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Development and Excitability" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/55167089/Kainate_Receptor_Auxiliary_Subunit_NETO2_Related_Cued_Fear_Conditioning_Impairments_Associate_with_Defects_in_Amygdala_Development_and_Excitability">Kainate Receptor Auxiliary Subunit NETO2-Related Cued Fear Conditioning Impairments Associate with Defects in Amygdala Development and Excitability</a></div><div class="wp-workCard_item"><span>eneuro</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper 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wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55167085/Maternal_stress_or_sleep_during_pregnancy_are_not_reflected_on_telomere_length_of_newborns">Maternal stress or sleep during pregnancy are not reflected on telomere length of newborns</a></div><div class="wp-workCard_item"><span>Scientific Reports</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Telomeres play an important role in maintaining chromosomal integrity. With each cell division, t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Telomeres play an important role in maintaining chromosomal integrity. With each cell division, telomeres are shortened and leukocyte telomere length (LTL) has therefore been considered a marker for biological age. LTL is associated with various lifetime stressors and health-related outcomes. Transgenerational effects have been implicated in newborns, with maternal stress, depression, and anxiety predicting shorter telomere length at birth, possibly reflecting the intrauterine growth environment. Previous studies, with relatively small sample sizes, have reported an effect of maternal stress, BMI, and depression during pregnancy on the LTL of newborns. Here, we attempted to replicate previous findings on prenatal stress and newborn LTL in a sample of 1405 infants using a qPCR-based method. In addition, previous research has been expanded by studying the relationship between maternal sleep quality and LTL. Maternal prenatal stress, anxiety, depression, BMI, and self-reported sleep qu...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b9473a90fd4df83c676e00a245fc0411" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71167329,"asset_id":55167085,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71167329/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55167085"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55167085"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55167085; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55167085]").text(description); $(".js-view-count[data-work-id=55167085]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55167085; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55167085']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55167085, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b9473a90fd4df83c676e00a245fc0411" } } $('.js-work-strip[data-work-id=55167085]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55167085,"title":"Maternal stress or sleep during pregnancy are not reflected on telomere length of newborns","translated_title":"","metadata":{"abstract":"Telomeres play an important role in maintaining chromosomal integrity. 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Despite extensive research in animal models and numerous promising treatment trials, there is still no curative treatment for AD. Astrocytes, the most common cell type of the central nervous system, have been shown to play a role in the major AD pathologies, including accumulation of amyloid plaques, neuroinflammation, and oxidative stress. Here, we show that inflammatory stimulation leads to metabolic activation of human astrocytes and reduces amyloid secretion. On the other hand, the activation of oxidative metabolism leads to increased reactive oxygen species production especially in AD astrocytes. While healthy astrocytes increase glutathione (GSH) release to protect the cells, Presenilin-1-mutated AD patient astrocytes do not. Thus, chronic inflammation is likely to induce oxidative damage in AD astrocytes. Activation of NRF2, the major regulator of cellular antioxidant defenses, encoded by the NFE2L2 gene, poses several beneficial effects on AD astrocytes. We report here that the activation of NRF2 pathway reduces amyloid secretion, normalizes cytokine release, and increases GSH secretion in AD astrocytes. NRF2 induction also activates the metabolism of astrocytes and increases the utilization of glycolysis. Taken together, targeting NRF2 in astrocytes could be a potent therapeutic strategy in AD.","publication_name":"Glia","grobid_abstract_attachment_id":71167725},"translated_abstract":null,"internal_url":"https://www.academia.edu/55167080/NF_E2_related_factor_2_activation_boosts_antioxidant_defenses_and_ameliorates_inflammatory_and_amyloid_properties_in_human_Presenilin_1_mutated_Alzheimers_disease_astrocytes","translated_internal_url":"","created_at":"2021-10-03T09:21:49.367-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49916833,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71167725,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167725/thumbnails/1.jpg","file_name":"glia.pdf","download_url":"https://www.academia.edu/attachments/71167725/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"NF_E2_related_factor_2_activation_boosts.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167725/glia-libre.pdf?1633319159=\u0026response-content-disposition=attachment%3B+filename%3DNF_E2_related_factor_2_activation_boosts.pdf\u0026Expires=1733000333\u0026Signature=X14Bnu8IJEui357Dx0n7RlHCLnZbCrEEK4FY2ck0CrcVejYW8zRAZp~WHHDLY7ZmzxGWvf7G--ozeMCb-LpOU9omznLjw3v4uekOUaugXuUMBXOXSd0cY-2gOOs8fi3vhT1vPQTlShmtG-fkZu3jHk0F4jQKcCk15ckoZ900OdO2KZz5YKetEQrBaHT9patT2NiRZmY6VOv9DVdTHsmkBLhnZGr8T9PjpWx69L8IQsvt9TQKEt1RDFuiDJnoRkEEF-hwOL~KC~yPciSEOWdtJ66peg1V6gkO~X6LTn4FeftUqNgQ1zX5XsYntyVKB2vGDp8YWIVzL2qRICx69cAp6w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"NF_E2_related_factor_2_activation_boosts_antioxidant_defenses_and_ameliorates_inflammatory_and_amyloid_properties_in_human_Presenilin_1_mutated_Alzheimers_disease_astrocytes","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":49916833,"first_name":"Iiris","middle_initials":null,"last_name":"Hovatta","page_name":"IirisHovatta","domain_name":"independent","created_at":"2016-06-11T00:36:19.385-07:00","display_name":"Iiris Hovatta","url":"https://independent.academia.edu/IirisHovatta"},"attachments":[{"id":71167725,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167725/thumbnails/1.jpg","file_name":"glia.pdf","download_url":"https://www.academia.edu/attachments/71167725/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"NF_E2_related_factor_2_activation_boosts.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167725/glia-libre.pdf?1633319159=\u0026response-content-disposition=attachment%3B+filename%3DNF_E2_related_factor_2_activation_boosts.pdf\u0026Expires=1733000333\u0026Signature=X14Bnu8IJEui357Dx0n7RlHCLnZbCrEEK4FY2ck0CrcVejYW8zRAZp~WHHDLY7ZmzxGWvf7G--ozeMCb-LpOU9omznLjw3v4uekOUaugXuUMBXOXSd0cY-2gOOs8fi3vhT1vPQTlShmtG-fkZu3jHk0F4jQKcCk15ckoZ900OdO2KZz5YKetEQrBaHT9patT2NiRZmY6VOv9DVdTHsmkBLhnZGr8T9PjpWx69L8IQsvt9TQKEt1RDFuiDJnoRkEEF-hwOL~KC~yPciSEOWdtJ66peg1V6gkO~X6LTn4FeftUqNgQ1zX5XsYntyVKB2vGDp8YWIVzL2qRICx69cAp6w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":579707,"name":"Glia","url":"https://www.academia.edu/Documents/in/Glia"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[{"id":12106883,"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/glia.23741"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55167077"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55167077/Strong_conservation_of_inbred_mouse_strain_microRNA_loci_but_broad_variation_in_brain_microRNAs_due_to_RNA_editing_and_isomiR_expression"><img alt="Research paper thumbnail of Strong conservation of inbred mouse strain microRNA loci but broad variation in brain microRNAs due to RNA editing and isomiR expression" class="work-thumbnail" src="https://attachments.academia-assets.com/71167718/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55167077/Strong_conservation_of_inbred_mouse_strain_microRNA_loci_but_broad_variation_in_brain_microRNAs_due_to_RNA_editing_and_isomiR_expression">Strong conservation of inbred mouse strain microRNA loci but broad variation in brain microRNAs due to RNA editing and isomiR expression</a></div><div class="wp-workCard_item"><span>RNA</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3332b2889b33575e73de4cb6fcf03d3f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71167718,"asset_id":55167077,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71167718/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55167077"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55167077"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55167077; 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Inbred mouse strains and crosses using them are important reference populations for genetic mapping, and as models of human disease. We determined the nature and extent of interstrain miRNA variation by (i) identifying miRNA SNPs in whole-genome sequence data from 36 strains, and (ii) examining miRNA editing and expression in hippocampus (Hpc) and frontal cortex (FCx) of six strains, to facilitate the study of miRNAs in neurobehavioral phenotypes. miRNA loci were strongly conserved among the 36 strains, but even the highly conserved seed region contained 16 SNPs. In contrast, we identified RNA editing in 58.9% of miRNAs, including 11 consistent editing events in the seed region. We confirmed the functional significance of three conserved edits in the miR-379/410 cluster, demonstrating that edited miRNAs gained novel target mRNAs not recognized by the unedited miRNAs. We found significant interstrain differences in miRNA and isomiR expression: Of 779 miRNAs expressed in Hpc and 719 in FCx, 262 were differentially expressed (190 in Hpc, 126 in FCx, 54 in both). We also identified 32 novel miRNA candidates using miRNA prediction tools. Our studies provide the first comprehensive analysis of SNP, isomiR, and RNA editing variation in miRNA loci across inbred mouse strains, and a detailed catalog of expressed miRNAs in Hpc and FCx in six commonly used strains. These findings will facilitate the molecular analysis of neurological and behavioral phenotypes in this model organism.","publication_name":"RNA","grobid_abstract_attachment_id":71167718},"translated_abstract":null,"internal_url":"https://www.academia.edu/55167077/Strong_conservation_of_inbred_mouse_strain_microRNA_loci_but_broad_variation_in_brain_microRNAs_due_to_RNA_editing_and_isomiR_expression","translated_internal_url":"","created_at":"2021-10-03T09:21:49.226-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49916833,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71167718,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167718/thumbnails/1.jpg","file_name":"643.full.pdf","download_url":"https://www.academia.edu/attachments/71167718/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Strong_conservation_of_inbred_mouse_stra.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167718/643.full-libre.pdf?1633319160=\u0026response-content-disposition=attachment%3B+filename%3DStrong_conservation_of_inbred_mouse_stra.pdf\u0026Expires=1733000333\u0026Signature=fXeoWUbSd3MFN~q6qyPoPH9B9ZmIa2aVDgvpHBLgOgwLIrFzO0GmvJDFnRkdNizNNOKoOYGw2mPiujnNjAppfkvN24AWh1676i~TQNxLKOHCih49yYde7uO5zAunm5vI7KJZRI1GmIZIDaIOprte63Wl4jx4aplofnQE40xw0qAgFXcbLgPflPVHe6TSojadaSaRakPVm7SbiEC7EelqlAYYXtdbEK4huqQ3uQvd9aB5vXLYTqCuoDF6SVl7NqIsuQe8ezq0MduyPM4f7niP3TAyVzpdgrQXgztsyCrNPe0dByOKn108nJnEgDjO-S79pJXKjfkqrKxNEwBD0A0DOg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Strong_conservation_of_inbred_mouse_strain_microRNA_loci_but_broad_variation_in_brain_microRNAs_due_to_RNA_editing_and_isomiR_expression","translated_slug":"","page_count":14,"language":"en","content_type":"Work","owner":{"id":49916833,"first_name":"Iiris","middle_initials":null,"last_name":"Hovatta","page_name":"IirisHovatta","domain_name":"independent","created_at":"2016-06-11T00:36:19.385-07:00","display_name":"Iiris Hovatta","url":"https://independent.academia.edu/IirisHovatta"},"attachments":[{"id":71167718,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167718/thumbnails/1.jpg","file_name":"643.full.pdf","download_url":"https://www.academia.edu/attachments/71167718/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Strong_conservation_of_inbred_mouse_stra.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167718/643.full-libre.pdf?1633319160=\u0026response-content-disposition=attachment%3B+filename%3DStrong_conservation_of_inbred_mouse_stra.pdf\u0026Expires=1733000333\u0026Signature=fXeoWUbSd3MFN~q6qyPoPH9B9ZmIa2aVDgvpHBLgOgwLIrFzO0GmvJDFnRkdNizNNOKoOYGw2mPiujnNjAppfkvN24AWh1676i~TQNxLKOHCih49yYde7uO5zAunm5vI7KJZRI1GmIZIDaIOprte63Wl4jx4aplofnQE40xw0qAgFXcbLgPflPVHe6TSojadaSaRakPVm7SbiEC7EelqlAYYXtdbEK4huqQ3uQvd9aB5vXLYTqCuoDF6SVl7NqIsuQe8ezq0MduyPM4f7niP3TAyVzpdgrQXgztsyCrNPe0dByOKn108nJnEgDjO-S79pJXKjfkqrKxNEwBD0A0DOg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":3701,"name":"RNA","url":"https://www.academia.edu/Documents/in/RNA"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"}],"urls":[{"id":12106881,"url":"https://syndication.highwire.org/content/doi/10.1261/rna.064881.117"}]}, dispatcherData: dispatcherData }); 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In order to identify the potential functional mutations alluded to by these previous findings, we sequenced the 1.5Mb of the PDE4D genomic locus in 20 families (consisting of 96 individuals, and 79 independent chromosomes), followed by two stages of genotyping across 6,668 individuals from multiple Finnish cohorts for major mental illnesses. We identified 4,570 SNPs across the PDE4D gene, with 380 associated to schizophrenia (p≤0.05). Importantly, two of these variants, rs35278 and rs165940, are located at transcription factor binding sites, and displayed replicable association in the two-stage enlargement of the familial schizophrenia cohort, (combined statistics for rs35278 p=0.0012; OR=1.18, 95% CI 1.06-1.32; and rs165940 p=0.0016; OR=1.27, 95% CI 1.13-1.41). Further analysis using additional cohorts and endophenotypes revealed that rs165940 principally associates within the psychosis (p=0.025, OR=1.18, 95% CI 1.07-1.30) and cognitive domains of major mental illnesses (g-score p=0.044, beta=-0.033). Specifically, the cognitive domains represented verbal learning and memory (p=0.0091, beta=-0.044) and verbal working memory (p=0.0062, beta=-0.036). Moreover, expression data from the GTEx database demonstrated that rs165940 significantly correlates with the mRNA expression levels of PDE4D in the cerebellum (p-value=0.04; m-value=0.9), demonstrating a potential functional consequence for this variant. Thus, rs165940 represents the most likely functional variant for major mental illness at the PDE4D locus in the Finnish population, increasing risk broadly to psychotic disorders.","publication_name":"Molecular Psychiatry","grobid_abstract_attachment_id":71167715},"translated_abstract":null,"internal_url":"https://www.academia.edu/55167072/Variants_in_regulatory_elements_of_PDE4D_associate_with_major_mental_illness_in_the_Finnish_population","translated_internal_url":"","created_at":"2021-10-03T09:21:49.091-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49916833,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71167715,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167715/thumbnails/1.jpg","file_name":"390518.full.pdf","download_url":"https://www.academia.edu/attachments/71167715/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Variants_in_regulatory_elements_of_PDE4D.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167715/390518.full-libre.pdf?1633319156=\u0026response-content-disposition=attachment%3B+filename%3DVariants_in_regulatory_elements_of_PDE4D.pdf\u0026Expires=1733000333\u0026Signature=cHd3wIAvL-4tUsiDPfyUqgtgkL1rB~DTZ90wHI4afEprOSSN0uyb3lCtAqzRq1Sx~lB6NOQ9oRRLNwPsHhueNI4caLP7np-cQuoBqMaxQgI3fI-xx76UiiQjdkWdxY9F5nlDdGkT4u7nMbHKVBK~iOMBRAwttN9HjF7BQla65OzE6XR2kF3rEOyUQbSJYRbmuxcEms~xCvsbRbWvyIzDAVktjzgQ78N7aNi2p1dLjmvtqEZa~Hd2P0jMWg1uAji70XqvyFhb4gjordN~-RI8awnGVRcZr9onPMS~IE9XWG-rkt5nkZ8gJzLuFp8LGSTRaxtatpmrnCWZ2HjlZm0dLg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Variants_in_regulatory_elements_of_PDE4D_associate_with_major_mental_illness_in_the_Finnish_population","translated_slug":"","page_count":28,"language":"en","content_type":"Work","owner":{"id":49916833,"first_name":"Iiris","middle_initials":null,"last_name":"Hovatta","page_name":"IirisHovatta","domain_name":"independent","created_at":"2016-06-11T00:36:19.385-07:00","display_name":"Iiris Hovatta","url":"https://independent.academia.edu/IirisHovatta"},"attachments":[{"id":71167715,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167715/thumbnails/1.jpg","file_name":"390518.full.pdf","download_url":"https://www.academia.edu/attachments/71167715/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Variants_in_regulatory_elements_of_PDE4D.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167715/390518.full-libre.pdf?1633319156=\u0026response-content-disposition=attachment%3B+filename%3DVariants_in_regulatory_elements_of_PDE4D.pdf\u0026Expires=1733000333\u0026Signature=cHd3wIAvL-4tUsiDPfyUqgtgkL1rB~DTZ90wHI4afEprOSSN0uyb3lCtAqzRq1Sx~lB6NOQ9oRRLNwPsHhueNI4caLP7np-cQuoBqMaxQgI3fI-xx76UiiQjdkWdxY9F5nlDdGkT4u7nMbHKVBK~iOMBRAwttN9HjF7BQla65OzE6XR2kF3rEOyUQbSJYRbmuxcEms~xCvsbRbWvyIzDAVktjzgQ78N7aNi2p1dLjmvtqEZa~Hd2P0jMWg1uAji70XqvyFhb4gjordN~-RI8awnGVRcZr9onPMS~IE9XWG-rkt5nkZ8gJzLuFp8LGSTRaxtatpmrnCWZ2HjlZm0dLg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":32358,"name":"Molecular Psychiatry","url":"https://www.academia.edu/Documents/in/Molecular_Psychiatry"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":12106880,"url":"http://www.nature.com/articles/s41380-019-0429-x.pdf"}]}, dispatcherData: dispatcherData }); 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Correlations Between Insulin Resistance and Peripheral Immunity in First-Episode Psychosis – a Gene Expression Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/55167064/O10_1_Correlations_Between_Insulin_Resistance_and_Peripheral_Immunity_in_First_Episode_Psychosis_a_Gene_Expression_Study">O10.1. Correlations Between Insulin Resistance and Peripheral Immunity in First-Episode Psychosis – a Gene Expression Study</a></div><div class="wp-workCard_item"><span>Schizophrenia Bulletin</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55167064"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55167064"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55167064; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55167064]").text(description); $(".js-view-count[data-work-id=55167064]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55167064; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55167064']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55167064, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=55167064]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55167064,"title":"O10.1. Correlations Between Insulin Resistance and Peripheral Immunity in First-Episode Psychosis – a Gene Expression Study","translated_title":"","metadata":{"publisher":"Oxford University Press (OUP)","publication_name":"Schizophrenia Bulletin"},"translated_abstract":null,"internal_url":"https://www.academia.edu/55167064/O10_1_Correlations_Between_Insulin_Resistance_and_Peripheral_Immunity_in_First_Episode_Psychosis_a_Gene_Expression_Study","translated_internal_url":"","created_at":"2021-10-03T09:21:48.748-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49916833,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"O10_1_Correlations_Between_Insulin_Resistance_and_Peripheral_Immunity_in_First_Episode_Psychosis_a_Gene_Expression_Study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":49916833,"first_name":"Iiris","middle_initials":null,"last_name":"Hovatta","page_name":"IirisHovatta","domain_name":"independent","created_at":"2016-06-11T00:36:19.385-07:00","display_name":"Iiris Hovatta","url":"https://independent.academia.edu/IirisHovatta"},"attachments":[],"research_interests":[{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":12106878,"url":"http://academic.oup.com/schizophreniabulletin/article-pdf/45/Supplement_2/S190/28306579/sbz021.249.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55167060"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55167060/Genome_wide_Association_Study_of_Anxiety_and_Stress_related_Disorders_in_the_iPSYCH_Cohort"><img alt="Research paper thumbnail of Genome-wide Association Study of Anxiety and Stress-related Disorders in the iPSYCH Cohort" class="work-thumbnail" src="https://attachments.academia-assets.com/71167712/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55167060/Genome_wide_Association_Study_of_Anxiety_and_Stress_related_Disorders_in_the_iPSYCH_Cohort">Genome-wide Association Study of Anxiety and Stress-related Disorders in the iPSYCH Cohort</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Anxiety and stress-related disorders (ASRD) are among the most common mental disorders with the m...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Anxiety and stress-related disorders (ASRD) are among the most common mental disorders with the majority of patients suffering from additional disorders. Family and twin studies indicate that genetic and environmental factors are underlying their etiology. As ASRD are likely to configure various expressions of abnormalities in the basic stress-response system, we conducted a genome-wide association study including 12,655 cases with various anxiety and stress-related diagnoses and 19,225 controls. Standard association analyses were performed supplemented by a framework of sensitivity analyses. Variants in PDE4B showed consistent association with ASRD across a wide range of our analyses. In mice models, alternations in PDE4B expression were observed in those mice displaying anxious behavior after exposure to chronic stress. We also showed that 28% of the variance in ASRD was accounted for by common variants and that the genetic signature of ASRD overlapped with psychiatric traits, edu...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f3d155f693dde3dd8189f3f36b446cf7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71167712,"asset_id":55167060,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71167712/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55167060"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55167060"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55167060; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55167060]").text(description); $(".js-view-count[data-work-id=55167060]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55167060; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55167060']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55167060, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f3d155f693dde3dd8189f3f36b446cf7" } } $('.js-work-strip[data-work-id=55167060]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55167060,"title":"Genome-wide Association Study of Anxiety and Stress-related Disorders in the iPSYCH Cohort","translated_title":"","metadata":{"abstract":"Anxiety and stress-related disorders (ASRD) are among the most common mental disorders with the majority of patients suffering from additional disorders. 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Variants in PDE4B showed consistent association with ASRD across a wide range of our analyses. In mice models, alternations in PDE4B expression were observed in those mice displaying anxious behavior after exposure to chronic stress. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55167055"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/55167055/Gene_environment_interaction_in_myelin_plasticity_after_chronic_psychosocial_stress"><img alt="Research paper thumbnail of Gene-environment interaction in myelin plasticity after chronic psychosocial stress" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/55167055/Gene_environment_interaction_in_myelin_plasticity_after_chronic_psychosocial_stress">Gene-environment interaction in myelin plasticity after chronic psychosocial stress</a></div><div class="wp-workCard_item"><span>European Neuropsychopharmacology</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55167055"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55167055"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55167055; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55167052"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55167052/Genetic_Control_of_Myelin_Plasticity_after_Chronic_Psychosocial_Stress"><img alt="Research paper thumbnail of Genetic Control of Myelin Plasticity after Chronic Psychosocial Stress" class="work-thumbnail" src="https://attachments.academia-assets.com/71167714/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55167052/Genetic_Control_of_Myelin_Plasticity_after_Chronic_Psychosocial_Stress">Genetic Control of Myelin Plasticity after Chronic Psychosocial Stress</a></div><div class="wp-workCard_item"><span>eNeuro</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Anxiety disorders often manifest in genetically susceptible individuals after psychosocial stress...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Anxiety disorders often manifest in genetically susceptible individuals after psychosocial stress, but the mechanisms underlying these gene-environment interactions are largely unknown. We used the chronic social defeat stress (CSDS) mouse model to study resilience and susceptibility to chronic psychosocial stress. We identified a strong genetic background effect in CSDS-induced social avoidance (SA) using four inbred mouse strains: 69% of C57BL/6NCrl (B6), 23% of BALB/cAnNCrl, 19% of 129S2/SvPasCrl, and 5% of DBA/2NCrl (D2) mice were stress resilient. Furthermore, different inbred mouse strains responded differently to stress, suggesting they use distinct coping strategies. To identify biological pathways affected by CSDS, we used RNA-sequencing (RNA-seq) of three brain regions of two strains, B6 and D2: medial prefrontal cortex (mPFC), ventral hippocampus (vHPC), and bed nucleus of the stria terminalis (BNST). We discovered overrepresentation of oligodendrocyte (OLG)-related genes...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1ca3d810d4d63ace3aab4a411d942ac7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71167714,"asset_id":55167052,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71167714/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55167052"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55167052"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55167052; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55167052]").text(description); $(".js-view-count[data-work-id=55167052]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55167052; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55167052']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55167052, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1ca3d810d4d63ace3aab4a411d942ac7" } } $('.js-work-strip[data-work-id=55167052]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55167052,"title":"Genetic Control of Myelin Plasticity after Chronic Psychosocial Stress","translated_title":"","metadata":{"abstract":"Anxiety disorders often manifest in genetically susceptible individuals after psychosocial stress, but the mechanisms underlying these gene-environment interactions are largely unknown. We used the chronic social defeat stress (CSDS) mouse model to study resilience and susceptibility to chronic psychosocial stress. We identified a strong genetic background effect in CSDS-induced social avoidance (SA) using four inbred mouse strains: 69% of C57BL/6NCrl (B6), 23% of BALB/cAnNCrl, 19% of 129S2/SvPasCrl, and 5% of DBA/2NCrl (D2) mice were stress resilient. Furthermore, different inbred mouse strains responded differently to stress, suggesting they use distinct coping strategies. To identify biological pathways affected by CSDS, we used RNA-sequencing (RNA-seq) of three brain regions of two strains, B6 and D2: medial prefrontal cortex (mPFC), ventral hippocampus (vHPC), and bed nucleus of the stria terminalis (BNST). We discovered overrepresentation of oligodendrocyte (OLG)-related genes...","publication_name":"eNeuro"},"translated_abstract":"Anxiety disorders often manifest in genetically susceptible individuals after psychosocial stress, but the mechanisms underlying these gene-environment interactions are largely unknown. We used the chronic social defeat stress (CSDS) mouse model to study resilience and susceptibility to chronic psychosocial stress. We identified a strong genetic background effect in CSDS-induced social avoidance (SA) using four inbred mouse strains: 69% of C57BL/6NCrl (B6), 23% of BALB/cAnNCrl, 19% of 129S2/SvPasCrl, and 5% of DBA/2NCrl (D2) mice were stress resilient. Furthermore, different inbred mouse strains responded differently to stress, suggesting they use distinct coping strategies. To identify biological pathways affected by CSDS, we used RNA-sequencing (RNA-seq) of three brain regions of two strains, B6 and D2: medial prefrontal cortex (mPFC), ventral hippocampus (vHPC), and bed nucleus of the stria terminalis (BNST). We discovered overrepresentation of oligodendrocyte (OLG)-related genes...","internal_url":"https://www.academia.edu/55167052/Genetic_Control_of_Myelin_Plasticity_after_Chronic_Psychosocial_Stress","translated_internal_url":"","created_at":"2021-10-03T09:21:48.338-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49916833,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71167714,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167714/thumbnails/1.jpg","file_name":"ENEURO.0166_18.2018.pdf","download_url":"https://www.academia.edu/attachments/71167714/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Genetic_Control_of_Myelin_Plasticity_aft.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167714/ENEURO.0166_18.2018-libre.pdf?1633319160=\u0026response-content-disposition=attachment%3B+filename%3DGenetic_Control_of_Myelin_Plasticity_aft.pdf\u0026Expires=1733000333\u0026Signature=Nw-GdrtI5VAlBZX0uMn90O8evJOwvm7GzZwpiDI77kSczy7HSNfi6N9wh9Qb-WJzxf5s1BAVSEMooHTJleyGD-R7XzATTY35JBUJ7sUNJJhV9GRKy25fD5qU130J19uDIakuZcfHk9AYJTlBNb1X65Ppq1MDjVtiqhZdX4Ftw5riLNFkUQFvmY5HTAJjfG76pW3f94eiuxAaaEhSWL1Nj5qa4rkqPXAFDyITf1-nGo5G7X8dLPRxjusL4U7VJSqYITpuGSbIIOZaKM3zwkG7nsLjKUUX95IgQ183u99k3qTXMLs3EF5EOEc0dVILKnbTD6PNCVyI2yrDjGjpFuEkIQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Genetic_Control_of_Myelin_Plasticity_after_Chronic_Psychosocial_Stress","translated_slug":"","page_count":16,"language":"en","content_type":"Work","owner":{"id":49916833,"first_name":"Iiris","middle_initials":null,"last_name":"Hovatta","page_name":"IirisHovatta","domain_name":"independent","created_at":"2016-06-11T00:36:19.385-07:00","display_name":"Iiris Hovatta","url":"https://independent.academia.edu/IirisHovatta"},"attachments":[{"id":71167714,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167714/thumbnails/1.jpg","file_name":"ENEURO.0166_18.2018.pdf","download_url":"https://www.academia.edu/attachments/71167714/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Genetic_Control_of_Myelin_Plasticity_aft.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167714/ENEURO.0166_18.2018-libre.pdf?1633319160=\u0026response-content-disposition=attachment%3B+filename%3DGenetic_Control_of_Myelin_Plasticity_aft.pdf\u0026Expires=1733000333\u0026Signature=Nw-GdrtI5VAlBZX0uMn90O8evJOwvm7GzZwpiDI77kSczy7HSNfi6N9wh9Qb-WJzxf5s1BAVSEMooHTJleyGD-R7XzATTY35JBUJ7sUNJJhV9GRKy25fD5qU130J19uDIakuZcfHk9AYJTlBNb1X65Ppq1MDjVtiqhZdX4Ftw5riLNFkUQFvmY5HTAJjfG76pW3f94eiuxAaaEhSWL1Nj5qa4rkqPXAFDyITf1-nGo5G7X8dLPRxjusL4U7VJSqYITpuGSbIIOZaKM3zwkG7nsLjKUUX95IgQ183u99k3qTXMLs3EF5EOEc0dVILKnbTD6PNCVyI2yrDjGjpFuEkIQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55167051"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55167051/Body_mass_index_is_negatively_associated_with_telomere_length_a_collaborative_cross_sectional_meta_analysis_of_87_observational_studies"><img alt="Research paper thumbnail of Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies" class="work-thumbnail" src="https://attachments.academia-assets.com/71167717/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55167051/Body_mass_index_is_negatively_associated_with_telomere_length_a_collaborative_cross_sectional_meta_analysis_of_87_observational_studies">Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies</a></div><div class="wp-workCard_item"><span>The American journal of clinical nutrition</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Even before the onset of age-related diseases, obesity might be a contributing factor to the cumu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. A collaborative cross-sectional meta-analysis of observational studies was conducted to investigate the associations between BMI and TL across the life span. Eighty-seven distinct study samples were included in the meta-analysis capturing data from 146,114 individuals. Study-specific age- and sex-adjusted regression coefficients were combined by using a random-effects model in which absolute [base pairs (bp)] and relative telomere to single-copy gene ratio (T/S ratio) TLs were regressed against BMI. Stratified...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b1347cc9b10e2824655adce164fafa6a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71167717,"asset_id":55167051,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71167717/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55167051"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55167051"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55167051; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55167051]").text(description); $(".js-view-count[data-work-id=55167051]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55167051; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55167051']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55167051, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b1347cc9b10e2824655adce164fafa6a" } } $('.js-work-strip[data-work-id=55167051]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55167051,"title":"Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies","translated_title":"","metadata":{"abstract":"Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. A collaborative cross-sectional meta-analysis of observational studies was conducted to investigate the associations between BMI and TL across the life span. Eighty-seven distinct study samples were included in the meta-analysis capturing data from 146,114 individuals. Study-specific age- and sex-adjusted regression coefficients were combined by using a random-effects model in which absolute [base pairs (bp)] and relative telomere to single-copy gene ratio (T/S ratio) TLs were regressed against BMI. Stratified...","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"The American journal of clinical nutrition"},"translated_abstract":"Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. A collaborative cross-sectional meta-analysis of observational studies was conducted to investigate the associations between BMI and TL across the life span. Eighty-seven distinct study samples were included in the meta-analysis capturing data from 146,114 individuals. Study-specific age- and sex-adjusted regression coefficients were combined by using a random-effects model in which absolute [base pairs (bp)] and relative telomere to single-copy gene ratio (T/S ratio) TLs were regressed against BMI. 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Abno...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Chronic psychosocial stress is a well-established risk factor for neuropsychiatric diseases. Abnormalities in brain activity have been demonstrated in patients with stress-related disorders. Global brain activation patterns during chronic stress exposure are less well understood but may have strong modifying effects on specific brain circuits and thereby influence development of stress-related pathologies. We determined neural activation induced by chronic social defeat stress, a mouse model of psychosocial stress. To assess chronic activation with an unbiased brain-wide focus we used manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemical staining of ∆FOSB, a transcription factor induced by repeated neural activity. One week after 10-day social defeat we observed significantly more activation in several brain regions known to regulate depressive and anxiety-like behaviour, including the prefrontal cortex, bed nucleus of stria terminalis, ventral hippocampus an...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a71a42047bf84030275ba1c2268b9c2b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71167742,"asset_id":55167050,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71167742/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55167050"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55167050"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55167050; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55167050]").text(description); $(".js-view-count[data-work-id=55167050]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55167050; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55167050']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55167050, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a71a42047bf84030275ba1c2268b9c2b" } } $('.js-work-strip[data-work-id=55167050]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55167050,"title":"Brain activation induced by chronic psychosocial stress in mice","translated_title":"","metadata":{"abstract":"Chronic psychosocial stress is a well-established risk factor for neuropsychiatric diseases. Abnormalities in brain activity have been demonstrated in patients with stress-related disorders. Global brain activation patterns during chronic stress exposure are less well understood but may have strong modifying effects on specific brain circuits and thereby influence development of stress-related pathologies. We determined neural activation induced by chronic social defeat stress, a mouse model of psychosocial stress. To assess chronic activation with an unbiased brain-wide focus we used manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemical staining of ∆FOSB, a transcription factor induced by repeated neural activity. One week after 10-day social defeat we observed significantly more activation in several brain regions known to regulate depressive and anxiety-like behaviour, including the prefrontal cortex, bed nucleus of stria terminalis, ventral hippocampus an...","publication_date":{"day":8,"month":1,"year":2017,"errors":{}},"publication_name":"Scientific reports"},"translated_abstract":"Chronic psychosocial stress is a well-established risk factor for neuropsychiatric diseases. Abnormalities in brain activity have been demonstrated in patients with stress-related disorders. Global brain activation patterns during chronic stress exposure are less well understood but may have strong modifying effects on specific brain circuits and thereby influence development of stress-related pathologies. We determined neural activation induced by chronic social defeat stress, a mouse model of psychosocial stress. To assess chronic activation with an unbiased brain-wide focus we used manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemical staining of ∆FOSB, a transcription factor induced by repeated neural activity. One week after 10-day social defeat we observed significantly more activation in several brain regions known to regulate depressive and anxiety-like behaviour, including the prefrontal cortex, bed nucleus of stria terminalis, ventral hippocampus an...","internal_url":"https://www.academia.edu/55167050/Brain_activation_induced_by_chronic_psychosocial_stress_in_mice","translated_internal_url":"","created_at":"2021-10-03T09:21:48.136-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49916833,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71167742,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167742/thumbnails/1.jpg","file_name":"s41598-017-15422-5.pdf","download_url":"https://www.academia.edu/attachments/71167742/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Brain_activation_induced_by_chronic_psyc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167742/s41598-017-15422-5-libre.pdf?1633319156=\u0026response-content-disposition=attachment%3B+filename%3DBrain_activation_induced_by_chronic_psyc.pdf\u0026Expires=1733000333\u0026Signature=M4ce-TiMW2Sdv6oiaZh9hWThGpOfsQC7VUELLP8WBLhVGh7tLylUSM99SsQ1UTLsw2FUq8wUf9FhAIyGw8O-KlV6duiHl4uacrZ5wra~Fb9bedBppsItyCl40XAVgoHGi28000VWiAeozKMNoI~IiMmz33useZ~Jy2aRGxR1S3AhcZ2kvEC00CfkRLzcVKeNZh~tZX9mfnz7uI3FugB~aFd7C3YCzYyRSw1o33lyCMnsxYBKU3I8~01Q5RgO~b-ljVpIwkyUaLGGjw5twQ7tyQ3gFBlvNDZ8YEh9r0CyUESHljXF50MonF9jOtZ9tuOqLKY66WmDpYcliri10FOm6g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Brain_activation_induced_by_chronic_psychosocial_stress_in_mice","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":49916833,"first_name":"Iiris","middle_initials":null,"last_name":"Hovatta","page_name":"IirisHovatta","domain_name":"independent","created_at":"2016-06-11T00:36:19.385-07:00","display_name":"Iiris Hovatta","url":"https://independent.academia.edu/IirisHovatta"},"attachments":[{"id":71167742,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167742/thumbnails/1.jpg","file_name":"s41598-017-15422-5.pdf","download_url":"https://www.academia.edu/attachments/71167742/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Brain_activation_induced_by_chronic_psyc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167742/s41598-017-15422-5-libre.pdf?1633319156=\u0026response-content-disposition=attachment%3B+filename%3DBrain_activation_induced_by_chronic_psyc.pdf\u0026Expires=1733000333\u0026Signature=M4ce-TiMW2Sdv6oiaZh9hWThGpOfsQC7VUELLP8WBLhVGh7tLylUSM99SsQ1UTLsw2FUq8wUf9FhAIyGw8O-KlV6duiHl4uacrZ5wra~Fb9bedBppsItyCl40XAVgoHGi28000VWiAeozKMNoI~IiMmz33useZ~Jy2aRGxR1S3AhcZ2kvEC00CfkRLzcVKeNZh~tZX9mfnz7uI3FugB~aFd7C3YCzYyRSw1o33lyCMnsxYBKU3I8~01Q5RgO~b-ljVpIwkyUaLGGjw5twQ7tyQ3gFBlvNDZ8YEh9r0CyUESHljXF50MonF9jOtZ9tuOqLKY66WmDpYcliri10FOm6g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); 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It is considered a complex trait with onset influenced by both genetic and environmental factors. Identification of genetic risk variants would provide novel insight into the genetic basis of the fear of heights phenotype and contribute to the molecular-level understanding of its aetiology. Genetic isolates may facilitate identification of susceptibility alleles due to reduced genetic heterogeneity. We took advantage of an internal genetic isolate in Finland in which a distinct acrophobia phenotype appears to be segregating in pedigrees originally ascertained for schizophrenia. We conducted parametric, nonparametric, joint linkage and linkage disequilibrium analyses using a microsatellite marker panel, genotyped in families to search for chromosomal regions correlated with acrophobia. Our results implicated a few regions with suggestive evidence for linkage on chromosomes 4q28 (LOD = 2.17), 8q24 (LOD = 2.09) and 13q21-q22 (LOD = 2.22). We observed no risk haplotypes shared between different families. These results suggest that genetic predisposition to acrophobia in this genetic isolate is unlikely to be mediated by a small number of shared high-risk alleles, but rather has a complex genetic architecture. Acrophobia is a pervasive mental disorder, also known as an irrational fear of heights, affecting approximately five percent of the world's population 1. It is a disproportional reaction to a common, rational fear, and can be characterized as apprehension, triggered by elevated spaces or anticipation of them. Acrophobia is classified as a specific phobia under the Diagnostic and Statistical Manual of Mental Disorders (DSM-V), and its aetiology is influenced by both genetic and environmental factors 2,3. While demonstrating high comorbidity rates with various psychiatric disorders and diseases, such as different anxiety disorders or major depression 4,5 , acquisition of acrophobia is believed to differ from other phobias. It may be mediated through a non-associative pathway 6 , rather than conditioning or learning from negative or traumatic experiences 7. The symptoms of individuals suffering from acrophobia involve changes in behavioural, cognitive and physiological functioning, such as confusion and dizziness, when exposed to heights 7. Physiologically associated with anomalies in balance control and avoidance behaviour, acrophobia is a consequence of an underlying biological anomaly involving impaired visual detection of body sway 8. In healthy subjects, posture control is obtained by integrated processing of vestibular, visual and proprioceptive inputs 9. However, in people suffering from acrophobia, dysfunction in one of the feedback mechanisms may lead to increased dependence on other stimuli. In particular, the presence of vestibular dysfunction causes increased dependence on visual or proprioceptive information to keep balance and constant anticipation of matching the natural oscillation of body sway with visual flow stimulation 7. This matching is the root cause of the feeling of lack of stability, especially when exposed to high places 10 .","publication_name":"Scientific Reports","grobid_abstract_attachment_id":71167319},"translated_abstract":null,"internal_url":"https://www.academia.edu/55167048/A_genome_wide_screen_for_acrophobia_susceptibility_loci_in_a_Finnish_isolate","translated_internal_url":"","created_at":"2021-10-03T09:21:48.007-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49916833,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71167319,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167319/thumbnails/1.jpg","file_name":"srep39345.pdf","download_url":"https://www.academia.edu/attachments/71167319/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_genome_wide_screen_for_acrophobia_susc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167319/srep39345-libre.pdf?1633319179=\u0026response-content-disposition=attachment%3B+filename%3DA_genome_wide_screen_for_acrophobia_susc.pdf\u0026Expires=1732856905\u0026Signature=Pn8Ia5vinYxLbTyzLw3lNufKZjX8q7gak8nJHiMNjL28ucJpaCY4DlFRbspb4FxS-ZxefNQBpo2SpqT~eo8Jwqu6~OGdDUkfDvsfcg3df25~tFzWEJ4S3ODDhnchm01mWyB0aac9TG9~8XdHAT2Wv6feImvqKaMwGVGPHj82HkZG8BPlTRaLx0DwWoBlFEHOEa1Bsd653KA9yyx9vbuSSUA~c-W5xLLImNlt0r-HLFAZlIdf6o3jWtspQZa9PExMOfWd8REhQ~XL8lRRtMek5HEDl30x5Iy8Y7U8HTTHOjpQXG6K0s3f~OpnheRy7~2kU7m3oevOYrBEa4On8ZqzPg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_genome_wide_screen_for_acrophobia_susceptibility_loci_in_a_Finnish_isolate","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":49916833,"first_name":"Iiris","middle_initials":null,"last_name":"Hovatta","page_name":"IirisHovatta","domain_name":"independent","created_at":"2016-06-11T00:36:19.385-07:00","display_name":"Iiris Hovatta","url":"https://independent.academia.edu/IirisHovatta"},"attachments":[{"id":71167319,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167319/thumbnails/1.jpg","file_name":"srep39345.pdf","download_url":"https://www.academia.edu/attachments/71167319/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_genome_wide_screen_for_acrophobia_susc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167319/srep39345-libre.pdf?1633319179=\u0026response-content-disposition=attachment%3B+filename%3DA_genome_wide_screen_for_acrophobia_susc.pdf\u0026Expires=1732856905\u0026Signature=Pn8Ia5vinYxLbTyzLw3lNufKZjX8q7gak8nJHiMNjL28ucJpaCY4DlFRbspb4FxS-ZxefNQBpo2SpqT~eo8Jwqu6~OGdDUkfDvsfcg3df25~tFzWEJ4S3ODDhnchm01mWyB0aac9TG9~8XdHAT2Wv6feImvqKaMwGVGPHj82HkZG8BPlTRaLx0DwWoBlFEHOEa1Bsd653KA9yyx9vbuSSUA~c-W5xLLImNlt0r-HLFAZlIdf6o3jWtspQZa9PExMOfWd8REhQ~XL8lRRtMek5HEDl30x5Iy8Y7U8HTTHOjpQXG6K0s3f~OpnheRy7~2kU7m3oevOYrBEa4On8ZqzPg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":71167317,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167317/thumbnails/1.jpg","file_name":"srep39345.pdf","download_url":"https://www.academia.edu/attachments/71167317/download_file","bulk_download_file_name":"A_genome_wide_screen_for_acrophobia_susc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167317/srep39345-libre.pdf?1633319179=\u0026response-content-disposition=attachment%3B+filename%3DA_genome_wide_screen_for_acrophobia_susc.pdf\u0026Expires=1732856905\u0026Signature=Ma2qAhCl1iQ2yxRomrboIv53iT-PniJEb8oUcMpfuWrlRdS6JGNyIWvzTShO4C-26RqvgraDVVugSctD4ovYtxRoefu8lsCddSDatflqLDfCJxmaAHhwujMpSLjoexYC6iE68VreATOwubLqGerx2IkHuk0ZVrzehevgowDtMm6QP9SYTkeZ9pDjIa6DlUFl9rjsuB5zvD7l-txhCNOYdemB9Pe2-bVllMFVLENQ5DoyKRGQViicyy~pygpxJL6mBJN0qAe4ykD5p9jilQ84eSC9hud9yIqFWvK9aGmsvnNTM2h5PinkxaE9RPKxyg1hrOcnq740ZwrEPU1nbJwoog__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":12106873,"url":"http://www.nature.com/articles/srep39345.pdf"}]}, dispatcherData: dispatcherData }); 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However, as childhood maltreatment is a risk factor for depression, it remains unclear whether this may be driving shortened telomere lengths observed amongst depressed patients. Furthermore, it's unclear if the effects of maltreatment on telomere length shortening are more pervasive amongst depressed patients relative to controls, and consequently whether biological ageing may contribute to depression's pathophysiology. The current study assesses the effects of childhood maltreatment, depression case/control status, and the interactive effect of both childhood maltreatment and depression case/ control status on relative telomere length (RTL). Method: DNA samples from 80 depressed subjects and 100 control subjects were utilized from a U.K. sample (ages 20-84), with childhood trauma questionnaire data available for all participants. RTL was quantified using quantitative polymerase chain reactions. Univariate linear regression analyses were used to assess the effects of depression status, childhood maltreatment and depression by childhood maltreatment interactions on RTL. The false discovery rate (q \u003c 0.05) was used for multiple testing correction. Results: Analysis of depression case/control status showed no significant main effect on RTL. Four subtypes of childhood maltreatment also demonstrated no significant main effect on RTL, however a history of physical neglect did significantly predict shorter RTL in adulthood (F(1, 174)=7.559, p=0.007, q=0.042, Variance Explained=4.2%), which was independent of case/control status. RTL was further predicted by severity of physical neglect, with the greatest differences observed in older maltreated individuals (\u003e 50 years old). There were no significant depression case/control status by childhood maltreatment interactions. Limitations: A relatively small sample limited our power to detect interaction effects, and we were unable to consider depression chronicity or recurrence. Conclusion: Shortened RTL was specifically associated with childhood physical neglect, but not the other subtypes of maltreatment or depression case/control status. Our results suggest that the telomere-eroding effects of physical neglect may represent a biological mechanism important in increasing risk for ageing-related disorders. As physical neglect is more frequent amongst depressed cases generally, it may also represent a confounding factor driving previous associations between shorter RTL and depression case status.","publication_date":{"day":null,"month":null,"year":2017,"errors":{}},"publication_name":"Journal of Affective 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class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55167044/Longitudinal_decline_of_leukocyte_telomere_length_in_old_age_and_the_association_with_sex_and_genetic_risk">Longitudinal decline of leukocyte telomere length in old age and the association with sex and genetic risk</a></div><div class="wp-workCard_item"><span>Aging</span><span>, Jan 7, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Telomeres are DNA-protein structures at the ends of chromosomes. Leukocyte telomere length (LTL) ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Telomeres are DNA-protein structures at the ends of chromosomes. Leukocyte telomere length (LTL) shortening has been associated with advanced age. However, most studies use cross-sectional data, hence, the aim of our study was to model longitudinal trajectories of LTL attrition across 20 years at old age. Assessments of LTL were done by qPCR in SATSA (Swedish Adoption/Twin Study of Aging; N=636 individuals). Cross-sectional and longitudinal associations with age were estimated, the latter using latent growth curve analysis. A genetic risk score (GRS) for LTL was further assessed and included in the models. We confirmed an inverse cross-sectional association of LTL with age (B=-0.0022 T/S-ratio; 95% CI: -0.0035, -0.0009, p-value=0.0008). Longitudinal LTL analyses adjusted for sex (1598 samples; ≤5 measurements) suggested modest average decline until 69 years of age but accelerating decline after 69 years, with significant inter-individual variation. Women had on average ~6% T/S-ratio...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="390146b74a684ac2714bb4fc252f85ae" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71167710,"asset_id":55167044,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71167710/download_file?st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55167044"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55167044"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55167044; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55167044]").text(description); $(".js-view-count[data-work-id=55167044]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55167044; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55167044']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55167044, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "390146b74a684ac2714bb4fc252f85ae" } } $('.js-work-strip[data-work-id=55167044]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55167044,"title":"Longitudinal decline of leukocyte telomere length in old age and the association with sex and genetic risk","translated_title":"","metadata":{"abstract":"Telomeres are DNA-protein structures at the ends of chromosomes. 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Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. 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With each cell division, t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Telomeres play an important role in maintaining chromosomal integrity. With each cell division, telomeres are shortened and leukocyte telomere length (LTL) has therefore been considered a marker for biological age. LTL is associated with various lifetime stressors and health-related outcomes. Transgenerational effects have been implicated in newborns, with maternal stress, depression, and anxiety predicting shorter telomere length at birth, possibly reflecting the intrauterine growth environment. Previous studies, with relatively small sample sizes, have reported an effect of maternal stress, BMI, and depression during pregnancy on the LTL of newborns. Here, we attempted to replicate previous findings on prenatal stress and newborn LTL in a sample of 1405 infants using a qPCR-based method. In addition, previous research has been expanded by studying the relationship between maternal sleep quality and LTL. 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With each cell division, telomeres are shortened and leukocyte telomere length (LTL) has therefore been considered a marker for biological age. LTL is associated with various lifetime stressors and health-related outcomes. Transgenerational effects have been implicated in newborns, with maternal stress, depression, and anxiety predicting shorter telomere length at birth, possibly reflecting the intrauterine growth environment. Previous studies, with relatively small sample sizes, have reported an effect of maternal stress, BMI, and depression during pregnancy on the LTL of newborns. Here, we attempted to replicate previous findings on prenatal stress and newborn LTL in a sample of 1405 infants using a qPCR-based method. In addition, previous research has been expanded by studying the relationship between maternal sleep quality and LTL. Maternal prenatal stress, anxiety, depression, BMI, and self-reported sleep qu...","publisher":"Springer Science and Business Media LLC","publication_name":"Scientific Reports"},"translated_abstract":"Telomeres play an important role in maintaining chromosomal integrity. With each cell division, telomeres are shortened and leukocyte telomere length (LTL) has therefore been considered a marker for biological age. LTL is associated with various lifetime stressors and health-related outcomes. Transgenerational effects have been implicated in newborns, with maternal stress, depression, and anxiety predicting shorter telomere length at birth, possibly reflecting the intrauterine growth environment. Previous studies, with relatively small sample sizes, have reported an effect of maternal stress, BMI, and depression during pregnancy on the LTL of newborns. Here, we attempted to replicate previous findings on prenatal stress and newborn LTL in a sample of 1405 infants using a qPCR-based method. In addition, previous research has been expanded by studying the relationship between maternal sleep quality and LTL. Maternal prenatal stress, anxiety, depression, BMI, and self-reported sleep qu...","internal_url":"https://www.academia.edu/55167085/Maternal_stress_or_sleep_during_pregnancy_are_not_reflected_on_telomere_length_of_newborns","translated_internal_url":"","created_at":"2021-10-03T09:21:49.510-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49916833,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71167329,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167329/thumbnails/1.jpg","file_name":"s41598-020-71000-2.pdf","download_url":"https://www.academia.edu/attachments/71167329/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Maternal_stress_or_sleep_during_pregnanc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167329/s41598-020-71000-2-libre.pdf?1633319179=\u0026response-content-disposition=attachment%3B+filename%3DMaternal_stress_or_sleep_during_pregnanc.pdf\u0026Expires=1733000333\u0026Signature=SAbiOmhGphP7LdRAb8aRaHSJR64EsnZ2nme-2VgU6UF9kUOK6WeUVefkxKTtHOxNhmmXxhdKBfAvLSrI9qfPYuvpmSO~jqWkwIjZzJ1VSx7rmBA9H6A3WjZK7~u4iXKvRdVDT0NgD~vAPMvPYKVOB3HkOWil~MRVKaMNxhuKM5SzC-bRvajaFOMvAH1hAl00oJ4A2jzJTr6t0ZBZcWdcW9AtsQTVCb5X0ne-B5hk6ZWNnFMkJS9pChhBR8Lhuk2L-vORF6458ybIeA9XJjSQ~8PYjM3XpRl8ppt7WI7zzdol-MCYW1ZCLJVxCLFGWpdcdBTAREKnhvTi0d2Kth3brA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Maternal_stress_or_sleep_during_pregnancy_are_not_reflected_on_telomere_length_of_newborns","translated_slug":"","page_count":10,"language":"en","content_type":"Work","owner":{"id":49916833,"first_name":"Iiris","middle_initials":null,"last_name":"Hovatta","page_name":"IirisHovatta","domain_name":"independent","created_at":"2016-06-11T00:36:19.385-07:00","display_name":"Iiris Hovatta","url":"https://independent.academia.edu/IirisHovatta"},"attachments":[{"id":71167329,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167329/thumbnails/1.jpg","file_name":"s41598-020-71000-2.pdf","download_url":"https://www.academia.edu/attachments/71167329/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Maternal_stress_or_sleep_during_pregnanc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167329/s41598-020-71000-2-libre.pdf?1633319179=\u0026response-content-disposition=attachment%3B+filename%3DMaternal_stress_or_sleep_during_pregnanc.pdf\u0026Expires=1733000333\u0026Signature=SAbiOmhGphP7LdRAb8aRaHSJR64EsnZ2nme-2VgU6UF9kUOK6WeUVefkxKTtHOxNhmmXxhdKBfAvLSrI9qfPYuvpmSO~jqWkwIjZzJ1VSx7rmBA9H6A3WjZK7~u4iXKvRdVDT0NgD~vAPMvPYKVOB3HkOWil~MRVKaMNxhuKM5SzC-bRvajaFOMvAH1hAl00oJ4A2jzJTr6t0ZBZcWdcW9AtsQTVCb5X0ne-B5hk6ZWNnFMkJS9pChhBR8Lhuk2L-vORF6458ybIeA9XJjSQ~8PYjM3XpRl8ppt7WI7zzdol-MCYW1ZCLJVxCLFGWpdcdBTAREKnhvTi0d2Kth3brA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":71167328,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167328/thumbnails/1.jpg","file_name":"s41598-020-71000-2.pdf","download_url":"https://www.academia.edu/attachments/71167328/download_file","bulk_download_file_name":"Maternal_stress_or_sleep_during_pregnanc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167328/s41598-020-71000-2-libre.pdf?1633319179=\u0026response-content-disposition=attachment%3B+filename%3DMaternal_stress_or_sleep_during_pregnanc.pdf\u0026Expires=1733000333\u0026Signature=bR7GL0QM8ZGUanHAHEEO0vwbRgcWzm1RLo01tytDE4iBFMC-BUl-VbkAhOyXraw--HDIxkoBw9bcSb-A8Iri7YuR5ClSAZzT7MlnhcFmFmA4aFk8HACztMcWpQpctQAazcLuqUlB0OvYI4PAZD3feWVItmdJyIE7c1UNvySVKM73VDf-SUzWGUTS72yvPRtEemxCUJWsAzVsI6BvL-Cwvr804253-AsYOTlvHyBH~0ruRFwhK8xLUnSJbywD2cUCC~DAaBSzIpBxzZoT~T8i-mDtgyj6-WBeTvBsrEPTVV1yx8MTkI0vULkMGLg-ZwQl6yhlEPg~nRthCVRwGJvO9Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":12106884,"url":"http://www.nature.com/articles/s41598-020-71000-2.pdf"}]}, dispatcherData: dispatcherData }); 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b2ba1cc1bae1bcd1968a21d07f955051" } } $('.js-work-strip[data-work-id=55167080]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55167080,"title":"NF‐E2‐related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin‐1 mutated Alzheimer's disease astrocytes","translated_title":"","metadata":{"publisher":"Wiley","grobid_abstract":"Alzheimer's disease (AD) is a common dementia affecting a vast number of individuals and significantly impairing quality of life. Despite extensive research in animal models and numerous promising treatment trials, there is still no curative treatment for AD. Astrocytes, the most common cell type of the central nervous system, have been shown to play a role in the major AD pathologies, including accumulation of amyloid plaques, neuroinflammation, and oxidative stress. Here, we show that inflammatory stimulation leads to metabolic activation of human astrocytes and reduces amyloid secretion. On the other hand, the activation of oxidative metabolism leads to increased reactive oxygen species production especially in AD astrocytes. While healthy astrocytes increase glutathione (GSH) release to protect the cells, Presenilin-1-mutated AD patient astrocytes do not. Thus, chronic inflammation is likely to induce oxidative damage in AD astrocytes. Activation of NRF2, the major regulator of cellular antioxidant defenses, encoded by the NFE2L2 gene, poses several beneficial effects on AD astrocytes. We report here that the activation of NRF2 pathway reduces amyloid secretion, normalizes cytokine release, and increases GSH secretion in AD astrocytes. NRF2 induction also activates the metabolism of astrocytes and increases the utilization of glycolysis. Taken together, targeting NRF2 in astrocytes could be a potent therapeutic strategy in AD.","publication_name":"Glia","grobid_abstract_attachment_id":71167725},"translated_abstract":null,"internal_url":"https://www.academia.edu/55167080/NF_E2_related_factor_2_activation_boosts_antioxidant_defenses_and_ameliorates_inflammatory_and_amyloid_properties_in_human_Presenilin_1_mutated_Alzheimers_disease_astrocytes","translated_internal_url":"","created_at":"2021-10-03T09:21:49.367-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49916833,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71167725,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167725/thumbnails/1.jpg","file_name":"glia.pdf","download_url":"https://www.academia.edu/attachments/71167725/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"NF_E2_related_factor_2_activation_boosts.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167725/glia-libre.pdf?1633319159=\u0026response-content-disposition=attachment%3B+filename%3DNF_E2_related_factor_2_activation_boosts.pdf\u0026Expires=1733000333\u0026Signature=X14Bnu8IJEui357Dx0n7RlHCLnZbCrEEK4FY2ck0CrcVejYW8zRAZp~WHHDLY7ZmzxGWvf7G--ozeMCb-LpOU9omznLjw3v4uekOUaugXuUMBXOXSd0cY-2gOOs8fi3vhT1vPQTlShmtG-fkZu3jHk0F4jQKcCk15ckoZ900OdO2KZz5YKetEQrBaHT9patT2NiRZmY6VOv9DVdTHsmkBLhnZGr8T9PjpWx69L8IQsvt9TQKEt1RDFuiDJnoRkEEF-hwOL~KC~yPciSEOWdtJ66peg1V6gkO~X6LTn4FeftUqNgQ1zX5XsYntyVKB2vGDp8YWIVzL2qRICx69cAp6w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"NF_E2_related_factor_2_activation_boosts_antioxidant_defenses_and_ameliorates_inflammatory_and_amyloid_properties_in_human_Presenilin_1_mutated_Alzheimers_disease_astrocytes","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":49916833,"first_name":"Iiris","middle_initials":null,"last_name":"Hovatta","page_name":"IirisHovatta","domain_name":"independent","created_at":"2016-06-11T00:36:19.385-07:00","display_name":"Iiris Hovatta","url":"https://independent.academia.edu/IirisHovatta"},"attachments":[{"id":71167725,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167725/thumbnails/1.jpg","file_name":"glia.pdf","download_url":"https://www.academia.edu/attachments/71167725/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"NF_E2_related_factor_2_activation_boosts.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167725/glia-libre.pdf?1633319159=\u0026response-content-disposition=attachment%3B+filename%3DNF_E2_related_factor_2_activation_boosts.pdf\u0026Expires=1733000333\u0026Signature=X14Bnu8IJEui357Dx0n7RlHCLnZbCrEEK4FY2ck0CrcVejYW8zRAZp~WHHDLY7ZmzxGWvf7G--ozeMCb-LpOU9omznLjw3v4uekOUaugXuUMBXOXSd0cY-2gOOs8fi3vhT1vPQTlShmtG-fkZu3jHk0F4jQKcCk15ckoZ900OdO2KZz5YKetEQrBaHT9patT2NiRZmY6VOv9DVdTHsmkBLhnZGr8T9PjpWx69L8IQsvt9TQKEt1RDFuiDJnoRkEEF-hwOL~KC~yPciSEOWdtJ66peg1V6gkO~X6LTn4FeftUqNgQ1zX5XsYntyVKB2vGDp8YWIVzL2qRICx69cAp6w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":579707,"name":"Glia","url":"https://www.academia.edu/Documents/in/Glia"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[{"id":12106883,"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/glia.23741"}]}, dispatcherData: dispatcherData }); 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Inbred mouse strains and crosses using them are important reference populations for genetic mapping, and as models of human disease. We determined the nature and extent of interstrain miRNA variation by (i) identifying miRNA SNPs in whole-genome sequence data from 36 strains, and (ii) examining miRNA editing and expression in hippocampus (Hpc) and frontal cortex (FCx) of six strains, to facilitate the study of miRNAs in neurobehavioral phenotypes. miRNA loci were strongly conserved among the 36 strains, but even the highly conserved seed region contained 16 SNPs. In contrast, we identified RNA editing in 58.9% of miRNAs, including 11 consistent editing events in the seed region. We confirmed the functional significance of three conserved edits in the miR-379/410 cluster, demonstrating that edited miRNAs gained novel target mRNAs not recognized by the unedited miRNAs. We found significant interstrain differences in miRNA and isomiR expression: Of 779 miRNAs expressed in Hpc and 719 in FCx, 262 were differentially expressed (190 in Hpc, 126 in FCx, 54 in both). We also identified 32 novel miRNA candidates using miRNA prediction tools. Our studies provide the first comprehensive analysis of SNP, isomiR, and RNA editing variation in miRNA loci across inbred mouse strains, and a detailed catalog of expressed miRNAs in Hpc and FCx in six commonly used strains. 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In order to identify the potential functional mutations alluded to by these previous findings, we sequenced the 1.5Mb of the PDE4D genomic locus in 20 families (consisting of 96 individuals, and 79 independent chromosomes), followed by two stages of genotyping across 6,668 individuals from multiple Finnish cohorts for major mental illnesses. We identified 4,570 SNPs across the PDE4D gene, with 380 associated to schizophrenia (p≤0.05). Importantly, two of these variants, rs35278 and rs165940, are located at transcription factor binding sites, and displayed replicable association in the two-stage enlargement of the familial schizophrenia cohort, (combined statistics for rs35278 p=0.0012; OR=1.18, 95% CI 1.06-1.32; and rs165940 p=0.0016; OR=1.27, 95% CI 1.13-1.41). Further analysis using additional cohorts and endophenotypes revealed that rs165940 principally associates within the psychosis (p=0.025, OR=1.18, 95% CI 1.07-1.30) and cognitive domains of major mental illnesses (g-score p=0.044, beta=-0.033). Specifically, the cognitive domains represented verbal learning and memory (p=0.0091, beta=-0.044) and verbal working memory (p=0.0062, beta=-0.036). Moreover, expression data from the GTEx database demonstrated that rs165940 significantly correlates with the mRNA expression levels of PDE4D in the cerebellum (p-value=0.04; m-value=0.9), demonstrating a potential functional consequence for this variant. Thus, rs165940 represents the most likely functional variant for major mental illness at the PDE4D locus in the Finnish population, increasing risk broadly to psychotic disorders.","publication_name":"Molecular Psychiatry","grobid_abstract_attachment_id":71167715},"translated_abstract":null,"internal_url":"https://www.academia.edu/55167072/Variants_in_regulatory_elements_of_PDE4D_associate_with_major_mental_illness_in_the_Finnish_population","translated_internal_url":"","created_at":"2021-10-03T09:21:49.091-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49916833,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71167715,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167715/thumbnails/1.jpg","file_name":"390518.full.pdf","download_url":"https://www.academia.edu/attachments/71167715/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Variants_in_regulatory_elements_of_PDE4D.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167715/390518.full-libre.pdf?1633319156=\u0026response-content-disposition=attachment%3B+filename%3DVariants_in_regulatory_elements_of_PDE4D.pdf\u0026Expires=1733000333\u0026Signature=cHd3wIAvL-4tUsiDPfyUqgtgkL1rB~DTZ90wHI4afEprOSSN0uyb3lCtAqzRq1Sx~lB6NOQ9oRRLNwPsHhueNI4caLP7np-cQuoBqMaxQgI3fI-xx76UiiQjdkWdxY9F5nlDdGkT4u7nMbHKVBK~iOMBRAwttN9HjF7BQla65OzE6XR2kF3rEOyUQbSJYRbmuxcEms~xCvsbRbWvyIzDAVktjzgQ78N7aNi2p1dLjmvtqEZa~Hd2P0jMWg1uAji70XqvyFhb4gjordN~-RI8awnGVRcZr9onPMS~IE9XWG-rkt5nkZ8gJzLuFp8LGSTRaxtatpmrnCWZ2HjlZm0dLg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Variants_in_regulatory_elements_of_PDE4D_associate_with_major_mental_illness_in_the_Finnish_population","translated_slug":"","page_count":28,"language":"en","content_type":"Work","owner":{"id":49916833,"first_name":"Iiris","middle_initials":null,"last_name":"Hovatta","page_name":"IirisHovatta","domain_name":"independent","created_at":"2016-06-11T00:36:19.385-07:00","display_name":"Iiris Hovatta","url":"https://independent.academia.edu/IirisHovatta"},"attachments":[{"id":71167715,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167715/thumbnails/1.jpg","file_name":"390518.full.pdf","download_url":"https://www.academia.edu/attachments/71167715/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Variants_in_regulatory_elements_of_PDE4D.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167715/390518.full-libre.pdf?1633319156=\u0026response-content-disposition=attachment%3B+filename%3DVariants_in_regulatory_elements_of_PDE4D.pdf\u0026Expires=1733000333\u0026Signature=cHd3wIAvL-4tUsiDPfyUqgtgkL1rB~DTZ90wHI4afEprOSSN0uyb3lCtAqzRq1Sx~lB6NOQ9oRRLNwPsHhueNI4caLP7np-cQuoBqMaxQgI3fI-xx76UiiQjdkWdxY9F5nlDdGkT4u7nMbHKVBK~iOMBRAwttN9HjF7BQla65OzE6XR2kF3rEOyUQbSJYRbmuxcEms~xCvsbRbWvyIzDAVktjzgQ78N7aNi2p1dLjmvtqEZa~Hd2P0jMWg1uAji70XqvyFhb4gjordN~-RI8awnGVRcZr9onPMS~IE9XWG-rkt5nkZ8gJzLuFp8LGSTRaxtatpmrnCWZ2HjlZm0dLg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":32358,"name":"Molecular Psychiatry","url":"https://www.academia.edu/Documents/in/Molecular_Psychiatry"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":12106880,"url":"http://www.nature.com/articles/s41380-019-0429-x.pdf"}]}, dispatcherData: dispatcherData }); 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Correlations Between Insulin Resistance and Peripheral Immunity in First-Episode Psychosis – a Gene Expression Study</a></div><div class="wp-workCard_item"><span>Schizophrenia Bulletin</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55167064"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55167064"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55167064; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55167064]").text(description); $(".js-view-count[data-work-id=55167064]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55167064; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55167064']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55167064, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=55167064]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55167064,"title":"O10.1. Correlations Between Insulin Resistance and Peripheral Immunity in First-Episode Psychosis – a Gene Expression Study","translated_title":"","metadata":{"publisher":"Oxford University Press (OUP)","publication_name":"Schizophrenia Bulletin"},"translated_abstract":null,"internal_url":"https://www.academia.edu/55167064/O10_1_Correlations_Between_Insulin_Resistance_and_Peripheral_Immunity_in_First_Episode_Psychosis_a_Gene_Expression_Study","translated_internal_url":"","created_at":"2021-10-03T09:21:48.748-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49916833,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"O10_1_Correlations_Between_Insulin_Resistance_and_Peripheral_Immunity_in_First_Episode_Psychosis_a_Gene_Expression_Study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":49916833,"first_name":"Iiris","middle_initials":null,"last_name":"Hovatta","page_name":"IirisHovatta","domain_name":"independent","created_at":"2016-06-11T00:36:19.385-07:00","display_name":"Iiris Hovatta","url":"https://independent.academia.edu/IirisHovatta"},"attachments":[],"research_interests":[{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":12106878,"url":"http://academic.oup.com/schizophreniabulletin/article-pdf/45/Supplement_2/S190/28306579/sbz021.249.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55167060"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55167060/Genome_wide_Association_Study_of_Anxiety_and_Stress_related_Disorders_in_the_iPSYCH_Cohort"><img alt="Research paper thumbnail of Genome-wide Association Study of Anxiety and Stress-related Disorders in the iPSYCH Cohort" class="work-thumbnail" src="https://attachments.academia-assets.com/71167712/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55167060/Genome_wide_Association_Study_of_Anxiety_and_Stress_related_Disorders_in_the_iPSYCH_Cohort">Genome-wide Association Study of Anxiety and Stress-related Disorders in the iPSYCH Cohort</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Anxiety and stress-related disorders (ASRD) are among the most common mental disorders with the m...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Anxiety and stress-related disorders (ASRD) are among the most common mental disorders with the majority of patients suffering from additional disorders. Family and twin studies indicate that genetic and environmental factors are underlying their etiology. As ASRD are likely to configure various expressions of abnormalities in the basic stress-response system, we conducted a genome-wide association study including 12,655 cases with various anxiety and stress-related diagnoses and 19,225 controls. Standard association analyses were performed supplemented by a framework of sensitivity analyses. Variants in PDE4B showed consistent association with ASRD across a wide range of our analyses. In mice models, alternations in PDE4B expression were observed in those mice displaying anxious behavior after exposure to chronic stress. We also showed that 28% of the variance in ASRD was accounted for by common variants and that the genetic signature of ASRD overlapped with psychiatric traits, edu...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f3d155f693dde3dd8189f3f36b446cf7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71167712,"asset_id":55167060,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71167712/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55167060"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55167060"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55167060; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55167060]").text(description); $(".js-view-count[data-work-id=55167060]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55167060; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55167060']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55167060, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f3d155f693dde3dd8189f3f36b446cf7" } } $('.js-work-strip[data-work-id=55167060]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55167060,"title":"Genome-wide Association Study of Anxiety and Stress-related Disorders in the iPSYCH Cohort","translated_title":"","metadata":{"abstract":"Anxiety and stress-related disorders (ASRD) are among the most common mental disorders with the majority of patients suffering from additional disorders. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55167055"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/55167055/Gene_environment_interaction_in_myelin_plasticity_after_chronic_psychosocial_stress"><img alt="Research paper thumbnail of Gene-environment interaction in myelin plasticity after chronic psychosocial stress" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/55167055/Gene_environment_interaction_in_myelin_plasticity_after_chronic_psychosocial_stress">Gene-environment interaction in myelin plasticity after chronic psychosocial stress</a></div><div class="wp-workCard_item"><span>European Neuropsychopharmacology</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55167055"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55167055"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55167055; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55167055]").text(description); $(".js-view-count[data-work-id=55167055]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55167055; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55167055']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55167055, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55167052"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55167052/Genetic_Control_of_Myelin_Plasticity_after_Chronic_Psychosocial_Stress"><img alt="Research paper thumbnail of Genetic Control of Myelin Plasticity after Chronic Psychosocial Stress" class="work-thumbnail" src="https://attachments.academia-assets.com/71167714/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55167052/Genetic_Control_of_Myelin_Plasticity_after_Chronic_Psychosocial_Stress">Genetic Control of Myelin Plasticity after Chronic Psychosocial Stress</a></div><div class="wp-workCard_item"><span>eNeuro</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Anxiety disorders often manifest in genetically susceptible individuals after psychosocial stress...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Anxiety disorders often manifest in genetically susceptible individuals after psychosocial stress, but the mechanisms underlying these gene-environment interactions are largely unknown. We used the chronic social defeat stress (CSDS) mouse model to study resilience and susceptibility to chronic psychosocial stress. We identified a strong genetic background effect in CSDS-induced social avoidance (SA) using four inbred mouse strains: 69% of C57BL/6NCrl (B6), 23% of BALB/cAnNCrl, 19% of 129S2/SvPasCrl, and 5% of DBA/2NCrl (D2) mice were stress resilient. Furthermore, different inbred mouse strains responded differently to stress, suggesting they use distinct coping strategies. To identify biological pathways affected by CSDS, we used RNA-sequencing (RNA-seq) of three brain regions of two strains, B6 and D2: medial prefrontal cortex (mPFC), ventral hippocampus (vHPC), and bed nucleus of the stria terminalis (BNST). We discovered overrepresentation of oligodendrocyte (OLG)-related genes...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1ca3d810d4d63ace3aab4a411d942ac7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71167714,"asset_id":55167052,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71167714/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55167052"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55167052"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55167052; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55167052]").text(description); $(".js-view-count[data-work-id=55167052]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55167052; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55167052']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55167052, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1ca3d810d4d63ace3aab4a411d942ac7" } } $('.js-work-strip[data-work-id=55167052]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55167052,"title":"Genetic Control of Myelin Plasticity after Chronic Psychosocial Stress","translated_title":"","metadata":{"abstract":"Anxiety disorders often manifest in genetically susceptible individuals after psychosocial stress, but the mechanisms underlying these gene-environment interactions are largely unknown. 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We discovered overrepresentation of oligodendrocyte (OLG)-related genes...","publication_name":"eNeuro"},"translated_abstract":"Anxiety disorders often manifest in genetically susceptible individuals after psychosocial stress, but the mechanisms underlying these gene-environment interactions are largely unknown. We used the chronic social defeat stress (CSDS) mouse model to study resilience and susceptibility to chronic psychosocial stress. We identified a strong genetic background effect in CSDS-induced social avoidance (SA) using four inbred mouse strains: 69% of C57BL/6NCrl (B6), 23% of BALB/cAnNCrl, 19% of 129S2/SvPasCrl, and 5% of DBA/2NCrl (D2) mice were stress resilient. Furthermore, different inbred mouse strains responded differently to stress, suggesting they use distinct coping strategies. 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We discovered overrepresentation of oligodendrocyte (OLG)-related genes...","internal_url":"https://www.academia.edu/55167052/Genetic_Control_of_Myelin_Plasticity_after_Chronic_Psychosocial_Stress","translated_internal_url":"","created_at":"2021-10-03T09:21:48.338-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49916833,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71167714,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167714/thumbnails/1.jpg","file_name":"ENEURO.0166_18.2018.pdf","download_url":"https://www.academia.edu/attachments/71167714/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Genetic_Control_of_Myelin_Plasticity_aft.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167714/ENEURO.0166_18.2018-libre.pdf?1633319160=\u0026response-content-disposition=attachment%3B+filename%3DGenetic_Control_of_Myelin_Plasticity_aft.pdf\u0026Expires=1733000333\u0026Signature=Nw-GdrtI5VAlBZX0uMn90O8evJOwvm7GzZwpiDI77kSczy7HSNfi6N9wh9Qb-WJzxf5s1BAVSEMooHTJleyGD-R7XzATTY35JBUJ7sUNJJhV9GRKy25fD5qU130J19uDIakuZcfHk9AYJTlBNb1X65Ppq1MDjVtiqhZdX4Ftw5riLNFkUQFvmY5HTAJjfG76pW3f94eiuxAaaEhSWL1Nj5qa4rkqPXAFDyITf1-nGo5G7X8dLPRxjusL4U7VJSqYITpuGSbIIOZaKM3zwkG7nsLjKUUX95IgQ183u99k3qTXMLs3EF5EOEc0dVILKnbTD6PNCVyI2yrDjGjpFuEkIQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Genetic_Control_of_Myelin_Plasticity_after_Chronic_Psychosocial_Stress","translated_slug":"","page_count":16,"language":"en","content_type":"Work","owner":{"id":49916833,"first_name":"Iiris","middle_initials":null,"last_name":"Hovatta","page_name":"IirisHovatta","domain_name":"independent","created_at":"2016-06-11T00:36:19.385-07:00","display_name":"Iiris Hovatta","url":"https://independent.academia.edu/IirisHovatta"},"attachments":[{"id":71167714,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167714/thumbnails/1.jpg","file_name":"ENEURO.0166_18.2018.pdf","download_url":"https://www.academia.edu/attachments/71167714/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Genetic_Control_of_Myelin_Plasticity_aft.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167714/ENEURO.0166_18.2018-libre.pdf?1633319160=\u0026response-content-disposition=attachment%3B+filename%3DGenetic_Control_of_Myelin_Plasticity_aft.pdf\u0026Expires=1733000333\u0026Signature=Nw-GdrtI5VAlBZX0uMn90O8evJOwvm7GzZwpiDI77kSczy7HSNfi6N9wh9Qb-WJzxf5s1BAVSEMooHTJleyGD-R7XzATTY35JBUJ7sUNJJhV9GRKy25fD5qU130J19uDIakuZcfHk9AYJTlBNb1X65Ppq1MDjVtiqhZdX4Ftw5riLNFkUQFvmY5HTAJjfG76pW3f94eiuxAaaEhSWL1Nj5qa4rkqPXAFDyITf1-nGo5G7X8dLPRxjusL4U7VJSqYITpuGSbIIOZaKM3zwkG7nsLjKUUX95IgQ183u99k3qTXMLs3EF5EOEc0dVILKnbTD6PNCVyI2yrDjGjpFuEkIQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55167051"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55167051/Body_mass_index_is_negatively_associated_with_telomere_length_a_collaborative_cross_sectional_meta_analysis_of_87_observational_studies"><img alt="Research paper thumbnail of Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies" class="work-thumbnail" src="https://attachments.academia-assets.com/71167717/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55167051/Body_mass_index_is_negatively_associated_with_telomere_length_a_collaborative_cross_sectional_meta_analysis_of_87_observational_studies">Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies</a></div><div class="wp-workCard_item"><span>The American journal of clinical nutrition</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Even before the onset of age-related diseases, obesity might be a contributing factor to the cumu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. A collaborative cross-sectional meta-analysis of observational studies was conducted to investigate the associations between BMI and TL across the life span. Eighty-seven distinct study samples were included in the meta-analysis capturing data from 146,114 individuals. Study-specific age- and sex-adjusted regression coefficients were combined by using a random-effects model in which absolute [base pairs (bp)] and relative telomere to single-copy gene ratio (T/S ratio) TLs were regressed against BMI. Stratified...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b1347cc9b10e2824655adce164fafa6a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71167717,"asset_id":55167051,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71167717/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55167051"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55167051"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55167051; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55167051]").text(description); $(".js-view-count[data-work-id=55167051]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55167051; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55167051']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55167051, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b1347cc9b10e2824655adce164fafa6a" } } $('.js-work-strip[data-work-id=55167051]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55167051,"title":"Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies","translated_title":"","metadata":{"abstract":"Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. A collaborative cross-sectional meta-analysis of observational studies was conducted to investigate the associations between BMI and TL across the life span. Eighty-seven distinct study samples were included in the meta-analysis capturing data from 146,114 individuals. Study-specific age- and sex-adjusted regression coefficients were combined by using a random-effects model in which absolute [base pairs (bp)] and relative telomere to single-copy gene ratio (T/S ratio) TLs were regressed against BMI. Stratified...","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"The American journal of clinical nutrition"},"translated_abstract":"Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. A collaborative cross-sectional meta-analysis of observational studies was conducted to investigate the associations between BMI and TL across the life span. Eighty-seven distinct study samples were included in the meta-analysis capturing data from 146,114 individuals. Study-specific age- and sex-adjusted regression coefficients were combined by using a random-effects model in which absolute [base pairs (bp)] and relative telomere to single-copy gene ratio (T/S ratio) TLs were regressed against BMI. Stratified...","internal_url":"https://www.academia.edu/55167051/Body_mass_index_is_negatively_associated_with_telomere_length_a_collaborative_cross_sectional_meta_analysis_of_87_observational_studies","translated_internal_url":"","created_at":"2021-10-03T09:21:48.231-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49916833,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71167717,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167717/thumbnails/1.jpg","file_name":"a8e047a39568cdd0070eab4fd4a03fbca322.pdf","download_url":"https://www.academia.edu/attachments/71167717/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Body_mass_index_is_negatively_associated.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167717/a8e047a39568cdd0070eab4fd4a03fbca322-libre.pdf?1633319158=\u0026response-content-disposition=attachment%3B+filename%3DBody_mass_index_is_negatively_associated.pdf\u0026Expires=1733000333\u0026Signature=EY-Jd7vWLPOasw67NgYTgHh2omv2JPOkbAHusWO2PnZfyilkFgrqMuz8bngwpOrPCa1lykOyp9HvghlZLhCyhmaDl8Lm8BibwyOQUOoMhZ-5onNJDafn22G5gsB5FrNut24RsBAQdtyWRLR1YM8OyENfFx1Jfqezlq5x3cEBETpKa3VU7rdSrnLjKIM4KWttwRDT6sypMJhkX81DybEB3pkFI56urlPSzeeBSSJU6~CAjQEYsFtgwztc-CkEBpa~lzvpysSbOIMddSUGoj8AxupdzxHNW~d2RwcSKIVOwUijQ4-2GtOTckvNtRldFkY~cEVTTkwBT8x59hId1pHQYA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Body_mass_index_is_negatively_associated_with_telomere_length_a_collaborative_cross_sectional_meta_analysis_of_87_observational_studies","translated_slug":"","page_count":23,"language":"en","content_type":"Work","owner":{"id":49916833,"first_name":"Iiris","middle_initials":null,"last_name":"Hovatta","page_name":"IirisHovatta","domain_name":"independent","created_at":"2016-06-11T00:36:19.385-07:00","display_name":"Iiris Hovatta","url":"https://independent.academia.edu/IirisHovatta"},"attachments":[{"id":71167717,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167717/thumbnails/1.jpg","file_name":"a8e047a39568cdd0070eab4fd4a03fbca322.pdf","download_url":"https://www.academia.edu/attachments/71167717/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Body_mass_index_is_negatively_associated.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167717/a8e047a39568cdd0070eab4fd4a03fbca322-libre.pdf?1633319158=\u0026response-content-disposition=attachment%3B+filename%3DBody_mass_index_is_negatively_associated.pdf\u0026Expires=1733000333\u0026Signature=EY-Jd7vWLPOasw67NgYTgHh2omv2JPOkbAHusWO2PnZfyilkFgrqMuz8bngwpOrPCa1lykOyp9HvghlZLhCyhmaDl8Lm8BibwyOQUOoMhZ-5onNJDafn22G5gsB5FrNut24RsBAQdtyWRLR1YM8OyENfFx1Jfqezlq5x3cEBETpKa3VU7rdSrnLjKIM4KWttwRDT6sypMJhkX81DybEB3pkFI56urlPSzeeBSSJU6~CAjQEYsFtgwztc-CkEBpa~lzvpysSbOIMddSUGoj8AxupdzxHNW~d2RwcSKIVOwUijQ4-2GtOTckvNtRldFkY~cEVTTkwBT8x59hId1pHQYA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55167050"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55167050/Brain_activation_induced_by_chronic_psychosocial_stress_in_mice"><img alt="Research paper thumbnail of Brain activation induced by chronic psychosocial stress in mice" class="work-thumbnail" src="https://attachments.academia-assets.com/71167742/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55167050/Brain_activation_induced_by_chronic_psychosocial_stress_in_mice">Brain activation induced by chronic psychosocial stress in mice</a></div><div class="wp-workCard_item"><span>Scientific reports</span><span>, Jan 8, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Chronic psychosocial stress is a well-established risk factor for neuropsychiatric diseases. Abno...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Chronic psychosocial stress is a well-established risk factor for neuropsychiatric diseases. Abnormalities in brain activity have been demonstrated in patients with stress-related disorders. Global brain activation patterns during chronic stress exposure are less well understood but may have strong modifying effects on specific brain circuits and thereby influence development of stress-related pathologies. We determined neural activation induced by chronic social defeat stress, a mouse model of psychosocial stress. To assess chronic activation with an unbiased brain-wide focus we used manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemical staining of ∆FOSB, a transcription factor induced by repeated neural activity. One week after 10-day social defeat we observed significantly more activation in several brain regions known to regulate depressive and anxiety-like behaviour, including the prefrontal cortex, bed nucleus of stria terminalis, ventral hippocampus an...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a71a42047bf84030275ba1c2268b9c2b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71167742,"asset_id":55167050,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71167742/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55167050"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55167050"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55167050; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55167050]").text(description); $(".js-view-count[data-work-id=55167050]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55167050; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55167050']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55167050, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a71a42047bf84030275ba1c2268b9c2b" } } $('.js-work-strip[data-work-id=55167050]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55167050,"title":"Brain activation induced by chronic psychosocial stress in mice","translated_title":"","metadata":{"abstract":"Chronic psychosocial stress is a well-established risk factor for neuropsychiatric diseases. Abnormalities in brain activity have been demonstrated in patients with stress-related disorders. Global brain activation patterns during chronic stress exposure are less well understood but may have strong modifying effects on specific brain circuits and thereby influence development of stress-related pathologies. We determined neural activation induced by chronic social defeat stress, a mouse model of psychosocial stress. To assess chronic activation with an unbiased brain-wide focus we used manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemical staining of ∆FOSB, a transcription factor induced by repeated neural activity. One week after 10-day social defeat we observed significantly more activation in several brain regions known to regulate depressive and anxiety-like behaviour, including the prefrontal cortex, bed nucleus of stria terminalis, ventral hippocampus an...","publication_date":{"day":8,"month":1,"year":2017,"errors":{}},"publication_name":"Scientific reports"},"translated_abstract":"Chronic psychosocial stress is a well-established risk factor for neuropsychiatric diseases. Abnormalities in brain activity have been demonstrated in patients with stress-related disorders. Global brain activation patterns during chronic stress exposure are less well understood but may have strong modifying effects on specific brain circuits and thereby influence development of stress-related pathologies. We determined neural activation induced by chronic social defeat stress, a mouse model of psychosocial stress. To assess chronic activation with an unbiased brain-wide focus we used manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemical staining of ∆FOSB, a transcription factor induced by repeated neural activity. One week after 10-day social defeat we observed significantly more activation in several brain regions known to regulate depressive and anxiety-like behaviour, including the prefrontal cortex, bed nucleus of stria terminalis, ventral hippocampus an...","internal_url":"https://www.academia.edu/55167050/Brain_activation_induced_by_chronic_psychosocial_stress_in_mice","translated_internal_url":"","created_at":"2021-10-03T09:21:48.136-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49916833,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71167742,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167742/thumbnails/1.jpg","file_name":"s41598-017-15422-5.pdf","download_url":"https://www.academia.edu/attachments/71167742/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Brain_activation_induced_by_chronic_psyc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167742/s41598-017-15422-5-libre.pdf?1633319156=\u0026response-content-disposition=attachment%3B+filename%3DBrain_activation_induced_by_chronic_psyc.pdf\u0026Expires=1733000333\u0026Signature=M4ce-TiMW2Sdv6oiaZh9hWThGpOfsQC7VUELLP8WBLhVGh7tLylUSM99SsQ1UTLsw2FUq8wUf9FhAIyGw8O-KlV6duiHl4uacrZ5wra~Fb9bedBppsItyCl40XAVgoHGi28000VWiAeozKMNoI~IiMmz33useZ~Jy2aRGxR1S3AhcZ2kvEC00CfkRLzcVKeNZh~tZX9mfnz7uI3FugB~aFd7C3YCzYyRSw1o33lyCMnsxYBKU3I8~01Q5RgO~b-ljVpIwkyUaLGGjw5twQ7tyQ3gFBlvNDZ8YEh9r0CyUESHljXF50MonF9jOtZ9tuOqLKY66WmDpYcliri10FOm6g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Brain_activation_induced_by_chronic_psychosocial_stress_in_mice","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":49916833,"first_name":"Iiris","middle_initials":null,"last_name":"Hovatta","page_name":"IirisHovatta","domain_name":"independent","created_at":"2016-06-11T00:36:19.385-07:00","display_name":"Iiris Hovatta","url":"https://independent.academia.edu/IirisHovatta"},"attachments":[{"id":71167742,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167742/thumbnails/1.jpg","file_name":"s41598-017-15422-5.pdf","download_url":"https://www.academia.edu/attachments/71167742/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Brain_activation_induced_by_chronic_psyc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167742/s41598-017-15422-5-libre.pdf?1633319156=\u0026response-content-disposition=attachment%3B+filename%3DBrain_activation_induced_by_chronic_psyc.pdf\u0026Expires=1733000333\u0026Signature=M4ce-TiMW2Sdv6oiaZh9hWThGpOfsQC7VUELLP8WBLhVGh7tLylUSM99SsQ1UTLsw2FUq8wUf9FhAIyGw8O-KlV6duiHl4uacrZ5wra~Fb9bedBppsItyCl40XAVgoHGi28000VWiAeozKMNoI~IiMmz33useZ~Jy2aRGxR1S3AhcZ2kvEC00CfkRLzcVKeNZh~tZX9mfnz7uI3FugB~aFd7C3YCzYyRSw1o33lyCMnsxYBKU3I8~01Q5RgO~b-ljVpIwkyUaLGGjw5twQ7tyQ3gFBlvNDZ8YEh9r0CyUESHljXF50MonF9jOtZ9tuOqLKY66WmDpYcliri10FOm6g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); 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It is considered a complex trait with onset influenced by both genetic and environmental factors. Identification of genetic risk variants would provide novel insight into the genetic basis of the fear of heights phenotype and contribute to the molecular-level understanding of its aetiology. Genetic isolates may facilitate identification of susceptibility alleles due to reduced genetic heterogeneity. We took advantage of an internal genetic isolate in Finland in which a distinct acrophobia phenotype appears to be segregating in pedigrees originally ascertained for schizophrenia. We conducted parametric, nonparametric, joint linkage and linkage disequilibrium analyses using a microsatellite marker panel, genotyped in families to search for chromosomal regions correlated with acrophobia. Our results implicated a few regions with suggestive evidence for linkage on chromosomes 4q28 (LOD = 2.17), 8q24 (LOD = 2.09) and 13q21-q22 (LOD = 2.22). We observed no risk haplotypes shared between different families. These results suggest that genetic predisposition to acrophobia in this genetic isolate is unlikely to be mediated by a small number of shared high-risk alleles, but rather has a complex genetic architecture. Acrophobia is a pervasive mental disorder, also known as an irrational fear of heights, affecting approximately five percent of the world's population 1. It is a disproportional reaction to a common, rational fear, and can be characterized as apprehension, triggered by elevated spaces or anticipation of them. Acrophobia is classified as a specific phobia under the Diagnostic and Statistical Manual of Mental Disorders (DSM-V), and its aetiology is influenced by both genetic and environmental factors 2,3. While demonstrating high comorbidity rates with various psychiatric disorders and diseases, such as different anxiety disorders or major depression 4,5 , acquisition of acrophobia is believed to differ from other phobias. It may be mediated through a non-associative pathway 6 , rather than conditioning or learning from negative or traumatic experiences 7. The symptoms of individuals suffering from acrophobia involve changes in behavioural, cognitive and physiological functioning, such as confusion and dizziness, when exposed to heights 7. Physiologically associated with anomalies in balance control and avoidance behaviour, acrophobia is a consequence of an underlying biological anomaly involving impaired visual detection of body sway 8. In healthy subjects, posture control is obtained by integrated processing of vestibular, visual and proprioceptive inputs 9. However, in people suffering from acrophobia, dysfunction in one of the feedback mechanisms may lead to increased dependence on other stimuli. In particular, the presence of vestibular dysfunction causes increased dependence on visual or proprioceptive information to keep balance and constant anticipation of matching the natural oscillation of body sway with visual flow stimulation 7. This matching is the root cause of the feeling of lack of stability, especially when exposed to high places 10 .","publication_name":"Scientific Reports","grobid_abstract_attachment_id":71167319},"translated_abstract":null,"internal_url":"https://www.academia.edu/55167048/A_genome_wide_screen_for_acrophobia_susceptibility_loci_in_a_Finnish_isolate","translated_internal_url":"","created_at":"2021-10-03T09:21:48.007-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49916833,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71167319,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167319/thumbnails/1.jpg","file_name":"srep39345.pdf","download_url":"https://www.academia.edu/attachments/71167319/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_genome_wide_screen_for_acrophobia_susc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167319/srep39345-libre.pdf?1633319179=\u0026response-content-disposition=attachment%3B+filename%3DA_genome_wide_screen_for_acrophobia_susc.pdf\u0026Expires=1732856905\u0026Signature=Pn8Ia5vinYxLbTyzLw3lNufKZjX8q7gak8nJHiMNjL28ucJpaCY4DlFRbspb4FxS-ZxefNQBpo2SpqT~eo8Jwqu6~OGdDUkfDvsfcg3df25~tFzWEJ4S3ODDhnchm01mWyB0aac9TG9~8XdHAT2Wv6feImvqKaMwGVGPHj82HkZG8BPlTRaLx0DwWoBlFEHOEa1Bsd653KA9yyx9vbuSSUA~c-W5xLLImNlt0r-HLFAZlIdf6o3jWtspQZa9PExMOfWd8REhQ~XL8lRRtMek5HEDl30x5Iy8Y7U8HTTHOjpQXG6K0s3f~OpnheRy7~2kU7m3oevOYrBEa4On8ZqzPg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_genome_wide_screen_for_acrophobia_susceptibility_loci_in_a_Finnish_isolate","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":49916833,"first_name":"Iiris","middle_initials":null,"last_name":"Hovatta","page_name":"IirisHovatta","domain_name":"independent","created_at":"2016-06-11T00:36:19.385-07:00","display_name":"Iiris Hovatta","url":"https://independent.academia.edu/IirisHovatta"},"attachments":[{"id":71167319,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167319/thumbnails/1.jpg","file_name":"srep39345.pdf","download_url":"https://www.academia.edu/attachments/71167319/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_genome_wide_screen_for_acrophobia_susc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167319/srep39345-libre.pdf?1633319179=\u0026response-content-disposition=attachment%3B+filename%3DA_genome_wide_screen_for_acrophobia_susc.pdf\u0026Expires=1732856905\u0026Signature=Pn8Ia5vinYxLbTyzLw3lNufKZjX8q7gak8nJHiMNjL28ucJpaCY4DlFRbspb4FxS-ZxefNQBpo2SpqT~eo8Jwqu6~OGdDUkfDvsfcg3df25~tFzWEJ4S3ODDhnchm01mWyB0aac9TG9~8XdHAT2Wv6feImvqKaMwGVGPHj82HkZG8BPlTRaLx0DwWoBlFEHOEa1Bsd653KA9yyx9vbuSSUA~c-W5xLLImNlt0r-HLFAZlIdf6o3jWtspQZa9PExMOfWd8REhQ~XL8lRRtMek5HEDl30x5Iy8Y7U8HTTHOjpQXG6K0s3f~OpnheRy7~2kU7m3oevOYrBEa4On8ZqzPg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":71167317,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71167317/thumbnails/1.jpg","file_name":"srep39345.pdf","download_url":"https://www.academia.edu/attachments/71167317/download_file","bulk_download_file_name":"A_genome_wide_screen_for_acrophobia_susc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71167317/srep39345-libre.pdf?1633319179=\u0026response-content-disposition=attachment%3B+filename%3DA_genome_wide_screen_for_acrophobia_susc.pdf\u0026Expires=1732856905\u0026Signature=Ma2qAhCl1iQ2yxRomrboIv53iT-PniJEb8oUcMpfuWrlRdS6JGNyIWvzTShO4C-26RqvgraDVVugSctD4ovYtxRoefu8lsCddSDatflqLDfCJxmaAHhwujMpSLjoexYC6iE68VreATOwubLqGerx2IkHuk0ZVrzehevgowDtMm6QP9SYTkeZ9pDjIa6DlUFl9rjsuB5zvD7l-txhCNOYdemB9Pe2-bVllMFVLENQ5DoyKRGQViicyy~pygpxJL6mBJN0qAe4ykD5p9jilQ84eSC9hud9yIqFWvK9aGmsvnNTM2h5PinkxaE9RPKxyg1hrOcnq740ZwrEPU1nbJwoog__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":12106873,"url":"http://www.nature.com/articles/srep39345.pdf"}]}, dispatcherData: dispatcherData }); 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However, as childhood maltreatment is a risk factor for depression, it remains unclear whether this may be driving shortened telomere lengths observed amongst depressed patients. Furthermore, it's unclear if the effects of maltreatment on telomere length shortening are more pervasive amongst depressed patients relative to controls, and consequently whether biological ageing may contribute to depression's pathophysiology. The current study assesses the effects of childhood maltreatment, depression case/control status, and the interactive effect of both childhood maltreatment and depression case/ control status on relative telomere length (RTL). Method: DNA samples from 80 depressed subjects and 100 control subjects were utilized from a U.K. sample (ages 20-84), with childhood trauma questionnaire data available for all participants. RTL was quantified using quantitative polymerase chain reactions. Univariate linear regression analyses were used to assess the effects of depression status, childhood maltreatment and depression by childhood maltreatment interactions on RTL. The false discovery rate (q \u003c 0.05) was used for multiple testing correction. Results: Analysis of depression case/control status showed no significant main effect on RTL. Four subtypes of childhood maltreatment also demonstrated no significant main effect on RTL, however a history of physical neglect did significantly predict shorter RTL in adulthood (F(1, 174)=7.559, p=0.007, q=0.042, Variance Explained=4.2%), which was independent of case/control status. RTL was further predicted by severity of physical neglect, with the greatest differences observed in older maltreated individuals (\u003e 50 years old). There were no significant depression case/control status by childhood maltreatment interactions. Limitations: A relatively small sample limited our power to detect interaction effects, and we were unable to consider depression chronicity or recurrence. Conclusion: Shortened RTL was specifically associated with childhood physical neglect, but not the other subtypes of maltreatment or depression case/control status. Our results suggest that the telomere-eroding effects of physical neglect may represent a biological mechanism important in increasing risk for ageing-related disorders. As physical neglect is more frequent amongst depressed cases generally, it may also represent a confounding factor driving previous associations between shorter RTL and depression case status.","publication_date":{"day":null,"month":null,"year":2017,"errors":{}},"publication_name":"Journal of Affective 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Rats" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/55167045/A_Potential_Protective_Role_of_RGS2_in_Oxidative_Stress_Mediated_Anxious_Behavior_in_Rats">A Potential Protective Role of RGS2 in Oxidative-Stress Mediated Anxious Behavior in Rats</a></div><div class="wp-workCard_item"><span>The Faseb Journal</span><span>, Apr 1, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55167045"><a 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$('.js-work-strip[data-work-id=55167045]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55167045,"title":"A Potential Protective Role of RGS2 in Oxidative-Stress Mediated Anxious Behavior in Rats","translated_title":"","metadata":{"publication_date":{"day":1,"month":4,"year":2009,"errors":{}},"publication_name":"The Faseb 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class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55167044/Longitudinal_decline_of_leukocyte_telomere_length_in_old_age_and_the_association_with_sex_and_genetic_risk">Longitudinal decline of leukocyte telomere length in old age and the association with sex and genetic risk</a></div><div class="wp-workCard_item"><span>Aging</span><span>, Jan 7, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Telomeres are DNA-protein structures at the ends of chromosomes. Leukocyte telomere length (LTL) ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Telomeres are DNA-protein structures at the ends of chromosomes. Leukocyte telomere length (LTL) shortening has been associated with advanced age. However, most studies use cross-sectional data, hence, the aim of our study was to model longitudinal trajectories of LTL attrition across 20 years at old age. Assessments of LTL were done by qPCR in SATSA (Swedish Adoption/Twin Study of Aging; N=636 individuals). Cross-sectional and longitudinal associations with age were estimated, the latter using latent growth curve analysis. A genetic risk score (GRS) for LTL was further assessed and included in the models. We confirmed an inverse cross-sectional association of LTL with age (B=-0.0022 T/S-ratio; 95% CI: -0.0035, -0.0009, p-value=0.0008). Longitudinal LTL analyses adjusted for sex (1598 samples; ≤5 measurements) suggested modest average decline until 69 years of age but accelerating decline after 69 years, with significant inter-individual variation. Women had on average ~6% T/S-ratio...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="390146b74a684ac2714bb4fc252f85ae" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71167710,"asset_id":55167044,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71167710/download_file?st=MTczMjk5NjczNCw4LjIyMi4yMDguMTQ2&st=MTczMjk5NjczMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55167044"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55167044"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55167044; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55167044]").text(description); $(".js-view-count[data-work-id=55167044]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55167044; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55167044']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55167044, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "390146b74a684ac2714bb4fc252f85ae" } } $('.js-work-strip[data-work-id=55167044]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55167044,"title":"Longitudinal decline of leukocyte telomere length in old age and the association with sex and genetic risk","translated_title":"","metadata":{"abstract":"Telomeres are DNA-protein structures at the ends of chromosomes. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55167041"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55167041/The_transcriptional_landscape_of_age_in_human_peripheral_blood"><img alt="Research paper thumbnail of The transcriptional landscape of age in human peripheral blood" class="work-thumbnail" src="https://attachments.academia-assets.com/71167713/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55167041/The_transcriptional_landscape_of_age_in_human_peripheral_blood">The transcriptional landscape of age in human peripheral blood</a></div><div class="wp-workCard_item"><span>Nature communications</span><span>, Jan 22, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Disease incidences increase with age, but the molecular characteristics of ageing that lead to in...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. 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