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method="get" id="searchform" action="https://www.reactionbiology.com/" role="form"> <div class="input-group"> <input type="text" value="" name="s" id="s" class="form-control" placeholder="Search" /> <span class="input-group-btn"> <button class="btn btn-danger" type="submit">Search</button> </span> </div> </form> </div> </div> </div> <div id="et-main-area"> <section id="block-views-blockheader-slider" class="block-views-page"> <div class="block-views-blockheader"> <div class="view-content"> <div class="fixed-element field field--name-field-paragraph"> <div class="view-row"> <div class="paragraph-view-type-banner flex"> <div class="bgr-image-header"> <img src="https://www.reactionbiology.com/wp-content/uploads/2023/07/header-testimonials.jpg" alt="Blog"> </div> <div class="container center"> <div class="field field--name-field-headline-big field--type-string field--label-hidden field__items"> <div class="field__item">Reading Room</div> </div> </div> </div> </div> </div> </div> </div> </section> <div id="main-content"> <div id="block-proquinase-breadcrumbs" class="color-scheme-turquoise block block-system block-system-breadcrumb-block"> <div class="container"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <ol> <li><a href="https://www.reactionbiology.com">Home</a></li> <li>Resources</li><li>Reading room</li> <li>Blog</li> </ol> </nav> </div> </div> <div class="view-container view-simple-page-conent"> <div class="container"> <article id="post-216" class="post-216 page type-page status-publish hentry" itemtype="https://schema.org/CreativeWork" itemscope=""> <div class="entry-content entry-content-servises"> <h1>Drug Discovery Blog</h1> <div class="text-mit-bild-text"> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__items"> <p>Every drug discovery program has its own challenges. Scientists at Reaction Biology have 20 years of experience in problem-solving and decision making. Via blogs, we like to share some of our experiences and insight into our assays with the drug discovery community to support your journey to a preclinical drug candidate.</p> </div> </div> </div> </article> </div> </div> <!-- Blog --> <div class="paragraph paragraph--type--view paragraph--view-mode--default"> <div class="view container view-blog view-id-blog view-display-id-block_1"> <div class="view-content"> <div class="views-row"> <div class="views-field views-field-nothing"> <span class="field-content"><h3><a href="https://www.reactionbiology.com/resources/reading-room/blog/hollow-fibers-a-bridge-to-preclinical-success">Hollow Fibers: A Bridge to Preclinical Success</a></h3> <time class="datetime" datetime="2024-10-01T11:18:32+00:00">1 Oct 2024</time> <p>Which tumor cell line is best suited for your research? Which lead agents from your library could show promising results in <i>in vivo</i> models? Enter the <i>in vivo</i> hollow fiber model—a groundbreaking tool in preclinical research. How are they developed, and what are their key advantages? Read the blog to find out more!</p> <div class="blog-detail"> <a href="https://www.reactionbiology.com/resources/reading-room/blog/hollow-fibers-a-bridge-to-preclinical-success" hreflang="en">Read more</a> </div> </span> </div> <div class="views-field views-field-field-image"> <div class="field-content"> <a href="https://www.reactionbiology.com/resources/reading-room/blog/hollow-fibers-a-bridge-to-preclinical-success" hreflang="en"> <img src="https://www.reactionbiology.com/wp-content/uploads/2023/07/mouse-tubes.jpg" alt="Hollow Fibers: A Bridge to Preclinical Success" title="Hollow Fibers: A Bridge to Preclinical Success" typeof="foaf:Image" class="image-style-image-16-9" width="400" height="225"> </a> </div> </div> </div> <div class="views-row"> <div class="views-field views-field-nothing"> <span class="field-content"><h3><a href="https://www.reactionbiology.com/resources/reading-room/blog/spotlight-activity-based-kinase-assay-formats/">Spotlight: Activity-Based Kinase Assay Formats</a></h3> <time class="datetime" datetime="2024-08-29T14:14:51+00:00">29 Aug 2024</time> <p>In the rapidly evolving field of kinase drug discovery, the accurate and efficient evaluation of kinase activity is crucial for identifying potent and selective inhibitors. At Reaction Biology, we offer two assay formats for activity-based kinase screening. In this blog, we compare the assay formats to help you choose the assay that best fits your research needs. </p> <div class="blog-detail"> <a href="https://www.reactionbiology.com/resources/reading-room/blog/spotlight-activity-based-kinase-assay-formats/" hreflang="en">Read more</a> </div> </span> </div> <div class="views-field views-field-field-image"> <div class="field-content"> <a href="https://www.reactionbiology.com/resources/reading-room/blog/spotlight-activity-based-kinase-assay-formats/" hreflang="en"> <img src="https://www.reactionbiology.com/wp-content/uploads/2024/08/adp-glo.png" alt="Spotlight: Activity-Based Kinase Assay Formats" title="Spotlight: Activity-Based Kinase Assay Formats" typeof="foaf:Image" class="image-style-image-16-9" width="400" height="225"> </a> </div> </div> </div> <div class="views-row"> <div class="views-field views-field-nothing"> <span class="field-content"><h3><a href="https://www.reactionbiology.com/resources/reading-room/blog/subqperior-why-superior">SubQperior™: Why Superior?</a></h3> <time class="datetime" datetime="2024-08-26T07:15:51+00:00">26 Aug 2024</time> <p>Do you struggle with variable tumor growth in your <i>in vivo</i> models, compromising your research? SubQperior™ offers a superior solution, enhancing tumor growth and consistency for more reliable and impactful results. Ready to elevate your study outcomes? Read the blog to learn more.</p> <div class="blog-detail"> <a href="https://www.reactionbiology.com/resources/reading-room/blog/subqperior-why-superior" hreflang="en">Read more</a> </div> </span> </div> <div class="views-field views-field-field-image"> <div class="field-content"> <a href="https://www.reactionbiology.com/resources/reading-room/blog/subqperior-why-superior" hreflang="en"> <img src="https://www.reactionbiology.com/wp-content/uploads/2024/08/subqperior.jpg" alt="SubQperior™: Why Superior?" title="SubQperior™: Why Superior?" typeof="foaf:Image" class="image-style-image-16-9" width="400" height="225"> </a> </div> </div> </div> <div class="views-row"> <div class="views-field views-field-nothing"> <span class="field-content"><h3><a href="https://www.reactionbiology.com/resources/reading-room/blog/testing-kinase-inhibitors">Testing kinase inhibitors where it matters: Drug screening in intact cells</a></h3> <time class="datetime" datetime="2024-08-13T19:26:54+00:00">13 Aug 2024</time> <p>While biochemical assays will likely remain a critical entry point for novel molecules into the kinase inhibitor drug discovery pipeline, the field has collectively achieved a state of maturation that increasingly demands priority for cell-based assays right out of the gate.</p> <div class="blog-detail"> <a href="https://www.reactionbiology.com/resources/reading-room/blog/testing-kinase-inhibitors" hreflang="en">Read more</a> </div> </span> </div> <div class="views-field views-field-field-image"> <div class="field-content"> <a href="https://www.reactionbiology.com/resources/reading-room/blog/testing-kinase-inhibitors" hreflang="en"> <img src="https://www.reactionbiology.com/wp-content/uploads/2023/07/PKL1-Inhibition.png" alt="Testing kinase inhibitors where it matters: Drug screening in intact cells" title="Testing kinase inhibitors where it matters: Drug screening in intact cells" typeof="foaf:Image" class="image-style-image-16-9" width="400" height="225"> </a> </div> </div> </div> <div class="views-row"> <div class="views-field views-field-nothing"> <span class="field-content"><h3><a href="https://www.reactionbiology.com/resources/reading-room/blog/macrophage-targeted-immunotherapy/">Macrophage-Targeted Immunotherapy: Unveiling New Frontiers in Cancer Treatment</a></h3> <time class="datetime" datetime="2024-07-18T13:57:57+00:00">18 Jul 2024</time> <p>The fight against cancer continues to evolve, with immunotherapies emerging as a powerful weapon. While initial focus centered on the adaptive immune system, a new wave of therapies targets macrophages, versatile immune cells with a crucial role in the tumor microenvironment (TME). </p> <div class="blog-detail"> <a href="https://www.reactionbiology.com/resources/reading-room/blog/macrophage-targeted-immunotherapy/" hreflang="en">Read more</a> </div> </span> </div> <div class="views-field views-field-field-image"> <div class="field-content"> <a href="https://www.reactionbiology.com/resources/reading-room/blog/macrophage-targeted-immunotherapy/" hreflang="en"> <img src="https://www.reactionbiology.com/wp-content/uploads/2023/07/strategies-of-immunotherapies.png" alt="Macrophage-Targeted Immunotherapy: Unveiling New Frontiers in Cancer Treatment" title="Macrophage-Targeted Immunotherapy: Unveiling New Frontiers in Cancer Treatment" typeof="foaf:Image" class="image-style-image-16-9" width="400" height="225"> </a> </div> </div> </div> <div class="views-row"> <div class="views-field views-field-nothing"> <span class="field-content"><h3><a href="https://www.reactionbiology.com/step-by-step-guide-to-kinase-inhibitor-development">Step-by-Step Guide to Kinase Inhibitor Development</a></h3> <time class="datetime" datetime="2024-07-02T02:04:17+00:00">2 Jul 2024</time> <p>Kinase inhibitors hold promise for treating diseases like cancer. This blog unveils the multi step process of bringing a drug candidate to market, specifically focusing on lead identification and optimization using an array of biochemical, biophysical, cellular, and <i>in vivo</i> assays. Explore how science transforms promising compounds into potential new treatments.</p> <div class="blog-detail"> <a href="https://www.reactionbiology.com/step-by-step-guide-to-kinase-inhibitor-development" hreflang="en">Read more</a> </div> </span> </div> <div class="views-field views-field-field-image"> <div class="field-content"> <a href="https://www.reactionbiology.com/step-by-step-guide-to-kinase-inhibitor-development" hreflang="en"> <img src="https://www.reactionbiology.com/wp-content/uploads/2024/07/kinase-drug-development.jpg" alt="Step-by-Step Guide to Kinase Inhibitor Development" title="Step-by-Step Guide to Kinase Inhibitor Development" typeof="foaf:Image" class="image-style-image-16-9" width="400" height="225"> </a> </div> </div> </div> <div class="views-row"> <div class="views-field views-field-nothing"> <span class="field-content"><h3><a href="https://www.reactionbiology.com/the-evolution-and-importance-of-syngeneic-tumor-models-in-immunotherapy-research/">The Evolution and Importance of Syngeneic Tumor Models in Immunotherapy Research</a></h3> <time class="datetime" datetime="2024-06-11T13:45:03+00:00">11 Jun 2024</time> <p>Immuno-oncology (IO) therapies are revolutionizing cancer treatment, but their complex interactions with the tumor microenvironment pose a challenge in preclinical testing. Enter syngeneic models: how do they differ from traditional models, and how can they be harnessed for IO drug development? Dive into the blog for answers.</p> <div class="blog-detail"> <a href="https://www.reactionbiology.com/the-evolution-and-importance-of-syngeneic-tumor-models-in-immunotherapy-research/" hreflang="en">Read more</a> </div> </span> </div> <div class="views-field views-field-field-image"> <div class="field-content"> <a href="https://www.reactionbiology.com/the-evolution-and-importance-of-syngeneic-tumor-models-in-immunotherapy-research/" hreflang="en"> <img src="https://www.reactionbiology.com/wp-content/uploads/2023/07/syngeneic-cell-diagram.png" alt="The Evolution and Importance of Syngeneic Tumor Models in Immunotherapy Research" title="The Evolution and Importance of Syngeneic Tumor Models in Immunotherapy Research" typeof="foaf:Image" class="image-style-image-16-9" width="400" height="225"> </a> </div> </div> </div> <div class="views-row"> <div class="views-field views-field-nothing"> <span class="field-content"><h3><a href="https://www.reactionbiology.com/promise-and-perils-of-adc-drug-development">The Promise and Peril of Antibody-Drug Conjugates (ADCs) in Cancer Treatment</a></h3> <time class="datetime" datetime="2024-06-04T08:00:45+00:00">4 Jun 2024</time> <p>Antibody-drug conjugates (ADCs) are emerging as powerful tools in the treatment against cancer. While they hold immense promise for targeted therapy, challenges in efficacy and safety remain. This blog explores the potential and limitations of ADCs, examining their design, function, and ongoing research for a comprehensive understanding of this innovative approach to cancer treatment.</p> <div class="blog-detail"> <a href="https://www.reactionbiology.com/promise-and-perils-of-adc-drug-development" hreflang="en">Read more</a> </div> </span> </div> <div class="views-field views-field-field-image"> <div class="field-content"> <a href="https://www.reactionbiology.com/promise-and-perils-of-adc-drug-development" hreflang="en"> <img src="https://www.reactionbiology.com/wp-content/uploads/2023/07/mechanism-of-action-of-an-adc.png" alt="The Promise and Peril of Antibody-Drug Conjugates (ADCs) in Cancer Treatment" title="The Promise and Peril of Antibody-Drug Conjugates (ADCs) in Cancer Treatment" typeof="foaf:Image" class="image-style-image-16-9" width="400" height="225"> </a> </div> </div> </div> <div class="views-row"> <div class="views-field views-field-nothing"> <span class="field-content"><h3><a href="https://www.reactionbiology.com/choosing-the-right-assay-for-your-kinase-drug-discovery/">Choosing the Right Assay for Your Kinase Drug Discovery</a></h3> <time class="datetime" datetime="2024-05-30T08:00:11+00:00">30 May 2024</time> <p>Kinases, the master regulators of cellular signaling pathways, are prime targets for drug discovery. But with so many assays available to measure their activity, how do you choose the right tool for your research? This blog delves into the diverse landscape of kinase assays, empowering you to select the most effective method for investigating your drug targets.</p> <div class="blog-detail"> <a href="https://www.reactionbiology.com/choosing-the-right-assay-for-your-kinase-drug-discovery/" hreflang="en">Read more</a> </div> </span> </div> <div class="views-field views-field-field-image"> <div class="field-content"> <a href="https://www.reactionbiology.com/choosing-the-right-assay-for-your-kinase-drug-discovery/" hreflang="en"> <img src="https://www.reactionbiology.com/wp-content/uploads/2023/07/radiometric-assay-table-v4.jpg" alt="Choosing the Right Assay for Your Kinase Drug Discovery" title="Choosing the Right Assay for Your Kinase Drug Discovery" typeof="foaf:Image" class="image-style-image-16-9" width="400" height="225"> </a> </div> </div> </div> <div class="views-row"> <div class="views-field views-field-nothing"> <span class="field-content"><h3><a href="https://www.reactionbiology.com/seeing-is-believing-how-imaging-orthotopic-models-might-pave-way-for-bladder-cancer-breakthroughs/">Seeing is believing: How imaging orthotopic models might pave the way for bladder cancer breakthroughs</a></h3> <time class="datetime" datetime="2024-05-15T14:58:16+00:00">15 May 2024</time> <p>Modelling bladder cancer (BC) for preclinical drug development is notoriously challenging. Due to the route of administration of BC treatments, orthotopic modelling represent the go-to-option for physiological relevance. Here we review current resources for <i>in vivo</i> BC research and describe the characterization of the MB49_luc bioluminescent model.</p> <div class="blog-detail"> <a href="https://www.reactionbiology.com/seeing-is-believing-how-imaging-orthotopic-models-might-pave-way-for-bladder-cancer-breakthroughs/" hreflang="en">Read more</a> </div> </span> </div> <div class="views-field views-field-field-image"> <div class="field-content"> <a href="https://www.reactionbiology.com/seeing-is-believing-how-imaging-orthotopic-models-might-pave-way-for-bladder-cancer-breakthroughs/" hreflang="en"> <img src="https://www.reactionbiology.com/wp-content/uploads/2024/05/rat.png" alt="Seeing is believing: How imaging orthotopic models might pave the way for bladder cancer breakthroughs" title="Seeing is believing: How imaging orthotopic models might pave the way for bladder cancer breakthroughs" typeof="foaf:Image" class="image-style-image-16-9" width="400" height="225"> </a> </div> </div> </div> <div class="pagination-content"><div class="pagination"><span aria-current="page" class="page-numbers current">1</span> <a class="page-numbers" href="https://www.reactionbiology.com/resources/reading-room/blog/page/2/">2</a> <a class="next page-numbers" href="https://www.reactionbiology.com/resources/reading-room/blog/page/2/">Next &raquo;</a></div></div> </div> </div> </div> </div> <footer id="main-footer" aria-label="Site" itemtype="https://schema.org/WPFooter" itemscope=""> <div class="region region-footer"> <div class="color-scheme-turquoise block block-block-content" id="block-letsworktogether"> <div class="bgr-image-footer"> <img src="https://www.reactionbiology.com/wp-content/themes/Divi-child/images/lets-discover-footer.jpg " alt=""> </div> <div class="footer-wrapper"><div class="field field--name-field-link field--type-link field--label-hidden field__items"><div class="field field--name-field-text field--type-string field--label-hidden field__items">Let&#8217;s discover together.</div> <div class="textwidget"><p><a href="/contact/contact-us">Contact us</a></p> </div> </div></div> </div> <div id="et-footer-nav"> <div class="container"> <ul id="menu-footer-menu" class="bottom-nav"><li id="menu-item-37" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-37"><a href="https://www.reactionbiology.com/terms-and-conditions/">Terms and Conditions</a></li> <li id="menu-item-38" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-38"><a href="https://www.reactionbiology.com/privacy-policy/">Privacy Policy</a></li> <li id="menu-item-39" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-39"><a href="https://www.reactionbiology.com/sitemap/">Site Map</a></li> <li id="menu-item-7757" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-7757"><a href="https://www.reactionbiology.com/contact/contact-us/">Contact Us</a></li> <li id="menu-item-41" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-41"><a href="https://www.reactionbiology.com/company/about-us/">Company</a></li> <li id="menu-item-42" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-42"><a href="https://www.reactionbiology.com/faq/">FAQ</a></li> </ul> </div> </div> <!-- #et-footer-nav --> </div> <div id="footer-bottom"> <div class="container clearfix"> <ul class="et-social-icons"> <li class="et-social-icon et-social-facebook"> <a href="https://www.facebook.com/ReactionBiology" class="icon"> <span>Facebook</span> </a> </li> <li class="et-social-icon et-social-linkedin"> <a href="https://www.linkedin.com/company/reaction-biology-corporation" class="icon"> <span>Google</span> </a> </li> <li class="et-social-icon et-social-twitter"> <a href="https://twitter.com/ReactionBiology" class="icon"> <span>Twitter</span> </a> </li> </ul><div id="footer-info">© <span class="year">2024</span> <strong>Reaction Biology</strong>. 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