The American Journal of Surgical Pathology

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content="1" /><meta name="wkhealth_article_publication_date" content="August 12, 2020" /><meta name="wkhealth_volume" content="45" /><meta name="wkhealth_ovid_accession_number" content="00000478-202101000-00001" /><meta name="wkhealth_issn" content="0147-5185" /><meta name="wkhealth_title" content="The 2020 WHO Classification: What’s New in Soft Tissue Tumor Pathology?" /><meta name="wkhealth_authors" content="Kallen, Michael E.;Hornick, Jason L." /><meta name="wkhealth_doi" content="10.1097/PAS.0000000000001552" /><meta name="wkhealth_abstract_html_url" content="https://journals.lww.com/ajsp/abstract/2021/01000/the_2020_who_classification__what_s_new_in_soft.1.aspx" /><meta name="wkhealth_fulltext_html_url" content="https://journals.lww.com/ajsp/fulltext/2021/01000/the_2020_who_classification__what_s_new_in_soft.1.aspx" /><meta name="wkhealth_toc_section" content="Special Article" /><meta name="wkhealth_toc_sub_section" /><meta name="wkhealth_eJpId" content="ajsp:2021:01000:00001" /><meta name="wkhealth_firstpage" content="e1" /><meta name="wkhealth_date" content="January 2021" /><meta name="wkhealth_pdf_url" content="https://journals.lww.com/ajsp/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=Other&an=00000478-202101000-00001" /><meta name="Description" content="The fifth edition of the World Health Organization Classification of Tumors of Soft Tissue and Bone " /><meta property="og:site_name" content="LWW" /><meta property="og:type" content="article" /><meta property="og:title" content="The 2020 WHO Classification: What’s New in Soft Tissue... : The American Journal of Surgical Pathology" /><meta property="og:description" content="n, and radiologist. The changes in the soft tissue tumor chapter notably include diverse, recently described tumor types (eg, atypical spindle cell/pleomorphic lipomatous tumor, angiofibroma of soft tissue, and CIC-rearranged sarcoma), new clinically significant prognostic information for a variety of existing entities (eg, dedifferentiated liposarcoma and solitary fibrous tumor), and a plethora of novel genetic alterations, some of practical diagnostic relevance (eg, NAB2-STAT6 in solitary fibrous tumor, FOSB rearrangements in epithelioid hemangioma and pseudomyogenic hemangioendothelioma, and SUZ12 or EED mutations in malignant peripheral nerve sheath tumor, leading to loss of H3K27 trimethylation). In this review, we highlight the major changes to the soft tissue chapter in the 2020 World Health Organization Classification, as well as the new chapter on undifferentiated small round cell sarcomas, with a focus on updates in diagnostic categories, prognostication, and novel markers. 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A, This tumor shows a variably collagenous to myxoid stroma and is dominated by spindle cells, in areas admixed with adipocytes. B, The tumor cells are relatively uniform, whereas the adipocytes show marked variation in size, including occasional lipoblasts. C, This tumor contains abundant myxoid stroma with prominent adipocytes and scattered spindle cells with hyperchromatic nuclei. D, This example shows dense collagenous stroma, notably pleomorphic and multinucleated cells, and occasional lipoblasts.","https://images.journals.lww.com/ajsp/Rollover.00000478-202101000-00001.F1.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202101000-00001.F1.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2021:01000:00001&i=F1&year=2021&issue=01000&article=00001&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202101000-00001.F1.jpeg","/ajsp/pages/imagegallery.aspx?year=2021&issue=01000&article=00001", "ajsp_2021_01000_00001_F1");images["F2"]=new image("F2","F3","F1","FIGURE 2","Myxoid pleomorphic liposarcoma. A, The tumor contains abundant myxoid stroma and “crow’s feet” blood vessels, mimicking myxoid liposarcoma; the presence of tumor cells with large, hyperchromatic nuclei would not fit with myxoid liposarcoma. B, In other areas, markedly pleomorphic cells and atypical lipoblasts resemble pleomorphic liposarcoma.","https://images.journals.lww.com/ajsp/Rollover.00000478-202101000-00001.F2.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202101000-00001.F2.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2021:01000:00001&i=F2&year=2021&issue=01000&article=00001&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202101000-00001.F2.jpeg","/ajsp/pages/imagegallery.aspx?year=2021&issue=01000&article=00001", "ajsp_2021_01000_00001_F2");images["F3"]=new image("F3","F4","F2","FIGURE 3","Angiofibroma of soft tissue. A, The tumor shows a hypocellular appearance with evenly distributed, branching blood vessels and a fine collagenous stroma. B, Some examples contain myxoid stroma. Note the prominent thin-walled blood vessels. C, The uniform ovoid to short spindle cells contain fine chromatin. D, The characteristic blood vessels are generally thicker in caliber than similarly shaped vessels of myxoid liposarcoma.","https://images.journals.lww.com/ajsp/Rollover.00000478-202101000-00001.F3.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202101000-00001.F3.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2021:01000:00001&i=F3&year=2021&issue=01000&article=00001&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202101000-00001.F3.jpeg","/ajsp/pages/imagegallery.aspx?year=2021&issue=01000&article=00001", "ajsp_2021_01000_00001_F3");images["F4"]=new image("F4","F5","F3","FIGURE 4","<em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">EWSR1-SMAD3</em>-positive fibroblastic tumor. A, Intersecting fascicles of spindle cells show irregular margins with adjacent subcutaneous adipose tissue. B, The fibroblastic spindle cells contain uniform nuclei and pale eosinophilic cytoplasm.","https://images.journals.lww.com/ajsp/Rollover.00000478-202101000-00001.F4.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202101000-00001.F4.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2021:01000:00001&i=F4&year=2021&issue=01000&article=00001&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202101000-00001.F4.jpeg","/ajsp/pages/imagegallery.aspx?year=2021&issue=01000&article=00001", "ajsp_2021_01000_00001_F4");images["F5"]=new image("F5","F6","F4","FIGURE 5","Superficial CD34-positive fibroblastic tumor. A, The tumor is composed of sheets of variably pleomorphic and epithelioid cells with abundant, glassy eosinophilic cytoplasm. Mitotic activity is minimal, in contrast to undifferentiated pleomorphic sarcoma. B, IHC for CD34 is diffusely positive. Keratins are also often positive (not shown).","https://images.journals.lww.com/ajsp/Rollover.00000478-202101000-00001.F5.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202101000-00001.F5.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2021:01000:00001&i=F5&year=2021&issue=01000&article=00001&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202101000-00001.F5.jpeg","/ajsp/pages/imagegallery.aspx?year=2021&issue=01000&article=00001", "ajsp_2021_01000_00001_F5");images["F6"]=new image("F6","F7","F5","FIGURE 6","Inflammatory leiomyosarcoma. A, The tumor is composed of relatively uniform, elongated spindle cells with eosinophilic cytoplasm, including scattered atypical forms, admixed with prominent lymphocytes and scattered foam cells. B, Desmin is typically strongly positive.","https://images.journals.lww.com/ajsp/Rollover.00000478-202101000-00001.F6.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202101000-00001.F6.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2021:01000:00001&i=F6&year=2021&issue=01000&article=00001&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202101000-00001.F6.jpeg","/ajsp/pages/imagegallery.aspx?year=2021&issue=01000&article=00001", "ajsp_2021_01000_00001_F6");images["F7"]=new image("F7","F8","F6","FIGURE 7","<em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">NTRK</em>-rearranged spindle cell neoplasms. A, This group of tumors shows a range of histologic appearances and sometimes resembles nerve sheath tumors, ranging from (A) hypocellular tumors with bland spindle cells in a collagenous stroma to (B) more cellular examples with mitotically active, atypical spindle cells in a myxoid stroma. Note the perivascular hyalinized collagen, similar to the vascular pattern observed in schwannomas. C, Some tumors show a focally nodular or whorled appearance. D, IHC using a pan-TRK antibody is usually positive, most strongly and diffusely in tumors with <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">NTRK1</em> rearrangements. Weak or moderate staining is not entirely specific for this tumor class.","https://images.journals.lww.com/ajsp/Rollover.00000478-202101000-00001.F7.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202101000-00001.F7.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2021:01000:00001&i=F7&year=2021&issue=01000&article=00001&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202101000-00001.F7.jpeg","/ajsp/pages/imagegallery.aspx?year=2021&issue=01000&article=00001", "ajsp_2021_01000_00001_F7");images["F8"]=new image("F8","F9","F7","FIGURE 8","<em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">CIC</em>-rearranged sarcoma. A, This tumor is composed of sheets of round cells somewhat resembling Ewing sarcoma, although the amount of cytoplasm and uneven spacing of nuclei would be unusual. B, The tumor cells often contain prominent nucleoli and abundant pale cytoplasm, helpful clues to the diagnosis. C, Epithelioid tumor cells with clear cytoplasm are a focal finding in many cases. D, This example contains an admixture of rounded to epithelioid cells with amphophilic cytoplasm. Note the extensive necrosis. The combination of nuclear WT-1 (E) and ETV4 (F) is helpful to support the diagnosis.","https://images.journals.lww.com/ajsp/Rollover.00000478-202101000-00001.F8.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202101000-00001.F8.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2021:01000:00001&i=F8&year=2021&issue=01000&article=00001&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202101000-00001.F8.jpeg","/ajsp/pages/imagegallery.aspx?year=2021&issue=01000&article=00001", "ajsp_2021_01000_00001_F8");images["F9"]=new image("F9","F10","F8","FIGURE 9","Sarcomas with <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">BCOR</em> genetic alterations. A, This tumor is composed of uniform round cells with fine chromatin in a fibrillary collagenous stroma. B, Some examples contain myxoid stroma and thin-walled blood vessels. C, A component of short spindle cells is often seen. D, Diffuse nuclear staining for BCOR is a characteristic finding, albeit not entirely specific for tumors with <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">BCOR</em> gene alterations.","https://images.journals.lww.com/ajsp/Rollover.00000478-202101000-00001.F9.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202101000-00001.F9.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2021:01000:00001&i=F9&year=2021&issue=01000&article=00001&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202101000-00001.F9.jpeg","/ajsp/pages/imagegallery.aspx?year=2021&issue=01000&article=00001", "ajsp_2021_01000_00001_F9");images["F10"]=new image("F10","F11","F9","FIGURE 10","Round cell sarcomas with <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">EWSR1</em>-<em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">PATZ1</em> fusions. A, This tumor contains an admixture of round cells and epithelioid cells. Note the bland nuclei. B, Some tumors show a reticular growth pattern with short spindle cells in a more myxoid stroma. C, The histology of these tumors is often reminiscent of myoepithelial neoplasms. Note the perivascular hyalinization. D, IHC for S100 protein is often positive, further mimicking a myoepithelial tumor.","https://images.journals.lww.com/ajsp/Rollover.00000478-202101000-00001.F10.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202101000-00001.F10.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2021:01000:00001&i=F10&year=2021&issue=01000&article=00001&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202101000-00001.F10.jpeg","/ajsp/pages/imagegallery.aspx?year=2021&issue=01000&article=00001", "ajsp_2021_01000_00001_F10");images["F11"]=new image("F11","F12","F10","FIGURE 11","MMNST. A, Some examples contain abundant melanin pigment, obscuring the tumor cells. B, This tumor contains less prominent melanin. The uniform spindle cells show a fascicular architecture. C, Some tumors show a melanoma-like appearance with epithelioid cells with prominent nucleoli and a high mitotic rate. D, By IHC, many examples show loss of staining for PRKAR1A (red reaction product).","https://images.journals.lww.com/ajsp/Rollover.00000478-202101000-00001.F11.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202101000-00001.F11.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2021:01000:00001&i=F11&year=2021&issue=01000&article=00001&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202101000-00001.F11.jpeg","/ajsp/pages/imagegallery.aspx?year=2021&issue=01000&article=00001", "ajsp_2021_01000_00001_F11");images["F12"]=new image("F12","F13","F11","FIGURE 12","SFT. A, The tumor contains prominent stromal collagen and shows a haphazard architecture. B, This tumor shows a more cellular appearance. Note the scattered dilated, thin-walled blood vessels. C, A highly cellular example with prominent staghorn vessels. This high-risk tumor had a high mitotic rate (not shown). D, Nuclear immunoreactivity for STAT6 is a consistent finding, reflecting the underlying <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">NAB2-STAT6</em> fusion that defines this tumor type.","https://images.journals.lww.com/ajsp/Rollover.00000478-202101000-00001.F12.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202101000-00001.F12.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2021:01000:00001&i=F12&year=2021&issue=01000&article=00001&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202101000-00001.F12.jpeg","/ajsp/pages/imagegallery.aspx?year=2021&issue=01000&article=00001", "ajsp_2021_01000_00001_F12");images["F13"]=new image("F13","F14","F12","FIGURE 13","Epithelioid hemangioma. A, A cellular example with nests of epithelioid tumor cells with abundant eosinophilic cytoplasm and occasional vacuoles. B, Nuclear staining for FOSB is a helpful diagnostic finding, identified in around 50% of cases.","https://images.journals.lww.com/ajsp/Rollover.00000478-202101000-00001.F13.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202101000-00001.F13.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2021:01000:00001&i=F13&year=2021&issue=01000&article=00001&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202101000-00001.F13.jpeg","/ajsp/pages/imagegallery.aspx?year=2021&issue=01000&article=00001", "ajsp_2021_01000_00001_F13");images["F14"]=new image("F14","F15","F13","FIGURE 14","EHE. A, Conventional EHE composed of uniform epithelioid cells with glassy eosinophilic cytoplasm arranged in cords within a myxohyaline stroma. B, EHE with <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">YAP1-TFE3</em> fusion often shows a nested appearance; the tumor cells contain abundant pale eosinophilic cytoplasm. C, A focally vasoformative architecture is usually seen, in contrast to conventional EHE. The degree of nuclear atypia in this case is notable. D, IHC for TFE3 shows strong nuclear staining.","https://images.journals.lww.com/ajsp/Rollover.00000478-202101000-00001.F14.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202101000-00001.F14.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2021:01000:00001&i=F14&year=2021&issue=01000&article=00001&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202101000-00001.F14.jpeg","/ajsp/pages/imagegallery.aspx?year=2021&issue=01000&article=00001", "ajsp_2021_01000_00001_F14");images["F15"]=new image("F15","F16","F14","FIGURE 15","Pseudomyogenic hemangioendothelioma. A, The tumor shows a loose fascicular architecture with relatively uniform spindle cells with abundant eosinophilic cytoplasm, mimicking a myoid neoplasm. Note the scattered stromal neutrophils. B, This example infiltrates muscle and contains polygonal to spindle cells with amphophilic cytoplasm. C, By IHC, the tumor cells are diffusely positive for keratins using AE1/AE3 (but not MNF116). D, FOSB is strongly positive, reflecting an underlying <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">FOSB</em> gene rearrangement.","https://images.journals.lww.com/ajsp/Rollover.00000478-202101000-00001.F15.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202101000-00001.F15.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2021:01000:00001&i=F15&year=2021&issue=01000&article=00001&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202101000-00001.F15.jpeg","/ajsp/pages/imagegallery.aspx?year=2021&issue=01000&article=00001", "ajsp_2021_01000_00001_F15");images["F16"]=new image("F16","","F15","FIGURE 16","MPNST. A, The tumor shows alternating highly cellular, fascicular areas and less cellular areas. 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Classification: What’s New in Soft Tissue Tumor Pathology?', '08122020', 'Michael E. Kallen and Jason L. Hornick', '45', '1', 'Copyright \u00A9 2020 Wolters Kluwer Health, Inc. All rights reserved.', '00000478-202101000-00001', '', false, ''); } </script> <div id="ArticleContainer"> <article id="ej-abstract-view" xmlns:ssr="http://ssr-eus-go-csi.cloudapp.net/v1/assets" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xhtml="http://www.w3.org/1999/xhtml"><section class="ejp-r-article-subsection"><div class="ejp-r-article-subsection__text">Special Article</div></section><header class="ejp-article-header"><h1 class="ejp-article-title">The 2020 WHO Classification</h1> <h2 class="article-subtitle">What’s New in Soft Tissue Tumor Pathology?</h2></header><section id="ejp-article-authors"><p id="P7">Kallen, Michael E. MD<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">*</sup>; Hornick, Jason L. MD, PhD<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">†</sup></p><section><a href="#" id="ejp-article-authors-link"> Author Information <i class="wk-icon-arrow-down-r"></i></a></section></section><section id="ejp-article-authors-info" class="ejp-article-authors-info ejp-article-authors-info--hidden"><div class="ejp-article-authors-info-holder"> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">*</sup>Department of Pathology, University of Maryland School of Medicine, Baltimore, MD</p> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">†</sup>Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA</p> <p id="">Conflicts of Interest and Source of Funding: J.L.H. is a consultant to Epizyme, Aadi Biosciences, and TRACON Pharmaceuticals. For M.E.K. none was declared.</p> <p id="">Correspondence: Jason L. Hornick, MD, PhD, Department of Pathology, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115 (e-mail: <span><a href="/cdn-cgi/l/email-protection#79141810150d16431311160b17101a12391b0e115711180b0f180b1d571c1d0c" onclick="javascript:window.open('mailto:mailto:jhornick@bwh.harvard.edu');return false"><span class="__cf_email__" data-cfemail="5b31333429353238301b392c3375333a292d3a293f753e3f2e">[email protected]</span></a></span>).</p> </div></section><section id="article-journal-info"><div class="ej-journal-info"><span class="ej-journal-name">The American Journal of Surgical Pathology </span><span id="ej-journal-date-volume-issue-pg"><a href="/ajsp/toc/2021/01000">45(1):p e1-e23, January 2021.</a></span><span> | </span><span class="ej-journal-doi">DOI: </span>10.1097/PAS.0000000000001552</div></section><section id="ejp-article-indicators" class="ejp-article-indicators"><ul class="ejp-article-indicators__list"> <li id="ej-article-indicators-buy" class="ejp-article-indicators__list-item" onmouseover="javascript:Tooltip_Buy()" onmouseout="javascript:Tooltip_MouseOut()"><a href="#ContentAccessOptions"><span class="ejp-indicator">Buy</span></a></li> </ul><button id="openArticleMetricsPopupButton" type="button" class="wk-button wk-button-ghost wk-button-icon-left ejp-article-metrics-btn" data-articleMetricsEndpoint="//services.journals.lww.com/IntegrationServices/ArticleMetricsService.svc" data-articleMetricsDetailsUrl="https://wolterskluwer.altmetric.com/details/" data-doi="10.1097/PAS.0000000000001552" data-suiteId="vrs_woltere_journalsglobalvrs" data-articlePublicationDate="2020-08-12" data-articlePublicationDateString="August 12, 2020" data-receivedDate="" data-revisionReceivedDate="" data-acceptedDate="" data-crossrefRefLinkRoot="https://doi.org/" data-medlineRefLinkRoot="http://www.ncbi.nlm.nih.gov/pubmed/" data-pubMedId="32796172"><i class="wk-icon-filled-chart-r"></i><i class="wk-icon-filled-chart-white-r"></i> Metrics </button></section><section class="ejp-article-tabs" id="abstractWrap"><h2 class="ejp-article-tabs-heading">Abstract</h2> <div class="ejp-article-tabs__tabpanel" id="panel1" role="tabpanel" aria-labelledby="tab1"> <div id="article-abstract-content1"> <div class="ejp-article-text-abstract"> <p>The fifth edition of the World Health Organization Classification of Tumors of Soft Tissue and Bone was published in early 2020. The revisions reflect a consensus among an international expert editorial board composed of soft tissue and bone pathologists, geneticists, a medical oncologist, surgeon, and radiologist. The changes in the soft tissue tumor chapter notably include diverse, recently described tumor types (eg, atypical spindle cell/pleomorphic lipomatous tumor, angiofibroma of soft tissue, and <em xmlns:mrws="http://webservices.ovid.com/mrws/1.0">CIC</em>-rearranged sarcoma), new clinically significant prognostic information for a variety of existing entities (eg, dedifferentiated liposarcoma and solitary fibrous tumor), and a plethora of novel genetic alterations, some of practical diagnostic relevance (eg, <em xmlns:mrws="http://webservices.ovid.com/mrws/1.0">NAB2-STAT6</em> in solitary fibrous tumor, <em xmlns:mrws="http://webservices.ovid.com/mrws/1.0">FOSB</em> rearrangements in epithelioid hemangioma and pseudomyogenic hemangioendothelioma, and <em xmlns:mrws="http://webservices.ovid.com/mrws/1.0">SUZ12</em> or <em xmlns:mrws="http://webservices.ovid.com/mrws/1.0">EED</em> mutations in malignant peripheral nerve sheath tumor, leading to loss of H3K27 trimethylation). In this review, we highlight the major changes to the soft tissue chapter in the 2020 World Health Organization Classification, as well as the new chapter on undifferentiated small round cell sarcomas, with a focus on updates in diagnostic categories, prognostication, and novel markers. Recent discoveries in molecular genetics are also discussed, particularly those of immediate utility in differential diagnosis, including protein correlates detectable using immunohistochemistry.</p> </div> </div> </div></section><section class="ej-article-copyright">Copyright © 2020 Wolters Kluwer Health, Inc. 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id="ctl00_ctl29_g_55b6e16c_7ed5_4ab6_a182_34f5ecf40587"> <div data-config="{"serviceUrl":null,"displayMode":null,"hash":"1","itemsPerPage":40,"renderOnServer":false}"></div><section id="ctl00_ctl29_g_55b6e16c_7ed5_4ab6_a182_34f5ecf40587_ctl01_divRecentActivity" class="content-box cb-collapsible"> <div class="ejp-uc--small"> <header class="ejp-heading-2"> <h2 aria-expanded="false"> Readers Of this Article Also Read </h2> </header> <div id="ej-box-01-body"> <div id="ej-articlesWithTerms"> <ul> <li class="ejp-uc__list-item"> <h3 class='ejp-uc__article-title'><a title href="https://journals.lww.com/ajsp/abstract/2013/02000/papillary_proliferation_of_the_endometrium__a.2.aspx" onmouseover="javascript:event.cancelBubble = true;Tooltip_Article('Papillary Proliferation of the Endometrium: A Clinicopathologic Study of 59 Cases of Simple and Complex Papillae Without Cytologic Atypia', 'Ip Philip P.C. 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To keep this Web Part, click Cancel.';var lblColleaguesEmail = $get('ctl00_ctl29_g_60b9c391_4bd7_4f45_ae6b_9b5338b7d65c_ctl00_ucArticleTools_emailToColleagueControl_lblColleaguesEmail'); var Page_ValidationActive = false; if (typeof(ValidatorOnLoad) == "function") { ValidatorOnLoad(); } function ValidatorOnSubmit() { if (Page_ValidationActive) { return ValidatorCommonOnSubmit(); } else { return true; } } //]]> </script> <script type='text/javascript'>SP.SOD.set_prefetch(0);</script> <script type="text/javascript"> //<![CDATA[ WPSC.Init(document); var varPartWPQ1 = WPSC.WebPartPage.Parts.Register('WPQ1','ce0f8ecf-65f7-4a26-939e-2bbb37977f2c',document.getElementById('WebPartWPQ1')); var varPartWPQ2 = WPSC.WebPartPage.Parts.Register('WPQ2','48ec8185-1b32-4da1-96aa-6c91a856c108',document.getElementById('WebPartWPQ2')); var varPartWPQ3 = WPSC.WebPartPage.Parts.Register('WPQ3','2a05994c-ddb4-4373-b9a1-049ed15429cc',document.getElementById('WebPartWPQ3')); var varPartWPQ4 = WPSC.WebPartPage.Parts.Register('WPQ4','55b6e16c-7ed5-4ab6-a182-34f5ecf40587',document.getElementById('WebPartWPQ4')); var varPartWPQ5 = WPSC.WebPartPage.Parts.Register('WPQ5','c790b33c-5b93-4b04-adb5-f1eb6d570c4c',document.getElementById('WebPartWPQ5')); var varPartWPQ6 = WPSC.WebPartPage.Parts.Register('WPQ6','8dcc7734-ef3b-4dad-8855-ec5f7e54440d',document.getElementById('WebPartWPQ6')); WPSC.WebPartPage.WebURL = 'https:\u002f\u002fjournals.lww.com\u002fajsp'; WPSC.WebPartPage.WebServerRelativeURL = '\u002fajsp'; var g_clientIdDeltaPlaceHolderMain = "DeltaPlaceHolderMain"; var g_clientIdDeltaPlaceHolderUtilityContent = "DeltaPlaceHolderUtilityContent"; WebForm_AutoFocus('ctl00_ctl29_g_60b9c391_4bd7_4f45_ae6b_9b5338b7d65c_ctl00_emailToColleague_txtYourName');Sys.Application.add_init(function() { $create(AjaxControlToolkit.ModalPopupBehavior, {"BackgroundCssClass":"Popup-Overlay","DropShadow":true,"PopupControlID":"ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pnlunSubscribeToAlerts","dynamicServicePath":"/ajsp/pages/articleviewer.aspx","id":"unSubscribeToAlerts"}, null, null, $get("ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_dummyTargetControl")); }); Sys.Application.add_init(function() { $create(AjaxControlToolkit.ModalPopupBehavior, {"BackgroundCssClass":"Popup-Overlay","DropShadow":true,"PopupControlID":"ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlSubscribeToEtoc","dynamicServicePath":"/ajsp/pages/articleviewer.aspx","id":"subscribeToEtoc"}, null, null, $get("ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_dummyTargetControl")); }); document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_cvEmailError').dispose = function() { Array.remove(Page_Validators, document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_cvEmailError')); } g_QuickLaunchControlIds.push("zz1_TopNavigationMenu");_spBodyOnLoadFunctionNames.push('QuickLaunchInitDroppable'); var g_zz1_TopNavigationMenu = null; function init_zz1_TopNavigationMenu() { if (g_zz1_TopNavigationMenu == null) g_zz1_TopNavigationMenu = $create(SP.UI.AspMenu, null, null, null, $get('zz1_TopNavigationMenu')); } if(g_spPreFetchKeys) {{ g_spPreFetchKeys.push('SP.Core.js');}}EnsureScriptFunc('SP.Core.js', 'SP.UI.AspMenu', init_zz1_TopNavigationMenu); Sys.Application.add_init(function() { $create(AjaxControlToolkit.ModalPopupBehavior, {"BackgroundCssClass":"Popup-Overlay","PopupControlID":"ctl00_ctl29_g_60b9c391_4bd7_4f45_ae6b_9b5338b7d65c_ctl00_ucArticleTools_emailToColleagueControl_pnlEmailToColleague","dynamicServicePath":"/ajsp/pages/articleviewer.aspx","id":"emailToColleaguePopupExtender_1605895285"}, null, null, $get("ctl00_ctl29_g_60b9c391_4bd7_4f45_ae6b_9b5338b7d65c_ctl00_ucArticleTools_emailToColleagueControl_hypEmailToColleague")); }); Sys.Application.add_init(function() { $create(AjaxControlToolkit.ModalPopupBehavior, {"BackgroundCssClass":"Popup-Overlay","PopupControlID":"ctl00_ctl29_g_60b9c391_4bd7_4f45_ae6b_9b5338b7d65c_ctl00_ucArticleTools_exportToCitationManager_pnlExportTo","dynamicServicePath":"/ajsp/pages/articleviewer.aspx","id":"OpenExportToPopupExtender_566456402"}, null, null, $get("ctl00_ctl29_g_60b9c391_4bd7_4f45_ae6b_9b5338b7d65c_ctl00_ucArticleTools_exportToCitationManager_hypExportToCitationManager")); 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