CSHLPress.com - nuclear pores cell cancer

<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd"> <html xmlns="http://www.w3.org/1999/xhtml">  <head> <meta http-equiv="Content-Type" content="text/html; charset=ISO-8859-1" /> <title>CSHLPress.com - nuclear pores cell cancer </title> <link rel="stylesheet" href="css/nsnew_csh.css" type="text/css" media="all"> <link rel="stylesheet" href="css/csh_smsi.css" type="text/css" media="all"> <script type="text/javascript" src="js/csh.js"></script> <link rel="stylesheet" href="css/nsnew_search.css" type="text/css" media="all"> <script type='text/javascript' src='js/ns_search1.js'></script> <script type='text/javascript' src='js/ns_search.js'></script> <link rel="stylesheet" href="css/style14.css" type="text/css" media="all"> <meta name="viewport" content="width=device-width"> <style> .post { margin:0 0 1.2em; border-bottom:1px dotted #ccc; padding-bottom:.7em; } </style> </head> <body> <header id=main-navigation> <a id=cshl-home-page href="https://www.cshl.edu/"><img id="cshl-logo" src="/images/cshllogo_ko.svg" alt="CSHL Logo"></a> <a href="default.tpl?cart=1733169139210564329">Cold Spring Harbor Laboratory Press Bookstore</a> <span>A Division of CSHL</span> <div class=right> <a href="https://www.cshl.edu/education/">Education Programs</a> <a href="https://www.cshl.edu/research/faculty-staff/">Faculty</a> </div> </header> <div id ="container"> <div id ="mast"> <table border="0" cellspacing="0" cellpadding="0"> <tr> <td valign="top"> <a href="default.tpl?cart=1733169139210564329"><img src="images/cshlptopbanner.jpg" border="0" ></a> </td> </tr> </table> </div>  <div id="navContainer14"> <ul id="menutop"> <li class="width600"><a href="#" class="dropnone">Subject Categories</a></li> <li><a href="default.tpl?cart=1733169139210564329" class="dropnone">Home</a> </li> <li class="width600"><a href="#" class="drop">Books</a> <div class="dropdown_1column"> <div class="col_1"> <ul class="simple"> <li><a href=default.tpl?cart=1733169139210564329&id1=1&startat=1&--woSECTIONSdatarq=1&--SECTIONSword=ww&sortby_1=title">Browse all</a></li> <li><a href="default.tpl?cart=1733169139210564329&id1=144&startat=1&--woSECTIONSdatarq=144&--SECTIONSword=ww&sortby_1=recency">Handbooks</a></li> <li><a href="default.tpl?id1=29&cart=1733169139210564329&startat=1&--woSECTIONSdatarq=29&--SECTIONSword=ww&sortby_1=recency">Childrens books</a></li> <li><a href="listshow_monthly.tpl?cart=1733169139210564329">Books on Sale</a></li> <li><a href="permission_form.tpl?cart=1733169139210564329">Rights and Permissions</a></li> <li><a href="contactus.tpl?cart=1733169139210564329">Submit a Book Proposal</a></li> <li><a href="faqform/CSHExamCopy.pdf" target=_blank>Request an Exam Copy</a></li> <li><a href="ebook_howto.tpl?cart=1733169139210564329">eBook FAQ</a></li> </ul> </div> </div> </li> <li class="width600"><a href="#" class="drop">Journals</a> <div class="dropdown_1column"> <div class="col_1"> <ul class="simple"> <li><a href="http://genesdev.org" target="_blank">Genes & Development</a></li> <li><a href="https://genome.org" target="_blank">Genome Research</a></li> <li><a href="http://learnmem.org" target="_blank">Learning & Memory</a></li> <li><a href="http://www.life-science-alliance.org/" target="_blank">Life Science Alliance</a></li> <li><a href="http://molecularcasestudies.org" target="_blank">Molecular Case Studies</a></li> <li><a href="http://cshperspectives.org" target="_blank">Perspectives in Biology</a></li> <li><a href="http://perspectivesinmedicine.org" target="_blank">Perspectives in Medicine</a></li> <li><a href="http://cshprotocols.org" target="_blank">Protocols</a></li> <li><a href="http://rnajournal.org" target="_blank">RNA</a></li> <li><a href="permission_form.tpl">Rights and Permissions</a></li> </ul> </div> </div> </li> <li class="width600"><a href="#" class="drop">Sale</a> <div class="dropdown_1column"> <div class="col_1"> <ul class="simple"> <li><a href="monthlysale.tpl?cart=1733169139210564329">Special Offers</a></li> <li><a href="listshow.tpl?cart=1733169139210564329">Classic Titles on Sale</a></li> </ul> </div> </div> </li> <li class="width600"><a href="page_search.tpl?cart=1733169139210564329" class="drop">Search</a> <div class="dropdown_5columns"> <div id="searcher" style="padding-left:4px;padding-bottom:8px;padding-top:10px;"> <table cellspacing="0" cellpadding="0" width=900 border=0> <tr><td colspan=6 style="padding-left:3px;padding-right:3px;"><table cellspacing="0" cellpadding="0" width=100%> <tr><td width="85%" style="font-size:110%;color:black;"><b>Search</b>  (type two or more letters for suggestions):</td> </td><td width=15% align="right"><a href="page_search.tpl?cart=1733169139210564329" >Or: Advanced Search</a></td></tr> </table></td></tr> <tr><td style="padding-left:3px;"><form style="padding-top:2px;padding-bottom:6px;margin-bottom:0px;" action="page_search.tpl?cart=1733169139210564329" method="get" name="searcher"> <input type="hidden" name="cart" value="1733169139210564329"> <input type="hidden" name="startat" value="1"> <input value="Enter title" onclick="this.value='';this.style.color='#000000';" title="title" type="text" size="30" name="--woGROUP1datarq" id="q0" autocomplete="off" onkeyup="loadXMLDoc('seekertitle.tpl?cart=1733169139210564329&arg='+this.value,this.value)" style="color:#666666;font-size:16px;height:22px;width:320px;" /> </form> </td><td align="center"> <form style="padding-top:2px;padding-bottom:6px;margin-bottom:0px;"action="page_search.tpl?cart=1733169139210564329" method="get" name="searcher" >   <input value="or author" onclick="this.value='';this.style.color='#000000';" title="title" type="text" size="30" name="--woGROUP1datarq" id="q0" autocomplete="off" onkeyup="loadXMLDoc('seeker.tpl?cart=1733169139210564329&arg='+this.value,this.value)" style="color:#666666;font-size:16px;height:22px;width:320px;" /> <input type="hidden" name="cart" value="1733169139210564329"> </form> </td> <td style="padding-right:3px;" align="right"> <form style="padding-top:2px;padding-bottom:6px;margin-bottom:0px;"action="page_search.tpl?cart=1733169139210564329" method="get" name="searcher" >   <input value="or ISBN" onclick="this.value='';this.style.color='#000000';" title="title" type="text" size="30" name="--woGROUP1datarq" id="q0" autocomplete="off" onkeyup="loadXMLDoc('seekerisbn.tpl?cart=1733169139210564329&arg='+this.value,this.value)" style="color:#666666;font-size:16px;height:22px;width:150px;" /> <input type="hidden" name="cart" value="1733169139210564329"> </form> </td> </tr> </table><div align="left" id="searchResult0" class="ddbox" name="--woGROUP1datarq" style="font-family:Arial; line-height:15px; font-size:12px; width:680px; height:140px; border:#000000 solid 1px; padding:3px; visibility:hidden; position:absolute; left: 78px; z-index:1000; overflow: auto; "></div> <input type="hidden" name="cart" value="1733169139210564329"> </form> </div> </div> </li> <li><a href="login.tpl?cart=1733169139210564329" class="dropnone">Sign In</a></li>  <li class="menu_right"><a href="/checkout.tpl?cart=1733169139210564329" class="dropnone">Checkout/View Cart</a></li> </ul> </div> <div id="main-container"> <div id="leftColumn"> <ul class="scnav" > <li><a href="/default.tpl?cart=1733169139210564329&id1=138&startat=1&--woSECTIONSdatarq=138&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Aging Research</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=135&startat=1&--woSECTIONSdatarq=135&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Autobiography/Biography</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=91&startat=1&--woSECTIONSdatarq=91&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Bacteria</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=109&startat=1&--woSECTIONSdatarq=109&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Biochemistry</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=134&startat=1&--woSECTIONSdatarq=134&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Bioinformatics</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=96&startat=1&--woSECTIONSdatarq=96&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Biology in Society</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=92&startat=1&--woSECTIONSdatarq=92&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Biophysics</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=110&startat=1&--woSECTIONSdatarq=110&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Biotechnology</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=93&startat=1&--woSECTIONSdatarq=93&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Caenorhabditis elegans</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=23&startat=1&--woSECTIONSdatarq=23&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Cancer Biology</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=140&startat=1&--woSECTIONSdatarq=140&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Career Development</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=24&startat=1&--woSECTIONSdatarq=24&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Cell Biology</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=29&startat=1&--woSECTIONSdatarq=29&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Children's Books</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=141&startat=1&--woSECTIONSdatarq=141&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Cognition and Behavior</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=142&startat=1&--woSECTIONSdatarq=142&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Cold Spring Harbor Laboratory History</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=89&startat=1&--woSECTIONSdatarq=89&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Developmental Biology</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=94&startat=1&--woSECTIONSdatarq=94&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Drosophila melanogaster</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=98&startat=1&--woSECTIONSdatarq=98&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Gene Therapy</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=28&startat=1&--woSECTIONSdatarq=28&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> General Interest Titles</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=90&startat=1&--woSECTIONSdatarq=90&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Genetics</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=143&startat=1&--woSECTIONSdatarq=143&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Genomics</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=144&startat=1&--woSECTIONSdatarq=144&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Handbooks</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=99&startat=1&--woSECTIONSdatarq=99&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> History of Science</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=100&startat=1&--woSECTIONSdatarq=100&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Human Biology and Disease</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=25&startat=1&--woSECTIONSdatarq=25&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Immunology and Vaccines</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=20&startat=1&--woSECTIONSdatarq=20&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Laboratory Techniques</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=101&startat=1&--woSECTIONSdatarq=101&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Microbiology</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=102&startat=1&--woSECTIONSdatarq=102&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Microscopy and Imaging</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=21&startat=1&--woSECTIONSdatarq=21&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Molecular Biology</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=103&startat=1&--woSECTIONSdatarq=103&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Mouse Biology</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=145&startat=1&--woSECTIONSdatarq=145&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Multimedia</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=26&startat=1&--woSECTIONSdatarq=26&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Neurobiology</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=97&startat=1&--woSECTIONSdatarq=97&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Origin and Evolution of Life</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=22&startat=1&--woSECTIONSdatarq=22&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Plant Biology</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=105&startat=1&--woSECTIONSdatarq=105&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Proteins and Proteomics</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=146&startat=1&--woSECTIONSdatarq=146&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Statistics</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=88&startat=1&--woSECTIONSdatarq=88&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Viruses</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=107&startat=1&--woSECTIONSdatarq=107&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Xenopus laevis</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=108&startat=1&--woSECTIONSdatarq=108&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Yeast</a> </li> <li><a href="/default.tpl?cart=1733169139210564329&id1=147&startat=1&--woSECTIONSdatarq=147&--SECTIONSword=ww&sortby_1=recency"><span class="arrow">▶</span> Zoology</a> </li> </ul> </div> <div id="mainColumnSub"> <table border="0" cellpadding="0" cellspacing="0" height="698px"> <tr> <td valign="top"> <TABLE bgcolor="white" border=0 cellpadding=5 cellspacing=0> <tr><td valign="top"><h2>CSHL Press News </h2> </td></tr> <tr><td valign="top"> <b>Tweaking cells’ gatekeepers could lead to new way to fight cancer</b></a><BR><BR> 09/18/2018<BR> <time class="noprint">September 18, 2018</time> <h2>Tweaking cells’ gatekeepers could lead to new way to fight cancer</h2> <p><strong>Salk scientists develop method to manipulate numbers of nuclear pores</strong></p> <time class="printonly">September 18, 2018</time> <p>LA JOLLA—If the cell nucleus is like a bank for DNA, nuclear pores are the security doors around its perimeter. Yet more security doors aren’t necessarily better: some cancer cells contain a dramatic excess of nuclear pores.</p> <figure id="attachment_19757" class="wp-caption alignright"><a href="https://www.salk.edu/wp-content/uploads/2018/09/McCloskey-Hetzer-2-1.jpg"><img class="img-responsive wp-image-19757 size-pr-300" src="https://www.salk.edu/wp-content/uploads/2018/09/McCloskey-Hetzer-2-1-300x298.jpg" alt="Tweaking cells’ gatekeepers could lead to new way to fight cancer. " 512w" sizes="(max-width: 300px) 100vw, 300px"></a><figcaption class="wp-caption-text">Tweaking cells’ gatekeepers could lead to new way to fight cancer. <p></p> <p><a href="https://www.salk.edu/wp-content/uploads/2018/09/McCloskey-Hetzer-2-1.jpg">Click here</a> for a high-resolution image.</p> <p>Credit: Salk Institute</p></figcaption></figure> <p>Salk Institute researchers reported on September 18, 2018, in the journal <a href="http://genesdev.cshlp.org/content/early/2018/09/18/gad.315523.118" target="_blank" rel="noopener"><em>Genes & Development</em></a> that they have devised a way to manipulate numbers of individual nuclear pores—a breakthrough that may one day stop cancerous cells from proliferating out of control.</p> <p>“Previously, we didn’t have the tools to artificially increase nuclear pores,” says lead author <a href="https://www.salk.edu/scientist/martin-hetzer/">Martin Hetzer</a>, who is also Salk’s vice president and chief science officer. “Our study provides an experimental avenue to ask critical questions: What are the consequences of boosting the number of nuclear pores in a healthy cell to mimic those found in a cancer cell? Does this affect gene activity? Why do cancer cells increase the number of nuclear pores?”</p> <p>Nuclear pores are essential elements of all cells that provide controlled ways to move cellular material in and out of a nucleus. In organisms ranging from fungi to mammals, individual cells possess these transport channels that mediate a thousand events per second. Individual nuclear pores are fashioned from multiple copies of 30 proteins known as nucleoporins. Hetzer and colleagues looked at the nucleoporin Tpr, which has been implicated in certain cancers.</p> <p>The team showed, for the first time, that each of the transport channels within a cell is unique, and each cell nucleus possesses a specific number of nuclear pores. Next, the team used molecular methods to remove Tpr to see its effect on the number of nuclear pores, with a surprising result.</p> <figure id="attachment_19756" class="wp-caption alignleft"><img class="img-responsive wp-image-19756 size-pr-300" src="https://www.salk.edu/wp-content/uploads/2018/09/Fig_McCloskey_Hetzer-hr-1-300x245.jpg" alt="Cells with the Tpr protein (top row) have fewer nuclear pores than cells without the protein (bottom row). The right column shows a close-up of the pore density, with many more pores appearing in the absence of Tpr (bottom left). " srcset="https://www.salk.edu/wp-content/uploads/2018/09/Fig_McCloskey_Hetzer-hr-1-300x245.jpg 300w,977w" sizes="(max-width: 300px) 100vw, 300px"><figcaption class="wp-caption-text">Cells with the Tpr protein (top row) have fewer nuclear pores than cells without the protein (bottom row). The right column shows a close-up of the pore density, with many more pores appearing in the absence of Tpr (bottom left). <p></p> <p><a href="https://www.salk.edu/wp-content/uploads/2018/09/Fig_McCloskey_Hetzer-hr-1.jpg">Click here</a> for a high-resolution image.</p> <p>Credit: Salk Institute</p></figcaption></figure> <p>“Typically, when you ‘knock down’ or remove some of the proteins that make up the nuclear pore complex, the total number of nuclear pores goes down,” says Asako McCloskey, first author of the paper and a Salk research associate. “Our surprising finding was that when we get rid of the nucleoporin Tpr, nuclear pore numbers went up dramatically.”</p> <p>“This is the first time that modifying a component within the transport channel has been shown to increase the number of nuclear pores,” adds Hetzer.</p> <p>This indicates that Tpr plays a role not in transport itself, but in regulating the assembly of nuclear pores. The knowledge could be crucial for future attempts to manipulate numbers of nuclear pores to treat disease. For example, cells with higher metabolic activity—such as stimulated thyroid follicular cells or aggressive tumors—have more nuclear pores per nucleus. Other research has shown that stopping cancer-related “cargo” proteins from being transported through the nuclear pores can lead to dramatic effects in cancer treatment. Targeting nuclear pores could also negate aggressive cancer’s resistance to multiple drugs, as higher numbers of nuclear pores in tumor cells allow them to export chemotherapy out of the nuclei.</p> <p>Next, the lab will use the new technique to pinpoint the effects of tweaking nuclear pore numbers in a variety of cell types.</p> <p>The paper’s other author is Arkaitz Ibarra, a scientist at Molecular Stethoscope in San Diego.</p> <p>The work was funded by the National Institutes of Health, the Helmsley Center for Genomic Medicine, the Nomis Foundation and the Glenn Center for Aging Research.</p> </div> </div> </div> </section> <section class="publication-information"> <div class="container"> <div class="row"> <div class="col-sm-12 col-md-10 col-md-offset-1"> <h5 class="category">PUBLICATION INFORMATION</h5> <hr> <div><p><strong>JOURNAL</strong></p><p class="-serif"><em>Genes & Development</em></p></div> <div><p><strong>TITLE</strong></p><p class="-serif"> <a class="underline" href="http://genesdev.cshlp.org/content/early/2018/09/18/gad.315523.118" target="_blank"> Tpr regulates the total number of nuclear pore complexes per cell nucleus </a> </p></div> <div><p><strong>AUTHORS</strong></p><p class="-serif">Martin Hetzer, Asako McCloskey and Arkaitz Ibarra</p><BR><BR> </td></tr> <tr><td valign="top"><a href="press.tpl">Return to CSHL Press News index</a></td></tr> </table></td></tr></table> </div> </div> </div>  <footer id="site-footer"> <div id="bookstore-footer"> <div class="row"> <h2><a href="default.tpl?cart=1733169139210564329">Cold Spring Harbor Laboratory Press Bookstore</a></h2> </div> <div class="row"> <div class="column"> <h4>About</h4> <a href="contactus.tpl?cart=1733169139210564329">About Us</a><br> <a href="events.tpl?cart=1733169139210564329">Community Highlights</a><br> <a href="faq1.tpl?cart=1733169139210564329">FAQ</a><br> <a href="/cdn-cgi/l/email-protection#5330203b23213620201330203b3f7d3637266c202631393630276e10001b1f76616303213620207661631536363731323038">Feedback</a><br> <a href="press.tpl?cart=1733169139210564329">News</a><br> <a href="privacy_policy.tpl?cart=1733169139210564329">Privacy Policy</a><br> <a href="permission_form.tpl?cart=1733169139210564329">Rights and Permissions</a><br> <a href="sitemap.tpl?cart=1733169139210564329">Sitemap</a><br> <a href="intldist.tpl?cart=1733169139210564329">Worldwide Offices</a><br> </div> <div class="column"> <h4>Books</h4> <a href="page_search.tpl?cart=1733169139210564329">Advance Search</a><br> <a href="default.tpl?cart=1733169139210564329&id1=1&startat=1&--woSECTIONSdatarq=1&--SECTIONSword=ww&sortby_1=title%22">Browse All</a><br> <a href="default.tpl?cart=1733169139210564329&id1=29&startat=1&--woSECTIONSdatarq=29&--SECTIONSword=ww&sortby_1=recency">Children's Books</a><br> <a href="ebook_howto.tpl?cart=1733169139210564329">eBook FAQ</a><br> <a href="default.tpl?cart=1733169139210564329&id1=144&startat=1&--woSECTIONSdatarq=144&--SECTIONSword=ww&sortby_1=recency">Handbooks</a><br> <a href="faqform/CSHExamCopy.pdf" target="_blank">Request Exam Copy</a><br> </div> <div class="column"> <h4>Journals</h4> <a href="http://genesdev.org/" target="_blank">Genes & Development <span class="fas fa-external-link-alt"></span></a><br>  <a href="https://genome.org/" target="_blank">Genome Research <span class="fas fa-external-link-alt"></span></a><br> <a href="http://learnmem.org/" target="_blank">Learning & Memory <span class="fas fa-external-link-alt"></span></a><br> <a href="http://www.life-science-alliance.org/" target="_blank">Life Science Alliance <span class="fas fa-external-link-alt"></span></a><br> <a href="http://molecularcasestudies.org/" target="_blank">Molecular Case Studies <span class="fas fa-external-link-alt"></span></a><br> <a href="http://cshperspectives.org/" target="_blank">Perspectives in Biology <span class="fas fa-external-link-alt"></span></a><br> <a href="http://perspectivesinmedicine.org/" target="_blank">Perspectives in Medicine <span class="fas fa-external-link-alt"></span></a><br> <a href="http://cshprotocols.org/" target="_blank">Protocols <span class="fas fa-external-link-alt"></span></a><br> <a href="http://rnajournal.org/" target="_blank">RNA <span class="fas fa-external-link-alt"></span></a><br> </div> <div class="column"> <h4>Account</h4> <a href="checkout.tpl?cart=1733169139210564329">Checkout/View Cart</a><br> <a href="customer.tpl?cart=1733169139210564329&DoThis=NewAccount">Register</a><br> <a href="login.tpl?cart=1733169139210564329">Sign In</a ><br> <h4>Contact</h4> <a href="tel:1-516-422-4100"><span class="fa fa-lg fa-phone-square fa-flip-horizontal"></span> (516) 422-4100</a><br> <a href="/cdn-cgi/l/email-protection#e281918a9290879191a281918a8ecc878697dd91978088878196dfb58780c7d0d2ab8c93978b909b"><span class="fa fa-lg fa-envelope"></span> <span class="__cf_email__" data-cfemail="3754445f47455244447754445f5b19525342">[email protected]</span></a><br> <h4>Connect with CSHL Press</h4> <a href="https://www.facebook.com/CSHPress/" title="Like us on Facebook" target="_blank"><span class="fab fa-2x fa-facebook-square"></span></a>   <a href="https://www.instagram.com/cshlpress/" title="View our photos on Instagram" target="_blank"><span class="fab fa-2x fa-instagram"></span></a>   <a href="https://www.linkedin.com/company/cshlpress" title="Connect with CSHL on Linkedin" target="_blank"><span class="fab fa-2x fa-linkedin"></span></a>; </div> </div> </div> <div id="lab-footer"> <div class="row"> <div class="column"> <h3>Main Menu</h3> <a href="https://www.cshl.edu/about-us/">About</a><br> <a href="https://www.cshl.edu/public-events/">Events</a><br> <a href="https://www.cshl.edu/news-stand/">Newsstand</a><br> <a href="https://www.cshl.edu/partner-with-us/">Partner With Us</a><br> <a href="https://www.cshl.edu/about-us/careers/">Careers</a><br> <a href="https://www.cshl.edu/giving/">Giving</a><br> <a href="https://www.cshl.edu/education/">Educational Programs</a><br> <a href="https://www.cshl.edu/research/faculty-staff/">Faculty</a><br> </div> <div class="column"> <h3>Divisions</h3> <a href="https://www.cshl.edu/research/">Research</a><br> <a href="https://www.cshl.edu/banbury/">Banbury Center</a><br> <a href="https://www.cshl.edu/cold-spring-harbor-laboratory-press/">CSHL Press</a><br> <a href="https://www.cshl.edu/dna-learning-center/">DNA Learning Center</a><br> <a href="https://www.cshl.edu/meetings-courses-program/">Meetings & Courses Program</a><br> <a href="https://www.cshl.edu/phd-program/">Ph.D. Program</a><br> </div> <div class="column"> <h3>Resources</h3> <a href="https://www.cshl.edu/education/library-archives/">Library & Archives</a><br> <a href="https://www.cshl.edu/partner-with-us/preprints/">Preprints</a><br> </div> <div class="column"> <h3>Contact</h3> <p> <a href="tel:1-516-367-8800"><span class="fa fa-lg fa-phone-square fa-flip-horizontal"></span> (516) 367-8800</a><br>  <a href="https://www.cshl.edu/about-us/directions/"><span class="fa fa-lg fa-map"></span> Maps & Directions</a><br> </p> <p> <a href="https://give.cshl.edu/" class="button"><span class="fa fa-gift"></span> Donate Now</a> </p> <p> <a href="https://www.cshl.edu/news-stand/newsletter/" class="button"><span class="fa fa-envelope"></span> Newsletter</a> </p> <h3>Connect with CSHL</h3> <p class="social"> <a href="https://www.facebook.com/cshlnews" title="Like us on Facebook" target="_blank"><span class="fab fa-2x fa-facebook-square"></span></a>   <a href="https://twitter.com/cshl" title="Follow us on Twitter" target="_blank"><span class="fab fa-2x fa-twitter"></span></a>   <a href="https://instagram.com/cshlnews" title="View our photos on Instagram" target="_blank"><span class="fab fa-2x fa-instagram"></span></a>   <a href="https://www.youtube.com/ColdSpringHarborLab" title="Visit CSHL on Youtube" target="_blank"><span class="fab fa-2x fa-youtube"></span></a>   <a href="https://www.linkedin.com/company/cold-spring-harbor-laboratory/" title="Connect with CSHL on Linkedin" target="_blank"><span class="fab fa-2x fa-linkedin"></span></a>   <a href="https://flipboard.com/@CSHL" title="Follow CSHL magazines on Flipboard" target="_blank"><span class="fab fa-flipboard fa-2x"></span></a>   <a href="https://www.cshl.edu/feed" title="CSHL RSS feed" target="_blank"><span class="fa fa-2x fa-rss"></span></a> </p> </div> </div> </div> <div id="copyright-footer"> <div class="row"> <div class="column"> <p>© <span id="year"></span> Cold Spring Harbor Laboratory. All Rights Reserved.</p> </div> <div class="column"> <p class="text-center">One Bungtown Road, Cold Spring Harbor, NY 11724</p> </div> <div class="column"> <p class="text-right"><a href="https://www.cshl.edu/about-us/sitemap/">Sitemap</a> | <a href="https://www.cshl.edu/about-us/privacy-policy/">Privacy Policy</a></p> </div> </div> </div> <script data-cfasync="false" src="/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script><script> var year = new Date().getFullYear(); document.getElementById("year").innerHTML = year; </script> </footer> <script> (function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){ (i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o), m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m) })(window,document,'script','//www.google-analytics.com/analytics.js','ga'); ga('create', 'UA-743586-7', 'cshlpress.com'); ga('send', 'pageview'); </script>   <script async src="https://www.googletagmanager.com/gtag/js?id=G-F17NQ8SLMP"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-F17NQ8SLMP'); </script> </body> </html>

CINXE.COM

CSHLPress.com - nuclear pores cell cancer