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class="profile--tab_heading_container">Papers by László Barna István</h3></div><div class="js-work-strip profile--work_container" data-work-id="5726707"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/5726707/Energy_Dependence_of_Multiplicity_Fluctuations_in_Heavy_Ion_Collisions"><img alt="Research paper thumbnail of Energy Dependence of Multiplicity Fluctuations in Heavy Ion Collisions" class="work-thumbnail" src="https://attachments.academia-assets.com/32764708/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/5726707/Energy_Dependence_of_Multiplicity_Fluctuations_in_Heavy_Ion_Collisions">Energy Dependence of Multiplicity Fluctuations in Heavy Ion Collisions</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The energy dependence of multiplicity fluctuations was studied for the most central Pb + Pb colli...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The energy dependence of multiplicity fluctuations was studied for the most central Pb + Pb collisions at 20A, 30A, 40A, 80A and 158A GeV by the NA49 experiment at the CERN SPS. The multiplicity distribution for negatively and positively charged hadrons is significantly narrower than Poisson one for all energies. No significant structure in energy dependence of the scaled variance of multiplicity fluctuations is observed. The measured scaled variance is lower than the one predicted by the grand-canonical formulation of the hadron-resonance gas model. The results for scaled variance are in approximate agreement with the string-hadronic model UrQMD.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ff2f83032e86437ecf56f4eda7860b57" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":32764708,"asset_id":5726707,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/32764708/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726707"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726707"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726707; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="5726706"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/5726706/Matrix_Metalloproteinase_Inhibitors_A_Critical_Appraisal_of_Design_Principles_and_Proposed_Therapeutic_Utility"><img alt="Research paper thumbnail of Matrix Metalloproteinase Inhibitors: A Critical Appraisal of Design Principles and Proposed Therapeutic Utility" class="work-thumbnail" src="https://attachments.academia-assets.com/49166329/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/5726706/Matrix_Metalloproteinase_Inhibitors_A_Critical_Appraisal_of_Design_Principles_and_Proposed_Therapeutic_Utility">Matrix Metalloproteinase Inhibitors: A Critical Appraisal of Design Principles and Proposed Therapeutic Utility</a></div><div class="wp-workCard_item"><span>Drugs</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Matrix metalloproteinases (MMPs) play an important role in tissue remodelling associated with var...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Matrix metalloproteinases (MMPs) play an important role in tissue remodelling associated with various physiological and pathological processes, such as morphogenesis, angiogenesis, tissue repair, arthritis, chronic heart failure, chronic obstructive pulmonary disease, chronic inflammation and cancer metastasis. As a result, MMPs are considered to be viable drug targets in the therapy of these diseases. Despite the high therapeutic potential of MMP inhibitors (MMPIs), all clinical trials have failed to date, except for doxycycline for periodontal disease. This can be attributed to (i) poor selectivity of the MMPIs, (ii) poor target validation for the targeted therapy and (iii) poorly defined predictive preclinical animal models for safety and efficacy. Lessons from previous failures, such as recent discoveries of oxidative/ nitrosative activation and phosphorylation of MMPs, as well as novel nonmatrix related intra-and extracellular targets of MMP, give new hope for MMPI development for both chronic and acute diseases. In this article we critically review the major structural determinants of the selectivity and the milestones of past design efforts of MMPIs where 2-/3-dimensional structurebased methods were intensively applied. We also analyse the in vitro screening and preclinical/clinical pharmacology approaches, with particular emphasis on drawing conclusions on how to overcome efficacy and safety problems through better target validation and design of preclinical studies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bbf286d1e9b183e7ae6db863912d0ada" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49166329,"asset_id":5726706,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49166329/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726706"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726706"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726706; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=5726706]").text(description); $(".js-view-count[data-work-id=5726706]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 5726706; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='5726706']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="5726705"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/5726705/HbA_1c_levels_and_erythrocyte_transport_functions_in_complication_free_type_1_diabetic_children_and_adolescents"><img alt="Research paper thumbnail of HbA 1c levels and erythrocyte transport functions in complication-free type 1 diabetic children and adolescents" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/5726705/HbA_1c_levels_and_erythrocyte_transport_functions_in_complication_free_type_1_diabetic_children_and_adolescents">HbA 1c levels and erythrocyte transport functions in complication-free type 1 diabetic children and adolescents</a></div><div class="wp-workCard_item"><span>Acta Diabetologica</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Higher erythrocyte sodium-lithium countertransport activity (SLC) is implicated in the developmen...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Higher erythrocyte sodium-lithium countertransport activity (SLC) is implicated in the development of diabetic nephropathy. Altered glucose homeostasis and genetic susceptibility are claimed to play a role in the elevation of SLC. We aimed to test whether metabolic control or the genetic variants of G protein beta 3 (Gb3) subunits determine SLC and other erythrocyte transport activities in complication-free stage of type 1 diabetes. A total of 96 complication-free type 1 diabetic children and adolescents were enrolled. SLC, Na+/K+-ATPase (NAK) and Ca2+-ATPase (CA) were measured by functional assays in erythrocytes. Gb3-C825T polymorphism was determined by PCR-RFLP. Results were related to HbA1c and were compared to those of 97 healthy controls. SLC activity was higher in diabetics (387±146 vs. 280±65 mmol/RBC · hour) and correlated with HbA1c levels (y=0.004x+6.42, r=0.33, n=96, p<0.01). NAK and CA activities were unaltered. The prevalence of 825T allele was similar in the patient and control groups (0.34 vs 0.37) and no differences in enzyme activities were observed between the 825T allele-positive and negative subjects. Although metabolic control correlated with SLC, other membrane functions were not affected. Therefore we hypothesize that the relationship between advanced glycation and SLC elevation is not causative. Rather, a genetic susceptibility for the coexistence of poor metabolic control and higher SLC is more likely. However, the presence of Gb3-C825T variant is not likely to be a risk factor for SLC-elevation and altered metabolic control diabetes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726705"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726705"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726705; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=5726705]").text(description); 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</script> <div class="js-work-strip profile--work_container" data-work-id="5726704"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/5726704/Energy_dependence_of_varphi_meson_production_in_central_Pb_Pb_collisions_at_sNN_6_to_17_GeV"><img alt="Research paper thumbnail of Energy dependence of varphi meson production in central Pb+Pb collisions at sNN=6 to 17 GeV" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/5726704/Energy_dependence_of_varphi_meson_production_in_central_Pb_Pb_collisions_at_sNN_6_to_17_GeV">Energy dependence of varphi meson production in central Pb+Pb collisions at sNN=6 to 17 GeV</a></div><div class="wp-workCard_item"><span>Physical Review C</span><span>, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726704"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726704"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726704; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=5726704]").text(description); $(".js-view-count[data-work-id=5726704]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 5726704; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='5726704']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="5726703"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/5726703/Centrality_and_system_size_dependence_of_multiplicity_fluctuations_in_nuclear_collisions_at_158A_GeV"><img alt="Research paper thumbnail of Centrality and system size dependence of multiplicity fluctuations in nuclear collisions at 158A GeV" class="work-thumbnail" src="https://attachments.academia-assets.com/49166223/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/5726703/Centrality_and_system_size_dependence_of_multiplicity_fluctuations_in_nuclear_collisions_at_158A_GeV">Centrality and system size dependence of multiplicity fluctuations in nuclear collisions at 158A GeV</a></div><div class="wp-workCard_item"><span>Physical Review C</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The centrality and system size dependence of multiplicity fluctuations of charged particles produ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The centrality and system size dependence of multiplicity fluctuations of charged particles produced in nuclear collisions at $158 A$ GeV was studied by the NA49 collaboration. Centrality selected Pb+Pb collisions, semi-central C+C and Si+Si collisions as well as inelastic p+p interactions were analyzed. The number of projectile participants determined on an event-by-event basis was used to characterize the collision centrality. The scaled variance of the multiplicity distribution obtained in the forward rapidity region ($1.1 <y_{c.m.} <2.6$) shows a significant increase towards peripheral collisions. The results are similar for negatively and positively charged particles and about 50% larger for all charged particles. String-hadronic models of nuclear reactions without the fusion process do not reproduce the rise of fluctuations from central towards peripheral collisions. The measured centrality dependence can be reproduced in superposition models with the assumption of contributions from target participants to particle production in the forward hemisphere or in string models with fusion.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="766fd2578d8510b84c18b0a8a823e58f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49166223,"asset_id":5726703,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49166223/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726703"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726703"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726703; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=5726703]").text(description); $(".js-view-count[data-work-id=5726703]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 5726703; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='5726703']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="5726702"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/5726702/Prevalence_of_symptomes_of_the_metabolic_syndrome_in_kidney_transplant_recipients"><img alt="Research paper thumbnail of Prevalence of symptomes of the metabolic syndrome in kidney transplant recipients" class="work-thumbnail" src="https://attachments.academia-assets.com/49166245/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/5726702/Prevalence_of_symptomes_of_the_metabolic_syndrome_in_kidney_transplant_recipients">Prevalence of symptomes of the metabolic syndrome in kidney transplant recipients</a></div><div class="wp-workCard_item"><span>Diabetes Research and Clinical Practice</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">patients with normoalbumimnia(NOR; ~19mg/gCr)(ptO.OOl).Moreover, 22% of patients with NOR had hig...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">patients with normoalbumimnia(NOR; ~19mg/gCr)(ptO.OOl).Moreover, 22% of patients with NOR had higher type 4 collagen levels than a normal value. U4C levels were positively correlated with UA levels in all the patients with and without nephropathy (t=O.695). On the other hand, U4C values of non-diabetic LC patients whose serum type 4 collagen levels were abnormally high remained almost normal. Diabetic retinopathy was frequently found in those with positive U4C even in patients without albuminutia, indicating the presence of subclinical nephropathy. Conclusion: U4C is a useful marker of early diabetic nephropathy, probably even in the presence or absence of albuminuria.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a6d20834a7a12130f2d25dbf59efb08c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49166245,"asset_id":5726702,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49166245/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726702"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726702"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726702; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=5726702]").text(description); $(".js-view-count[data-work-id=5726702]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 5726702; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='5726702']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="5726701"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/5726701/Search_for_the_QCD_critical_point_in_nuclear_collisions_at_158A_GeV_at_the_CERN_Super_Proton_Synchrotron_SPS"><img alt="Research paper thumbnail of Search for the QCD critical point in nuclear collisions at 158A GeV at the CERN Super Proton Synchrotron (SPS" class="work-thumbnail" src="https://attachments.academia-assets.com/49166240/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/5726701/Search_for_the_QCD_critical_point_in_nuclear_collisions_at_158A_GeV_at_the_CERN_Super_Proton_Synchrotron_SPS">Search for the QCD critical point in nuclear collisions at 158A GeV at the CERN Super Proton Synchrotron (SPS</a></div><div class="wp-workCard_item"><span>Physical Review C</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Pion production in nuclear collisions at the SPS is investigated with the aim to search, in a res...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Pion production in nuclear collisions at the SPS is investigated with the aim to search, in a restricted domain of the phase diagram, for power-laws in the behavior of correlations which are compatible with critical QCD. We have analyzed interactions of nuclei of different size (p+p, C+C, Si+Si, Pb+Pb) at 158A GeV adopting, as appropriate observables, scaled factorial moments in a search for intermittent fluctuations in transverse dimensions. The analysis is performed for π + π − pairs with invariant mass very close to the two-pion threshold. In this sector one may capture critical fluctuations of the sigma component in a hadronic medium, even if the σ-meson has no well defined vacuum state. It turns out that for the Pb+Pb system the proposed analysis technique cannot be applied without entering the invariant mass region with strong Coulomb correlations.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="70a388cc3abb73a3accdb2dd2e33661c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49166240,"asset_id":5726701,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49166240/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726701"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726701"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726701; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=5726701]").text(description); $(".js-view-count[data-work-id=5726701]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 5726701; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='5726701']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "70a388cc3abb73a3accdb2dd2e33661c" } } $('.js-work-strip[data-work-id=5726701]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":5726701,"title":"Search for the QCD critical point in nuclear collisions at 158A GeV at the CERN Super Proton Synchrotron (SPS","internal_url":"https://www.academia.edu/5726701/Search_for_the_QCD_critical_point_in_nuclear_collisions_at_158A_GeV_at_the_CERN_Super_Proton_Synchrotron_SPS","owner_id":8317697,"coauthors_can_edit":true,"owner":{"id":8317697,"first_name":"László","middle_initials":null,"last_name":"Barna István","page_name":"LászlóBarnaIstván","domain_name":"independent","created_at":"2014-01-15T07:42:18.122-08:00","display_name":"László Barna István","url":"https://independent.academia.edu/L%C3%A1szl%C3%B3BarnaIstv%C3%A1n"},"attachments":[{"id":49166240,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49166240/thumbnails/1.jpg","file_name":"Search_for_the_QCD_critical_point_in_nuc20160927-25543-i758w.pdf","download_url":"https://www.academia.edu/attachments/49166240/download_file","bulk_download_file_name":"Search_for_the_QCD_critical_point_in_nuc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49166240/Search_for_the_QCD_critical_point_in_nuc20160927-25543-i758w-libre.pdf?1475018193=\u0026response-content-disposition=attachment%3B+filename%3DSearch_for_the_QCD_critical_point_in_nuc.pdf\u0026Expires=1740863023\u0026Signature=HmYRCZ4TYjixGdx44fHvA25UX1bdFL32-03Y1nkCQNXU~gzcAykpL~z5TJu-QvOoGyFQnXAup5xOGC-H0xO3wYzqi-pcISR4FpKCfOCDz~PSK-QpJMYm~nZhwCfUgwQx4A2RyE88Ggzk5S1PNO1dZW9Terf4uquyaumn2BYl0AtF5YgZEImHg6fFbtOMt13lv7w-DmOO8pyc4qcyNnzrVBhJfa4IYUEnQepSIopgVKC0CGNxOU1CK7y2Qz2p3sjmO3DbwgmyxptD3~hj1tHJrDuL5z6r5N9HoEYqyPG6c1F0lZ2al2UY7ZePL-zXYfmhfYG0tzTLbz28nrtEYKjbug__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="5726700"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/5726700/Study_on_endocronological_effects_of_radon_speleotherapy_on_respiratory_diseases"><img alt="Research paper thumbnail of Study on endocronological effects of radon speleotherapy on respiratory diseases" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/5726700/Study_on_endocronological_effects_of_radon_speleotherapy_on_respiratory_diseases">Study on endocronological effects of radon speleotherapy on respiratory diseases</a></div><div class="wp-workCard_item"><span>International Journal of Radiation Biology</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Radon, as a radioactive noble gas of natural origin, is generally present in the atmosphere of ca...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Radon, as a radioactive noble gas of natural origin, is generally present in the atmosphere of caves during the speleotherapeutic treatment of different diseases. However, the role of radon in the therapeutic effect is not fully clarified yet. Endocrine parameter levels may be influenced by radon-like endocrine levels in balneotherapeutic treatments (bath treatment). For this reason changes of these parameters were examined in this study. A total of 81 speleotherapy patients were involved in the survey. They spent four hours daily in Tapolca Cave, five days a week, for two weeks. In this study, the thyreoiedea stimulating hormone, free triiodine-tironin, free thyroxine, prolactine, cortisol, dehydroepiandrosterone sulphate, adrenocorticotropic hormone, and beta endorphine levels of the body were examined before and after the treatment. After statistical analysis of the data a significant decrease of cortisol levels of patients was found, which was not directly correlated with radon concentration. In the case of thyroid hormones, there were no significantly detectable changes of the hormone levels except for low radon concentration levels a significant decrease in the free thyroxine and the thyreoiedea stimulating hormone level of male patients was observed. Speleotherapy has an effect on the level of endocrine hormones; however, no direct correlation with differences in radon level was found. For patients whose endocrine levels fell outside the normal endocrine parameter values, more striking changes in endocrine hormone levels were seen, but changes of these parameters could not be statistically analyzed due to the small number of cases.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726700"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726700"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726700; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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Baatar, B.; Barna, D.; Bartke, J.; Beck, H.; Betev, L.; Bialkowska, H.; Blume, C.; B...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Anticic, T.; Baatar, B.; Barna, D.; Bartke, J.; Beck, H.; Betev, L.; Bialkowska, H.; Blume, C.; Boimska, B.; Book, J.; Botje, M.; Bracinik, J.; Buncic, P.; Cerny, V.; Christakoglou, P.; Chung, P.; Chvala, O.; Cramer, JG; Csató, P.; Dinkelaker, P.; Eckardt, V.; Fischer, HG; Fodor, Z.; ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726699"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726699"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726699; 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Prominent non-Gaussian tails are observed in the pion pair transverse momentum (outward) and in the beam (longitudinal) directions. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="1069456" id="papers"><div class="js-work-strip profile--work_container" data-work-id="5726707"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/5726707/Energy_Dependence_of_Multiplicity_Fluctuations_in_Heavy_Ion_Collisions"><img alt="Research paper thumbnail of Energy Dependence of Multiplicity Fluctuations in Heavy Ion Collisions" class="work-thumbnail" src="https://attachments.academia-assets.com/32764708/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/5726707/Energy_Dependence_of_Multiplicity_Fluctuations_in_Heavy_Ion_Collisions">Energy Dependence of Multiplicity Fluctuations in Heavy Ion Collisions</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The energy dependence of multiplicity fluctuations was studied for the most central Pb + Pb colli...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The energy dependence of multiplicity fluctuations was studied for the most central Pb + Pb collisions at 20A, 30A, 40A, 80A and 158A GeV by the NA49 experiment at the CERN SPS. The multiplicity distribution for negatively and positively charged hadrons is significantly narrower than Poisson one for all energies. No significant structure in energy dependence of the scaled variance of multiplicity fluctuations is observed. The measured scaled variance is lower than the one predicted by the grand-canonical formulation of the hadron-resonance gas model. The results for scaled variance are in approximate agreement with the string-hadronic model UrQMD.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ff2f83032e86437ecf56f4eda7860b57" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":32764708,"asset_id":5726707,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/32764708/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726707"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726707"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726707; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=5726707]").text(description); $(".js-view-count[data-work-id=5726707]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 5726707; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='5726707']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="5726706"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/5726706/Matrix_Metalloproteinase_Inhibitors_A_Critical_Appraisal_of_Design_Principles_and_Proposed_Therapeutic_Utility"><img alt="Research paper thumbnail of Matrix Metalloproteinase Inhibitors: A Critical Appraisal of Design Principles and Proposed Therapeutic Utility" class="work-thumbnail" src="https://attachments.academia-assets.com/49166329/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/5726706/Matrix_Metalloproteinase_Inhibitors_A_Critical_Appraisal_of_Design_Principles_and_Proposed_Therapeutic_Utility">Matrix Metalloproteinase Inhibitors: A Critical Appraisal of Design Principles and Proposed Therapeutic Utility</a></div><div class="wp-workCard_item"><span>Drugs</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Matrix metalloproteinases (MMPs) play an important role in tissue remodelling associated with var...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Matrix metalloproteinases (MMPs) play an important role in tissue remodelling associated with various physiological and pathological processes, such as morphogenesis, angiogenesis, tissue repair, arthritis, chronic heart failure, chronic obstructive pulmonary disease, chronic inflammation and cancer metastasis. As a result, MMPs are considered to be viable drug targets in the therapy of these diseases. Despite the high therapeutic potential of MMP inhibitors (MMPIs), all clinical trials have failed to date, except for doxycycline for periodontal disease. This can be attributed to (i) poor selectivity of the MMPIs, (ii) poor target validation for the targeted therapy and (iii) poorly defined predictive preclinical animal models for safety and efficacy. Lessons from previous failures, such as recent discoveries of oxidative/ nitrosative activation and phosphorylation of MMPs, as well as novel nonmatrix related intra-and extracellular targets of MMP, give new hope for MMPI development for both chronic and acute diseases. In this article we critically review the major structural determinants of the selectivity and the milestones of past design efforts of MMPIs where 2-/3-dimensional structurebased methods were intensively applied. We also analyse the in vitro screening and preclinical/clinical pharmacology approaches, with particular emphasis on drawing conclusions on how to overcome efficacy and safety problems through better target validation and design of preclinical studies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bbf286d1e9b183e7ae6db863912d0ada" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49166329,"asset_id":5726706,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49166329/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726706"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726706"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726706; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=5726706]").text(description); $(".js-view-count[data-work-id=5726706]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 5726706; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='5726706']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="5726705"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/5726705/HbA_1c_levels_and_erythrocyte_transport_functions_in_complication_free_type_1_diabetic_children_and_adolescents"><img alt="Research paper thumbnail of HbA 1c levels and erythrocyte transport functions in complication-free type 1 diabetic children and adolescents" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/5726705/HbA_1c_levels_and_erythrocyte_transport_functions_in_complication_free_type_1_diabetic_children_and_adolescents">HbA 1c levels and erythrocyte transport functions in complication-free type 1 diabetic children and adolescents</a></div><div class="wp-workCard_item"><span>Acta Diabetologica</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Higher erythrocyte sodium-lithium countertransport activity (SLC) is implicated in the developmen...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Higher erythrocyte sodium-lithium countertransport activity (SLC) is implicated in the development of diabetic nephropathy. Altered glucose homeostasis and genetic susceptibility are claimed to play a role in the elevation of SLC. We aimed to test whether metabolic control or the genetic variants of G protein beta 3 (Gb3) subunits determine SLC and other erythrocyte transport activities in complication-free stage of type 1 diabetes. A total of 96 complication-free type 1 diabetic children and adolescents were enrolled. SLC, Na+/K+-ATPase (NAK) and Ca2+-ATPase (CA) were measured by functional assays in erythrocytes. Gb3-C825T polymorphism was determined by PCR-RFLP. Results were related to HbA1c and were compared to those of 97 healthy controls. SLC activity was higher in diabetics (387±146 vs. 280±65 mmol/RBC · hour) and correlated with HbA1c levels (y=0.004x+6.42, r=0.33, n=96, p<0.01). NAK and CA activities were unaltered. The prevalence of 825T allele was similar in the patient and control groups (0.34 vs 0.37) and no differences in enzyme activities were observed between the 825T allele-positive and negative subjects. Although metabolic control correlated with SLC, other membrane functions were not affected. Therefore we hypothesize that the relationship between advanced glycation and SLC elevation is not causative. Rather, a genetic susceptibility for the coexistence of poor metabolic control and higher SLC is more likely. However, the presence of Gb3-C825T variant is not likely to be a risk factor for SLC-elevation and altered metabolic control diabetes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726705"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726705"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726705; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=5726705]").text(description); 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</script> <div class="js-work-strip profile--work_container" data-work-id="5726704"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/5726704/Energy_dependence_of_varphi_meson_production_in_central_Pb_Pb_collisions_at_sNN_6_to_17_GeV"><img alt="Research paper thumbnail of Energy dependence of varphi meson production in central Pb+Pb collisions at sNN=6 to 17 GeV" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/5726704/Energy_dependence_of_varphi_meson_production_in_central_Pb_Pb_collisions_at_sNN_6_to_17_GeV">Energy dependence of varphi meson production in central Pb+Pb collisions at sNN=6 to 17 GeV</a></div><div class="wp-workCard_item"><span>Physical Review C</span><span>, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726704"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726704"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726704; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=5726704]").text(description); $(".js-view-count[data-work-id=5726704]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 5726704; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='5726704']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="5726703"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/5726703/Centrality_and_system_size_dependence_of_multiplicity_fluctuations_in_nuclear_collisions_at_158A_GeV"><img alt="Research paper thumbnail of Centrality and system size dependence of multiplicity fluctuations in nuclear collisions at 158A GeV" class="work-thumbnail" src="https://attachments.academia-assets.com/49166223/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/5726703/Centrality_and_system_size_dependence_of_multiplicity_fluctuations_in_nuclear_collisions_at_158A_GeV">Centrality and system size dependence of multiplicity fluctuations in nuclear collisions at 158A GeV</a></div><div class="wp-workCard_item"><span>Physical Review C</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The centrality and system size dependence of multiplicity fluctuations of charged particles produ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The centrality and system size dependence of multiplicity fluctuations of charged particles produced in nuclear collisions at $158 A$ GeV was studied by the NA49 collaboration. Centrality selected Pb+Pb collisions, semi-central C+C and Si+Si collisions as well as inelastic p+p interactions were analyzed. The number of projectile participants determined on an event-by-event basis was used to characterize the collision centrality. The scaled variance of the multiplicity distribution obtained in the forward rapidity region ($1.1 <y_{c.m.} <2.6$) shows a significant increase towards peripheral collisions. The results are similar for negatively and positively charged particles and about 50% larger for all charged particles. String-hadronic models of nuclear reactions without the fusion process do not reproduce the rise of fluctuations from central towards peripheral collisions. The measured centrality dependence can be reproduced in superposition models with the assumption of contributions from target participants to particle production in the forward hemisphere or in string models with fusion.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="766fd2578d8510b84c18b0a8a823e58f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49166223,"asset_id":5726703,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49166223/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726703"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726703"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726703; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="5726702"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/5726702/Prevalence_of_symptomes_of_the_metabolic_syndrome_in_kidney_transplant_recipients"><img alt="Research paper thumbnail of Prevalence of symptomes of the metabolic syndrome in kidney transplant recipients" class="work-thumbnail" src="https://attachments.academia-assets.com/49166245/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/5726702/Prevalence_of_symptomes_of_the_metabolic_syndrome_in_kidney_transplant_recipients">Prevalence of symptomes of the metabolic syndrome in kidney transplant recipients</a></div><div class="wp-workCard_item"><span>Diabetes Research and Clinical Practice</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">patients with normoalbumimnia(NOR; ~19mg/gCr)(ptO.OOl).Moreover, 22% of patients with NOR had hig...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">patients with normoalbumimnia(NOR; ~19mg/gCr)(ptO.OOl).Moreover, 22% of patients with NOR had higher type 4 collagen levels than a normal value. U4C levels were positively correlated with UA levels in all the patients with and without nephropathy (t=O.695). On the other hand, U4C values of non-diabetic LC patients whose serum type 4 collagen levels were abnormally high remained almost normal. Diabetic retinopathy was frequently found in those with positive U4C even in patients without albuminutia, indicating the presence of subclinical nephropathy. Conclusion: U4C is a useful marker of early diabetic nephropathy, probably even in the presence or absence of albuminuria.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a6d20834a7a12130f2d25dbf59efb08c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49166245,"asset_id":5726702,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49166245/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726702"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726702"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726702; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="5726701"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/5726701/Search_for_the_QCD_critical_point_in_nuclear_collisions_at_158A_GeV_at_the_CERN_Super_Proton_Synchrotron_SPS"><img alt="Research paper thumbnail of Search for the QCD critical point in nuclear collisions at 158A GeV at the CERN Super Proton Synchrotron (SPS" class="work-thumbnail" src="https://attachments.academia-assets.com/49166240/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/5726701/Search_for_the_QCD_critical_point_in_nuclear_collisions_at_158A_GeV_at_the_CERN_Super_Proton_Synchrotron_SPS">Search for the QCD critical point in nuclear collisions at 158A GeV at the CERN Super Proton Synchrotron (SPS</a></div><div class="wp-workCard_item"><span>Physical Review C</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Pion production in nuclear collisions at the SPS is investigated with the aim to search, in a res...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Pion production in nuclear collisions at the SPS is investigated with the aim to search, in a restricted domain of the phase diagram, for power-laws in the behavior of correlations which are compatible with critical QCD. We have analyzed interactions of nuclei of different size (p+p, C+C, Si+Si, Pb+Pb) at 158A GeV adopting, as appropriate observables, scaled factorial moments in a search for intermittent fluctuations in transverse dimensions. The analysis is performed for π + π − pairs with invariant mass very close to the two-pion threshold. In this sector one may capture critical fluctuations of the sigma component in a hadronic medium, even if the σ-meson has no well defined vacuum state. It turns out that for the Pb+Pb system the proposed analysis technique cannot be applied without entering the invariant mass region with strong Coulomb correlations.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="70a388cc3abb73a3accdb2dd2e33661c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49166240,"asset_id":5726701,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49166240/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726701"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726701"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726701; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="5726700"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/5726700/Study_on_endocronological_effects_of_radon_speleotherapy_on_respiratory_diseases"><img alt="Research paper thumbnail of Study on endocronological effects of radon speleotherapy on respiratory diseases" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/5726700/Study_on_endocronological_effects_of_radon_speleotherapy_on_respiratory_diseases">Study on endocronological effects of radon speleotherapy on respiratory diseases</a></div><div class="wp-workCard_item"><span>International Journal of Radiation Biology</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Radon, as a radioactive noble gas of natural origin, is generally present in the atmosphere of ca...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Radon, as a radioactive noble gas of natural origin, is generally present in the atmosphere of caves during the speleotherapeutic treatment of different diseases. However, the role of radon in the therapeutic effect is not fully clarified yet. Endocrine parameter levels may be influenced by radon-like endocrine levels in balneotherapeutic treatments (bath treatment). For this reason changes of these parameters were examined in this study. A total of 81 speleotherapy patients were involved in the survey. They spent four hours daily in Tapolca Cave, five days a week, for two weeks. In this study, the thyreoiedea stimulating hormone, free triiodine-tironin, free thyroxine, prolactine, cortisol, dehydroepiandrosterone sulphate, adrenocorticotropic hormone, and beta endorphine levels of the body were examined before and after the treatment. After statistical analysis of the data a significant decrease of cortisol levels of patients was found, which was not directly correlated with radon concentration. In the case of thyroid hormones, there were no significantly detectable changes of the hormone levels except for low radon concentration levels a significant decrease in the free thyroxine and the thyreoiedea stimulating hormone level of male patients was observed. Speleotherapy has an effect on the level of endocrine hormones; however, no direct correlation with differences in radon level was found. For patients whose endocrine levels fell outside the normal endocrine parameter values, more striking changes in endocrine hormone levels were seen, but changes of these parameters could not be statistically analyzed due to the small number of cases.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726700"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726700"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726700; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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Baatar, B.; Barna, D.; Bartke, J.; Beck, H.; Betev, L.; Bialkowska, H.; Blume, C.; B...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Anticic, T.; Baatar, B.; Barna, D.; Bartke, J.; Beck, H.; Betev, L.; Bialkowska, H.; Blume, C.; Boimska, B.; Book, J.; Botje, M.; Bracinik, J.; Buncic, P.; Cerny, V.; Christakoglou, P.; Chung, P.; Chvala, O.; Cramer, JG; Csató, P.; Dinkelaker, P.; Eckardt, V.; Fischer, HG; Fodor, Z.; ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726699"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726699"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726699; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=5726699]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":5726699,"title":"The NA49 Collaboration","internal_url":"https://www.academia.edu/5726699/The_NA49_Collaboration","owner_id":8317697,"coauthors_can_edit":true,"owner":{"id":8317697,"first_name":"László","middle_initials":null,"last_name":"Barna István","page_name":"LászlóBarnaIstván","domain_name":"independent","created_at":"2014-01-15T07:42:18.122-08:00","display_name":"László Barna István","url":"https://independent.academia.edu/L%C3%A1szl%C3%B3BarnaIstv%C3%A1n"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="5726698"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/5726698/Three_dimensional_two_pion_source_image_from_Pb_Pb_collisions_at_s_NN_17_3_GeV_New_constraints_for_source_breakup_dynamics"><img alt="Research paper thumbnail of Three-dimensional two-pion source image from Pb + Pb collisions at s NN = 17.3 GeV : New constraints for source breakup dynamics" class="work-thumbnail" src="https://attachments.academia-assets.com/49166222/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/5726698/Three_dimensional_two_pion_source_image_from_Pb_Pb_collisions_at_s_NN_17_3_GeV_New_constraints_for_source_breakup_dynamics">Three-dimensional two-pion source image from Pb + Pb collisions at s NN = 17.3 GeV : New constraints for source breakup dynamics</a></div><div class="wp-workCard_item"><span>Physics Letters B</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Source imaging methodology is used to provide a three-dimensional two-pion source function for mi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Source imaging methodology is used to provide a three-dimensional two-pion source function for mid-rapidity pion pairs with pT < 70 MeV/c in central (0 − 7%) Pb+Pb collisions at √ s NN =17.3 GeV. Prominent non-Gaussian tails are observed in the pion pair transverse momentum (outward) and in the beam (longitudinal) directions. Model calculations reproduce them with the assumption of Bjorken longitudinal boost invariance and transverse flow blast-wave dynamics; they also yield a proper time for breakup and emission duration for the pion source.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8545a424a424209f6ff29b4c60bbaf1c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49166222,"asset_id":5726698,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49166222/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5726698"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5726698"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5726698; 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