Genetic Immunity - Infectious Diseases

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This form of immunity is inherited and provides protection against specific pathogens without prior exposure or vaccination.</div><div> <a href="https://infect.blog/knowledgebase/how-does-genetic-immunity-work" title="How Does Genetic Immunity Work?"><h3>How Does Genetic Immunity Work?</h3></a> Genetic immunity operates through various mechanisms, including the presence of specific genes that either enhance the immune response or inhibit the ability of pathogens to infect host cells. For example, certain genetic mutations can alter cell surface receptors, making it difficult for viruses to enter cells.</div><div> <h3>Examples of Genetic Immunity</h3> One well-known example is the mutation in the CCR5 gene, which provides resistance to HIV infection. Individuals with two copies of this mutation (homozygous) are highly resistant to HIV. Another example is the sickle cell trait, which offers a protective advantage against malaria.</div><div> <h3>The Role of HLA Genes</h3> Human Leukocyte Antigen (HLA) genes play a crucial role in genetic immunity. These genes are responsible for the regulation of the immune system. Variations in HLA genes can influence an individual's susceptibility to infectious diseases like tuberculosis and hepatitis.</div><div> <h3>Genetic Immunity and Epidemiology</h3> Understanding genetic immunity can help in the field of epidemiology by identifying populations that are at higher or lower risk for certain infectious diseases. This knowledge can inform public health strategies and vaccination programs.</div><div> <h3>Limitations and Ethical Considerations</h3> While genetic immunity offers promising insights, it also raises ethical questions. For instance, should genetic testing for susceptibility to infectious diseases become a standard practice? Additionally, focusing too much on genetics may overlook environmental and social factors that contribute to disease spread.</div><div> <h3>Future Directions</h3> Advances in genomics and biotechnology hold the potential to harness genetic immunity for developing new treatments and vaccines. For example, CRISPR technology could be used to edit genes and enhance resistance to infectious diseases.</div><div> <h3>Conclusion</h3> Genetic immunity is a fascinating and complex field that bridges genetics and infectious diseases. While it offers significant promise for understanding and combating infections, it also requires careful consideration of its ethical and practical implications.</div></div> </div> <div id="recent_papers"> <br><hr /><br><h2 class="heading1">Relevant Publications</h2> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/39192124" target='_blank' title="DNA PAMPs as Molecular Tools for the cGAS-STING Signaling Pathways.">DNA PAMPs as Molecular Tools for the cGAS-STING Signaling Pathways.</a> </div> <p><strong>Issue Release:</strong> 2025</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/39192118" target='_blank' title="CRISPR-Mediated Library Screening of Gene-Knockout Cell Lines for Investigating Antiviral Innate Immunity.">CRISPR-Mediated Library Screening of Gene-Knockout Cell Lines for Investigating Antiviral Innate Immunity.</a> </div> <p><strong>Issue Release:</strong> 2025</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/39192117" target='_blank' title="CRISPR-Mediated Viral Gene Knockout to Investigate Viral Evasion of Antiviral Innate Immunity.">CRISPR-Mediated Viral Gene Knockout to Investigate Viral Evasion of Antiviral Innate Immunity.</a> </div> <p><strong>Issue Release:</strong> 2025</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/39192133" target='_blank' title="Zebrafish as a Model for Investigating Antiviral Innate Immunity.">Zebrafish as a Model for Investigating Antiviral Innate Immunity.</a> </div> <p><strong>Issue Release:</strong> 2025</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/39192135" target='_blank' title="Identifying a Gene Deficiency in the Antiviral Innate Immune Signaling Pathway.">Identifying a Gene Deficiency in the Antiviral Innate Immune Signaling Pathway.</a> </div> <p><strong>Issue Release:</strong> 2025</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38839914" target='_blank' title="HIF-1伪 and MIF enhance neutrophil-driven type 3 immunity and chondrogenesis in a murine spondyloarthritis model.">HIF-1伪 and MIF enhance neutrophil-driven type 3 immunity and chondrogenesis in a murine spondyloarthritis model.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38840048" target='_blank' title="Whole-genome sequencing reveals genomic diversity and selection signatures in Xia\'nan cattle.">Whole-genome sequencing reveals genomic diversity and selection signatures in Xia\'nan cattle.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38849728" target='_blank' title="Genomic exploration of the fermented meat isolate Staphylococcus shinii IMDO-S216 with a focus on competitiveness-enhancing secondary metabolites.">Genomic exploration of the fermented meat isolate Staphylococcus shinii IMDO-S216 with a focus on competitiveness-enhancing secondary metabolites.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38838930" target='_blank' title="Two novel compound heterozygous loss-of-function mutations cause fetal IRAK-4 deficiency presenting with Pseudomonas Aeruginosa sepsis.">Two novel compound heterozygous loss-of-function mutations cause fetal IRAK-4 deficiency presenting with Pseudomonas Aeruginosa sepsis.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38879301" target='_blank' title="Effects of aflatoxin B on metabolism- and immunity-related gene expression in Hermetia illucens L. (Diptera: Stratiomyidae).">Effects of aflatoxin B on metabolism- and immunity-related gene expression in Hermetia illucens L. (Diptera: Stratiomyidae).</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38878482" target='_blank' title="Sonocatalytic oncolysis microbiota curb intrinsic microbiota lactate metabolism and blockade CD24-Siglec10 immune escape to revitalize immunological surveillance.">Sonocatalytic oncolysis microbiota curb intrinsic microbiota lactate metabolism and blockade CD24-Siglec10 immune escape to revitalize immunological surveillance.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38852888" target='_blank' title="Gut dysbiosis impacts the immune system and promotes prostate cancer.">Gut dysbiosis impacts the immune system and promotes prostate cancer.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38907887" target='_blank' title="HLA Genes: A Hallmark of Functional Genetic Variation and Complex Evolution.">HLA Genes: A Hallmark of Functional Genetic Variation and Complex Evolution.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38898675" target='_blank' title="Significant Correlation Between Cutaneous Abundance of Streptococcus and Psoriasis Severity in Patients with FBXL19 Gene Variants.">Significant Correlation Between Cutaneous Abundance of Streptococcus and Psoriasis Severity in Patients with FBXL19 Gene Variants.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38942798" target='_blank' title="PIKfyve, expressed by CD11c-positive cells, controls tumor immunity.">PIKfyve, expressed by CD11c-positive cells, controls tumor immunity.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38953007" target='_blank' title="The rapidly changing field of predictive biomarkers of non-small cell lung cancer.">The rapidly changing field of predictive biomarkers of non-small cell lung cancer.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38952870" target='_blank' title="Coexistence of nonfluorescent chromoproteins and fluorescent proteins in massive spp. corals manifesting a pink pigmentation response.">Coexistence of nonfluorescent chromoproteins and fluorescent proteins in massive spp. corals 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