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<!DOCTYPE html> <html lang="en" class="no-js"> <head> <meta charset="UTF-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="applicable-device" content="pc,mobile"> <meta name="viewport" content="width=device-width, initial-scale=1"> <meta name="robots" content="max-image-preview:large"> <meta name="access" content="No"> <meta name="360-site-verification" content="1268d79b5e96aecf3ff2a7dac04ad990" /> <title>Biomaterials/Tissue Interactions: Possible Solutions to Overcome Foreign Body Response | The AAPS Journal </title> <meta name="twitter:site" content="@SpringerLink"/> <meta name="twitter:card" content="summary_large_image"/> <meta name="twitter:image:alt" content="Content cover image"/> <meta name="twitter:title" content="Biomaterials/Tissue Interactions: Possible Solutions to Overcome Foreign Body Response"/> <meta name="twitter:description" content="The AAPS Journal - In recent years, a variety of biomaterial implantable devices has been developed. Of particular significance to pharmaceutical sciences is the progress made on the development of..."/> <meta name="twitter:image" content="https://static-content.springer.com/image/art%3A10.1208%2Fs12248-010-9175-3/MediaObjects/12248_2010_9175_Fig1_HTML.gif"/> <meta name="journal_id" content="12248"/> <meta name="dc.title" content="Biomaterials/Tissue Interactions: Possible Solutions to Overcome Foreign Body Response"/> <meta name="dc.source" content="The AAPS Journal 2010 12:2"/> <meta name="dc.format" content="text/html"/> <meta name="dc.publisher" content="Springer"/> <meta name="dc.date" content="2010-02-09"/> <meta name="dc.type" content="OriginalPaper"/> <meta name="dc.language" content="En"/> <meta name="dc.copyright" content="2010 American Association of Pharmaceutical Scientists"/> <meta name="dc.rights" content="2010 American Association of Pharmaceutical Scientists"/> <meta name="dc.rightsAgent" content="journalpermissions@springernature.com"/> <meta name="dc.description" content="In recent years, a variety of biomaterial implantable devices has been developed. Of particular significance to pharmaceutical sciences is the progress made on the development of drug/implantable device combination products. However, the clinical application of these devices is still a critical issue due to the host response, which results from both the tissue trauma during implantation and the presence of the device in the body. Accordingly, the in vivo functionality and durability of any implantable device can be compromised by the body response to the foreign material. Numerous strategies to overcome negative body reactions have been reported. The aim of this review is to outline some key issues of biomaterial/tissue interactions such as foreign body response and biocompatibility and biocompatibility assessment. In addition, general approaches used to overcome the in vivo instability of implantable devices are presented, including (a) biocompatible material coatings, (b) steroidal and nonsteroidal anti-inflammatory drugs, and (c) angiogenic drugs. In particular, strategies to overcome host response to glucose biosensors are summarized."/> <meta name="prism.issn" content="1550-7416"/> <meta name="prism.publicationName" content="The AAPS Journal"/> <meta name="prism.publicationDate" content="2010-02-09"/> <meta name="prism.volume" content="12"/> <meta name="prism.number" content="2"/> <meta name="prism.section" content="OriginalPaper"/> <meta name="prism.startingPage" content="188"/> <meta name="prism.endingPage" content="196"/> <meta name="prism.copyright" content="2010 American Association of Pharmaceutical Scientists"/> <meta name="prism.rightsAgent" content="journalpermissions@springernature.com"/> <meta name="prism.url" content="https://link.springer.com/article/10.1208/s12248-010-9175-3"/> <meta name="prism.doi" content="doi:10.1208/s12248-010-9175-3"/> <meta name="citation_pdf_url" content="https://link.springer.com/content/pdf/10.1208/s12248-010-9175-3.pdf"/> <meta name="citation_fulltext_html_url" content="https://link.springer.com/article/10.1208/s12248-010-9175-3"/> <meta name="citation_journal_title" content="The AAPS Journal"/> <meta name="citation_journal_abbrev" content="AAPS J"/> <meta name="citation_publisher" content="Springer US"/> <meta name="citation_issn" content="1550-7416"/> <meta name="citation_title" content="Biomaterials/Tissue Interactions: Possible Solutions to Overcome Foreign Body Response"/> <meta name="citation_volume" content="12"/> <meta name="citation_issue" content="2"/> <meta name="citation_publication_date" content="2010/06"/> <meta name="citation_online_date" content="2010/02/09"/> <meta name="citation_firstpage" content="188"/> <meta name="citation_lastpage" content="196"/> <meta name="citation_article_type" content="Review Article"/> <meta name="citation_language" content="en"/> <meta name="dc.identifier" content="doi:10.1208/s12248-010-9175-3"/> <meta name="DOI" content="10.1208/s12248-010-9175-3"/> <meta name="size" content="232622"/> <meta name="citation_doi" content="10.1208/s12248-010-9175-3"/> <meta name="citation_springer_api_url" content="http://api.springer.com/xmldata/jats?q=doi:10.1208/s12248-010-9175-3&api_key="/> <meta name="description" content="In recent years, a variety of biomaterial implantable devices has been developed. Of particular significance to pharmaceutical sciences is the progress mad"/> <meta name="dc.creator" content="Morais, Jacqueline M."/> <meta name="dc.creator" content="Papadimitrakopoulos, Fotios"/> <meta name="dc.creator" content="Burgess, Diane J."/> <meta name="dc.subject" content="Pharmacology/Toxicology"/> <meta name="dc.subject" content="Biochemistry, general"/> <meta name="dc.subject" content="Biotechnology"/> <meta name="dc.subject" content="Pharmacy"/> <meta name="citation_reference" content="citation_journal_title=Ann NY Acad Sci; citation_title=Bioartificial organs in the twenty-first century: nano-biological devices; citation_author=A Prokop; citation_volume=944; citation_publication_date=2001; citation_pages=472-490; citation_id=CR1"/> <meta name="citation_reference" content="citation_journal_title=Clin Chem; citation_title=Progress toward the development of an implantable sensor for glucose; citation_author=GS Wilson, Y Zhang, G Reach, D Moatti-Sirat, V Poitout, DR Thévenot; 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Of particular significance to pharmaceutical sciences is the progress made on the development of drug/implantable device combination products. However, the clinical application of these devices is still a critical issue due to the host response, which results from both the tissue trauma during implantation and the presence of the device in the body. Accordingly, the in vivo functionality and durability of any implantable device can be compromised by the body response to the foreign material. Numerous strategies to overcome negative body reactions have been reported. The aim of this review is to outline some key issues of biomaterial/tissue interactions such as foreign body response and biocompatibility and biocompatibility assessment. In addition, general approaches used to overcome the in vivo instability of implantable devices are presented, including (a) biocompatible material coatings, (b) steroidal and nonsteroidal anti-inflammatory drugs, and (c) angiogenic drugs. In particular, strategies to overcome host response to glucose biosensors are summarized."/> <meta property="og:image" content="https://static-content.springer.com/image/art%3A10.1208%2Fs12248-010-9175-3/MediaObjects/12248_2010_9175_Fig1_HTML.gif"/> <meta name="format-detection" content="telephone=no"> <link rel="apple-touch-icon" sizes="180x180" href=/oscar-static/img/favicons/darwin/apple-touch-icon-92e819bf8a.png> <link rel="icon" type="image/png" sizes="192x192" href=/oscar-static/img/favicons/darwin/android-chrome-192x192-6f081ca7e5.png> <link rel="icon" type="image/png" sizes="32x32" href=/oscar-static/img/favicons/darwin/favicon-32x32-1435da3e82.png> <link rel="icon" type="image/png" sizes="16x16" href=/oscar-static/img/favicons/darwin/favicon-16x16-ed57f42bd2.png> <link rel="shortcut icon" data-test="shortcut-icon" href=/oscar-static/img/favicons/darwin/favicon-c6d59aafac.ico> <meta name="theme-color" content="#e6e6e6">   <link rel="stylesheet" media="print" 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Of particular significance to pharmaceutical sciences is the progress made on the development of drug/implantable device combination products. However, the clinical application of these devices is still a critical issue due to the host response, which results from both the tissue trauma during implantation and the presence of the device in the body. Accordingly, the in vivo functionality and durability of any implantable device can be compromised by the body response to the foreign material. Numerous strategies to overcome negative body reactions have been reported. The aim of this review is to outline some key issues of biomaterial/tissue interactions such as foreign body response and biocompatibility and biocompatibility assessment. In addition, general approaches used to overcome the in vivo instability of implantable devices are presented, including (a) biocompatible material coatings, (b) steroidal and nonsteroidal anti-inflammatory drugs, and (c) angiogenic drugs. 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Morais","affiliation":[{"name":"University of Connecticut","address":{"name":"Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, USA","@type":"PostalAddress"},"@type":"Organization"}],"@type":"Person"},{"name":"Fotios Papadimitrakopoulos","affiliation":[{"name":"University of Connecticut","address":{"name":"Department of Material Science, University of Connecticut, Storrs, USA","@type":"PostalAddress"},"@type":"Organization"}],"@type":"Person"},{"name":"Diane J. 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data-track-label="link"> Submit manuscript <svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-arrow-right-medium"></use></svg> </a> </div> </div> </div> </section> <div class="c-article-main u-container u-mt-24 u-mb-32 l-with-sidebar" id="main-content" data-component="article-container"> <main class="u-serif js-main-column" data-track-component="article body"> <div class="c-article-header"> <header> <ul class="c-article-author-list c-article-author-list--short" data-test="authors-list" data-component-authors-activator="authors-list"><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Jacqueline_M_-Morais-Aff1" data-author-popup="auth-Jacqueline_M_-Morais-Aff1" data-author-search="Morais, Jacqueline M.">Jacqueline M. Morais</a><sup class="u-js-hide"><a href="#Aff1">1</a></sup>, </li><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Fotios-Papadimitrakopoulos-Aff2" data-author-popup="auth-Fotios-Papadimitrakopoulos-Aff2" data-author-search="Papadimitrakopoulos, Fotios">Fotios Papadimitrakopoulos</a><sup class="u-js-hide"><a href="#Aff2">2</a></sup> & </li><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Diane_J_-Burgess-Aff1" data-author-popup="auth-Diane_J_-Burgess-Aff1" data-author-search="Burgess, Diane J." data-corresp-id="c1">Diane J. Burgess<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-mail-medium"></use></svg></a><sup class="u-js-hide"><a href="#Aff1">1</a></sup> </li></ul> <div data-test="article-metrics"> <ul class="app-article-metrics-bar u-list-reset"> <li class="app-article-metrics-bar__item"> <p class="app-article-metrics-bar__count"><svg class="u-icon app-article-metrics-bar__icon" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-accesses-medium"></use> </svg>7106 <span class="app-article-metrics-bar__label">Accesses</span></p> </li> <li class="app-article-metrics-bar__item"> <p class="app-article-metrics-bar__count"><svg class="u-icon app-article-metrics-bar__icon" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-altmetric-medium"></use> </svg>12 <span class="app-article-metrics-bar__label">Altmetric</span></p> </li> <li class="app-article-metrics-bar__item app-article-metrics-bar__item--metrics"> <p class="app-article-metrics-bar__details"><a href="/article/10.1208/s12248-010-9175-3/metrics" data-track="click" data-track-action="view metrics" data-track-label="link" rel="nofollow">Explore all metrics <svg class="u-icon app-article-metrics-bar__arrow-icon" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-arrow-right-medium"></use> </svg></a></p> </li> </ul> </div> <div class="u-mt-32"> </div> </header> </div> <div data-article-body="true" data-track-component="article body" class="c-article-body"> <section aria-labelledby="Abs1" data-title="Abstract" lang="en"><div class="c-article-section" id="Abs1-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Abs1">Abstract</h2><div class="c-article-section__content" id="Abs1-content"><p>In recent years, a variety of biomaterial implantable devices has been developed. Of particular significance to pharmaceutical sciences is the progress made on the development of drug/implantable device combination products. However, the clinical application of these devices is still a critical issue due to the host response, which results from both the tissue trauma during implantation and the presence of the device in the body. Accordingly, the <i>in vivo</i> functionality and durability of any implantable device can be compromised by the body response to the foreign material. Numerous strategies to overcome negative body reactions have been reported. The aim of this review is to outline some key issues of biomaterial/tissue interactions such as foreign body response and biocompatibility and biocompatibility assessment. In addition, general approaches used to overcome the <i>in vivo</i> instability of implantable devices are presented, including (a) biocompatible material coatings, (b) steroidal and nonsteroidal anti-inflammatory drugs, and (c) angiogenic drugs. In particular, strategies to overcome host response to glucose biosensors are summarized.</p></div></div></section> <div class="c-notes"> <p class="c-notes__text c-status-message--info"> <svg width="24" height="24" focusable="false" role="img" aria-hidden="true" class="c-status-message__icon"> <use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-info-filled-medium"></use> </svg> This is a preview of subscription content, <a id="test-login-banner-link" href="//wayf.springernature.com?redirect_uri=https%3A%2F%2Flink.springer.com%2Farticle%2F10.1208%2Fs12248-010-9175-3%3Ferror%3Dcookies_not_supported%26code%3D8d3a304b-8068-44e0-be84-af1fa009db61" data-track="click" data-track-action="login" data-track-label="link" class="c-preview-message__link">log in via an institution</a> <svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon c-external-link__icon"> <use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-external-link-small"></use> </svg> to check access. </p> </div> <div data-test="access-article" class="app-article-access"> <h2 class="app-article-access__heading">Access this article</h2> <div class="u-ma-16 u-clear-both"> <a href="//wayf.springernature.com?redirect_uri=https%3A%2F%2Flink.springer.com%2Farticle%2F10.1208%2Fs12248-010-9175-3%3Ferror%3Dcookies_not_supported%26code%3D8d3a304b-8068-44e0-be84-af1fa009db61" class="u-button u-button--full-width u-button--primary u-justify-content-space-between c-pdf-download__link" data-track="click" data-track-action="institution access" data-track-label="button"> <span data-test="access-via-institution">Log in via an institution</span> <svg aria-hidden="true" focusable="false" width="24" height="24" class="u-icon"> <use xlink:href="#icon-eds-i-arrow-right-medium"></use> </svg> </a> </div> <div data-test="buy-box-mobile" class="c-article-buy-box"> <div class="sprcom-buybox-articleDarwin" id="sprcom-buybox-articleDarwin">  <div class="buying-option" data-test-id="buy-article-darwin"> <div> <div class="c-springer-plus"> <h2 class="springer-plus-heading">Subscribe and save</h2> <div class="springer-plus"> <div class="springer-plus-headline"> <div class="springer-plus-title"> <svg aria-hidden="true" focusable="false" width="16" height="16" class="u-icon"> <use xlink:href="#icon-eds-i-check-filled-medium"></use> </svg><span>Springer+ Basic</span> </div> <div class="dd price-amount-springer-plus"> €32.70 /Month </div> </div> <ul class="buying-option-usps"> <li>Get 10 units per month</li> <li>Download Article/Chapter or eBook</li> <li>1 Unit = 1 Article or 1 Chapter</li> <li>Cancel anytime</li> </ul><a href="https://link.springer.com/product/springer-plus" id="btn-subscribe-springerPlus" class="u-button u-button--full-width u-button--secondary" data-track="click||click_springer_subscribe" data-track-context="buy box"><span>Subscribe now </span> <svg aria-hidden="true" focusable="false" width="16" height="16" class="u-icon"> <use xlink:href="#icon-eds-i-arrow-right-medium"></use> </svg></a> </div> <h2 class="springer-plus-heading">Buy Now</h2> </div> <div class="buybox__buy"> <form action="https://order.springer.com/public/cart" method="post"> <input type="hidden" name="type" value="article"><input type="hidden" name="doi" value="10.1208/s12248-010-9175-3"><input type="hidden" name="isxn" value="1550-7416"><input type="hidden" name="contenttitle" value="Biomaterials/Tissue Interactions: Possible Solutions to Overcome Foreign Body Response"><input type="hidden" name="copyrightyear" value="2010"><input type="hidden" name="year" value="2010"><input type="hidden" name="authors" value="Jacqueline M. 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Morais & Diane J. Burgess</p></li><li id="Aff2"><p class="c-article-author-affiliation__address">Department of Material Science, University of Connecticut, Storrs, Connecticut, 06269, USA</p><p class="c-article-author-affiliation__authors-list">Fotios Papadimitrakopoulos</p></li></ol><div class="u-js-hide u-hide-print" data-test="author-info"><span class="c-article__sub-heading">Authors</span><ol class="c-article-authors-search u-list-reset"><li id="auth-Jacqueline_M_-Morais-Aff1"><span class="c-article-authors-search__title u-h3 js-search-name">Jacqueline M. 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Burgess</span><div class="c-article-authors-search__list"><div class="c-article-authors-search__item c-article-authors-search__list-item--left"><a href="/search?dc.creator=Diane%20J.%20Burgess" class="c-article-button" data-track="click" data-track-action="author link - publication" data-track-label="link" rel="nofollow">View author publications</a></div><div class="c-article-authors-search__item c-article-authors-search__list-item--right"><p class="search-in-title-js c-article-authors-search__text">You can also search for this author in <span class="c-article-identifiers"><a class="c-article-identifiers__item" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Diane%20J.%20Burgess" data-track="click" data-track-action="author link - pubmed" data-track-label="link" rel="nofollow">PubMed</a><span class="u-hide"> </span><a class="c-article-identifiers__item" href="http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Diane%20J.%20Burgess%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en" data-track="click" data-track-action="author link - scholar" data-track-label="link" rel="nofollow">Google Scholar</a></span></p></div></div></li></ol></div><h3 class="c-article__sub-heading" id="corresponding-author">Corresponding author</h3><p id="corresponding-author-list">Correspondence to <a id="corresp-c1" href="mailto:d.burgess@uconn.edu">Diane J. 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