Australian Prescriber - Therapeutic Guidelines

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<div class="inner"> <div class="wrap"> <div class="text"> <h2 class="color-dark-violet">SUBSCRIBE TO AUSTRALIAN PRESCRIBER</h2> <span class="line medium bg-vivid-red"></span> <div class="des"> <p> Free subscriptions for <i>Australian Prescriber</i> are available through Therapeutic Guidelines. </p> </div> <a href="/subscribe" class="link dark-violet" aria-label="Subscribe to Australian Prescriber"> <span class="txt">Subscribe now</span> <span class="icon-icn-arrow"></span> </a> </div> </div> </div> </section> <div class="box box-wrap"> <div class="box box-feature"> <div class="title level-2 strong-pink is-link"> <ul class="ul-title"> <li> <h2 class="h5 tgissueheading">Volume 48 Issue 1</h2> </li> <li> <span class="post-date tgissuepubdate">February 2025</span> </li> </ul> <ul class="ul-link"> <li> <a href="/assets/AP/pdf/February-48-1-32pp.pdf" target="_blank" class="share strong-pink tgissuepdflink" aria-label="Download latest issue PDF"> <span class="icon-icn-download-new"></span> 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tgissuefirstitemheading"><em>Australian Prescriber:</em> celebrating 50 years of growth and change</a></h2> </div>   <div class="list two-col fd-row normal"> <div class="item"> <a class="block tgissuefirstitemlink" href="/articles/physical-health-monitoring-for-people-with-schizophrenia.html"> <div class="img"> <img class="lazy tgissuefirstitemimg" src="/assets/AP/images/_700x468_crop_center-center_75_none/50-years.png" data-src="/assets/AP/images/_700x468_crop_center-center_75_none/50-years.png" alt="Australian Prescriber: celebrating 50 years of growth and change"> </div> </a> </div> <div class="item"> <div class="text"> <span class="sub-heading color-strong-pink tgissuefirstitemtype">Editorial</span> <div class="post"> <span class="txt tgissuefirstitemauthor">Rosie Scott</span> <ul class="ul-text small dark-gray"> <li class="tgissuefirstitempubdate">18 February 2025</li> </ul> </div> <div class="des"> <a class="block tgissuefirstitemintrotextlink" href="/articles/Australian-Prescriber-celebrating-50-years-of-growth-and-change.html"> <p class="tgissuefirstitemintrotext">This year marks a momentous milestone in the history of <em>Australian Prescriber</em>, as we celebrate its 50-year anniversary. This Editorial looks at the growth and change over this period that have led to <em>Australian Prescriber</em> achieving its purpose of helping health professionals make informed choices when prescribing.</p> </a> </div> </div> </div> </div>  </div> </div>  <div class="box box-wrap small w-border"> <div class="topic-list tgissueitems"> <div class="topic-item"> <div class="box box-feature"> <div class="text on-mobile"> <span class="sub-heading color-strong-pink">Article</span> <h3 class="h4"><a href="/articles/drug-safety-in-pregnancy.html">Drug safety in pregnancy</a></h3> </div> <div class="list two-col fd-row medium"> <div class="item"> <a href="/articles/drug-safety-in-pregnancy.html" class="block"> <div class="img"> <img class="lazy" src="/assets/AP/images/_700x468_crop_center-center_75_none/Drug-safety-in-pregnancy.png" data-src="/assets/AP/images/_700x468_crop_center-center_75_none/Drug-safety-in-pregnancy.png" alt="Drug safety in pregnancy thumbnail"> </div> </a> </div> <div class="item"> <div class="text"> <span class="sub-heading color-strong-pink on-ipad">Article</span> <h3 class="h4 on-ipad"><a href="/articles/drug-safety-in-pregnancy.html">Drug safety in pregnancy</a></h3> <div class="post"> <span class="txt">Debra Kennedy, Ronald Batagol</span> <ul class="ul-text small dark-gray"> <li>18 February 2025</li> </ul> </div> <div class="des"> <a class="block" href="/articles/drug-safety-in-pregnancy.html"> <p>This article discusses how drugs affect the fetus, the challenges in obtaining drug safety data in pregnancy, and limitations of the Australian categorisation system. It highlights the importance of weighing the benefits and risks of drug treatment during pregnancy and provides resources for healthcare professionals and consumers.</p> </a> </div> </div> </div> </div> </div> </div><div class="topic-item"> <div class="box box-feature"> <div class="text on-mobile"> <span class="sub-heading color-strong-pink">Article</span> <h3 class="h4"><a href="/articles/device-assisted-therapies-for-Parkinson-disease.html">Device-assisted therapies for Parkinson disease</a></h3> </div> <div class="list two-col fd-row medium"> <div class="item"> <a href="/articles/device-assisted-therapies-for-Parkinson-disease.html" class="block"> <div class="img"> <img class="lazy" src="/assets/AP/images/_700x468_crop_center-center_75_none/Device-assisted-therapies-for-Parkinson-disease.png" data-src="/assets/AP/images/_700x468_crop_center-center_75_none/Device-assisted-therapies-for-Parkinson-disease.png" alt="Device-assisted therapies for Parkinson disease thumbnail"> </div> </a> </div> <div class="item"> <div class="text"> <span class="sub-heading color-strong-pink on-ipad">Article</span> <h3 class="h4 on-ipad"><a href="/articles/device-assisted-therapies-for-Parkinson-disease.html">Device-assisted therapies for Parkinson disease</a></h3> <div class="post"> <span class="txt">Nadia Mouchaileh, Jillian Cameron</span> <ul class="ul-text small dark-gray"> <li>18 February 2025</li> </ul> </div> <div class="des"> <a class="block" href="/articles/device-assisted-therapies-for-Parkinson-disease.html"> <p>When motor fluctuations and dyskinesias are severe and persistent despite optimised oral and transdermal therapy, device-assisted therapies (drugs delivered by continuous intestinal or subcutaneous infusion, or deep brain stimulation) may be helpful.</p> </a> </div> </div> </div> </div> </div> </div><div class="topic-item"> <div class="box box-feature"> <div class="text on-mobile"> <span class="sub-heading color-strong-pink">Article</span> <h3 class="h4"><a href="/articles/the-role-of-triple-antithrombotic-therapy-in-patients-with-atrial-fibrillation-and-coronary-stent-insertion.html">The role of triple antithrombotic therapy in patients with atrial fibrillation and coronary stent insertion</a></h3> </div> <div class="list two-col fd-row medium"> <div class="item"> <a href="/articles/the-role-of-triple-antithrombotic-therapy-in-patients-with-atrial-fibrillation-and-coronary-stent-insertion.html" class="block"> <div class="img"> <img class="lazy" src="/assets/AP/images/_700x468_crop_center-center_75_none/Triple-antithrombotic-therapy-in-patients-with-atrial-fibrillation-and-coronary-stents-insertion.png" data-src="/assets/AP/images/_700x468_crop_center-center_75_none/Triple-antithrombotic-therapy-in-patients-with-atrial-fibrillation-and-coronary-stents-insertion.png" alt="The role of triple antithrombotic therapy in patients with atrial fibrillation and coronary stent insertion thumbnail"> </div> </a> </div> <div class="item"> <div class="text"> <span class="sub-heading color-strong-pink on-ipad">Article</span> <h3 class="h4 on-ipad"><a href="/articles/the-role-of-triple-antithrombotic-therapy-in-patients-with-atrial-fibrillation-and-coronary-stent-insertion.html">The role of triple antithrombotic therapy in patients with atrial fibrillation and coronary stent insertion</a></h3> <div class="post"> <span class="txt">Kate Ziser, Saqib Rahman, Reham Soro, Nazanin Falconer, Danielle Harrop</span> <ul class="ul-text small dark-gray"> <li>18 February 2025</li> </ul> </div> <div class="des"> <a class="block" href="/articles/the-role-of-triple-antithrombotic-therapy-in-patients-with-atrial-fibrillation-and-coronary-stent-insertion.html"> <p>Triple antithrombotic therapy is most commonly indicated for patients who require long-term anticoagulation for atrial fibrillation plus dual antiplatelet therapy following coronary stent insertion for acute coronary syndrome. Recent guidelines advocate up to 1 week of triple therapy for most patients, extending up to 1 month for those at high ischaemic risk, to balance bleeding and ischaemic risks.</p> </a> </div> </div> </div> </div> </div> </div><div class="topic-item"> <div class="box box-feature"> <div class="text on-mobile"> <span class="sub-heading color-strong-pink">Medicinal mishap</span> <h3 class="h4"><a href="/articles/propranolol-overdose-following-prescription-for-anxiety.html">Propranolol overdose following prescription for anxiety</a></h3> </div> <div class="list two-col fd-row medium"> <div class="item"> <a href="/articles/propranolol-overdose-following-prescription-for-anxiety.html" class="block"> <div class="img"> <img class="lazy" src="/assets/AP/images/_700x468_crop_center-center_75_none/Propranolol-overdose-following-prescription-for-anxiety.png" data-src="/assets/AP/images/_700x468_crop_center-center_75_none/Propranolol-overdose-following-prescription-for-anxiety.png" alt="Propranolol overdose following prescription for anxiety thumbnail"> </div> </a> </div> <div class="item"> <div class="text"> <span class="sub-heading color-strong-pink on-ipad">Medicinal mishap</span> <h3 class="h4 on-ipad"><a href="/articles/propranolol-overdose-following-prescription-for-anxiety.html">Propranolol overdose following prescription for anxiety</a></h3> <div class="post"> <span class="txt">Evan Browne, Jacqueline Huber, Bridin Murnion</span> <ul class="ul-text small dark-gray"> <li>18 February 2025</li> </ul> </div> <div class="des"> <a class="block" href="/articles/propranolol-overdose-following-prescription-for-anxiety.html"> <p>There is insufficient evidence to support routine use of propranolol or other beta blockers in managing symptoms of anxiety, and they should be used with extreme caution in patients with a history of overdose.</p> </a> </div> </div> </div> </div> </div> </div><div class="topic-item"> <div class="box box-feature"> <div class="text on-mobile"> <span class="sub-heading color-strong-pink">Editorial</span> <h3 class="h4"><a href="/articles/new-drug-comments-aiming-to-deliver-useful-timely-independent-information-for-health-professionals.html">New drug comments: aiming to deliver useful, timely, independent information for health professionals</a></h3> </div> <div class="list two-col fd-row medium"> <div class="item"> <a href="/articles/new-drug-comments-aiming-to-deliver-useful-timely-independent-information-for-health-professionals.html" class="block"> <div class="img"> <img class="lazy" src="/assets/AP/images/_700x468_crop_center-center_75_none/New-drug-comments.png" data-src="/assets/AP/images/_700x468_crop_center-center_75_none/New-drug-comments.png" alt="New drug comments: aiming to deliver useful, timely, independent information for health professionals thumbnail"> </div> </a> </div> <div class="item"> <div class="text"> <span class="sub-heading color-strong-pink on-ipad">Editorial</span> <h3 class="h4 on-ipad"><a href="/articles/new-drug-comments-aiming-to-deliver-useful-timely-independent-information-for-health-professionals.html">New drug comments: aiming to deliver useful, timely, independent information for health professionals</a></h3> <div class="post"> <span class="txt">Tilenka Thynne, Rohan Elliott</span> <ul class="ul-text small dark-gray"> <li>18 February 2025</li> </ul> </div> <div class="des"> <a class="block" href="/articles/new-drug-comments-aiming-to-deliver-useful-timely-independent-information-for-health-professionals.html"> <p>Since 1975, the 'New drugs' section of <em>Australian Prescriber</em> has provided succinct, independent comments about recently marketed medicines. To enhance usability, we have changed the format. Read about the changes, and how ‘New drug comments’ can be used in this editorial.</p> </a> </div> </div> </div> </div> </div> </div><div class="topic-item"> <div class="title level-2 strong-pink"> <h2 class="h5 text-uppercase">New drugs</h2> </div><br><div class="box box-feature"> <div class="text on-mobile"> <span class="sub-heading color-strong-pink">New drug</span> <h3 class="h4"><a href="/articles/etrasimod-for-moderate-to-severe-ulcerative-colitis.html">Etrasimod for moderate to severe ulcerative colitis</a></h3> </div> <div class="list two-col fd-row medium"> <div class="item"> <a href="/articles/etrasimod-for-moderate-to-severe-ulcerative-colitis.html" class="block"> <div class="img"> <img class="lazy" src="/assets/AP/images/_700x468_crop_center-center_75_none/Etrasimod-for-moderate-to-severe-ulcerative-colitis.png" data-src="/assets/AP/images/_700x468_crop_center-center_75_none/Etrasimod-for-moderate-to-severe-ulcerative-colitis.png" alt="Etrasimod for moderate to severe ulcerative colitis thumbnail"> </div> </a> </div> <div class="item"> <div class="text"> <span class="sub-heading color-strong-pink on-ipad">New drug</span> <h3 class="h4 on-ipad"><a href="/articles/etrasimod-for-moderate-to-severe-ulcerative-colitis.html">Etrasimod for moderate to severe ulcerative colitis</a></h3> <div class="post"> <ul class="ul-text small dark-gray"> <li>18 February 2025</li> </ul> </div> <div class="des"> <a class="block" href="/articles/etrasimod-for-moderate-to-severe-ulcerative-colitis.html"> <p>Etrasimod has an overall advantage over placebo for patients with ulcerative colitis, but few patients will have a prolonged response.</p> </a> </div> </div> </div> </div> </div> </div><div class="topic-item"> <div class="box box-feature"> <div class="text on-mobile"> <span class="sub-heading color-strong-pink">New drug</span> <h3 class="h4"><a href="/articles/mavacamten-for-symptomatic-obstructive-hypertrophic-cardiomyopathy.html">Mavacamten for symptomatic obstructive hypertrophic cardiomyopathy</a></h3> </div> <div class="list two-col fd-row medium"> <div class="item"> <a href="/articles/mavacamten-for-symptomatic-obstructive-hypertrophic-cardiomyopathy.html" class="block"> <div class="img"> <img class="lazy" src="/assets/AP/images/_700x468_crop_center-center_75_none/Mavacamten-for-symptomatic-obstructive-hypertrophic-cardiomyopathy.png" data-src="/assets/AP/images/_700x468_crop_center-center_75_none/Mavacamten-for-symptomatic-obstructive-hypertrophic-cardiomyopathy.png" alt="Mavacamten for symptomatic obstructive hypertrophic cardiomyopathy thumbnail"> </div> </a> </div> <div class="item"> <div class="text"> <span class="sub-heading color-strong-pink on-ipad">New drug</span> <h3 class="h4 on-ipad"><a href="/articles/mavacamten-for-symptomatic-obstructive-hypertrophic-cardiomyopathy.html">Mavacamten for symptomatic obstructive hypertrophic cardiomyopathy</a></h3> <div class="post"> <ul class="ul-text small dark-gray"> <li>18 February 2025</li> </ul> </div> <div class="des"> <a class="block" href="/articles/mavacamten-for-symptomatic-obstructive-hypertrophic-cardiomyopathy.html"> <p>Mavacamten, a first-in-class treatment, may be capable of achieving a sustained, marked relief in symptoms of obstructive hypertrophic cardiomyopathy; however, close echocardiographic monitoring is important to reduce the risk of heart failure.</p> </a> </div> </div> </div> </div> </div> </div><div class="topic-item"> <div class="box box-feature"> <div class="text on-mobile"> <span class="sub-heading color-strong-pink">New drug</span> <h3 class="h4"><a href="/articles/teclistamab-for-relapsed-or-refractory-multiple-myeloma.html">Teclistamab for relapsed or refractory multiple myeloma</a></h3> </div> <div class="list two-col fd-row medium"> <div class="item"> <a href="/articles/teclistamab-for-relapsed-or-refractory-multiple-myeloma.html" class="block"> <div class="img"> <img class="lazy" src="/assets/AP/images/_700x468_crop_center-center_75_none/Teclistamab-for-relapsed-or-refractory-multiple-myeloma.png" data-src="/assets/AP/images/_700x468_crop_center-center_75_none/Teclistamab-for-relapsed-or-refractory-multiple-myeloma.png" alt="Teclistamab for relapsed or refractory multiple myeloma thumbnail"> </div> </a> </div> <div class="item"> <div class="text"> <span class="sub-heading color-strong-pink on-ipad">New drug</span> <h3 class="h4 on-ipad"><a href="/articles/teclistamab-for-relapsed-or-refractory-multiple-myeloma.html">Teclistamab for relapsed or refractory multiple myeloma</a></h3> <div class="post"> <ul class="ul-text small dark-gray"> <li>18 February 2025</li> </ul> </div> <div class="des"> <a class="block" href="/articles/teclistamab-for-relapsed-or-refractory-multiple-myeloma.html"> <p>Teclistamab is a new subcutaneous injection for relapsed or refractory multiple myeloma, with provisional approval in Australia. Initial step-up dosing with pretreatment medications is required to manage the risk of adverse effects such as cytokine release syndrome.</p> </a> </div> </div> </div> </div> </div> </div><div class="topic-item"> <div class="title level-2 strong-pink"> <h2 class="h5 text-uppercase">TGA Medicines Safety Update summary</h2> </div><br><div class="box box-feature"> <div class="text on-mobile"> <span class="sub-heading color-strong-pink">TGA Medicines Safety Update summary</span> <h3 class="h4"><a href="/articles/promethazine-hydrochloride-phenergan-not-to-be-used-in-children-under-6.html">Promethazine hydrochloride (Phenergan) not to be used in children under 6</a></h3> </div> <div class="list two-col fd-row medium"> <div class="item"> <a href="/articles/promethazine-hydrochloride-phenergan-not-to-be-used-in-children-under-6.html" class="block"> <div class="img"> <img class="lazy" src="/assets/AP/images/_700x468_crop_center-center_75_none/TGA-Med-safety-update-summary.jpg" data-src="/assets/AP/images/_700x468_crop_center-center_75_none/TGA-Med-safety-update-summary.jpg" alt="Promethazine hydrochloride (Phenergan) not to be used in children under 6 thumbnail"> </div> </a> </div> <div class="item"> <div class="text"> <span class="sub-heading color-strong-pink on-ipad">TGA Medicines Safety Update summary</span> <h3 class="h4 on-ipad"><a href="/articles/promethazine-hydrochloride-phenergan-not-to-be-used-in-children-under-6.html">Promethazine hydrochloride (Phenergan) not to be used in children under 6</a></h3> <div class="post"> <ul class="ul-text small dark-gray"> <li>18 February 2025</li> </ul> </div> <div class="des"> <a class="block" href="/articles/promethazine-hydrochloride-phenergan-not-to-be-used-in-children-under-6.html"> </a> </div> </div> </div> </div> </div> </div><div class="topic-item"> <div class="box box-feature"> <div class="text on-mobile"> <span class="sub-heading color-strong-pink">TGA Medicines Safety Update summary</span> <h3 class="h4"><a href="/articles/more-prominent-safety-warnings-about-the-neuropsychiatric-effects-of-montelukast.html">More prominent safety warnings about the neuropsychiatric effects of montelukast</a></h3> </div> <div class="list two-col fd-row medium"> <div class="item"> <a href="/articles/more-prominent-safety-warnings-about-the-neuropsychiatric-effects-of-montelukast.html" class="block"> <div class="img"> <img class="lazy" src="/assets/AP/images/_700x468_crop_center-center_75_none/TGA-Med-safety-update-summary.jpg" data-src="/assets/AP/images/_700x468_crop_center-center_75_none/TGA-Med-safety-update-summary.jpg" alt="More prominent safety warnings about the neuropsychiatric effects of montelukast thumbnail"> </div> </a> </div> <div class="item"> <div class="text"> <span class="sub-heading color-strong-pink on-ipad">TGA Medicines Safety Update summary</span> <h3 class="h4 on-ipad"><a href="/articles/more-prominent-safety-warnings-about-the-neuropsychiatric-effects-of-montelukast.html">More prominent safety warnings about the neuropsychiatric effects of montelukast</a></h3> <div class="post"> <ul class="ul-text small dark-gray"> <li>18 February 2025</li> </ul> </div> <div class="des"> <a class="block" href="/articles/more-prominent-safety-warnings-about-the-neuropsychiatric-effects-of-montelukast.html"> </a> </div> </div> </div> </div> </div> </div></div> </div> </div> <div class="col"> <div class="box box-feature"> <section class="panel panel-ref is-border small on-desktop"> <div class="inner"> <div class="wrap"> <div class="text"> <h2 class="color-dark-violet">SUBSCRIBE TO AUSTRALIAN PRESCRIBER</h2> <span class="line medium bg-vivid-red"></span> <div class="des"> <p> Free subscriptions for <i>Australian Prescriber</i> are available through Therapeutic Guidelines. </p> </div> <a href="/subscribe" class="link dark-violet" aria-label="Subscribe to Australian 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