Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions

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usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="05FnugnPXnxtwSmUYEUYFS9aS8v4og4pB5xeCncTYkdKpaJSRQMBFkJm0zCaFPtf"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="05FnugnPXnxtwSmUYEUYFS9aS8v4og4pB5xeCncTYkdKpaJSRQMBFkJm0zCaFPtf"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="05FnugnPXnxtwSmUYEUYFS9aS8v4og4pB5xeCncTYkdKpaJSRQMBFkJm0zCaFPtf"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="05FnugnPXnxtwSmUYEUYFS9aS8v4og4pB5xeCncTYkdKpaJSRQMBFkJm0zCaFPtf"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="15342556"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" href="http://genome.cshlp.org/cgi/pmidlookup?view=long&pmid=15342556" target="_blank" rel="noopener" ref="linksrc=fulltextorjournal_fulltext&is_pmc=False&PrId=3051&itool=Abstract-def&log$=linkouticon&uid=15342556&db=pubmed&nlmid=9518021" title="See full text options at HighWire" data-ga-category="full_text" data-ga-action="HighWire" data-ga-label="15342556" ><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--highwire.stanford.edu-icons-externalservices-pubmed-standard-genome_final_free.gif" alt="full text provider logo"><span class="text"> HighWire </span></a><a class="link-item pmc " href="https://pmc.ncbi.nlm.nih.gov/articles/pmid/15342556/" target="_blank" rel="noopener" ref="linksrc=fulltextorjournal_fulltext&is_pmc=True&PrId=3494&itool=Abstract-def&log$=linkouticon&uid=15342556&db=pubmed&nlmid=9518021" title="Free full text at PubMed Central" data-ga-category="full_text" data-ga-action="PMC" data-ga-label="15342556" ><span class="text"> Free PMC article </span></a> 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data-collections-open-dialog-enabled="false" data-collections-open-dialog-url="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F15342556%2F%23open-collections-dialog" data-in-collections="false"><span class="button-label">Collections</span></button><div class="overlay" role="dialog"><div id="collections-action-dialog" class="dialog collections-dialog" aria-hidden="true"><div class="title">Add to Collections</div><div class="collections-action-panel action-panel"><form id="collections-action-dialog-form" class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-existing-collections-url="/list-existing-collections/" data-add-to-existing-collection-url="/add-to-existing-collection/" data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/" data-myncbi-max-collection-name-length="100" data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="05FnugnPXnxtwSmUYEUYFS9aS8v4og4pB5xeCncTYkdKpaJSRQMBFkJm0zCaFPtf"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio" id="collections-action-dialog-new" class="collections-new" name="collections" value="new" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio" id="collections-action-dialog-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="collections_button" data-ga-action="click" data-ga-label="add"> Add </button><button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="collections_button" data-ga-action="click" data-ga-label="cancel"> Cancel </button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" 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dropdown menu for journal Genome research" data-pinger-ignore> Genome Res </button><div id="full-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal Genome research"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Genome+Res%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22Genome+Res%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=Genome Res" data-ga-category="search" data-ga-action="journal_link" data-ga-label="Genome Res"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Genome+Res%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="Genome Res"> Search in 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class="affiliation-link" title="Human Genome Center, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, 108-8639, Japan. ysuzuki@ims.u-tokyo.ac.jp" href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Yamashita+R&cauthor_id=15342556" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Riu Yamashita">Riu Yamashita</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Shirota+M&cauthor_id=15342556" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Matsuyuki Shirota">Matsuyuki Shirota</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Sakakibara+Y&cauthor_id=15342556" ref="linksrc=author_name_link" data-ga-category="search" 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href="/?term=Sugano+S&cauthor_id=15342556" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sumio Sugano">Sumio Sugano</a></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore data-fetch-url="/15342556/long-authors/" data-id-prefix=""> <span class="title"> Expand </span> </button> </div> <div class="extended-article-details" id="expanded-authors" aria-hidden="true"> <div class="expanded-authors" id="full-view-expanded-authors"> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="full-view-affiliation-1" id="full-view-affiliation-1" ><sup class="key">1</sup> Human Genome Center, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, 108-8639, Japan. ysuzuki@ims.u-tokyo.ac.jp</li> </ul> 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id="short-view-heading"> <div class="publication-type" >Comparative Study</div> <h1 class="heading-title"> Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions </h1> <div class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">Yutaka Suzuki</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> Genome Res<span class="citation-separator">.</span> </span> <span class="date"> <span class="citation-year">2004 Sep</span><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"> <button class="more-article-details" id="toggle-article-details" data-alt-text="Hide details" ref="linksrc=toggle_article_details" aria-controls="full-article-details" aria-expanded="false" data-fetch-url="/15342556/long-authors/" data-id-prefix=""> <span class="title">Show details</span> </button> <div 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data-ga-label="Yutaka Suzuki">Yutaka Suzuki</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Human Genome Center, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, 108-8639, Japan. ysuzuki@ims.u-tokyo.ac.jp" href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Yamashita+R&cauthor_id=15342556" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Riu Yamashita">Riu Yamashita</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Shirota+M&cauthor_id=15342556" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Matsuyuki Shirota">Matsuyuki Shirota</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Sakakibara+Y&cauthor_id=15342556" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Yuta Sakakibara">Yuta Sakakibara</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Chiba+J&cauthor_id=15342556" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Joe Chiba">Joe Chiba</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Mizushima-Sugano+J&cauthor_id=15342556" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Junko Mizushima-Sugano">Junko Mizushima-Sugano</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Nakai+K&cauthor_id=15342556" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Kenta Nakai">Kenta Nakai</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Sugano+S&cauthor_id=15342556" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sumio Sugano">Sumio Sugano</a></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> Human Genome Center, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, 108-8639, Japan. ysuzuki@ims.u-tokyo.ac.jp</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">15342556</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" 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data-ga-action="cite" data-ga-label="open" data-all-citations-url="/15342556/citations/" data-citation-style="nlm" data-pubmed-format-link="/15342556/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> Comparative sequence analysis was carried out for the regions adjacent to experimentally validated transcriptional start sites (TSSs), using 3324 pairs of human and mouse genes. We aligned the upstream putative promoter sequences over the 1-kb proximal regions and found that the sequence conservation could not be further extended at, on average, 510 bp upstream positions of the TSSs. This discontinuous manner of the sequence conservation revealed a "block" structure in about one-third of the putative promoter regions. Consistently, we also observed that G+C content and CpG frequency were significantly different inside and outside the blocks. Within the blocks, the sequence identity was uniformly 65% regardless of their length. About 90% of the previously characterized transcription factor binding sites were located within those blocks. In 46% of the blocks, the 5' ends were bounded by interspersed repetitive elements, some of which may have nucleated the genomic rearrangements. The length of the blocks was shortest in the promoters of genes encoding transcription factors and of genes whose expression patterns are brain specific, which suggests that the evolutional diversifications in the transcriptional modulations should be the most marked in these populations of genes. </p> </div> </div> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" ga_category="literature_resources" ga_action="disclaimer_link" ga_label="under_abstract">PubMed Disclaimer</a> </p> <div class="figures" id="figures"> <h2 class="title"> Figures </h2> <div class="figures-list" id="slides-container" itemscope itemtype="http://schema.org/ImageGallery"> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="0" data-label-slug="figure-1"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9df8/515316/ed76dba84858/82626-10f1_1o.jpg" itemprop="contentUrl" aria-describedby="figure-caption-0" role="button" data-image-width="512" data-image-height="266" data-image-alt="Figure 1" data-pmc-id="PMC515316" data-figure-id="fig1"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-0" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9df8/515316/2aa3021e8f55/82626-10f1_1o.gif" alt="Figure 1" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="512"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="266"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 1 </p> </strong> <div class="figure-caption-contents"><p> Sequence identity between human and… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 1 </p> </strong> <div class="figure-caption-contents"><p> Sequence identity between human and mouse PPRs. Sequence alignments were calculated using LALIGN… </p></div> </div> <figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 1 </strong> <div class="figure-caption-contents">Sequence identity between human and mouse PPRs. Sequence alignments were calculated using LALIGN with the default parameters. The sequence identity was evaluated as the number of aligned nucleotides in the regions of -1000 to +200 (TSS: 0). The average sequence identities were calculated for each region (<i>A</i>). (<i>B</i>) The PPRs were separated into the 200-bp windows at the positions indicated in the <i>inset</i>. Sequence identity was calculated for each of the windows. Frequency as to which of the windows belong to which of the sequence identity groups represented on the horizontal axis is plotted.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="1" data-label-slug="figure-2"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9df8/515316/2baf0e31e709/82626-10f2_1o.jpg" itemprop="contentUrl" aria-describedby="figure-caption-1" role="button" data-image-width="512" data-image-height="352" data-image-alt="Figure 2" data-pmc-id="PMC515316" data-figure-id="fig2"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-1" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9df8/515316/10ea582360c6/82626-10f2_1o.gif" alt="Figure 2" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="512"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="352"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 2 </p> </strong> <div class="figure-caption-contents"><p> Sequence alignments of the block… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 2 </p> </strong> <div class="figure-caption-contents"><p> Sequence alignments of the block structure in PPRs and nongenic regions. ( <i> A… </i> </p></div> </div> <figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 2 </strong> <div class="figure-caption-contents">Sequence alignments of the block structure in PPRs and nongenic regions. (<i>A</i>) Frequency of the blocks belonging to each population is shown. (<i>B</i>) Relation between length of the block and the average sequence identity within it. (<i>C</i>) Relation between percentile position within the block and the average sequence identity. (<i>D</i>) Alignment of the nongenic sequences using LALIGN. The sequences ranging from -1 kb to + 200 bp of the putative syntenic regions located in nongenic regions as in UCSC genome browser were aligned and the frequencies of the aligned nucleotides were calculated at each of the positions. Vertical line represents the frequency of the nucleotide at the indicated position being located within the block. (Note that the vertical axis in Figure 1 represents the frequency of the sequence “identity”).</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="2" data-label-slug="figure-3"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9df8/515316/724b4cb13887/82626-10f3_1o.jpg" itemprop="contentUrl" aria-describedby="figure-caption-2" role="button" data-image-width="512" data-image-height="184" data-image-alt="Figure 3" data-pmc-id="PMC515316" data-figure-id="fig3"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-2" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9df8/515316/3f87bcdf3320/82626-10f3_1o.gif" alt="Figure 3" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="512"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="184"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 3 </p> </strong> <div class="figure-caption-contents"><p> Sequence alignments around the boundary… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 3 </p> </strong> <div class="figure-caption-contents"><p> Sequence alignments around the boundary of the block and that of the first… </p></div> </div> <figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 3 </strong> <div class="figure-caption-contents">Sequence alignments around the boundary of the block and that of the first intron and the second exon using SSEARCH. (<i>A</i>) Sequences of human and mouse PPRs were aligned using SSEARCH with a 50-bp moving window around the boundary of the block. The broken line represents the boundary of the block calculated using LALIGN. The vertical axis represents the average score of the SSEARCH calculated for the corresponding position. The horizontal axis represents the relative position to the boundary. (<i>B</i>) Result of an analysis similar to that shown in <i>A</i>, using the proximal sequences of the 5′ end of the second exons. The broken line represents the exon-intron boundary. The horizontal axis represents the relative position to the exon-intron boundary.</div> </figcaption> </figure> </div>  <div class="pswp figures-dialog" id="figures-dialog" tabindex="-1" role="dialog" aria-hidden="true" data-image-gallery-uid="article-figures" aria-label="Figures Dialog">  <div class="pswp__bg"></div>  <div class="pswp__scroll-wrap">  <div class="pswp__container"> <div class="pswp__item"></div> <div class="pswp__item"></div> <div class="pswp__item"></div> </div>  <div class="pswp__ui pswp__ui--hidden"> <div class="pswp__top-bar">  <div class="pswp__counter"></div> <button class="pswp__button pswp__button--close" title="Close (Esc)"></button> <button class="pswp__button pswp__button--share" title="Share"></button> <button class="pswp__button pswp__button--fs" title="Toggle fullscreen"></button> <button class="pswp__button pswp__button--zoom" title="Zoom in/out"></button>   <div class="pswp__preloader"> <div class="pswp__preloader__icn"> <div class="pswp__preloader__cut"> <div class="pswp__preloader__donut"></div> </div> </div> </div> </div> <div class="pswp__share-modal pswp__share-modal--hidden pswp__single-tap"> <div class="pswp__share-tooltip"></div> </div> <button class="pswp__button pswp__button--arrow--left" title="Previous (arrow left)"> </button> <button class="pswp__button pswp__button--arrow--right" title="Next (arrow right)"> </button> <div class="pswp__caption"> <div class="pswp__caption__center"></div> </div> </div> </div> </div> <div class="figure-dialog-caption"> <div class="figure-caption-link-container"> <a class="figure-caption-link" href="#">See this image and copyright information in PMC</a> </div> <div class="figure-caption-center" data-expand-title="click to show full caption" data-collapse-title="click to hide full caption"> </div> <button class="figure-caption-toggle-btn" aria-label="show full caption" data-expand-text="show full caption" data-collapse-text="hide full caption">  </button> </div> </div> <div class="similar-articles" id="similar"> <h2 class="title"> Similar articles </h2> <ul class="articles-list" id="similar-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/15506993/" ref="article_id=15506993&linksrc=similar_articles_link&ordinalpos=1" data-ga-category="similar_article" data-ga-action="15506993" data-ga-label=""> Large-scale collection and characterization of promoters of human and mouse genes. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Kel AE, Arakawa T, Carninci P, Kawai J, Hayashizaki Y, Takagi T, Nakai K, Sugano S.</span> <span class="docsum-authors short-authors">Suzuki Y, et al.</span> <span class="docsum-journal-citation full-journal-citation">In Silico Biol. 2004;4(4):429-44.</span> <span class="docsum-journal-citation short-journal-citation">In Silico Biol. 2004.</span> <span class="citation-part">PMID: <span class="docsum-pmid">15506993</span></span> </div> </div> </li> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/7478607/" ref="article_id=7478607&linksrc=similar_articles_link&ordinalpos=2" data-ga-category="similar_article" data-ga-action="7478607" data-ga-label=""> Identification and functional characterization of the human and murine polo-like kinase (Plk) promoter. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Bräuninger A, Strebhardt K, Rübsamen-Waigmann H.</span> <span class="docsum-authors short-authors">Bräuninger A, et al.</span> <span class="docsum-journal-citation full-journal-citation">Oncogene. 1995 Nov 2;11(9):1793-800.</span> <span class="docsum-journal-citation short-journal-citation">Oncogene. 1995.</span> <span class="citation-part">PMID: <span class="docsum-pmid">7478607</span></span> </div> </div> </li> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/16181749/" ref="article_id=16181749&linksrc=similar_articles_link&ordinalpos=3" data-ga-category="similar_article" data-ga-action="16181749" data-ga-label=""> Transcriptional regulation of the mouse PNRC2 promoter by the nuclear factor Y (NFY) and E2F1. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Zhou D, Masri S, Ye JJ, Chen S.</span> <span class="docsum-authors short-authors">Zhou D, et al.</span> <span class="docsum-journal-citation full-journal-citation">Gene. 2005 Nov 21;361:89-100. doi: 10.1016/j.gene.2005.07.012. 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href="https://www.ncbi.nlm.nih.gov/mesh?term=Animals" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Animals"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Animals"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Animals"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Binding Sites" tabindex="0" aria-controls="keyword-actions-mesh-terms-1" aria-expanded="false" data-pinger-ignore> Binding Sites </button><div id="keyword-actions-mesh-terms-1" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Binding Sites"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Binding+Sites%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Binding+Sites%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Binding Sites"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Binding Sites"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Binding+Sites" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Binding Sites"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Binding Sites"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Binding Sites"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Biological Evolution*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-2" aria-expanded="false" data-pinger-ignore> Biological Evolution* </button><div id="keyword-actions-mesh-terms-major-2" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Biological Evolution*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Biological+Evolution%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Biological+Evolution%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Biological Evolution"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Biological Evolution*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Biological+Evolution" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Biological Evolution*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Biological Evolution"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Biological Evolution"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Brain / metabolism*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-3" aria-expanded="false" data-pinger-ignore> Brain / metabolism* </button><div id="keyword-actions-mesh-terms-major-3" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Brain / metabolism*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Brain%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Brain%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Brain/metabolism"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Brain / metabolism*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Brain" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Brain / metabolism*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Brain/metabolism"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Brain/metabolism"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Conserved Sequence" tabindex="0" aria-controls="keyword-actions-mesh-terms-4" aria-expanded="false" data-pinger-ignore> Conserved Sequence </button><div id="keyword-actions-mesh-terms-4" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Conserved Sequence"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Conserved+Sequence%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Conserved+Sequence%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Conserved Sequence"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Conserved Sequence"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Conserved+Sequence" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Conserved Sequence"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Conserved Sequence"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Conserved Sequence"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Genes" tabindex="0" aria-controls="keyword-actions-mesh-terms-5" aria-expanded="false" data-pinger-ignore> Genes </button><div id="keyword-actions-mesh-terms-5" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Genes"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Genes%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Genes%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Genes"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Genes"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Genes" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Genes"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Genes"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Genes"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Humans" tabindex="0" aria-controls="keyword-actions-mesh-terms-6" aria-expanded="false" data-pinger-ignore> Humans </button><div id="keyword-actions-mesh-terms-6" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Humans"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Humans"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Humans"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Humans" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Humans"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Humans"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Humans"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Mice" tabindex="0" aria-controls="keyword-actions-mesh-terms-7" aria-expanded="false" data-pinger-ignore> Mice </button><div id="keyword-actions-mesh-terms-7" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Mice"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Mice%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Mice%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Mice"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Mice"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Mice" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Mice"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Mice"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Mice"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Molecular Sequence Data" tabindex="0" aria-controls="keyword-actions-mesh-terms-8" aria-expanded="false" data-pinger-ignore> Molecular Sequence Data </button><div id="keyword-actions-mesh-terms-8" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Molecular Sequence Data"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Molecular+Sequence+Data%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Molecular+Sequence+Data%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Molecular Sequence Data"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Molecular Sequence Data"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Molecular+Sequence+Data" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Molecular Sequence Data"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Molecular Sequence Data"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Molecular Sequence Data"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Promoter Regions, Genetic*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-9" aria-expanded="false" data-pinger-ignore> Promoter Regions, Genetic* </button><div id="keyword-actions-mesh-terms-major-9" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Promoter Regions, Genetic*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Promoter+Regions%2C+Genetic%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Promoter+Regions%2C+Genetic%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Promoter Regions, Genetic"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Promoter Regions, Genetic*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Promoter+Regions%2C+Genetic" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Promoter Regions, Genetic*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Promoter Regions, Genetic"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Promoter Regions, Genetic"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Repetitive Sequences, Nucleic Acid*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-10" aria-expanded="false" data-pinger-ignore> Repetitive Sequences, Nucleic Acid* </button><div id="keyword-actions-mesh-terms-major-10" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Repetitive Sequences, Nucleic Acid*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Repetitive+Sequences%2C+Nucleic+Acid%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Repetitive+Sequences%2C+Nucleic+Acid%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Repetitive Sequences, Nucleic Acid"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Repetitive Sequences, Nucleic Acid*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Repetitive+Sequences%2C+Nucleic+Acid" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Repetitive Sequences, Nucleic Acid*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Repetitive Sequences, Nucleic Acid"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Repetitive Sequences, Nucleic Acid"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Tissue Distribution" tabindex="0" aria-controls="keyword-actions-mesh-terms-11" aria-expanded="false" data-pinger-ignore> Tissue Distribution </button><div id="keyword-actions-mesh-terms-11" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Tissue Distribution"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Tissue+Distribution%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Tissue+Distribution%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Tissue Distribution"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Tissue Distribution"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Tissue+Distribution" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Tissue Distribution"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Tissue Distribution"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Tissue Distribution"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Transcription Factors / metabolism*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-12" aria-expanded="false" data-pinger-ignore> Transcription Factors / metabolism* </button><div id="keyword-actions-mesh-terms-major-12" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Transcription Factors / metabolism*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Transcription+Factors%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Transcription+Factors%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Transcription Factors/metabolism"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Transcription Factors / metabolism*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Transcription+Factors" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Transcription Factors / metabolism*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Transcription Factors/metabolism"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Transcription Factors/metabolism"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Transcription, Genetic*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-13" aria-expanded="false" data-pinger-ignore> Transcription, Genetic* </button><div id="keyword-actions-mesh-terms-major-13" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Transcription, Genetic*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Transcription%2C+Genetic%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Transcription%2C+Genetic%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Transcription, Genetic"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Transcription, Genetic*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Transcription%2C+Genetic" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Transcription, Genetic*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Transcription, Genetic"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Transcription, Genetic"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="substances" class="substances keywords-section"> <h2 class="title"> Substances </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Transcription Factors" tabindex="0" aria-controls="keyword-actions-substances-0" aria-expanded="false" data-pinger-ignore> Transcription Factors </button><div id="keyword-actions-substances-0" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Transcription Factors"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Transcription+Factors%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Transcription+Factors%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Transcription Factors"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Transcription Factors"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Transcription+Factors%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Transcription Factors"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Transcription Factors"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Transcription Factors"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="supplemental-data" class="supplemental-data"> <h2 class="title"> Associated data </h2> <ul class="supplemental-data-list"><li><div class="supplemental-data-actions dropdown-block"><button class="supplemental-data-actions-trigger trigger" title="Supplemental Data Dropdown Toggle" ref="linksrc=supplemental_data_actions_btn" tabindex="0" aria-controls="supplemental-data-GENBANK-BP192706" aria-describedby="supplemental-data-GENBANK-BP192706" data-pinger-ignore> GENBANK/BP192706 </button><div id="supplemental-data-GENBANK-BP192706" class="supplemental-data-actions-dropdown dropdown dropdown-container" hidden aria-label="GENBANK/BP192706"><div class="title">Actions</div><div class="content"><ul class="supplemental-data-actions-links"><li><a class="dropdown-block-link" title="Search in PubMed" href="/?term=BP192706%5BSecondary+Source+ID%5D" ref="linksrc=ssid_link" data-ga-category="search" data-ga-action="data" data-ga-label="BP192706[Secondary Source ID]"> Search in PubMed </a></li><li><a class="dropdown-block-link" title="Search in Nucleotide" href="https://www.ncbi.nlm.nih.gov/nucleotide?term=BP192706" ref="linksrc=ssid_link" data-ga-category="search" data-ga-action="data" data-ga-label="None"> Search in Nucleotide </a></li></ul></div></div></div></li><li><div 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aria-describedby="supplemental-data-GENBANK-BP192718" data-pinger-ignore> GENBANK/BP192718 </button><div id="supplemental-data-GENBANK-BP192718" class="supplemental-data-actions-dropdown dropdown dropdown-container" hidden aria-label="GENBANK/BP192718"><div class="title">Actions</div><div class="content"><ul class="supplemental-data-actions-links"><li><a class="dropdown-block-link" title="Search in PubMed" href="/?term=BP192718%5BSecondary+Source+ID%5D" ref="linksrc=ssid_link" data-ga-category="search" data-ga-action="data" data-ga-label="BP192718[Secondary Source ID]"> Search in PubMed </a></li><li><a class="dropdown-block-link" title="Search in Nucleotide" href="https://www.ncbi.nlm.nih.gov/nucleotide?term=BP192718" ref="linksrc=ssid_link" data-ga-category="search" data-ga-action="data" data-ga-label="None"> Search in Nucleotide </a></li></ul></div></div></div></li><li><div class="supplemental-data-actions dropdown-block"><button class="supplemental-data-actions-trigger trigger" 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Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions - PubMed