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class="vector-toc-numb">3.1</span> <span>Culture of mammalian eggs and embryos</span> </div> </a> <ul id="toc-Culture_of_mammalian_eggs_and_embryos-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Stem_cells_injection_into_mouse_embryos_produce_the_first_prototype_transgenic_animal" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Stem_cells_injection_into_mouse_embryos_produce_the_first_prototype_transgenic_animal"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2</span> <span>Stem cells injection into mouse embryos produce the first prototype transgenic animal</span> </div> </a> <ul id="toc-Stem_cells_injection_into_mouse_embryos_produce_the_first_prototype_transgenic_animal-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Transgenesis_and_the_giant_mouse" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Transgenesis_and_the_giant_mouse"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.3</span> <span>Transgenesis and the giant mouse</span> </div> </a> <ul id="toc-Transgenesis_and_the_giant_mouse-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Modifying_genes_in_sperm" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Modifying_genes_in_sperm"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.4</span> <span>Modifying genes in sperm</span> </div> </a> <ul id="toc-Modifying_genes_in_sperm-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Major_scientific_recognition" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Major_scientific_recognition"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Major scientific recognition</span> </div> </a> <ul id="toc-Major_scientific_recognition-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Academic_career" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Academic_career"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Academic career</span> </div> </a> <ul id="toc-Academic_career-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Personal_history" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Personal_history"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Personal history</span> </div> </a> <ul id="toc-Personal_history-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Awards_and_honors" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Awards_and_honors"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Awards and honors</span> </div> </a> <ul id="toc-Awards_and_honors-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-In_popular_culture" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#In_popular_culture"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>In popular culture</span> </div> </a> <ul id="toc-In_popular_culture-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">10</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" title="Table of Contents" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span 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Brinster</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. 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Brinster – German" lang="de" hreflang="de" data-title="Ralph L. 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dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">American geneticist</div> <p class="mw-empty-elt"> </p> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox biography vcard"><tbody><tr><th colspan="2" class="infobox-above" style="font-size:125%;"><div class="fn">Ralph L. Brinster</div></th></tr><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Ralph_L._Brinster.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d1/Ralph_L._Brinster.jpg/220px-Ralph_L._Brinster.jpg" decoding="async" width="220" height="325" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d1/Ralph_L._Brinster.jpg/330px-Ralph_L._Brinster.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d1/Ralph_L._Brinster.jpg/440px-Ralph_L._Brinster.jpg 2x" data-file-width="524" data-file-height="774" /></a></span><div class="infobox-caption">Brinster in October 2011</div></td></tr><tr><th scope="row" class="infobox-label">Born</th><td class="infobox-data"><span style="display:none"> (<span class="bday">1932-03-10</span>) </span>March 10, 1932<span class="noprint ForceAgeToShow"> (age 92)</span><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><br /><div style="display:inline" class="birthplace"><a href="/wiki/Montclair,_New_Jersey" title="Montclair, New Jersey">Montclair, New Jersey</a></div></td></tr><tr><th scope="row" class="infobox-label">Nationality</th><td class="infobox-data category"><a href="/wiki/United_States" title="United States">American</a></td></tr><tr><th scope="row" class="infobox-label">Alma mater</th><td class="infobox-data"><a href="/wiki/Rutgers_University" title="Rutgers University">Rutgers University</a> <small>(B.S., 1953)</small><br /><a href="/wiki/University_of_Pennsylvania" title="University of Pennsylvania">University of Pennsylvania</a> <small>(V.M.D., 1960) (Ph.D., 1964)</small></td></tr><tr><th scope="row" class="infobox-label">Awards</th><td class="infobox-data"><a href="/wiki/Grand_Prix_Charles-Leopold_Mayer" title="Grand Prix Charles-Leopold Mayer">Grand Prix Charles-Leopold Mayer</a>, <i><a href="/wiki/France" title="France">FRA</a></i><br /><a href="/wiki/March_of_Dimes_Prize_in_Developmental_Biology" title="March of Dimes Prize in Developmental Biology">March of Dimes Prize in Developmental Biology</a>, <i><a href="/wiki/United_States" title="United States">USA</a></i><br /><a href="/wiki/Wolf_Prize_in_Medicine" title="Wolf Prize in Medicine">Wolf Prize in Medicine</a>, <i><a href="/wiki/Israel" title="Israel">ISR</a></i><br /><a href="/wiki/Gairdner_Foundation_International_Award" class="mw-redirect" title="Gairdner Foundation International Award">Gairdner Foundation International Award</a>, <i><a href="/wiki/Canada" title="Canada">CAN</a></i><br /><a href="/wiki/National_Medal_of_Science" title="National Medal of Science">National Medal of Science</a>, <i><a href="/wiki/United_States" title="United States">USA</a></i></td></tr><tr><td colspan="2" class="infobox-full-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><b>Scientific career</b></td></tr><tr><th scope="row" class="infobox-label">Fields</th><td class="infobox-data category"><a href="/wiki/Genetics" title="Genetics">Genetics</a>; <a href="/wiki/Embryology" title="Embryology">Embryology</a>; <a href="/wiki/Genetic_engineering" title="Genetic engineering">Genetic engineering</a></td></tr><tr><th scope="row" class="infobox-label">Institutions</th><td class="infobox-data"><a href="/wiki/University_of_Pennsylvania_School_of_Veterinary_Medicine" title="University of Pennsylvania School of Veterinary Medicine">University of Pennsylvania School of Veterinary Medicine</a></td></tr><tr style="display:none"><td colspan="2"> </td></tr></tbody></table> <p><b>Ralph Lawrence Brinster</b><sup id="cite_ref-AAAS_2-0" class="reference"><a href="#cite_note-AAAS-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> (born March 10, 1932) is an American <a href="/wiki/Geneticist" title="Geneticist">geneticist</a>, <a href="/wiki/National_Medal_of_Science" title="National Medal of Science">National Medal of Science</a> laureate, and <a href="/wiki/Richard_King_Mellon" title="Richard King Mellon">Richard King Mellon</a> Professor of Reproductive Physiology at the <a href="/wiki/University_of_Pennsylvania_School_of_Veterinary_Medicine" title="University of Pennsylvania School of Veterinary Medicine">School of Veterinary Medicine, University of Pennsylvania.</a><sup id="cite_ref-dvm_3-0" class="reference"><a href="#cite_note-dvm-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Early_life_and_education">Early life and education</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ralph_L._Brinster&action=edit&section=1" title="Edit section: Early life and education"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Ralph L. Brinster grew up on a small farm in <a href="/wiki/Cedar_Grove,_New_Jersey" title="Cedar Grove, New Jersey">Cedar Grove, New Jersey</a> where his parents raised <a href="/wiki/Purebred" title="Purebred">purebred</a> animals.<sup id="cite_ref-dvm_3-1" class="reference"><a href="#cite_note-dvm-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> He studied animal science as an undergraduate at the Cook School of Agriculture, <a href="/wiki/Rutgers_University" title="Rutgers University">Rutgers University</a>, New Brunswick, NJ and completed his B.S. in 1953. While he was in college, the Korean Conflict began, and he volunteered for service. He was a USAF second lieutenant in Korea during the last year of the combat period and after being assigned to the U.S. Army was stationed north of Seoul with an Army Battalion. He returned from military service and earned his V.M.D. (<i>Veterinariae Medicinae Doctoris</i>) (1960) and his Ph.D. in <a href="/wiki/Physiology" title="Physiology">Physiology</a> (1964) from the <a href="/wiki/University_of_Pennsylvania" title="University of Pennsylvania">University of Pennsylvania</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Research_impact">Research impact</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ralph_L._Brinster&action=edit&section=2" title="Edit section: Research impact"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Ralph Brinster is acknowledged as one of the seminal founders of the field of <a href="/wiki/Mammal" title="Mammal">mammalian</a> <a href="/wiki/Transgenesis" class="mw-redirect" title="Transgenesis">transgenesis</a>.<sup id="cite_ref-:1_4-0" class="reference"><a href="#cite_note-:1-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:2_5-0" class="reference"><a href="#cite_note-:2-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:3_6-0" class="reference"><a href="#cite_note-:3-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> He is known throughout the scientific community for his revolutionary research in early embryo development, <a href="/wiki/Cellular_differentiation" title="Cellular differentiation">embryonic-cell differentiation</a>, mechanisms of <a href="/wiki/Gene_control" class="mw-redirect" title="Gene control">gene control</a>, and <a href="/wiki/Stem_cell" title="Stem cell">stem cell</a> biology.<sup id="cite_ref-:2_5-1" class="reference"><a href="#cite_note-:2-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_7-0" class="reference"><a href="#cite_note-:4-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:5_8-0" class="reference"><a href="#cite_note-:5-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Brinster's contributions to our knowledge about and understanding of the germline of mammals have been truly extraordinary and have been recognized at the highest level. There is no scientist that has contributed more to the understanding of mammalian genetic modification and germ cells -- the most important cells to the individual and survival of any species. In 2006, Brinster received a Canada Gairdner Foundation International Award for pioneering discoveries in germline modification in mammals.<sup id="cite_ref-:2_5-2" class="reference"><a href="#cite_note-:2-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> In part the citation read, “his range of contributions is unmatched in the field”. Germline cells are at the foundation of species continuity and are responsible for propagation of individuals of varying genetic content that is critical for evolutionary competition. Specifically, the genetic composition of these cells is the essence of their importance. Brinster's seminal studies on mammalian egg manipulation strategies and his pioneering research on spermatogonial stem cells are today the foundation for all studies in this field, including the controversial potential for modifying the human germline. </p><p>Some have suggested that “the experimental genetic manipulation of the animal germline initially by pronuclear injection of cloned DNA into zygotes represents one of the most significant milestones in the history of human civilization," Behringer et al, in Manipulating the Mouse Embryo (Cold Spring Harbor Laboratory Press, pg14, 2014). Germline modification has existed for hundreds of millions of years and has contributed to the evolution of species through interaction with their environment. Purposeful germline modification by man began about 10,000 years ago in the fertile crescent of southwest Asia with domestication of plants and animals, giving rise to agriculture and modern civilization. The initial concept of domesticating wild species may be viewed as the first of four critical advances in man’s intervention in evolutionary germline modification and is considered by many as representing the beginning of modern human history. The subsequent realization that selecting and breeding desirable phenotypes would lead to valuable alterations in domesticated species symbolizes the second advance. The identification and characterization of hereditary elements, which began with the studies of Mendel and continues today with the sequencing of genomes, represents the third significant development. These three conceptual advances are often considered to be the foundation of agriculture and modern civilization. Experimental addition or modification of individual DNA sequences and genes in the germline, known as transgenesis, exemplifies a fourth unique conceptual advance in man’s purposeful modification of the germline. Thus, the generation of transgenic animals is an extraordinary, creative development in man’s historical interaction with other species and of enormous importance in biology and medicine (see NICHD 2003 Hall of Honor and 2012 Colloquium External links below). </p><p>During the 1960s, Brinster pioneered the development of techniques to manipulate <a href="/wiki/Mouse" title="Mouse">mouse</a> embryos, and his techniques have made the mouse the major genetic model for understanding the basis of human biology and disease.<sup id="cite_ref-:2_5-3" class="reference"><a href="#cite_note-:2-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:3_6-1" class="reference"><a href="#cite_note-:3-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> His research has provided the experimental foundation for progress in <a href="/wiki/Germline" title="Germline">germline</a> genetic modification in a range of species, which has generated a revolution in biology, medicine, and agriculture.<sup id="cite_ref-:4_7-1" class="reference"><a href="#cite_note-:4-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>In July 2024, Dr. Brinster had 411 total publications, approximately 322 are in peer-reviewed journals and 89 are chapters/reviews. Included in the publications are: 30 in Nature, 18 in Cell, 13 in Science, and 35 in Proc. Natl. Acad. Sci. </p><p>His research contribution/impact is ranked 1st of 173,000 contributors in Veterinary Medicine in the world and 8th of one million contributors in Agriculture and Natural Resources in the world in <a rel="nofollow" class="external text" href="https://scholargps.com/scholars/87162810610607/ralph-l-brinster">Scholars GPS</a> with an <a href="/wiki/H-index" title="H-index">h-index</a> = 153. </p><p>He is ranked #128 in the world and # 96 in the United States among top scientists for 2024 in <a rel="nofollow" class="external text" href="https://research.com/u/ralph-l-brinster">Research.com</a> with a D-index (Discipline h-index) = 152. </p> <div class="mw-heading mw-heading2"><h2 id="Research_history">Research history</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ralph_L._Brinster&action=edit&section=3" title="Edit section: Research history"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Brinster_Mouse_Egg_Culture_1963_slides.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/45/Brinster_Mouse_Egg_Culture_1963_slides.png/220px-Brinster_Mouse_Egg_Culture_1963_slides.png" decoding="async" width="220" height="233" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/45/Brinster_Mouse_Egg_Culture_1963_slides.png/330px-Brinster_Mouse_Egg_Culture_1963_slides.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/45/Brinster_Mouse_Egg_Culture_1963_slides.png/440px-Brinster_Mouse_Egg_Culture_1963_slides.png 2x" data-file-width="1060" data-file-height="1125" /></a><figcaption>Fig. 1. Mouse egg culture. The image shows the dish in which embryos are cultured and the progression of two-cell embryos to a hollow structure known as the blastocyst.<sup id="cite_ref-:7_9-0" class="reference"><a href="#cite_note-:7-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></figcaption></figure> <div class="mw-heading mw-heading3"><h3 id="Culture_of_mammalian_eggs_and_embryos">Culture of mammalian eggs and embryos</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ralph_L._Brinster&action=edit&section=4" title="Edit section: Culture of mammalian eggs and embryos"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>While a Ph.D. candidate in the 1960s, Brinster developed the first reliable <i><a href="/wiki/In_vitro" title="In vitro">in vitro</a></i> culture system for early mammalian <a href="/wiki/Embryo" title="Embryo">embryos</a>. His initial studies were on fertilized eggs of the mouse. In 1963, he described a culture method consisting of micro drops of medium under oil, which remains the primary culture technique for mammalian eggs of all species, including human eggs during in vitro fertilization. During the next 10 years, Brinster studied many aspects of mouse egg metabolism and defined characteristics common to eggs of all mammalian species. From these studies he developed a culture medium and embryo manipulation strategies that are the basis of all egg culture media and manipulation methods in use today. He published more than 60 papers in the general area of egg metabolism and culture and is the scientist who laid the foundation for subsequent research involving mammalian egg culture. His studies provided a reliable method to manipulate all stages of preimplantation development in the mouse and other mammalian species (See Figure 1).<sup id="cite_ref-:6_10-0" class="reference"><a href="#cite_note-:6-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:7_9-1" class="reference"><a href="#cite_note-:7-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>These techniques have been conserved to the present day and form the foundation for all experimentation with the mammalian embryo - including transgenic animals, embryonic stem cell research, human and mammalian <i>in vitro</i> fertilization, mammalian cloning, and <a href="/wiki/Gene_knockout" title="Gene knockout">knockout</a> technology. </p><p>His <i>in vitro</i> culture and egg manipulation strategies have directly enabled foundational techniques in modern science such as embryo splitting, intracytoplasmic sperm injection, nuclear transplantation, and mitochondrial transplantation into eggs, among others, which occur <i>in vitro</i> using methods virtually unchanged since they were introduced by Brinster. </p><p>This "Brinster Method" of embryo manipulation is so ubiquitous in modern biology that other scientists rarely cite the work in current publications.<sup id="cite_ref-:6_10-1" class="reference"><a href="#cite_note-:6-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:7_9-2" class="reference"><a href="#cite_note-:7-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Mouse_-_handwriting_on_back.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/Mouse_-_handwriting_on_back.jpg/220px-Mouse_-_handwriting_on_back.jpg" decoding="async" width="220" height="156" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/Mouse_-_handwriting_on_back.jpg/330px-Mouse_-_handwriting_on_back.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/00/Mouse_-_handwriting_on_back.jpg/440px-Mouse_-_handwriting_on_back.jpg 2x" data-file-width="8141" data-file-height="5788" /></a><figcaption>Fig. 2. Chimeric mouse. This mouse resulted from a blastocyst, which normally would produce a white mouse, that was injected with teratocarcinoma cells from a brown mouse. The dark stripes on the mouse represent the contribution of the foreign brown-type cells.<sup id="cite_ref-:14_11-0" class="reference"><a href="#cite_note-:14-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup></figcaption></figure> <div class="mw-heading mw-heading3"><h3 id="Stem_cells_injection_into_mouse_embryos_produce_the_first_prototype_transgenic_animal">Stem cells injection into mouse embryos produce the first prototype transgenic animal</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ralph_L._Brinster&action=edit&section=5" title="Edit section: Stem cells injection into mouse embryos produce the first prototype transgenic animal"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Brinster used the foundation of his culture and manipulation strategies to study techniques to alter the genetic makeup of developing embryos and their germ cells. In the early 1970s, he injected stem cells into embryos (blastocysts) in a series of imaginative experiments which were of enormous importance and changed the way scientists thought about the possibility of modifying genes in the germline. He was the first scientist to demonstrate that foreign teratocarcinoma cells could combine with native blastocyst cells to form adult "chimeric" mice, demonstrating the feasibility of this novel approach to change the genetic character of mice (Fig. 2).<sup id="cite_ref-:14_11-1" class="reference"><a href="#cite_note-:14-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> The introduction of foreign cells and new genes into these chimeric mice generated the first prototype transgenic animals.<sup id="cite_ref-:5_8-1" class="reference"><a href="#cite_note-:5-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> In addition, this discovery stimulated the search for embryonic stem cells and ultimately led to the development of the "knock-out mouse". </p> <figure class="mw-default-size mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:Giant-Super_Mouse_and_Normal_Size_Mouse.tif" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/80/Giant-Super_Mouse_and_Normal_Size_Mouse.tif/lossy-page1-220px-Giant-Super_Mouse_and_Normal_Size_Mouse.tif.jpg" decoding="async" width="220" height="177" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/80/Giant-Super_Mouse_and_Normal_Size_Mouse.tif/lossy-page1-330px-Giant-Super_Mouse_and_Normal_Size_Mouse.tif.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/80/Giant-Super_Mouse_and_Normal_Size_Mouse.tif/lossy-page1-440px-Giant-Super_Mouse_and_Normal_Size_Mouse.tif.jpg 2x" data-file-width="1469" data-file-height="1179" /></a><figcaption>Fig. 4. Giant/Super Mouse produced from growth hormone gene injection into mouse egg. The small mouse is of normal size, and the large mouse resulted from a fertilized egg injected with a growth hormone gene, as shown in figure 3 above. The injected egg was transferred to a foster mother uterus and subsequently produced the large mouse which grew twice as fast and became 50% larger. <sup id="cite_ref-:10_12-0" class="reference"><a href="#cite_note-:10-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup></figcaption></figure> <div class="mw-heading mw-heading3"><h3 id="Transgenesis_and_the_giant_mouse">Transgenesis and the giant mouse</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ralph_L._Brinster&action=edit&section=6" title="Edit section: Transgenesis and the giant mouse"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Brinster_Mouse_Egg_Microinjection.tif" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/90/Brinster_Mouse_Egg_Microinjection.tif/lossy-page1-220px-Brinster_Mouse_Egg_Microinjection.tif.jpg" decoding="async" width="220" height="318" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/90/Brinster_Mouse_Egg_Microinjection.tif/lossy-page1-330px-Brinster_Mouse_Egg_Microinjection.tif.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/90/Brinster_Mouse_Egg_Microinjection.tif/lossy-page1-440px-Brinster_Mouse_Egg_Microinjection.tif.jpg 2x" data-file-width="1314" data-file-height="1902" /></a><figcaption>Fig. 3. New gene being injected into fertilized mouse egg. The top image is a fertilized mouse egg before injection, and the bottom image is the egg following introduction of a solution containing a new gene (note the swollen pro-nuclear structure in the lower egg, which contains the chromosomes of the egg and the new gene).<sup id="cite_ref-:15_13-0" class="reference"><a href="#cite_note-:15-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup></figcaption></figure><p>Professor Brinster was the first scientist to microinject fertilized eggs with RNA and DNA, and was at the forefront of the field in applying these microinjection methods to generate transgenic mice.<sup id="cite_ref-:1_4-1" class="reference"><a href="#cite_note-:1-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:3_6-2" class="reference"><a href="#cite_note-:3-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:8_14-0" class="reference"><a href="#cite_note-:8-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:9_15-0" class="reference"><a href="#cite_note-:9-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Direct injection of fertilized mouse eggs, pioneered by Brinster, was the first approach to achieve routine experimental germline modification and served as the basis for all subsequent techniques (Fig. 3).<sup id="cite_ref-:15_13-1" class="reference"><a href="#cite_note-:15-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p><p>Brinster then collaborated with <a href="/wiki/Richard_Palmiter" title="Richard Palmiter">Richard Palmiter</a>, a prominent molecular biologist at the University of Washington, to pioneer and develop the transfer of foreign genes into mammals, and they utilized these methods to elucidate the activity and function of many genes. Their seminal experiments catalyzed a worldwide revolution in genetic engineering in the 1980s.<sup id="cite_ref-:8_14-1" class="reference"><a href="#cite_note-:8-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:9_15-1" class="reference"><a href="#cite_note-:9-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> Transgenic mice are now used every day in thousands of laboratories around the world to investigate everything from cancer biology and cardiovascular disease to hair loss and abnormal behavior. Their experiments, for the first time, showed that new genes could be introduced into the mammalian germline with the potential to increase disease resistance, enhance growth, and produce vital proteins like blood-clotting factors needed by <a href="/wiki/Hemophilia" class="mw-redirect" title="Hemophilia">hemophiliacs</a>. Perhaps their best known experiment was in generating the “Giant/Super Mouse”, which catalyzed interest within the scientific community and in the general public about the enormous potential of the transgenic technology being developed and is credited with the initiation of the genetic revolution in biology, medicine and agriculture (Fig. 4).<sup id="cite_ref-:10_12-1" class="reference"><a href="#cite_note-:10-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> In addition, they provided the first proof of expression of <a href="/wiki/Transgene" title="Transgene">transgenes</a>, the first example of cancer arising from a transgene and the first proof of the targeted integration of <a href="/wiki/DNA" title="DNA">DNA</a> by egg injection.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> Together, Brinster and Palmiter developed many of the first animal models of human disease throughout the 1980s. Their partnership also yielded the first transgenic rabbits, sheep, and pigs.<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p><p> This transcontinental collaboration constructed a body of work that formed the foundation for a generation of scientific progress in genetic modification via transgenesis, homologous recombination or "knock-out" techniques, and cloning; and the egg culture and manipulation strategies were essential for these experiments by Brinster and Palmiter, as well as for all other scientists working with eggs and embryos of all species. The egg culture and injection techniques developed by Brinster serve as the basis for the <a href="/wiki/CRISPR/Cas9" class="mw-redirect" title="CRISPR/Cas9">CRISPR/Cas9</a> system of genetic modification currently used for all types of gene changes in all species. </p><figure class="mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:GFPPupsAndTestisForWiki.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/bf/GFPPupsAndTestisForWiki.jpg/220px-GFPPupsAndTestisForWiki.jpg" decoding="async" width="220" height="312" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/bf/GFPPupsAndTestisForWiki.jpg/329px-GFPPupsAndTestisForWiki.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/bf/GFPPupsAndTestisForWiki.jpg/439px-GFPPupsAndTestisForWiki.jpg 2x" data-file-width="1200" data-file-height="1704" /></a><figcaption>Fig. 5. Top panel. Recipient mouse testis that was injected with genetically modified spermatogonial stem cells containing a reporter transgene for Green Fluorescent Protein (GFP), which will fluoresce green. Bottom Panel. The testis will produce spermatozoa that transmitted the GFP transgene to offspring.<sup id="cite_ref-:16_20-0" class="reference"><a href="#cite_note-:16-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup></figcaption></figure> <p>In short, Brinster's egg injection technique was the first used to produce transgenic animals and is now the major method for making all genetic alterations in all species. </p> <div class="mw-heading mw-heading3"><h3 id="Modifying_genes_in_sperm">Modifying genes in sperm</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ralph_L._Brinster&action=edit&section=7" title="Edit section: Modifying genes in sperm"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Brinster_Male_germline_stem_cell_transplantation.tif" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/e/ee/Brinster_Male_germline_stem_cell_transplantation.tif/lossy-page1-220px-Brinster_Male_germline_stem_cell_transplantation.tif.jpg" decoding="async" width="220" height="164" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/ee/Brinster_Male_germline_stem_cell_transplantation.tif/lossy-page1-330px-Brinster_Male_germline_stem_cell_transplantation.tif.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/ee/Brinster_Male_germline_stem_cell_transplantation.tif/lossy-page1-440px-Brinster_Male_germline_stem_cell_transplantation.tif.jpg 2x" data-file-width="2700" data-file-height="2007" /></a><figcaption>Fig. 6. Male germline stem cell transplantation. The proposed clinical application of human spermatogonial stem cells (SSCs). Before treatment for cancer by chemotherapy or irradiation, a prepubertal boy could undergo a testicular biopsy to recover SSCs. The SSCs would be cryopreserved and/or cultured to expand their number in vitro. After treatment, the SSCs would be transplanted to the patient’s testes to produce spermatozoa. A step for genetic correction to rescue a genetic disorder is possible prior to transplantation.<sup id="cite_ref-:11_21-0" class="reference"><a href="#cite_note-:11-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup></figcaption></figure> <p>In recent years, Brinster has continued to advance the field of stem cell biology by making a series of catalyzing, transformational discoveries utilizing male germline stem cells, called spermatogonial stem cells (SSCs). Spermatogonial stem cells in the testes are the only cells in the adult body that divide throughout life and transmit genes to the next generation, establishing them as a powerful resource to modify genes of any mammalian species. In elegant experiments published in 1994, Brinster demonstrated that these stem cells can be transplanted from the testis of a fertile male to the testis of an infertile male where they establish spermatogenesis and produce spermatozoa of donor haplotype (Fig. 5).<sup id="cite_ref-:16_20-1" class="reference"><a href="#cite_note-:16-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> He further demonstrated that the technique is applicable to all mammalian species examined, including humans.<sup id="cite_ref-:11_21-1" class="reference"><a href="#cite_note-:11-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> Currently, scientists are extending spermatogonial stem cell culture and transplantation to prepubertal boys being treated for cancer to preserve their fertility (Fig. 6).<sup id="cite_ref-:11_21-2" class="reference"><a href="#cite_note-:11-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> The ability to harvest, culture, genetically modify, freeze and transplant spermatogonial stem cells will not only allow sophisticated genetic modification but will make individual males biologically immortal. Moreover, current studies indicate that it soon will be possible to convert a somatic cell to a germ cell, particularly to the SSC, which will have enormous implications scientifically and in the treatment of clinically important fertility problems.<sup id="cite_ref-:16_20-2" class="reference"><a href="#cite_note-:16-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> </p><p><b>Each of these four revolutionary contributions have launched entire fields of scientific inquiry.</b> </p><p> The fundamental and enormous importance of Ralph Brinster's breakthrough experiments underlying germline modification is exemplified by the realization that no level of description of the genetic code will enable an understanding of how it functions without the ability to experimentally modify the code and study the result in vivo. These experiments on germline modification in mammals today are based on the foundational work of Brinster, including the development of egg culture and egg manipulation strategies, demonstration that the blastocyst could be colonized by foreign stem cells, the ability of eggs to survive direct injection of RNA and DNA, and methods to modify spermatogonial stem cells. Ralph Brinster's contributions in this area are without equal, and he has often been referred to as the "father of transgenesis."</p><figure typeof="mw:File/Thumb"><a href="/wiki/File:Brinster_Obama_National_Medal_of_Science_2010.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9e/Brinster_Obama_National_Medal_of_Science_2010.jpg/290px-Brinster_Obama_National_Medal_of_Science_2010.jpg" decoding="async" width="290" height="207" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9e/Brinster_Obama_National_Medal_of_Science_2010.jpg/435px-Brinster_Obama_National_Medal_of_Science_2010.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9e/Brinster_Obama_National_Medal_of_Science_2010.jpg/580px-Brinster_Obama_National_Medal_of_Science_2010.jpg 2x" data-file-width="2100" data-file-height="1500" /></a><figcaption>Professor Ralph Brinster receiving the National Medal of Science from President Barack Obama.</figcaption></figure> <figure typeof="mw:File/Thumb"><a href="/wiki/File:Elaine_Redding_Brinster_Prize_Medal.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/19/Elaine_Redding_Brinster_Prize_Medal.png/160px-Elaine_Redding_Brinster_Prize_Medal.png" decoding="async" width="160" height="317" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/19/Elaine_Redding_Brinster_Prize_Medal.png/240px-Elaine_Redding_Brinster_Prize_Medal.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/19/Elaine_Redding_Brinster_Prize_Medal.png/320px-Elaine_Redding_Brinster_Prize_Medal.png 2x" data-file-width="955" data-file-height="1890" /></a><figcaption>The Elaine Redding Brinster Prize in Science or Medicine medallion.</figcaption></figure> <div class="mw-heading mw-heading2"><h2 id="Major_scientific_recognition">Major scientific recognition</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ralph_L._Brinster&action=edit&section=8" title="Edit section: Major scientific recognition"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In 2003, Brinster was awarded the Wolf Prize in Medicine and was cited for “development of procedures to manipulate mouse ova and embryos, which has enabled transgenesis and its applications in mice. The first scientist to microinject fertilized eggs (with RNA), Brinster was at the forefront of applying these methods to generate transgenic mice”.<sup id="cite_ref-:1_4-2" class="reference"><a href="#cite_note-:1-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Importantly, the first transgenics of any species were made by direct injection of genes into mouse eggs, which has been the major method to generate transgenic animals since it was described. Moreover, the development of the CRISPR/Cas9 approach has now made direct egg injection the choice for germline modification in almost all circumstances and in all species. In 2006, Brinster received a Canada Gairdner Foundation International Award for pioneering discoveries in germline modification in mammals.<sup id="cite_ref-:2_5-4" class="reference"><a href="#cite_note-:2-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> In part the citation read, “his range of contributions is unmatched in the field”. Most recently, Brinster was awarded the 2010 National Medal of Science, the highest accolade bestowed by the United States government on scientists and engineers, from President Barack Obama for his seminal contributions to germline genetic modification. Since the award was established in 1962, Brinster was the first veterinarian in the United States and the eighth scientist from the University of Pennsylvania to win the National Medal of Science.<sup id="cite_ref-:4_7-2" class="reference"><a href="#cite_note-:4-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:0_23-0" class="reference"><a href="#cite_note-:0-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Academic_career">Academic career</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ralph_L._Brinster&action=edit&section=9" title="Edit section: Academic career"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Brinster has spent his entire academic career at the University of Pennsylvania School of Veterinary Medicine; from 1956 to 1960 as a veterinary student, from 1960 to 1964 as a postdoctoral fellow and PhD Candidate, and then continuing as a faculty member.<sup id="cite_ref-:12_24-0" class="reference"><a href="#cite_note-:12-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> He was appointed associate professor in 1966, professor in 1970, and the Richard King Mellon Professor of Reproductive Physiology in 1975, a position he still holds. In 1969 he founded the Veterinary Medical Scientist Training Program, the first and only combined VMD (DVM)/PhD program funded by the National Institutes of Health, serving as its Director until 1984. Since 1969 the Program has trained more than 100 combined degree graduates that serve in many senior positions throughout the country. From 1997 to 2007, he was Scientific Director of the Center for Animal Transgenesis and Germ Cell Research at the School of Veterinary Medicine. From 2007 to 2008, he was Founding Co-Director of the <a rel="nofollow" class="external text" href="https://irm.med.upenn.edu/">Institute for Regenerative Medicine</a> of the University of Pennsylvania, one of the leading programs in the world. He trained more than 50 pre-doctoral and postdoctoral fellows in his laboratory and taught physiology to professional students in the School of Veterinary Medicine every year from 1964 to 2020. In 2020, the Ralph L. Brinster President’s Distinguished Professorship was established by the University of Pennsylvania to recognize the outstanding scientific contributions of Brinster.<sup id="cite_ref-:13_25-0" class="reference"><a href="#cite_note-:13-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Personal_history">Personal history</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ralph_L._Brinster&action=edit&section=10" title="Edit section: Personal history"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In 1961, Brinster married Elaine Redding, a registered nurse and graduate of the Philadelphia General Hospital School of Nursing, and they currently reside in Gladwyne, PA. They have four children. Lauren R. Brinster earned her VMD from the School of Veterinary Medicine at the University of Pennsylvania. She is a veterinary pathologist at the National Institutes of Health, Bethesda, MD. Kristen A. Brinster earned her Juris Doctor from the <a href="/wiki/University_of_Baltimore_School_of_Law" title="University of Baltimore School of Law">University of Baltimore School of Law</a>. She is a trial lawyer and the founding managing partner of Sutherland & Brinster, PA in Maryland. Derek R. Brinster earned his MD from the <a href="/wiki/Perelman_School_of_Medicine_at_the_University_of_Pennsylvania" class="mw-redirect" title="Perelman School of Medicine at the University of Pennsylvania">Perelman School of Medicine at the University of Pennsylvania</a>. He is a Professor of Cardiovascular and Thoracic Surgery and Director of Aortic Surgery at Northwell Health, New York, NY. Clayton J. Brinster earned an MD from the Perelman School of Medicine at the University of Pennsylvania. He is Director, Center for Aortic Diseases and Associate Professor of Vascular and Endovascular Surgery at the University of Chicago Medical Center in Chicago, IL. In 2021, the Elaine Redding Brinster Prize in Science or Medicine was established by the children to recognize the enormous contribution of Elaine to the achievements of the family. The $200,000 Prize and Medallion are to be awarded annually to an outstanding scientist from any country by the <a rel="nofollow" class="external text" href="https://irm.med.upenn.edu/brinster/">Institute for Regenerative Medicine</a> of the University of Pennsylvania during the Annual Ralph L. Brinster Symposium. </p> <div class="mw-heading mw-heading2"><h2 id="Awards_and_honors">Awards and honors</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ralph_L._Brinster&action=edit&section=11" title="Edit section: Awards and honors"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>1960–1961 American Veterinary Medical Association Fellow University of Pennsylvania, Graduate School of Arts & Sciences</li> <li>1961–1964 Pennsylvania Plan Scholar University of Pennsylvania, Graduate School of Arts & Sciences</li> <li>1983 Award in Biological and Medical Sciences New York Academy of Sciences</li> <li>1984 Harvey Society Lecturer</li> <li>1986 Fellow of the <a href="/wiki/American_Academy_of_Arts_and_Sciences" title="American Academy of Arts and Sciences">American Academy of Arts and Sciences</a><sup id="cite_ref-AAAS_2-1" class="reference"><a href="#cite_note-AAAS-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></li> <li>1986 Member of the <a href="/wiki/Institute_of_Medicine" class="mw-redirect" title="Institute of Medicine">Institute of Medicine</a> National Academy of Sciences</li> <li>1987 Honored by an International Symposium W. Alton Jones Cell Science Center</li> <li>1987 Member of the <a href="/wiki/United_States_National_Academy_of_Sciences" class="mw-redirect" title="United States National Academy of Sciences">National Academy of Sciences</a></li> <li>1989 <a href="/wiki/Fellow_of_the_American_Association_for_the_Advancement_of_Science" title="Fellow of the American Association for the Advancement of Science">Fellow of the American Association for the Advancement of Science</a></li> <li>1989 Distinguished Service Award <a href="/wiki/U.S._Department_of_Agriculture" class="mw-redirect" title="U.S. Department of Agriculture">U.S. Department of Agriculture</a></li> <li>1991 Nobel Symposium Invited Lecturer, Stockholm, Sweden</li> <li>1992 Fellow <a href="/wiki/American_Academy_of_Microbiology" class="mw-redirect" title="American Academy of Microbiology">American Academy of Microbiology</a></li> <li>1992 <a href="/wiki/Fundaci%C3%B3n_Juan_March" title="Fundación Juan March">Fundación Juan March</a> Lecture Madrid, Spain</li> <li>1992 Pioneer Award of the International Embryo Transfer Society</li> <li>1994 <a href="/wiki/Grand_Prix_Charles-Leopold_Mayer" title="Grand Prix Charles-Leopold Mayer">Grand Prix Charles-Leopold Mayer</a> highest honor of the French Academy of Sciences (with Richard Palmiter)</li> <li>1994 Doctor Honoris Causa in Medicine University of the Basque Country, Spain</li> <li>1995 Alumni Award of Merit University of Pennsylvania, School of Veterinary Medicine</li> <li>1996 <a href="/wiki/March_of_Dimes_Prize_in_Developmental_Biology" title="March of Dimes Prize in Developmental Biology">March of Dimes Prize in Developmental Biology</a> with <a href="/wiki/Beatrice_Mintz" title="Beatrice Mintz">Beatrice Mintz</a> (inaugural year)<sup id="cite_ref-:12_24-1" class="reference"><a href="#cite_note-:12-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup></li> <li>1997 <a href="/wiki/The_Franklin_Institute_Awards" class="mw-redirect" title="The Franklin Institute Awards">Bower Award and Prize for Achievement in Science</a> Franklin Institute<sup id="cite_ref-26" class="reference"><a href="#cite_note-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup></li> <li>1997 Carl Hartman Award of the Society for the Study of Reproduction<sup id="cite_ref-:3_6-3" class="reference"><a href="#cite_note-:3-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></li> <li>1997 <a href="/wiki/John_Scott_Medal" title="John Scott Medal">John Scott Medal</a> for Scientific Achievement City Trusts of Philadelphia<sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup></li> <li>1998 Honored by a Special Festschrift Issue, dedicated to Dr. Brinster and the worldwide impact of his contributions; <a href="/wiki/International_Journal_of_Developmental_Biology" class="mw-redirect" title="International Journal of Developmental Biology">International Journal of Developmental Biology</a></li> <li>1998 Pioneer in Reproduction Research Award National Institute of Child Health & Human Development</li> <li>1999 George Hammel Cook Distinguished Alumni Award Rutgers, The State University of New Jersey<sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup></li> <li>2000 Charlton Lecture Tufts University School of Medicine</li> <li>2000 Honorary Doctor of Science Degree from Rutgers, The State University of New Jersey</li> <li>2001 Ernst W. Bertner Award University of Texas M.D. Anderson Cancer Center, in recognition of pioneering contributions to cancer research.</li> <li>2002 Highly Cited Researcher (1980-2000), Designated by the Institute for Scientific Information. About 1 in 1000 authors are in this category.</li> <li>2003 <a href="/wiki/Wolf_Prize_in_Medicine" title="Wolf Prize in Medicine">Wolf Prize in Medicine</a>, Israel "for the development of procedures to manipulate mouse ova and embryos, which has enabled transgenesis and its applications in mice". with <a href="/wiki/Mario_Capecchi" title="Mario Capecchi">Mario Capecchi</a> and <a href="/wiki/Oliver_Smithies" title="Oliver Smithies">Oliver Smithies</a><sup id="cite_ref-:1_4-3" class="reference"><a href="#cite_note-:1-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></li> <li>2003 Selected for the Hall of Honor National Institute of Child Health and Human Development (15 members, total)</li> <li>2006 <a href="/wiki/Gairdner_Foundation_International_Award" class="mw-redirect" title="Gairdner Foundation International Award">Gairdner Foundation International Award</a>, Canada "for pioneering discoveries in germ line modification in mammals."<sup id="cite_ref-:2_5-5" class="reference"><a href="#cite_note-:2-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup></li> <li>2010 <a href="/wiki/National_Medal_of_Science" title="National Medal of Science">National Medal of Science</a>, United States "for fundamental contributions to the development and use of transgenic mice."<sup id="cite_ref-:4_7-3" class="reference"><a href="#cite_note-:4-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup></li> <li>2011 <a href="/wiki/International_Society_for_Transgenic_Technologies" title="International Society for Transgenic Technologies">International Society for Transgenic Technologies</a> Award Lifetime Achievement Award.<sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup></li> <li>2012 Lifetime Achievement Award. From the Alumni of the University of Pennsylvania School of Veterinary Medicine.</li> <li>2012 Career Excellence in Theriogenology Award. From the Theriogenology Foundation on behalf of the American College of Theriogenologists and the Society for Theriogenology.</li> <li>2015 Honorary Doctor of Laws, University of Calgary, Canada.</li> <li>2015 Fellow of the American Physiological Society.</li> <li>2017 Ralph L. Brinster President’s Distinguished Professorship, University of Pennsylvania.<sup id="cite_ref-:13_25-1" class="reference"><a href="#cite_note-:13-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup></li> <li>2019 Frontiers of Germ Cell Research. Brinster Spermatogonial Stem Cell Transplantation 25th Anniversary Symposium, University of Pennsylvania School of Veterinary Medicine.</li></ul> <div class="mw-heading mw-heading2"><h2 id="In_popular_culture">In popular culture</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ralph_L._Brinster&action=edit&section=12" title="Edit section: In popular culture"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The widely acclaimed <a href="/wiki/Zadie_Smith" title="Zadie Smith">Zadie Smith</a> novel "<a href="/wiki/White_Teeth" title="White Teeth">White Teeth</a>" features prominently a genetically modified mouse "Futuremouse", based loosely on the transgenic experiments of Palmiter and Brinster in the 1980s. </p><p>In 2017, Dr. Brinster was depicted in his laboratory by portrait artist <a href="/wiki/Mary_Whyte" title="Mary Whyte">Mary Whyte</a>. Mary Whyte was recently presented the <a href="/wiki/Portrait_Society_of_America" title="Portrait Society of America">Portrait Society of America</a> Gold Medal in honor of "a lifelong dedication to excellence, as well as in recognition of a distinguished body of work that serves to foster and enhance fine art portraiture and figurative works in America."<sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ralph_L._Brinster&action=edit&section=13" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width reflist-columns-2"> <ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation book cs1"><a rel="nofollow" class="external text" href="https://www.nationalmedals.org/laureates/ralph-brinster#"><i>Ralph Brinster</i></a>. National Science & Technology Medals Foundation. 2010<span class="reference-accessdate">. Retrieved <span class="nowrap">February 7,</span> 2019</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Ralph+Brinster&rft.pub=National+Science+%26+Technology+Medals+Foundation&rft.date=2010&rft_id=https%3A%2F%2Fwww.nationalmedals.org%2Flaureates%2Fralph-brinster%23&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARalph+L.+Brinster" class="Z3988"></span></span> </li> <li id="cite_note-AAAS-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-AAAS_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-AAAS_2-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.amacad.org/publications/BookofMembers/ChapterB.pdf">"Book of Members, 1780-2010: Chapter B"</a> <span class="cs1-format">(PDF)</span>. American Academy of Arts and Sciences<span class="reference-accessdate">. Retrieved <span class="nowrap">April 16,</span> 2011</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Book+of+Members%2C+1780-2010%3A+Chapter+B&rft.pub=American+Academy+of+Arts+and+Sciences&rft_id=http%3A%2F%2Fwww.amacad.org%2Fpublications%2FBookofMembers%2FChapterB.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARalph+L.+Brinster" class="Z3988"></span></span> </li> <li id="cite_note-dvm-3"><span class="mw-cite-backlink">^ <a href="#cite_ref-dvm_3-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-dvm_3-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDonna_Loyle2012" class="citation magazine cs1">Donna Loyle (November 1, 2012). <a rel="nofollow" class="external text" href="https://pharmaceuticalintelligence.com/2015/09/08/ralph-brinster-father-of-transgenesis/">"Penn researcher shares insights of 50 years studying mammalian germ line"</a>. <i>DVM Magazine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=DVM+Magazine&rft.atitle=Penn+researcher+shares+insights+of+50+years+studying+mammalian+germ+line&rft.date=2012-11-01&rft.au=Donna+Loyle&rft_id=https%3A%2F%2Fpharmaceuticalintelligence.com%2F2015%2F09%2F08%2Fralph-brinster-father-of-transgenesis%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARalph+L.+Brinster" class="Z3988"></span></span> </li> <li id="cite_note-:1-4"><span class="mw-cite-backlink">^ <a href="#cite_ref-:1_4-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:1_4-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-:1_4-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-:1_4-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><i><a rel="nofollow" class="external text" href="https://wolffund.org.il/2018/12/10/ralph-l-brinster/">"Ralph L. Brinster Winner of Wolf Prize in Medicine - 2003"</a>. Wolf Foundation. Retrieved February 7, 2019.</i></span> </li> <li id="cite_note-:2-5"><span class="mw-cite-backlink">^ <a href="#cite_ref-:2_5-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:2_5-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-:2_5-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-:2_5-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-:2_5-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-:2_5-5"><sup><i><b>f</b></i></sup></a></span> <span class="reference-text"><i><a rel="nofollow" class="external text" href="https://gairdner.org/award_winners/ralph-l-brinster/">"Ralph L. Brinster"</a>. Gairdner Foundation. Retrieved February 7, 2019.</i></span> </li> <li id="cite_note-:3-6"><span class="mw-cite-backlink">^ <a href="#cite_ref-:3_6-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:3_6-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-:3_6-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-:3_6-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><i><a rel="nofollow" class="external text" href="https://higherlogicdownload.s3.amazonaws.com/SSR/fbd87d69-d53f-458a-8220-829febdf990b/UploadedImages/Documents/Past_Award_Recipients/1997_brinster.pdf">"1997 Carl G. Hartman Award Ralph L. Brinster"</a> (PDF). March 15, 2004. Retrieved February 7,2019.</i></span> </li> <li id="cite_note-:4-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-:4_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:4_7-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-:4_7-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-:4_7-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><i><a rel="nofollow" class="external text" href="https://obamawhitehouse.archives.gov/the-press-office/2011/09/27/president-obama-honors-nation-s-top-scientists-and-innovators">"President Obama Honors Nation's Top Scientists and Innovators"</a>. The White House. September 27, 2011. Retrieved February 7, 2019.</i></span> </li> <li id="cite_note-:5-8"><span class="mw-cite-backlink">^ <a href="#cite_ref-:5_8-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:5_8-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text">Arechaga, Juan; <a rel="nofollow" class="external text" href="http://www.ijdb.ehu.es/web/paper.php?doi=9853816">Embryo culture, stem cells and experimental modification of the embryonic genome; An interview with Professor Ralph Brinster</a>; Int. J. Dev. Biol. 42: 861-877 (1998)</span> </li> <li id="cite_note-:7-9"><span class="mw-cite-backlink">^ <a href="#cite_ref-:7_9-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:7_9-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-:7_9-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text">Brinster, R. L. <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881842/">A method for <i>in vitro</i> cultivation of mouse ova from two-cell to blastocyst</a>. Exp Cell Res.1963; 32: 205-208.</span> </li> <li id="cite_note-:6-10"><span class="mw-cite-backlink">^ <a href="#cite_ref-:6_10-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:6_10-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text">Hammer RE. <a rel="nofollow" class="external text" href="http://www.ijdb.ehu.es/web/paper.php?doi=9853812">Egg culture: the foundation.</a> Int J Dev Biol. 1998;42(7):833-9. PMID 9853812.</span> </li> <li id="cite_note-:14-11"><span class="mw-cite-backlink">^ <a href="#cite_ref-:14_11-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:14_11-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text">Brinster, R. L. <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139639/pdf/1049.pdf">The effect of cells transferred into the mouse blastocyst on subsequent development.</a> J. Exp. Med. 1974; 140: 1049-1056.</span> </li> <li id="cite_note-:10-12"><span class="mw-cite-backlink">^ <a href="#cite_ref-:10_12-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:10_12-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text">Palmiter, R. D., Brinster, R. L., Hammer, R. E., Trumbauer, M. E., Rosenfeld, M. G., Birnberg, N. C., and Evans, R. M. <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881848/pdf/nihms-788390.pdf">Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes.</a> Nature. 1982; 300: 611-615.</span> </li> <li id="cite_note-:15-13"><span class="mw-cite-backlink">^ <a href="#cite_ref-:15_13-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:15_13-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text">Brinster, R. L. and Palmiter, R. D. <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889446/">Introduction of genes into the germ line of animals. In: Harvey Lectures Series 80.</a> New York: Alan R. Liss, Inc.; 1986. 1-38.</span> </li> <li id="cite_note-:8-14"><span class="mw-cite-backlink">^ <a href="#cite_ref-:8_14-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:8_14-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text">Brinster, R. L., Chen, H. Y., Trumbauer, M. E., and Avarbock, M. R. <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889339/">Translation of globin messenger RNA by the mouse ovum.</a> Nature. 1980; 283: 499-501.</span> </li> <li id="cite_note-:9-15"><span class="mw-cite-backlink">^ <a href="#cite_ref-:9_15-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:9_15-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text">Brinster, R. L., Chen, H. Y., and Trumbauer, M. E. <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879879/pdf/nihms788373.pdf">Mouse oocytes transcribe injected Xenopus 5S RNA gene.</a> Science. 1981; 211: 396-398.</span> </li> <li id="cite_note-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-16">^</a></b></span> <span class="reference-text">Brinster, R. L., Chen, H. Y., Trumbauer, M. E., Senear, A. W., Warren, R., and Palmiter, R. D. <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883678/pdf/nihms788376.pdf">Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs</a>. Cell. 1981; 27: 223-231.</span> </li> <li id="cite_note-17"><span class="mw-cite-backlink"><b><a href="#cite_ref-17">^</a></b></span> <span class="reference-text">Brinster, R. L., Chen, H. Y., Messing, A., Van Dyke, T., Levine, A. J., and Palmiter, R. D. <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889224/pdf/nihms788400.pdf">Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors.</a> Cell. 1984; 37: 367-379.</span> </li> <li id="cite_note-18"><span class="mw-cite-backlink"><b><a href="#cite_ref-18">^</a></b></span> <span class="reference-text">Brinster, R. L., Braun, R. E., Lo, D., Avarbock, M. A., Oram, F., and Palmiter, R. D. <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC297999/pdf/pnas00285-0266.pdf">Targeted correction of a class II Ea gene by DNA microinjected into mouse eggs</a>. Proc. Natl. Acad. Sci. USA. 1989; 86: 7087-7091.</span> </li> <li id="cite_note-19"><span class="mw-cite-backlink"><b><a href="#cite_ref-19">^</a></b></span> <span class="reference-text"><i>Hammer, Robert E.; Pursel, Vernon G.; Rexroad, Caird E.; Wall, Robert J.; Bolt, Douglas J.; Ebert, Karl M.; Palmiter, Richard D.; Brinster, Ralph L. (1985). <a rel="nofollow" class="external text" href="https://www.nature.com/articles/315680a0">"Production of transgenic rabbits, sheep and pigs by microinjection".</a> Nature. <b>315</b>(6021): 680–683. Bibcode:1985Natur.315..680H. doi:10.1038/315680a0. PMID 3892305. S2CID 4354002.</i></span> </li> <li id="cite_note-:16-20"><span class="mw-cite-backlink">^ <a href="#cite_ref-:16_20-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:16_20-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-:16_20-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text">Kubota, H. and Brinster, R.L. <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692861/pdf/ioy077.pdf">Spermatogonial stem cells.</a> Biol. Reprod. 2018 Mar.; 99(0) 50th Anniversary Special Issue: 1-23. DOI: 10.1093/biolre/ioy077; PMID 29617903</span> </li> <li id="cite_note-:11-21"><span class="mw-cite-backlink">^ <a href="#cite_ref-:11_21-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:11_21-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-:11_21-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text">Brinster, R. L. <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889115/pdf/nihms788706.pdf">Male germline stem cells: From mice to men.</a> Science. 2007 Apr; 316: 404-405</span> </li> <li id="cite_note-22"><span class="mw-cite-backlink"><b><a href="#cite_ref-22">^</a></b></span> <span class="reference-text">Brinster, R. L., and Avarbock, M. R. <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC45219/pdf/pnas01146-0030.pdf">Germline transmission of donor haplotype following spermatogonial transplantation.</a> Proc. Natl. Acad. Sci. USA. 1994; 91: 11303-11307.</span> </li> <li id="cite_note-:0-23"><span class="mw-cite-backlink"><b><a href="#cite_ref-:0_23-0">^</a></b></span> <span class="reference-text"><i><a rel="nofollow" class="external text" href="https://nationalmedals.org/laureate/ralph-brinster/">Ralph Brinster</a>. National Science & Technology Medals Foundation. 2010. Retrieved February 7, 2019.</i></span> </li> <li id="cite_note-:12-24"><span class="mw-cite-backlink">^ <a href="#cite_ref-:12_24-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:12_24-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.marchofdimes.org/materials/prize-in-developmental-biology-award-recipient-history.pdf">"Prize Award Recipient History"</a> <span class="cs1-format">(PDF)</span><span class="reference-accessdate">. Retrieved <span class="nowrap">February 7,</span> 2019</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Prize+Award+Recipient+History&rft_id=https%3A%2F%2Fwww.marchofdimes.org%2Fmaterials%2Fprize-in-developmental-biology-award-recipient-history.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARalph+L.+Brinster" class="Z3988"></span></span> </li> <li id="cite_note-:13-25"><span class="mw-cite-backlink">^ <a href="#cite_ref-:13_25-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:13_25-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation magazine cs1"><a rel="nofollow" class="external text" href="https://almanac.upenn.edu/articles/3-million-gift-to-establish-the-ralph-l-brinster-presidents-distinguished-professorship-in-honor">"$3 Million Gift to Establish the Ralph L. Brinster President's Distinguished Professorship in Honor"</a>. <i>University of Pennsylvania Almanac</i>. Vol. 63, no. 30. April 11, 2017.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=University+of+Pennsylvania+Almanac&rft.atitle=%243+Million+Gift+to+Establish+the+Ralph+L.+Brinster+President%27s+Distinguished+Professorship+in+Honor&rft.volume=63&rft.issue=30&rft.date=2017-04-11&rft_id=https%3A%2F%2Falmanac.upenn.edu%2Farticles%2F3-million-gift-to-establish-the-ralph-l-brinster-presidents-distinguished-professorship-in-honor&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARalph+L.+Brinster" class="Z3988"></span></span> </li> <li id="cite_note-26"><span class="mw-cite-backlink"><b><a href="#cite_ref-26">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.fi.edu/laureates/ralph-l-brinster">"Ralph L. Brinster | 1997 Bower Award and Prize for Achievement in Science"</a>. January 15, 2014<span class="reference-accessdate">. Retrieved <span class="nowrap">February 7,</span> 2019</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Ralph+L.+Brinster+%26%23124%3B+1997+Bower+Award+and+Prize+for+Achievement+in+Science&rft.date=2014-01-15&rft_id=https%3A%2F%2Fwww.fi.edu%2Flaureates%2Fralph-l-brinster&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARalph+L.+Brinster" class="Z3988"></span></span> </li> <li id="cite_note-27"><span class="mw-cite-backlink"><b><a href="#cite_ref-27">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.garfield.library.upenn.edu/johnscottaward/johnscottaward%28full%29.html">"The John Scott Award"</a><span class="reference-accessdate">. Retrieved <span class="nowrap">February 7,</span> 2019</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=The+John+Scott+Award&rft_id=http%3A%2F%2Fwww.garfield.library.upenn.edu%2Fjohnscottaward%2Fjohnscottaward%2528full%2529.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARalph+L.+Brinster" class="Z3988"></span></span> </li> <li id="cite_note-28"><span class="mw-cite-backlink"><b><a href="#cite_ref-28">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation news cs1"><a rel="nofollow" class="external text" href="https://sebsnjaesnews.rutgers.edu/2014/02/alumni-profile-ralph-brinster-ag-53-veterinarian-and-human-health-revolutionary/">"Alumni Story: Ralph Brinster (AG '53): Veterinarian and Human Health Revolutionary"</a>. Rutgers University. February 24, 2014<span class="reference-accessdate">. Retrieved <span class="nowrap">February 7,</span> 2019</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Alumni+Story%3A+Ralph+Brinster+%28AG+%2753%29%3A+Veterinarian+and+Human+Health+Revolutionary&rft.date=2014-02-24&rft_id=https%3A%2F%2Fsebsnjaesnews.rutgers.edu%2F2014%2F02%2Falumni-profile-ralph-brinster-ag-53-veterinarian-and-human-health-revolutionary%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARalph+L.+Brinster" class="Z3988"></span></span> </li> <li id="cite_note-29"><span class="mw-cite-backlink"><b><a href="#cite_ref-29">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation journal cs1"><a rel="nofollow" class="external text" href="http://link.springer.com/10.1007/s11248-011-9540-8">"Program and Abstracts of the 10th Transgenic Technology Meeting (TT2011): TradeWinds Island Grand Resort, St Pete Beach, Florida, USA, October 24–26, 2011"</a>. <i>Transgenic Research</i>. <b>20</b> (5): <span class="nowrap">1139–</span>1189. October 1, 2011. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs11248-011-9540-8">10.1007/s11248-011-9540-8</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0962-8819">0962-8819</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Transgenic+Research&rft.atitle=Program+and+Abstracts+of+the+10th+Transgenic+Technology+Meeting+%28TT2011%29%3A+TradeWinds+Island+Grand+Resort%2C+St+Pete+Beach%2C+Florida%2C+USA%2C+October+24%E2%80%9326%2C+2011&rft.volume=20&rft.issue=5&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1139-%3C%2Fspan%3E1189&rft.date=2011-10-01&rft_id=info%3Adoi%2F10.1007%2Fs11248-011-9540-8&rft.issn=0962-8819&rft_id=http%3A%2F%2Flink.springer.com%2F10.1007%2Fs11248-011-9540-8&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARalph+L.+Brinster" class="Z3988"></span></span> </li> <li id="cite_note-30"><span class="mw-cite-backlink"><b><a href="#cite_ref-30">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation news cs1"><a rel="nofollow" class="external text" href="http://www.postandcourier.com/features/arts_and_travel/local-arts-in-brief/article_6ff8f7b0-d1f9-576a-af6b-af9bc1b8be71.html">"Arts in Brief"</a>. <i>The Post and Courier</i>. May 7, 2016<span class="reference-accessdate">. Retrieved <span class="nowrap">March 26,</span> 2017</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Post+and+Courier&rft.atitle=Arts+in+Brief&rft.date=2016-05-07&rft_id=http%3A%2F%2Fwww.postandcourier.com%2Ffeatures%2Farts_and_travel%2Flocal-arts-in-brief%2Farticle_6ff8f7b0-d1f9-576a-af6b-af9bc1b8be71.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARalph+L.+Brinster" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ralph_L._Brinster&action=edit&section=14" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>Link to Website: <a rel="nofollow" class="external free" href="http://www.vet.upenn.edu/research/research-laboratories/research-laboratory/brinster-laboratory-of-reproductive-physiology">http://www.vet.upenn.edu/research/research-laboratories/research-laboratory/brinster-laboratory-of-reproductive-physiology</a></li> <li>Link to Brinster National Medal of Science Lecture: <a rel="nofollow" class="external free" href="https://www.youtube.com/watch?v=nLmVlFRBUZ8">https://www.youtube.com/watch?v=nLmVlFRBUZ8</a></li> <li>Link to Brinster National Medal of Science Award Ceremony: <a rel="nofollow" class="external free" href="https://www.youtube.com/watch?v=mOuBjuUQyJI">https://www.youtube.com/watch?v=mOuBjuUQyJI</a></li> <li>Link to NICHD Colloquium December 2012, Lecture #5: <a rel="nofollow" class="external free" href="http://videocast.nih.gov/summary.asp?Live=12182&bhcp=1">http://videocast.nih.gov/summary.asp?Live=12182&bhcp=1</a>; Research Summary 20 min.</li> <li>Link to NICHD Hall of Honor Induction 2003 Lecture at 1 hr 5 min.: <a rel="nofollow" class="external text" href="https://videocast.nih.gov/watch=8757?jwsource=cl">NIH VideoCast - NICHD 40th Anniversary Hall of Honor Induction</a>; Autobiography 20 min.</li> <li><a rel="nofollow" class="external text" href="https://wolffund.org.il/2018/12/10/ralph-l-brinster/">The Wolf Prize in Medicine in 2002/3 (detail)</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul 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aria-labelledby="Laureates_of_the_Wolf_Prize_in_Medicine73" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#d3d3d3;"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Wolf_Prize_in_Medicine" title="Template:Wolf Prize in Medicine"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Wolf_Prize_in_Medicine" title="Template talk:Wolf Prize in Medicine"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Wolf_Prize_in_Medicine" title="Special:EditPage/Template:Wolf Prize in Medicine"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Laureates_of_the_Wolf_Prize_in_Medicine73" style="font-size:114%;margin:0 4em">Laureates of the <a href="/wiki/Wolf_Prize_in_Medicine" title="Wolf Prize in Medicine">Wolf Prize in Medicine</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#d3d3d3;">1970s</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/George_Davis_Snell" title="George Davis Snell">George Snell</a> / <a href="/wiki/Jean_Dausset" title="Jean Dausset">Jean Dausset</a> / <a href="/wiki/Jon_van_Rood" title="Jon van Rood">Jon J. van Rood</a> (1978)</li> <li><a href="/wiki/Roger_Wolcott_Sperry" title="Roger Wolcott Sperry">Roger Sperry</a> / <a href="/wiki/Arvid_Carlsson" title="Arvid Carlsson">Arvid Carlsson</a> / <a href="/wiki/Oleh_Hornykiewicz" title="Oleh Hornykiewicz">Oleh Hornykiewicz</a> (1979)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#d3d3d3;">1980s</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/C%C3%A9sar_Milstein" title="César Milstein">César Milstein</a> / <a href="/wiki/Leo_Sachs" title="Leo Sachs">Leo Sachs</a> / <a href="/wiki/James_Learmonth_Gowans" title="James Learmonth Gowans">James L. Gowans</a> (1980)</li> <li><a href="/wiki/Barbara_McClintock" title="Barbara McClintock">Barbara McClintock</a> / <a href="/wiki/Stanley_Norman_Cohen" title="Stanley Norman Cohen">Stanley Norman Cohen</a> (1981)</li> <li><a href="/wiki/Jean-Pierre_Changeux" title="Jean-Pierre Changeux">Jean-Pierre Changeux</a> / <a href="/wiki/Solomon_H._Snyder" title="Solomon H. Snyder">Solomon H. Snyder</a> / <a href="/wiki/James_Black_(pharmacologist)" title="James Black (pharmacologist)">James W. Black</a> (1982)</li> <li><a href="/wiki/Donald_F._Steiner" title="Donald F. Steiner">Donald F. Steiner</a> (1984/5)</li> <li><a href="/wiki/Osamu_Hayaishi" title="Osamu Hayaishi">Osamu Hayaishi</a> (1986)</li> <li><a href="/wiki/Pedro_Cuatrecasas" title="Pedro Cuatrecasas">Pedro Cuatrecasas</a> / <a href="/wiki/Meir_Wilchek" title="Meir Wilchek">Meir Wilchek</a> (1987)</li> <li><a href="/wiki/Henri_G._Hers" title="Henri G. Hers">Henri G. Hers</a> / <a href="/wiki/Elizabeth_F._Neufeld" title="Elizabeth F. Neufeld">Elizabeth F. Neufeld</a> (1988)</li> <li><a href="/wiki/John_Gurdon" title="John Gurdon">John Gurdon</a> / <a href="/wiki/Edward_B._Lewis" title="Edward B. Lewis">Edward B. Lewis</a> (1989)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#d3d3d3;">1990s</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Maclyn_McCarty" title="Maclyn McCarty">Maclyn McCarty</a> (1990)</li> <li><a href="/wiki/Seymour_Benzer" title="Seymour Benzer">Seymour Benzer</a> (1991)</li> <li><a href="/wiki/Judah_Folkman" title="Judah Folkman">Judah Folkman</a> (1992)</li> <li><a href="/wiki/Michael_Berridge" title="Michael Berridge">Michael Berridge</a> / <a href="/wiki/Yasutomi_Nishizuka" title="Yasutomi Nishizuka">Yasutomi Nishizuka</a> (1994/5)</li> <li><a href="/wiki/Stanley_B._Prusiner" title="Stanley B. Prusiner">Stanley B. Prusiner</a> (1995/6)</li> <li><a href="/wiki/Mary_F._Lyon" title="Mary F. Lyon">Mary F. Lyon</a> (1996/7)</li> <li><a href="/wiki/Michael_Sela" title="Michael Sela">Michael Sela</a> / <a href="/wiki/Ruth_Arnon" title="Ruth Arnon">Ruth Arnon</a> (1998)</li> <li><a href="/wiki/Eric_Kandel" title="Eric Kandel">Eric Kandel</a> (1999)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#d3d3d3;">2000s</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Avram_Hershko" title="Avram Hershko">Avram Hershko</a> / <a href="/wiki/Alexander_Varshavsky" title="Alexander Varshavsky">Alexander Varshavsky</a> (2001)</li> <li><a class="mw-selflink selflink">Ralph L. Brinster</a> / <a href="/wiki/Mario_Capecchi" title="Mario Capecchi">Mario Capecchi</a> / <a href="/wiki/Oliver_Smithies" title="Oliver Smithies">Oliver Smithies</a> (2002/3)</li> <li><a href="/wiki/Robert_Weinberg_(biologist)" title="Robert Weinberg (biologist)">Robert Weinberg</a> / <a href="/wiki/Roger_Y._Tsien" title="Roger Y. Tsien">Roger Y. Tsien</a> (2004)</li> <li><a href="/wiki/Alexander_Levitzki" title="Alexander Levitzki">Alexander Levitzki</a> / <a href="/wiki/Anthony_R._Hunter" title="Anthony R. Hunter">Anthony R. Hunter</a> / <a href="/wiki/Tony_Pawson_(biochemist)" title="Tony Pawson (biochemist)">Tony Pawson</a> (2005)</li> <li><a href="/wiki/Howard_Cedar" title="Howard Cedar">Howard Cedar</a> / <a href="/wiki/Aharon_Razin" title="Aharon Razin">Aharon Razin</a> (2008)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#d3d3d3;">2010s</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Axel_Ullrich" title="Axel Ullrich">Axel Ullrich</a> (2010)</li> <li><a href="/wiki/Shinya_Yamanaka" title="Shinya Yamanaka">Shinya Yamanaka</a> / <a href="/wiki/Rudolf_Jaenisch" title="Rudolf Jaenisch">Rudolf Jaenisch</a> (2011)</li> <li><a href="/wiki/Ronald_M._Evans" title="Ronald M. Evans">Ronald M. Evans</a> (2012)</li> <li><a href="/wiki/Nahum_Sonenberg" title="Nahum Sonenberg">Nahum Sonenberg</a> / <a href="/wiki/Gary_Ruvkun" title="Gary Ruvkun">Gary Ruvkun</a> / <a href="/wiki/Victor_Ambros" title="Victor Ambros">Victor Ambros</a> (2014)</li> <li><a href="/wiki/John_Kappler" title="John Kappler">John Kappler</a> / <a href="/wiki/Philippa_Marrack" title="Philippa Marrack">Philippa Marrack</a> / <a href="/wiki/Jeffrey_V._Ravetch" title="Jeffrey V. Ravetch">Jeffrey V. Ravetch</a> (2015)</li> <li><a href="/wiki/Lewis_C._Cantley" title="Lewis C. Cantley">Lewis C. Cantley</a> / <a href="/wiki/C._Ronald_Kahn" title="C. Ronald Kahn">C. Ronald Kahn</a> (2016)</li> <li><a href="/wiki/James_P._Allison" title="James P. Allison">James P. Allison</a> (2017)</li> <li><a href="/wiki/Jeffrey_M._Friedman" title="Jeffrey M. Friedman">Jeffrey M. Friedman</a> (2019)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#d3d3d3;">2020s</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Emmanuelle_Charpentier" title="Emmanuelle Charpentier">Emmanuelle Charpentier</a> / <a href="/wiki/Jennifer_Doudna" title="Jennifer Doudna">Jennifer Doudna</a> (2020)</li> <li><a href="/wiki/Joan_Steitz" class="mw-redirect" title="Joan Steitz">Joan Steitz</a> / <a href="/wiki/Lynne_Maquat" class="mw-redirect" title="Lynne Maquat">Lynne Elizabeth Maquat</a> / <a href="/wiki/Adrian_R._Krainer" class="mw-redirect" title="Adrian R. Krainer">Adrian Krainer</a> (2021)</li> <li><a href="/wiki/Daniel_J._Drucker" title="Daniel J. Drucker">Daniel J. Drucker</a> (2023)</li> <li><a href="/wiki/Botond_Roska" title="Botond Roska">Botond Roska</a> / <a href="/wiki/Jos%C3%A9-Alain_Sahel" title="José-Alain Sahel">José-Alain Sahel</a> (2024)</li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=0" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Ralph_L._Brinster&oldid=1242360164">https://en.wikipedia.org/w/index.php?title=Ralph_L._Brinster&oldid=1242360164</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:1932_births" title="Category:1932 births">1932 births</a></li><li><a href="/wiki/Category:American_geneticists" title="Category:American geneticists">American geneticists</a></li><li><a href="/wiki/Category:United_States_Air_Force_personnel_of_the_Korean_War" title="Category:United States Air Force personnel of the Korean War">United States Air Force personnel of the Korean War</a></li><li><a href="/wiki/Category:Fellows_of_the_American_Academy_of_Arts_and_Sciences" title="Category:Fellows of the American Academy of Arts and Sciences">Fellows of the American Academy of Arts and Sciences</a></li><li><a href="/wiki/Category:Living_people" title="Category:Living people">Living people</a></li><li><a href="/wiki/Category:Members_of_the_United_States_National_Academy_of_Sciences" title="Category:Members of the United States National Academy of Sciences">Members of the United States National Academy of Sciences</a></li><li><a href="/wiki/Category:People_from_Cedar_Grove,_New_Jersey" title="Category:People from Cedar Grove, New Jersey">People from Cedar Grove, New Jersey</a></li><li><a href="/wiki/Category:Rutgers_University_alumni" title="Category:Rutgers University alumni">Rutgers University alumni</a></li><li><a href="/wiki/Category:United_States_Air_Force_officers" title="Category:United States Air Force officers">United States Air Force officers</a></li><li><a href="/wiki/Category:University_of_Pennsylvania_School_of_Veterinary_Medicine_alumni" title="Category:University of Pennsylvania School of Veterinary Medicine alumni">University of Pennsylvania School of Veterinary Medicine alumni</a></li><li><a href="/wiki/Category:University_of_Pennsylvania_faculty" title="Category:University of Pennsylvania faculty">University of Pennsylvania faculty</a></li><li><a href="/wiki/Category:Wolf_Prize_in_Medicine_laureates" title="Category:Wolf Prize in Medicine laureates">Wolf Prize in Medicine laureates</a></li><li><a href="/wiki/Category:Military_personnel_from_New_Jersey" title="Category:Military personnel from New Jersey">Military personnel from New Jersey</a></li><li><a href="/wiki/Category:Members_of_the_National_Academy_of_Medicine" title="Category:Members of the National Academy of Medicine">Members of the National Academy of Medicine</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Hidden categories: <ul><li><a href="/wiki/Category:Articles_with_short_description" title="Category:Articles with short description">Articles with short description</a></li><li><a href="/wiki/Category:Short_description_matches_Wikidata" title="Category:Short description matches Wikidata">Short description matches Wikidata</a></li><li><a href="/wiki/Category:Use_mdy_dates_from_February_2022" title="Category:Use mdy dates from February 2022">Use mdy dates from February 2022</a></li><li><a href="/wiki/Category:Articles_with_hCards" title="Category:Articles with hCards">Articles with hCards</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> This page was last edited on 26 August 2024, at 13:11<span class="anonymous-show"> (UTC)</span>.</li> <li id="footer-info-copyright">Text is available under the <a href="/wiki/Wikipedia:Text_of_the_Creative_Commons_Attribution-ShareAlike_4.0_International_License" title="Wikipedia:Text of the Creative Commons Attribution-ShareAlike 4.0 International License">Creative Commons Attribution-ShareAlike 4.0 License</a>; additional terms may apply. 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