Immunology Research | Bio-Techne

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<div> <div id="block-bio-techne-global-breadcrumbs" class="system_breadcrumb_block"> <nav role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/research-areas">Research Areas</a> </li> <li> Immunology Research </li> </ol> </nav> </div> </div> </div> </div> <main> <section class="section"> <div> <div id="block-bio-techne-global-content" class="system_main_block"> <article> <div> <div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--_-2-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_header_2_global"> <div><h2>Immunology Research Products and Resources</h2></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><p>Research in immunology seeks to elucidate the form and function of organismal defense mechanisms. Immunity, defined as a physiological response to foreign agents aimed at maintaining homeostasis, is mediated by a complex array of humoral (e.g., secreted antibodies and complement) and cellular mechanisms which have been classified under innate or adaptive immunity. Innate immunity is rapidly activated following exposure to foreign agents (e.g., bacteria and viruses), and represents a first line of defense, but lacks specificity. In contrast, adaptive immunity is engaged at a later time and involves receptors with the capacity to rearrange and recognize an almost infinite number of non-self antigens.</p><h2>Table of Contents</h2><ul><li><a href="#Immunology Disease Types">Immunology Disease Types </a></li><li><a href="#Immunology Research Areas">Immunology Research Areas</a></li><li><a href="#Immunology Product Targets">Immunology Targets </a></li><li><a href="#Products and Services">Products and Services</a></li><li><a href="#Immunology Resources & Tools">Immunology Resources & Tools</a></li><li><a href="#Background and FAQs">Background and FAQs</a></li></ul></div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/immunology-cell-identity-markers-fig-4.jpeg" alt="Gamma Delta T and NK T cells bridge innate and adaptive immunity" loading="lazy" > </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2><a name="Immunology Disease Types"></a>Immunology Disease Types</h2><p>Browse research products by immunology disease type:<br> </p><figure class="responsive-figure-table"><table class="table table-bordered overflow-auto"><tbody><tr><td class="w-25"><a href="/research-areas/immunology/immunology-of-infectious-diseases">Infectious Diseases</a></td><td class="w-25"><a href="https://www.rndsystems.com/research-area/allergy--asthma-and-inflammation">Allergy, Asthma and Inflammation</a> (at R&D Systems) </td><td class="w-25"><a href="https://www.tocris.com/research-area/arthritis-research" target="_blank">Arthritis</a> (at Tocris)</td><td><a href="https://www.tocris.com/research-area/multiple-sclerosis" target="_blank">Multiple Sclerosis</a> (at Tocris)</td></tr><tr><td><a href="https://www.rndsystems.com/research-area/nod--like-receptors-and-the-inflammasome" target="_blank">Autoinflammatory Diseases</a> (at R&D Systems)</td><td><a href="https://www.rndsystems.com/research-area/atherosclerosis">Atherosclerosis</a> (at R&D Systems)</td><td class="w-25"><a href="https://www.rndsystems.com/research-area/hematologic-cancers">Hematologic Cancers</a> (at R&D Systems)</td><td> </td></tr></tbody></table></figure><p> </p></div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2><a name="Immunology Research Areas"></a>Immunology Research Areas</h2><p>Browse research products by immunology research area:</p><figure class="responsive-figure-table"><table class="table table-striped"><tbody><tr><td class="w-25"><a href="/research-areas/immunology/adaptive-immunity">Adaptive Immunity</a> </td><td class="w-25"><a href="/t/antibiotics">Antibiotics</a></td><td class="w-25"><a href="/search?search_type=products&keywords=Antivirals">Antivirals </a></td><td><a href="/research-areas/immunology/b-cell-development-and-differentiation-markers">B-Cell Development</a></td></tr><tr><td class="w-25"><a href="https://www.rndsystems.com/research-area/cells-of-the-immune-system">Cells of the Immune System</a> (at R&D Systems)</td><td><a href="https://www.rndsystems.com/research-area/complement-pathway" target="_blank">Complement System</a> (at R&D Systems)</td><td><a href="/reagents/proteins/cytokines">Cytokines & Receptors</a></td><td><a href="https://www.rndsystems.com/research-area/host-defense-innate-immunity">Host Defense/Innate Immunity</a> (at R&D Systems)</td></tr><tr><td><a href="/research-areas/immunology/immune-cell-identification-and-characterization">Immune Cell Characterization</a></td><td><a href="/research-areas/immunology/immune-cell-modulation-and-function">Immune Cell Modulation & Function</a></td><td><a href="/research-areas/immunology/immune-cell-selection-and-culture">Immune Cell Selection & Culture</a></td><td><a href="https://www.rndsystems.com/research-area/signal-transduction" target="_blank">Immune Cell Signaling</a>  (at R&D Systems)</td></tr><tr><td><a href="/research-areas/immune-cell-therapy">Immune Cell Therapy</a></td><td><a href="/reagents/proteins/immune-checkpoint-proteins">Immune Checkpoints</a></td><td><a href="/research-areas/immunology/immune-response-analysis">Immune Response Analysis</a></td><td><a href="https://www.rndsystems.com/research-area/immune-system-development" target="_blank">Immune System Development </a>(at R&D Systems)</td></tr><tr><td><a href="https://www.rndsystems.com/resources/cell-markers/immune-cells" target="_blank">Immunology Cell Identity Markers</a> (at R&D Systems)</td><td><a href="/research-areas/immuno-oncology">Immuno-Oncology</a></td><td><a href="/search?search_type=products&keywords=Immunosuppressants">Immunosuppressants</a></td><td><a href="/research-areas/immunology/immunology-of-infectious-diseases">Infectious diseases</a> </td></tr><tr><td><a href="/search?search_type=products&keywords=inflammasomes+">Inflammasomes</a> </td><td><a href="https://www.rndsystems.com/research-area/inflammation" target="_blank">Inflammation</a> (at R&D Systems)</td><td><a href="/research-areas/immunology/innate-immunity-cell-markers">Innate Immunity </a></td><td><a href="https://www.rndsystems.com/resources/cell-markers/immune-cells/innate-lymphoid-cells" target="_blank">Innate Lymphoid Cells</a> (at R&D Systems)</td></tr><tr><td><a href="/research-areas/immunology/myeloid-derived-suppressor-cell-markers">Myeloid-derived Suppressor Cells (MDSC)</a> </td><td><a href="https://www.rndsystems.com/research-area/pattern-recognition-receptors" target="_blank">Pattern Recognition Receptors</a> (at R&D Systems)</td><td> </td><td> </td></tr></tbody></table></figure></div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2><a name="Immunology Product Targets"></a>Immunology Product Targets</h2><h4>Featured Immunology Targets</h4><figure class="responsive-figure-table"><table class="table table-striped"><tbody><tr><td><a href="/t/antibiotics" target="_parent">Antibiotics</a></td><td><a href="/search?search_type=products&keywords=Complement+system" target="_parent">Complement system </a></td><td><a href="/reagents/proteins/cytokines/il-1-family" target="_parent">IL-1 Family</a></td><td class="w-25"><a href="/t/sting-tmem173" target="_parent">STING</a></td></tr><tr><td><a href="/t/complement-component-c5ar1" target="_parent">C5a Receptor</a></td><td><a href="/reagents/proteins/cytokines" target="_parent">Cytokines</a></td><td><a href="/search?search_type=products&keywords=Inflammasomes" target="_parent">Inflammasomes</a></td><td><a href="/reagents/proteins/growth-factors/tgf-beta-superfamily" target="_parent">TGF-beta Superfamily</a></td></tr><tr><td><a href="/reagents/proteins/cytokines/chemokines" target="_parent">Chemokines and Receptors</a></td><td><a href="/search?search_type=products&keywords=histamine+receptors" target="_parent">Histamine Receptors</a></td><td><a href="/reagents/proteins/cytokines/interferons" target="_parent">Interferons</a></td><td><a href="/reagents/proteins/cytokines/tnf-superfamily" target="_parent">TNF Superfamily</a></td></tr></tbody></table></figure></div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-view-full-list-of-immunology-targets21" role="button" aria-expanded="false" aria-controls="expPara"> <h5>View Full List of Immunology Targets</h5> </a> </div> <div class="collapse" id="expPara-view-full-list-of-immunology-targets21" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><h3>Antivirals</h3><figure class="responsive-figure-table"><table class="table table-striped"><tbody><tr><td><a href="/t/antiviral-compounds" target="_parent">Antivirals</a></td><td colspan="2"><a href="/t/dengue-virus-2-ns1" target="_parent">Dengue Virus</a></td><td><a href="/search?search_type=products&keywords=Influenza+A+Virus" target="_parent">Influenza A Virus</a></td><td><a href="/search?search_type=products&keywords=Varicella-Zoster+Virus" target="_parent">Varicella-Zoster Virus</a></td></tr><tr><td><a href="/search?search_type=products&keywords=Coronaviruses" target="_parent">Coronaviruses</a></td><td><a href="/search?search_type=products&keywords=Flaviviruses" target="_parent">Flaviviruses</a></td><td> </td><td><a href="/search?search_type=products&keywords=Poliovirus" target="_parent">Poliovirus</a></td><td><a href="/t/wnvns3-protease" target="_parent">West Nile Virus</a></td></tr><tr><td><a href="/search?search_type=products&keywords=Coxsackievirus+and+Adenovirus" target="_parent">Coxsackievirus and Adenovirus</a></td><td><a href="/search?search_type=products&keywords=Henipavirus" target="_parent">Henipavirus</a></td><td> </td><td><a href="/search?search_type=products&keywords=Poxvirus" target="_parent">Poxvirus</a></td><td><a href="/t/zika-virus-igg" target="_parent">Zika Virus</a></td></tr><tr><td><a href="/search?search_type=products&keywords=Cytomegalovirus" target="_parent">Cytomegalovirus</a></td><td colspan="2"><a href="/search?search_type=products&keywords=Herpes+Simplex+Viruses" target="_parent">Herpes Simplex Viruses</a></td><td><a href="/search?search_type=products&keywords=SARS" target="_parent">SARS</a></td><td class="w-25"> </td></tr></tbody></table></figure><h3> </h3><h3>Immune Cells</h3><figure class="responsive-figure-table"><table class="table table-striped"><tbody><tr><td><a href="/research-areas/immunology/b-cell-development-and-differentiation-markers" target="_parent">B-Cells</a></td><td><a href="/search?search_type=products&keywords=dendritic+cells" target="_parent">Dendritic cells</a></td><td><a href="/research-areas/immune-cell-therapy/nk-cells" target="_parent">Natural Killer Cells</a></td><td class="w-25"><a href="/search?search_type=products&keywords=Macrophages" target="_parent">Macrophages</a></td></tr><tr><td><a href="/search?search_type=products&keywords=Basophils" target="_parent">Basophils</a></td><td><a href="/search?search_type=products&keywords=Eosinophils" target="_parent">Eosinophils</a></td><td><a href="/search?search_type=products&keywords=Neutrophils" target="_parent">Neutrophils</a></td><td><a href="/research-areas/immunology/myeloid-derived-suppressor-cell-markers" target="_parent">Myeloid-derived Suppressor Cells</a></td></tr><tr><td><a href="/research-areas/immune-cell-therapy/t-cell-manufacturing">T cells</a></td><td><a href="/search?search_type=products&keywords=Monocytes">Monocytes</a></td><td><a href="/search?search_type=products&keywords=Mast+Cells">Mast Cells</a></td><td><a href="/t/cd4">CD4+ T Cells</a></td></tr><tr><td><a href="/t/cd8">CD8+ T Cells</a></td><td> </td><td> </td><td> </td></tr></tbody></table></figure><p> </p><h3>Immune Cell Signaling </h3><figure class="responsive-figure-table"><table class="table table-striped"><tbody><tr><td><a href="/t/inos" target="_parent">iNOS</a></td><td class="w-25"><a href="/t/jnk" target="_parent">JNK</a></td><td><a href="/search?search_type=products&keywords=Raf" target="_parent">Raf</a></td><td><a href="/search?search_type=products&keywords=STAT" target="_parent">STAT</a></td></tr><tr><td><a href="/search?search_type=products&keywords=JAK" target="_parent">JAK</a></td><td><a href="/search?search_type=products&keywords=p38" target="_parent">p38</a></td><td><a href="/t/src" target="_parent">Src</a></td><td class="w-25"><a href="/t/syk" target="_parent">Syk</a></td></tr></tbody></table></figure><h3> </h3><h3>General Immunology Targets</h3><figure class="responsive-figure-table"><table class="table table-striped"><tbody><tr><td class="w-25"><a href="/t/antibiotics" target="_parent">Antibiotics</a></td><td class="w-25"><a href="/search?search_type=products&keywords=Cyclooxygenase" target="_parent">Cyclooxygenase</a><a href="/search?search_type=products&keywords=Cyclooxygenase"> (COX)</a></td><td class="w-25"><a href="/reagents/proteins/cytokines/il-17-family" target="_parent">IL-17 Family</a></td><td><a href="/search?search_type=products&keywords=+Interleukins+and+Receptors" target="_parent">Other Interleukins and Receptors</a></td></tr><tr><td><a href="/search?search_type=products&keywords=Adhesion+Molecules" target="_parent">Adhesion Molecules</a></td><td><a href="/reagents/proteins/cytokines" target="_parent">Cytokines</a></td><td><a href="/reagents/elisa-kits/immune-checkpoint-assays" target="_parent">Immune Checkpoint Immunoassays </a></td><td><a href="/search?search_type=products&keywords=Pattern+Recognition+Receptors" target="_parent">Pattern Recognition Receptors</a></td></tr><tr><td><a href="/search?search_type=products&keywords=Anthrax" target="_parent">Anthrax</a></td><td><a href="/search?search_type=products&keywords=EGF+Family" target="_parent">EGF Family</a></td><td><a href="/reagents/proteins/immune-checkpoint-proteins#immune-checkpoint" target="_parent">Immune Checkpoint Proteins</a></td><td><a href="/search?search_type=products&keywords=Regulatory+T+cells" target="_parent">Regulatory T Cells (T<sub>regs</sub>)</a></td></tr><tr><td><a href="/t/complement-component-c5ar1" target="_parent">C5a receptor</a></td><td><a href="/reagents/proteins/growth-factors/fgf-superfamily" target="_parent">FGF Family</a></td><td><a href="/search?search_type=products&keywords=IL-17+Family" target="_parent">Immunosuppressants</a></td><td><a href="/t/sting-tmem173" target="_parent">STING/TMEM173</a></td></tr><tr><td><a href="/search?keywords=caspase" target="_parent">Caspases</a></td><td><a href="/t/glucocorticoid-receptor-compounds" target="_parent">Glucocorticoid Receptors</a></td><td><a href="/search?search_type=products&keywords=Inflammasomes" target="_parent">Inflammasomes</a></td><td><a href="/reagents/proteins/growth-factors/tgf-beta-superfamily" target="_parent">TGF-β Superfamily</a></td></tr><tr><td><a href="/research-areas/cell-biology/cell-markers" target="_parent">Cell Markers</a> (more Immune Cell Markers found at <a href="https://www.rndsystems.com/resources/cell-markers/immune-cells" target="_blank">R&D Systems</a>)</td><td><a href="/search?search_type=products&keywords=histamine+receptors" target="_parent">Histamine Receptors</a></td><td><a href="/search?search_type=products&keywords=Integrins" target="_parent">Integrins</a></td><td><a href="/reagents/proteins/cytokines/tnf-superfamily" target="_parent">TNF Superfamily</a></td></tr><tr><td><a href="/reagents/proteins/cytokines/chemokines" target="_parent">Chemokines and Receptors</a></td><td><a href="/reagents/proteins/cytokines/il-1-family" target="_parent">IL-1 Family</a></td><td><a href="/reagents/proteins/cytokines/interferons" target="_parent">Interferons</a></td><td><a href="/research-areas/immunology/toll-receptors-tlr" target="_parent">Toll-like Receptors (TLRs)</a></td></tr><tr><td><a href="/search?keywords=recombinant%20protein&common_name=IL-3|IL-5|GM-CSF" target="_parent">Common Beta Chain Receptor Family</a></td><td><a href="/reagents/proteins/cytokines/il-6-family" target="_parent">IL-6 Family</a></td><td><a href="/search?search_type=products&keywords=Lysosomal+Enzymes" target="_parent">Lysosomal Enzymes</a></td><td><a href="/search?search_type=products&keywords=Tumor+Associated+Macrophages" target="_parent">Tumor Associated Macrophages (TAMs)</a></td></tr><tr><td><a href="/reagents/proteins/cytokines/common-cytokine-receptor-gamma-chain-family" target="_parent">Common Gamma Chain Receptor Family</a></td><td><a href="/reagents/proteins/cytokines/il-10-family" target="_parent">IL-10 Family</a></td><td><a href="/search?search_type=products&keywords=NF-κB+" target="_parent">NF-κB Signaling Pathways</a></td><td> </td></tr><tr><td><a href="https://www.rndsystems.com/research-area/complement-pathway" target="_blank">Complement system </a>(at R&D Systems)</td><td><a href="/reagents/proteins/cytokines/il-12-family" target="_parent">IL-12 Family</a></td><td><a href="/reagents/proteins/growth-factors/notch-family" target="_parent">Notch Family</a></td><td> </td></tr></tbody></table></figure><p> </p></div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--clickable-icons-container paragraph--view-mode--default"> <div class="container"> <div class="row"> <div class="col p-0 "> <h2>Products and Services</h2> </div> </div> <div class="row"> <div class="col "> </div> </div> <div class="row"> <div class="row"> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="/reagents/proteins/immune-cell-culture-proteins" > <div><article> <div><img src='https://resources.bio-techne.com/bio-techne-assets/images/products/br-protein-product-table-icon-v2-250x250.png' alt='icon of Protein Product Table'></div> </article> </div> <p><strong>Proteins</strong></p> 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are effected by distinct subsets of cellular mediators. Innate mediators express receptors that recognize foreign molecular patterns, allowing the rapid targeting of pathogens (e.g., by phagocytosis). In comparison to innate responses, engagement of adaptive immunity occurs with a delay, but B and T cell receptors allow the identification of a broad diversity of antigens, making adaptive responses highly specific.</p><p>Extensive cross talk, via both humoral and cellular mediators, occurs between these two immune modalities. While innate immunity lacks memory and therefore is unable to improve with experience, the ability of innate cells to stimulate and modulate adaptive responses (e.g., through antigen presentation) makes this branch of immunity essential for mounting an effective response.</p></div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/innate-adaptive-response.jpg" alt="Innate Adaptive Response diagram" loading="lazy" > </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-car-t-cell-killing-mechanisms13" role="button" aria-expanded="false" aria-controls="expPara"> <h5>CAR-T Cell Killing Mechanisms</h5> </a> </div> <div class="collapse" id="expPara-car-t-cell-killing-mechanisms13" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/car-t-cell-killing.jpg" alt="CAR-T Cell Killing image" loading="lazy" > </div> <br/> <div><p>Application of basic immunological principles has supported rapid growth in the development of immunotherapy strategies, particularly for cancer treatment. Among these, the development of Chimeric Antigen Receptor-T cell (CAR-T) based therapies, which rely on the genetic manipulation of T cells to express antibody-based chimeric receptors to efficiently target tumor antigens, have significantly transformed the approach to cancer treatment. </p></div> <a href="/resources/ebook/immuno-oncology" class="btn btn-primary" type="link"> Download Foundations of Immuno-oncology E-Book </a> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-selected-references-amp-further-reading19" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Selected References & Further Reading</h5> </a> </div> <div class="collapse" id="expPara-selected-references-amp-further-reading19" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><figure class="responsive-figure-table"><table><tbody><tr><td><p>Cruvinel ,W de M, Mesquita, D Jr, Araújo, JA, <em>et al.</em> (2010) Immune system - part I. Fundamentals of innate immunity with emphasis on molecular and cellular mechanisms of inflammatory response. <em>Rev Bras Reumatol.</em> <strong>50</strong>(4): 434-61. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/21125178/">21125178</a></p><p>Getz, GS. (2005) Thematic review series: the immune system and atherogenesis. Bridging the innate and adaptive immune systems. <em>J Lipid Res.</em> <strong>46</strong>(4): 619-22. <a href="https://www.jlr.org/article/S0022-2275(20)33995-X/fulltext">DOI: 10.1194/jlr.E500002-JLR200</a></p><p>Golubovskaya, V., & Wu, L. (2016). Different subsets of T cells, memory, effector functions, and CAR-T immunotherapy. <em>Cancers.</em> <strong>8</strong>(3): 36. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/26999211/">26999211</a></p><p>Stewart, J. (2012). Innate and acquired immunity. 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