What Cellular Mechanisms are Disrupted by Carcinogens?

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The <a href="">p53 protein</a>, known as the "guardian of the genome," is often mutated in cancer cells. Normally, p53 regulates the cell cycle and promotes apoptosis (programmed cell death) if DNA damage is detected. When p53 is inactivated, cells with damaged DNA continue to divide, leading to tumor formation. Additionally, carcinogens can affect other regulatory proteins like <a href="">retinoblastoma protein (Rb)</a> and signaling pathways like the <a href="">MAPK/ERK pathway</a>, further promoting cellular transformation.</div></div> </div> <hr /> <h3 class="rq-heading">Frequently asked queries:</h3> <div class="qa-container"> <div class="qa-item"> <a href="https://cellbiology.blog/knowledgebase/what-are-carcinogens" title="What are Carcinogens?">What are Carcinogens?</a> </div> <div class="qa-item"> <a href="https://cellbiology.blog/knowledgebase/how-do-carcinogens-affect-cells" title="How Do Carcinogens Affect Cells?">How Do Carcinogens Affect Cells?</a> </div> <div class="qa-item"> <a href="https://cellbiology.blog/knowledgebase/what-cellular-mechanisms-are-disrupted-by-carcinogens" title="What Cellular Mechanisms are Disrupted by Carcinogens?">What Cellular Mechanisms are Disrupted by Carcinogens?</a> </div> <div class="qa-item"> <a href="https://cellbiology.blog/knowledgebase/how-is-exposure-to-carcinogens-measured" title="How is Exposure to Carcinogens Measured?">How is Exposure to Carcinogens Measured?</a> </div> <div class="qa-item"> <a href="https://cellbiology.blog/knowledgebase/what-is-apoptosis" title="What is Apoptosis?">What is Apoptosis?</a> </div> <div class="qa-item"> <a href="https://cellbiology.blog/knowledgebase/what-is-polycystic-ovary-syndrome-pcos" title="What is Polycystic Ovary Syndrome (PCOS)?">What is Polycystic Ovary Syndrome (PCOS)?</a> </div> <div class="qa-item"> <a href="https://cellbiology.blog/knowledgebase/how-are-agonistic-antibodies-developed" title="How Are Agonistic Antibodies Developed?">How Are Agonistic Antibodies Developed?</a> </div> <div class="qa-item"> <a href="https://cellbiology.blog/knowledgebase/what-are-the-key-cellular-players-in-inflammation" title="What are the key cellular players in inflammation?">What are the key cellular players in inflammation?</a> </div> 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therapy"> photothermal therapy </a></li> <li> <a href="https://cellbiology.blog/archive/tag/programmed-cell-death/" title="Programmed cell death"> Programmed cell death </a></li> <li> <a href="https://cellbiology.blog/archive/tag/protein-synthesis-regulation/" title="protein synthesis regulation"> protein synthesis regulation </a></li> <li> <a href="https://cellbiology.blog/archive/tag/rangtp/" title="RanGTP"> RanGTP </a></li> <li> <a href="https://cellbiology.blog/archive/tag/reinitiation/" title="reinitiation"> reinitiation </a></li> <li> <a href="https://cellbiology.blog/archive/tag/ribosome-scanning/" title="ribosome scanning"> ribosome scanning </a></li> <li> <a href="https://cellbiology.blog/archive/tag/rna-export/" title="RNA export"> RNA export </a></li> <li> <a href="https://cellbiology.blog/archive/tag/rna-export-mechanisms/" title="RNA export mechanisms"> RNA export mechanisms </a></li> <li> <a href="https://cellbiology.blog/archive/tag/rna-binding-proteins/" title="RNA-binding proteins"> RNA-binding proteins </a></li> <li> <a href="https://cellbiology.blog/archive/tag/targeted-drug-delivery/" title="targeted drug delivery"> targeted drug delivery </a></li> <li> <a href="https://cellbiology.blog/archive/tag/translational-control/" title="Translational control"> Translational control </a></li> <li> <a href="https://cellbiology.blog/archive/tag/upstream-open-reading-frames-uorfs/" title="upstream open reading frames (uORFs)"> upstream open reading frames (uORFs) </a></li> <li> <a href="https://cellbiology.blog/archive/tag/viral-translation/" title="viral translation"> viral translation </a></li> </ul> </div> </div> <footer id="footer" class="footer"> <div class="container"> <div class="footer-menu"> <div class="row"> <div class="col-sm-3"> <p> ©2024 Cell Biology </p> </div> <div class="col-sm-9"> <ul class="footer-menu-item"> <li class="scroll"><a href="https://cellbiology.blog/archive/privacy-policy/">Privacy Policy</a></li> <li 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