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class="firstHeading mw-first-heading"><span class="mw-page-title-main">Becaplermin</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. 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mw-list-item"><a href="https://it.wikipedia.org/wiki/Becaplermin" title="Becaplermin – Italian" lang="it" hreflang="it" data-title="Becaplermin" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%AC%E0%AD%87%E0%AC%95%E0%AC%BE%E0%AC%AA%E0%AD%8D%E0%AC%B2%E0%AD%87%E0%AC%B0%E0%AC%AE%E0%AC%BF%E0%AC%A8" title="ବେକାପ୍ଲେରମିନ – Odia" lang="or" hreflang="or" data-title="ବେକାପ୍ଲେରମିନ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Bekaplermin" title="Bekaplermin – Polish" lang="pl" hreflang="pl" data-title="Bekaplermin" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Becaplermina" title="Becaplermina – Portuguese" lang="pt" hreflang="pt" data-title="Becaplermina" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%91%D0%B5%D0%BA%D0%B0%D0%BF%D0%BB%D0%B5%D1%80%D0%BC%D0%B8%D0%BD" title="Бекаплермин – Russian" lang="ru" hreflang="ru" data-title="Бекаплермин" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Bekaplermin" title="Bekaplermin – Serbian" lang="sr" hreflang="sr" data-title="Bekaplermin" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Bekaplermin" title="Bekaplermin – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Bekaplermin" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-te mw-list-item"><a href="https://te.wikipedia.org/wiki/%E0%B0%AC%E0%B1%86%E0%B0%95%E0%B0%BE%E0%B0%AA%E0%B1%8D%E0%B0%B2%E0%B0%B0%E0%B1%8D%E0%B0%AE%E0%B0%BF%E0%B0%A8%E0%B1%8D" title="బెకాప్లర్మిన్ – Telugu" lang="te" hreflang="te" data-title="బెకాప్లర్మిన్" data-language-autonym="తెలుగు" data-language-local-name="Telugu" class="interlanguage-link-target"><span>తెలుగు</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%91%D0%B5%D0%BA%D0%B0%D0%BF%D0%BB%D0%B5%D1%80%D0%BC%D1%96%D0%BD" title="Бекаплермін – Ukrainian" lang="uk" hreflang="uk" data-title="Бекаплермін" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q2313188#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon 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class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Pharmaceutical drug</div> <p class="mw-empty-elt"> </p> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Becaplermin">Becaplermin</span></caption><tbody><tr><th colspan="2" class="infobox-header" style="background:#ddd">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Regranex</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/cdi/becaplermin.html">Consumer Drug Information</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></th><td class="infobox-data"><span title="medlineplus.gov"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a699049.html">a699049</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data"><a href="/wiki/Topical_administration" class="mw-redirect" title="Topical administration">Topical</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"><ul><li><a href="/wiki/ATC_code_A01" title="ATC code A01">A01AD08</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=A01AD08">WHO</a></span>) , <a href="/wiki/ATC_code_D03" title="ATC code D03">D03AX06</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=D03AX06">WHO</a></span>)</li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="United States">US</abbr>:</small> <a href="/wiki/Prescription_drug" title="Prescription drug">℞-only</a><sup id="cite_ref-Regranex_FDA_label_1-0" class="reference"><a href="#cite_note-Regranex_FDA_label-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=165101-51-9">165101-51-9</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB00102">DB00102</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li>none</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/1B56C968OA">1B56C968OA</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/ChEMBL1201556">ChEMBL1201556</a></span><sup> <span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID70858772">DTXSID70858772</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q2313188#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><td colspan="2" class="infobox-below"><style data-mw-deduplicate="TemplateStyles:r886047488">.mw-parser-output .nobold{font-weight:normal}</style><span class="nobold"> <sup><span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span><span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup> <a href="/wiki/Wikipedia:WikiProject_Chemicals/Chembox_validation" title="Wikipedia:WikiProject Chemicals/Chembox validation">(what is this?)</a></span><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r886047488"><span class="nobold">  <span class="reflink plainlinks nourlexpansion"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=Special:ComparePages&rev1=458285090&page2=Becaplermin">(verify)</a></span></span></td></tr></tbody></table> <p><b>Becaplermin</b>, sold under the brand name <b>Regranex</b>, is a <a href="/wiki/Cicatrizant" class="mw-redirect" title="Cicatrizant">cicatrizant</a>, available as a <a href="/wiki/Topical_gels" title="Topical gels">topical gel</a>. Regranex is a human <a href="/wiki/Platelet-derived_growth_factor" title="Platelet-derived growth factor">platelet-derived growth factor</a> indicated along with good wound care for the treatment of lower extremity diabetic neuropathic ulcers.<sup id="cite_ref-Regranex_FDA_label_1-1" class="reference"><a href="#cite_note-Regranex_FDA_label-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> It is also known as "platelet-derived growth factor BB".<sup id="cite_ref-Regranex_FDA_label_1-2" class="reference"><a href="#cite_note-Regranex_FDA_label-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Medical_uses">Medical uses</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Becaplermin&action=edit&section=1" title="Edit section: Medical uses"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Becaplermin is used for the treatment of <a href="/wiki/Diabetic" class="mw-redirect" title="Diabetic">diabetic</a> <a href="/wiki/Foot_ulcer" class="mw-redirect" title="Foot ulcer">foot ulcers</a>.<sup id="cite_ref-pmid11849120_2-0" class="reference"><a href="#cite_note-pmid11849120-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Studies of becaplermin showed that when used with good wound care, complete healing significantly increased and the ulcers healed on average 6 weeks faster.<sup id="cite_ref-pmid9589248_3-0" class="reference"><a href="#cite_note-pmid9589248-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Pharmacoeconomic studies reinforce the cost effectiveness of becaplermin as an adjunct to good wound care.<sup id="cite_ref-pmid16464208_4-0" class="reference"><a href="#cite_note-pmid16464208-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p><p>The amount of becaplermin to be applied will vary depending upon the size of the ulcer area. Becaplermin should be stored in the refrigerator.<sup id="cite_ref-Regranex_FDA_label_1-3" class="reference"><a href="#cite_note-Regranex_FDA_label-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Analysis of healing human wounds showed that PDGF-BB induces fibroblast proliferation and differentiation and was found to increase healing in patients with decreased healing capacity, such as people living with diabetes. <sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Contraindications">Contraindications</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Becaplermin&action=edit&section=2" title="Edit section: Contraindications"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Becaplermin must not be used at the site of a <a href="/wiki/Skin_cancer" title="Skin cancer">skin cancer</a>.<sup id="cite_ref-Drugs.com_6-0" class="reference"><a href="#cite_note-Drugs.com-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Adverse_effects">Adverse effects</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Becaplermin&action=edit&section=3" title="Edit section: Adverse effects"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The most common side effects in clinical studies were <a href="/wiki/Erythematous_rash" class="mw-redirect" title="Erythematous rash">erythematous rashes</a>.<sup id="cite_ref-Drugs.com_6-1" class="reference"><a href="#cite_note-Drugs.com-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>A <a href="/wiki/Boxed_warning" title="Boxed warning">boxed warning</a> has been added to the US FDA prescription label to describe an increase rate of death from <a href="/wiki/Cancer" title="Cancer">cancer</a> when three or more tubes are used.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Becaplermin&action=edit&section=4" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-Regranex_FDA_label-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-Regranex_FDA_label_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Regranex_FDA_label_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Regranex_FDA_label_1-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-Regranex_FDA_label_1-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fd2c7d21-7b07-4ab3-8983-816ab3223771">"Regranex- becaplermin gel"</a>. <i>DailyMed</i>. 11 December 2023<span class="reference-accessdate">. Retrieved <span class="nowrap">26 October</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=DailyMed&rft.atitle=Regranex-+becaplermin+gel&rft.date=2023-12-11&rft_id=https%3A%2F%2Fdailymed.nlm.nih.gov%2Fdailymed%2FdrugInfo.cfm%3Fsetid%3Dfd2c7d21-7b07-4ab3-8983-816ab3223771&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABecaplermin" class="Z3988"></span></span> </li> <li id="cite_note-pmid11849120-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11849120_2-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNagaiEmbil2002" class="citation journal cs1">Nagai MK, Embil JM (February 2002). "Becaplermin: recombinant platelet derived growth factor, a new treatment for healing diabetic foot ulcers". <i>Expert Opinion on Biological Therapy</i>. <b>2</b> (2): 211–8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1517%2F14712598.2.2.211">10.1517/14712598.2.2.211</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11849120">11849120</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:28408255">28408255</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Expert+Opinion+on+Biological+Therapy&rft.atitle=Becaplermin%3A+recombinant+platelet+derived+growth+factor%2C+a+new+treatment+for+healing+diabetic+foot+ulcers&rft.volume=2&rft.issue=2&rft.pages=211-8&rft.date=2002-02&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A28408255%23id-name%3DS2CID&rft_id=info%3Apmid%2F11849120&rft_id=info%3Adoi%2F10.1517%2F14712598.2.2.211&rft.aulast=Nagai&rft.aufirst=MK&rft.au=Embil%2C+JM&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABecaplermin" class="Z3988"></span></span> </li> <li id="cite_note-pmid9589248-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid9589248_3-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWiemanSmiellSu1998" class="citation journal cs1">Wieman TJ, Smiell JM, Su Y (May 1998). "Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers. A phase III randomized placebo-controlled double-blind study". <i>Diabetes Care</i>. <b>21</b> (5): 822–7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2337%2Fdiacare.21.5.822">10.2337/diacare.21.5.822</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9589248">9589248</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:20595962">20595962</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Diabetes+Care&rft.atitle=Efficacy+and+safety+of+a+topical+gel+formulation+of+recombinant+human+platelet-derived+growth+factor-BB+%28becaplermin%29+in+patients+with+chronic+neuropathic+diabetic+ulcers.+A+phase+III+randomized+placebo-controlled+double-blind+study&rft.volume=21&rft.issue=5&rft.pages=822-7&rft.date=1998-05&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A20595962%23id-name%3DS2CID&rft_id=info%3Apmid%2F9589248&rft_id=info%3Adoi%2F10.2337%2Fdiacare.21.5.822&rft.aulast=Wieman&rft.aufirst=TJ&rft.au=Smiell%2C+JM&rft.au=Su%2C+Y&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABecaplermin" class="Z3988"></span></span> </li> <li id="cite_note-pmid16464208-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid16464208_4-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPerssonWillisOdegaardApelqvist2000" class="citation journal cs1">Persson U, Willis M, Odegaard K, Apelqvist J (2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1046%2Fj.1524-4733.2000.36027.x">"The cost-effectiveness of treating diabetic lower extremity ulcers with becaplermin (Regranex): a core model with an application using Swedish cost data"</a>. <i>Value in Health</i>. <b>3</b> (Suppl 1): 39–46. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1046%2Fj.1524-4733.2000.36027.x">10.1046/j.1524-4733.2000.36027.x</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16464208">16464208</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Value+in+Health&rft.atitle=The+cost-effectiveness+of+treating+diabetic+lower+extremity+ulcers+with+becaplermin+%28Regranex%29%3A+a+core+model+with+an+application+using+Swedish+cost+data&rft.volume=3&rft.issue=Suppl+1&rft.pages=39-46&rft.date=2000&rft_id=info%3Adoi%2F10.1046%2Fj.1524-4733.2000.36027.x&rft_id=info%3Apmid%2F16464208&rft.aulast=Persson&rft.aufirst=U&rft.au=Willis%2C+M&rft.au=Odegaard%2C+K&rft.au=Apelqvist%2C+J&rft_id=https%3A%2F%2Fdoi.org%2F10.1046%252Fj.1524-4733.2000.36027.x&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABecaplermin" class="Z3988"></span></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-5">^</a></b></span> <span class="reference-text">Heldin CH, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev. 1999;79:1283-1316.</span> </li> <li id="cite_note-Drugs.com-6"><span class="mw-cite-backlink">^ <a href="#cite_ref-Drugs.com_6-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Drugs.com_6-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/pro/regranex.html">FDA Professional Drug Information</a></span> for Regranex.</span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-7">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWaknine2008" class="citation web cs1">Waknine Y (9 June 2008). <a rel="nofollow" class="external text" href="http://www.medscape.com/viewarticle/575748?sssdmh=dm1.359512&scr=ddd">"Diabetic Ulcer Gel Gets Black Box Warning"</a>. <i>Medscape</i>.</cite><span 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title="Prophylaxis">prophylaxis</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dectaflur" title="Dectaflur">Dectaflur</a></li> <li><a href="/wiki/Olaflur" title="Olaflur">Olaflur</a></li> <li><a href="/wiki/Sodium_fluoride" title="Sodium fluoride">Sodium fluoride</a></li> <li><a href="/wiki/Sodium_monofluorophosphate" title="Sodium monofluorophosphate">Sodium monofluorophosphate</a></li> <li><a href="/wiki/Tin(II)_fluoride" title="Tin(II) fluoride">Stannous fluoride</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Infection" title="Infection">Infection</a> and <a href="/wiki/Antiseptic" title="Antiseptic">antiseptics</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Amphotericin_B" title="Amphotericin B">Amphotericin B</a></li> <li><a href="/wiki/Benzoxonium_chloride" title="Benzoxonium chloride">Benzoxonium chloride</a></li> <li><a href="/wiki/Chlorhexidine_gluconate" class="mw-redirect" title="Chlorhexidine gluconate">Chlorhexidine</a></li> <li><a href="/wiki/Chlortetracycline" title="Chlortetracycline">Chlortetracycline</a></li> <li><a href="/wiki/Clotrimazole" title="Clotrimazole">Clotrimazole</a></li> <li><a href="/wiki/Cetylpyridinium_chloride" title="Cetylpyridinium chloride">Cetylpyridinium chloride</a></li> <li><a href="/wiki/Domiphen_bromide" title="Domiphen bromide">Domiphen bromide</a></li> <li><a href="/wiki/Doxycycline" title="Doxycycline">Doxycycline</a></li> <li><a href="/wiki/Eugenol" title="Eugenol">Eugenol</a></li> <li><a href="/wiki/Hexetidine" title="Hexetidine">Hexetidine</a></li> <li><a href="/wiki/Hydrogen_peroxide" title="Hydrogen peroxide">Hydrogen peroxide</a></li> <li><a href="/wiki/Mepartricin" title="Mepartricin">Mepartricin</a></li> <li><a href="/wiki/Metronidazole" title="Metronidazole">Metronidazole</a></li> <li><a href="/wiki/Miconazole" title="Miconazole">Miconazole</a></li> <li><a href="/wiki/Minocycline" title="Minocycline">Minocycline</a></li> <li><a href="/wiki/Natamycin" title="Natamycin">Natamycin</a></li> <li><a href="/wiki/Neomycin" title="Neomycin">Neomycin</a></li> <li><a href="/wiki/Oxyquinoline" class="mw-redirect" title="Oxyquinoline">Oxyquinoline</a></li> <li><a href="/wiki/Polynoxylin" title="Polynoxylin">Polynoxylin</a></li> <li><a href="/wiki/Sodium_perborate" title="Sodium perborate">Sodium perborate</a></li> <li><a href="/wiki/Tetracycline" title="Tetracycline">Tetracycline</a></li> <li><a href="/wiki/Tibezonium_iodide" title="Tibezonium iodide">Tibezonium iodide</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Corticosteroid" title="Corticosteroid">Corticosteroids</a><br /> (<a href="/wiki/Glucocorticoid" title="Glucocorticoid">Glucocorticoids</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dexamethasone" title="Dexamethasone">Dexamethasone</a></li> <li><a href="/wiki/Cortisol" title="Cortisol">Hydrocortisone</a></li> <li><a href="/wiki/Triamcinolone" title="Triamcinolone">Triamcinolone</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Amlexanox" title="Amlexanox">Amlexanox</a></li> <li><a href="/wiki/Aspirin" title="Aspirin">Acetylsalicylic acid</a></li> <li><a class="mw-selflink selflink">Becaplermin</a></li> <li><a href="/wiki/Benzydamine" title="Benzydamine">Benzydamine</a></li> <li><a href="/wiki/Epinephrine" class="mw-redirect" title="Epinephrine">Epinephrine</a>/<a href="/wiki/Adrenalone" title="Adrenalone">Adrenalone</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Preparations_for_treatment_of_wounds_and_ulcers_(D03)" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Preparations_for_treatment_of_wounds_and_ulcers" title="Template:Preparations for treatment of wounds and ulcers"><abbr title="View this template">v</abbr></a></li><li 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navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Epichlorohydrin" title="Epichlorohydrin">epichlorohydrin</a>:</i> <a href="/wiki/Cadexomer_iodine" title="Cadexomer iodine">Cadexomer iodine</a></li> <li><a href="/wiki/Crilanomer" title="Crilanomer">Crilanomer</a></li> <li><a href="/wiki/Dextranomer" title="Dextranomer">Dextranomer</a></li></ul> <ul><li><i><a href="/wiki/Pantothenic_acid" title="Pantothenic acid">B5</a>:</i> <a href="/wiki/Pantothenic_acid" title="Pantothenic acid">Calcium pantothenate</a></li> <li><a href="/wiki/Panthenol" title="Panthenol">Dexpanthenol</a></li></ul> <ul><li><i><a href="/wiki/Nitrate" title="Nitrate">nitrate</a>:</i> <a href="/wiki/Medical_use_of_nitroglycerin" class="mw-redirect" title="Medical use of nitroglycerin">Nitroglycerin</a></li> <li><a href="/wiki/Isosorbide_dinitrate" title="Isosorbide dinitrate">Isosorbide dinitrate</a></li></ul> <ul><li>other: <a class="mw-selflink selflink">Becaplermin</a></li> <li><a href="/wiki/Beremagene_geperpavec" title="Beremagene geperpavec">Beremagene geperpavec</a></li> <li><a href="/wiki/Birch_triterpenes" title="Birch triterpenes">Betulae cortex</a></li> <li><a href="/wiki/Centella_asiatica" title="Centella asiatica">Centella asiatica herba</a></li> <li><a href="/wiki/Enoxolone" title="Enoxolone">Enoxolone</a></li> <li><a href="/wiki/Hyaluronan" class="mw-redirect" title="Hyaluronan">Hyaluronic acid</a></li> <li><a href="/wiki/Ketanserin" title="Ketanserin">Ketanserin</a></li> <li><a href="/wiki/Nepidermin" title="Nepidermin">Nepidermin</a></li> <li><a href="/wiki/Tetrachlorodecaoxide" title="Tetrachlorodecaoxide">Sodium chlorite (tetrachlorodecaoxide)</a></li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li> <li><a href="/wiki/Trolamine" class="mw-redirect" title="Trolamine">Trolamine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Proteolytic enzymes</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bromelain_(pharmacology)" title="Bromelain (pharmacology)">Bromelain (anacaulase)</a></li> <li><a href="/wiki/Clostridiopeptidase" class="mw-redirect" title="Clostridiopeptidase">Clostridiopeptidase</a></li> <li><a href="/wiki/Trypsin" title="Trypsin">Trypsin</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Growth_factor_receptor_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Growth_factor_receptor_modulators" title="Template:Growth factor receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Growth_factor_receptor_modulators" title="Template talk:Growth factor receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Growth_factor_receptor_modulators" title="Special:EditPage/Template:Growth factor receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Growth_factor_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Growth_factor_receptor" title="Growth factor receptor">Growth factor receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Angiopoietin_receptor" title="Angiopoietin receptor">Angiopoietin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Angiopoietin_1" title="Angiopoietin 1">Angiopoietin 1</a></li> <li><a href="/wiki/Angiopoietin_4" class="mw-redirect" title="Angiopoietin 4">Angiopoietin 4</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Angiopoietin_2" class="mw-redirect" title="Angiopoietin 2">Angiopoietin 2</a></li> <li><a href="/w/index.php?title=Angiopoietin_3&action=edit&redlink=1" class="new" title="Angiopoietin 3 (page does not exist)">Angiopoietin 3</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/wiki/Rebastinib" class="mw-redirect" title="Rebastinib">Rebastinib</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Evinacumab" title="Evinacumab">Evinacumab</a> (against angiopoietin 3)</li> <li><a href="/wiki/Nesvacumab" title="Nesvacumab">Nesvacumab</a> (against angiopoietin 2)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Ciliary_neurotrophic_factor_receptor" title="Ciliary neurotrophic factor receptor">CNTF</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Axokine" class="mw-redirect" title="Axokine">Axokine</a></li> <li><a href="/wiki/Ciliary_neurotrophic_factor_receptor" title="Ciliary neurotrophic factor receptor">CNTF</a></li> <li><a href="/w/index.php?title=Dapiclermin&action=edit&redlink=1" class="new" title="Dapiclermin (page does not exist)">Dapiclermin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">EGF (ErbB)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">EGF<br /><small>(ErbB1/HER1)</small></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Amphiregulin" title="Amphiregulin">Amphiregulin</a></li> <li><a href="/wiki/Betacellulin" title="Betacellulin">Betacellulin</a></li> <li><a href="/wiki/Epidermal_growth_factor" title="Epidermal growth factor">EGF (urogastrone)</a></li> <li><a href="/wiki/Epigen" title="Epigen">Epigen</a></li> <li><a href="/wiki/Epiregulin" title="Epiregulin">Epiregulin</a></li> <li><a href="/wiki/Heparin-binding_EGF-like_growth_factor" title="Heparin-binding EGF-like growth factor">Heparin-binding EGF-like growth factor (HB-EGF)</a></li> <li><a href="/wiki/Murodermin" title="Murodermin">Murodermin</a></li> <li><a href="/wiki/Nepidermin" title="Nepidermin">Nepidermin</a></li> <li><a href="/wiki/Transforming_growth_factor_alpha" class="mw-redirect" title="Transforming growth factor alpha">Transforming growth factor alpha (TGFα)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Afatinib" title="Afatinib">Afatinib</a></li> <li><a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/wiki/Brigatinib" title="Brigatinib">Brigatinib</a></li> <li><a href="/wiki/Canertinib" title="Canertinib">Canertinib</a></li> <li><a href="/wiki/Dacomitinib" title="Dacomitinib">Dacomitinib</a></li> <li><a href="/wiki/Erlotinib" title="Erlotinib">Erlotinib</a></li> <li><a href="/wiki/Gefitinib" title="Gefitinib">Gefitinib</a></li> <li><a href="/wiki/Grandinin" title="Grandinin">Grandinin</a></li> <li><a href="/wiki/Icotinib" title="Icotinib">Icotinib</a></li> <li><a href="/wiki/Lapatinib" title="Lapatinib">Lapatinib</a></li> <li><a href="/wiki/Neratinib" title="Neratinib">Neratinib</a></li> <li><a href="/wiki/Osimertinib" title="Osimertinib">Osimertinib</a></li> <li><a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li> <li><a href="/w/index.php?title=WHI-P_154&action=edit&redlink=1" class="new" title="WHI-P 154 (page does not exist)">WHI-P 154</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Cetuximab" title="Cetuximab">Cetuximab</a></li> <li><a href="/w/index.php?title=Depatuxizumab&action=edit&redlink=1" class="new" title="Depatuxizumab (page does not exist)">Depatuxizumab</a></li> <li><a href="/wiki/Depatuxizumab_mafodotin" title="Depatuxizumab mafodotin">Depatuxizumab mafodotin</a></li> <li><a href="/wiki/Futuximab" title="Futuximab">Futuximab</a></li> <li><a href="/wiki/Imgatuzumab" title="Imgatuzumab">Imgatuzumab</a></li> <li><a href="/wiki/Matuzumab" title="Matuzumab">Matuzumab</a></li> <li><a href="/wiki/Necitumumab" title="Necitumumab">Necitumumab</a></li> <li><a href="/wiki/Nimotuzumab" title="Nimotuzumab">Nimotuzumab</a></li> <li><a href="/wiki/Panitumumab" title="Panitumumab">Panitumumab</a></li> <li><a href="/wiki/Zalutumumab" title="Zalutumumab">Zalutumumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/HER2/neu" class="mw-redirect" title="HER2/neu">ErbB2/HER2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <i>Unknown/none</i></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Ertumaxomab" title="Ertumaxomab">Ertumaxomab</a></li> <li><a href="/wiki/Pertuzumab" title="Pertuzumab">Pertuzumab</a></li> <li><a href="/wiki/Trastuzumab" title="Trastuzumab">Trastuzumab</a></li> <li><a href="/wiki/Trastuzumab_deruxtecan" title="Trastuzumab deruxtecan">Trastuzumab deruxtecan</a></li> <li><a href="/w/index.php?title=Trastuzumab_duocarmazine&action=edit&redlink=1" class="new" title="Trastuzumab duocarmazine (page does not exist)">Trastuzumab duocarmazine</a></li> <li><a href="/wiki/Trastuzumab_emtansine" title="Trastuzumab emtansine">Trastuzumab emtansine</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Afatinib" title="Afatinib">Afatinib</a></li> <li><a href="/wiki/Lapatinib" title="Lapatinib">Lapatinib</a></li> <li><a href="/wiki/Mubritinib" title="Mubritinib">Mubritinib</a></li> <li><a href="/wiki/Neratinib" title="Neratinib">Neratinib</a></li> <li><a href="/wiki/Tucatinib" title="Tucatinib">Tucatinib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/HER3" class="mw-redirect" title="HER3">ErbB3/HER3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Neuregulin" title="Neuregulin">Neuregulins (heregulins)</a> (<a href="/wiki/Neuregulin-1" class="mw-redirect" title="Neuregulin-1">1</a>, <a href="/wiki/NRG2" class="mw-redirect" title="NRG2">2</a>, <a href="/wiki/CSPG5" title="CSPG5">6 (neuroglycan C)</a>)</li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Duligotumab" class="mw-redirect" title="Duligotumab">Duligotumab</a></li> <li><a href="/wiki/Patritumab" title="Patritumab">Patritumab</a></li> <li><a href="/wiki/Seribantumab" title="Seribantumab">Seribantumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/HER4" class="mw-redirect" title="HER4">ErbB4/HER4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Betacellulin" title="Betacellulin">Betacellulin</a></li> <li><a href="/wiki/Epigen" title="Epigen">Epigen</a></li> <li><a href="/wiki/Heparin-binding_EGF-like_growth_factor" title="Heparin-binding EGF-like growth factor">Heparin-binding EGF-like growth factor (HB-EGF)</a></li> <li><a href="/wiki/Neuregulin" title="Neuregulin">Neuregulins (heregulins)</a> (<a href="/wiki/Neuregulin-1" class="mw-redirect" title="Neuregulin-1">1</a>, <a href="/wiki/NRG2" class="mw-redirect" title="NRG2">2</a>, <a href="/wiki/NRG3" class="mw-redirect" title="NRG3">3</a>, <a href="/wiki/NRG4" class="mw-redirect" title="NRG4">4</a>, <a href="/w/index.php?title=Tomoregulin&action=edit&redlink=1" class="new" title="Tomoregulin (page does not exist)">5 (tomoregulin, TMEFF)</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor" title="Fibroblast growth factor receptor">FGF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_1" title="Fibroblast growth factor receptor 1">FGFR1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF3" title="FGF3">3</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF5" title="FGF5">5</a>, <a href="/wiki/FGF6" title="FGF6">6</a>, <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF10" title="FGF10">10 (KGF2)</a>, <a href="/wiki/FGF20" title="FGF20">20</a>)</li> <li><a href="/w/index.php?title=Repifermin&action=edit&redlink=1" class="new" title="Repifermin (page does not exist)">Repifermin</a></li> <li><a href="/wiki/Selpercatinib" title="Selpercatinib">Selpercatinib</a></li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li> <li><a href="/w/index.php?title=Velafermin&action=edit&redlink=1" class="new" title="Velafermin (page does not exist)">Velafermin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_2" title="Fibroblast growth factor receptor 2">FGFR2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF3" title="FGF3">3</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF5" title="FGF5">5</a>, <a href="/wiki/FGF6" title="FGF6">6</a>, <a href="/wiki/FGF7" title="FGF7">7</a> (<a href="/wiki/Keratinocyte_growth_factor" title="Keratinocyte growth factor">KGF</a>), <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF9" title="FGF9">9</a>, <a href="/wiki/FGF10" title="FGF10">10 (KGF2)</a>, <a href="/wiki/FGF17" title="FGF17">17</a>, <a href="/wiki/FGF18" title="FGF18">18</a>, <a href="/wiki/FGF22" title="FGF22">22</a>)</li> <li><a href="/wiki/Palifermin" title="Palifermin">Palifermin</a></li> <li><a href="/w/index.php?title=Repifermin&action=edit&redlink=1" class="new" title="Repifermin (page does not exist)">Repifermin</a></li> <li><a href="/wiki/Selpercatinib" title="Selpercatinib">Selpercatinib</a></li> <li><a href="/wiki/Sprifermin" title="Sprifermin">Sprifermin</a></li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=Aprutumab&action=edit&redlink=1" class="new" title="Aprutumab (page does not exist)">Aprutumab</a></li> <li><a href="/w/index.php?title=Aprutumab_ixadotin&action=edit&redlink=1" class="new" title="Aprutumab ixadotin (page does not exist)">Aprutumab ixadotin</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Infigratinib" title="Infigratinib">Infigratinib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_3" title="Fibroblast growth factor receptor 3">FGFR3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF9" title="FGF9">9</a>, <a href="/wiki/FGF18" title="FGF18">18</a>, <a href="/wiki/FGF23" class="mw-redirect" title="FGF23">23</a>)</li> <li><a href="/wiki/Selpercatinib" title="Selpercatinib">Selpercatinib</a></li> <li><a href="/wiki/Sprifermin" title="Sprifermin">Sprifermin</a></li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Burosumab" title="Burosumab">Burosumab</a> (against FGF23)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_4" title="Fibroblast growth factor receptor 4">FGFR4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF6" title="FGF6">6</a>, <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF9" title="FGF9">9</a>, <a href="/wiki/FGF19" title="FGF19">19</a>)</li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/FGF15/19" title="FGF15/19">FGF15/19</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Hepatocyte_growth_factor_receptor" title="Hepatocyte growth factor receptor">HGF (c-Met)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Fosgonimeton" title="Fosgonimeton">Fosgonimeton</a></li> <li><a href="/wiki/Hepatocyte_growth_factor" title="Hepatocyte growth factor">Hepatocyte growth factor</a></li></ul> <ul><li><i>Potentiators:</i> <a href="/wiki/Dihexa" title="Dihexa">Dihexa (PNB-0408)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AM7_(drug)&action=edit&redlink=1" class="new" title="AM7 (drug) (page does not exist)">AM7</a></li> <li><a href="/w/index.php?title=AMG-458&action=edit&redlink=1" class="new" title="AMG-458 (page does not exist)">AMG-458</a></li> <li><a href="/w/index.php?title=Amuvatinib&action=edit&redlink=1" class="new" title="Amuvatinib (page does not exist)">Amuvatinib</a></li> <li><a href="/w/index.php?title=BMS-777607&action=edit&redlink=1" class="new" title="BMS-777607 (page does not exist)">BMS-777607</a></li> <li><a href="/wiki/Cabozantinib" title="Cabozantinib">Cabozantinib</a></li> <li><a href="/wiki/Capmatinib" title="Capmatinib">Capmatinib</a></li> <li><a href="/wiki/Crizotinib" title="Crizotinib">Crizotinib</a></li> <li><a href="/wiki/Foretinib" title="Foretinib">Foretinib</a></li> <li><a href="/w/index.php?title=Golvatinib&action=edit&redlink=1" class="new" title="Golvatinib (page does not exist)">Golvatinib</a></li> <li><a href="/w/index.php?title=INCB28060&action=edit&redlink=1" class="new" title="INCB28060 (page does not exist)">INCB28060</a></li> <li><a href="/w/index.php?title=JNJ-38877605&action=edit&redlink=1" class="new" title="JNJ-38877605 (page does not exist)">JNJ-38877605</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/w/index.php?title=MK-2461&action=edit&redlink=1" class="new" title="MK-2461 (page does not exist)">MK-2461</a></li> <li><a href="/w/index.php?title=PF-04217903&action=edit&redlink=1" class="new" title="PF-04217903 (page does not exist)">PF-04217903</a></li> <li><a href="/w/index.php?title=PF-2341066&action=edit&redlink=1" class="new" title="PF-2341066 (page does not exist)">PF-2341066</a></li> <li><a href="/w/index.php?title=PHA-665752&action=edit&redlink=1" class="new" title="PHA-665752 (page does not exist)">PHA-665752</a></li> <li><a href="/w/index.php?title=SU-11274&action=edit&redlink=1" class="new" title="SU-11274 (page does not exist)">SU-11274</a></li> <li><a href="/wiki/Tivantinib" title="Tivantinib">Tivantinib</a></li> <li><a href="/wiki/Volitinib" class="mw-redirect" title="Volitinib">Volitinib</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Emibetuzumab" title="Emibetuzumab">Emibetuzumab</a></li> <li><a href="/wiki/Ficlatuzumab" title="Ficlatuzumab">Ficlatuzumab</a></li> <li><a href="/wiki/Flanvotumab" title="Flanvotumab">Flanvotumab</a></li> <li><a href="/wiki/Onartuzumab" title="Onartuzumab">Onartuzumab</a></li> <li><a href="/wiki/Rilotumumab" title="Rilotumumab">Rilotumumab</a></li> <li><a href="/w/index.php?title=Telisotuzumab&action=edit&redlink=1" class="new" title="Telisotuzumab (page does not exist)">Telisotuzumab</a></li> <li><a href="/wiki/Telisotuzumab_vedotin" title="Telisotuzumab vedotin">Telisotuzumab vedotin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Somatomedin_receptor" title="Somatomedin receptor">IGF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Insulin-like_growth_factor_1_receptor" title="Insulin-like growth factor 1 receptor">IGF-1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Des(1-3)IGF-1" title="Des(1-3)IGF-1">des(1-3)IGF-1</a></li> <li><a href="/wiki/Insulin-like_growth_factor_1" title="Insulin-like growth factor 1">Insulin-like growth factor-1 (somatomedin C)</a></li> <li><a href="/wiki/IGF-1_LR3" title="IGF-1 LR3">IGF-1 LR3</a></li> <li><a href="/wiki/Insulin-like_growth_factor_2" title="Insulin-like growth factor 2">Insulin-like growth factor-2 (somatomedin A)</a></li> <li><a href="/wiki/Insulin" title="Insulin">Insulin</a></li> <li><a href="/wiki/Mecasermin" title="Mecasermin">Mecasermin</a></li> <li><a href="/wiki/Mecasermin_rinfabate" title="Mecasermin rinfabate">Mecasermin rinfabate</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=BMS-754807&action=edit&redlink=1" class="new" title="BMS-754807 (page does not exist)">BMS-754807</a></li> <li><a href="/wiki/Linsitinib" title="Linsitinib">Linsitinib</a></li> <li><a href="/w/index.php?title=NVP-ADW742&action=edit&redlink=1" class="new" title="NVP-ADW742 (page does not exist)">NVP-ADW742</a></li> <li><a href="/w/index.php?title=NVP-AEW541&action=edit&redlink=1" class="new" title="NVP-AEW541 (page does not exist)">NVP-AEW541</a></li> <li><a href="/w/index.php?title=OSl-906&action=edit&redlink=1" class="new" title="OSl-906 (page does not exist)">OSl-906</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=AVE-1642&action=edit&redlink=1" class="new" title="AVE-1642 (page does not exist)">AVE-1642</a></li> <li><a href="/wiki/Cixutumumab" title="Cixutumumab">Cixutumumab</a></li> <li><a href="/wiki/Dalotuzumab" title="Dalotuzumab">Dalotuzumab</a></li> <li><a href="/wiki/Figitumumab" title="Figitumumab">Figitumumab</a></li> <li><a href="/wiki/Ganitumab" title="Ganitumab">Ganitumab</a></li> <li><a href="/wiki/Robatumumab" title="Robatumumab">Robatumumab</a></li> <li><a href="/w/index.php?title=R1507&action=edit&redlink=1" class="new" title="R1507 (page does not exist)">R1507</a></li> <li><a href="/wiki/Teprotumumab" title="Teprotumumab">Teprotumumab</a></li> <li><a href="/w/index.php?title=Xentuzumab&action=edit&redlink=1" class="new" title="Xentuzumab (page does not exist)">Xentuzumab</a> (against IGF-1 and IGF-2)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Insulin-like_growth_factor_2_receptor" title="Insulin-like growth factor 2 receptor">IGF-2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Insulin-like_growth_factor_2" title="Insulin-like growth factor 2">Insulin-like growth factor-2 (somatomedin A)</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Dusigitumab" title="Dusigitumab">Dusigitumab</a></li> <li><a href="/w/index.php?title=Xentuzumab&action=edit&redlink=1" class="new" title="Xentuzumab (page does not exist)">Xentuzumab</a> (against IGF-1 and IGF-2)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Binding proteins:</i> <a href="/wiki/Insulin-like_growth_factor-binding_protein" title="Insulin-like growth factor-binding protein">IGFBP</a> (<a href="/wiki/IGFBP1" title="IGFBP1">1</a>, <a href="/wiki/IGFBP2" title="IGFBP2">2</a>, <a href="/wiki/IGFBP3" title="IGFBP3">3</a>, <a href="/wiki/IGFBP4" title="IGFBP4">4</a>, <a href="/wiki/IGFBP5" title="IGFBP5">5</a>, <a href="/wiki/IGFBP6" title="IGFBP6">6</a>, <a href="/wiki/IGFBP7" title="IGFBP7">7</a>)</li></ul> <ul><li><i>Cleavage products/derivatives with unknown target:</i> <a href="/w/index.php?title=Glypromate&action=edit&redlink=1" class="new" title="Glypromate (page does not exist)">Glypromate (GPE, (1-3)IGF-1)</a></li> <li><a href="/wiki/Trofinetide" title="Trofinetide">Trofinetide</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Low-affinity_nerve_growth_factor_receptor" title="Low-affinity nerve growth factor receptor">LNGF (p75<sup>NTR</sup>)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Brain-derived_neurotrophic_factor" title="Brain-derived neurotrophic factor">BDNF</a></li> <li><a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/BNN-27" title="BNN-27">BNN-27</a></li> <li><a href="/wiki/Cenegermin" title="Cenegermin">Cenegermin</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li> <li><a href="/wiki/Dehydroepiandrosterone_sulfate" title="Dehydroepiandrosterone sulfate">DHEA-S</a></li> <li><a href="/wiki/Nerve_growth_factor" title="Nerve growth factor">NGF</a></li> <li><a href="/wiki/Neurotrophin-3" title="Neurotrophin-3">NT-3</a></li> <li><a href="/wiki/Neurotrophin-4" title="Neurotrophin-4">NT-4</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=ALE-0540&action=edit&redlink=1" class="new" title="ALE-0540 (page does not exist)">ALE-0540</a></li> <li><a href="/wiki/Dexamethasone" title="Dexamethasone">Dexamethasone</a></li> <li><a href="/w/index.php?title=EVT-901&action=edit&redlink=1" class="new" title="EVT-901 (page does not exist)">EVT-901 (SAR-127963)</a></li> <li><a href="/wiki/Testosterone" title="Testosterone">Testosterone</a></li></ul> <ul><li><i>Antibodies:</i> <i>Against NGF:</i> <a href="/w/index.php?title=ABT-110&action=edit&redlink=1" class="new" title="ABT-110 (page does not exist)">ABT-110 (PG110)</a></li> <li><a href="/w/index.php?title=ASP-6294&action=edit&redlink=1" class="new" title="ASP-6294 (page does not exist)">ASP-6294</a></li> <li><a href="/wiki/Fasinumab" title="Fasinumab">Fasinumab</a></li> <li><a href="/wiki/Frunevetmab" title="Frunevetmab">Frunevetmab</a></li> <li><a href="/wiki/Fulranumab" title="Fulranumab">Fulranumab</a></li> <li><a href="/w/index.php?title=MEDI-578&action=edit&redlink=1" class="new" title="MEDI-578 (page does not exist)">MEDI-578</a></li> <li><a href="/w/index.php?title=Ranevetmab&action=edit&redlink=1" class="new" title="Ranevetmab (page does not exist)">Ranevetmab</a></li> <li><a href="/wiki/Tanezumab" title="Tanezumab">Tanezumab</a></li></ul> <ul><li><i>Aptamers:</i> <i>Against NGF:</i> <a href="/w/index.php?title=RBM-004&action=edit&redlink=1" class="new" title="RBM-004 (page does not exist)">RBM-004</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/w/index.php?title=LEVI-04&action=edit&redlink=1" class="new" title="LEVI-04 (page does not exist)">LEVI-04 (p75<sup>NTR</sup>-Fc)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Platelet-derived_growth_factor_receptor" title="Platelet-derived growth factor receptor">PDGF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a class="mw-selflink selflink">Becaplermin</a></li> <li><a href="/wiki/Platelet-derived_growth_factor" title="Platelet-derived growth factor">Platelet-derived growth factor</a> (<a href="/wiki/PDGFA" title="PDGFA">A</a>, <a href="/wiki/PDGFB" title="PDGFB">B</a>, <a href="/wiki/PDGFC" title="PDGFC">C</a>, <a href="/wiki/PDGFD" title="PDGFD">D</a>)</li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/wiki/Avapritinib" title="Avapritinib">Avapritinib</a></li> <li><a href="/wiki/Axitinib" title="Axitinib">Axitinib</a></li> <li><a href="/wiki/Crenolanib" title="Crenolanib">Crenolanib</a></li> <li><a href="/wiki/Imatinib" title="Imatinib">Imatinib</a></li> <li><a href="/wiki/Lenvatinib" title="Lenvatinib">Lenvatinib</a></li> <li><a href="/wiki/Masitinib" title="Masitinib">Masitinib</a></li> <li><a href="/wiki/Motesanib" title="Motesanib">Motesanib</a></li> <li><a href="/wiki/Nintedanib" title="Nintedanib">Nintedanib</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Radotinib" title="Radotinib">Radotinib</a></li> <li><a href="/wiki/Quizartinib" title="Quizartinib">Quizartinib</a></li> <li><a href="/wiki/Ripretinib" title="Ripretinib">Ripretinib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Toceranib" title="Toceranib">Toceranib</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Olaratumab" title="Olaratumab">Olaratumab</a></li> <li><a href="/wiki/Ramucirumab" title="Ramucirumab">Ramucirumab</a></li> <li><a href="/wiki/Tovetumab" title="Tovetumab">Tovetumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/RET_proto-oncogene" title="RET proto-oncogene">RET (GFL)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B11" class="mw-redirect" title="GFRα1">GFRα1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Glial_cell_line-derived_neurotrophic_factor" title="Glial cell line-derived neurotrophic factor">Glial cell line-derived neurotrophic factor (GDNF)</a></li> <li><a href="/w/index.php?title=Liatermin&action=edit&redlink=1" class="new" title="Liatermin (page does not exist)">Liatermin</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B12" class="mw-redirect" title="GFRα2">GFRα2</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Neurturin" title="Neurturin">Neurturin (NRTN)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B13" class="mw-redirect" title="GFRα3">GFRα3</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Artemin" title="Artemin">Artemin (ARTN)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B14" class="mw-redirect" title="GFRα4">GFRα4</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Persephin" title="Persephin">Persephin (PSPN)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CD117" class="mw-redirect" title="CD117">SCF (c-Kit)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Ancestim" title="Ancestim">Ancestim</a></li> <li><a href="/wiki/Stem_cell_factor" title="Stem cell factor">Stem cell factor</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/wiki/Axitinib" title="Axitinib">Axitinib</a></li> <li><a href="/wiki/Dasatinib" title="Dasatinib">Dasatinib</a></li> <li><a href="/wiki/Imatinib" title="Imatinib">Imatinib</a></li> <li><a href="/wiki/Masitinib" title="Masitinib">Masitinib</a></li> <li><a href="/wiki/Nilotinib" title="Nilotinib">Nilotinib</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Quizartinib" title="Quizartinib">Quizartinib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Toceranib" title="Toceranib">Toceranib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Transforming_growth_factor_beta_receptor" class="mw-redirect" title="Transforming growth factor beta receptor">TGFβ</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:TGF%CE%B2_receptor_superfamily_modulators" title="Template:TGFβ receptor superfamily modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Trk_receptor" title="Trk receptor">Trk</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TrkA_receptor" class="mw-redirect" title="TrkA receptor">TrkA</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Amitriptyline" title="Amitriptyline">Amitriptyline</a></li> <li><a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/BNN-27" title="BNN-27">BNN-27</a></li> <li><a href="/wiki/Cenegermin" title="Cenegermin">Cenegermin</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li> <li><a href="/wiki/Dehydroepiandrosterone_sulfate" title="Dehydroepiandrosterone sulfate">DHEA-S</a></li> <li><a href="/w/index.php?title=Gambogic_amide&action=edit&redlink=1" class="new" title="Gambogic amide (page does not exist)">Gambogic amide</a></li> <li><a href="/wiki/Nerve_growth_factor" title="Nerve growth factor">NGF</a></li> <li><a href="/wiki/Tavilermide" title="Tavilermide">Tavilermide</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=ALE-0540&action=edit&redlink=1" class="new" title="ALE-0540 (page does not exist)">ALE-0540</a></li> <li><a href="/wiki/Dexamethasone" title="Dexamethasone">Dexamethasone</a></li> <li><a href="/wiki/FX007" class="mw-redirect" title="FX007">FX007</a></li> <li><a href="/wiki/Testosterone" title="Testosterone">Testosterone</a></li></ul> <ul><li><i>Negative allosteric modulators:</i> <a href="/w/index.php?title=VM-902A&action=edit&redlink=1" class="new" title="VM-902A (page does not exist)">VM-902A</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AZD-6918&action=edit&redlink=1" class="new" title="AZD-6918 (page does not exist)">AZD-6918</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/w/index.php?title=CH-7057288&action=edit&redlink=1" class="new" title="CH-7057288 (page does not exist)">CH-7057288</a></li> <li><a href="/w/index.php?title=DS-6051&action=edit&redlink=1" class="new" title="DS-6051 (page does not exist)">DS-6051</a></li> <li><a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a></li> <li><a href="/w/index.php?title=GZ-389988&action=edit&redlink=1" class="new" title="GZ-389988 (page does not exist)">GZ-389988</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/wiki/Larotrectinib" title="Larotrectinib">Larotrectinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/w/index.php?title=Milciclib&action=edit&redlink=1" class="new" title="Milciclib (page does not exist)">Milciclib</a></li> <li><a href="/w/index.php?title=ONO-4474&action=edit&redlink=1" class="new" title="ONO-4474 (page does not exist)">ONO-4474</a></li> <li><a href="/w/index.php?title=ONO-5390556&action=edit&redlink=1" class="new" title="ONO-5390556 (page does not exist)">ONO-5390556</a></li> <li><a href="/w/index.php?title=PLX-7486&action=edit&redlink=1" class="new" title="PLX-7486 (page does not exist)">PLX-7486</a></li> <li><a href="/wiki/Rebastinib" class="mw-redirect" title="Rebastinib">Rebastinib</a></li> <li><a href="/w/index.php?title=SNA-120&action=edit&redlink=1" class="new" title="SNA-120 (page does not exist)">SNA-120 (pegylated K252a)</a>)</li></ul> <ul><li><i>Antibodies:</i> <i>Against TrkA:</i> <a href="/w/index.php?title=GBR-900&action=edit&redlink=1" class="new" title="GBR-900 (page does not exist)">GBR-900</a>; <i>Against NGF:</i> <a href="/w/index.php?title=ABT-110&action=edit&redlink=1" class="new" title="ABT-110 (page does not exist)">ABT-110 (PG110)</a></li> <li><a href="/w/index.php?title=ASP-6294&action=edit&redlink=1" class="new" title="ASP-6294 (page does not exist)">ASP-6294</a></li> <li><a href="/wiki/Fasinumab" title="Fasinumab">Fasinumab</a></li> <li><a href="/wiki/Frunevetmab" title="Frunevetmab">Frunevetmab</a></li> <li><a href="/wiki/Fulranumab" title="Fulranumab">Fulranumab</a></li> <li><a href="/w/index.php?title=MEDI-578&action=edit&redlink=1" class="new" title="MEDI-578 (page does not exist)">MEDI-578</a></li> <li><a href="/w/index.php?title=Ranevetmab&action=edit&redlink=1" class="new" title="Ranevetmab (page does not exist)">Ranevetmab</a></li> <li><a href="/wiki/Tanezumab" title="Tanezumab">Tanezumab</a></li></ul> <ul><li><i>Aptamers:</i> <i>Against NGF:</i> <a href="/w/index.php?title=RBM-004&action=edit&redlink=1" class="new" title="RBM-004 (page does not exist)">RBM-004</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/w/index.php?title=ReN-1820&action=edit&redlink=1" class="new" title="ReN-1820 (page does not exist)">ReN-1820 (TrkAd5)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TrkB_receptor" class="mw-redirect" title="TrkB receptor">TrkB</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=3,7-Dihydroxyflavone&action=edit&redlink=1" class="new" title="3,7-Dihydroxyflavone (page does not exist)">3,7-DHF</a></li> <li><a href="/w/index.php?title=3,7,8,2%27-Tetrahydroxyflavone&action=edit&redlink=1" class="new" title="3,7,8,2'-Tetrahydroxyflavone (page does not exist)">3,7,8,2'-THF</a></li> <li><a href="/wiki/4%27-Dimethylamino-7,8-dihydroxyflavone" class="mw-redirect" title="4'-Dimethylamino-7,8-dihydroxyflavone">4'-DMA-7,8-DHF</a></li> <li><a href="/w/index.php?title=7,3%E2%80%B2-Dihydroxyflavone&action=edit&redlink=1" class="new" title="7,3′-Dihydroxyflavone (page does not exist)">7,3'-DHF</a></li> <li><a href="/wiki/7,8-Dihydroxyflavone" class="mw-redirect" title="7,8-Dihydroxyflavone">7,8-DHF</a></li> <li><a href="/w/index.php?title=7,8,2%27-Trihydroxyflavone&action=edit&redlink=1" class="new" title="7,8,2'-Trihydroxyflavone (page does not exist)">7,8,2'-THF</a></li> <li><a href="/wiki/7,8,3%27-Trihydroxyflavone" title="7,8,3'-Trihydroxyflavone">7,8,3'-THF</a></li> <li><a href="/wiki/Amitriptyline" title="Amitriptyline">Amitriptyline</a></li> <li><a href="/wiki/Brain-derived_neurotrophic_factor" title="Brain-derived neurotrophic factor">BDNF</a></li> <li><a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/Deoxygedunin" title="Deoxygedunin">Deoxygedunin</a></li> <li><a href="/wiki/Deprenyl" title="Deprenyl">Deprenyl</a></li> <li><a href="/wiki/Diosmetin" title="Diosmetin">Diosmetin</a></li> <li><a href="/w/index.php?title=DMAQ-B1&action=edit&redlink=1" class="new" title="DMAQ-B1 (page does not exist)">DMAQ-B1</a></li> <li><a href="/wiki/HIOC" title="HIOC">HIOC</a></li> <li><a href="/wiki/LM22A-4" title="LM22A-4">LM22A-4</a></li> <li><a href="/wiki/N-Acetylserotonin" title="N-Acetylserotonin">N-Acetylserotonin</a></li> <li><a href="/wiki/Neurotrophin-3" title="Neurotrophin-3">NT-3</a></li> <li><a href="/wiki/Neurotrophin-4" title="Neurotrophin-4">NT-4</a></li> <li><a href="/wiki/Norwogonin" title="Norwogonin">Norwogonin (5,7,8-THF)</a></li> <li><a href="/wiki/R7_(drug)" title="R7 (drug)">R7</a></li> <li><a href="/wiki/R13_(drug)" title="R13 (drug)">R13</a></li> <li><a href="/w/index.php?title=TDP6&action=edit&redlink=1" class="new" title="TDP6 (page does not exist)">TDP6</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/ANA-12" title="ANA-12">ANA-12</a></li> <li><a href="/wiki/Cyclotraxin_B" title="Cyclotraxin B">Cyclotraxin B</a></li> <li><a href="/wiki/Gossypetin" title="Gossypetin">Gossypetin (3,5,7,8,3',4'-HHF)</a></li></ul> <ul><li><i>Ligands:</i> <a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AZD-6918&action=edit&redlink=1" class="new" title="AZD-6918 (page does not exist)">AZD-6918</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/w/index.php?title=CH-7057288&action=edit&redlink=1" class="new" title="CH-7057288 (page does not exist)">CH-7057288</a></li> <li><a href="/w/index.php?title=DS-6051&action=edit&redlink=1" class="new" title="DS-6051 (page does not exist)">DS-6051</a></li> <li><a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a></li> <li><a href="/w/index.php?title=GZ-389988&action=edit&redlink=1" class="new" title="GZ-389988 (page does not exist)">GZ-389988</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/wiki/Larotrectinib" title="Larotrectinib">Larotrectinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/w/index.php?title=ONO-4474&action=edit&redlink=1" class="new" title="ONO-4474 (page does not exist)">ONO-4474</a></li> <li><a href="/w/index.php?title=ONO-5390556&action=edit&redlink=1" class="new" title="ONO-5390556 (page does not exist)">ONO-5390556</a></li> <li><a href="/w/index.php?title=PLX-7486&action=edit&redlink=1" class="new" title="PLX-7486 (page does not exist)">PLX-7486</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TrkC_receptor" class="mw-redirect" title="TrkC receptor">TrkC</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li> <li><a href="/wiki/Neurotrophin-3" title="Neurotrophin-3">NT-3</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AZD-6918&action=edit&redlink=1" class="new" title="AZD-6918 (page does not exist)">AZD-6918</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/w/index.php?title=CH-7057288&action=edit&redlink=1" class="new" title="CH-7057288 (page does not exist)">CH-7057288</a></li> <li><a href="/w/index.php?title=DS-6051&action=edit&redlink=1" class="new" title="DS-6051 (page does not exist)">DS-6051</a></li> <li><a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a></li> <li><a href="/w/index.php?title=GZ-389988&action=edit&redlink=1" class="new" title="GZ-389988 (page does not exist)">GZ-389988</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/wiki/Larotrectinib" title="Larotrectinib">Larotrectinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/w/index.php?title=ONO-4474&action=edit&redlink=1" class="new" title="ONO-4474 (page does not exist)">ONO-4474</a></li> <li><a href="/w/index.php?title=ONO-5390556&action=edit&redlink=1" class="new" title="ONO-5390556 (page does not exist)">ONO-5390556</a></li> <li><a href="/w/index.php?title=PLX-7486&action=edit&redlink=1" class="new" title="PLX-7486 (page does not exist)">PLX-7486</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Vascular_endothelial_growth_factor_receptor" class="mw-redirect" title="Vascular endothelial growth factor receptor">VEGF</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Placental_growth_factor" title="Placental growth factor">Placental growth factor (PGF)</a></li> <li><a href="/wiki/Ripretinib" title="Ripretinib">Ripretinib</a></li> <li><a href="/w/index.php?title=Telbermin&action=edit&redlink=1" class="new" title="Telbermin (page does not exist)">Telbermin</a></li> <li><a href="/wiki/Vascular_endothelial_growth_factor" title="Vascular endothelial growth factor">VEGF</a> (<a href="/wiki/Vascular_endothelial_growth_factor_A" title="Vascular endothelial growth factor A">A</a>, <a href="/wiki/Vascular_endothelial_growth_factor_B" title="Vascular endothelial growth factor B">B</a>, <a href="/wiki/Vascular_endothelial_growth_factor_C" title="Vascular endothelial growth factor C">C</a>, <a href="/wiki/Vascular_endothelial_growth_factor_D" class="mw-redirect" title="Vascular endothelial growth factor D">D (FIGF)</a>)</li></ul> <ul><li><i>Allosteric modulators:</i> <a href="/wiki/Cyclotraxin_B" title="Cyclotraxin B">Cyclotraxin B</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/wiki/Axitinib" title="Axitinib">Axitinib</a></li> <li><a href="/wiki/Cabozantinib" title="Cabozantinib">Cabozantinib</a></li> <li><a href="/wiki/Cediranib" title="Cediranib">Cediranib</a></li> <li><a href="/wiki/Fruquintinib" title="Fruquintinib">Fruquintinib</a></li> <li><a href="/wiki/Lapatinib" title="Lapatinib">Lapatinib</a></li> <li><a href="/wiki/Lenvatinib" title="Lenvatinib">Lenvatinib</a></li> <li><a href="/wiki/Motesanib" title="Motesanib">Motesanib</a></li> <li><a href="/wiki/Nintedanib" title="Nintedanib">Nintedanib</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Pegaptanib" title="Pegaptanib">Pegaptanib</a></li> <li><a href="/wiki/Rebastinib" class="mw-redirect" title="Rebastinib">Rebastinib</a></li> <li><a href="/wiki/Regorafenib" title="Regorafenib">Regorafenib</a></li> <li><a href="/wiki/Semaxanib" title="Semaxanib">Semaxanib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Toceranib" title="Toceranib">Toceranib</a></li> <li><a href="/wiki/Tivozanib" title="Tivozanib">Tivozanib</a></li> <li><a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li> <li><a href="/w/index.php?title=WHI-P_154&action=edit&redlink=1" class="new" title="WHI-P 154 (page does not exist)">WHI-P 154</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Alacizumab_pegol" title="Alacizumab pegol">Alacizumab pegol</a></li> <li><a href="/wiki/Bevacizumab" title="Bevacizumab">Bevacizumab</a></li> <li><a href="/wiki/Icrucumab" title="Icrucumab">Icrucumab</a></li> <li><a href="/wiki/Ramucirumab" title="Ramucirumab">Ramucirumab</a></li> <li><a href="/wiki/Ranibizumab" title="Ranibizumab">Ranibizumab</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/wiki/Aflibercept" title="Aflibercept">Aflibercept</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Additional growth factors:</i> <a href="/wiki/Adrenomedullin" title="Adrenomedullin">Adrenomedullin</a></li> <li><a href="/wiki/Colony-stimulating_factor" title="Colony-stimulating factor">Colony-stimulating factors</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Connective_tissue_growth_factor" class="mw-redirect" title="Connective tissue growth factor">Connective tissue growth factor (CTGF)</a></li> <li><a href="/wiki/Ephrin" title="Ephrin">Ephrins</a> (<a href="/wiki/EFNA1" class="mw-redirect" title="EFNA1">A1</a>, <a href="/wiki/EFNA2" class="mw-redirect" title="EFNA2">A2</a>, <a href="/wiki/EFNA3" class="mw-redirect" title="EFNA3">A3</a>, <a href="/wiki/EFNA4" class="mw-redirect" title="EFNA4">A4</a>, <a href="/wiki/EFNA5" class="mw-redirect" title="EFNA5">A5</a>, <a href="/wiki/EFNB1" class="mw-redirect" title="EFNB1">B1</a>, <a href="/wiki/EFNB2" class="mw-redirect" title="EFNB2">B2</a>, <a href="/wiki/EFNB3" class="mw-redirect" title="EFNB3">B3</a>)</li> <li><a href="/wiki/Erythropoietin" title="Erythropoietin">Erythropoietin</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Glucose-6-phosphate_isomerase" title="Glucose-6-phosphate isomerase">Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)</a></li> <li><a href="/wiki/Glia_maturation_factor" title="Glia maturation factor">Glia maturation factor (GMF)</a></li> <li><a href="/wiki/Hepatoma-derived_growth_factor" title="Hepatoma-derived growth factor">Hepatoma-derived growth factor (HDGF)</a></li> <li><a href="/wiki/Interleukin" title="Interleukin">Interleukins</a>/<a href="/wiki/T-cell_growth_factor" title="T-cell growth factor">T-cell growth factors</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Leukemia_inhibitory_factor" title="Leukemia inhibitory factor">Leukemia inhibitory factor (LIF)</a></li> <li><a href="/wiki/Macrophage-stimulating_protein" class="mw-redirect" title="Macrophage-stimulating protein">Macrophage-stimulating protein (MSP; HLP, HGFLP)</a></li> <li><a href="/wiki/Midkine" title="Midkine">Midkine (NEGF2)</a></li> <li><a href="/wiki/Migration-stimulating_factor" class="mw-redirect" title="Migration-stimulating factor">Migration-stimulating factor (MSF; PRG4)</a></li> <li><a href="/wiki/Oncomodulin" title="Oncomodulin">Oncomodulin</a></li> <li><a href="/wiki/Pituitary_adenylate_cyclase-activating_peptide" title="Pituitary adenylate cyclase-activating peptide">Pituitary adenylate cyclase-activating peptide (PACAP)</a></li> <li><a href="/wiki/Pleiotrophin" title="Pleiotrophin">Pleiotrophin</a></li> <li><a href="/wiki/Renalase" title="Renalase">Renalase</a></li> <li><a href="/wiki/Thrombopoietin" title="Thrombopoietin">Thrombopoietin</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Wnt_signaling_pathway" title="Wnt signaling pathway">Wnt signaling proteins</a></li></ul> <ul><li><i>Additional growth factor receptor modulators:</i> <a href="/wiki/Cerebrolysin" title="Cerebrolysin">Cerebrolysin</a> (neurotrophin mixture)</li></ul> </div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output .portal-bar-bordered{padding:0 2em;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em auto 0}.mw-parser-output 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