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class="elementor-element elementor-element-96796a7 elementor-widget elementor-widget-heading" data-id="96796a7" data-element_type="widget" data-settings="{"_animation":"none","_animation_tablet":"none"}" data-widget_type="heading.default"> <div class="elementor-widget-container"> <style>/*! elementor - v3.18.0 - 20-12-2023 */ .elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}</style><h1 class="elementor-heading-title elementor-size-default">applications</h1> </div> </div> <div class="elementor-element elementor-element-15495ba elementor-widget elementor-widget-text-editor" data-id="15495ba" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <style>/*! elementor - v3.18.0 - 20-12-2023 */ .elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}</style> <p>Discover how QF-Pro® is transforming clinical biomarker research</p> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-174e4bf elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="174e4bf" data-element_type="section" data-settings="{"background_background":"classic"}"> <div class="elementor-container elementor-column-gap-no"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5523201" data-id="5523201" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-background-overlay"></div> <div class="elementor-element elementor-element-5acefa3 elementor-widget elementor-widget-text-editor" data-id="5acefa3" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Understanding the intricate interactions of proteins is crucial for deciphering biological processes. Proteins govern a plethora of functions and serve as pivotal targets in health and disease. QF-Pro® not only enhances our understanding of biological pathways and protein functional states but also facilitates the identification of new biomarkers at single-cell resolution. Moreover, it enables deep phenotypic profiling in both cell and tissue models, providing early insights into drug mechanism of action and facilitating precise drug target engagement in tissues.</p> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-a80f6c4 elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="a80f6c4" data-element_type="section"> <div class="elementor-container elementor-column-gap-no"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-ad05ca0" data-id="ad05ca0" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-2fd5045 elementor-widget elementor-widget-image" data-id="2fd5045" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" width="1500" height="1000" src="https://www.hawkbiosystems.com/wp-content/uploads/2024/04/intercellular-PPIs.jpg" class="attachment-full size-full wp-image-3337" alt="" srcset="https://www.hawkbiosystems.com/wp-content/uploads/2024/04/intercellular-PPIs.jpg 1500w, https://www.hawkbiosystems.com/wp-content/uploads/2024/04/intercellular-PPIs-300x200.jpg 300w, https://www.hawkbiosystems.com/wp-content/uploads/2024/04/intercellular-PPIs-1024x683.jpg 1024w, https://www.hawkbiosystems.com/wp-content/uploads/2024/04/intercellular-PPIs-768x512.jpg 768w" sizes="(max-width: 1500px) 100vw, 1500px" /> </div> </div> <div class="elementor-element elementor-element-57d02da elementor-widget elementor-widget-heading" data-id="57d02da" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default"><a href="#ppisptms">PPIs & PTMs</a></h3> </div> </div> <div class="elementor-element elementor-element-ad3f9b4 elementor-mobile-align-center elementor-align-center elementor-tablet-align-center elementor-widget elementor-widget-button" data-id="ad3f9b4" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="#PPIs"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">More information</span> </span> </a> </div> </div> </div> </div> </div> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-d6b30c4" data-id="d6b30c4" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-b6aa6b9 elementor-widget elementor-widget-image" data-id="b6aa6b9" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" width="500" height="350" src="https://www.hawkbiosystems.com/wp-content/uploads/2024/05/immuno-oncology-background.png" class="attachment-full size-full wp-image-4682" alt="" srcset="https://www.hawkbiosystems.com/wp-content/uploads/2024/05/immuno-oncology-background.png 500w, https://www.hawkbiosystems.com/wp-content/uploads/2024/05/immuno-oncology-background-300x210.png 300w" sizes="(max-width: 500px) 100vw, 500px" /> </div> </div> <div class="elementor-element elementor-element-e3b0a10 elementor-widget elementor-widget-heading" data-id="e3b0a10" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default"><a href="#inmunooncology">Immuno-Oncology</a></h3> </div> </div> <div class="elementor-element elementor-element-d24d2f7 elementor-mobile-align-center elementor-align-center elementor-tablet-align-center elementor-widget elementor-widget-button" data-id="d24d2f7" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="#inmunooncology"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">More information</span> </span> </a> </div> </div> </div> </div> </div> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-841cbee" data-id="841cbee" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-7e2d805 elementor-widget elementor-widget-image" data-id="7e2d805" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="1500" height="998" src="https://www.hawkbiosystems.com/wp-content/uploads/2024/04/qf-pro-reagentskit.jpg" class="attachment-full size-full wp-image-3325" alt="" srcset="https://www.hawkbiosystems.com/wp-content/uploads/2024/04/qf-pro-reagentskit.jpg 1500w, https://www.hawkbiosystems.com/wp-content/uploads/2024/04/qf-pro-reagentskit-300x200.jpg 300w, https://www.hawkbiosystems.com/wp-content/uploads/2024/04/qf-pro-reagentskit-1024x681.jpg 1024w, https://www.hawkbiosystems.com/wp-content/uploads/2024/04/qf-pro-reagentskit-768x511.jpg 768w" sizes="(max-width: 1500px) 100vw, 1500px" /> </div> </div> <div class="elementor-element elementor-element-d0b64a5 elementor-widget elementor-widget-heading" data-id="d0b64a5" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default"><a href="#casestudies">Case Studies</a></h3> </div> </div> <div class="elementor-element elementor-element-9e49032 elementor-mobile-align-center elementor-align-center elementor-tablet-align-center elementor-widget elementor-widget-button" data-id="9e49032" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="#casestudies"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">More information</span> </span> </a> </div> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-53c6d62 elementor-section-content-middle elementor-reverse-tablet elementor-reverse-mobile elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="53c6d62" data-element_type="section" data-settings="{"background_background":"classic"}"> <div class="elementor-container elementor-column-gap-no"> <div class="elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2a7f2f6" data-id="2a7f2f6" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-background-overlay"></div> <div class="elementor-element elementor-element-ef3eb51 elementor-widget elementor-widget-menu-anchor" data-id="ef3eb51" data-element_type="widget" data-widget_type="menu-anchor.default"> <div class="elementor-widget-container"> <style>/*! elementor - v3.18.0 - 20-12-2023 */ body.elementor-page .elementor-widget-menu-anchor{margin-bottom:0}</style> <div id="PPIs" class="elementor-menu-anchor"></div> </div> </div> <div class="elementor-element elementor-element-9d4553c elementor-widget elementor-widget-heading" data-id="9d4553c" data-element_type="widget" data-settings="{"_animation":"none","_animation_tablet":"none"}" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">Protein-Protein Interactions<br>(PPIs)</h3> </div> </div> <div class="elementor-element elementor-element-66cfe9a elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="66cfe9a" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <style>/*! elementor - v3.18.0 - 20-12-2023 */ .elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#0c0d0e;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:flex}.elementor-widget-divider .elementor-divider__text{font-size:15px;line-height:1;max-width:95%}.elementor-widget-divider .elementor-divider__element{margin:0 var(--divider-element-spacing);flex-shrink:0}.elementor-widget-divider .elementor-icon{font-size:var(--divider-icon-size)}.elementor-widget-divider .elementor-divider-separator{display:flex;margin:0;direction:ltr}.elementor-widget-divider--view-line_icon .elementor-divider-separator,.elementor-widget-divider--view-line_text .elementor-divider-separator{align-items:center}.elementor-widget-divider--view-line_icon .elementor-divider-separator:after,.elementor-widget-divider--view-line_icon .elementor-divider-separator:before,.elementor-widget-divider--view-line_text .elementor-divider-separator:after,.elementor-widget-divider--view-line_text .elementor-divider-separator:before{display:block;content:"";border-bottom:0;flex-grow:1;border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--element-align-left .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-left .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-left .elementor-divider__element{margin-left:0}.elementor-widget-divider--element-align-right .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-right .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-right .elementor-divider__element{margin-right:0}.elementor-widget-divider:not(.elementor-widget-divider--view-line_text):not(.elementor-widget-divider--view-line_icon) .elementor-divider-separator{border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--separator-type-pattern{--divider-border-style:none}.elementor-widget-divider--separator-type-pattern.elementor-widget-divider--view-line .elementor-divider-separator,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:after,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:before,.elementor-widget-divider--separator-type-pattern:not([class*=elementor-widget-divider--view]) .elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%);--flex-grow:var(--container-widget-flex-grow)}</style> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-15a44fd elementor-widget elementor-widget-text-editor" data-id="15a44fd" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>QF-Pro® can be used in order to quantify a range of protein-protein interactions (PPIs) within tissue samples.</p><p><span style="font-family: var( --e-global-typography-8b7e80d-font-family ), Sans-serif; font-size: var( --e-global-typography-8b7e80d-font-size ); font-weight: var( --e-global-typography-8b7e80d-font-weight ); letter-spacing: var( --e-global-typography-8b7e80d-letter-spacing ); word-spacing: var( --e-global-typography-8b7e80d-word-spacing );">This includes intracellular PPIs such as HER2/HER3 dimerisation or Akt/PDK1 interaction states. QF-Pro® can also quantify intercellular interaction states such as those of immune checkpoints, i.e., PD-1/PD-L1, CTLA-4/CD80, TIGIT/CD155.</span></p><p><span style="font-family: var( --e-global-typography-8b7e80d-font-family ), Sans-serif; font-size: var( --e-global-typography-8b7e80d-font-size ); font-weight: var( --e-global-typography-8b7e80d-font-weight ); letter-spacing: var( --e-global-typography-8b7e80d-letter-spacing ); word-spacing: var( --e-global-typography-8b7e80d-word-spacing );">These intercellular PPIs are quantified in-situ without the need for cell permeabilisation. Other interaction states that can be quantified include DNA-protein interactions.</span></p> </div> </div> </div> </div> <div class="elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-e407a32" data-id="e407a32" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-background-overlay"></div> <div class="elementor-element elementor-element-bb72ced elementor-widget elementor-widget-menu-anchor" data-id="bb72ced" data-element_type="widget" data-widget_type="menu-anchor.default"> <div class="elementor-widget-container"> <div id="PTMs" class="elementor-menu-anchor"></div> </div> </div> <div class="elementor-element elementor-element-c213126 elementor-widget elementor-widget-heading" data-id="c213126" data-element_type="widget" data-settings="{"_animation":"none","_animation_tablet":"none"}" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">Post-Translational Modifications<br>(PTMs)</h3> </div> </div> <div class="elementor-element elementor-element-1a36267 elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="1a36267" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-e191dc7 elementor-widget elementor-widget-text-editor" data-id="e191dc7" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Our intracellular PTM assays quantify events such as the phosphorylation or methylation states of intracellular proteins. The spatial mapping of these PTMs allows the user to quantify the functional states (e.g. activation) of proteins within samples. PTMs that can be quantified by QF-Pro® also include glycosylation and acetylation events. These readouts are particularly useful for gaining insights on intracellular signalling pathway dynamics and designing small molecule therapeutics.</p><p>Optimised biomarkers include Akt activation state, PD1 activation state and STAT3 (Y705 or S727) activation state quantification.</p> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-063c0eb elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="063c0eb" data-element_type="section" data-settings="{"background_background":"classic"}"> <div class="elementor-container elementor-column-gap-no"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d636af4" data-id="d636af4" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-background-overlay"></div> <div class="elementor-element elementor-element-b067dcc elementor-widget elementor-widget-menu-anchor" data-id="b067dcc" data-element_type="widget" data-widget_type="menu-anchor.default"> <div class="elementor-widget-container"> <div id="inmunooncology" class="elementor-menu-anchor"></div> </div> </div> <div class="elementor-element elementor-element-2ce2d49 elementor-widget elementor-widget-heading" data-id="2ce2d49" data-element_type="widget" data-settings="{"_animation":"none","_animation_tablet":"none"}" data-widget_type="heading.default"> <div class="elementor-widget-container"> <p class="elementor-heading-title elementor-size-default">Immuno-Oncology</p> </div> </div> <div class="elementor-element elementor-element-d0b91a9 elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="d0b91a9" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-8fd8dee elementor-widget elementor-widget-text-editor" data-id="8fd8dee" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Our technology has demonstrated a direct clinical value in the domain of immuno-oncology. Immune checkpoints, such as PD-1/PD-L1, provide a key mechanism to target cancer, by re-enabling the hosts immune system to fight and destroy malignant cells. However, only 12-20% of solid tumour patients respond to these therapies and the lack of a robust biomarker to indicate which patients will or will not respond to these immunotherapies only contributes to worsen this situation.</p> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-6323549 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="6323549" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-1ed5717" data-id="1ed5717" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-background-overlay"></div> <div class="elementor-element elementor-element-57414c6 elementor-widget elementor-widget-text-editor" data-id="57414c6" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Published in the Journal of Clinical Oncology in 2023, we have validated a QF-Pro® assay for the determination of PD-1/PD-L1 interaction state (functional checkpoint engagement) in non-small cell lung cancer (NSCLC). In this study of 188 patients, PD-1/PD-L1 interaction state measured by QF-Pro®, but not PD-L1 expression TPS, was highly predictive of patient outcome and response to immune checkpoint blockade treatments.</p><p>QF-Pro® identified that patients with a high PD-1/PD-L1 interaction state in their biopsy samples (as quantified by QF-Pro®) responded positively to immune checkpoint blockade, irrespective of their PD-L1 expression. This accounts for almost 25% of all NSCLC patients who would therefore not routinely be selected for therapy despite responding.</p> </div> </div> </div> </div> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-47e0e6f" data-id="47e0e6f" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-2f27ea8 elementor-arrows-position-outside elementor-pagination-position-outside elementor-widget elementor-widget-image-carousel" data-id="2f27ea8" data-element_type="widget" data-settings="{"slides_to_show":"1","navigation":"both","autoplay":"yes","pause_on_hover":"yes","pause_on_interaction":"yes","autoplay_speed":5000,"infinite":"yes","effect":"slide","speed":500}" data-widget_type="image-carousel.default"> <div class="elementor-widget-container"> <style>/*! elementor - v3.18.0 - 20-12-2023 */ .elementor-widget-image-carousel .swiper,.elementor-widget-image-carousel .swiper-container{position:static}.elementor-widget-image-carousel .swiper-container .swiper-slide figure,.elementor-widget-image-carousel .swiper .swiper-slide figure{line-height:inherit}.elementor-widget-image-carousel .swiper-slide{text-align:center}.elementor-image-carousel-wrapper:not(.swiper-container-initialized):not(.swiper-initialized) .swiper-slide{max-width:calc(100% / var(--e-image-carousel-slides-to-show, 3))}</style> <div class="elementor-image-carousel-wrapper swiper" dir="ltr"> <div class="elementor-image-carousel swiper-wrapper" aria-live="off"> <div class="swiper-slide" role="group" aria-roledescription="slide" aria-label="1 of 3"><figure class="swiper-slide-inner"><img decoding="async" class="swiper-slide-image" src="https://www.hawkbiosystems.com/wp-content/uploads/2024/05/immuno-oncology-2.png" alt="immuno-oncology-2" /></figure></div><div class="swiper-slide" role="group" aria-roledescription="slide" aria-label="2 of 3"><figure class="swiper-slide-inner"><img decoding="async" class="swiper-slide-image" src="https://www.hawkbiosystems.com/wp-content/uploads/2024/05/immuno-oncology-1.png" alt="immuno-oncology-1" /></figure></div><div class="swiper-slide" role="group" aria-roledescription="slide" aria-label="3 of 3"><figure class="swiper-slide-inner"><img decoding="async" class="swiper-slide-image" src="https://www.hawkbiosystems.com/wp-content/uploads/2024/05/immuno-oncology-3.jpg" alt="immuno-oncology-3" /></figure></div> </div> <div class="elementor-swiper-button elementor-swiper-button-prev" role="button" tabindex="0"> <i aria-hidden="true" class="eicon-chevron-left"></i> </div> <div class="elementor-swiper-button elementor-swiper-button-next" role="button" tabindex="0"> <i aria-hidden="true" class="eicon-chevron-right"></i> </div> <div class="swiper-pagination"></div> </div> </div> </div> </div> </div> </div> </section> <div class="elementor-element elementor-element-beae685 elementor-widget elementor-widget-text-editor" data-id="beae685" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Our QF-Pro® analyses were compared to classical PD-L1 expression scores (TPS) determined by IHC. PD-L1 TPS alone did not predict response to immune checkpoint inhibitors. Moreover, in this study, 22.5% of NSCLC patients with high PD-L1 expression but low PD-1/PD-L1 interaction state QF-Pro® read-outsfailed to respond to therapies. Thus, if QF-Pro® would be used to stratify NSCLC patients to IO treatments, it could significantly boost patient response rates to these treatments.</p> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-335e831 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="335e831" data-element_type="section" data-settings="{"background_background":"classic"}"> <div class="elementor-container elementor-column-gap-no"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-eaff4be" data-id="eaff4be" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-background-overlay"></div> <div class="elementor-element elementor-element-b72b8dd elementor-widget elementor-widget-menu-anchor" data-id="b72b8dd" data-element_type="widget" data-widget_type="menu-anchor.default"> <div class="elementor-widget-container"> <div id="casestudies" class="elementor-menu-anchor"></div> </div> </div> <div class="elementor-element elementor-element-1aaaff8 elementor-widget elementor-widget-heading" data-id="1aaaff8" data-element_type="widget" data-settings="{"_animation":"none","_animation_tablet":"none"}" data-widget_type="heading.default"> <div class="elementor-widget-container"> <p class="elementor-heading-title elementor-size-default">Case Studies</p> </div> </div> <div class="elementor-element elementor-element-06f5dbe elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="06f5dbe" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-329c0c5 elementor-widget elementor-widget-text-editor" data-id="329c0c5" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>QF-Pro® has also been validated in several clinical studies. Please view ‘Our Papers’ to see a selection of research outputs which have featured QF-Pro® technology.</p> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-f8601f9 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="f8601f9" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-c345e01" data-id="c345e01" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-4586d0f elementor-widget elementor-widget-heading" data-id="4586d0f" data-element_type="widget" data-settings="{"_animation":"none","_animation_tablet":"none"}" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Case Study 1</h2> </div> </div> <div class="elementor-element elementor-element-baa66a7 elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="baa66a7" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-34f52d9 elementor-widget elementor-widget-accordion" data-id="34f52d9" data-element_type="widget" data-widget_type="accordion.default"> <div class="elementor-widget-container"> <style>/*! elementor - v3.18.0 - 20-12-2023 */ .elementor-accordion{text-align:left}.elementor-accordion .elementor-accordion-item{border:1px solid #d5d8dc}.elementor-accordion .elementor-accordion-item+.elementor-accordion-item{border-top:none}.elementor-accordion .elementor-tab-title{margin:0;padding:15px 20px;font-weight:700;line-height:1;cursor:pointer;outline:none}.elementor-accordion .elementor-tab-title .elementor-accordion-icon{display:inline-block;width:1.5em}.elementor-accordion .elementor-tab-title .elementor-accordion-icon svg{width:1em;height:1em}.elementor-accordion .elementor-tab-title .elementor-accordion-icon.elementor-accordion-icon-right{float:right;text-align:right}.elementor-accordion .elementor-tab-title .elementor-accordion-icon.elementor-accordion-icon-left{float:left;text-align:left}.elementor-accordion .elementor-tab-title .elementor-accordion-icon .elementor-accordion-icon-closed{display:block}.elementor-accordion .elementor-tab-title .elementor-accordion-icon .elementor-accordion-icon-opened,.elementor-accordion .elementor-tab-title.elementor-active .elementor-accordion-icon-closed{display:none}.elementor-accordion .elementor-tab-title.elementor-active .elementor-accordion-icon-opened{display:block}.elementor-accordion .elementor-tab-content{display:none;padding:15px 20px;border-top:1px solid #d5d8dc}@media (max-width:767px){.elementor-accordion .elementor-tab-title{padding:12px 15px}.elementor-accordion .elementor-tab-title .elementor-accordion-icon{width:1.2em}.elementor-accordion .elementor-tab-content{padding:7px 15px}}.e-con-inner>.elementor-widget-accordion,.e-con>.elementor-widget-accordion{width:var(--container-widget-width);--flex-grow:var(--container-widget-flex-grow)}</style> <div class="elementor-accordion"> <div class="elementor-accordion-item"> <div id="elementor-tab-title-5551" class="elementor-tab-title" data-tab="1" role="button" aria-controls="elementor-tab-content-5551" aria-expanded="false"> <a class="elementor-accordion-title" tabindex="0">QF-Pro® could significantly boost immunotherapy response rates in lung cancer.</a> </div> <div id="elementor-tab-content-5551" class="elementor-tab-content elementor-clearfix" data-tab="1" role="region" aria-labelledby="elementor-tab-title-5551"><p><strong>QF-Pro</strong>®<strong> could predict patients’ response to immunotherapy in lung cancer.</strong> In a study published in <em>Journal of Clinical Oncology</em> in 2023, we showcased the ability of QF-Pro® to predict patient response to anti-PD-1/PD-L1 therapies by directly quantifying the interaction state of this immune checkpoint directly within patient biopsy samples. The results were ground-breaking. QF-Pro® could triple response rates and double overall survival rates compared to the current clinical gold-standard, PD-L1 TPS score. </p></div> </div> </div> </div> </div> </div> </div> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-ec3ba6c" data-id="ec3ba6c" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-820edeb elementor-widget elementor-widget-heading" data-id="820edeb" data-element_type="widget" data-settings="{"_animation":"none","_animation_tablet":"none"}" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Case Study 2</h2> </div> </div> <div class="elementor-element elementor-element-94b759f elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="94b759f" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-3ad7c65 elementor-widget elementor-widget-accordion" data-id="3ad7c65" data-element_type="widget" data-widget_type="accordion.default"> <div class="elementor-widget-container"> <div class="elementor-accordion"> <div class="elementor-accordion-item"> <div id="elementor-tab-title-6171" class="elementor-tab-title" data-tab="1" role="button" aria-controls="elementor-tab-content-6171" aria-expanded="false"> <a class="elementor-accordion-title" tabindex="0">QF-Pro® measures both PD-1/PD-L1 and CTLA-4/CD80 interaction states in lung metastases</a> </div> <div id="elementor-tab-content-6171" class="elementor-tab-content elementor-clearfix" data-tab="1" role="region" aria-labelledby="elementor-tab-title-6171"><p><strong>Determination of Interactive States of Immune Checkpoint Regulators in Lung Metastases after Radiofrequency Ablation. </strong>In a novel study, published in the journal Cancers, QF-Pro® quantified the interaction states of PD-1/PD-L1 and CTLA-4/CD80 in radiofrequency ablations (RFA)-treated lung metastases. This was the first time CTLA-4/CD80 interaction states had been spatially quantified in tissue samples, and showcased a potential route to select patients who would benefit from RFA and ICI dual therapy treatments. </p></div> </div> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-inner-section elementor-element elementor-element-8ca8884 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="8ca8884" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-d4d3cec" data-id="d4d3cec" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-700cea5 elementor-widget elementor-widget-heading" data-id="700cea5" data-element_type="widget" data-settings="{"_animation":"none","_animation_tablet":"none"}" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Case Study 3</h2> </div> </div> <div class="elementor-element elementor-element-3d00493 elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="3d00493" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-e7e6095 elementor-widget elementor-widget-accordion" data-id="e7e6095" data-element_type="widget" data-widget_type="accordion.default"> <div class="elementor-widget-container"> <div class="elementor-accordion"> <div class="elementor-accordion-item"> <div id="elementor-tab-title-2431" class="elementor-tab-title" data-tab="1" role="button" aria-controls="elementor-tab-content-2431" aria-expanded="false"> <a class="elementor-accordion-title" tabindex="0">QF-Pro® determine PD-1/PD-L1 interaction as a predictive biomarker in renal, skin and lung cancer.</a> </div> <div id="elementor-tab-content-2431" class="elementor-tab-content elementor-clearfix" data-tab="1" role="region" aria-labelledby="elementor-tab-title-2431"><p>QF-Pro® was applied, for the first time, to quantify the interaction states of PD-1/PD-L1 (in cells and FFPE tissues) and CTLA-4/CD80 (in cells). In this study, QF-Pro® technology was validated as a proof of concept for these two interactions showing great sensitivity and specificity. Moreover, QF-Pro® could predict patient overall survival in melanoma and lung cancer. Strikingly, in renal cancer, QF-Pro® outperformed the Proximity Ligation Assay (PLA) technology for the detection and quantification of these interactions. </p></div> </div> </div> </div> </div> </div> </div> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-fc6c144" data-id="fc6c144" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-9b7adf0 elementor-widget elementor-widget-heading" data-id="9b7adf0" data-element_type="widget" data-settings="{"_animation":"none","_animation_tablet":"none"}" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Case Study 4</h2> </div> </div> <div class="elementor-element elementor-element-8c17edd elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="8c17edd" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-4e5eceb elementor-widget elementor-widget-accordion" data-id="4e5eceb" data-element_type="widget" data-widget_type="accordion.default"> <div class="elementor-widget-container"> <div class="elementor-accordion"> <div class="elementor-accordion-item"> <div id="elementor-tab-title-8211" class="elementor-tab-title" data-tab="1" role="button" aria-controls="elementor-tab-content-8211" aria-expanded="false"> <a class="elementor-accordion-title" tabindex="0">QF-Pro® quantifies PD-1/PD-L1 interactions between melanoma cells and human immune cells in cell-membrane microarrays.</a> </div> <div id="elementor-tab-content-8211" class="elementor-tab-content elementor-clearfix" data-tab="1" role="region" aria-labelledby="elementor-tab-title-8211"><p>In this novel experimental set up, we spatially mapped the interaction state of PD-1/PD-L1 between melanoma cells and cell-membrane on tissue microarrays. This showcased the utility of membrane microarrays in combination with the quantification of spatial functional proteomics. </p></div> </div> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-inner-section elementor-element elementor-element-09096d9 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="09096d9" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-6edfd65" data-id="6edfd65" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-39e686b elementor-widget elementor-widget-heading" data-id="39e686b" data-element_type="widget" data-settings="{"_animation":"none","_animation_tablet":"none"}" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Case Study 5</h2> </div> </div> <div class="elementor-element elementor-element-1f0bec9 elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="1f0bec9" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-5c530af elementor-widget elementor-widget-accordion" data-id="5c530af" data-element_type="widget" data-widget_type="accordion.default"> <div class="elementor-widget-container"> <div class="elementor-accordion"> <div class="elementor-accordion-item"> <div id="elementor-tab-title-9681" class="elementor-tab-title" data-tab="1" role="button" aria-controls="elementor-tab-content-9681" aria-expanded="false"> <a class="elementor-accordion-title" tabindex="0">Akt/PKB Activation State Predicts Patient Outcome in ccRCC</a> </div> <div id="elementor-tab-content-9681" class="elementor-tab-content elementor-clearfix" data-tab="1" role="region" aria-labelledby="elementor-tab-title-9681"><p>QF-Pro® quantified the activation (phosphorylation) state of the oncoprotein Akt/PKB in clear cell renal cell carcinoma (ccRCC). This provided a prognostic tool capable of predicting overall survival in patients, with those patients with a higher activation state of Akt/PKB showing significantly poorer survival. Akt/PKB was originally discarded as a prognostic biomarker by the scientific community when only its expression was measured. This study exhibited the power of using functional spatial proteomics to map biomarker functionality within samples. </p></div> </div> </div> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-38c00be elementor-section-content-middle elementor-reverse-tablet elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="38c00be" data-element_type="section" data-settings="{"background_background":"classic"}"> <div class="elementor-background-overlay"></div> <div class="elementor-container elementor-column-gap-no"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0276c58" data-id="0276c58" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-f409239 elementor-widget elementor-widget-heading" data-id="f409239" data-element_type="widget" data-settings="{"_animation":"none","_animation_tablet":"none"}" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Discover our most recent publications</h2> </div> </div> <div class="elementor-element elementor-element-280a11b elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="280a11b" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-0585b19 elementor-mobile-align-center elementor-tablet-align-center elementor-align-center elementor-widget elementor-widget-button" data-id="0585b19" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="https://www.hawkbiosystems.com/papers/"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">Find out more</span> </span> </a> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-992af12 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="992af12" data-element_type="section" data-settings="{"background_background":"classic"}"> <div class="elementor-background-overlay"></div> <div class="elementor-container elementor-column-gap-no"> <div class="elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-56d119c" data-id="56d119c" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-background-overlay"></div> <div class="elementor-element elementor-element-2a4039c elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="2a4039c" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-21b2737 elementor-widget elementor-widget-heading" data-id="21b2737" data-element_type="widget" data-settings="{"_animation":"none","_animation_tablet":"none"}" data-widget_type="heading.default"> <div class="elementor-widget-container"> <p class="elementor-heading-title elementor-size-default">What is QF-Pro®?</p> </div> </div> <div class="elementor-element elementor-element-6065ac8 elementor-widget elementor-widget-text-editor" data-id="6065ac8" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Learn about Quantifying Functions in Proteins (QF-Pro®) and how our advanced bio-imaging assay can further your research outputs. Find out about how QF-Pro® works and understand which protein functional events it can quantify.</p> </div> </div> <div class="elementor-element elementor-element-253ed10 elementor-mobile-align-center elementor-tablet-align-center elementor-widget elementor-widget-button" data-id="253ed10" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="https://www.hawkbiosystems.com/what-is-qf-pro/"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">What is QF-Pro®?</span> </span> </a> </div> </div> </div> </div> </div> <div class="elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-e4c2a22" data-id="e4c2a22" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-background-overlay"></div> <div class="elementor-element elementor-element-86e1afb elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="86e1afb" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-cc40495 elementor-widget elementor-widget-heading" data-id="cc40495" data-element_type="widget" data-settings="{"_animation":"none","_animation_tablet":"none"}" data-widget_type="heading.default"> <div class="elementor-widget-container"> <p class="elementor-heading-title elementor-size-default">Validated Biomarkers</p> </div> </div> <div class="elementor-element elementor-element-36211cf elementor-widget elementor-widget-text-editor" data-id="36211cf" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Find out more about the wide range of QF-Pro® validated QF-Pro® assays that we offer, ranging from immune checkpoints to kinase activation states. 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for="form-field-name" class="elementor-field-label elementor-screen-only"> Name </label> <input size="1" type="text" name="form_fields[name]" id="form-field-name" class="elementor-field elementor-size-md elementor-field-textual" placeholder="Your name" required="required" aria-required="true"> </div> <div class="elementor-field-type-email elementor-field-group elementor-column elementor-field-group-email elementor-col-100 elementor-field-required"> <label for="form-field-email" class="elementor-field-label elementor-screen-only"> Email </label> <input size="1" type="email" name="form_fields[email]" id="form-field-email" class="elementor-field elementor-size-md elementor-field-textual" placeholder="Your email address" required="required" aria-required="true"> </div> <div class="elementor-field-group elementor-column elementor-field-type-submit elementor-col-50 e-form__buttons"> <button type="submit" class="elementor-button elementor-size-sm"> <span > <span class=" elementor-button-icon"> </span> <span class="elementor-button-text">Sign Up</span> </span> </button> </div> </div> </form> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-inner-section elementor-element elementor-element-436146c elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="436146c" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-c55fe19" data-id="c55fe19" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-79d0a7e elementor-widget elementor-widget-text-editor" data-id="79d0a7e" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><span style="color: #ffffff;"><a style="color: #ffffff;" href="https://www.hawkbiosystems.com">© Copyright HAWK Biosystems. All rights reserved.</a></span></p> </div> </div> <div class="elementor-element elementor-element-82e647c elementor-icon-list--layout-inline elementor-mobile-align-center elementor-align-center elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list" data-id="82e647c" data-element_type="widget" data-widget_type="icon-list.default"> <div class="elementor-widget-container"> <ul class="elementor-icon-list-items elementor-inline-items"> <li class="elementor-icon-list-item elementor-inline-item"> <a href="https://www.hawkbiosystems.com/legal-notice/" target="_blank"> <span class="elementor-icon-list-text">Legal Notice</span> </a> </li> <li class="elementor-icon-list-item elementor-inline-item"> <a href="https://www.hawkbiosystems.com/privacy-policy/" target="_blank"> <span class="elementor-icon-list-text">Privacy Policy</span> </a> </li> <li class="elementor-icon-list-item elementor-inline-item"> <a href="https://www.hawkbiosystems.com/cookies-policy/" target="_blank"> <span class="elementor-icon-list-text">Cookies Policy</span> </a> </li> </ul> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> </div>  <div id="cmplz-cookiebanner-container"><div class="cmplz-cookiebanner cmplz-hidden banner-1 cookie-banner optin cmplz-center cmplz-categories-type-view-preferences" aria-modal="true" data-nosnippet="true" role="dialog" aria-live="polite" aria-labelledby="cmplz-header-1-optin" aria-describedby="cmplz-message-1-optin"> <div class="cmplz-header"> <div class="cmplz-logo"></div> <div class="cmplz-title" id="cmplz-header-1-optin">This website uses cookies</div> <div class="cmplz-close" tabindex="0" role="button" aria-label="Close dialog"> <svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="times" class="svg-inline--fa fa-times fa-w-11" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 352 512"><path fill="currentColor" d="M242.72 256l100.07-100.07c12.28-12.28 12.28-32.19 0-44.48l-22.24-22.24c-12.28-12.28-32.19-12.28-44.48 0L176 189.28 75.93 89.21c-12.28-12.28-32.19-12.28-44.48 0L9.21 111.45c-12.28 12.28-12.28 32.19 0 44.48L109.28 256 9.21 356.07c-12.28 12.28-12.28 32.19 0 44.48l22.24 22.24c12.28 12.28 32.2 12.28 44.48 0L176 322.72l100.07 100.07c12.28 12.28 32.2 12.28 44.48 0l22.24-22.24c12.28-12.28 12.28-32.19 0-44.48L242.72 256z"></path></svg> </div> </div> <div class="cmplz-divider cmplz-divider-header"></div> <div class="cmplz-body"> <div class="cmplz-message" id="cmplz-message-1-optin">To provide the best experiences, we use technologies like cookies to store and/or access device information. 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pojo-a11y-btn-background-group pojo-a11y-btn-grayscale" data-action="grayscale" data-action-group="schema" tabindex="-1" role="button"> <span class="pojo-a11y-toolbar-icon"><svg version="1.1" xmlns="http://www.w3.org/2000/svg" width="1em" viewBox="0 0 448 448"><title>Grayscale</title><path fill="currentColor" d="M15.75 384h-15.75v-352h15.75v352zM31.5 383.75h-8v-351.75h8v351.75zM55 383.75h-7.75v-351.75h7.75v351.75zM94.25 383.75h-7.75v-351.75h7.75v351.75zM133.5 383.75h-15.5v-351.75h15.5v351.75zM165 383.75h-7.75v-351.75h7.75v351.75zM180.75 383.75h-7.75v-351.75h7.75v351.75zM196.5 383.75h-7.75v-351.75h7.75v351.75zM235.75 383.75h-15.75v-351.75h15.75v351.75zM275 383.75h-15.75v-351.75h15.75v351.75zM306.5 383.75h-15.75v-351.75h15.75v351.75zM338 383.75h-15.75v-351.75h15.75v351.75zM361.5 383.75h-15.75v-351.75h15.75v351.75zM408.75 383.75h-23.5v-351.75h23.5v351.75zM424.5 383.75h-8v-351.75h8v351.75zM448 384h-15.75v-352h15.75v352z"></path></svg></span><span class="pojo-a11y-toolbar-text">Grayscale</span> </a> </li> <li class="pojo-a11y-toolbar-item"> <a href="#" class="pojo-a11y-toolbar-link pojo-a11y-btn-background-group pojo-a11y-btn-high-contrast" data-action="high-contrast" data-action-group="schema" tabindex="-1" role="button"> <span class="pojo-a11y-toolbar-icon"><svg version="1.1" xmlns="http://www.w3.org/2000/svg" width="1em" viewBox="0 0 448 448"><title>High Contrast</title><path fill="currentColor" d="M192 360v-272c-75 0-136 61-136 136s61 136 136 136zM384 224c0 106-86 192-192 192s-192-86-192-192 86-192 192-192 192 86 192 192z"></path></svg></span><span class="pojo-a11y-toolbar-text">High Contrast</span> </a> </li> <li class="pojo-a11y-toolbar-item"> <a href="#" class="pojo-a11y-toolbar-link pojo-a11y-btn-background-group pojo-a11y-btn-negative-contrast" data-action="negative-contrast" data-action-group="schema" tabindex="-1" role="button"> <span class="pojo-a11y-toolbar-icon"><svg version="1.1" xmlns="http://www.w3.org/2000/svg" width="1em" viewBox="0 0 448 448"><title>Negative Contrast</title><path fill="currentColor" d="M416 240c-23.75-36.75-56.25-68.25-95.25-88.25 10 17 15.25 36.5 15.25 56.25 0 61.75-50.25 112-112 112s-112-50.25-112-112c0-19.75 5.25-39.25 15.25-56.25-39 20-71.5 51.5-95.25 88.25 42.75 66 111.75 112 192 112s149.25-46 192-112zM236 144c0-6.5-5.5-12-12-12-41.75 0-76 34.25-76 76 0 6.5 5.5 12 12 12s12-5.5 12-12c0-28.5 23.5-52 52-52 6.5 0 12-5.5 12-12zM448 240c0 6.25-2 12-5 17.25-46 75.75-130.25 126.75-219 126.75s-173-51.25-219-126.75c-3-5.25-5-11-5-17.25s2-12 5-17.25c46-75.5 130.25-126.75 219-126.75s173 51.25 219 126.75c3 5.25 5 11 5 17.25z"></path></svg></span><span class="pojo-a11y-toolbar-text">Negative Contrast</span> </a> </li> <li class="pojo-a11y-toolbar-item"> <a href="#" class="pojo-a11y-toolbar-link pojo-a11y-btn-background-group pojo-a11y-btn-light-background" data-action="light-background" data-action-group="schema" tabindex="-1" role="button"> <span class="pojo-a11y-toolbar-icon"><svg version="1.1" xmlns="http://www.w3.org/2000/svg" width="1em" viewBox="0 0 448 448"><title>Light Background</title><path fill="currentColor" d="M184 144c0 4.25-3.75 8-8 8s-8-3.75-8-8c0-17.25-26.75-24-40-24-4.25 0-8-3.75-8-8s3.75-8 8-8c23.25 0 56 12.25 56 40zM224 144c0-50-50.75-80-96-80s-96 30-96 80c0 16 6.5 32.75 17 45 4.75 5.5 10.25 10.75 15.25 16.5 17.75 21.25 32.75 46.25 35.25 74.5h57c2.5-28.25 17.5-53.25 35.25-74.5 5-5.75 10.5-11 15.25-16.5 10.5-12.25 17-29 17-45zM256 144c0 25.75-8.5 48-25.75 67s-40 45.75-42 72.5c7.25 4.25 11.75 12.25 11.75 20.5 0 6-2.25 11.75-6.25 16 4 4.25 6.25 10 6.25 16 0 8.25-4.25 15.75-11.25 20.25 2 3.5 3.25 7.75 3.25 11.75 0 16.25-12.75 24-27.25 24-6.5 14.5-21 24-36.75 24s-30.25-9.5-36.75-24c-14.5 0-27.25-7.75-27.25-24 0-4 1.25-8.25 3.25-11.75-7-4.5-11.25-12-11.25-20.25 0-6 2.25-11.75 6.25-16-4-4.25-6.25-10-6.25-16 0-8.25 4.5-16.25 11.75-20.5-2-26.75-24.75-53.5-42-72.5s-25.75-41.25-25.75-67c0-68 64.75-112 128-112s128 44 128 112z"></path></svg></span><span class="pojo-a11y-toolbar-text">Light Background</span> </a> </li> <li class="pojo-a11y-toolbar-item"> <a href="#" class="pojo-a11y-toolbar-link pojo-a11y-btn-links-underline" data-action="links-underline" data-action-group="toggle" tabindex="-1" role="button"> <span class="pojo-a11y-toolbar-icon"><svg version="1.1" xmlns="http://www.w3.org/2000/svg" width="1em" viewBox="0 0 448 448"><title>Links Underline</title><path fill="currentColor" d="M364 304c0-6.5-2.5-12.5-7-17l-52-52c-4.5-4.5-10.75-7-17-7-7.25 0-13 2.75-18 8 8.25 8.25 18 15.25 18 28 0 13.25-10.75 24-24 24-12.75 0-19.75-9.75-28-18-5.25 5-8.25 10.75-8.25 18.25 0 6.25 2.5 12.5 7 17l51.5 51.75c4.5 4.5 10.75 6.75 17 6.75s12.5-2.25 17-6.5l36.75-36.5c4.5-4.5 7-10.5 7-16.75zM188.25 127.75c0-6.25-2.5-12.5-7-17l-51.5-51.75c-4.5-4.5-10.75-7-17-7s-12.5 2.5-17 6.75l-36.75 36.5c-4.5 4.5-7 10.5-7 16.75 0 6.5 2.5 12.5 7 17l52 52c4.5 4.5 10.75 6.75 17 6.75 7.25 0 13-2.5 18-7.75-8.25-8.25-18-15.25-18-28 0-13.25 10.75-24 24-24 12.75 0 19.75 9.75 28 18 5.25-5 8.25-10.75 8.25-18.25zM412 304c0 19-7.75 37.5-21.25 50.75l-36.75 36.5c-13.5 13.5-31.75 20.75-50.75 20.75-19.25 0-37.5-7.5-51-21.25l-51.5-51.75c-13.5-13.5-20.75-31.75-20.75-50.75 0-19.75 8-38.5 22-52.25l-22-22c-13.75 14-32.25 22-52 22-19 0-37.5-7.5-51-21l-52-52c-13.75-13.75-21-31.75-21-51 0-19 7.75-37.5 21.25-50.75l36.75-36.5c13.5-13.5 31.75-20.75 50.75-20.75 19.25 0 37.5 7.5 51 21.25l51.5 51.75c13.5 13.5 20.75 31.75 20.75 50.75 0 19.75-8 38.5-22 52.25l22 22c13.75-14 32.25-22 52-22 19 0 37.5 7.5 51 21l52 52c13.75 13.75 21 31.75 21 51z"></path></svg></span><span class="pojo-a11y-toolbar-text">Links Underline</span> </a> </li> <li class="pojo-a11y-toolbar-item"> <a href="#" class="pojo-a11y-toolbar-link pojo-a11y-btn-readable-font" data-action="readable-font" data-action-group="toggle" tabindex="-1" role="button"> <span class="pojo-a11y-toolbar-icon"><svg version="1.1" xmlns="http://www.w3.org/2000/svg" width="1em" viewBox="0 0 448 448"><title>Readable Font</title><path fill="currentColor" d="M181.25 139.75l-42.5 112.5c24.75 0.25 49.5 1 74.25 1 4.75 0 9.5-0.25 14.25-0.5-13-38-28.25-76.75-46-113zM0 416l0.5-19.75c23.5-7.25 49-2.25 59.5-29.25l59.25-154 70-181h32c1 1.75 2 3.5 2.75 5.25l51.25 120c18.75 44.25 36 89 55 133 11.25 26 20 52.75 32.5 78.25 1.75 4 5.25 11.5 8.75 14.25 8.25 6.5 31.25 8 43 12.5 0.75 4.75 1.5 9.5 1.5 14.25 0 2.25-0.25 4.25-0.25 6.5-31.75 0-63.5-4-95.25-4-32.75 0-65.5 2.75-98.25 3.75 0-6.5 0.25-13 1-19.5l32.75-7c6.75-1.5 20-3.25 20-12.5 0-9-32.25-83.25-36.25-93.5l-112.5-0.5c-6.5 14.5-31.75 80-31.75 89.5 0 19.25 36.75 20 51 22 0.25 4.75 0.25 9.5 0.25 14.5 0 2.25-0.25 4.5-0.5 6.75-29 0-58.25-5-87.25-5-3.5 0-8.5 1.5-12 2-15.75 2.75-31.25 3.5-47 3.5z"></path></svg></span><span class="pojo-a11y-toolbar-text">Readable Font</span> </a> </li> <li class="pojo-a11y-toolbar-item"> <a href="#" class="pojo-a11y-toolbar-link pojo-a11y-btn-reset" data-action="reset" tabindex="-1" role="button"> <span class="pojo-a11y-toolbar-icon"><svg version="1.1" xmlns="http://www.w3.org/2000/svg" width="1em" viewBox="0 0 448 448"><title>Reset</title><path fill="currentColor" d="M384 224c0 105.75-86.25 192-192 192-57.25 0-111.25-25.25-147.75-69.25-2.5-3.25-2.25-8 0.5-10.75l34.25-34.5c1.75-1.5 4-2.25 6.25-2.25 2.25 0.25 4.5 1.25 5.75 3 24.5 31.75 61.25 49.75 101 49.75 70.5 0 128-57.5 128-128s-57.5-128-128-128c-32.75 0-63.75 12.5-87 34.25l34.25 34.5c4.75 4.5 6 11.5 3.5 17.25-2.5 6-8.25 10-14.75 10h-112c-8.75 0-16-7.25-16-16v-112c0-6.5 4-12.25 10-14.75 5.75-2.5 12.75-1.25 17.25 3.5l32.5 32.25c35.25-33.25 83-53 132.25-53 105.75 0 192 86.25 192 192z"></path></svg></span> <span class="pojo-a11y-toolbar-text">Reset</span> </a> </li> </ul> <ul class="pojo-a11y-toolbar-items pojo-a11y-links"> <li class="pojo-a11y-toolbar-item"> <a href="https://www.hawkbiosystems.com/sitemap_index.xml" class="pojo-a11y-toolbar-link pojo-a11y-link-sitemap" tabindex="-1" role="button"> <span class="pojo-a11y-toolbar-icon"><svg version="1.1" xmlns="http://www.w3.org/2000/svg" width="1em" viewBox="0 0 448 448"><title>Sitemap</title><path fill="currentColor" d="M448 312v80c0 13.25-10.75 24-24 24h-80c-13.25 0-24-10.75-24-24v-80c0-13.25 10.75-24 24-24h24v-48h-128v48h24c13.25 0 24 10.75 24 24v80c0 13.25-10.75 24-24 24h-80c-13.25 0-24-10.75-24-24v-80c0-13.25 10.75-24 24-24h24v-48h-128v48h24c13.25 0 24 10.75 24 24v80c0 13.25-10.75 24-24 24h-80c-13.25 0-24-10.75-24-24v-80c0-13.25 10.75-24 24-24h24v-48c0-17.5 14.5-32 32-32h128v-48h-24c-13.25 0-24-10.75-24-24v-80c0-13.25 10.75-24 24-24h80c13.25 0 24 10.75 24 24v80c0 13.25-10.75 24-24 24h-24v48h128c17.5 0 32 14.5 32 32v48h24c13.25 0 24 10.75 24 24z"></path></svg></span><span class="pojo-a11y-toolbar-text">Sitemap</span> </a> </li> </ul> </div> </div> </nav> </body> </html>