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Development of a Tumor Growth-responsive Robust Planning Method for Head and Neck Cancer in Carbon-ion Radiotherapy | Anticancer Research
<!DOCTYPE html> <html lang="en" dir="ltr" xmlns="http://www.w3.org/1999/xhtml" xmlns:mml="http://www.w3.org/1998/Math/MathML"> <head prefix="og: http://ogp.me/ns# article: http://ogp.me/ns/article# book: http://ogp.me/ns/book#" > <!--[if IE]><![endif]--> <link rel="dns-prefetch" href="//cdn.jsdelivr.net" /> <link rel="dns-prefetch" href="//cdn.foxycart.com" /> <link rel="dns-prefetch" href="//scholar.google.com" /> <meta http-equiv="Content-Type" content="text/html; charset=utf-8" /> <meta name="Generator" content="Drupal 7 (http://drupal.org)" /> <link rel="canonical" href="https://ar.iiarjournals.org/content/44/11/5113" /> <link rel="alternate" type="application/pdf" title="Full Text (PDF)" href="/content/44/11/5113.full.pdf" /> <link rel="alternate" type="text/plain" title="Full Text (Plain)" href="/content/44/11/5113.full.txt" /> <link rel="alternate" type="application/vnd.ms-powerpoint" title="Powerpoint" href="/content/44/11/5113.ppt" /> <meta name="article_thumbnail" content="https://ar.iiarjournals.org/content/anticanres/44/11/5113/embed/graphic-5.gif" /> <meta name="issue_cover_image" content="https://ar.iiarjournals.org/sites/default/files/highwire/anticanres/44/11.cover-source.jpg" /> <meta name="type" content="article" /> <meta name="category" content="research-article" /> <meta name="HW.identifier" content="/anticanres/44/11/5113.atom" /> <meta name="HW.pisa" content="anticanres;44/11/5113" /> <meta name="DC.Format" content="text/html" /> <meta name="DC.Language" content="en" /> <meta name="DC.Title" content="Development of a Tumor Growth-responsive Robust Planning Method for Head and Neck Cancer in Carbon-ion Radiotherapy" /> <meta name="DC.Identifier" content="10.21873/anticanres.17336" /> <meta name="DC.Date" content="2024-11-01" /> <meta name="DC.Publisher" content="International Institute of Anticancer Research" /> <meta name="DC.Rights" content="Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved." /> <meta name="DC.AccessRights" content="restricted" /> <meta name="DC.Description" content="Background/Aim: The current study aimed to evaluate a treatment planning method that is robust against tumor growth and to assess its effectiveness in particle therapy for head and neck cancer. Patients and Methods: The proposed method optimizes dose distribution by replacing the relative stopping power ratio (rSPR) of the clinical target volume (CTV) cavity region with a tumor-equivalent rSPR (Condition 1). The optimized initial treatment plan template was then recalculated using in-room CT images acquired in the same treatment position, and the doses to the tumor and organs at risk were compared with those in the initial treatment plan. We evaluated this method in 10 patients with head and neck cancer treated with carbon ion radiotherapy. To evaluate the effectiveness of the proposed method, we compared it to the initial treatment plan without the replacement (Condition 2). Results: CTV V95% reduction relative to that of the initial treatment plan at the end of treatment was 1.3%±2.9% and 2.6%±3.7% for Condition 1 and Condition 2, respectively, with Condition 1 (Replacement condition) providing better CTV coverage. Subgroup analysis showed a higher change in target coverage in the mucosal melanoma than in the adenoid cystic carcinoma, suggesting that this was influenced by the rate of tumor growth. Conclusion: The proposed treatment planning method, which adjusts for tumor growth by modifying the rSPR in the cavity region, improved robustness in carbon ion radiotherapy for head and neck cancer. Condition 1 (with replacement) achieved better CTV coverage than Condition 2 (without replacement), particularly in fast-growing tumors like mucosal melanoma. This method ensures consistent dose delivery to tumors while maintaining safe doses to organs at risk, offering potential for improved treatment outcomes." /> <meta name="DC.Contributor" content="YUYA MIYASAKA" /> <meta name="DC.Contributor" content="YOHSUKE KUSANO" /> <meta name="DC.Contributor" content="NOBUTAKA MIZOGUCHI" /> <meta name="DC.Contributor" content="YOSHIKI TAKAYAMA" /> <meta name="DC.Contributor" content="TADASHI KAMADA" /> <meta name="DC.Contributor" content="TAKEO IWAI" /> <meta name="DC.Contributor" content="HIROYUKI KATOH" /> <meta name="article:published_time" content="2024-11-01" /> <meta name="article:section" content="Clinical Studies" /> <meta name="citation_title" content="Development of a Tumor Growth-responsive Robust Planning Method for Head and Neck Cancer in Carbon-ion Radiotherapy" /> <meta name="citation_abstract" lang="en" content="<p>Background/Aim: The current study aimed to evaluate a treatment planning method that is robust against tumor growth and to assess its effectiveness in particle therapy for head and neck cancer. Patients and Methods: The proposed method optimizes dose distribution by replacing the relative stopping power ratio (rSPR) of the clinical target volume (CTV) cavity region with a tumor-equivalent rSPR (Condition 1). The optimized initial treatment plan template was then recalculated using in-room CT images acquired in the same treatment position, and the doses to the tumor and organs at risk were compared with those in the initial treatment plan. We evaluated this method in 10 patients with head and neck cancer treated with carbon ion radiotherapy. To evaluate the effectiveness of the proposed method, we compared it to the initial treatment plan without the replacement (Condition 2). Results: CTV V95% reduction relative to that of the initial treatment plan at the end of treatment was 1.3%±2.9% and 2.6%±3.7% for Condition 1 and Condition 2, respectively, with Condition 1 (Replacement condition) providing better CTV coverage. Subgroup analysis showed a higher change in target coverage in the mucosal melanoma than in the adenoid cystic carcinoma, suggesting that this was influenced by the rate of tumor growth. Conclusion: The proposed treatment planning method, which adjusts for tumor growth by modifying the rSPR in the cavity region, improved robustness in carbon ion radiotherapy for head and neck cancer. Condition 1 (with replacement) achieved better CTV coverage than Condition 2 (without replacement), particularly in fast-growing tumors like mucosal melanoma. This method ensures consistent dose delivery to tumors while maintaining safe doses to organs at risk, offering potential for improved treatment outcomes.</p>" /> <meta name="citation_journal_title" content="Anticancer Research" /> <meta name="citation_publisher" content="International Institute of Anticancer Research" /> <meta name="citation_publication_date" content="2024/11/01" /> <meta name="citation_mjid" content="anticanres;44/11/5113" /> <meta name="citation_id" content="44/11/5113" /> <meta name="citation_public_url" content="https://ar.iiarjournals.org/content/44/11/5113" /> <meta name="citation_abstract_html_url" content="https://ar.iiarjournals.org/content/44/11/5113.abstract" /> <meta name="citation_full_html_url" content="https://ar.iiarjournals.org/content/44/11/5113.full" /> <meta name="citation_pdf_url" content="https://ar.iiarjournals.org/content/anticanres/44/11/5113.full.pdf" /> <meta name="citation_issn" content="0250-7005" /> <meta name="citation_issn" content="1791-7530" /> <meta name="citation_doi" content="10.21873/anticanres.17336" /> <meta name="citation_pmid" content="39477302" /> <meta name="citation_volume" content="44" /> <meta name="citation_issue" content="11" /> <meta name="citation_article_type" content="Research Article" /> <meta name="citation_section" content="Clinical Studies" /> <meta name="citation_firstpage" content="5113" /> <meta name="citation_lastpage" content="5122" /> <meta name="citation_author" content="YUYA MIYASAKA" /> <meta name="citation_author_institution" content="Department of Heavy Particle Medical Science, Yamagata University Graduate School of Medical Science, Yamagata, Japan;" /> <meta name="citation_author_institution" content="Section of Medical Physics and Engineering, Kanagawa Cancer Center, Yokohama, Japan;" /> <meta name="citation_author" content="YOHSUKE KUSANO" /> <meta name="citation_author_institution" content="Section of Medical Physics and Engineering, Kanagawa Cancer Center, Yokohama, Japan;" /> <meta name="citation_author_email" content="kusano.2270a@kanagawa-pho.jp" /> <meta name="citation_author" content="NOBUTAKA MIZOGUCHI" /> <meta name="citation_author_institution" content="Section of Medical Physics and Engineering, Kanagawa Cancer Center, Yokohama, Japan;" /> <meta name="citation_author" content="YOSHIKI TAKAYAMA" /> <meta name="citation_author_institution" content="Section of Medical Physics and Engineering, Kanagawa Cancer Center, Yokohama, Japan;" /> <meta name="citation_author" content="TADASHI KAMADA" /> <meta name="citation_author_institution" content="Department of Radiation Oncology, Kanagawa Cancer Center, Yokohama, Japan" /> <meta name="citation_author" content="TAKEO IWAI" /> <meta name="citation_author_institution" content="Department of Heavy Particle Medical Science, Yamagata University Graduate School of Medical Science, Yamagata, Japan;" /> <meta name="citation_author" content="HIROYUKI KATOH" /> <meta name="citation_author_institution" content="Department of Radiation Oncology, Kanagawa Cancer Center, Yokohama, Japan" /> <meta name="citation_reference" content="citation_journal_title=Lancet Oncol;citation_author=T. 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Sakurai;citation_title=Dose distribution resulting from changes in aeration of nasal cavity or paranasal sinus cancer in the proton therapy;citation_pages=72-76;citation_volume=113;citation_year=2014;citation_issue=1;citation_pmid=25245554;citation_doi=10.1016/j.radonc.2014.08.024" /> <meta name="twitter:title" content="Development of a Tumor Growth-responsive Robust Planning Method for Head and Neck Cancer in Carbon-ion Radiotherapy" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:image" content="https://ar.iiarjournals.org/sites/default/files/highwire/anticanres/44/11.cover-source.jpg" /> <meta name="twitter:description" content="Background/Aim: The current study aimed to evaluate a treatment planning method that is robust against tumor growth and to assess its effectiveness in particle therapy for head and neck cancer. Patients and Methods: The proposed method optimizes dose distribution by replacing the relative stopping power ratio (rSPR) of the clinical target volume (CTV) cavity region with a tumor-equivalent rSPR (Condition 1). The optimized initial treatment plan template was then recalculated using in-room CT images acquired in the same treatment position, and the doses to the tumor and organs at risk were compared with those in the initial treatment plan. We evaluated this method in 10 patients with head and neck cancer treated with carbon ion radiotherapy. To evaluate the effectiveness of the proposed method, we compared it to the initial treatment plan without the replacement (Condition 2). Results: CTV V95% reduction relative to that of the initial treatment plan at the end of treatment was 1.3%±2.9% and 2.6%±3.7% for Condition 1 and Condition 2, respectively, with Condition 1 (Replacement condition) providing better CTV coverage. Subgroup analysis showed a higher change in target coverage in the mucosal melanoma than in the adenoid cystic carcinoma, suggesting that this was influenced by the rate of tumor growth. Conclusion: The proposed treatment planning method, which adjusts for tumor growth by modifying the rSPR in the cavity region, improved robustness in carbon ion radiotherapy for head and neck cancer. Condition 1 (with replacement) achieved better CTV coverage than Condition 2 (without replacement), particularly in fast-growing tumors like mucosal melanoma. This method ensures consistent dose delivery to tumors while maintaining safe doses to organs at risk, offering potential for improved treatment outcomes." /> <meta name="og-title" property="og:title" content="Development of a Tumor Growth-responsive Robust Planning Method for Head and Neck Cancer in Carbon-ion Radiotherapy" /> <meta name="og-url" property="og:url" content="https://ar.iiarjournals.org/content/44/11/5113" /> <meta name="og-site-name" property="og:site_name" content="Anticancer Research" /> <meta name="og-description" property="og:description" content="Background/Aim: The current study aimed to evaluate a treatment planning method that is robust against tumor growth and to assess its effectiveness in particle therapy for head and neck cancer. Patients and Methods: The proposed method optimizes dose distribution by replacing the relative stopping power ratio (rSPR) of the clinical target volume (CTV) cavity region with a tumor-equivalent rSPR (Condition 1). The optimized initial treatment plan template was then recalculated using in-room CT images acquired in the same treatment position, and the doses to the tumor and organs at risk were compared with those in the initial treatment plan. We evaluated this method in 10 patients with head and neck cancer treated with carbon ion radiotherapy. To evaluate the effectiveness of the proposed method, we compared it to the initial treatment plan without the replacement (Condition 2). Results: CTV V95% reduction relative to that of the initial treatment plan at the end of treatment was 1.3%±2.9% and 2.6%±3.7% for Condition 1 and Condition 2, respectively, with Condition 1 (Replacement condition) providing better CTV coverage. Subgroup analysis showed a higher change in target coverage in the mucosal melanoma than in the adenoid cystic carcinoma, suggesting that this was influenced by the rate of tumor growth. Conclusion: The proposed treatment planning method, which adjusts for tumor growth by modifying the rSPR in the cavity region, improved robustness in carbon ion radiotherapy for head and neck cancer. Condition 1 (with replacement) achieved better CTV coverage than Condition 2 (without replacement), particularly in fast-growing tumors like mucosal melanoma. This method ensures consistent dose delivery to tumors while maintaining safe doses to organs at risk, offering potential for improved treatment outcomes." /> <meta name="og-type" property="og:type" content="article" /> <meta name="og-image" property="og:image" content="https://ar.iiarjournals.org/sites/default/files/highwire/anticanres/44/11.cover-source.jpg" /> <link rel="shortlink" href="/node/82127" /> <link rel="shortcut icon" href="https://ar.iiarjournals.org/sites/default/files/images/favicon.ico" type="image/vnd.microsoft.icon" /> <meta name="viewport" content="width=device-width, initial-scale=1" /> <title>Development of a Tumor Growth-responsive Robust Planning Method for Head and Neck Cancer in Carbon-ion Radiotherapy | Anticancer Research</title> <link type="text/css" rel="stylesheet" href="/sites/default/files/advagg_css/css__QEy_BpbtMcsqv3xURK855GSs2fFjOibU10yA758Mn4c__NucWi_bEk5E3BNVDtTt2nhiPtE1A5I24YwRDQ2fojJ0__M8F9fri-b1QX8RwJbNRiWvN_bqCXCQEG9-9ZZDMJpyg.css" 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class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a"> <div class="highwire-cite-overline"><span class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Clinical Studies</span></span></div> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="anticanres;44/11/5113" data-atom-uri="/anticanres/44/11/5113.atom" data-request-view="full"></span></div> <h1 class="highwire-cite-title" id="page-title">Development of a Tumor Growth-responsive Robust Planning Method for Head and Neck Cancer in Carbon-ion Radiotherapy</h1> <div class="highwire-cite-authors"><span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">YUYA MIYASAKA</span>, <span class="highwire-citation-author" data-delta="1">YOHSUKE KUSANO</span>, <span class="highwire-citation-author" data-delta="2">NOBUTAKA MIZOGUCHI</span>, <span class="highwire-citation-author" data-delta="3">YOSHIKI TAKAYAMA</span>, <span class="highwire-citation-author" data-delta="4">TADASHI KAMADA</span>, <span class="highwire-citation-author" data-delta="5">TAKEO IWAI</span> and <span class="highwire-citation-author" data-delta="6">HIROYUKI KATOH</span></span></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Anticancer Research </span><span class="highwire-cite-metadata-date highwire-cite-metadata">November 2024, </span><span class="highwire-cite-metadata-volume highwire-cite-metadata">44 </span><span class="highwire-cite-metadata-issue highwire-cite-metadata">(11) </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">5113-5122; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.21873/anticanres.17336 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/anticanres/44/11/5113.atom" data-type="link" data-font-icon="" data-parent-id="81985"></span></div> </div> <div id="hw-article-author-popups-top-node-82127--61101525767" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">YUYA MIYASAKA </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>1</span>Department of Heavy Particle Medical Science, Yamagata University Graduate School of Medical Science, Yamagata, Japan;</div><div class='author-affiliation'><span class='nlm-sup'>2</span>Section of Medical Physics and Engineering, Kanagawa Cancer Center, Yokohama, Japan;</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=YUYA%2BMIYASAKA%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=MIYASAKA%20Y&link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AYUYA%2BMIYASAKA%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">YOHSUKE KUSANO </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>2</span>Section of Medical Physics and Engineering, Kanagawa Cancer Center, Yokohama, 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class="author-tooltip-2"><div class="author-tooltip-name">NOBUTAKA MIZOGUCHI </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>2</span>Section of Medical Physics and Engineering, Kanagawa Cancer Center, Yokohama, Japan;</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=NOBUTAKA%2BMIZOGUCHI%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=MIZOGUCHI%20N&link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ANOBUTAKA%2BMIZOGUCHI%2B" rel="nofollow" class="" data-icon-position="" 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Patients and Methods: The proposed method optimizes dose distribution by replacing the relative stopping power ratio (rSPR) of the clinical target volume (CTV) cavity region with a tumor-equivalent rSPR (Condition 1). The optimized initial treatment plan template was then recalculated using in-room CT images acquired in the same treatment position, and the doses to the tumor and organs at risk were compared with those in the initial treatment plan. We evaluated this method in 10 patients with head and neck cancer treated with carbon ion radiotherapy. To evaluate the effectiveness of the proposed method, we compared it to the initial treatment plan without the replacement (Condition 2). Results: CTV V95% reduction relative to that of the initial treatment plan at the end of treatment was 1.3%±2.9% and 2.6%±3.7% for Condition 1 and Condition 2, respectively, with Condition 1 (Replacement condition) providing better CTV coverage. Subgroup analysis showed a higher change in target coverage in the mucosal melanoma than in the adenoid cystic carcinoma, suggesting that this was influenced by the rate of tumor growth. Conclusion: The proposed treatment planning method, which adjusts for tumor growth by modifying the rSPR in the cavity region, improved robustness in carbon ion radiotherapy for head and neck cancer. Condition 1 (with replacement) achieved better CTV coverage than Condition 2 (without replacement), particularly in fast-growing tumors like mucosal melanoma. This method ensures consistent dose delivery to tumors while maintaining safe doses to organs at risk, offering potential for improved treatment outcomes.</p></div><span class="kwd-group-title">Key Words:</span><ul class="kwd-group"><li class="kwd"><a href="/keyword/carbon-ion-radiotherapy-0" class="hw-term hw-article-keyword hw-article-keyword-carbon-ion-radiotherapy" rel="nofollow">Carbon-ion radiotherapy</a></li><li class="kwd"><a href="/keyword/head-and-neck-cancer" class="hw-term hw-article-keyword hw-article-keyword-head-and-neck-cancer" rel="nofollow">head and neck cancer</a></li><li class="kwd"><a href="/keyword/robust-planning" class="hw-term hw-article-keyword hw-article-keyword-robust-planning" rel="nofollow">robust planning</a></li><li class="kwd"><a href="/keyword/tumor-growth" class="hw-term hw-article-keyword hw-article-keyword-tumor-growth" rel="nofollow">tumor growth</a></li><li class="kwd"><a href="/keyword/room-ct" class="hw-term hw-article-keyword hw-article-keyword-in-room-ct" rel="nofollow">in-room CT</a></li></ul><ul class="history-list"><li xmlns:hwp="http://schema.highwire.org/Journal" class="received" hwp:start="2024-08-29"><span class="received-label">Received </span>August 29, 2024.</li><li xmlns:hwp="http://schema.highwire.org/Journal" class="rev-recd" hwp:start="2024-09-17"><span class="rev-recd-label">Revision received </span>September 17, 2024.</li><li xmlns:hwp="http://schema.highwire.org/Journal" class="accepted" hwp:start="2024-09-18"><span class="accepted-label">Accepted </span>September 18, 2024.</li></ul><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright © 2024 International Institute of Anticancer Research (Dr. George J. 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