Grape Seed Extract in Prevention and Treatment of Liver Toxic Cirrhosis in Rats

<!DOCTYPE html> <html lang="en" dir="ltr"> <head>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-P63WKM1TM1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-P63WKM1TM1'); </script>  <script type="text/javascript" > (function(m,e,t,r,i,k,a){m[i]=m[i]||function(){(m[i].a=m[i].a||[]).push(arguments)}; m[i].l=1*new Date(); for (var j = 0; j < document.scripts.length; j++) {if (document.scripts[j].src === r) { return; }} k=e.createElement(t),a=e.getElementsByTagName(t)[0],k.async=1,k.src=r,a.parentNode.insertBefore(k,a)}) (window, document, "script", "https://mc.yandex.ru/metrika/tag.js", "ym"); ym(55165297, "init", { clickmap:false, trackLinks:true, accurateTrackBounce:true, webvisor:false }); </script> <noscript><div><img src="https://mc.yandex.ru/watch/55165297" style="position:absolute; left:-9999px;" alt="" /></div></noscript>    <title>Grape Seed Extract in Prevention and Treatment of Liver Toxic Cirrhosis in Rats</title> <meta name="description" content="Grape Seed Extract in Prevention and Treatment of Liver Toxic Cirrhosis in Rats"> <meta name="keywords" content="Carbon tetrachloride, GSE, liver cirrhosis, prevention, treatment."> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <meta name="citation_title" content="Grape Seed Extract in Prevention and Treatment of Liver Toxic Cirrhosis in Rats"> <meta name="citation_author" content="S. Buloyan"> <meta name="citation_author" content="V. Mamikonyan"> <meta name="citation_author" content="H. Hakobyan"> <meta name="citation_author" content="H. Harutyunyan"> <meta name="citation_author" content="H. Gasparyan"> <meta name="citation_publication_date" content="2014/11/04"> <meta name="citation_journal_title" content="International Journal of Pharmacological and Pharmaceutical Sciences"> <meta name="citation_volume" content="8"> <meta name="citation_issue" content="12"> <meta name="citation_firstpage" content="1362"> <meta name="citation_lastpage" content="1366"> <meta name="citation_pdf_url" content="https://publications.waset.org/9999944/pdf"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="" name="q" aria-label="Search"> <button class="btn btn-light my-2 my-sm-0" type="submit"><i class="fas fa-search"></i></button> </form> </div> <div class="collapse navbar-collapse mt-1" id="navbarMenu"> <ul class="navbar-nav ml-auto align-items-center" id="mainNavMenu"> <li class="nav-item"> <a class="nav-link" href="https://waset.org/conferences" title="Conferences in 2024/2025/2026">Conferences</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/disciplines" title="Disciplines">Disciplines</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/committees" rel="nofollow">Committees</a> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdownPublications" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Publications </a> <div class="dropdown-menu" aria-labelledby="navbarDropdownPublications"> <a class="dropdown-item" href="https://publications.waset.org/abstracts">Abstracts</a> <a class="dropdown-item" href="https://publications.waset.org">Periodicals</a> <a class="dropdown-item" href="https://publications.waset.org/archive">Archive</a> </div> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/page/support" title="Support">Support</a> </li> </ul> </div> </div> </nav> </div> </header> <main> <div class="container mt-4"> <div class="row"> <div class="col-md-9 mx-auto"> <form method="get" action="https://publications.waset.org/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value=""> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 33093</div> </div> </div> </div> <div class="card publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">Grape Seed Extract in Prevention and Treatment of Liver Toxic Cirrhosis in Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=S.%20Buloyan">S. Buloyan</a>, <a href="https://publications.waset.org/search?q=V.%20Mamikonyan"> V. Mamikonyan</a>, <a href="https://publications.waset.org/search?q=H.%20Hakobyan"> H. Hakobyan</a>, <a href="https://publications.waset.org/search?q=H.%20Harutyunyan"> H. Harutyunyan</a>, <a href="https://publications.waset.org/search?q=H.%20Gasparyan"> H. Gasparyan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>The liver is the strongest regenerating organ of the organism, and even with 2/3 surgically removed, it can regenerate completely. Hence liver cirrhosis may only develop when the regenerating system is off. We present the results of a comparative study of structural and functional characteristics of rat liver tissue under the conditions of toxic liver cirrhosis development, induced by carbon tetrachloride, and its prevention/treatment by natural compounds with antioxidant and immune stimulating action. Studies were made on Wister rats, weighing 120~140 g. Grape seeds extracts, separately and in combination with well-known anticirrhotic drug ursodeoxycholic acid (Urdoxa), have demonstrated effectiveness in prevention of liver cirrhosis development and its treatment.</p> <iframe src="https://publications.waset.org/9999944.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Carbon%20tetrachloride" title="Carbon tetrachloride">Carbon tetrachloride</a>, <a href="https://publications.waset.org/search?q=GSE" title=" GSE"> GSE</a>, <a href="https://publications.waset.org/search?q=liver%20cirrhosis" title=" liver cirrhosis"> liver cirrhosis</a>, <a href="https://publications.waset.org/search?q=prevention" title=" prevention"> prevention</a>, <a href="https://publications.waset.org/search?q=treatment." title=" treatment."> treatment.</a> </p> <p class="card-text"><strong>Digital Object Identifier (DOI):</strong> <a href="https://doi.org/10.5281/zenodo.1097285" target="_blank">doi.org/10.5281/zenodo.1097285</a> </p> <a href="https://publications.waset.org/9999944/grape-seed-extract-in-prevention-and-treatment-of-liver-toxic-cirrhosis-in-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/9999944/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/9999944/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/9999944/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/9999944/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/9999944/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/9999944/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/9999944/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/9999944/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/9999944/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/9999944/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/9999944.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">3745</span> </span> <p class="card-text"><strong>References:</strong></p> <br>[1] Day C. P. “Treatment of alcoholic liver disease ” Liv. Transplant, 2007, v. 13, p. 69-75. <br>[2] Emanuel A. “Role of adaptive immunity in alcoholic liver disease” International Journal of Hepatology, v 2012, Article ID 893026, 7 pages. <br>[3] Detlef Schuppan and Nezam H. Afdal “Liver Cirrhosis” The Lancet Vol. 371. Issue 9615, Pages 838 - 851, 8 March 2008 <br>[4] Badavi M., Mehrgardi F.Z., Sarkaki A., Naseri M.K., Dianat M. “Effect of Grape Seed Extract on Lead Induced Hypertension and Heart Rate in Rats.” J. Biol. Sci., 2008, v. 11(6), p. 882-887. <br>[5] Mamikonyan V. “Antioxidant influence of Vitis Vinifera Satira Hayreniq” grape seeds Horizons in Molecular Biology 5th International PhD Student Symposium, Gottingen, Germany, 2008, p. 84. <br>[6] Vivian Molina Cuevas, Yazmín Ravelo Calzado, Yohani Pérez Guerra, Ambar Oyarzábal Yera, Sonia Jiménez Despaigne, Rosa Mas Ferreiro, and Daisy Carbajal Quintana “Effects of Grape Seed Extract, Vitamin C, and Vitamin E on Ethanol- and Aspirin-Induced Ulcers” Advances in Pharmacological Sciences, Volume 2011 (2011), Article ID 740687, 6 pages. <br>[7] Karlen Hovnanyan, Vardan Mamikonyan, Anahit Margaryan, Kristine Sargsyan, Margarita Hovnanyan, Maria Karagyozyan, Konstantin Karageuzyan “Antioxidants as effective remedies at hepatotoxic action of carbon tetrachloride” Journal of Biophysical Chemistry, Vol.5, No.1, 1-4 (2014) <br>[8] Trauner M, Graziadei IW. “Mechanisms of action and therapeutic applications of ursodeoxycholic acid in chronic liver diseases” Aliment Pharmacol Ther. 1999 Aug;13(8):979-96. <br>[9] S. Saksena, R.K. Tandon “Ursodeoxycholic acid in treatment of liver diseases” Postgrad Med J. Feb 1997; 73(856): 75–80. <br>[10] Patrick Sharp, Jason S. Villano “The laboratory rat” second edition p 220-222 <br>[11] Gi-Ppeum Lee, Won-Il Jeong, Da-Hee Jong, Sun-Hee Do, Tae-Hwan Kim and Kyu-shik Jeong, “Diagnostic evaluation of carbon tetrachloride-induced rat hepatic cirrhosis model” Anticancer Research 25, p. 1029-1038, (2005). <br>[12] МЕРКУЛОВ Г.А., 1969, 406 стр. (Merculov G. A., 406 pp). <br>[13] Valeer JD. Liver tissue examination. J Hepatol 2003;39:S43-9. <br>[14] Akram Eidi, Pejman Mortazavi, Masoud Ebrahim Tehrani, Ali Haeri Rohani, Shahabaldin Safi “Hepatoprotective Effects of Pantothenic acid on Carbon Tetrachloride-induced Toxicity in rats” EXCLI Journal 2012;11:748-759 – ISSN 1611-2156 . <br>[15] Zachary D. Goodman “Grading and staging systems for inflammation and fibrosis in chronic liver diseases” Journal of Hepatology, Volume 47, Issue 4, Pages 598–607, October 2007 </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); });*/ jQuery.get({ url: "https://publications.waset.org/xhr/user-menu", cache: false }).then(function(response){ jQuery('#mainNavMenu').append(response); }); }); </script> </body> </html>

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Grape Seed Extract in Prevention and Treatment of Liver Toxic Cirrhosis in Rats