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Conference Day 2 2024 - Peptide Based Therapeutics Summit
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</div> </div> <div class="fl-col-group fl-node-5cf92206cc4d8" data-node="5cf92206cc4d8"> <div class="fl-col fl-node-5cf92206cc5c2 fl-col-bg-color" data-node="5cf92206cc5c2"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-5ba1fe150afaa fl-visible-desktop fl-visible-large fl-visible-medium" data-node="5ba1fe150afaa"> <div class="fl-module-content fl-node-content"> <h3 class="fl-heading"> <span class="fl-heading-text">April 1-3, 2025 | Boston, MA</span> </h3> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-gjw0a31drlho" data-node="gjw0a31drlho"> <div class="fl-col fl-node-rxcomvf1k4te fl-col-bg-color" data-node="rxcomvf1k4te"> <div class="fl-col-content fl-node-content"></div> </div> </div> <div class="fl-col-group fl-node-pe4tsbjlv9wu" data-node="pe4tsbjlv9wu"> <div class="fl-col fl-node-8ofxba7ecs9v fl-col-bg-color" data-node="8ofxba7ecs9v"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-button 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fl-builder-content-1242 fl-builder-content-primary fl-builder-global-templates-locked" data-post-id="1242"><div class="fl-row fl-row-fixed-width fl-row-bg-none fl-node-azrvluck68fd fl-row-default-height fl-row-align-center" data-node="azrvluck68fd"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-avl46kyjfn1e" data-node="avl46kyjfn1e"> <div class="fl-col fl-node-azuf7b10cplw fl-col-bg-color fl-col-small" data-node="azuf7b10cplw"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-link fl-node-3x0nh1pmk8rf" data-node="3x0nh1pmk8rf"> <div class="fl-module-content fl-node-content"> <a href="https://peptide-based-therapeutics-summit.com/about/agenda/day-one/" id="ee-link-3x0nh1pmk8rf"> <div class="eehw-link"> <div class="link-url"> <h2>Day One</h2> </div> <div class="link-date"> <p>Wednesday April 24 </p> </div> </div> </a> </div> </div> </div> </div> <div class="fl-col fl-node-4169ns7xipew fl-col-bg-color fl-col-small" data-node="4169ns7xipew"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-link fl-node-i9lcrxk2p3ha" data-node="i9lcrxk2p3ha"> <div class="fl-module-content fl-node-content"> <a href="https://peptide-based-therapeutics-summit.com/about/agenda/day-two/" id="ee-link-i9lcrxk2p3ha"> <div class="eehw-link"> <div class="link-url"> <h2>Day Two</h2> </div> <div class="link-date"> <p>Thursday April 25</p> </div> </div> </a> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-jfp2mvgizbn6" data-node="jfp2mvgizbn6"> <div class="fl-col fl-node-uhqvb8rf5ipt fl-col-bg-color" data-node="uhqvb8rf5ipt"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-rfk2sixqm9a1" data-node="rfk2sixqm9a1"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 8:55 am </span> Chair’s Opening Remarks </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: #cee1e9"> <h3> <span class="time"> </span> <b><center><span style="color:#242F73">Peptide-Drug Conjugates for Challenging Targets in Advanced Cancer Therapies</b></center></span> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 9:00 am </span> Exploring CBX-12-101: a First-in-Human Study of CBX-12, an AlphalexTM Peptide Drug Conjugate (PDC) in Patients With Advanced or Metastatic Solid Tumors </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://peptide-based-therapeutics-summit.com/speakers/#speaker22106" class="view-speaker" speaker-id="22106"><span>Michael Needle</span></a></em> Chief Medical Officer, Cybrexa </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• AlphalexTM peptides undergo a conformational change in acidic environments facilitating targeted delivery of highly potent anti-cancer therapeutics</p> <p>• Cybrexa PDCs do not require expression of any cell surface proteins</p> <p>• Analyzing the activity seen with 3 different schedules in multiple tumor types</p> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 9:30 am </span> Discovery & Optimization of Novel Cyclic Peptides for Precise Delivery of Pb-212-Based Targeted Alpha-Particle Therapy </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://peptide-based-therapeutics-summit.com/speakers/#speaker22107" class="view-speaker" speaker-id="22107"><span>Mengshi Li</span></a></em> Director of Pipeline Discovery, Perspective Therapeutics </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Pb-212 and Pb-203 theranostic radioisotopes</p> <p>• Discovery and optimization of cyclic peptides for Pb-212 based radiopharmaceuticals</p> <p>• Review key preclinical evaluation studies</p> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 10:00 am </span> Bicycle Radionuclide Conjugates for precision targeting of solid tumors </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://peptide-based-therapeutics-summit.com/speakers/#speaker22435" class="view-speaker" speaker-id="22435"><span>Kevin McDonnell</span></a></em> Vice President - Chemistry, Bicycle Therapeutics </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Bicycle® molecules are a novel peptide-based modality consisting of constrained peptides that form a bi-cyclic structure via ligation to a chemical scaffold and which are discovered using the Bicycle® phage display platform and have potential broad utility, allowing efficient and targeted delivery of different classes of payloads into tumors.</li> <li>We are developing Bicycle Radionuclide Conjugates (BRC™ molecules), in which Bicycle® molecules are employed as targeting vectors to deliver radioisotopes to tumors for cancer imaging and therapy.</li> <li>Bicycle® molecules exhibit properties that make them an ideal modality for radionuclide delivery. They can achieve exquisite binding specificity and high binding affinity and have demonstrated rapid tumor penetration, resulting in high accumulation of payload in the tumor but with limited exposure to normal tissues.</li> <li>We have used in vitro cell binding assays and mouse cell line derived xenograft models to characterize early MT1 targeted BRC™ molecules to establish binding properties and in vivo biodistribution and demonstrated that —BRC™ molecules can be chemically optimized to improve their in vivo biodistribution profiles.</li> </ul> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 10:30 am </span> <b><span style="color:#38ACE1">Morning Break & Networking</b></span> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: #cee1e9"> <h3> <span class="time"> </span> <b><center><span style="color:#242F73">Evolving Peptide ADME Properties for Enhancing Their Therapeutic Success</b></center></span> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 11:30 am </span> Optimizing Peptide Properties for Targeted Protein Degradation With High Specificity </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://peptide-based-therapeutics-summit.com/speakers/#speaker22108" class="view-speaker" speaker-id="22108"><span>Jakob Fuhrmann</span></a></em> Senior Principal Scientist EDB, Genentech </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Reviewing next-generation designs for developing peptides as protein degraders</p> <p>• Bridging the gap between glues and heterobifunctional degraders</p> <p>• Addressing peptide-specific challenges within medicinal chemistry such as cell permeability and stability</p> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 12:00 pm </span> Delving into 2-Pyridine Carboxaldehyde Derivatization for Cyclic Peptide Soft Spot ID & Improved Stability </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://peptide-based-therapeutics-summit.com/speakers/#speaker22109" class="view-speaker" speaker-id="22109"><span>Joe Cannon</span></a></em> Scientific Associate Director, Biotransformation, Bristol Myers Squibb </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Utilization of N-terminal selectivity for simple identification of soft spots from in vitro matrices</p> <p>• Tag optimization for increased sensitivity and longer simple N-terminal sequence tags</p> <p>• Transfer to ex vivo matrices from PK screening</p> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 12:30 pm </span> <b><span style="color:#38ACE1">Lunch</b></span> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: #cee1e9"> <h3> <span class="time"> </span> <b><center><span style="color:#242F73">Improving Peptide Oral Bioavailability to Open Up New Treatment Avenues</b></center></span> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 1:30 pm </span> Leveraging Advances In Permeation Enhancers to Reach New Levels Of Bioavailability </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://peptide-based-therapeutics-summit.com/speakers/#speaker22111" class="view-speaker" speaker-id="22111"><span>David Brayden</span></a></em> Associate Professor & Director - Advanced Drug Delivery, University College Dublin </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Maximizing bioavailability when combining permeation enhancers with a high-potency peptide</p> <p>• Selecting the optimal permeation enhancer to use alongside a therapeutic peptide</p> <p>• Highlighting the latest permeation enhancer updates and mechanisms</p> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 2:00 pm </span> Leveraging Macrocyclic Peptides to Achieve Novel MOAs and High Specificity Against Intracellular Targets </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://peptide-based-therapeutics-summit.com/speakers/#speaker22112" class="view-speaker" speaker-id="22112"><span>Joshua Schwochert</span></a></em> CSO, Unnatural Products </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Extensive scaffold hopping and physicochemical property tuning of display technology hits.</li> <li>Generation of compounds with low and sub pM affinities and potent cell activity. </li> <li>Exploration of Unnatural Product’s parallel synthesis and computational design platform</li> </ul> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: #cee1e9"> <h3> <span class="time"> </span> <b><center><span style="color:#242F73">Streamlining the Process of Moving Peptide Based Therapeutics Into The Clinic & Beyond</b></center></span> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 2:30 pm </span> Photochemically-Enabled, Post-Translational Production of Therapeutic C-Terminal Amides” </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://peptide-based-therapeutics-summit.com/speakers/#speaker22441" class="view-speaker" speaker-id="22441"><span>David Hymel</span></a></em> Principal Research Scientist, Novo Nordisk </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>We have developed chemistry to convert recombinantly expressed peptides containing a C-terminal cysteine extension to a therapeutically relevant C-terminal amide via photochemical decomposition of the corresponding arylated cysteine thiol</li> <li>The process is robust, high-yielding, amenable to UV- or visible-light conditions, and is broadly applicable to all natural amino acid side chains at the C-terminus. We also demonstrate the applicability to a range of biologically relevant peptides</li> <li> Finally, we show that the photochemical process is amenable to flow-based methods at gram and decagram scale, indicating potential applicability to CMC processes alongside current methodologies dependent on resource intensive expression methods such as PAM enzyme</li> </ul> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 3:00 pm </span> Chair’s Closing Remarks </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> </div> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-u240vkeognbt" data-node="u240vkeognbt"> <div class="fl-col fl-node-tz6k9aumfysd fl-col-bg-color fl-col-small" data-node="tz6k9aumfysd"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-button 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mouseleave');this._menuOnClick();this._clickOrHover();}else{$(this.wrapperClass).off('click');this._submenuOnRight();this._submenuRowZindexFix();} if(this.mobileToggle!='expanded'){this._toggleForMobile();} if($(this.wrapperClass).find('.fl-menu-search-item').length){this._toggleMenuSearch();} if($(this.wrapperClass).find('.fl-menu-cart-item').length){this._wooUpdateParams();}},_setupSubmenu:function(){$(this.wrapperClass+' ul.sub-menu').each(function(){$(this).closest('li').attr('aria-haspopup','true');});},_menuOnFocus:function(){var cKey=0,isShifted=false;$(this.nodeClass).off('keydown').on('keydown','a',function(e){cKey=e.which;isShifted=e.shiftKey;});$(this.nodeClass).off('focus').on('focus','a',$.proxy(function(e){var $menuItem=$(e.target).parents('.menu-item').first(),$parents=$(e.target).parentsUntil(this.wrapperClass);$('.fl-menu .focus').removeClass('focus');$parents.addClass('focus') if(!$menuItem.closest('.fl-has-submenu').hasClass('escaped')){$menuItem.addClass('focus')} else{$menuItem.closest('.fl-has-submenu').removeClass('focus escaped')}},this)).on('focusout','a',$.proxy(function(e){var el=$(e.target).parent(),$megaMenu=el.closest('.mega-menu'),$megaLastItem=$megaMenu.find('> .sub-menu > .menu-item:last-child'),$lastItem=el.parents('.fl-has-submenu:last').find('.menu-item:last'),isLastChild=!$megaMenu.length&&el.is($lastItem);if($megaMenu.length){isLastChild=el.is($megaLastItem)||el.is($megaLastItem.find('.menu-item:last-child'));} if(isLastChild&&cKey===9&&isShifted){isLastChild=false;cKey=0;isShifted=false;} else if(cKey===27){isLastChild=false;} if(isLastChild){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_menuOnEscape:function(){$('body').off('keydown').on('keydown',$.proxy(function(e){if(e.which!==27){return;} if($(e.target).closest('.menu-item').length){var activeSubmenu=null,menuItem=$(e.target).closest('.menu-item'),type=menuItem.closest('.fl-menu-accordion').length?'accordion':'horizontal';if('horizontal'===type){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('focus')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.parent().addClass('escaped');activeSubmenu.parent().find('a:first').focus();} else{if(menuItem.hasClass('fl-has-submenu')&&'accordion'===type&&menuItem.hasClass('fl-active')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.slideUp(400,function(){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('fl-active')){activeSubmenu.parent().last().find('a:first').focus();} else{menuItem.removeClass('focus');menuItem.parents('.menu-item').first().find('a:first').focus();} activeSubmenu.parent().last().removeClass('fl-active');});}} else{$('.fl-menu').find('li.menu-item.focus').last().removeClass('focus');}},this));},_menuOnClick:function(){$(this.wrapperClass).off().on('click','.fl-has-submenu-container',$.proxy(function(e){var $link=$(e.target).parents('.fl-has-submenu').first(),$subMenu=$link.children('.sub-menu').first(),$href=$link.children('.fl-has-submenu-container').first().find('> a').attr('href'),$subMenuParents=$(e.target).parents('.sub-menu'),$activeParents=$(e.target).parents('.fl-has-submenu.fl-active');if(!$subMenu.is(':visible')||$(e.target).hasClass('fl-menu-toggle')||($subMenu.is(':visible')&&(typeof $href==='undefined'||$href=='#'))){e.preventDefault();} else{e.stopPropagation();window.location.href=$href;return;} if($(this.wrapperClass).hasClass('fl-menu-accordion-collapse')){if(!$link.parents('.menu-item').hasClass('fl-active')){$('.menu .fl-active',this.wrapperClass).not($link).removeClass('fl-active');} else if($link.parents('.menu-item').hasClass('fl-active')&&$link.parent('.sub-menu').length){$('.menu .fl-active',this.wrapperClass).not($link).not($activeParents).removeClass('fl-active');} $('.sub-menu',this.wrapperClass).not($subMenu).not($subMenuParents).slideUp('normal');} if(!this.mobileStacked&&'horizontal'==this.type&&'expanded'==this.mobileToggle){$(this.wrapperClass).find('.fl-active').not($link).not($activeParents).removeClass('fl-active');} else{$subMenu.slideToggle();} $link.toggleClass('fl-active');e.stopPropagation();},this));},_submenuOnClick:function(){$(this.wrapperClass+' .sub-menu').off().on('click','a',$.proxy(function(e){if($(e.target).parent().hasClass('focus')){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_clickOrHover:function(){this.$submenus=this.$submenus||$(this.wrapperClass).find('.sub-menu');var $wrapper=$(this.wrapperClass),$menu=$wrapper.find('.menu');$li=$wrapper.find('.fl-has-submenu');if(this._isMenuToggle()){$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').fadeOut();}});}else{$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').css({'display':'','opacity':''});}});}},_submenuOnRight:function(){$(this.wrapperClass).on('mouseenter focus','.fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} var $link=$(e.currentTarget),$parent=$link.parent(),$subMenu=$link.find('.sub-menu'),subMenuWidth=$subMenu.width(),subMenuPos=0,bodyWidth=$('body').width();if($link.closest('.fl-menu-submenu-right').length!==0){$link.addClass('fl-menu-submenu-right');}else if($('body').hasClass('rtl')){subMenuPos=$parent.is('.sub-menu')?$parent.offset().left-subMenuWidth:$link.offset().left-$link.width()-subMenuWidth;if(subMenuPos<=0){$link.addClass('fl-menu-submenu-right');}}else{subMenuPos=$parent.is('.sub-menu')?$parent.offset().left+$parent.width()+subMenuWidth:$link.offset().left+$link.width()+subMenuWidth;if(subMenuPos>bodyWidth){$link.addClass('fl-menu-submenu-right');}}},this)).on('mouseleave','.fl-has-submenu',$.proxy(function(e){$(e.currentTarget).removeClass('fl-menu-submenu-right');},this));},_submenuRowZindexFix:function(e){$(this.wrapperClass).on('mouseenter','ul.menu > .fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} $(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','10');},this)).on('mouseleave','ul.menu > .fl-has-submenu',$.proxy(function(e){$(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','');},this));},_toggleForMobile:function(){var $wrapper=null,$menu=null,self=this;if(this._isMenuToggle()){if(this._isMobileBelowRowEnabled()){this._placeMobileMenuBelowRow();$wrapper=$(this.wrapperClass);$menu=$(this.nodeClass+'-clone');$menu.find('ul.menu').show();} else{$wrapper=$(this.wrapperClass);$menu=$wrapper.find('.menu');} if(!$wrapper.find('.fl-menu-mobile-toggle').hasClass('fl-active')&&!self.mobileFlyout){$menu.css({display:'none'});} if(self.mobileFlyout){this._initFlyoutMenu();} $wrapper.on('click','.fl-menu-mobile-toggle',function(e){$(this).toggleClass('fl-active');if(self.mobileFlyout){self._toggleFlyoutMenu();} else{var targetMenu=null;if(self.mobileBelowRow){targetMenu=$(this).closest('.fl-col').next('.fl-menu-mobile-clone');}else{targetMenu=$(this).closest('.fl-menu').find('ul.menu');} if(targetMenu.length){$menu=$(targetMenu);} $menu.slideToggle();} e.stopPropagation();});$menu.off().on('click','.menu-item > a[href*="#"]:not([href="#"])',function(e){var $href=$(this).attr('href'),$targetID=$href.split('#')[1],element=$('#'+$targetID);if($('body').find(element).length>0){$(this).toggleClass('fl-active');FLBuilderLayout._scrollToElement(element);if(!self._isMenuToggle()){$menu.slideToggle();}}});} else{if(this._isMobileBelowRowEnabled()){this._removeMenuFromBelowRow();} $wrapper=$(this.wrapperClass),$menu=$wrapper.find('ul.menu');$wrapper.find('.fl-menu-mobile-toggle').removeClass('fl-active');$menu.css({display:''});if(!this._isMobileBelowRowEnabled()){$menu.off('click','.menu-item > a[href*="#"]:not([href="#"])');} if(this.mobileFlyout&&$wrapper.find('.fl-menu-mobile-flyout').length>0){$('body').css('margin','');$('.fl-builder-ui-pinned-content-transform').css('transform','');$menu.unwrap();$wrapper.find('.fl-menu-mobile-close').remove();$wrapper.find('.fl-menu-mobile-opacity').remove();}}},_initMegaMenus:function(){var module=$(this.nodeClass),rowContent=module.closest('.fl-row-content'),rowWidth=rowContent.width(),megas=module.find('.mega-menu'),disabled=module.find('.mega-menu-disabled'),isToggle=this._isMenuToggle();if(isToggle){megas.removeClass('mega-menu').addClass('mega-menu-disabled');module.find('li.mega-menu-disabled > ul.sub-menu').css('width','');rowContent.css('position','');}else{disabled.removeClass('mega-menu-disabled').addClass('mega-menu');module.find('li.mega-menu > ul.sub-menu').css('width',rowWidth+'px');rowContent.css('position','relative');}},_isMobileBelowRowEnabled:function(){return this.mobileBelowRow&&$(this.nodeClass).closest('.fl-col').length;},_placeMobileMenuBelowRow:function(){if($(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=null,col=module.closest('.fl-col');if(module.length<1){return;} clone=(module.length>1)?$(module[0]).clone():module.clone();module.find('ul.menu').remove();clone.addClass((this.nodeClass+'-clone').replace('.',''));clone.addClass('fl-menu-mobile-clone');clone.find('.fl-menu-mobile-toggle').remove();col.after(clone);if(module.hasClass('fl-animation')){clone.removeClass('fl-animation');} this._menuOnClick();},_removeMenuFromBelowRow:function(){if(!$(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=$(this.nodeClass+'-clone'),menu=clone.find('ul.menu');module.find('.fl-menu-mobile-toggle').after(menu);clone.remove();menu.find('a').each(FLBuilderLayout._initAnchorLink);},_initFlyoutMenu:function(){var win=$(window),wrapper=$(this.wrapperClass),menu=wrapper.find('ul.menu'),button=wrapper.find('.fl-menu-mobile-toggle');if(0===wrapper.find('.fl-menu-mobile-flyout').length){menu.wrap('<div class="fl-menu-mobile-flyout"></div>');} if(0===wrapper.find('.fl-menu-mobile-close').length){close=window.fl_responsive_close||'Close' wrapper.find('.fl-menu-mobile-flyout').prepend('<button class="fl-menu-mobile-close" aria-label="'+close+'"><i class="fas fa-times" aria-hidden="true"></i></button>');} if(wrapper.hasClass('fl-menu-responsive-flyout-push-opacity')&&0===wrapper.find('.fl-menu-mobile-opacity').length){wrapper.append('<div class="fl-menu-mobile-opacity"></div>');} wrapper.on('click','.fl-menu-mobile-opacity, .fl-menu-mobile-close',function(e){button.trigger('click');e.stopPropagation();});if('undefined'!==typeof FLBuilder){FLBuilder.addHook('restartEditingSession',function(){$('.fl-builder-ui-pinned-content-transform').css('transform','');if(button.hasClass('fl-active')){button.trigger('click');}});}},_toggleFlyoutMenu:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),position=wrapper.hasClass('fl-flyout-right')?'right':'left',pushMenu=wrapper.hasClass('fl-menu-responsive-flyout-push')||wrapper.hasClass('fl-menu-responsive-flyout-push-opacity'),opacity=wrapper.find('.fl-menu-mobile-opacity'),marginPos={},posAttr={},fixedPos={},winHeight=$(window).height(),fixedHeader=$('header, header > div');this._resizeFlyoutMenuPanel();if($('.fl-builder-ui-pinned-content-transform').length>0&&!$('body').hasClass('fl-builder-edit')){$('.fl-builder-ui-pinned-content-transform').css('transform','none');} if(pushMenu){marginPos['margin-'+position]=button.hasClass('fl-active')?'250px':'0px';$('body').animate(marginPos,200);if(fixedHeader.length>0){fixedPos[position]=button.hasClass('fl-active')?'250px':'0px';fixedHeader.each(function(){if('fixed'==$(this).css('position')){$(this).css({'-webkit-transition':'none','-o-transition':'none','transition':'none'});$(this).animate(fixedPos,200);}});}} if(opacity.length>0&&button.hasClass('fl-active')){opacity.show();} else{opacity.hide();}},_resizeFlyoutMenuPanel:function(){const wrapper=$(this.wrapperClass);const wrapFlyout=wrapper.find('.fl-menu-mobile-flyout');if(wrapFlyout.length>0){wrapFlyout.css(this._getFlyoutMenuPanelPosition());}},_getFlyoutMenuPanelPosition:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),side=wrapper.hasClass('fl-flyout-right')?'right':'left',winHeight=$(window).outerHeight(),winTop=$(window).scrollTop(),adminBarHeight=$('#wpadminbar').length?$('#wpadminbar').height():0,flyoutPosition={};flyoutPosition[side]='-267px';if(!button.hasClass('fl-active')){return flyoutPosition;} flyoutPosition[side]='0px';flyoutPosition['height']=winHeight+'px';flyoutPosition['top']='0px';if(adminBarHeight>0){const diff=adminBarHeight-winTop;flyoutPosition['top']=diff<=0?'0px':(diff)+'px';} return flyoutPosition;},_toggleMenuSearch:function(){var wrapper=$(this.wrapperClass).find('.fl-menu-search-item'),button=wrapper.find('a.fl-button'),form=wrapper.find('.fl-search-form-input-wrap'),self=this;button.on('click',function(e){e.preventDefault();if(form.is(':visible')){form.stop().fadeOut(200);} else{form.stop().fadeIn(200);$('body').on('click.fl-menu-search',$.proxy(self._hideMenuSearch,self));form.find('.fl-search-text').focus();}});},_hideMenuSearch:function(e){var form=$(this.wrapperClass).find('.fl-search-form-input-wrap');if(e!==undefined){if($(e.target).closest('.fl-menu-search-item').length>0){return;}} form.stop().fadeOut(200);$('body').off('click.fl-menu-search');},_wooUpdateParams:function(){if('undefined'!==typeof wc_cart_fragments_params){wc_cart_fragments_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;} if('undefined'!==typeof wc_add_to_cart_params){wc_add_to_cart_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;}},};})(jQuery);;(function($){$(function(){new FLBuilderMenu({id:'5cb735f42d5d2',type:'horizontal',mobile:'text',mobileBelowRow:true,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'medium-mobile',postId:'54',mobileStacked:true,});});})(jQuery);;(function($){$(function(){new FLBuilderMenu({id:'5cf92200ec99d',type:'accordion',mobile:'hamburger',mobileBelowRow:false,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'always',postId:'54',mobileStacked:true,});});})(jQuery);;jQuery(function($){$(function(){$('.fl-node-5cf92200ec9a1 .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;jQuery(function($){$(function(){$('.fl-node-8da502y39tlv .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;;(function($){FLThemeBuilderHeaderLayout={win:null,body:null,header:null,overlay:false,hasAdminBar:false,stickyOn:'',breakpointWidth:0,init:function(){var editing=$('html.fl-builder-edit').length,header=$('.fl-builder-content[data-type=header]'),menuModule=header.find('.fl-module-menu'),breakpoint=null;if(!editing&&header.length){header.imagesLoaded($.proxy(function(){this.win=$(window);this.body=$('body');this.header=header.eq(0);this.overlay=!!Number(header.attr('data-overlay'));this.hasAdminBar=!!$('body.admin-bar').length;this.stickyOn=this.header.data('sticky-on');breakpoint=this.header.data('sticky-breakpoint');if(''==this.stickyOn){if(typeof FLBuilderLayoutConfig.breakpoints[breakpoint]!==undefined){this.breakpointWidth=FLBuilderLayoutConfig.breakpoints[breakpoint];} else{this.breakpointWidth=FLBuilderLayoutConfig.breakpoints.medium;}} if(Number(header.attr('data-sticky'))){this.header.data('original-top',this.header.offset().top);this.win.on('resize',$.throttle(500,$.proxy(this._initSticky,this)));this._initSticky();}},this));}},_initSticky:function(e){var header=$('.fl-builder-content[data-type=header]'),windowSize=this.win.width(),makeSticky=false;makeSticky=this._makeWindowSticky(windowSize);if(makeSticky||(this.breakpointWidth>0&&windowSize>=this.breakpointWidth)){this.win.on('scroll.fl-theme-builder-header-sticky',$.proxy(this._doSticky,this));if(e&&'resize'===e.type){if(this.header.hasClass('fl-theme-builder-header-sticky')){this._doSticky(e);} this._adjustStickyHeaderWidth();} if(Number(header.attr('data-shrink'))){this.header.data('original-height',this.header.outerHeight());this.win.on('resize',$.throttle(500,$.proxy(this._initShrink,this)));this._initShrink();} this._initFlyoutMenuFix(e);}else{this.win.off('scroll.fl-theme-builder-header-sticky');this.win.off('resize.fl-theme-builder-header-sticky');this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');}},_makeWindowSticky:function(windowSize){var makeSticky=false;switch(this.stickyOn){case'xl':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['large'];break;case'':case'desktop':makeSticky=windowSize>=FLBuilderLayoutConfig.breakpoints['medium'];break;case'desktop-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small'];break;case'large':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['medium']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'large-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'medium':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']&&windowSize>FLBuilderLayoutConfig.breakpoints['small']);break;case'medium-mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']);break;case'mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['small']);break;case'all':makeSticky=true;break;} return makeSticky;},_doSticky:function(e){var winTop=Math.floor(this.win.scrollTop()),headerTop=Math.floor(this.header.data('original-top')),hasStickyClass=this.header.hasClass('fl-theme-builder-header-sticky'),hasScrolledClass=this.header.hasClass('fl-theme-builder-header-scrolled'),beforeHeader=this.header.prevAll('.fl-builder-content'),bodyTopPadding=parseInt(jQuery('body').css('padding-top')),winBarHeight=$('#wpadminbar').length?$('#wpadminbar').outerHeight():0,headerHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(this.hasAdminBar&&this.win.width()>600){winTop+=Math.floor(winBarHeight);} if(winTop>headerTop){if(!hasStickyClass){if(e&&('scroll'===e.type||'smartscroll'===e.type)){this.header.addClass('fl-theme-builder-header-sticky');if(this.overlay&&beforeHeader.length){this.header.css('top',winBarHeight);}} if(!this.overlay){this._adjustHeaderHeight();}}} else if(hasStickyClass){this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');} this._adjustStickyHeaderWidth();if(winTop>headerTop){if(!hasScrolledClass){this.header.addClass('fl-theme-builder-header-scrolled');}}else if(hasScrolledClass){this.header.removeClass('fl-theme-builder-header-scrolled');} this._flyoutMenuFix(e);},_initFlyoutMenuFix:function(e){var header=this.header,menuModule=header.closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),isPushMenu=menuModule.hasClass('fl-menu-responsive-flyout-push')||menuModule.hasClass('fl-menu-responsive-flyout-push-opacity'),isOverlay=menuModule.hasClass('fl-menu-responsive-flyout-overlay'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',flyoutParent=header.parent().is('header')?header.parent().parent():header.parent();isFullWidth=this.win.width()===header.width(),flyoutLayout='',activePos=250,headerPos=0;if(!flyoutMenu.length){return;} if(this.win.width()>header.parent().width()){headerPos=(this.win.width()-header.width())/ 2;} if(isOverlay){activePos=headerPos;} else if(isPushMenu){activePos=activePos+headerPos;} flyoutMenu.data('activePos',activePos);if(isPushMenu){flyoutLayout='push-'+flyoutPos;} else if(isOverlay){flyoutLayout='overlay-'+flyoutPos;} if(isPushMenu&&!$('html').hasClass('fl-theme-builder-has-flyout-menu')){$('html').addClass('fl-theme-builder-has-flyout-menu');} if(!flyoutParent.hasClass('fl-theme-builder-flyout-menu-'+flyoutLayout)){flyoutParent.addClass('fl-theme-builder-flyout-menu-'+flyoutLayout);} if(!header.hasClass('fl-theme-builder-flyout-menu-overlay')&&isOverlay){header.addClass('fl-theme-builder-flyout-menu-overlay');} if(!header.hasClass('fl-theme-builder-header-full-width')&&isFullWidth){header.addClass('fl-theme-builder-header-full-width');} else if(!isFullWidth){header.removeClass('fl-theme-builder-header-full-width');} menuModule.on('click','.fl-menu-mobile-toggle',$.proxy(function(event){if(menuModule.find('.fl-menu-mobile-toggle.fl-active').length){$('html').addClass('fl-theme-builder-flyout-menu-active');event.stopImmediatePropagation();} else{$('html').removeClass('fl-theme-builder-flyout-menu-active');} this._flyoutMenuFix(event);},this));},_flyoutMenuFix:function(e){var header=this.header,menuModule=$(e.target).closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',menuOpacity=menuModule.find('.fl-menu-mobile-opacity'),isScroll='undefined'!==typeof e&&'scroll'===e.handleObj.type,activePos='undefined'!==typeof flyoutMenu.data('activePos')?flyoutMenu.data('activePos'):0,headerPos=(this.win.width()-header.width())/ 2,inactivePos=headerPos>0?activePos+4:254;if(!flyoutMenu.length){return;} if(this.overlay){return;} if($('.fl-theme-builder-flyout-menu-active').length){if(isScroll&&!flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.addClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-header-sticky')){if(!isScroll){setTimeout($.proxy(function(){flyoutMenu.css(flyoutPos,'-'+activePos+'px');},this),1);} else{flyoutMenu.css(flyoutPos,'-'+activePos+'px');}} else{flyoutMenu.css(flyoutPos,'0px');}} else{if(flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.removeClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-flyout-menu-overlay')&&headerPos>0&&headerPos<250){if(header.hasClass('fl-theme-builder-header-sticky')){inactivePos=headerPos+254;} else{inactivePos=254;}} if(e&&e.type==='resize'){inactivePos=headerPos+254;} flyoutMenu.css(flyoutPos,'-'+inactivePos+'px');} if(e&&menuModule.is('.fl-menu-responsive-flyout-overlay')&&$.infinitescroll){e.stopImmediatePropagation();} if(menuOpacity.length){if(header.hasClass('fl-theme-builder-header-sticky')){if('0px'===menuOpacity.css('left')){menuOpacity.css('left','-'+headerPos+'px');}} else{menuOpacity.css('left','');}}},_adjustStickyHeaderWidth:function(){if($('body').hasClass('fl-fixed-width')){var parentWidth=this.header.parent().width();if(this.win.width()>=992){this.header.css({'margin':'0 auto','max-width':parentWidth,});} else{this.header.css({'margin':'','max-width':'',});}}},_adjustHeaderHeight:function(){var beforeHeader=this.header.prevAll('.fl-builder-content'),beforeHeaderHeight=0,beforeHeaderFix=0,headerHeight=Math.floor(this.header.outerHeight()),bodyTopPadding=parseInt($('body').css('padding-top')),wpAdminBarHeight=0,totalHeaderHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(beforeHeader.length){$.each(beforeHeader,function(){beforeHeaderHeight+=Math.floor($(this).outerHeight());});beforeHeaderFix=2;} 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