Non Hodgkins Lymphoma - Cancer Science

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It occurs when the body produces abnormal lymphocytes, a type of white blood cell, that multiply and accumulate in the lymph nodes and other tissues. NHL can occur at any age and is more common than <a href="https://cancerscience.net/about/index/hodgkin's-lymphoma" title="Hodgkin's lymphoma" target="_blank">Hodgkin's lymphoma</a>.</div><div><a href="https://cancerscience.net/knowledgebase/what-are-the-risk-factors" title="What are the Risk Factors?"><h3>What are the Risk Factors?</h3></a>Several factors can increase the risk of developing NHL, including a weakened immune system, certain infections, age, gender, and exposure to certain chemicals. People with conditions such as <a href="https://cancerscience.net/about/index/hiv/aids" title="HIV/AIDS" target="_blank">HIV/AIDS</a> or those taking immunosuppressant drugs are at higher risk. Infections with viruses like <a href="https://cancerscience.net/about/index/epstein-barr-virus" title="Epstein-Barr virus" target="_blank">Epstein-Barr virus</a> or bacteria like <a href="https://cancerscience.net/about/index/helicobacter-pylori" title="Helicobacter pylori" target="_blank">Helicobacter pylori</a> have also been associated with NHL.</div><div><a href="https://cancerscience.net/knowledgebase/how-is-non-hodgkin-s-lymphoma-diagnosed" title="How is Non-Hodgkin's Lymphoma Diagnosed?"><h3>How is Non-Hodgkin's Lymphoma Diagnosed?</h3></a>Diagnosis typically involves a combination of physical exams, blood tests, imaging studies, and a biopsy. A <a href="https://cancerscience.net/about/index/lymph-node-biopsy" title="lymph node biopsy" target="_blank">lymph node biopsy</a> is the most definitive method for diagnosing NHL, as it allows for examination of lymph node tissue under a microscope. Other tests might include <a href="https://cancerscience.net/about/index/ct-scans" title="CT scans" target="_blank">CT scans</a>, <a href="https://cancerscience.net/about/index/pet-scans" title="PET scans" target="_blank">PET scans</a>, or <a href="https://cancerscience.net/about/index/mri" title="MRI" target="_blank">MRI</a> to assess the spread of the disease.</div><div><a href="https://cancerscience.net/knowledgebase/what-are-the-symptoms" title="What are the Symptoms?"><h3>What are the Symptoms?</h3></a>Symptoms of NHL can vary depending on the type and stage of the disease but often include swollen lymph nodes, fever, night sweats, unexplained weight loss, fatigue, and abdominal pain or swelling. It is important to note that these symptoms can be caused by other, less serious conditions, so a thorough medical evaluation is essential.</div><div><a href="https://cancerscience.net/knowledgebase/what-are-the-types-of-non-hodgkin-s-lymphoma" title="What are the Types of Non-Hodgkin's Lymphoma?"><h3>What are the Types of Non-Hodgkin's Lymphoma?</h3></a>NHL is categorized into various types based on the characteristics of the cancer cells. The two main types are <a href="https://cancerscience.net/about/index/b-cell-lymphomas" title="B-cell lymphomas" target="_blank">B-cell lymphomas</a> and <a href="https://cancerscience.net/about/index/t-cell-lymphomas" title="T-cell lymphomas" target="_blank">T-cell lymphomas</a>. B-cell lymphomas are more common and include subtypes like <a href="https://cancerscience.net/about/index/diffuse-large-b-cell-lymphoma" title="diffuse large B-cell lymphoma" target="_blank">diffuse large B-cell lymphoma</a> and <a href="https://cancerscience.net/about/index/follicular-lymphoma" title="follicular lymphoma" target="_blank">follicular lymphoma</a>. T-cell lymphomas are less common and include subtypes like <a href="https://cancerscience.net/about/index/peripheral-t-cell-lymphoma" title="peripheral T-cell lymphoma" target="_blank">peripheral T-cell lymphoma</a> and <a href="https://cancerscience.net/about/index/cutaneous-t-cell-lymphoma" title="cutaneous T-cell lymphoma" target="_blank">cutaneous T-cell lymphoma</a>.</div><div><a href="https://cancerscience.net/knowledgebase/what-treatment-options-are-available" title="What Treatment Options are Available?"><h3>What Treatment Options are Available?</h3></a>Treatment for NHL depends on the type, stage, and location of the cancer, as well as the patient's overall health. Common treatments include <a href="https://cancerscience.net/about/index/chemotherapy" title="chemotherapy" target="_blank">chemotherapy</a>, <a href="https://cancerscience.net/about/index/radiation-therapy" title="radiation therapy" target="_blank">radiation therapy</a>, targeted therapy, and <a href="https://cancerscience.net/about/index/immunotherapy" title="immunotherapy" target="_blank">immunotherapy</a>. In some cases, a <a href="https://cancerscience.net/about/index/stem-cell-transplant" title="stem cell transplant" target="_blank">stem cell transplant</a> may be considered. The choice of treatment is often guided by the specific characteristics of the lymphoma and the patient's preferences.</div><div><h3>What is the Prognosis for Patients with Non-Hodgkin's Lymphoma?</h3>The prognosis for NHL can vary widely depending on the type and stage of the lymphoma, the patient's age and overall health, and how well the cancer responds to treatment. Some types of NHL are aggressive and require immediate treatment, while others are indolent and may not need treatment right away. Advances in treatment have improved the outlook for many patients with NHL.</div><div><a href="https://cancerscience.net/knowledgebase/what-are-the-latest-research-and-developments" title="What are the Latest Research and Developments?"><h3>What are the Latest Research and Developments?</h3></a>Research in NHL is ongoing, with studies focusing on better understanding the biology of the disease, improving existing treatments, and developing new therapies. Recent developments include the use of <a href="https://cancerscience.net/about/index/car-t-cell-therapy" title="CAR T-cell therapy" target="_blank">CAR T-cell therapy</a>, which involves genetically modifying a patient's T-cells to target lymphoma cells more effectively. Clinical trials are also exploring new drugs and combinations of treatments to improve outcomes for patients with NHL.</div><div><h3>Conclusion</h3>Non-Hodgkin's lymphoma is a diverse group of cancers with varying prognoses and treatment options. Early diagnosis and advances in treatment have significantly improved outcomes for many patients. Ongoing research continues to enhance our understanding of NHL, leading to more effective and personalized treatment strategies.</div></div> </div> <div id="recent_papers"> <br><hr /><br><h2 class="heading1">Relevant Publications</h2> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/39172105" target='_blank' title="A rare case report of hemophagocytic lymphohistiocytosis secondary to pure eythroid leukemia in a person living with HIV.">A rare case report of hemophagocytic lymphohistiocytosis secondary to pure eythroid leukemia in a person living with HIV.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38486446" target='_blank' title="Flow cytometry is a sensitive technique to assess marrow involvement by B cell non-Hodgkins lymphoma.">Flow cytometry is a sensitive technique to assess marrow involvement by B cell non-Hodgkins lymphoma.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38636814" target='_blank' title="Noncoding RNAs in B cell non-Hodgkins lymphoma.">Noncoding RNAs in B cell non-Hodgkins lymphoma.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38899351" target='_blank' title="Anti-CD19 chimeric antigen receptor T-cell therapy has less efficacy in Richter transformation than in large B-cell lymphoma and transformed low-grade B-cell lymphoma.">Anti-CD19 chimeric antigen receptor T-cell therapy has less efficacy in Richter transformation than in large B-cell lymphoma and transformed low-grade B-cell lymphoma.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38544655" target='_blank' title="When Sarcomas Mimic Lymphomas: A BCOR-Rearranged Sarcoma Case Report.">When Sarcomas Mimic Lymphomas: A BCOR-Rearranged Sarcoma Case Report.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38339400" target='_blank' title="Long-Term Results of IFRT vs. ISRT in Infradiaphragmal Fields in Aggressive Non-Hodgkins\'s Lymphoma Patients-A Single Centre Experience.">Long-Term Results of IFRT vs. ISRT in Infradiaphragmal Fields in Aggressive Non-Hodgkins\'s Lymphoma Patients-A Single Centre Experience.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38857048" target='_blank' title="Cancer Incidence Trends in Successive Social Generations in the US.">Cancer Incidence Trends in Successive Social Generations in the US.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38198763" target='_blank' title="Management of Patients undergoing CAR-T cell therapy in Germany.">Management of Patients undergoing CAR-T cell therapy in Germany.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/36660562" target='_blank' title="Diagnostic difficulties of antero-superior mediastinal masses with cardiac infiltration. 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