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.dark_mode_safe img{background-color:var(--background-color-inverted,#f8f9fa)}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .dark_mode_safe img{background-color:var(--background-color-inverted,#f8f9fa)}}</style> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Abarelix">Abarelix</span></caption><tbody><tr><td colspan="2" class="infobox-image"><span class="dark_mode_safe" typeof="mw:File"><a href="/wiki/File:Abarelix.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/53/Abarelix.svg/250px-Abarelix.svg.png" decoding="async" width="250" height="90" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/53/Abarelix.svg/375px-Abarelix.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/53/Abarelix.svg/500px-Abarelix.svg.png 2x" data-file-width="512" data-file-height="184" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Plenaxis</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/abarelix.html">Monograph</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data"><a href="/wiki/Intramuscular_injection" title="Intramuscular injection">Intramuscular injection</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_class" title="Drug class">Drug class</a></th><td class="infobox-data"><a href="/wiki/GnRH_analogue" class="mw-redirect" title="GnRH analogue">GnRH analogue</a>; <a href="/wiki/GnRH_antagonist" class="mw-redirect" title="GnRH antagonist">GnRH antagonist</a>; <a href="/wiki/Antigonadotropin" title="Antigonadotropin">Antigonadotropin</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"><ul><li><a href="/wiki/ATC_code_L02" title="ATC code L02">L02BX01</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=L02BX01">WHO</a></span>) </li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;"><a href="/wiki/Pharmacokinetics" title="Pharmacokinetics">Pharmacokinetic</a> data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Plasma_protein_binding" title="Plasma protein binding">Protein binding</a></th><td class="infobox-data">96–99%</td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Identifiers</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/IUPAC_nomenclature_of_chemistry" title="IUPAC nomenclature of chemistry">IUPAC name</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;">N-acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-N-methyl-L-tyrosyl-D-asparagyl-L-leucyl-N6-isopropyl-L-lysyl-L-prolyl-D-alaninamide<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></div></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=183552-38-7">183552-38-7</a></span><sup> <span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/16131215">16131215</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Guide_to_Pharmacology" title="Guide to Pharmacology">IUPHAR/BPS</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.guidetopharmacology.org"><a rel="nofollow" class="external text" href="https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1188">1188</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB00106">DB00106</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.10482301.html">10482301</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/W486SJ5824">W486SJ5824</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D02738">D02738</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEBI" title="ChEBI">ChEBI</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:337298">CHEBI:337298</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembl/explore/compound/ChEMBL1252">ChEMBL1252</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID20171443">DTXSID20171443</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q305555#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>72</sub><span title="Hydrogen">H</span><sub>95</sub><span title="Chlorine">Cl</span><span title="Nitrogen">N</span><sub>14</sub><span title="Oxygen">O</span><sub>14</sub></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data"><span class="nowrap"><span data-sort-value="7003141609000000000♠"></span>1<span style="margin-left:.25em;">416</span>.09</span> g·mol<sup>−1</sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=CC%28C%29C%5BC%40H%5D%28NC%28%3DO%29%5BC%40%40H%5D%28CC%28N%29%3DO%29NC%28%3DO%29%5BC%40H%5D%28Cc1ccc%28O%29cc1%29N%28C%29C%28%3DO%29%5BC%40H%5D%28CO%29NC%28%3DO%29%5BC%40%40H%5D%28Cc2cccnc2%29NC%28%3DO%29%5BC%40%40H%5D%28Cc3ccc%28Cl%29cc3%29NC%28%3DO%29%5BC%40%40H%5D%28NCc5ccc4ccccc4c5%29NC%28C%29%3DO%29C%28%3DO%29N%5BC%40%40H%5D%28CCCCNC%28C%29C%29C%28%3DO%29N6CCC%5BC%40H%5D6C%28%3DO%29N%5BC%40H%5D%28C%29C%28N%29%3DO">Interactive image</a></span></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">CC(C)C[C@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@@H](NCc5ccc4ccccc4c5)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N6CCC[C@H]6C(=O)N[C@H](C)C(N)=O</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C72H95ClN14O14/c1-41(2)32-54(64(93)80-53(17-10-11-30-77-42(3)4)72(101)87-31-13-18-60(87)69(98)78-43(5)63(75)92)81-68(97)58(38-62(74)91)84-70(99)61(37-46-22-27-52(90)28-23-46)86(7)71(100)59(40-88)85-67(96)57(36-48-14-12-29-76-39-48)83-66(95)56(34-45-20-25-51(73)26-21-45)82-65(94)55(79-44(6)89)35-47-19-24-49-15-8-9-16-50(49)33-47/h8-9,12,14-16,19-29,33,39,41-43,53-61,77,88,90H,10-11,13,17-18,30-32,34-38,40H2,1-7H3,(H2,74,91)(H2,75,92)(H,78,98)(H,79,89)(H,80,93)(H,81,97)(H,82,94)(H,83,95)(H,84,99)(H,85,96)/t43-,53+,54+,55-,56-,57-,58-,59+,60+,61+/m1/s1<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:AIWRTTMUVOZGPW-HSPKUQOVSA-N<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-below"><style data-mw-deduplicate="TemplateStyles:r886047488">.mw-parser-output .nobold{font-weight:normal}</style><span class="nobold"> <sup><span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span><span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup> <a href="/wiki/Wikipedia:WikiProject_Chemicals/Chembox_validation" title="Wikipedia:WikiProject Chemicals/Chembox validation">(what is this?)</a></span><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r886047488"><span class="nobold">  <span class="reflink plainlinks nourlexpansion"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=Special:ComparePages&rev1=477237014&page2=Abarelix">(verify)</a></span></span></td></tr></tbody></table> <p><b>Abarelix</b>, sold under the brand name <b>Plenaxis</b>, is an injectable <a href="/wiki/Gonadotropin-releasing_hormone" title="Gonadotropin-releasing hormone">gonadotropin-releasing hormone</a> antagonist (<a href="/wiki/Gonadotropin-releasing_hormone_antagonist" title="Gonadotropin-releasing hormone antagonist">GnRH antagonist</a>) which is marketed in <a href="/wiki/Germany" title="Germany">Germany</a> and the <a href="/wiki/Netherlands" title="Netherlands">Netherlands</a>. It is primarily used in <a href="/wiki/Oncology" title="Oncology">oncology</a> to reduce the amount of <a href="/wiki/Testosterone" title="Testosterone">testosterone</a> made in patients with advanced symptomatic <a href="/wiki/Prostate_cancer" title="Prostate cancer">prostate cancer</a> for which no other treatment options are available.<sup id="cite_ref-Drugs.com-2_2-0" class="reference"><a href="#cite_note-Drugs.com-2-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p><p>It was originally marketed by Praecis Pharmaceuticals as <i>Plenaxis</i>,<sup id="cite_ref-Drugs.com-2_2-1" class="reference"><a href="#cite_note-Drugs.com-2-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> and is now marketed by Speciality European Pharma in Germany<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> after receiving a marketing authorization in 2005. The drug was introduced in the <a href="/wiki/United_States" title="United States">United States</a> in 2003, but was discontinued in this country in May 2005 due to poor sales and a higher-than-expected incidence of severe <a href="/wiki/Allergic_reaction" class="mw-redirect" title="Allergic reaction">allergic reactions</a>.<sup id="cite_ref-Minev2011_5-0" class="reference"><a href="#cite_note-Minev2011-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> It remains marketed in <a href="/wiki/Germany" title="Germany">Germany</a> and the <a href="/wiki/Netherlands" title="Netherlands">Netherlands</a> however.<sup id="cite_ref-Drugs.com_6-0" class="reference"><a href="#cite_note-Drugs.com-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Abarelix&action=edit&section=1" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Gonadotropin-releasing_hormone_receptor#Antagonists" title="Gonadotropin-releasing hormone receptor">Gonadotropin-releasing hormone receptor § Antagonists</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Abarelix&action=edit&section=2" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output 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q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/Abarelix">"Abarelix"</a>. <i>PubChem</i>. 2017-07-29.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=PubChem&rft.atitle=Abarelix&rft.date=2017-07-29&rft_id=https%3A%2F%2Fpubchem.ncbi.nlm.nih.gov%2Fcompound%2FAbarelix&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAbarelix" class="Z3988"></span></span> </li> <li id="cite_note-Drugs.com-2-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-Drugs.com-2_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Drugs.com-2_2-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20180210163254/https://www.drugs.com/mtm/abarelix.html">"Abarelix"</a>. <i>Drugs.com</i>. Archived from <a rel="nofollow" class="external text" href="https://www.drugs.com/mtm/abarelix.html">the original</a> on 2018-02-10<span class="reference-accessdate">. Retrieved <span class="nowrap">2018-01-23</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Drugs.com&rft.atitle=Abarelix&rft_id=https%3A%2F%2Fwww.drugs.com%2Fmtm%2Fabarelix.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAbarelix" class="Z3988"></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBoccon-Gibodvan_der_MeulenPersson2011" class="citation journal cs1">Boccon-Gibod L, van der Meulen E, Persson BE (June 2011). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159401">"An update on the use of gonadotropin-releasing hormone antagonists in prostate cancer"</a>. <i>Therapeutic Advances in Urology</i>. <b>3</b> (3): <span class="nowrap">127–</span>40. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1177%2F1756287211414457">10.1177/1756287211414457</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159401">3159401</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21904569">21904569</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Therapeutic+Advances+in+Urology&rft.atitle=An+update+on+the+use+of+gonadotropin-releasing+hormone+antagonists+in+prostate+cancer&rft.volume=3&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E127-%3C%2Fspan%3E40&rft.date=2011-06&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3159401%23id-name%3DPMC&rft_id=info%3Apmid%2F21904569&rft_id=info%3Adoi%2F10.1177%2F1756287211414457&rft.aulast=Boccon-Gibod&rft.aufirst=L&rft.au=van+der+Meulen%2C+E&rft.au=Persson%2C+BE&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3159401&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAbarelix" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text">Pharmazeutische Zeitung online: <a rel="nofollow" class="external text" href="http://www.pharmazeutische-zeitung.de/index.php?id=4760">Abarelix</a> <span class="languageicon">(in German)</span></span> </li> <li id="cite_note-Minev2011-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-Minev2011_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMinev2011" class="citation book cs1">Minev B (13 January 2011). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=mOdKDLAAd0AC&pg=PA182"><i>Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures</i></a>. Springer Science & Business Media. pp. 182–. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-90-481-9704-0" title="Special:BookSources/978-90-481-9704-0"><bdi>978-90-481-9704-0</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Cancer+Management+in+Man%3A+Chemotherapy%2C+Biological+Therapy%2C+Hyperthermia+and+Supporting+Measures&rft.pages=182-&rft.pub=Springer+Science+%26+Business+Media&rft.date=2011-01-13&rft.isbn=978-90-481-9704-0&rft.aulast=Minev&rft.aufirst=Boris&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DmOdKDLAAd0AC%26pg%3DPA182&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAbarelix" class="Z3988"></span></span> </li> <li id="cite_note-Drugs.com-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-Drugs.com_6-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20190829113846/https://www.drugs.com/international/abarelix.html">"Abarelix"</a>. <i>Drugs.com</i>. Archived from <a rel="nofollow" class="external text" href="https://www.drugs.com/international/abarelix.html">the original</a> on 2019-08-29<span class="reference-accessdate">. Retrieved <span class="nowrap">2018-08-27</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Drugs.com&rft.atitle=Abarelix&rft_id=https%3A%2F%2Fwww.drugs.com%2Finternational%2Fabarelix.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAbarelix" class="Z3988"></span></span> </li> </ol></div></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol 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class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Gonadotropin-releasing_hormone_modulator" title="Gonadotropin-releasing hormone modulator"><abbr title="Gonadotropin-releasing hormone">GnRH</abbr> modulators</a><br />(incl. <a href="/wiki/Gonadotropin-releasing_hormone_analogue" class="mw-redirect" title="Gonadotropin-releasing hormone analogue">analogues</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0;background:#DDDDFF;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/Gonadotropin-releasing_hormone_agonist" title="Gonadotropin-releasing hormone agonist">Agonists</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Peptide:</i> <a href="/wiki/Azagly-nafarelin" title="Azagly-nafarelin">Azagly-nafarelin</a></li> <li><a href="/wiki/Buserelin" title="Buserelin">Buserelin</a></li> <li><a href="/wiki/Deslorelin" title="Deslorelin">Deslorelin</a></li> <li><a href="/wiki/Fertirelin" title="Fertirelin">Fertirelin</a></li> <li><a href="/wiki/Gonadorelin" title="Gonadorelin">Gonadorelin</a></li> <li><a href="/wiki/Goserelin" title="Goserelin">Goserelin</a></li> <li><a href="/wiki/Histrelin" title="Histrelin">Histrelin</a></li> <li><a href="/wiki/Lecirelin" title="Lecirelin">Lecirelin</a></li> <li><a href="/wiki/Leuprorelin" title="Leuprorelin">Leuprorelin (leuprolide)</a></li> <li><a href="/wiki/Nafarelin" title="Nafarelin">Nafarelin</a></li> <li><a href="/wiki/Peforelin" title="Peforelin">Peforelin</a></li> <li><a href="/wiki/Triptorelin" title="Triptorelin">Triptorelin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/Gonadotropin-releasing_hormone_antagonist" title="Gonadotropin-releasing hormone antagonist">Antagonists</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Peptide:</i> <a class="mw-selflink selflink">Abarelix</a></li> <li><a href="/wiki/Cetrorelix" title="Cetrorelix">Cetrorelix</a></li> <li><a href="/wiki/Degarelix" title="Degarelix">Degarelix</a></li> <li><a href="/wiki/Ganirelix" title="Ganirelix">Ganirelix</a></li></ul> <ul><li><i>Non-peptide:</i> <a href="/wiki/Elagolix" title="Elagolix">Elagolix</a></li> <li><a href="/wiki/Linzagolix" title="Linzagolix">Linzagolix</a><sup>†</sup></li> <li><a href="/wiki/Relugolix" title="Relugolix">Relugolix</a> (<a href="/wiki/Relugolix/estradiol/norethisterone_acetate" title="Relugolix/estradiol/norethisterone acetate">+estradiol/norethisterone acetate</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Gonadotropin" title="Gonadotropin">Gonadotropins</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0;background:#DDDDFF;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Preparations41" scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/Gonadotropin_preparation" class="mw-redirect" title="Gonadotropin preparation">Preparations</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Follicle-stimulating_hormone" title="Follicle-stimulating hormone">Follicle-stimulating hormone</a></li> <li><a href="/wiki/Human_chorionic_gonadotropin" title="Human chorionic gonadotropin">Human chorionic gonadotropin</a></li> <li><a href="/wiki/Luteinizing_hormone" title="Luteinizing hormone">Luteinizing hormone</a></li> <li><a href="/wiki/Menotropin" title="Menotropin">Menotropin</a></li> <li><a href="/wiki/Urofollitropin" title="Urofollitropin">Urofollitropin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others<br />(indirect)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0;background:#DDDDFF;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:8em;;text-align:center;"><a href="/wiki/Progonadotropin" title="Progonadotropin">Progonadotropins</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Sex steroid antagonists (via disinhibition of the <a href="/wiki/Hypothalamic-pituitary-gonadal_axis" class="mw-redirect" title="Hypothalamic-pituitary-gonadal axis"><abbr title="hypothalamic–pituitary–gonadal">HPG</abbr> axis</a>):</i> <a href="/wiki/Antiandrogen" title="Antiandrogen">Antiandrogens</a> (e.g., <a href="/wiki/Flutamide" title="Flutamide">flutamide</a>, <a href="/wiki/Bicalutamide" title="Bicalutamide">bicalutamide</a>, <a href="/wiki/Enzalutamide" title="Enzalutamide">enzalutamide</a>)</li> <li><a href="/wiki/Antiestrogen" title="Antiestrogen">Antiestrogens</a>/<a href="/wiki/Selective_estrogen_receptor_modulators" class="mw-redirect" title="Selective estrogen receptor modulators"><abbr title="Selective estrogen receptor modulators">SERMs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Selective estrogen receptor modulators</span> (e.g., <a href="/wiki/Tamoxifen" title="Tamoxifen">tamoxifen</a>, <a href="/wiki/Clomifene" title="Clomifene">clomifene</a>, <a href="/wiki/Enclomifene" title="Enclomifene">enclomifene</a>)</li> <li><a href="/wiki/Aromatase_inhibitor" title="Aromatase inhibitor">Aromatase inhibitors</a> (e.g., <a href="/wiki/Anastrozole" title="Anastrozole">anastrozole</a>)</li> <li><a href="/wiki/GnRH_agonist" class="mw-redirect" title="GnRH agonist"><abbr title="gonadotropin-releasing hormone">GnRH</abbr> agonists</a> (e.g., <a href="/wiki/Gonadotropin-releasing_hormone" title="Gonadotropin-releasing hormone"><abbr title="gonadotropin-releasing hormone">GnRH</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip gonadotropin-releasing hormone</span>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:8em;;text-align:center;"><a href="/wiki/Antigonadotropin" title="Antigonadotropin">Antigonadotropins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Sex steroid agonists (via negative feedback on the <a href="/wiki/Hypothalamic-pituitary-gonadal_axis" class="mw-redirect" title="Hypothalamic-pituitary-gonadal axis"><abbr title="hypothalamic–pituitary–gonadal">HPG</abbr> axis</a>):</i> <a href="/wiki/Androgen" title="Androgen">Androgens</a>/<a href="/wiki/Anabolic_steroid" title="Anabolic steroid">anabolic steroids</a> (e.g., <a href="/wiki/Testosterone_(medication)" title="Testosterone (medication)">testosterone</a>, <a href="/wiki/Nandrolone_ester" class="mw-redirect" title="Nandrolone ester">nandrolone esters</a>, <a href="/wiki/Oxandrolone" title="Oxandrolone">oxandrolone</a>)</li> <li><a href="/wiki/D2_receptor" class="mw-redirect" title="D2 receptor">D<sub>2</sub> receptor</a> <a href="/wiki/Dopamine_antagonist" title="Dopamine antagonist">antagonists</a> (<a href="/wiki/Prolactin_releaser" class="mw-redirect" title="Prolactin releaser">prolactin releasers</a>) (incl., <a href="/wiki/Domperidone" title="Domperidone">domperidone</a>, <a href="/wiki/Metoclopramide" title="Metoclopramide">metoclopramide</a>, <a href="/wiki/Risperidone" title="Risperidone">risperidone</a>, <a href="/wiki/Haloperidol" title="Haloperidol">haloperidol</a>, <a href="/wiki/Chlorpromazine" title="Chlorpromazine">chlorpromazine</a>, <a href="/wiki/Sulpiride" title="Sulpiride">sulpiride</a>)</li> <li><a href="/wiki/Estrogen_(medication)" title="Estrogen (medication)">Estrogens</a> (incl., <a href="/wiki/Bifluranol" title="Bifluranol">bifluranol</a>, <a href="/wiki/Estradiol_(medication)" title="Estradiol (medication)">estradiol</a>, <a href="/wiki/Estradiol_ester" class="mw-redirect" title="Estradiol ester">estradiol esters</a>, <a href="/wiki/Ethinylestradiol" title="Ethinylestradiol">ethinylestradiol</a>, <a href="/wiki/Diethylstilbestrol" title="Diethylstilbestrol">diethylstilbestrol</a>, <a href="/wiki/Paroxypropione" title="Paroxypropione">paroxypropione</a>)</li> <li><a href="/wiki/Progestogen" title="Progestogen">Progestogens</a> (incl. <a href="/wiki/Progestin" class="mw-redirect" title="Progestin">progestins</a>, e.g., <a href="/wiki/Chlormadinone_acetate" title="Chlormadinone acetate">chlormadinone acetate</a>, <a href="/wiki/Cyproterone_acetate" title="Cyproterone acetate">cyproterone acetate</a>, <a href="/wiki/Hydroxyprogesterone_caproate" title="Hydroxyprogesterone caproate">hydroxyprogesterone caproate</a>, <a href="/wiki/Gestonorone_caproate" title="Gestonorone caproate">gestonorone caproate</a>, <a href="/wiki/Medroxyprogesterone_acetate" title="Medroxyprogesterone acetate">medroxyprogesterone acetate</a>, <a href="/wiki/Megestrol_acetate" title="Megestrol acetate">megestrol acetate</a>)</li></ul> <ul><li><i>Others (mixed or unknown mechanism of action):</i> <a href="/wiki/Danazol" title="Danazol">Danazol</a></li> <li><a href="/wiki/Gestrinone" title="Gestrinone">Gestrinone</a></li> <li><a href="/wiki/Metallibure" title="Metallibure">Metallibure</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-even hlist" style="width:100%;padding:0;background:#DDDDFF;"><div style="padding:0 0.25em"><div class="hlist"> <ul><li><sup>#</sup><a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">WHO-EM</a></li> <li><sup>‡</sup><a href="/wiki/List_of_withdrawn_drugs" title="List of withdrawn drugs">Withdrawn</a> from market</li> <li><a href="/wiki/Clinical_trial" title="Clinical trial">Clinical trials</a>: <ul><li><sup>†</sup><a href="/wiki/Phases_of_clinical_research#Phase_III" title="Phases of clinical research">Phase III</a></li> <li><sup>§</sup>Never to phase III</li></ul></li></ul> </div> <dl><dt>See also</dt> <dd><a href="/wiki/Template:GnRH_and_gonadotropin_receptor_modulators" title="Template:GnRH and gonadotropin receptor modulators"><abbr title="gonadotropin-releasing hormone">GnRH</abbr> and gonadotropin receptor modulators</a></dd> <dd><a href="/wiki/Template:Androgens_and_antiandrogens" title="Template:Androgens and antiandrogens">Androgens and antiandrogens</a></dd> <dd><a href="/wiki/Template:Estrogens_and_antiestrogens" title="Template:Estrogens and antiestrogens">Estrogens and antiestrogens</a></dd> <dd><a href="/wiki/Template:Progestogens_and_antiprogestogens" title="Template:Progestogens and antiprogestogens">Progestogens and antiprogestogens</a></dd></dl></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="GnRHTooltip_Gonadotropin-releasing_hormone_receptor_and_gonadotropin_receptor_modulators968" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:GnRH_and_gonadotropin_receptor_modulators" title="Template:GnRH and gonadotropin receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:GnRH_and_gonadotropin_receptor_modulators" title="Template talk:GnRH and gonadotropin receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:GnRH_and_gonadotropin_receptor_modulators" title="Special:EditPage/Template:GnRH and gonadotropin receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="GnRHTooltip_Gonadotropin-releasing_hormone_receptor_and_gonadotropin_receptor_modulators968" style="font-size:114%;margin:0 4em"><a href="/wiki/Gonadotropin-releasing_hormone_receptor" title="Gonadotropin-releasing hormone receptor"><abbr title="Gonadotropin-releasing hormone receptor">GnRH</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Gonadotropin-releasing hormone receptor</span> and <a href="/wiki/Gonadotropin_receptor" title="Gonadotropin receptor">gonadotropin receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Gonadotropin-releasing_hormone_receptor" title="Gonadotropin-releasing hormone receptor"><abbr title="Gonadotropin-releasing hormone receptor">GnRH</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Gonadotropin-releasing hormone receptor</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <i>Peptides:</i> <a href="/w/index.php?title=Alarelin&action=edit&redlink=1" class="new" title="Alarelin (page does not exist)">Alarelin</a></li> <li><a href="/w/index.php?title=Avorelin&action=edit&redlink=1" class="new" title="Avorelin (page does not exist)">Avorelin</a></li> <li><a href="/wiki/Azagly-nafarelin" title="Azagly-nafarelin">Azagly-nafarelin</a></li> <li><a href="/wiki/Buserelin" title="Buserelin">Buserelin</a></li> <li><a href="/wiki/Deslorelin" title="Deslorelin">Deslorelin</a></li> <li><a href="/wiki/Fertirelin" title="Fertirelin">Fertirelin</a></li> <li><a href="/wiki/Gonadotropin-releasing_hormone" title="Gonadotropin-releasing hormone">GnRH</a></li> <li><a href="/wiki/Gonadorelin" title="Gonadorelin">Gonadorelin</a></li> <li><a href="/wiki/Goserelin" title="Goserelin">Goserelin</a></li> <li><a href="/wiki/Histrelin" title="Histrelin">Histrelin</a></li> <li><a href="/wiki/Leuprorelin" title="Leuprorelin">Leuprorelin (leuprolide)</a></li> <li><a href="/w/index.php?title=Lutrelin&action=edit&redlink=1" class="new" title="Lutrelin (page does not exist)">Lutrelin</a></li> <li><a href="/wiki/Nafarelin" title="Nafarelin">Nafarelin</a></li> <li><a href="/wiki/Peforelin" title="Peforelin">Peforelin</a></li> <li><a href="/w/index.php?title=Salmon_GnRH&action=edit&redlink=1" class="new" title="Salmon GnRH (page does not exist)">Salmon GnRH</a></li> <li><a href="/wiki/Triptorelin" title="Triptorelin">Triptorelin</a></li> <li><a href="/w/index.php?title=Zoptarelin&action=edit&redlink=1" class="new" title="Zoptarelin (page does not exist)">Zoptarelin</a></li> <li><a href="/wiki/Zoptarelin_doxorubicin" title="Zoptarelin doxorubicin">Zoptarelin doxorubicin</a></li></ul> <ul><li><i>Antagonists:</i> <i>Peptides:</i> <a class="mw-selflink selflink">Abarelix</a></li> <li><a href="/wiki/Acyline" title="Acyline">Acyline</a></li> <li><a href="/w/index.php?title=Azaline_B&action=edit&redlink=1" class="new" title="Azaline B (page does not exist)">Azaline B</a></li> <li><a href="/wiki/Cetrorelix" title="Cetrorelix">Cetrorelix</a></li> <li><a href="/wiki/Degarelix" title="Degarelix">Degarelix</a></li> <li><a href="/w/index.php?title=Detirelix&action=edit&redlink=1" class="new" title="Detirelix (page does not exist)">Detirelix</a></li> <li><a href="/wiki/Ganirelix" title="Ganirelix">Ganirelix</a></li> <li><a href="/w/index.php?title=Iturelix&action=edit&redlink=1" class="new" title="Iturelix (page does not exist)">Iturelix (antide)</a></li> <li><a href="/w/index.php?title=LXT-101&action=edit&redlink=1" class="new" title="LXT-101 (page does not exist)">LXT-101</a></li> <li><a href="/w/index.php?title=Ornirelix&action=edit&redlink=1" class="new" title="Ornirelix (page does not exist)">Ornirelix (ornitide)</a></li> <li><a href="/wiki/Ozarelix" title="Ozarelix">Ozarelix</a></li> <li><a href="/w/index.php?title=Prazarelix&action=edit&redlink=1" class="new" title="Prazarelix (page does not exist)">Prazarelix</a></li> <li><a href="/w/index.php?title=Ramorelix&action=edit&redlink=1" class="new" title="Ramorelix (page does not exist)">Ramorelix</a></li> <li><a href="/w/index.php?title=Teverelix&action=edit&redlink=1" class="new" title="Teverelix (page does not exist)">Teverelix (antarelix)</a>; <i>Non-peptides:</i> <a href="/wiki/Elagolix" title="Elagolix">Elagolix</a></li> <li><a href="/wiki/Linzagolix" title="Linzagolix">Linzagolix</a></li> <li><a href="/wiki/Merigolix" title="Merigolix">Merigolix</a></li> <li><a href="/wiki/Opigolix" title="Opigolix">Opigolix</a></li> <li><a href="/wiki/Relugolix" title="Relugolix">Relugolix</a></li> <li><a href="/wiki/Sufugolix" title="Sufugolix">Sufugolix</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Gonadotropin_receptor" title="Gonadotropin receptor">Gonadotropin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Luteinizing_hormone/choriogonadotropin_receptor" title="Luteinizing hormone/choriogonadotropin receptor"><abbr title="Luteinizing hormone/choriogonadotropin receptor">LH/hCG</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Luteinizing hormone/choriogonadotropin receptor</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <i>Peptides:</i> <a href="/wiki/Choriogonadotropin_alfa" class="mw-redirect" title="Choriogonadotropin alfa">Choriogonadotropin alfa</a></li> <li><a href="/wiki/Human_chorionic_gonadotropin" title="Human chorionic gonadotropin">Human chorionic gonadotropin</a></li> <li><a href="/wiki/Luteinizing_hormone" title="Luteinizing hormone">Luteinizing hormone</a></li> <li><a href="/wiki/Lutropin_alfa" class="mw-redirect" title="Lutropin alfa">Lutropin alfa</a></li> <li><a href="/wiki/Menotropin" title="Menotropin">Menotropin (human menopausal gonadotropin)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Follicle-stimulating_hormone_receptor" title="Follicle-stimulating hormone receptor"><abbr title="Follicle-stimulating hormone receptor">FSH</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Follicle-stimulating hormone receptor</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <i>Peptides:</i> <a href="/wiki/Corifollitropin_alfa" class="mw-redirect" title="Corifollitropin alfa">Corifollitropin alfa</a></li> <li><a href="/wiki/Follicle-stimulating_hormone" title="Follicle-stimulating hormone">Follicle-stimulating hormone</a></li> <li><a href="/wiki/Follitropin_alfa" class="mw-redirect" title="Follitropin alfa">Follitropin alfa</a></li> <li><a href="/wiki/Follitropin_beta" class="mw-redirect" title="Follitropin beta">Follitropin beta</a></li> <li><a href="/w/index.php?title=Follitropin_epsilon&action=edit&redlink=1" class="new" title="Follitropin epsilon (page does not exist)">Follitropin epsilon</a></li> <li><a href="/wiki/Menotropin" title="Menotropin">Menotropin (human menopausal gonadotropin)</a></li> <li><a href="/wiki/Urofollitropin" title="Urofollitropin">Urofollitropin</a></li> <li><a href="/w/index.php?title=Varfollitropin_alfa&action=edit&redlink=1" class="new" title="Varfollitropin alfa (page does not exist)">Varfollitropin alfa</a></li></ul> <ul><li><i><abbr title="negative allosteric modulators">NAMs</abbr>:</i> <i>Non-peptides:</i> <a href="/w/index.php?title=ADX-61623&action=edit&redlink=1" class="new" title="ADX-61623 (page does not exist)">ADX-61623</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <p><br /> </p> <style data-mw-deduplicate="TemplateStyles:r1271159938">.mw-parser-output .asbox{position:relative;overflow:hidden}.mw-parser-output .asbox table{background:transparent}.mw-parser-output .asbox p{margin:0}.mw-parser-output .asbox p+p{margin-top:0.25em}.mw-parser-output .asbox-body{font-style:italic}.mw-parser-output .asbox-note{font-size:smaller}.mw-parser-output .asbox .navbar{position:absolute;top:-0.75em;right:1em;display:none}.mw-parser-output :not(p):not(.asbox)+style+.asbox,.mw-parser-output :not(p):not(.asbox)+link+.asbox{margin-top:3em}</style><div role="note" class="metadata plainlinks asbox stub"><table role="presentation"><tbody><tr class="noresize"><td><span typeof="mw:File"><a href="/wiki/File:Emoji_u1f48a.svg" class="mw-file-description"><img alt="Stub icon" 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