CINXE.COM

<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd"> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8" /> <title>Development balances cell growth and death :: DNA from the Beginning</title> <meta name="description" content="Normal development requires growth as well as apoptosis, or programmed cell death." /> <link rel="preload" as="style" src="/css/main.css"> <link rel="preload" as="script" src="/js/swfobject.js"> <link rel="preload" as="script" src="/js/prototype-1.6.1.js"> <link href="/css/main.css" rel="stylesheet" type="text/css" /> <link href='https://fonts.googleapis.com/css?family=Droid+Serif' rel='stylesheet' type='text/css'/> <link href='https://fonts.googleapis.com/css?family=Droid+Sans' rel='stylesheet' type='text/css'/> <script type="text/javascript" src="/js/swfobject.js"></script> <script type="text/javascript" src="/js/prototype-1.6.1.js"></script> </head> <body> <div id="container"> <div id="content"> <div id="header"> <div class="rollover-home"> <a href="/" class="rollover-home" title="DNA from the Beginning Home"><span class="displace">Home</span></a> </div> </div>  <div id="content-container"> <h1><span> Concept 38</span> Development balances cell growth and death.</h1> <div id="nav"> <ul> <li class="menu1"><a href="index.html" title="CONCEPT" ><span class="displace">CONCEPT</span></a></li> <li class="menu2"><a href="animation.html" title="ANIMATION"><span class="displace">ANIMATION</span></a></li> <li class="menu3"><a href="gallery.html" title="GALLERY"><span class="displace">GALLERY</span></a></li> <li class="menu4"><a href="av.html" title="VIDEO"><span class="displace">VIDEO</span></a></li> <li class="menu5"><a href="bio.html" title="BIO"><span class="displace">BIO</span></a></li> <li class="menu6"><a href="problem.html" title="PROBLEM"><span class="displace">PROBLEM</span></a></li> <li class="menu7"><a href="links.html" title="LINKS" ><span class="displace">LINKS</span></a></li> </ul> <br class="clearfloat" /> </div> <div id="concept"> <img src="/images/38/concept38.jpg" class="concept-image" alt="Development balances cell growth and death." /> <p>In a biological sense, growth results from the reproduction of new cells from pre-existing ones, by the process of cell division (mitosis). Once a tissue or organ reaches an appropriate size, mitosis slows and cells enter a resting phase. This cell cycle of growth and rest is controlled by "checkpoint" molecules first characterized in the 1980s and 1990s in yeast, and then in other eukaryotes. </p> <p>Remarkably, normal development requires that some healthy cells be eliminated, killed, by a process called "apoptosis." Initial clues about the nature of apoptosis came from detailed studies of the roundworm <em>Caenorhabditis elegans</em>, in which development of each of the 959 cells in the adult can be traced from the fertilized egg. Analysis of cell "fates" showed that specific cells are programmed to die at specific times during embryonic development. Disruptions in the program lead to an overabundance of cells — a hallmark of cancer.</p> </div> </div> <br class="clearfloat" /> <div id="footer"> <ul> <li><a href="/">Home</a></li> <li><a href="/sitemap.html">Site Map</a></li> <li><a href="/scientists.html">Scientists</a></li> <li><a href="/glossary.html">Glossary</a></li> <li><a href="/feedback.html">Feedback</a></li> <li><a href="/awards.html">Awards</a></li> <li><a href="/credits.html">Credits</a></li> <li><a href="http://blogs.dnalc.org/dnaftb/" style="background-image:none;">Blog</a></li> </ul> <p> Funded by <a href="http://macyfoundation.org">The Josiah Macy, Jr. Foundation</a><br /> © 2002 - 2011, <a href="http://www.dnalc.org/"> DNA Learning Center</a>, <a href="https://www.cshl.edu/">Cold Spring Harbor Laboratory</a>. All rights reserved. </p> </div>  </div> <div id="sidebar"> <div id="search" > <form method="get" action="/search"> <div class="fieldHolder1"> <input type="search" id="q" name="q" placeholder="Search" onclick="this.value=''" value="" /> <img style="background-color:#9C0;" src="/images/general/search_icon.jpg" alt="Search" onclick="document.forms[0].submit()" /> </div> </form> </div>  <div id="sidebar"> <ul class="menu-side" > <li class="section1"><a href="/1/index.html" title="Classical Genetics"><span class="displace">CLASSICAL GENETICS</span></a></li> <li class="section2" style="margin-bottom: 3px;"><a href="/15/index.html" title="Molecules of Genetics"><span class="displace">MOLECULES OF GENETICS</span></a></li>  </ul> <ul class="sections-side sections-side3a" style="padding-top: 56px;" > <li ><a href="/29/"><img src="/images/thumbnails/29-thumb-sm.png" alt="29." />DNA is packaged in a chromosome.</a></li> <li ><a href="/30/"><img src="/images/thumbnails/30-thumb-sm.png" alt="30." />Higher cells incorporate an ancient chromosome.</a></li> <li ><a href="/31/"><img src="/images/thumbnails/31-thumb-sm.png" alt="31." />Some DNA does not encode protein.</a></li> <li ><a href="/32/"><img src="/images/thumbnails/32-thumb-sm.png" alt="32." />Some DNA can jump.</a></li> <li ><a href="/33/"><img src="/images/thumbnails/33-thumb-sm.png" alt="33." />Genes can be turned on and off.</a></li> <li ><a href="/34/"><img src="/images/thumbnails/34-thumb-sm.png" alt="34." />Genes can be moved between species.</a></li> <li ><a href="/35/"><img src="/images/thumbnails/35-thumb-sm.png" alt="35." />DNA responds to signals from outside the cell.</a></li> <li ><a href="/36/"><img src="/images/thumbnails/36-thumb-sm.png" alt="36." />Different genes are active in different kinds of cells.</a></li> <li ><a href="/37/"><img src="/images/thumbnails/37-thumb-sm.png" alt="37." />Master genes control basic body plans.</a></li> <li ><a class="concept-highlight" href="/38/"><img src="/images/thumbnails/38-thumb-sm.png" alt="38." />Development balances cell growth and death.</a></li> <li ><a href="/39/"><img src="/images/thumbnails/39-thumb-sm.png" alt="39." />A genome is an entire set of genes.</a></li> <li ><a href="/40/"><img src="/images/thumbnails/40-thumb-sm.png" alt="40." />Living things share common genes.</a></li> <li style="border-bottom: 1px solid #669;"><a href="/41/"><img src="/images/thumbnails/41-thumb-sm.png" alt="41." />DNA is only the beginning for understanding the human genome.</a></li> </ul> </div>  </div>  <br class="clearfloat" /> </div>  <script type="text/javascript"> Event.observe(window, 'load', function() { var uri = '/38/index.html'; uri = uri.replace(/-\d/,''); $('nav').down().descendants().each(function(s) { if (s.nodeName == 'A') { if (s.href.match(uri)) { s.addClassName('current'); throw $break; } } }); }); </script> <script type="text/javascript"> var _gaq = _gaq || []; _gaq.push(['_setAccount', 'UA-1818773-10']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = 'https://www.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); </script>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-K6EHFCRJBP"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-K6EHFCRJBP'); </script> </body> </html>