/06/EXEL2023_Web_sidebars_KeepingUpWithCovid.jpg" /></p> <h3></h3> <h4>Some estimates suggest that SARS-CoV-2 has only explored as little as 30–40% of the potential space for spike mutations.</h4> </blockquote> <p>“Our model is more like an early warning system for emerging variants,” says Bahrad A. Sokhansanj, an assistant research professor who led development of the computer model. “When we get a sequence, we can make a prediction about risk of severe disease from a variant before labs run experiments with animal models or cell culture, or before enough people get sick that you can collect epidemiological data.”</p> <p>Genetic and patient data from the GISAID database — the largest compendium of information on people who have been infected with the coronavirus — were used to train the algorithm.</p> <p>“Some estimates suggest that SARS-CoV-2 has only explored as little as 30–40% of the potential space for spike mutations,” says Gail Rosen, a professor in the College of Engineering who heads Drexel’s Ecological and Evolutionary Signal-processing and Informatics Laboratory. </p> <p>“When you consider that each mutation could impact key virus properties, like virulence and immune evasion, it seems vital to be able to quickly identify these variations and understand what they mean for those who are vulnerable to infection,” she says.</p> <div class="social-button-container"> <a target="_blank" href="http://www.facebook.com/sharer.php?u=https://exelmagazine.org/article/keeping-up-with-covid/&t=Keeping Up with COVID"><span class="icon icon-facebook-sign"></span></a> <a target="_blank" href="http://twitter.com/home?status=Currently%20reading%3A%20%40DrexelUniv%27s%20EXEL%20Magazine%20https%3A%2F%2Fexelmagazine.org%2Farticle%2Fkeeping-up-with-covid%2F" title="Click to share this post on Twitter"><span class="icon icon-twitter-sign"></span></a> </div> </div> </div> </div> <!-- end row --> </div> <script type="text/javascript">;(function(window, document, undefined, $) {$(document).ready(function(){ $('h6').fitText('.3');$(".article-content-inner p:nth-child(1)").initialLetter({ initialLetter: "dropped" });var exel_paras = 1; 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