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Saturday, November 23, 2024</div><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_SCIENCE" target="_blank" href="https://www.bioworld.com/womens_health">Breaking News: Healing a health divide (that’s long overdue)</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD" href="/articles/517055-try-bioworld-for-free-for-two-weeks">Breaking News: Try BioWorld for free for two weeks</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_MEDTECH" href="/articles/517055-try-bioworld-for-free-for-two-weeks">Breaking News: Try BioWorld for free for two weeks</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_ASIA" href="/articles/714414-duchembio-files-for-ipo-to-grow-radiopharma-business">Breaking News: Duchembio files for IPO to grow radiopharma business</a></section><div id="section-2" class="main-body"> <script src="/javascripts/pages/article.js"></script> <div id="breadcrumbs" class="breadcrumbs"><a class="" href="/">Home</a> » <a class="" href="/topics">Topics</a> » BioWorld Science, Respiratory</div> <div class="box1 article-topic"> <div class="records"> <h1 class="page-title"> BioWorld Science, Respiratory <div class="rss"> <a href="/rss/topic/520-bioworld-science"> <img alt="BioWorld Science, Respiratory RSS Feed" height="16" width="16" loading="lazy" src="/images/icons/rss.gif" /> RSS </a> </div> </h1> <article class="record article-summary "> <div class="image"><a title="More than 100M cells included in the human cell atlas" class="url" rel="" target="" href="https://www.bioworld.com/articles/714679-more-than-100m-cells-included-in-the-human-cell-atlas"><img width="650" height="488" alt="D-rendered image showing atlas of human embryonic skeletal development" title="D-rendered image showing atlas of human embryonic skeletal development" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-source/Embryonic-skeletal-development-hero-11-21.jpg?height=488&t=1732207101&width=650" /></a></div> <div class="article-summary__details has-image"> <div class="kicker article-summary__kicker">Drug design, drug delivery & technologies</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/714679-more-than-100m-cells-included-in-the-human-cell-atlas">More than 100M cells included in the human cell atlas</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Nov. 21, 2024</div> <div class="author article-summary__author">By <a href="/authors/595-mar-de-miguel">Mar de Miguel</a></div> <div class="comment-count article-summary__comment-count"><a title="More than 100M cells included in the human cell atlas" class="more" href="https://www.bioworld.com/articles/714679-more-than-100m-cells-included-in-the-human-cell-atlas#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">An international consortium of thousands of scientists is creating the Human Cell Atlas, a three-dimensional map of all the cells in the body. The goal is to understand all the cells that make up human tissues, organs and systems, which will enable multiple medical applications. This collection of cell maps is openly available for navigation at single-cell resolution, identified through omics analyses that reveal the tridimensional distribution of each cell.<br /></div><a title="More than 100M cells included in the human cell atlas" class="more" href="https://www.bioworld.com/articles/714679-more-than-100m-cells-included-in-the-human-cell-atlas">Read More</a> </div> </article> <article class="record article-summary "> <div class="article-summary__details "> <div class="kicker article-summary__kicker">Respiratory</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/714533-roche-identifies-new-nlrp3-inflammasome-inhibitors">Roche identifies new NLRP3 inflammasome inhibitors</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Nov. 18, 2024</div> <div class="comment-count article-summary__comment-count"><a title="Roche identifies new NLRP3 inflammasome inhibitors" class="more" href="https://www.bioworld.com/articles/714533-roche-identifies-new-nlrp3-inflammasome-inhibitors#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have patented oxazolo[4,5-B]pyrazine and oxazolo[4,5-B]pyridine derivatives acting as NLRP3 inflammasome inhibitors and reported to be useful for the treatment of asthma, chronic obstructive pulmonary disease and cardiovascular disorders.<br /></div><a title="Roche identifies new NLRP3 inflammasome inhibitors" class="more" href="https://www.bioworld.com/articles/714533-roche-identifies-new-nlrp3-inflammasome-inhibitors">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="Bioversys joins RespiriNTM program to advance efforts for NTM pulmonary disease" class="url" rel="" target="" href="https://www.bioworld.com/articles/713640-bioversys-joins-respirintm-program-to-advance-efforts-for-ntm-pulmonary-disease"><img width="650" height="488" alt="Digital lungs illustration" title="Digital lungs illustration" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Respiratory/Lungs-wireframe-illustration.png?height=488&t=1659647698&width=650" /></a></div> <div class="article-summary__details has-image"> <div class="kicker article-summary__kicker">Infection</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/713640-bioversys-joins-respirintm-program-to-advance-efforts-for-ntm-pulmonary-disease">Bioversys joins RespiriNTM program to advance efforts for NTM pulmonary disease</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Oct. 22, 2024</div> <div class="comment-count article-summary__comment-count"><a title="Bioversys joins RespiriNTM program to advance efforts for NTM pulmonary disease" class="more" href="https://www.bioworld.com/articles/713640-bioversys-joins-respirintm-program-to-advance-efforts-for-ntm-pulmonary-disease#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Bioversys AG has joined the EU-funded RespiriNTM program that is exploring multiple approaches to determine new targets for antimycobacterial compounds, define and optimize novel inhibitors and advance these through the process of hit-to-lead up until first-in-human trials.<br /></div><a title="Bioversys joins RespiriNTM program to advance efforts for NTM pulmonary disease" class="more" href="https://www.bioworld.com/articles/713640-bioversys-joins-respirintm-program-to-advance-efforts-for-ntm-pulmonary-disease">Read More</a> </div> </article> <article class="record article-summary "> <div class="article-summary__details "> <div class="kicker article-summary__kicker">Respiratory</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/713616-university-of-virginia-and-virginia-tech-patent-describes-spns2-inhibitors">University of Virginia and Virginia Tech patent describes SPNS2 inhibitors</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Oct. 21, 2024</div> <div class="comment-count article-summary__comment-count"><a title="University of Virginia and Virginia Tech patent describes SPNS2 inhibitors" class="more" href="https://www.bioworld.com/articles/713616-university-of-virginia-and-virginia-tech-patent-describes-spns2-inhibitors#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">The University of Virginia and Virginia Tech Intellectual Properties Inc. have patented protein spinster homolog 2 (SPNS2) inhibitors reported to be useful for the treatment of asthma, multiple sclerosis, chronic kidney disease and metastatic cancer.<br /></div><a title="University of Virginia and Virginia Tech patent describes SPNS2 inhibitors" class="more" href="https://www.bioworld.com/articles/713616-university-of-virginia-and-virginia-tech-patent-describes-spns2-inhibitors">Read More</a> </div> </article> <article class="record article-summary "> <div class="article-summary__details "> <div class="kicker article-summary__kicker">Respiratory</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/713317-kymeras-oral-stat-degrader-kt-621-gains-ind-clearance-from-fda">Kymera’s oral STAT degrader KT-621 gains IND clearance from FDA</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Oct. 10, 2024</div> <div class="comment-count article-summary__comment-count"><a title="Kymera’s oral STAT degrader KT-621 gains IND clearance from FDA" class="more" href="https://www.bioworld.com/articles/713317-kymeras-oral-stat-degrader-kt-621-gains-ind-clearance-from-fda#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Kymera Therapeutics Inc. has received IND clearance from the FDA for KT-621, an investigational first-in-class, once-daily, oral STAT6 degrader.<br /></div><a title="Kymera’s oral STAT degrader KT-621 gains IND clearance from FDA" class="more" href="https://www.bioworld.com/articles/713317-kymeras-oral-stat-degrader-kt-621-gains-ind-clearance-from-fda">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="MEK1/2 inhibitor shows antibacterial and anti-inflammatory effects" class="url" rel="" target="" href="https://www.bioworld.com/articles/713193-mek1-2-inhibitor-shows-antibacterial-and-anti-inflammatory-effects"><img width="650" height="488" alt="Bacteria in petri dishes" title="Bacteria in petri dishes" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Bacteria-in-petri-dishes.png?height=488&t=1588871116&width=650" /></a></div> <div class="article-summary__details has-image"> <div class="kicker article-summary__kicker">Infection</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/713193-mek1-2-inhibitor-shows-antibacterial-and-anti-inflammatory-effects">MEK1/2 inhibitor shows antibacterial and anti-inflammatory effects</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Oct. 7, 2024</div> <div class="comment-count article-summary__comment-count"><a title="MEK1/2 inhibitor shows antibacterial and anti-inflammatory effects" class="more" href="https://www.bioworld.com/articles/713193-mek1-2-inhibitor-shows-antibacterial-and-anti-inflammatory-effects#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">It was hypothesized that the MEK1/2 inhibitor ATR-002 could reduce inflammation and clear <em>Staphylococcus aureus</em> infection during cystic fibrosis, thus potentially showing a dual effect.<br /></div><a title="MEK1/2 inhibitor shows antibacterial and anti-inflammatory effects" class="more" href="https://www.bioworld.com/articles/713193-mek1-2-inhibitor-shows-antibacterial-and-anti-inflammatory-effects">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="LY6E and TCN2, new diagnostic biomarkers and therapeutic targets for RSV infection" class="url" rel="" target="" href="https://www.bioworld.com/articles/713186-ly6e-and-tcn2-new-diagnostic-biomarkers-and-therapeutic-targets-for-rsv-infection"><img width="650" height="488" alt="Scanning electron micrograph of human RSV virions" title="Scanning electron micrograph of human RSV virions" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-library/RSV.jpg?height=488&t=1728311011&width=650" /></a></div> <div class="article-summary__details has-image"> <div class="kicker article-summary__kicker">Biomarkers</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/713186-ly6e-and-tcn2-new-diagnostic-biomarkers-and-therapeutic-targets-for-rsv-infection">LY6E and TCN2, new diagnostic biomarkers and therapeutic targets for RSV infection</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Oct. 7, 2024</div> <div class="comment-count article-summary__comment-count"><a title="LY6E and TCN2, new diagnostic biomarkers and therapeutic targets for RSV infection" class="more" href="https://www.bioworld.com/articles/713186-ly6e-and-tcn2-new-diagnostic-biomarkers-and-therapeutic-targets-for-rsv-infection#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Investigators at Wuxi No. 2 Peoples Hospital and affiliated organizations conducted studies to identify novel effective biomarkers for early-stage pediatric respiratory syncytial virus (RSV) infection (EPR).<br /></div><a title="LY6E and TCN2, new diagnostic biomarkers and therapeutic targets for RSV infection" class="more" href="https://www.bioworld.com/articles/713186-ly6e-and-tcn2-new-diagnostic-biomarkers-and-therapeutic-targets-for-rsv-infection">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="Splisense’s SPL5AC restores mucus viscoelasticity and lung clearance in cystic fibrosis" class="url" rel="" target="" href="https://www.bioworld.com/articles/713114-splisenses-spl5ac-restores-mucus-viscoelasticity-and-lung-clearance-in-cystic-fibrosis"><img width="650" height="488" alt="Lungs anatomy" title="Lungs anatomy" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Respiratory/Lungs-anatomy.jpg?height=488&t=1691698481&width=650" /></a></div> <div class="article-summary__details has-image"> <div class="kicker article-summary__kicker">Respiratory</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/713114-splisenses-spl5ac-restores-mucus-viscoelasticity-and-lung-clearance-in-cystic-fibrosis">Splisense’s SPL5AC restores mucus viscoelasticity and lung clearance in cystic fibrosis</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Oct. 4, 2024</div> <div class="comment-count article-summary__comment-count"><a title="Splisense’s SPL5AC restores mucus viscoelasticity and lung clearance in cystic fibrosis" class="more" href="https://www.bioworld.com/articles/713114-splisenses-spl5ac-restores-mucus-viscoelasticity-and-lung-clearance-in-cystic-fibrosis#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">As in other muco-obstructive diseases, the airways in cystic fibrosis (CF) are characterized by goblet cell and glandular hyperplasia, with overproduction of mucins MUC5 and MUC5AC, resulting in viscous mucus, respiratory blockade and recurrent infections and inflammation.<br /></div><a title="Splisense’s SPL5AC restores mucus viscoelasticity and lung clearance in cystic fibrosis" class="more" href="https://www.bioworld.com/articles/713114-splisenses-spl5ac-restores-mucus-viscoelasticity-and-lung-clearance-in-cystic-fibrosis">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="Inhaled mRNA-based therapy rescues CFTR function" class="url" rel="" target="" href="https://www.bioworld.com/articles/713088-inhaled-mrna-based-therapy-rescues-cftr-function"><img width="650" height="488" alt="mRNA on digital background" title="mRNA on digital background" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/mRNA.png?height=488&t=1649194570&width=650" /></a></div> <div class="article-summary__details has-image"> <div class="kicker article-summary__kicker">Respiratory</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/713088-inhaled-mrna-based-therapy-rescues-cftr-function">Inhaled mRNA-based therapy rescues CFTR function</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Oct. 3, 2024</div> <div class="comment-count article-summary__comment-count"><a title="Inhaled mRNA-based therapy rescues CFTR function" class="more" href="https://www.bioworld.com/articles/713088-inhaled-mrna-based-therapy-rescues-cftr-function#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">The development of cystic fibrosis transmembrane conductance regulator (CFTR) modulators has significantly improved the therapeutic scenario for CF patients in the past decade. However, around 10% of patients harboring nonsense and splice-site mutations are nonresponsive to CFTR modulators.<br /></div><a title="Inhaled mRNA-based therapy rescues CFTR function" class="more" href="https://www.bioworld.com/articles/713088-inhaled-mrna-based-therapy-rescues-cftr-function">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="Preclinical profiling of Splisense’s inhaled antisense oligonucleotide" class="url" rel="" target="" href="https://www.bioworld.com/articles/713083-preclinical-profiling-of-splisenses-inhaled-antisense-oligonucleotide"><img width="650" height="488" alt="Lungs" title="Lungs" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Respiratory/Lungs2.png?height=488&t=1589292447&width=650" /></a></div> <div class="article-summary__details has-image"> <div class="kicker article-summary__kicker">Respiratory</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/713083-preclinical-profiling-of-splisenses-inhaled-antisense-oligonucleotide">Preclinical profiling of Splisense’s inhaled antisense oligonucleotide</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Oct. 3, 2024</div> <div class="comment-count article-summary__comment-count"><a title="Preclinical profiling of Splisense’s inhaled antisense oligonucleotide" class="more" href="https://www.bioworld.com/articles/713083-preclinical-profiling-of-splisenses-inhaled-antisense-oligonucleotide#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Researchers from Splisense Ltd. and affiliated organizations recently reported preclinical data for SPL-84, an inhaled antisense oligonucleotide drug candidate being developed for the treatment of patients with cystic fibrosis carrying the 3849 +10 kb C-to-T (3849) mutation.<br /></div><a title="Preclinical profiling of Splisense’s inhaled antisense oligonucleotide" class="more" href="https://www.bioworld.com/articles/713083-preclinical-profiling-of-splisenses-inhaled-antisense-oligonucleotide">Read More</a> </div> </article> </div> <div class="pager"> <div role="navigation" aria-label="Pagination" class="pagination"><span class="previous_page disabled" aria-disabled="true">Previous</span> <em class="current" aria-label="Page 1" aria-current="page">1</em> <a rel="next" aria-label="Page 2" href="/articles/topic/520,263?page=2">2</a> <a aria-label="Page 3" href="/articles/topic/520,263?page=3">3</a> <a aria-label="Page 4" href="/articles/topic/520,263?page=4">4</a> <a aria-label="Page 5" href="/articles/topic/520,263?page=5">5</a> <a aria-label="Page 6" href="/articles/topic/520,263?page=6">6</a> <a aria-label="Page 7" href="/articles/topic/520,263?page=7">7</a> <a aria-label="Page 8" href="/articles/topic/520,263?page=8">8</a> <a aria-label="Page 9" href="/articles/topic/520,263?page=9">9</a> <span 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