Development, Potential Anticancer Activity and the Receptor Profile of Different Functionalized 1,3,5-Triazine Derivatives

<!DOCTYPE html> <html lang="en"> <head>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-9F3B5VV3T3"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-9F3B5VV3T3'); </script> <meta charset="utf-8"> <title> Development, Potential Anticancer Activity and the Receptor Profile of Different Functionalized 1,3,5-Triazine Derivatives | Bentham Science </title> <meta content="IE=edge" http-equiv="X-UA-Compatible"> <meta content="width=device-width, initial-scale=1" name="viewport">  <meta content="rn7f90I4fqPoY23oJdeFtB1DArtCFPwLk89sWhGg" name="csrf-token">  <meta name="description" content="1,3,5-Triazine-based compounds form a privileged class of compounds in the medicinal chemistry field as they are versatile synthetic scaffolds possessing " /> <meta name="keywords" content="Development, Potential Anticancer Activity and the Receptor Profile of Different Functionalized 1,3,5-Triazine Derivatives"> <meta property="og:type" content="website" /> <meta property="og:title" content="Development, Potential Anticancer Activity and the Receptor Profile of Different Functionalized 1,3,5-Triazine Derivatives" /> <meta property="og:url" content="https://www.eurekaselect.com/article/86035" /> <meta property="og:image" content="http://www.eurekaselect.com/images/bentham/mrmc-2020.jpg" /> <meta property="og:description" content="1,3,5-Triazine-based compounds form a privileged class of compounds in the medicinal chemistry field as they are versatile synthetic scaffolds possessing wide spectra of biological effects including potential anticancer activity. 1,3,5-Triazine compounds explored for anticancer activities have been reported to act by various mechanisms on several molecular targets in human cells such as methyltransferase (DNMT), heat shock protein 90 (Hsp90) and phosphoinositide 3-kinase (PI3K). This review focuses on the synthetic strategies for current developments of 1,3,5-triazine-based anticancer agents and discuses the docking studies that confirm their unique binding modes in the targeted receptors active sites. This article also aims to highlight the future directions for the easy access to these frameworks of more potent and specific anticancer activity." /> <meta property="og:site_name" content="http://www.eurekaselect.com" /> <meta name="citation_title" content="Development, Potential Anticancer Activity and the Receptor Profile of Different Functionalized 1,3,5-Triazine Derivatives" /> <meta name="citation_author" content="Mona O. Sarhan" /> <meta name="citation_author" content="Mohamed A. Motaleb" /> <meta name="citation_author" content=" Ismail T. Ibrahim" /> <meta name="citation_author" content=" Manal M. Anwar" /> <meta name="citation_author" content=" Wafaa. A. Zaghary" /> <meta name="citation_publish_on" content="2017-09-27 " /> <meta name="citation_journal_title" content="Mini-Reviews in Medicinal Chemistry"> <meta name="citation_volume" content="18"> <meta name="citation_issue" content="15"> <meta name="citation_firstpage" content="1302"> <meta name="citation_lastpage" content="1320"> <meta name="citation_pdf_url" content="http://www.eurekaselect.com/article/86035"> <meta name="citation_doi" content="10.2174/1389557517666170927160256" /> <script defer="" src="https://www.eurekaselect.com/js/app.js"></script> <script type="text/javascript" src="https://www.eurekaselect.com/js/jquery.min.js"></script>  <script src="https://www.eurekaselect.com/js/all.min.js"></script>   <link href="https://www.eurekaselect.com/css/bootstrap.min.css" rel="stylesheet"> <link href="https://www.eurekaselect.com/css/style.css" media="all" rel="stylesheet" type="text/css"> <link href="https://www.eurekaselect.com/plugins/animate-hover/hover-min.css" 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</div> </div> <div class="col-md-12 mt-3"> <a href="https://www.eurekaselect.com" class="btn btn-outline-light btn-sm">Back</a> <div class="dropdown d-inline"> <button class="btn btn-light btn-sm dropdown-toggle" type="button" id="dropdownMenuButton" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Journal </button> <div class="dropdown-menu" aria-labelledby="dropdownMenuButton"> <a class="dropdown-item" href="https://www.eurekaselect.com/journal/56">Journal Home</a> <a class="dropdown-item" href="/journal/56/about-journal">About Journal</a> <a class="dropdown-item" href="/journal/56/editorial-board">Editorial Board</a> <a class="dropdown-item" href="http://www.minireviewsinmedicinalchemistry.com/" target="_blank">Journal Insight</a> <a class="dropdown-item" href="/journal/56/current-issue">Current Issue </a> <a class="dropdown-item" href="https://www.eurekaselect.com/journal/56">Volumes/Issues</a> </div> </div> <a href="https://www.eurekaselect.com/subscribe-to-this-journal/56" class="btn btn-light btn-sm">Subscribe</a> </div> </div> </div> <div id="side-b" class="col-md-7"> <span class="badge badge-pill badge-info mb-2">General Review Article</span> <h1>Development, Potential Anticancer Activity and the Receptor Profile of Different Functionalized 1,3,5-Triazine Derivatives</h1> <span class="l-h-3"><strong>Author(s):</strong> <a href="javascript:void(0)" class="text-secondary" title="Affiliation" data-html="true" data-toggle="popover" data-placement="bottom" data-trigger="hover" data-content="<ul><li>Labeled Compound Department, Egyptian Atomic Energy Authority, P.O. Box 13759, Cairo,Egypt </li></ul>">Mona O. Sarhan</a>, <a href="javascript:void(0)" class="text-secondary" title="Affiliation" data-html="true" data-toggle="popover" data-placement="bottom" data-trigger="hover" data-content="<ul><li>Labeled Compound Department, Egyptian Atomic Energy Authority, P.O. Box 13759, Cairo,Egypt </li></ul>">Mohamed A. Motaleb</a>, <a href="javascript:void(0)" class="text-secondary" title="Affiliation" data-html="true" data-toggle="popover" data-placement="bottom" data-trigger="hover" data-content="<ul><li>Labeled Compound Department, Egyptian Atomic Energy Authority, P.O. Box 13759, Cairo,Egypt </li></ul>"> Ismail T. Ibrahim</a>, <a href="javascript:void(0)" class="text-secondary" title="Affiliation" data-html="true" data-toggle="popover" data-placement="bottom" data-trigger="hover" data-content="<ul><li>Department of Therapeutical Chemistry, National Research Centre, Dokki, Cairo 12622,Egypt </li></ul>"> Manal M. Anwar*</a> and <a href="javascript:void(0)" class="text-secondary" title="Affiliation" data-html="true" data-toggle="popover" data-placement="bottom" data-trigger="hover" data-content="<ul><li>Department of Pharmaceutical Chemistry, College of Pharmacy, Helwan University, Cairo 11795,Egypt </li></ul>"> Wafaa. A. Zaghary*</a> </span> <div class="row"> <div class="col-md-8"> <p>Volume 18, Issue 15, 2018 </p>  <p><strong>Page:</strong> [1302 - 1320] <span class="float-right"><strong>Pages:</strong> 19 </span></p> <p><strong>DOI:</strong> <a href="http://dx.doi.org/10.2174/1389557517666170927160256" class="btn-link">10.2174/1389557517666170927160256</a></p> <p><strong>Price:</strong> $65</a></p> </div> <form method="POST" action="https://www.eurekaselect.com/cart" id="addtocartForm"> <input type="hidden" name="_token" value="rn7f90I4fqPoY23oJdeFtB1DArtCFPwLk89sWhGg" autocomplete="off"> <input type="hidden" name="param" value="eyJpdiI6IjNVMnVzbnNWUlFKVFh4em9vTVZuQUE9PSIsInZhbHVlIjoibnFRK1FpdDFLaUZrNStUMUNxaEoydz09IiwibWFjIjoiNTFhNjY1ZDJmMzlhYjE3ZjljYzc5YzZiODc1NTM3ZTdmNjdjMmY0ZjllZWNiNTg3Mjg4ZmYyMTQ0YWFkZWIxOSIsInRhZyI6IiJ9"> <div class="col-md-4 text-right"> <button type="submit" id="addcartbtn" class="btn btn-download hvr-icon-hang">Purchase<br>PDF<br><i class="fas fa-cart-plus hvr-icon"></i></button> </div> </form> </div> </div> </div> </div> </section>   <main id="article"> <section> <div class="container"> <div class="row"> <div class="col-md-8">  <div class="row text-center mb-4 ebm-banners"> <div class="col-md-3 pr-md-0 mb-2 mb-md-0"> <a href="/journal/56/become_ebm_form"><img src="/images/ebm.png" class="img-thumbnail"></a> </div> <div class="col-md-3 pr-md-0 mb-2 mb-md-0"> <a href="/journal/56/become_reviewer_form"><img src="/images/reviewer.png" class="img-thumbnail"></a> </div> <div class="col-md-3 pr-md-0 mb-2 mb-md-0"> <a href="/journal/56/become_editor_form"><img src="/images/editors.png" class="img-thumbnail"></a> </div> <div class="col-md-3 mb-2 mb-md-0"> <a href="/journal/56/become-a-section-editor"><img src="/images/section-editor.png" class="img-thumbnail"></a> </div> </div>  <div id="abstract" class="card bigbox-hvr-slow"> <div class="card-header"> <h5>Abstract</h5> </div> <div class="card-body"> <p class="text-justify"> 1,3,5-Triazine-based compounds form a privileged class of compounds in the medicinal chemistry field as they are versatile synthetic scaffolds possessing wide spectra of biological effects including potential anticancer activity. 1,3,5-Triazine compounds explored for anticancer activities have been reported to act by various mechanisms on several molecular targets in human cells such as methyltransferase (DNMT), heat shock protein 90 (Hsp90) and phosphoinositide 3-kinase (PI3K). This review focuses on the synthetic strategies for current developments of 1,3,5-triazine-based anticancer agents and discuses the docking studies that confirm their unique binding modes in the targeted receptors active sites. This article also aims to highlight the future directions for the easy access to these frameworks of more potent and specific anticancer activity. </p> <p><strong>Keywords: </strong> <a target="_blank" class="btn-link" href="https://www.eurekaselect.com/search?searchvalue=Anticancer">Anticancer</a>, <a target="_blank" class="btn-link" href="https://www.eurekaselect.com/search?searchvalue= enzymes"> enzymes</a>, <a target="_blank" class="btn-link" href="https://www.eurekaselect.com/search?searchvalue= molecular docking"> molecular docking</a>, <a target="_blank" class="btn-link" href="https://www.eurekaselect.com/search?searchvalue= synthetic methods"> synthetic methods</a>, <a target="_blank" class="btn-link" href="https://www.eurekaselect.com/search?searchvalue= 1"> 1</a>, <a target="_blank" class="btn-link" href="https://www.eurekaselect.com/search?searchvalue=3">3</a>, <a target="_blank" class="btn-link" href="https://www.eurekaselect.com/search?searchvalue=5-triazines">5-triazines</a>, <a target="_blank" class="btn-link" href="https://www.eurekaselect.com/search?searchvalue= anti-protozoals."> anti-protozoals.</a> </p> </div> </div> <div class="card-body"> <a href="https://www.eurekaselect.com/article/81621" class="float-left btn btn-primary btn-sm active" data-mdb-toggle="button" autocomplete="off" aria-pressed="true">« Previous</a> <a href="https://www.eurekaselect.com/article/89411" class="float-right btn btn-primary btn-sm active" data-mdb-toggle="button" autocomplete="off" aria-pressed="true">Next »</a> </div> <div id="abstract" class="card bigbox-hvr-slow mt-4"> <div class="card-header"> <h5>Graphical Abstract</h5> </div> <div class="card-body"> <p class="text-center"> <a href="javascript:void(0);" title="Click to enlarge"><img src="https://www.eurekaselect.com/images/graphical-abstract/mrmc/18/15/007.jpg" data-high-res-src="https://www.eurekaselect.com/images/graphical-abstract/mrmc/18/15/big-007.jpg" alt="" class="gallery-items img-thumbnail"> </a> <p> </div> </div> <br>  <div class="row mx-0"> <div class="col-lg-auto download-bar text-sm-center p-2 mr-md-3 bg-siteblue rounded"> <div class="btn-group"> <form id="markItemForm" method="POST" action="https://www.eurekaselect.com/marklist"> <input type="hidden" name="_token" value="rn7f90I4fqPoY23oJdeFtB1DArtCFPwLk89sWhGg" autocomplete="off"> <input type="hidden" name="param" value="eyJpdiI6InFISlBuclAwK280VG43MEl5bUtsWGc9PSIsInZhbHVlIjoiUW1lZ2pkSTdjaFhzREpUK3E4dEE1dz09IiwibWFjIjoiMjRjNjA2M2YxZDIxODRmYmQxMjllY2QzZjdmMzIyYmJiYzA4OWJjMzEzYTMwZjBlMWMwNmM3OGI4ODllNDRlNiIsInRhZyI6IiJ9"> <input type="hidden" name="itemtype" value="1"> <button type="submit" id="markitembtn" class="btn btn-light bg-white btn-sm">Mark Item</button> </form> </div> <div class="btn-group"> <form id="addtocartForm" method="POST" action="https://www.eurekaselect.com/cart"> <input type="hidden" name="_token" value="rn7f90I4fqPoY23oJdeFtB1DArtCFPwLk89sWhGg" autocomplete="off"> <input type="hidden" name="param" value="eyJpdiI6InFMaU92Rk9Ma0puRkk3SkdXWnp4RVE9PSIsInZhbHVlIjoiY0QzdkpXeHNuOVZLSVZjSU9zMWxNZz09IiwibWFjIjoiOWM3YTYyNjE4YWY4OWEzNmMyOTgxNTI3MmM4ZDVmN2ZlYmUyMmY5NzI4NmU3NzI2OTA1N2YzOWFlYWJiZjMwZSIsInRhZyI6IiJ9"> <button type="submit" id="addcartbtn" class="btn btn-light bg-white btn-sm">Purchase PDF</button> </form> </div> <a class="btn btn-light bg-white btn-sm" href="javascript:void(0);" id="RightsLinkPopUp">Rights & Permissions</a> <a class="btn btn-light bg-white btn-sm" href="javascript:void(0);" data-toggle="modal" data-target="#PrintWindow">Print</a> <a class="btn btn-light bg-white btn-sm" href="javascript:void(0);" data-toggle="modal" data-target="#ExportWindow">Cite</a>  </div>  <div class="modal fade" id="PrintWindow" role="dialog"> <div class="modal-dialog modal-lg"> <div class="modal-content"> <div class="modal-header"> <h4 class="modal-title" id="modalLabelprimary">Mini-Reviews in Medicinal Chemistry</h4> </div> <div class="modal-body "> <p><strong>Title:</strong>Development, Potential Anticancer Activity and the Receptor Profile of Different Functionalized 1,3,5-Triazine Derivatives</p> <p><strong>Volume:</strong> 18 <strong>Issue:</strong> 15 </p> <p><strong>Author(s): </strong>Mona O. Sarhan, Mohamed A. Motaleb, Ismail T. Ibrahim, Manal M. Anwar* Wafaa. A. Zaghary*</p> <p><strong>Affiliation: </strong><ul></ul><ul></ul><ul></ul><ul><li>Department of Therapeutical Chemistry, National Research Centre, Dokki, Cairo 12622,Egypt </li></ul><ul><li>Department of Pharmaceutical Chemistry, College of Pharmacy, Helwan University, Cairo 11795,Egypt </li></ul></p> <p><strong>Keywords:</strong> <a target="_blank" class="btn-link" href="https://www.eurekaselect.com/search?searchvalue=Anticancer">Anticancer</a>, <a target="_blank" class="btn-link" href="https://www.eurekaselect.com/search?searchvalue= enzymes"> enzymes</a>, <a target="_blank" class="btn-link" href="https://www.eurekaselect.com/search?searchvalue= molecular docking"> molecular docking</a>, <a target="_blank" class="btn-link" href="https://www.eurekaselect.com/search?searchvalue= synthetic methods"> synthetic methods</a>, <a target="_blank" class="btn-link" href="https://www.eurekaselect.com/search?searchvalue= 1"> 1</a>, <a target="_blank" class="btn-link" href="https://www.eurekaselect.com/search?searchvalue=3">3</a>, <a target="_blank" class="btn-link" href="https://www.eurekaselect.com/search?searchvalue=5-triazines">5-triazines</a>, <a target="_blank" class="btn-link" href="https://www.eurekaselect.com/search?searchvalue= anti-protozoals."> anti-protozoals.</a> </p> <p><strong>Abstract:</strong> 1,3,5-Triazine-based compounds form a privileged class of compounds in the medicinal chemistry field as they are versatile synthetic scaffolds possessing wide spectra of biological effects including potential anticancer activity. 1,3,5-Triazine compounds explored for anticancer activities have been reported to act by various mechanisms on several molecular targets in human cells such as methyltransferase (DNMT), heat shock protein 90 (Hsp90) and phosphoinositide 3-kinase (PI3K). This review focuses on the synthetic strategies for current developments of 1,3,5-triazine-based anticancer agents and discuses the docking studies that confirm their unique binding modes in the targeted receptors active sites. This article also aims to highlight the future directions for the easy access to these frameworks of more potent and specific anticancer activity.</p> </div> <div class="modal-footer"> <button type="button" class="btn btn-outline-dark" data-dismiss="modal">Close</button> <button type="button" class="btn btn-outline-primary" data-dismiss="modal" onclick="SendForPrint()">Print this page</button> </div> </div> </div> </div>   <div class="modal fade" id="ExportWindow" role="dialog"> <div class="modal-dialog"> <div class="modal-content"> <div class="modal-header"> <h4 class="modal-title">Export Options</h4> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> <div class="modal-body"> <form method="post" action="https://www.eurekaselect.com/citation" enctype="multipart/form-data" accept-charset="UTF-8" id="export-citation-form"> <input type="hidden" name="_token" value="rn7f90I4fqPoY23oJdeFtB1DArtCFPwLk89sWhGg"> <input type="hidden" name="article_id" value="86035"> <div class="form-group"> <label><strong>Export File:</strong> </label> <div class="custom-control custom-radio" id="edit-export-file-ris-wrapper"> <input type="radio" id="edit-export-file-ris" name="export_file" value="ris" checked="checked" class="custom-control-input"> <label class="custom-control-label" for="edit-export-file-ris"> RIS (for EndNote, Reference Manager, ProCite)</label> </div> <div class="custom-control custom-radio" id="edit-export-file-bibtex-wrapper"> <input type="radio" id="edit-export-file-bibtex" name="export_file" value="bibtex" class="custom-control-input"> <label class="custom-control-label" for="edit-export-file-bibtex"> BibTeX</label> </div> <div class="custom-control custom-radio" id="edit-export-file-text-wrapper"> <input type="radio" id="edit-export-file-text" name="export_file" value="text" class="custom-control-input"> <label class="custom-control-label" for="edit-export-file-text"> Text</label> </div> </div> <div class="form-group"> <label><strong>Content:</strong> </label> <div class="custom-control custom-radio" id="edit-content-citation-wrapper"> <input type="radio" id="edit-content-citation" name="content" value="citation" class="custom-control-input"> <label class="custom-control-label" for="edit-content-citation"> Citation Only</label> </div> <div class="custom-control custom-radio" id="edit-content-citation-abstract-wrapper"> <input type="radio" id="edit-content-citation-abstract" name="content" value="citation_abstract" checked="checked" class="custom-control-input"> <label class="custom-control-label" for="edit-content-citation-abstract"> Citation and Abstract</label> </div> <input type="submit" name="op" id="edit-export" value="Export" onclick="javascript:return checkradio()" class="btn btn-outline-primary float-right"> <input type="hidden" name="export_file_hidden" id="edit-export-file-hidden" value=""> <input type="hidden" name="content_hidden" id="edit-content-hidden" value=""> <input type="hidden" name="form_build_id" id="form-278487bec247e2f69b37fa03b10b8556" value="form-278487bec247e2f69b37fa03b10b8556"> <input type="hidden" name="form_id" id="edit-export-citation-form" value="export_citation_form"> </div> </form> </div> </div> </div> </div>   <div class="modal fade" id="CiteWindow" role="dialog"> <div class="modal-dialog modal-lg"> <div class="modal-content"> <div class="modal-header"> <h4 class="modal-title">About this article</h4> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> <div class="modal-body "> <p><strong>Cite this article as:</strong></p> <p> Sarhan O. 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Wafaa. *, Development, Potential Anticancer Activity and the Receptor Profile of Different Functionalized 1,3,5-Triazine Derivatives, Mini-Reviews in Medicinal Chemistry 2018; 18 (15) . <a href="https://dx.doi.org/10.2174/1389557517666170927160256">https://dx.doi.org/10.2174/1389557517666170927160256</a> </p> <table class="table"> <tr> <td><b>DOI</b><br><a href="https://dx.doi.org/10.2174/1389557517666170927160256">https://dx.doi.org/10.2174/1389557517666170927160256</a></td> <td><b>Print ISSN</b><br>1389-5575</td> </tr> <tr> <td><b>Publisher Name</b><br>Bentham Science Publisher</td> <td><b>Online ISSN</b><br>1875-5607</td> </tr> </table> </div> <div class="modal-footer"> <button type="button" class="btn btn-outline-dark" data-dismiss="modal">Close</button> <a class="btn btn-outline-primary" href="/journal/56/about-journal" target="_blank">About this journal</a> </div> </div> </div> </div>  <div class="col pl-md-0 mt-xs-2 pt-md-2"> <span class="sharethis-inline-share-buttons st-left st-inline-share-buttons st-animated" data-url="https://www.eurekaselect.com/article/86035" data-title="Development, Potential Anticancer Activity and the Receptor Profile of Different Functionalized 1,3,5-Triazine Derivatives"></span> </div>   </div> <div class="row mt-4 mb-4 mb-md-0 d-none d-md-block" id="related"> <div class="col-md-12"> <h3>Call for Papers in Thematic Issues</h3> <div class="row" id="reco-article"> <div class="col-md-6 m-0 mt-0 mb-2"> <div class="card shadow h-100 m-1"> <div class="card-header bg-white pb-1"> <label class="mr-2"><b>Submission closes on :</b></label> <span class="text-black"> 31 December, 2025 </span> </div> <div class="card-body py-2"> <a class="m-0 p-0" href="https://www.eurekaselect.com/call-for-papers-detail/5854/specialissue"> <h5 class="m-0 p-0">Bioprospecting of Natural Products as Sources of New Multitarget Therapies</h5> </a> <p class="text-black-50 mt-2 mb-0">According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. 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Development, Potential Anticancer Activity and the Receptor Profile of Different Functionalized 1,3,5-Triazine Derivatives | Bentham Science