CINXE.COM

<!DOCTYPE html> <html lang="en"> <head>  <meta http-equiv="X-UA-Compatible" content="IE=edge" /> <meta name="format-detection" content="telephone=no" /> <meta name="viewport" content="width=device-width, initial-scale=1.0, maximum-scale=1.0, user-scalable=0" /> <script> function callIfOrWhenWindowLoaded(func) { if (func != undefined) { if (document.readyState == 'complete' && typeof ($m) !== 'undefined') { func(); } else { if (window.attachEvent) { window.attachEvent('onload', func); } else if (window.addEventListener) { window.addEventListener('load', func, false); } else { document.addEventListener('load', func, false); } } } } </script> <script type="text/javascript"> if (!window.console) console = {log: function() {}, info: function() {}}; </script>  <title> Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8) (MN1020) </title> <link rel="preload stylesheet" type="text/css" as="style" href="/order/genome-database/assets/js/angular/dist/gsh/gsh-header-v2.css?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"/> <link rel="preload stylesheet" type="text/css" as="style" href="/order/genome-database/assets/css/font-common.css?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"/> <link rel="canonical" href="https://www.thermofisher.com/antibody/product/Phospho-Tau-Ser202-Thr205-Antibody-clone-AT8-Monoclonal/MN1020"/> <link rel="alternate" href="https://www.thermofisher.com/antibody/product/Phospho-Tau-Ser202-Thr205-Antibody-clone-AT8-Monoclonal/MN1020" hreflang="en-us"/> <link rel="alternate" href="https://www.thermofisher.cn/cn/zh/antibody/product/Phospho-Tau-Ser202-Thr205-Antibody-clone-AT8-Monoclonal/MN1020" hreflang="zh-cn"/> <link rel="alternate" href="https://www.thermofisher.cn/cn/en/antibody/product/Phospho-Tau-Ser202-Thr205-Antibody-clone-AT8-Monoclonal/MN1020" hreflang="en-cn"/> <link rel="alternate" href="https://www.thermofisher.com/antibody/product/Phospho-Tau-Ser202-Thr205-Antibody-clone-AT8-Monoclonal/MN1020" hreflang="x-default"/>          <meta name="description" content="Invitrogen Anti-Phospho-Tau (Ser202, Thr205) Monoclonal (AT8), Catalog # MN1020. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF) and Immunohistochemistry (Paraffin) (IHC (P)) applications. This antibody reacts with Human, Mouse samples. Supplied as 100 µg purified antibody (0.2 mg/mL)." /> <link rel="dns-prefetch" href="//tools.thermofisher.com" /> <link rel="dns-prefetch" href="//downloads.thermofisher.com" /> <link rel="dns-prefetch" href="//assets.thermofisher.com" /> <link rel="preconnect" href="//assets.adobedtm.com" /> <link rel="dns-prefetch" href="//assets.adobedtm.com" />  <meta charset="utf-8" /> <meta http-equiv="X-UA-Compatible" content="IE=edge" /> <meta name="author" content="" /> <meta http-equiv="cache-control" content="no-cache, must-revalidate" /> <meta http-equiv="expires" content="0" /> <meta http-equiv="pragma" content="no-cache" />  <link rel="preload" as="script" href="/etc/designs/lifetech/clientlibs/base-jquery.min.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"/> <link rel="preload" as="script" href="/etc/designs/lifetech/clientlibs/base-bootstrap.min.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"/> <link rel="preload" as="script" href="/shared-static/scripts/global-variables.js"> <link rel="preload" as="script" href="/shared-static/scripts/global-functions.js">    </head> <body> <script> if (typeof $m === 'undefined' || !$m) { var $m = {}; } $m.basepath = "//" + window.location.host + "/order/genome-database/"; $m.pageName = 'PDP'; $m.curSym = ''; $m.currencyDisplay = ''; $m.lt_rev='VLocal', // Used to defeat caching $m.domainName = 'LT'; $m.portalBaseURL = 'https://www.thermofisher.com/'; $m.keywordTypeaheadBaseURL = 'https://magellan.tfcom-eks-na-magellanprod.magellanprod.thermofisher.net/solr/lt-magellan-search-core/select'; $m.inventoryLocationCountryLists = 'UK-AT-BE-BG-HR-CZ-DK-EE-FI-FR-DE-GB-GR-HU-IS-IE-IL-IT-LT-LU-MT-NL-NO-PL-PT-RO-SK-ES-SE-CH-TR'; $m.isLeadTimeEnabled = false; $m.mapDataServer = 'https://www.thermofisher.com/api/magellan/alignmap/map-server'; $m.CID = ''; $m.ICID = ''; $m.isLoggedIn = false; $m.pluginURLParm = ''; $m.isoLanguage = 'en'; $m.translationEnabledProducts = 'antibody;immunoassay'; $m.buildNumber = 'Local'; $m.buildTimestamp = '2024-11-22T02:34:20+0000'; //TO-DO Update this whenever there is change in strategy for Apple $m.apple = '-apple'; $m.useFisherSciMfgPart = 'false'; $m.useAdobeLaunch = 'true'; </script> <header class="header"> <div class="globalHeader" id="hfGlobalHeader" data-orig="tfpt-header-footer" data-app-env="prod" data-site="tf" data-hostname="www.thermofisher.com" data-x-host="www.thermofisher.com" data-env="prod" data-hash="468bd07150dbbf" data-version="4.03.29" data-analytics-section="header" data-aem-syndication-info="(sg:en-sg:anonymous:https-tf)" data-aem-syndication-timestamp="globalHeader: Wed, 27 Nov 2024 12:49:08 GMT" data-optional-selectors="inlineCss,globalRoute">          <script type="text/javascript"> // define the console object if it is not available as a temporary fix for console.log issues on IE 8 if(!(window.console && console.log)) { console = { log: function(){}, debug: function(){}, info: function(){}, warn: function(){}, error: function(){} }; } </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("globalHeader:renderBegin"); </script>  <script data-inline-file-name='trust-arc.min.js' data-inline-site='tf'>/* Hash: 468bd07150dbbf Source: /tf/js/dist/trust-arc.min.js */ window.hfSite="tf",window.trustArc={consentInsights:{api_key:"",secret:""},init:function(e,t,n,r){if(window.trustArc.countryCode=e,window.trustArc.languageCode=t,window.trustArc.ut=window.trustArc.preferences()?"RETURNING":"NEW",window.trustArc.privacyURL=document.location.origin+"/"+e+"/"+t+"/home/global/privacy-policy.html",window.trustArc.cookieURL=document.location.origin+"/"+e+"/"+t+"/home/global/how-cookies-are-used.html","uk"===e&&(e="gb"),"ic"===e&&(e="es"),"br"===e&&"pt"===t&&(t="pt_br"),"zh"===t&&(t="zh_hans"),"zt"===t&&(t="zh_cn"),window.trustArc.CMurl="//consent.truste.com/notice?c=teconsent&pcookie=true&js=nj&gtm=true&noticeType=bb&text=true&domain="+n+"&country="+e+"&language="+t+"&privacypolicylink=",window.trustArc.tagManagerURL=r,window.trustArc.injectCM(),r.indexOf("development")>-1||r.indexOf("staging")>-1?(window.trustArc.consentInsights.api_key="CI-7153680989",window.trustArc.consentInsights.secret="791102116598381495740862696243996077676903892648153044076559127326113493625826883438963034185582914868990705664"):(window.trustArc.consentInsights.api_key="CI-3929813243",window.trustArc.consentInsights.secret="810274278902470721624405905887912991104270295366493143855663183685375235160482241511078341257235422202822656000"),!window.sessionStorage.ciVisitId&&!window.localStorage.consentInsightsVisitRecorded){var s=URL.createObjectURL(new Blob);window.sessionStorage.ciVisitId=s.substring(s.lastIndexOf("/")+1),window.trustArc.sendMetric("visit")}document.body.addEventListener("truste-consent",function(){var e=getCookie("notice_gdpr_prefs");if(window.localStorage.consentInsightsConsentRecorded||window.trustArc.sendMetric("consent"),window.trustArc.tagManagerURL&&!document.querySelector("#tagmanager")&&(e.includes("1")||e.includes("2"))){var t=document.createElement("script");t.id="tagmanager",t.src=window.trustArc.tagManagerURL,t.type="text/javascript",document.head.appendChild(t)}}),setTimeout(function(){var e=document.querySelector("#truste-consent-track");e&&"block"===e.style.display&&window.trustArc.sendMetric("impression")},1e3),window.addEventListener("message",function(e){try{"cm_loading"!==JSON.parse(e.data).message||window.localStorage.consentInsightsImpressionRecorded||window.trustArc.sendMetric("impression")}catch(e){"SyntaxError"!=e.name&&console.log(e)}},!1)},injectCM:function(){var e=document.createElement("script");e.async=!0,e.src=window.trustArc.CMurl+window.trustArc.privacyURL+"&cookieLink="+window.trustArc.cookieURL,e.setAttribute("crossorigin",!0),document.head.appendChild(e)},preferences:function(){return getCookie("notice_gdpr_prefs")},requiredReady:function(){return!0},functionalReady:function(){return window.trustArc.preferences().includes("1")},advertisementReady:function(){return window.trustArc.preferences().includes("2")},enable:function(e){return e||!e&&window.location.href.includes("eta=true")},sendMetric:function(e){var t=new URL("https://consent-insights-3c23a978f31a.herokuapp.com/api/v1/visits/capture"),n=new URL("https://consent-insights-3c23a978f31a.herokuapp.com/api/v1/impressions/capture"),r=new URL("https://consent-insights-3c23a978f31a.herokuapp.com/api/v1/consents/capture"),s="";switch(e){case"visit":s=t;break;case"impression":s=n;break;case"consent":s=r}s.searchParams.append("api_key",window.trustArc.consentInsights.api_key),s.searchParams.append("secret",window.trustArc.consentInsights.secret),s.searchParams.append("country",window.trustArc.countryCode),s.searchParams.append("language",window.trustArc.languageCode),s.searchParams.append("visit_id",window.sessionStorage.ciVisitId),s.searchParams.append("ut",window.trustArc.ut),window.trustArc.preferences()&&s.searchParams.append("preferences",window.trustArc.preferences()),s.searchParams.append("ua",navigator.userAgent),s.searchParams.append("title",document.title),s.searchParams.append("url",window.location.href);var i=document.createElement("img");i.src=s,i.alt="1x1 image pixel for data collection",document.body.appendChild(i),"visit"===e&&(window.localStorage.consentInsightsVisitRecorded=!0),"impression"===e&&(window.localStorage.consentInsightsImpressionRecorded=!0),"consent"===e&&(window.localStorage.consentInsightsConsentRecorded=!0)}};</script> <script type="text/javascript"> document.addEventListener("DOMContentLoaded", function(){ if (window.trustArc.enable(true) && !(/how-cookies-are-used|privacy-policy/i.test(window.location.href))) { window.trustArc.init("sg", "en", "thermofisher.com", "https://assets.adobedtm.com/launch-ENeecb77f1160a4928a492ff040f7110c7.min.js"); } }) </script> <script id="inlineHFJavascriptConfig" type="text/javascript"> if ( !window.globalHeaderConfig ) { var globalHeaderConfig = {}; } globalHeaderConfig.logoImagePath = '/content/dam/LifeTech/Images/Header/logo-color.png' globalHeaderConfig.scmsEuLogoLinkHref = 'https://commerce.thermofisher.com/customersite/schome.cfm'; globalHeaderConfig.scmsEuLogoImageIe6Path = '/content/dam/LifeTech/Images/Header/supply-centre.png'; globalHeaderConfig.scmsEuLogoImagePath = '/content/dam/LifeTech/Images/Header/supply-center.png'; globalHeaderConfig.scmsEuLogoImagePrintPath = '/content/dam/LifeTech/Images/Header/supply-centre.png'; globalHeaderConfig.scmsShipToLabLogoLinkHref = 'https://commerce.thermofisher.com/customersite/schome.cfm'; globalHeaderConfig.scmsShipToLabLogoImageIe6Path = '/content/dam/LifeTech/Images/Header/logo-color.png'; globalHeaderConfig.scmsShipToLabLogoImagePath = '/content/dam/LifeTech/Images/Header/logo-color.png'; globalHeaderConfig.scmsShipToLabLogoImagePrintPath = '/content/dam/LifeTech/Images/Header/logo-black.png'; globalHeaderConfig.scmsEuShipToLabLogoLinkHref = 'https://commerce.thermofisher.com/customersite/schome.cfm'; globalHeaderConfig.scmsEuShipToLabLogoImageIe6Path = '/content/dam/LifeTech/Images/Header/logo-color.png'; globalHeaderConfig.scmsEuShipToLabLogoImagePath = '/content/dam/LifeTech/Images/Header/logo-color.png'; globalHeaderConfig.scmsEuShipToLabLogoImagePrintPath = '/content/dam/LifeTech/Images/Header/logo-black.png'; globalHeaderConfig.scmsNavLinkTextForEU = 'Supply Centre Settings'; globalHeaderConfig.scmsNavUnlockLinkTextForEU = ''; globalHeaderConfig.scmsNavChangeLocationLinkTextForEU = 'Change My Location'; globalHeaderConfig.scmsNavSetStartPageLinkTextForEU = 'Set My Start Page'; globalHeaderConfig.scmsNavSupplyCenterHomeLinkTextForEU = 'Supply Centre Home'; globalHeaderConfig.scmsNavSupplyCenterHomeForLabLinkTextForEU = 'Supply Centre Home'; globalHeaderConfig.utilityBarSignInForwardLinkHref = '/auth/initiate'; </script> <script data-inline-file-name="https://www.thermofisher.com/dm-offers/preload.min.js"> if(!window.preloadOffers){window.preloadOffers={version:"2024.4.0"};function preLoadOffer(e,t,r,o,f){var n=document.querySelector("#"+e+" , ."+e),d,l;if(!n){if(r<25){r++;setTimeout((function(){preLoadOffer(e,t,r,o,f)}),t);return}return}if(o&&preloadVerifyHtmlOffer(o)){try{n.innerHTML=o;l=n.querySelectorAll("script");for(d=0;d<l.length;d++){preloadOffers.scriptNode.push(l[d])}n.setAttribute("preloaded","true");n.setAttribute("offerUrl",f);dispatchPreloadOffersEvent("requestPostEvents")}catch(e){console.error("could not execute script : "+e)}if(!!f&&f.length>1){try{n.querySelector("a").href=f;console.log("in preload added offerUrl",f,"to",e)}catch(t){console.warn("in preload failed to add offerUrl",f,"to",e)}}}else{showDefaultOfferContent(n);n.setAttribute("preloaded-default","true")}}function preloadVerifyHtmlOffer(e){var t=false,r,o;if(typeof e!=="undefined"&&e.length>0){if(e.indexOf("<head")===-1){t=true}else{r=(new DOMParser).parseFromString(e,"text/html");o=r.querySelector("head");if(o.childElementCount===0){t=true}}}return t}function showDefaultOfferContent(e){try{e.setAttribute("preloaded","false");var t=e.querySelector(" .loading-wheel-block"),r=e.querySelector(" .loading-wheel-block .loading-wheel"),o=e.querySelector(" .loading-wheel-block .defaultOffer");t.style.padding="0px";r.remove();o.removeAttribute("style")}catch(t){console.log("Preload offers - no default offer for div :: "+e.getAttribute("id"))}}function processOfferResp(e){if(e){var t=JSON.parse(e),r,o,f;window.preloadOffers.response=t;window.preloadOffers.scriptNode=[];if(t&&t.hasOwnProperty("offerPlacementMap")){r=t["offerPlacementMap"];for(o in r){f=r[o];preLoadOffer(o,100,1,f.offerHTML,f.offerUrl)}}}}function dispatchPreloadOffersEvent(e){if(document.createEvent){var t=document.createEvent("Event");t.initEvent(e,true,true);document.dispatchEvent(t)}else if(document.createEventObject){if(!!document.documentElement[e]){document.documentElement[e]=1}document.documentElement[e]++}}function getCookie(e){var t=e+"=",r=document.cookie,o=r.indexOf(t),f=null,n;if(o!==-1){n=r.indexOf("; ",o);if(n===-1){n=r.length}f=r.slice(o+t.length,n);f=unescape(f)}return f}if(getCookie("cq-authoring-mode")===null){var preloadUrl="/event/offer/preload",xhttp=new XMLHttpRequest;xhttp.onreadystatechange=function(){if(this.readyState===4){if(!window.preloadOffers){window.preloadOffers={}}if(this.status===200){window.preloadOffers.succeed=true;processOfferResp(this.responseText)}else{window.preloadOffers.succeed=false}dispatchPreloadOffersEvent("preloadOffers");window.preloadOffers.status=this.status;window.preloadOffers.statusText=this.statusText}};xhttp.ontimeout=function(){window.preloadOffers.succeed=false;dispatchPreloadOffersEvent("preloadOffers")};xhttp.open("POST",preloadUrl,true);xhttp.setRequestHeader("Content-Type","application/json;charset=UTF-8");xhttp.timeout=4e3;xhttp.send()}} </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_0"); </script>  <style data-inline-file-name='header.min.css' data-inline-site='tf'>/* Hash: 468bd07150dbbf Source: /tf/css/dist/header.min.css */ @charset "UTF-8";@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.woff2) format("woff2");font-weight:lighter;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.woff2) format("woff2");font-weight:100;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.woff2) format("woff2");font-weight:200;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.woff2) format("woff2");font-weight:300;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.woff2) format("woff2");font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.woff2) format("woff2");font-weight:400;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-56Italic.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-56Italic.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-56Italic.woff2) format("woff2");font-weight:400;font-style:italic;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.woff2) format("woff2");font-weight:500;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.woff2) format("woff2");font-weight:600;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.woff2) format("woff2");font-weight:700;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.woff2) format("woff2");font-weight:800;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.woff2) format("woff2");font-weight:900;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.woff2) format("woff2");font-weight:700;font-style:normal;font-display:swap}body.overflow-hidden{overflow:hidden;position:fixed;width:100%}#recommendation-overlay-content{margin-top:16px}.border-bottom{border-bottom:1px solid #dcdcdc}.hidden{display:none}.loading-wheel-sm.hidden{display:none}.contents{margin:0 auto}.pdp-alert .pdp-banners{z-index:9004}.pdp-main{padding-top:10px}.pdp-main .c-section{margin-top:0}.headerMiddleContent{width:100%;flex-grow:3;flex-shrink:1;flex-basis:100%}#header-offer-bar{position:relative;background:#fff;z-index:81}header .dm-dynamic-offer.dm-img-bkg.cmp-teaser{border:none;position:inherit}header .main-header-container .info-container ul li.account .create-account .loyalty-text{font-weight:700}header .main-header-container .info-container ul li.account .create-account .loyalty-text a{color:#222;font-size:14px;line-height:22px}header .info-container #notification-dd .c-loader{margin:125px 200px}header .info-container #cart-sidebar .c-loader{margin:300px 200px}body.has-messaging-bar header{top:35px}.header-separator{height:0}header{width:100%;border-bottom:1px solid #dcdcdc;position:fixed;background-color:#fff;font-size:14px;line-height:22px;top:0;left:0;right:0;z-index:80}header #dr-activity-banner{background:#fff;color:red;background-color:#ff0;font-weight:600;width:100%;font-size:12px;text-align:center;z-index:80;border-bottom:1px solid #ccc;top:0;left:0;right:0}header #dr-activity-banner .dr-activity-message{display:inline-block;padding:0 2px}header #messagingBar{background:#fff;color:#666;width:100%;line-height:35px;height:35px;font-size:15px;text-align:left;z-index:80;border-bottom:1px solid #ccc;top:0;left:0;right:0;position:fixed}header #messagingBar .messaging-bar-snippet{overflow:auto;display:inline-block;padding:0 2px}header #messagingBar .messaging-bar-snippet img{height:24px;width:auto;margin-top:-2px}header #messagingBar .container{width:1408px}header .main-header-container{max-width:1440px;margin:auto;padding:0 24px;display:flex;align-items:center;justify-content:center;height:60px;position:relative}header .scms-container{max-width:1440px;margin:auto;padding:8px 24px 0;line-height:26px;color:#70707a}header .scms-container span{padding-right:12px;margin-right:6px;border-right:#222 solid 1px}header .nav-container{margin-left:auto;display:flex;align-self:center;min-width:186px;flex-grow:1;flex-shrink:1;flex-basis:0;transition:min-width .2s ease;padding:0;background:#fff}header .nav-container span:focus-visible{outline:2px solid #802eff}header .nav-container .hamburger-btn{position:relative;width:32px;height:32px;margin-right:18px;margin-top:12px;border:3px solid #fff}header .nav-container .hamburger-btn .icon{position:absolute;height:3px;width:24px;top:12px;left:1px;background-color:#222;display:inline-block}header .nav-container .hamburger-btn .icon:before{transition-duration:.5s;position:absolute;width:24px;height:3px;background-color:#222;content:"";top:-8px}header .nav-container .hamburger-btn .icon:after{transition-duration:.5s;position:absolute;width:24px;height:3px;background-color:#222;content:"";top:8px}header .nav-container .hamburger-btn:hover{cursor:pointer}header .nav-container .hamburger-btn:focus-visible{outline:2px solid #802eff}header .nav-container .logo{width:fit-content;height:fit-content}header .nav-container .logo:focus-visible{outline:2px solid #802eff}header .nav-container .logo svg{width:114px;margin-top:-2px}header .nav-container .logo img{max-width:117px;width:100%;max-height:42px;height:auto;margin-top:12px;margin-left:-8px}header .nav-container .mega-nav{background-color:#fff;padding:0 54px;position:fixed;top:0;left:0;bottom:0;visibility:hidden;transform:translate(-110%);z-index:998;transition:.5s;max-width:380px;overflow:auto;width:100%}header .nav-container .mega-nav.open .account-dd{display:none}header .nav-container .mega-nav.open .sign-out{display:none}header .nav-container .mega-nav .main-nav,header .nav-container .mega-nav .sign-out,header .nav-container .mega-nav .support{display:block}header .nav-container .mega-nav .create-account .display-4{display:inline-block}header .nav-container .mega-nav.account-open .main-nav,header .nav-container .mega-nav.account-open .sign-out,header .nav-container .mega-nav.account-open .support{display:none}header .nav-container .mega-nav.account-open .create-account .display-4{display:none}header .nav-container .mega-nav.account-open .account-dd #sidenav-account-details{display:inline-block}header .nav-container .mega-nav.account-open .account-dd #sidenav-account-details ul{padding-inline-start:0}header .nav-container .mega-nav.account-open .account-dd #sidenav-account-details ul li a{padding-top:16px;font-weight:400;font-size:16px;line-height:26px;color:#1b1b1d}header .nav-container .mega-nav.account-open .account .create-account .sidenav-myaccount a{font-weight:500;font-size:22px;line-height:28px;color:#222;position:relative}header .nav-container .mega-nav.account-open .account .create-account .sidenav-myaccount .arrow{width:16px;position:absolute;left:-32px;top:12px;display:inline-block;height:2px;background-color:#222}header .nav-container .mega-nav.account-open .account .create-account .sidenav-myaccount .arrow::after,header .nav-container .mega-nav.account-open .account .create-account .sidenav-myaccount .arrow::before{content:"";position:absolute;width:12px;height:2px;left:-1px;background-color:#222;z-index:-1}header .nav-container .mega-nav.account-open .account .create-account .sidenav-myaccount .arrow::after{top:-4px;transform:rotate(-45deg)}header .nav-container .mega-nav.account-open .account .create-account .sidenav-myaccount .arrow::before{top:4px;transform:rotate(45deg)}header .nav-container .mega-nav .close{top:24px;right:24px}header .nav-container .mega-nav .close:hover{cursor:pointer}header .nav-container .mega-nav a{text-decoration:none;color:#222;display:block}header .nav-container .mega-nav a:active,header .nav-container .mega-nav a:hover{text-decoration:underline;cursor:pointer}header .nav-container .mega-nav .account{margin-top:36px}header .nav-container .mega-nav .account .user-name{font-weight:100;font-size:30px;line-height:38px;color:#2b2b30;margin-bottom:29px}header .nav-container .mega-nav .account .my-account{font-weight:400;font-size:16px;line-height:26px;padding-bottom:12px;color:#1b1b1d}header .nav-container .mega-nav .account .create-account{padding:14px 0}header .nav-container .mega-nav .account .create-account li{padding-bottom:16px}header .nav-container .mega-nav .account .create-account .sidenav-myaccount a{font-weight:400;font-size:16px;color:#1b1b1d}header .nav-container .mega-nav .account .create-account a{font-weight:400;font-size:14px;line-height:26px;padding-bottom:16px;display:inline;color:#0071d0}header .nav-container .mega-nav .account .create-account ul{list-style:none;margin:0}header .nav-container .mega-nav .account .create-account.open .my-account-text{font-weight:500;font-size:22px;line-height:28px}header .nav-container .mega-nav .main-nav{font-weight:500;font-size:22px;line-height:28px;list-style-type:none;margin-left:0;padding-inline-start:0;margin-block-start:0;margin-top:0}header .nav-container .mega-nav .main-nav-item{padding:16px 0;line-height:22px}header .nav-container .mega-nav .main-nav-item.create-account{margin-top:-45px}header .nav-container .mega-nav .main-nav-item.create-account .arrow{display:none}header .nav-container .mega-nav .main-nav-item.create-account .title{font-weight:400;font-size:16px;line-height:26px}header .nav-container .mega-nav .main-nav-item a:active,header .nav-container .mega-nav .main-nav-item a:visited{color:#54545c}header .nav-container .mega-nav .main-nav-item:hover{cursor:pointer}header .nav-container .mega-nav .main-nav-item.open{padding:0 36px;margin-left:-36px;margin-top:24px;padding-right:0;padding-bottom:14px}header .nav-container .mega-nav .main-nav-item.open .arrow{width:16px;position:absolute;left:16px;top:90px;display:inline-block;height:2px;background-color:#222}header .nav-container .mega-nav .main-nav-item.open .arrow::after,header .nav-container .mega-nav .main-nav-item.open .arrow::before{content:"";position:absolute;width:12px;height:2px;left:-1px;background-color:#222;z-index:-1}header .nav-container .mega-nav .main-nav-item.open .arrow::after{top:-4px;transform:rotate(-45deg)}header .nav-container .mega-nav .main-nav-item.open .arrow::before{top:4px;transform:rotate(45deg)}header .nav-container .mega-nav .sub-nav{transform:translate(0,0);animation:delayedFadeIn .4s;visibility:hidden;display:none;font-weight:400;font-size:16px;line-height:42px;list-style-type:none;padding-inline-start:0;position:absolute;background-color:#fff;margin:24px 24px 24px 0;padding-right:24px;z-index:-1;padding-bottom:42px}header .nav-container .mega-nav .sub-nav li a{line-height:22px;padding:10px 0}header .nav-container .mega-nav .sub-nav .popular-image{height:74px;width:112px;object-fit:cover;display:inline-block}header .nav-container .mega-nav .sub-nav .see-all{margin-bottom:36px;position:absolute;color:#0071d0!important;max-width:290px}header .nav-container .mega-nav .sub-nav .see-all a{color:inherit}header .nav-container .mega-nav .sub-nav .see-all .right-arrow{position:absolute;height:3px;width:16px;bottom:18px;margin-left:15px;background-color:#0071d0}header .nav-container .mega-nav .sub-nav .see-all .right-arrow::after,header .nav-container .mega-nav .sub-nav .see-all .right-arrow::before{content:"";position:absolute;width:11px;height:3px;right:-4px;background-color:#0071d0}header .nav-container .mega-nav .sub-nav .see-all .right-arrow::after{top:-3px;transform:rotate(45deg)}header .nav-container .mega-nav .sub-nav .see-all .right-arrow::before{top:3px;transform:rotate(-45deg)}header .nav-container .mega-nav .sign-out{margin-bottom:142px;margin-top:24px}header .nav-container .mega-nav .sign-out a{color:#0071d0}header .nav-container .mega-nav.open .account{overflow:hidden;animation:fadeIn .5s}header .nav-container .mega-nav.open li{display:none}header .nav-container .mega-nav.open li.open{display:block}header .nav-container .mega-nav.open li.open .sub-nav{visibility:visible;display:block;animation:delayedFadeIn 1.2s ease-in}header .nav-container .mega-nav.open li.open .sub-nav li{display:block}header .nav-container .mega-nav.open li.open .sub-nav li.popular{display:flex;align-items:center}header .nav-container .mega-nav.open .main-nav{border-bottom:1px solid #dcdcdc;padding-left:36px;margin-left:-36px}header .nav-container .mega-nav .support{font-weight:400;font-size:16px;line-height:26px;list-style-type:none;margin-left:0;margin-top:0;padding-inline-start:0;margin-block-end:0;max-width:280px}header .nav-container .mega-nav .support li{margin-top:16px}header .nav-container.open .mega-nav{transform:translate(0);visibility:visible;box-shadow:0 18px 18px rgba(0,0,0,.3)}header .search-container{align-self:center;padding:16px;display:flex;position:relative;width:100%}header .search-container .search-layout{padding:16px 36px;width:100%;display:none}header .search-container .search .search-button{border-radius:0 3px 3px 0;margin:0;text-align:center;filter:none;outline:0;border:none;height:50px;width:100px;background:#4a4a4a}header .search-container .search .search-button:hover{cursor:pointer}header .search-container .search-icon{width:30px;position:absolute;right:12px;top:4px}header .search-container .search-icon:hover{cursor:pointer}header .search-container .search-icon .cls-1{fill:#54545c}header .search-container.open .search{display:block;visibility:visible;opacity:1;position:fixed;z-index:1000;top:0;left:0;height:100%;width:100%;background-color:#fff;animation:fadeIn .5s}header .search-container.open .search-layout{padding:16px 36px;display:block}header .search-container .close{display:none}header .info-container{position:relative;width:auto;opacity:1;flex-grow:1;flex-shrink:1;flex-basis:0}header .info-container a{color:#222;cursor:pointer}header .info-container ul{list-style-type:none;display:flex;padding-inline-start:0;align-items:center;justify-content:center;margin:0}header .info-container ul li{display:inline-block;padding:0 12px;width:max-content}header .info-container ul li.order-status{display:none}header .info-container ul li.quick-order{display:none}header .info-container ul li.cart{margin-right:-16px}header .info-container ul li.cart a{height:42px;width:42px;display:inline-block;margin-left:-2px}header .info-container ul li.cart a svg{height:32px;width:32px;display:inline-block}header .info-container ul li.bell,header .info-container ul li.cart{width:52px;margin-bottom:-10px;position:relative}header .info-container ul li.bell:hover,header .info-container ul li.cart:hover{cursor:pointer}header .info-container ul li.bell.active,header .info-container ul li.cart.active{border-bottom:3px solid #e71316;margin-bottom:-13px}header .info-container ul li.bell a:focus,header .info-container ul li.cart a:focus{outline:0}header .info-container ul li.bell .cls-1,header .info-container ul li.cart .cls-1{fill:#54545c}header .info-container ul li.bell .alert,header .info-container ul li.cart .alert{border-radius:50%;background-color:#e71316;border:#fff solid 1px;position:absolute;display:inline-block;height:12px;width:12px;right:12px;padding:0}header .info-container ul li.bell .count,header .info-container ul li.cart .count{color:#e71316;font-size:11px;font-weight:700;position:absolute;display:inline-block;right:19px;top:-11px}header .info-container ul li.bell{margin-bottom:-8px}header .info-container ul li.account{display:none;position:relative;margin-bottom:-2px}header .info-container ul li.account:hover{cursor:pointer}header .info-container ul li.account.open::after{content:" ";position:absolute;bottom:-3px;height:3px;background-color:#e71316;width:100%;left:0;z-index:83}header .info-container ul span#logged-in-toggle::after,header .info-container ul span#sign-in-toggle::after{content:"▼";font-size:8px;margin-left:6px;display:inline-block;color:#54545c}header .info-container .cart-dd{transform:translate(110%);transition:.5s;visibility:hidden;position:fixed;z-index:1000;background-color:#fff;right:0;top:0;width:100%;height:100%;max-width:440px;overflow-y:scroll;padding:32px 24px;overscroll-behavior:contain}header .info-container .cart-dd-header{font-weight:500;font-size:22px;line-height:28px;color:#1b1b1d}header .info-container .cart-dd-header .close{right:16px;top:24px}header .info-container .cart-dd-body .lable{margin-top:32px;font-weight:500;font-size:18px;line-height:22px}header .info-container .cart-dd-body .product{font-weight:400;margin-top:24px}header .info-container .cart-dd-body .product .image{height:50px;width:50px;background-color:#a2a2a2;display:inline-block;float:left}header .info-container .cart-dd-body .product .info{width:100%;padding-left:66px;font-weight:400}header .info-container .cart-dd-body .product .info .title a{font-weight:400;font-size:14px;line-height:20px;color:#0071d0}header .info-container .cart-dd-body .product .info .bold{font-weight:600}header .info-container .cart-dd-body .product .info .contactUsLink{color:#0071d0}header .info-container .cart-dd-body .product .info .special-offer-wrapper{margin-top:8px}header .info-container .cart-dd-body .product .info .special-offer-wrapper .finalPrice{font-size:16px;font-weight:500}header .info-container .cart-dd-body .product .info .special-offer-wrapper .strikeThroughPrice{margin-left:5px;color:#70707a}header .info-container .cart-dd-body .product .info .special-offer-wrapper .absoluteSave{color:#01891e;font-weight:500;font-size:12px}header .info-container .cart-dd-body .product .info .special-offer-wrapper .specialOfferEndDate{color:#70707a;font-weight:500;font-size:12px}header .info-container .cart-dd-body .product .info .special-offer-wrapper .tooltip{position:relative;display:inline-block}header .info-container .cart-dd-body .product .info .special-offer-wrapper .tooltip .icon-wrapper{display:inline-block;margin-left:5px}header .info-container .cart-dd-body .product .info .special-offer-wrapper .tooltip .tooltiptext{display:block;visibility:hidden;position:absolute;top:100%;left:50%;transform:translate(-50%,10px);width:max-content;max-width:220px;background-color:#fff;border:1px solid #ddd;border-radius:3px;color:#000;padding:10px;text-align:center;z-index:1;opacity:0;transition:opacity .3s;box-shadow:0 6px 8px 0 rgba(13,13,13,.1)}header .info-container .cart-dd-body .product .info .special-offer-wrapper .tooltip .tooltiptext::before{content:"";position:absolute;top:-9px;left:calc(50% - 5px);border-left:1px solid #ddd;border-top:1px solid #ddd;transform:rotate(45deg);width:16px;height:16px;background:#fff}header .info-container .cart-dd-body .product .info .special-offer-wrapper .tooltip .tooltiptext .signInLink{color:#0071d0}header .info-container .cart-dd-body .product .info .special-offer-wrapper .tooltip:hover .tooltiptext{visibility:visible;opacity:1}header .info-container .cart-dd-footer .subtotal{font-weight:500;font-size:18px;line-height:28px}header .info-container .cart-dd-footer .price{font-weight:200;font-size:22px}header .info-container .cart-dd-footer a{display:inline-block;color:#0071d0}header .info-container .cart-dd-footer .offer{box-shadow:0 2px 4px rgba(34,34,34,.1)}header .info-container .cart-dd-footer .offer #recommendation-overlay{position:fixed;display:none;background:#fff;top:0;padding:16px;right:0;left:0;z-index:1;height:100vh;min-height:1200px}header .info-container .cart-dd-footer .offer #recommendation-overlay.open{display:block}header .info-container .cart-dd-footer .offer #recommendation-overlay .back{font-weight:500;font-size:14px;line-height:22px;color:#0071d0;margin-bottom:24px;padding-left:18px}header .info-container .cart-dd-footer .offer #recommendation-overlay .back .arrow{width:12px;position:absolute;left:16px;top:26px;display:inline-block;height:2px;background-color:#0071d0}header .info-container .cart-dd-footer .offer #recommendation-overlay .back .arrow::after,header .info-container .cart-dd-footer .offer #recommendation-overlay .back .arrow::before{content:"";position:absolute;width:9px;height:2px;left:-1px;background-color:#0071d0;z-index:-1}header .info-container .cart-dd-footer .offer #recommendation-overlay .back .arrow::before{top:3px;transform:rotate(45deg)}header .info-container .cart-dd-footer .offer #recommendation-overlay .back .arrow::after{top:-3px;transform:rotate(-45deg)}header .info-container .cart-dd-footer .offer #recommendation-overlay .back:hover{cursor:pointer}header .info-container .cart-dd-footer .offer #recommendation-overlay a.button.btn-featured{color:#fff;line-height:40px;padding:0 16px;background-color:#e71316;border:1px solid #e71316;border-radius:3px}header .info-container .cart-dd-footer .suggested-products{background-color:#f7f7f7;padding:24px;margin:0 -24px}header .info-container .cart-dd-footer .suggested-products .title{font-weight:400;font-size:16px;line-height:20px;margin-bottom:16px}header .info-container .cart-dd-footer .suggested-products .product{background:#fff;border:1px solid #e5e5e5;border-radius:3px;padding:16px}header .info-container .cart-dd-footer .suggested-products .product .line{display:flex;align-items:center;justify-content:space-between;flex-direction:row}header .info-container .cart-dd-footer .suggested-products .product .line .image{width:50px;height:auto}header .info-container .cart-dd-footer .suggested-products .product .line .image img{max-width:100%;max-height:100%}header .info-container .cart-dd-footer .suggested-products .product .line .label{padding:0 16px;font-weight:700;font-size:14px;line-height:22px;color:#008ceb;width:100%;white-space:inherit;background-color:#fff}header .info-container .cart-dd-footer .suggested-products .product .line .qty{min-width:80px;text-align:right}header .info-container .cart-dd-footer .suggested-products .product .line .qty span{font-weight:400;font-size:14px;line-height:12px;text-align:center;color:#54545c;padding-right:8px}header .info-container .cart-dd-footer .suggested-products .product .line .qty input{background:#fff;border:1px solid #dcdcdc;border-radius:3px;width:34px;height:34px}header .info-container .cart-dd-footer .suggested-products .product .description{font-weight:400;font-size:12px;line-height:15px;color:#61616b;padding:4px 0}header .info-container .cart-dd-footer .suggested-products .product .info{display:flex;justify-content:space-between}header .info-container .cart-dd-footer .suggested-products .product .info .price{font-weight:200;font-size:14px;line-height:22px}header .info-container .cart-dd-footer .suggested-products .product .info .cmp-p-ctaitem{margin-top:-12px}header .info-container .cart-dd-footer .suggested-products .product .info .cmp-p-ctaitem.m--small .cmp-ctaitem{padding:0 16px}header .info-container .cart-dd-footer .cmp-p-ctaitem.m--block .cmp-ctaitem .shopping--btn{color:#0071d0;width:100%;display:block}header .info-container .cart-dd-footer .cmp-p-ctaitem.m--block .cmp-ctaitem__anchor{width:100%}header .info-container .cart-dd-footer .cmp-p-ctaitem.m--block .cmp-ctaitem{padding:0}header .info-container .cart-dd .float-right{float:right}header .info-container .cart-dd .no-product{text-align:center;color:#000;padding:72px 0}header .info-container .cart-dd.open{transform:translate(0);visibility:visible}header .info-container .bell-dd{overflow-y:scroll;box-shadow:0 4px 6px rgba(0,0,0,.1);background-color:#fff;overscroll-behavior:contain}header .info-container .bell-dd a{color:#0071d0}header .info-container .bell-dd-header{font-weight:500;font-size:22px;line-height:28px;padding:63px 36px 16px;border-bottom:1px solid #dcdcdc;background-color:#fff}header .info-container .bell-dd-header a{font-weight:400;font-size:14px;line-height:22px;display:inline;float:right;padding-top:4px}header .info-container .bell-dd-body .notification{padding:36px 36px 36px;font-weight:200;font-size:14px;line-height:22px;border-bottom:1px solid #dcdcdc;background-color:#fff}header .info-container .bell-dd-body .notification .body{position:relative}header .info-container .bell-dd-body .notification.new{background-color:#f7f7f7}header .info-container .bell-dd-body .notification .label{font-weight:700;font-size:12px;line-height:22px;color:#81828c;padding:0 0 6px 0;display:block;background-color:transparent}header .info-container .bell-dd-body .notification .time{font-weight:400;font-size:12px;line-height:22px;float:right}header .info-container .bell-dd-body .notification a{display:inline}header .info-container .bell-dd-body .notification a .label:hover{text-decoration:none}header .info-container .bell-dd-body .notification a .body{padding-right:30px;position:relative;color:#1b1b1d}header .info-container .bell-dd-body .notification a .body:hover{color:#0071d0;text-decoration:underline;cursor:pointer}header .info-container .bell-dd-body .notification .bin{width:20px;position:absolute;top:0;right:0;fill:#92929e}header .info-container .bell-dd-footer{font-weight:500;font-size:14px;line-height:22px}header .info-container .bell-dd.open{display:block;visibility:visible;opacity:1;position:fixed;z-index:1000;height:100%;width:100%;top:0;left:0;right:0;animation:fadeIn .5s}header .bell-dd,header .search{display:none;visibility:hidden;opacity:0}header .account-dd #sidenav-account-details{display:none}header .account-dd .open #sidenav-account-details{display:inline-block}header .close{position:absolute;right:36px;top:20px;width:42px;height:42px;opacity:1}header .close:hover{opacity:.5}header .close:before{transform:rotate(45deg)}header .close:after{transform:rotate(-45deg)}header .close:after,header .close:before{position:absolute;left:20px;content:" ";height:24px;width:3px;background-color:#1b1b1d;transition:visibility 0s,opacity .5s linear}header.open .full-bg{opacity:1;visibility:visible;display:block}header .full-bg{opacity:0;visibility:hidden;display:none;position:fixed;content:"";z-index:81;top:0;left:0;width:100%;height:100%;background-color:rgba(0,0,0,.5);transition:visibility 0s,opacity .5s linear}header .full-bg.open{opacity:1;visibility:visible;display:block}header .full-bg.open-top{top:112px}header .search-bg{opacity:0;visibility:hidden;display:none;position:fixed;content:"";z-index:81;left:0;width:100%;height:100%;background-color:rgba(0,0,0,.5);transition:visibility 0s,opacity .5s linear}header .search-bg.open{opacity:1;visibility:visible;display:block}header .c-alert{position:relative;display:inline-block;padding:24px 16px 24px 42px;color:#222;border:1px solid #dcdcdc;margin-top:32px}header .c-alert--warning{border-left:8px solid #f76c1f}header .c-alert__title{font-size:16px;padding-right:6px;font-weight:900}header .c-alert__desc{font-size:16px}header .c-alert__icon{width:24px;height:24px;position:absolute;left:12px}header a:hover{text-decoration:underline}@media (min-width:576px){header .info-container .bell-dd-header{padding:63px 76px 16px}header .info-container .bell-dd-body .notification{padding:36px 76px 36px}}@media (min-width:768px){header .info-container .bell-dd-header{padding:63px 146px 16px}header .info-container .bell-dd-body .notification{padding:36px 146px 36px}}@media (min-width:992px){header.project-header{z-index:0}header .main-header-container{height:76px}header .main-header-container .nav-container .mega-nav .close{top:24px;right:24px}header .main-header-container .search-container .search-layout{margin-right:0}header .main-header-container .info-container{width:100%}header .main-header-container .info-container ul li.order-status{display:inline-block}header .main-header-container .info-container ul li.quick-order{display:inline-block}header .main-header-container .info-container ul li.account{display:inline-block}header .main-header-container .info-container ul li.account .sing-out a{color:#0071d0}header .main-header-container .info-container ul li.account .create-account .loyalty-text{font-weight:700}header .main-header-container .info-container ul li.account .create-account .loyalty-text a{color:#222;font-size:14px;line-height:22px}header .main-header-container .info-container ul li.account .create-account a{display:inline;color:#0071d0}header .main-header-container .info-container ul li.account .create-account ul li a{color:#1b1b1d}header .main-header-container .info-container ul li.account .create-account .sing-out a{color:#0071d0}header .main-header-container .info-container ul li.account .create-account .points{margin-top:-10px}header .main-header-container .info-container ul li.account .create-account .points a{color:#70707a;font-size:14px;line-height:22px}header .main-header-container .info-container ul li.account.open .account-dd{display:inline-block;padding:36px;top:27px;right:-2px;height:auto;overflow-y:scroll;max-height:80vh;overflow-x:hidden;overscroll-behavior:contain}header .main-header-container .info-container ul li.account.open .account-dd ul{display:block;padding-left:0;font-size:16px;line-height:26px;margin-left:-10px}header .main-header-container .info-container ul li.account.open .account-dd ul li{padding-top:8px;display:block;width:auto}header .main-header-container .info-container ul li.account.active{border-bottom:3px solid #e71316;margin-bottom:-7px}header .main-header-container .info-container ul li.cart{margin-right:-16px}header .main-header-container .search .close{opacity:0}header .main-header-container.open .info-container{width:0;opacity:0;flex-grow:0}header .main-header-container.open .info-container ul{pointer-events:none}header .main-header-container.open .nav-container{min-width:152px;transition:min-width .2s ease}header .main-header-container.open .nav-container .menu{width:0}header .main-header-container.open .nav-container .menu .icon{display:none}header .main-header-container.open .search-container{width:100%;margin-right:48px}header .main-header-container.open .search-layout{margin-right:32px}header .main-header-container.open .close{display:inline-block;position:absolute;right:0;animation:delayedFadeIn .7s;opacity:1;z-index:1001;padding:10px;margin-left:5px}header .main-header-container.open .close:hover{opacity:.5;cursor:pointer}header .main-header-container.open .close:focus-visible{outline:2px solid #802eff}header .nav-container .logo svg{width:136px;height:76px;margin-top:-8px}header .nav-container .logo svg .tf-logo-cls-1{fill:#e71316}header .nav-container .logo svg .tf-logo-cls-2{fill:#fff}header .nav-container .logo img{max-width:140px;width:100%;max-height:46px;height:auto;margin-top:12px;margin-left:0}header .nav-container .logo .scms{margin-top:10px;width:150px;margin-left:-8px}header .nav-container .hamburger-btn{margin-top:20px}header .nav-container .mega-nav{padding:0 74px 0 74px;overflow-x:hidden;min-width:380px}header .nav-container .mega-nav span:focus-visible{outline:2px solid #802eff}header .nav-container .mega-nav .main-nav{margin-top:24px}header .nav-container .mega-nav .main-nav-item{display:block;width:308px}header .nav-container .mega-nav .main-nav-item:hover{color:#005daa}header .nav-container .mega-nav .main-nav-item.open{border-bottom:1px solid #dcdcdc;border-top:1px solid #dcdcdc;background-color:#fff;display:block;padding:15px 0;margin-left:0;margin-top:0;padding-right:16px;padding-bottom:14px}header .nav-container .mega-nav .main-nav-item.open::after{content:"";display:block!important;position:absolute;top:0;right:0;border-right:2px solid #fff;height:100%}header .nav-container .mega-nav .main-nav-item.open .sub-nav{left:380px;top:36px;background-color:#fff;padding:0 42px;border-left:1px solid #dcdcdc;visibility:visible;transform:translate(0);display:block;margin-left:0;padding-bottom:42px}header .nav-container .mega-nav .main-nav-item.open .sub-nav li{display:block}header .nav-container .mega-nav .main-nav-item.open .arrow,header .nav-container .mega-nav .main-nav-item.open::after,header .nav-container .mega-nav .main-nav-item.open::before{display:none}header .nav-container .mega-nav .main-nav-item.open .main-nav{border-bottom:none;padding-left:0;margin-left:0}header .nav-container .mega-nav.open{min-width:760px}header .nav-container .mega-nav.open li{display:block}header .nav-container .mega-nav.open .account{max-height:0;transition:max-height .15s ease-out;overflow:hidden;animation:fadeIn .5s}header .nav-container .mega-nav.open .main-nav{border-bottom:none;width:340px}header .nav-container .mega-nav.close .pragma-toggle:hover{cursor:pointer}header .nav-container .mega-nav.close:hover{cursor:pointer}header .nav-container .mega-nav .account{display:none}header .nav-container .mega-nav .support .dt-hide{display:none}header .nav-container .mega-nav .sign-out{border-top:none}header .nav-container .mega-nav .sign-out a{display:none}header .nav-container .mega-nav .logo img{margin-top:32px;max-width:142px;margin-left:0}header .info-container .bell-dd{border:1px solid #d8d8d8;border-radius:4px;background-color:#fff}header .info-container .bell-dd-header{padding:18px 26px 16px 28px;color:#1b1b1d}header .info-container .bell-dd-header .close{display:none}header .info-container .bell-dd-body .notification{padding:24px;font-size:14px;line-height:22px;font-weight:400}header .info-container .bell-dd-body .notification .label{color:#54545c}header .info-container .bell-dd-body .notification .body{color:#1b1b1d;position:relative}header .info-container .bell-dd-body .notification.new:hover .body{color:#0071d0;text-decoration:underline;cursor:pointer}header .info-container .bell-dd-footer{padding:24px}header .info-container .bell-dd.open{position:absolute;top:36px;left:auto;right:32px;height:auto;max-height:calc(100vh - 140px);width:420px}header .info-container .account-dd{position:absolute;width:330px;background:#fff;border:1px solid #d8d8d8;box-sizing:border-box;box-shadow:0 4px 6px rgba(0,0,0,.1);border-radius:4px;display:none;z-index:999}header .info-container .account-dd .account{padding-left:0;padding-right:0;text-align:left}header .info-container .account-dd .create-account .display-4{word-break:break-all;border-bottom:1px solid #dcdcdc}header .search-container{align-self:center;position:relative;transition:1s}header .search-container .search{display:block;visibility:visible;opacity:1;width:100%;padding:0;height:50px}header .search-container .search-layout{display:flex;padding:0}header .search-container .search-icon{display:none}header .account-dd #sidenav-account-details{display:inline-block}header .search-bg{top:96px}header body.has-messaging-bar{top:112px}}@media (prefers-reduced-motion){.hamburger-btn{animation:none!important}.logo{animation:none!important}}.mega-nav{animation:none!important}@keyframes fadeIn{0%{opacity:0;display:none}100%{opacity:1;display:block}}@keyframes fadeOut{0%{opacity:1}100%{opacity:0}}@keyframes delayedFadeIn{0%{display:none;opacity:0}80%{display:block;opacity:1}}.sr-only{display:none}#notification-body .body{position:relative}#notification-body .content{padding:0 20px 0 0!important;display:inline-block}footer,header{font-family:HelveticaNeue,sans-serif;-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%;max-width:100%;scroll-behavior:smooth;color:#1b1b1d;margin:0}footer *,header *{-webkit-box-sizing:border-box;-moz-box-sizing:border-box;box-sizing:border-box}footer :after,footer :before,header :after,header :before{-webkit-box-sizing:border-box;-moz-box-sizing:border-box;box-sizing:border-box}footer :focus-visible,header :focus-visible{outline:2px solid #802eff}footer input:focus-visible,header input:focus-visible{outline:0}footer .bold-label,header .bold-label{font-weight:700}footer .h1,footer .h2,footer .h3,footer .h4,footer .h5,footer .h6,footer body,footer h1,footer h2,footer h3,footer h4,footer h5,footer h6,header .h1,header .h2,header .h3,header .h4,header .h5,header .h6,header body,header h1,header h2,header h3,header h4,header h5,header h6{color:#222}footer .text-light,footer .text-light .display-1,footer .text-light .display-2,footer .text-light .display-3,footer .text-light .display-4,footer .text-light .h1,footer .text-light .h2,footer .text-light .h3,footer .text-light .h4,footer .text-light .h5,footer .text-light .h6,footer .text-light body,footer .text-light h1,footer .text-light h2,footer .text-light h3,footer .text-light h4,footer .text-light h5,footer .text-light h6,header .text-light,header .text-light .display-1,header .text-light .display-2,header .text-light .display-3,header .text-light .display-4,header .text-light .h1,header .text-light .h2,header .text-light .h3,header .text-light .h4,header .text-light .h5,header .text-light .h6,header .text-light body,header .text-light h1,header .text-light h2,header .text-light h3,header .text-light h4,header .text-light h5,header .text-light h6{color:#fff}footer body,header body{margin:0;font-size:16px;line-height:26px}footer p,header p{margin-top:0;margin-bottom:0;font-size:16px;line-height:26px}footer .p-grey,header .p-grey{color:#54545c}footer .text-center,header .text-center{text-align:center}footer .alt,header .alt{font-size:16px;line-height:26px}footer .text-size-14,header .text-size-14{font-size:14px;line-height:22px}footer a,header a{text-decoration:none;color:#1b1b1d}footer a:hover,header a:hover{text-decoration:none;color:#1b1b1d}footer a:visited,header a:visited{text-decoration:none;color:#1b1b1d}footer .disabled,header .disabled{color:#a2a2a2}footer .label-medium,header .label-medium{color:#222;font-size:16px;line-height:26px;font-weight:400}footer .label-bold,header .label-bold{color:#222;font-size:16px;line-height:26px;font-weight:bolder}footer .hint,header .hint{font-size:14px;line-height:30.727268px}footer .blockquote,header .blockquote{color:#222;font-size:20.571424px;line-height:33.090902px;margin-bottom:0}footer .alt-color,header .alt-color{color:#54545c}footer .success,header .success{color:#3bad2f}footer .warning,header .warning{color:#ed7700}footer .error,header .error{color:#e71316}footer .thin,header .thin{font-weight:lighter}footer .light,header .light{font-weight:300}footer .italic,header .italic{font-style:italic}footer .medium,header .medium{font-weight:700}footer .bold,header .bold{font-weight:bolder}footer .h1,footer .h2,footer .h3,footer .h5,footer h1,footer h2,footer h3,footer h5,header .h1,header .h2,header .h3,header .h5,header h1,header h2,header h3,header h5{font-weight:400;margin:0;padding-bottom:10px}footer .h4,footer h4,header .h4,header h4{font-weight:600;margin:0;padding-bottom:10px}footer .h6,footer h6,header .h6,header h6{font-weight:400;margin:0;padding-bottom:10px}footer .display-1,footer .display-2,footer .display-3,footer .display-4,header .display-1,header .display-2,header .display-3,header .display-4{font-family:HelveticaNeueLight,Helvetica,Roboto,"Segoe UI",Arial,sans-serif;font-weight:lighter}footer .h1,footer h1,header .h1,header h1{font-size:32px;line-height:40px}footer .h2,footer h2,header .h2,header h2{font-size:26px;line-height:33px}footer .h3,footer h3,header .h3,header h3{font-size:22px;line-height:28px}footer .h4,footer h4,header .h4,header h4{font-size:20px;line-height:25px}footer .h5,footer h5,header .h5,header h5{font-size:18px;line-height:23px}footer .h6,footer h6,header .h6,header h6{font-size:16px;line-height:20px}footer .display-1,header .display-1{font-size:40px;line-height:50px}footer .display-2,header .display-2{font-size:32px;line-height:40px}footer .display-3,header .display-3{font-size:24px;line-height:30px}footer .display-4,header .display-4{font-weight:300;font-size:30px;line-height:38px}@media (max-width:768px){footer .h1,footer h1,header .h1,header h1{font-size:26px;line-height:33px}footer .h2,footer h2,header .h2,header h2{font-size:21px;line-height:26px}footer .h3,footer h3,header .h3,header h3{font-size:18px;line-height:23px}footer .h4,footer h4,header .h4,header h4{font-size:16px;line-height:20px}footer .h5,footer h5,header .h5,header h5{font-size:16px;line-height:20px}footer .h6,footer h6,header .h6,header h6{font-size:16px;line-height:20px}footer .display-1,header .display-1{font-size:40px;line-height:50px}footer .display-2,header .display-2{font-size:32px;line-height:40px}footer .display-3,header .display-3{font-size:24px;line-height:30px}footer .display-4,header .display-4{font-weight:300;font-size:30px;line-height:38px}}footer .font-size-14,header .font-size-14{font-size:14px}footer .font-size-16,header .font-size-16{font-size:16px}footer .font-size-18,header .font-size-18{font-size:18px}footer .font-size-20,header .font-size-20{font-size:20px}footer .font-size-22,header .font-size-22{font-size:22px}footer .font-size-24,header .font-size-24{font-size:24px}footer .font-size-26,header .font-size-26{font-size:26px}footer fieldset,header fieldset{display:block;margin-inline-start:0;margin-inline-end:0;padding-block-start:0;padding-inline-start:0;padding-inline-end:0;padding-block-end:0;border-width:0;border-style:none}@media print{footer .cmp-p-pageheadinghero,header .cmp-p-pageheadinghero{display:none}footer .cmp-p-manualnav,header .cmp-p-manualnav{display:none}footer .header-cmp,header .header-cmp{display:none}footer .cmp-p-anchorlist,header .cmp-p-anchorlist{display:none}footer .cmp-p-ctaitem,header .cmp-p-ctaitem{display:none}footer .footer,header .footer{display:none}footer .cmp-p-testimonial,header .cmp-p-testimonial{display:none}footer td,footer th,header td,header th{padding-top:4px;padding-bottom:4px;height:30px}}.cmp-ctaitem{margin-top:16px}.cmp-ctaitem__anchor{display:block;color:#0071d0;font-weight:700;font-size:18px}.cmp-ctaitem__anchor:hover{color:#005daa}.cmp-ctaitem__anchor:visited{color:#0071d0}.cmp-ctaitem__icon{float:right;width:24px}.cmp-ctaitem .modal-toggle{cursor:pointer}.cmp-p-ctaitem:hover{cursor:pointer}.cmp-p-ctaitem.m--center{text-align:center}.cmp-p-ctaitem.m--resource{border:1px solid #c9c8c8;border-radius:4px;padding:24px;display:block;font-weight:400;font-size:14px}.cmp-p-ctaitem.m--resource__anchor{display:block;text-decoration:none;color:#0071d0}.cmp-p-ctaitem.m--resource .cmp-ctaitem__icon{top:0;color:#c9c8c8}.cmp-p-ctaitem.m--video .cmp-ctaitem{display:inline-block;text-align:center;margin:0;height:40px;padding:0 24px 0 24px;margin-top:8px;width:auto}.cmp-p-ctaitem.m--video .cmp-ctaitem__anchor{color:#0071d0;font-weight:400}.cmp-p-ctaitem.m--video .cmp-ctaitem .cmp-ctaitem__icon{height:32px;width:32px;margin-top:-3px;border-radius:50%;background-color:#e71316;margin-left:18px;padding-top:5px;color:#fff}.cmp-p-ctaitem.m--btn-primary .cmp-ctaitem{display:inline-block;text-align:center;margin:0;border-radius:3px;font-weight:700;font-size:14px;height:40px;padding:0 24px 0 24px;box-sizing:border-box;line-height:40px;color:#222;width:auto;background-color:#e71316;border:solid 1px #e71316}.cmp-p-ctaitem.m--btn-primary .cmp-ctaitem__anchor{color:#fff;font-size:14px}.cmp-p-ctaitem.m--btn-primary .cmp-ctaitem:hover{background-color:#d01013;border:solid 1px #d01013;cursor:pointer}.cmp-p-ctaitem.m--btn-primary .cmp-ctaitem:active{box-shadow:inset 0 2px 5px 2px #d01013;background-color:#e71316}.cmp-p-ctaitem.m--btn-primary .cmp-ctaitem__icon{margin-top:8px;margin-left:8px}.cmp-p-ctaitem.m--btn-secondary .cmp-ctaitem{display:inline-block;text-align:center;margin:0;border-radius:3px;font-weight:700;font-size:14px;height:40px;padding:0 24px 0 24px;box-sizing:border-box;line-height:40px;color:#222;width:auto;background-color:#555759;border:solid 1px #555759}.cmp-p-ctaitem.m--btn-secondary .cmp-ctaitem__anchor{color:#fff;font-size:14px}.cmp-p-ctaitem.m--btn-secondary .cmp-ctaitem:hover{background-color:#222;border:solid 1px #222}.cmp-p-ctaitem.m--btn-secondary .cmp-ctaitem:active{box-shadow:inset 0 2px 5px 2px #222;background-color:#555759}.cmp-p-ctaitem.m--btn-secondary .cmp-ctaitem__icon{margin-top:8px;margin-left:8px}.cmp-p-ctaitem.m--btn-outline .cmp-ctaitem{display:inline-block;text-align:center;margin:0;border-radius:3px;font-weight:700;font-size:14px;height:40px;padding:0 24px 0 24px;box-sizing:border-box;line-height:40px;color:#222;width:auto;background-color:#fff;border:solid 1px #dcdcdc}.cmp-p-ctaitem.m--btn-outline .cmp-ctaitem__anchor{color:#0071d0;font-size:14px}.cmp-p-ctaitem.m--btn-outline .cmp-ctaitem:hover{background-color:#fff;border:solid 1px #0071d0}.cmp-p-ctaitem.m--btn-outline .cmp-ctaitem:active{box-shadow:inset 0 2px 5px 2px #dcdcdc}.cmp-p-ctaitem.m--btn-outline .cmp-ctaitem__icon{margin-top:8px;margin-left:8px}.cmp-p-ctaitem.m--btn-info .cmp-ctaitem{display:inline-block;text-align:center;margin:0;border-radius:3px;font-weight:700;font-size:14px;height:40px;padding:0 24px 0 24px;box-sizing:border-box;line-height:40px;color:#222;width:auto;color:#555759;background-color:#fff;border:solid 1px #dcdcdc}.cmp-p-ctaitem.m--btn-info .cmp-ctaitem__anchor{color:#555759;font-size:14px}.cmp-p-ctaitem.m--btn-info .cmp-ctaitem:hover{border:solid 1px #555759}.cmp-p-ctaitem.m--btn-info .cmp-ctaitem:active{box-shadow:inset 0 2px 5px 2px #dcdcdc}.cmp-p-ctaitem.m--btn-info .cmp-ctaitem__icon{margin-top:8px;margin-left:8px}.cmp-p-ctaitem.m--btn-white .cmp-ctaitem{display:inline-block;text-align:center;margin:0;border-radius:3px;font-weight:700;font-size:14px;height:40px;padding:0 24px 0 24px;box-sizing:border-box;line-height:40px;color:#222;width:auto;background:0 0;border:solid 1px #fff}.cmp-p-ctaitem.m--btn-white .cmp-ctaitem__anchor{color:#fff;font-size:14px}.cmp-p-ctaitem.m--btn-white .cmp-ctaitem__anchor:hover{color:#222}.cmp-p-ctaitem.m--btn-white .cmp-ctaitem:hover{color:#222;background-color:#fff;border:solid 1px #fff}.cmp-p-ctaitem.m--btn-white .cmp-ctaitem:active{box-shadow:inset 0 2px 5px 2px #dcdcdc}.cmp-p-ctaitem.m--btn-white .cmp-ctaitem__icon{margin-top:8px;margin-left:8px}.cmp-p-ctaitem.m--btn-link .cmp-ctaitem{display:inline-block;text-align:left;margin:0;border-radius:3px;font-weight:700;font-size:14px;height:40px;box-sizing:border-box;line-height:40px;width:auto;border:none;background:0 0;color:#0071d0;padding:0;align-items:center}.cmp-p-ctaitem.m--btn-link .cmp-ctaitem:hover{border:none;color:#005daa}.cmp-p-ctaitem.m--btn-link .cmp-ctaitem:hover .cmp-ctaitem__icon{color:#005daa}.cmp-p-ctaitem.m--btn-link .cmp-ctaitem:active{border:none;background:0 0;color:#262262}.cmp-p-ctaitem.m--btn-link .cmp-ctaitem:active .cmp-ctaitem__icon{color:#262262}.cmp-p-ctaitem.m--btn-link .cmp-ctaitem__anchor{font-size:14px}.cmp-p-ctaitem.m--btn-link .cmp-ctaitem__icon{float:left;display:inline-block;padding-top:8px;margin-right:8px;color:#0071d0}.cmp-p-ctaitem.m--mini .cmp-ctaitem{height:30px;line-height:30px;padding:0 16px 0 16px}.cmp-p-ctaitem.m--mini .cmp-ctaitem__icon{margin-top:2px}.cmp-p-ctaitem.m--small .cmp-ctaitem{height:34px;line-height:34px;padding:0 16px 0 16px}.cmp-p-ctaitem.m--small .cmp-ctaitem__icon{margin-top:5px}.cmp-p-ctaitem.m--large .cmp-ctaitem{height:50px;line-height:50px;padding:0 24px 0 24px}.cmp-p-ctaitem.m--large .cmp-ctaitem__icon{margin-top:12px}.cmp-p-ctaitem.m--block .cmp-ctaitem{width:100%}.cmp-p-ctaitem.m--left-icon .cmp-ctaitem__icon{display:inline-block;float:left;width:24px;margin-right:10px;margin-left:0}.cmp-p-ctaitem.m--lc-cta .cmp-ctaitem{width:fit-content}.cmp-p-ctaitem.m--lc-cta .cmp-ctaitem__icon{left:0;float:right;margin-right:10px;margin-left:10px}.cmp-p-ctaitem.m--lc-cta-left{margin-top:24px}.cmp-p-ctaitem.m--lc-cta-left .cmp-ctaitem__icon{float:left;margin-right:10px;margin-left:10px;transform:rotate(179deg)}@media (min-width:1200px){.cmp-p-ctaitem.m--sticky-lc{position:fixed;top:155px;max-width:245px}}.m-l1{margin:16px}.m-l2{margin:24px}.m-l3{margin:32px}.m-l4{margin:48px}.m-l5{margin:64px}.m-l0{margin:0!important}.mx-l1{margin:0 16px}.mx-l2{margin:0 24px}.mx-l3{margin:0 32px}.mx-l4{margin:0 48px}.mx-l5{margin:0 64px}.mx-l1{margin:16px 0}.mx-l2{margin:24px 0}.mx-l3{margin:32px 0}.mx-l4{margin:48px 0}.mx-l5{margin:64px 0}.mt-l1{margin-top:16px}.mt-l2{margin-top:24px}.mt-l3{margin-top:32px}.mt-l4{margin-top:48px}.mt-l5{margin-top:64px}.mb-l1{margin-bottom:16px}.mb-l2{margin-bottom:24px}.mb-l3{margin-bottom:32px}.mb-l4{margin-bottom:48px}.mb-l5{margin-bottom:64px}.ml-l1{margin-left:16px}.ml-l2{margin-left:24px}.ml-l3{margin-left:32px}.ml-l4{margin-left:48px}.ml-l5{margin-left:64px}.mr-l1{margin-right:16px}.mr-l2{margin-right:24px}.mr-l3{margin-right:32px}.mr-l4{margin-right:48px}.mr-l5{margin-right:64px}.p-l1{padding:16px}.p-l2{padding:24px}.p-l3{padding:32px}.p-l4{padding:48px}.p-l5{padding:64px}.p-l0{padding:0!important}.px-l1{padding:0 16px}.px-l2{padding:0 24px}.px-l3{padding:0 32px}.px-l4{padding:0 48px}.px-l5{padding:0 64px}.px-l1{padding:16px 0}.px-l2{padding:24px 0}.px-l3{padding:32px 0}.px-l4{padding:48px 0}.px-l5{padding:64px 0}.pt-l1{padding-top:16px}.pt-l2{padding-top:24px}.pt-l3{padding-top:32px}.pt-l4{padding-top:48px}.pt-l5{padding-top:64px}.pb-l1{padding-bottom:16px}.pb-l2{padding-bottom:24px}.pb-l3{padding-bottom:32px}.pb-l4{padding-bottom:48px}.pb-l5{padding-bottom:64px}.pl-l1{padding-left:16px}.pl-l2{padding-left:24px}.pl-l3{padding-left:32px}.pl-l4{padding-left:48px}.pl-l5{padding-left:64px}.pr-l1{padding-right:16px}.pr-l2{padding-right:24px}.pr-l3{padding-right:32px}.pr-l4{padding-right:48px}.pr-l5{padding-right:64px}.mt-s0{margin-top:0}.mt-s1{margin-top:2px}.mt-s2{margin-top:4px}.mt-s3{margin-top:8px}.mt-s4{margin-top:12px}.mt-s5{margin-top:16px}.mt-s6{margin-top:24px}.mt-s7{margin-top:32px}.mt-s8{margin-top:40px}.mt-s9{margin-top:48px}.mb-s0{margin-bottom:0}.mb-s1{margin-bottom:2px}.mb-s2{margin-bottom:4px}.mb-s3{margin-bottom:8px}.mb-s4{margin-bottom:12px}.mb-s5{margin-bottom:16px}.mb-s6{margin-bottom:24px}.mb-s7{margin-bottom:32px}.mb-s8{margin-bottom:40px}.mb-s9{margin-bottom:48px}.ml-s0{margin-left:0}.ml-s1{margin-left:2px}.ml-s2{margin-left:4px}.ml-s3{margin-left:8px}.ml-s4{margin-left:12px}.ml-s5{margin-left:16px}.ml-s6{margin-left:24px}.ml-s7{margin-left:32px}.ml-s8{margin-left:40px}.ml-s9{margin-left:48px}.mr-s0{margin-right:0}.mr-s1{margin-right:2px}.mr-s2{margin-right:4px}.mr-s3{margin-right:8px}.mr-s4{margin-right:12px}.mr-s5{margin-right:16px}.mr-s6{margin-right:24px}.mr-s7{margin-right:32px}.mr-s8{margin-right:40px}.mr-s9{margin-right:48px}.pt-s0{padding-top:0}.pt-s1{padding-top:2px}.pt-s2{padding-top:4px}.pt-s3{padding-top:8px}.pt-s4{padding-top:12px}.pt-s5{padding-top:16px}.pt-s6{padding-top:24px}.pt-s7{padding-top:32px}.pt-s8{padding-top:40px}.pt-s9{padding-top:48px}.pb-s0{padding-bottom:0}.pb-s1{padding-bottom:2px}.pb-s2{padding-bottom:4px}.pb-s3{padding-bottom:8px}.pb-s4{padding-bottom:12px}.pb-s5{padding-bottom:16px}.pb-s6{padding-bottom:24px}.pb-s7{padding-bottom:32px}.pb-s8{padding-bottom:40px}.pb-s9{padding-bottom:48px}.pl-s0{padding-left:0}.pl-s1{padding-left:2px}.pl-s2{padding-left:4px}.pl-s3{padding-left:8px}.pl-s4{padding-left:12px}.pl-s5{padding-left:16px}.pl-s6{padding-left:24px}.pl-s7{padding-left:32px}.pl-s8{padding-left:40px}.pl-s9{padding-left:48px}.pr-s0{padding-right:0}.pr-s1{padding-right:2px}.pr-s2{padding-right:4px}.pr-s3{padding-right:8px}.pr-s4{padding-right:12px}.pr-s5{padding-right:16px}.pr-s6{padding-right:24px}.pr-s7{padding-right:32px}.pr-s8{padding-right:40px}.pr-s9{padding-right:48px}.search{position:relative;padding:0;background:#f3f3f3}.search button,.search input{font-size:14px;margin-bottom:0;box-shadow:none}.search input{text-transform:none;letter-spacing:1px;background:0 0;border:1px solid #f3f3f3;padding:0 8px;width:190px;height:28px;line-height:28px;margin:0;outline:0;color:#333;position:relative;z-index:1;color:#333}.search input.selector-input-adjust{width:190px}.search input.suggested{color:#c9c8c8}.search input::-ms-clear{display:none;width:0;height:0}.search .search-button{background:0 0;border:none;float:right;height:30px;margin:0;text-align:center;padding:0;width:40px;filter:none;outline:0!important;border-bottom:4px solid transparent}.search .search-button span{display:inline-block;vertical-align:middle;background:url(../images/white/icons-utility.png);width:22px;height:26px;background-position:-4px -267px;text-indent:-9999px}.search .search-button.active{border-color:#ee3134}.search form.active input{width:330px}.search form.active input.selector-input-adjust{width:190px}.search form .searchAutoCompleteProviderSelector{position:relative;top:1px;width:160px;height:28px;background-color:#c9c8c8;border-radius:0;border:0;outline:1px solid #d8d8d8;margin:0;float:left}.search form .searchAutoCompleteProviderSelector:focus optgroup,.search form .searchAutoCompleteProviderSelector:focus option{background-color:#fff}.search form .searchAutoCompleteProviderSelector optgroup,.search form .searchAutoCompleteProviderSelector option{background-color:#e5e5e5}.search form.providers-enabled input{width:190px}.search li,.search ul{margin:0}.clearable{display:inline-block;position:absolute;cursor:pointer;right:.85rem;top:.85rem;font-size:1.2rem;z-index:54;width:18px;height:28px}.searchRemoveHide{display:none!important}div.search{padding:0}#search-mobile-button{display:none;position:fixed;left:35px;margin-top:-32px}#header-typeahead-suggested{display:none;color:#aaa;-webkit-text-fill-color:#aaa;position:absolute;top:0;right:1px;left:0;bottom:1px;background:0 0;z-index:0;width:100%}#header-typeahead-suggested.active{display:block}.ac_results{box-shadow:0 1px 2px rgba(0,0,0,.1);background:#fff;border:1px solid #d8d8d8;padding:10px;z-index:1;right:50px!important;top:34px!important}.ac_results li{color:#555;cursor:pointer;padding:2px 5px}.ac_results li.ac_over,.ac_results li:hover{background:#f8f8f8;color:#007ed5;cursor:pointer;text-decoration:none}.ac_results li.ac_skip,.ac_results li.ac_skip:hover{background:#fff;border-bottom:1px solid #d8d8d8;color:#1a2155;cursor:text;display:block;font-weight:700;padding:0 5px 5px 5px;margin-bottom:5px;text-decoration:none}.ac_results li.ac_skip em{font-style:normal}#header-typeahead{left:2px;z-index:500;overflow:hidden;width:663px;background:#fff;position:absolute;box-shadow:0 2px 2px rgba(0,0,0,.1);display:none;margin-top:2px;margin-left:-2px;outline:0}#header-typeahead a{cursor:pointer}#header-typeahead .typeahead-terms{float:left;width:70%;position:relative;z-index:508;overflow:hidden;font-size:12px}#header-typeahead .typeahead-group{background:#f7f7f7;border-radius:2px;padding:5px 20px!important}#header-typeahead .typeahead-span strong{font-weight:400;color:gray}#header-typeahead .typeahead-flyout{float:left;width:442px;height:300px;background:#f8f8f8;border-left:1px solid #d8d8d8;padding:10px;position:relative;left:-1px;z-index:501;overflow:hidden}#header-typeahead ul{list-style:none}#header-typeahead .typeahead-term-list li{display:block;line-height:22px;padding:5px 10px;width:100%!important}#header-typeahead .typeahead-term-list li.typeahead-ignore{padding:0;margin:0}#header-typeahead .typeahead-term-list li a{display:block;width:100%!important}#header-typeahead .typeahead-term-list li a.typeahead-term{display:inline-block;color:#333;text-overflow:ellipsis;overflow:hidden;white-space:nowrap;vertical-align:middle;border-bottom:2px solid transparent}#header-typeahead .typeahead-term-list li.highlighted{background:#ebf2fa!important}#header-typeahead span.typeahead-hr{display:block;border-bottom:1px solid #d8d8d8;margin-top:10px;margin-bottom:10px}#header-typeahead .typeahead-term-list a.typeahead-term.active span{border-bottom:0}#header-typeahead .typeahead-term-list a.typeahead-term.active span .title-text{border-bottom:0}#header-typeahead .title-text{color:#1e8ae7}#header-typeahead .search-suggestions{padding:10px;margin-bottom:5px;font-weight:700;cursor:default;background-color:#e5e5e5}.flyout-recent-searches,.flyout-typeahead{display:none}.flyout-recent-searches li{display:block;line-height:22px;padding:0 10px}.flyout-recent-searches li.term a{display:inline-block;color:#333;text-overflow:ellipsis;overflow:hidden;white-space:nowrap;border-bottom:2px solid transparent;width:100%!important}.flyout-recent-searches li.term a.active span{border-bottom:2px solid #ee3134}.flyout-recent-searches li.term a:hover{background-color:#ebf2fa}.flyout-recent-searches li.recent-searches{padding:10px;margin-bottom:5px;font-weight:700;cursor:default;background-color:#f9f9f9;font-weight:700}.flyout-recent-searches li.recent-searches em{font-style:normal}.flyout-search-shortcut .search-shortcut-list{border-top:1px solid #d8d8d8}.flyout-search-shortcut .search-shortcut-list li{display:block;line-height:22px;padding:0 10px}.flyout-search-shortcut .search-shortcut-list li.quickLinks a{display:inline-block;color:#1e8ae7;text-overflow:ellipsis;overflow:hidden;white-space:nowrap;border-bottom:2px solid transparent;width:100%!important}.flyout-search-shortcut_right{width:30%;float:right}.searchAutoCompleteProviderSelectorIE78{padding-top:4px;padding-bottom:3px;width:180px;height:30px;position:absolute;left:4px;top:4px;border:1px solid #d8d8d8;background-color:#e5e5e5;z-index:2}.searchAutoCompleteProviderSelectorIE78:focus{width:auto;background-color:#fff}.msie78Search{width:190px}.ie8 .header_row_1.layout_cont_middle{clear:both!important}.ie8 .header_row_2.layout_cont_middle{margin-left:285px!important}.ie8 #meganav-content{display:block!important}.ie8 .hide-meganav #meganav-content{display:none!important}@media (max-width:979px){.typeahead-group{padding:5px 30px!important}.general_search.layout_cont_middle{margin-right:0}.header_row_2.layout_cont_left{width:95%;float:none;margin:auto}.header_row_2.layout_cont_middle{width:95%;margin:auto}.header_row_2.layout_cont_left,.header_row_2.layout_cont_middle{padding:0 15px 0 15px!important}.layout_cont_right{float:none;width:100%}#mobile-search-button-container{float:right;width:50px;height:60px;border-left:1px solid #eee;border-right:1px solid #eee}#search-mobile-button{display:block;height:60px;width:50px;border:none;background:0 0;background-image:url(/etc/designs/lifetech/clientlibs/base/img/icon-search-black.svg);background-repeat:no-repeat;background-position:center;position:relative;left:0;margin-top:0}#search-mobile-button.active{border-bottom:3px solid #ee3134;background-image:url(/etc/designs/lifetech/clientlibs/base/img/icon-cross-black.svg);background-repeat:no-repeat;background-size:18px 18px}#focusAreaSelector{width:100%!important;margin:auto}.container-modifier{padding:0!important}#search-main.in{display:block;overflow:auto;overflow-x:hidden;overflow-y:auto;position:fixed;z-index:200;bottom:0;top:61px;left:0;right:0;background:#fff}#search-main.in .searchHeading{display:block!important;padding:40px 0 24px 0;font-size:25.35px;color:#a2a2a2;text-align:center;font-weight:400}#search-main.in .searchHeading span{color:#333;font-weight:700}.global-commerce-bar .logo img{height:28px}.search form{background:#fff;height:auto;border:none!important;margin-top:0;margin:auto;width:100%}.search form input{box-sizing:border-box;line-height:40px;height:60px;width:100%!important;-webkit-appearance:none;-moz-appearance:none;appearance:none;border:1px solid #dcdcdc}.search form input.active input{height:60px!important}.search form input.selector-input-adjust{width:100%}.search form .search-button{display:none;position:absolute;top:273px;width:100%!important;height:46px;padding-top:0;color:#fff;line-height:46px;border-radius:3px 3px!important;margin:auto;left:0;right:0}.search form .search-button img{display:none}.search form .search-button .search-text{display:inline-block}.search form .searchAutoCompleteProviderSelector{top:0;width:100%!important;line-height:40px;height:40px;float:none}#header-typeahead-input-container{width:100%;height:60px;left:0;right:0;margin:auto;padding:16px 0 16px 0;background:#fff}#header-typeahead{width:100%;top:77px;margin:auto;left:0;right:0}}@media only screen and (max-device-width:320px){.global-commerce-bar{height:60px;position:fixed;top:0;left:0;width:100%;margin:0;background:#fff;z-index:80;font-size:14px;border-bottom:1px solid #eee}.global-commerce-bar .logo{margin:0 0 0 54px!important;text-align:left;padding:15px 0 15px 0}.global-commerce-bar .user-utility{padding:0;margin:0}#header-nav-container #header-nav-button{width:50px;padding-left:15px}.search form{height:60px}.search form .search-button{display:block;position:absolute;top:229px;height:46px;padding-top:0;color:#fff;line-height:46px;border-radius:4px;margin:auto}.search form .search-button img{display:none}.search form .search-button .search-text{display:inline-block}.search form .searchAutoCompleteProviderSelector{height:60px}#mobile-search-button-container,#search-mobile-button{width:40px}#search-main.in{min-height:568px}#search-main.in .searchHeading{padding:16px 0 13px 0}#search-main.in .searchHeading p{font-size:16.25px}}@media (max-width:767px){.search-button{display:none}.clearable{top:2.25rem;right:2.85rem}.typeahead-group{padding:5px 10px!important}}@media (max-width:979px){.search form.active input{height:60px!important}.clearable{top:2.25rem!important;right:2.85rem!important}}.search{padding:0;background:0 0}.search .largeSearchBar .loading-wheel-sm{margin:16px 16px}.search button,.search input{font-size:14px;margin-bottom:0;box-shadow:none}.search input{height:50px;width:100%;box-sizing:border-box;background:0 0;letter-spacing:0;font-size:13px;padding-left:22px;border:none;border-top:1px solid #d8d8d8;border-bottom:1px solid #d8d8d8;line-height:28px;margin:0;outline:0;position:relative;z-index:1;color:#000}.search input.selector-input-adjust{width:100%}.search input::-ms-clear{display:none}.search input:-moz-placeholder,.search input:-ms-input-placeholder,.search input::-moz-placeholder,.search input::-webkit-input-placeholder,.search input::placeholder{color:#a2a2a2}.search .search-button span{display:inline-block;vertical-align:middle}.search .search-button.active{border-color:#ee3134}.search form{margin:0}.search form .search-button{border-radius:0 3px 3px 0!important;margin:0;text-align:center;filter:none;outline:0!important;border:none;height:50px;width:100px;background:#4a4a4a}.search form .search-button .search-text{display:none}.search form.active input{height:100%}.search form.active input.selector-input-adjust{width:100%}.search form .searchAutoCompleteProviderSelector{position:relative;width:285px;height:50px;background-color:#f9f9f9;border:0;margin:0;line-height:normal}.search form .searchAutoCompleteProviderSelector:focus optgroup,.search form .searchAutoCompleteProviderSelector:focus option{background-color:#fff}.search form .searchAutoCompleteProviderSelector optgroup,.search form .searchAutoCompleteProviderSelector option{background-color:#e5e5e5}.search li,.search ul{margin:0}.clearable{background:transparent url(/search/searchbar/resources/images/icon_16_close_mono@1_5x.svg) no-repeat right -20px center}.clearable.x{background-position:right 20px center}.clearable.onX{cursor:pointer}.clearable::-ms-clear{display:none;width:0;height:0}div.search{padding:0}#header-typeahead-input-container{width:100%;height:50px}#header-typeahead{width:100%;z-index:500;background:#fff;position:absolute;box-shadow:0 2px 2px rgba(0,0,0,.1);display:none;margin-top:0;outline:0}#header-typeahead a{cursor:pointer}#header-typeahead .typeahead-terms{float:left;width:70%;position:relative;z-index:508;overflow-y:auto;overflow-x:hidden;max-height:510px;font-size:12px}#header-typeahead .typeahead-term-list li a.typeahead-term{font-weight:500}.searchAutoCompleteProviderSelectorIE78{width:203px;height:52px;background-color:#f9f9f9;border:solid 0 #cdcccc;position:relative;top:0;outline:1px solid #d8d8d8;margin:0;float:left;padding-top:4px;line-height:normal;z-index:2}.searchAutoCompleteProviderSelectorIE78:focus{width:auto;background-color:#fff}.search-btn-icon{width:28px;height:28px}.chosen-container{position:relative;display:inline-block;vertical-align:middle;font-size:14px;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none}.chosen-container *{-webkit-box-sizing:border-box;box-sizing:border-box}.chosen-container .chosen-drop{position:absolute;top:100%;z-index:1010;width:100%;border:1px solid #aaa;border-top:0;background:#fff;-webkit-box-shadow:0 4px 5px rgba(0,0,0,.15);box-shadow:0 4px 5px rgba(0,0,0,.15);clip:rect(0,0,0,0);-webkit-clip-path:inset(100% 100%);clip-path:inset(100% 100%)}.chosen-container a{cursor:pointer}.chosen-container .chosen-single .group-name{margin-right:4px;overflow:hidden;white-space:nowrap;text-overflow:ellipsis;font-weight:400;color:#999}.chosen-container .chosen-single .group-name:after{content:":";padding-left:2px;vertical-align:top}.chosen-container .search-choice .group-name{margin-right:4px;overflow:hidden;white-space:nowrap;text-overflow:ellipsis;font-weight:400;color:#999}.chosen-container .search-choice .group-name:after{content:":";padding-left:2px;vertical-align:top}.chosen-container .chosen-results{color:#444;position:relative;overflow-x:hidden;overflow-y:auto;margin:0 4px 4px 0;padding:0 0 0 4px;max-height:350px;-webkit-overflow-scrolling:touch}.chosen-container .chosen-results li{display:none;margin:0;padding:5px 6px;list-style:none;line-height:15px;word-wrap:break-word;-webkit-touch-callout:none}.chosen-container .chosen-results li em{font-style:normal;text-decoration:underline}.chosen-container .chosen-results li.active-result{display:list-item;cursor:pointer}.chosen-container .chosen-results li.disabled-result{display:list-item;color:#ccc;cursor:default}.chosen-container .chosen-results li.highlighted{background-color:#3875d7;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#3875d7),color-stop(90%,#2a62bc));background-image:linear-gradient(#3875d7 20%,#2a62bc 90%);color:#fff}.chosen-container .chosen-results li.no-results{color:#777;display:list-item;background:#f4f4f4}.chosen-container .chosen-results li.group-result{display:list-item;font-weight:700;cursor:default}.chosen-container .chosen-results li.group-option{padding-left:15px}.chosen-container.chosen-with-drop .chosen-drop{clip:auto;-webkit-clip-path:none;clip-path:none}.chosen-container-single .chosen-single{position:relative;display:block;overflow:hidden;padding:0 0 0 8px;height:25px;border:1px solid #aaa;border-radius:5px;background-color:#fff;background:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#fff),color-stop(50%,#f6f6f6),color-stop(52%,#eee),to(#f4f4f4));background:linear-gradient(#fff 20%,#f6f6f6 50%,#eee 52%,#f4f4f4 100%);background-clip:padding-box;-webkit-box-shadow:0 0 3px #fff inset,0 1px 1px rgba(0,0,0,.1);box-shadow:0 0 3px #fff inset,0 1px 1px rgba(0,0,0,.1);color:#444;text-decoration:none;white-space:nowrap;line-height:24px}.chosen-container-single .chosen-single span{display:block;overflow:hidden;margin-right:26px;text-overflow:ellipsis;white-space:nowrap}.chosen-container-single .chosen-single abbr{position:absolute;top:6px;right:26px;display:block;width:12px;height:12px;background:url(/search/searchbar/resources/images/chosen-sprite.png) -42px 1px no-repeat;font-size:1px}.chosen-container-single .chosen-single abbr:hover{background-position:-42px -10px}.chosen-container-single .chosen-single div{position:absolute;top:0;right:0;display:block;width:18px;height:100%}.chosen-container-single .chosen-single div b{display:block;width:100%;height:100%;background:url(/search/searchbar/resources/images/chosen-sprite.png) no-repeat 0 2px}.chosen-container-single .chosen-default{color:#999}.chosen-container-single .chosen-single-with-deselect span{margin-right:38px}.chosen-container-single .chosen-search{position:relative;z-index:1010;margin:0;padding:3px 4px;white-space:nowrap}.chosen-container-single .chosen-search input[type=text]{margin:1px 0;padding:4px 20px 4px 5px;width:100%;height:auto;outline:0;border:1px solid #aaa;background:url(/search/searchbar/resources/images/chosen-sprite.png) no-repeat 100% -20px;font-size:1em;font-family:sans-serif;line-height:normal;border-radius:0}.chosen-container-single .chosen-drop{margin-top:-1px;border-radius:0 0 4px 4px;background-clip:padding-box}.chosen-container-single.chosen-disabled .chosen-single abbr:hover{background-position:-42px -10px}.chosen-container-single.chosen-container-single-nosearch .chosen-search{position:absolute;clip:rect(0,0,0,0);-webkit-clip-path:inset(100% 100%);clip-path:inset(100% 100%)}.chosen-container-multi .chosen-choices{position:relative;overflow:hidden;margin:0;padding:0 5px;width:100%;height:auto;border:1px solid #aaa;background-color:#fff;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(1%,#eee),color-stop(15%,#fff));background-image:linear-gradient(#eee 1%,#fff 15%);cursor:text}.chosen-container-multi .chosen-choices li{float:left;list-style:none}.chosen-container-multi .chosen-choices li.search-field{margin:0;padding:0;white-space:nowrap}.chosen-container-multi .chosen-choices li.search-field input[type=text]{margin:1px 0;padding:0;height:25px;outline:0;border:0!important;background:0 0!important;-webkit-box-shadow:none;box-shadow:none;color:#999;font-size:100%;font-family:sans-serif;line-height:normal;border-radius:0;width:25px}.chosen-container-multi .chosen-choices li.search-choice{position:relative;margin:3px 5px 3px 0;padding:3px 20px 3px 5px;border:1px solid #aaa;max-width:100%;border-radius:3px;background-color:#eee;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#f4f4f4),color-stop(50%,#f0f0f0),color-stop(52%,#e8e8e8),to(#eee));background-image:linear-gradient(#f4f4f4 20%,#f0f0f0 50%,#e8e8e8 52%,#eee 100%);background-size:100% 19px;background-repeat:repeat-x;background-clip:padding-box;-webkit-box-shadow:0 0 2px #fff inset,0 1px 0 rgba(0,0,0,.05);box-shadow:0 0 2px #fff inset,0 1px 0 rgba(0,0,0,.05);color:#333;line-height:13px;cursor:default}.chosen-container-multi .chosen-choices li.search-choice span{word-wrap:break-word}.chosen-container-multi .chosen-choices li.search-choice .search-choice-close{position:absolute;top:4px;right:3px;display:block;width:12px;height:12px;background:url(/search/searchbar/resources/images/chosen-sprite.png) -42px 1px no-repeat;font-size:1px}.chosen-container-multi .chosen-choices li.search-choice .search-choice-close:hover{background-position:-42px -10px}.chosen-container-multi .chosen-choices li.search-choice-disabled{padding-right:5px;border:1px solid #ccc;background-color:#e4e4e4;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#f4f4f4),color-stop(50%,#f0f0f0),color-stop(52%,#e8e8e8),to(#eee));background-image:linear-gradient(#f4f4f4 20%,#f0f0f0 50%,#e8e8e8 52%,#eee 100%);color:#666}.chosen-container-multi .chosen-choices li.search-choice-focus{background:#d4d4d4}.chosen-container-multi .chosen-choices li.search-choice-focus .search-choice-close{background-position:-42px -10px}.chosen-container-multi .chosen-results{margin:0;padding:0}.chosen-container-multi .chosen-drop .result-selected{display:list-item;color:#ccc;cursor:default}.chosen-container-active .chosen-single{border:1px solid #5897fb;-webkit-box-shadow:0 0 5px rgba(0,0,0,.3);box-shadow:0 0 5px rgba(0,0,0,.3)}.chosen-container-active .chosen-choices{border:1px solid #5897fb;-webkit-box-shadow:0 0 5px rgba(0,0,0,.3);box-shadow:0 0 5px rgba(0,0,0,.3)}.chosen-container-active .chosen-choices li.search-field input[type=text]{color:#222!important}.chosen-container-active.chosen-with-drop .chosen-single{border:1px solid #aaa;border-bottom-right-radius:0;border-bottom-left-radius:0;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#eee),color-stop(80%,#fff));background-image:linear-gradient(#eee 20%,#fff 80%);-webkit-box-shadow:0 1px 0 #fff inset;box-shadow:0 1px 0 #fff inset}.chosen-container-active.chosen-with-drop .chosen-single div{border-left:none;background:0 0}.chosen-container-active.chosen-with-drop .chosen-single div b{background-position:-18px 2px}.chosen-disabled{opacity:.5!important;cursor:default}.chosen-disabled .chosen-single{cursor:default}.chosen-disabled .chosen-choices .search-choice .search-choice-close{cursor:default}.chosen-rtl{text-align:right}.chosen-rtl .chosen-single{overflow:visible;padding:0 8px 0 0}.chosen-rtl .chosen-single span{margin-right:0;margin-left:26px;direction:rtl}.chosen-rtl .chosen-single div{right:auto;left:3px}.chosen-rtl .chosen-single abbr{right:auto;left:26px}.chosen-rtl .chosen-single-with-deselect span{margin-left:38px}.chosen-rtl .chosen-choices li{float:right}.chosen-rtl .chosen-choices li.search-field input[type=text]{direction:rtl}.chosen-rtl .chosen-choices li.search-choice{margin:3px 5px 3px 0;padding:3px 5px 3px 19px}.chosen-rtl .chosen-choices li.search-choice .search-choice-close{right:auto;left:4px}.chosen-rtl .chosen-results li.group-option{padding-right:15px;padding-left:0}.chosen-rtl .chosen-search input[type=text]{padding:4px 5px 4px 20px;background:url(/search/searchbar/resources/resources/images/chosen-sprite.png) no-repeat -30px -20px;direction:rtl}.chosen-rtl.chosen-container-single .chosen-results{margin:0 0 4px 4px;padding:0 4px 0 0}.chosen-rtl.chosen-container-single .chosen-single div b{background-position:6px 2px}.chosen-rtl.chosen-container-active.chosen-with-drop .chosen-single div{border-right:none}.chosen-rtl.chosen-container-single.chosen-with-drop .chosen-single div b{background-position:-12px 2px}@media only screen and (-webkit-min-device-pixel-ratio:1.5){.chosen-container .chosen-results-scroll-down span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container .chosen-results-scroll-up span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-multi .chosen-choices .search-choice .search-choice-close{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single abbr{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single div b{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-rtl .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}}@media only screen and (min-resolution:144dpi){.chosen-container .chosen-results-scroll-down span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container .chosen-results-scroll-up span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-multi .chosen-choices .search-choice .search-choice-close{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single abbr{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single div b{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-rtl .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}}@media only screen and (min-resolution:1.5dppx){.chosen-container .chosen-results-scroll-down span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container .chosen-results-scroll-up span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-multi .chosen-choices .search-choice .search-choice-close{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single abbr{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single div b{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-rtl .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}}.chosen-container-single .chosen-single{height:50px!important;border-radius:0!important;border-radius:3px 0 0 3px!important;background-color:#f9f9f9!important;border:1px solid #d8d8d8!important;outline:0!important;background-image:none!important;padding:0 20px 0 16px;box-shadow:none!important}.chosen-container-single .chosen-single>span{line-height:50px}.chosen-container-single .chosen-single div{right:20px}.chosen-container-single .chosen-single div b{background:0 0!important;border-color:#222 transparent transparent transparent;border-style:solid;border-width:5px 4px 0 4px;height:0!important;left:50%;margin-left:-4px;margin-top:-2px;position:absolute;top:50%;width:0!important}.chosen-drop{border-top:1px solid #d8d8d8}.chosen-drop .chosen-results{margin:0!important;padding:0!important;border-top:1px solid #dcdcdc}.chosen-drop .chosen-results .active-result.result-selected,.chosen-drop .chosen-results .active-result.result-selected.highlighted{background-repeat:no-repeat;background-size:10% 100%;background-position:left;color:#fff!important;background-color:#007fff!important;background-image:none!important}.chosen-drop .chosen-results .group-result{border-top:1px solid #dcdcdc;color:#a2a2a2}.chosen-drop .chosen-results li.group-option{padding-left:1.5rem;color:#000;padding-top:5px;padding-bottom:5px;font-size:13px}.chosen-drop .chosen-results li.group-option.highlighted{color:#000!important;background:#ebf2fa!important}.chosen-drop .chosen-results .active-result.highlighted{color:#000!important;background:#ebf2fa!important}@media screen and (max-width:767px){.flyout-typeahead .typeahead-terms{width:100%}.flyout-typeahead .flyout-search-shortcut_right{width:100%;display:flex}.flyout-typeahead .flyout-search-shortcut_right ul{width:100%}.flyout-typeahead .flyout-search-shortcut_right ul .search-suggestions{font-size:100%;font-weight:500!important}}@media (min-width:768px) and (max-width:991px){#header-typeahead{height:calc(100vh - 412px)!important}.flyout-typeahead .typeahead-terms{width:70%!important;float:left!important;border-right:1px solid #e5e5e5}.flyout-typeahead .flyout-search-shortcut_right{width:30%;float:right;border-left:1px solid #e5e5e5}.flyout-typeahead .flyout-search-shortcut_right ul .search-suggestions{font-size:100%;font-weight:500!important}.flyout-typeahead .typeahead-terms .typeahead-term-list{border-bottom:unset!important}}@media (min-width:992px) and (max-width:1023px){.flyout-typeahead .typeahead-terms{width:100%}.flyout-typeahead .flyout-search-shortcut_right{width:100%;display:flex}.flyout-typeahead .flyout-search-shortcut_right ul{width:100%}#header-typeahead .search-shortcut-list{border:unset!important}.flyout-typeahead .flyout-search-shortcut_right ul .search-suggestions{font-size:100%;font-weight:500!important}}@media (min-width:1024px) and (max-width:2560px){.flyout-typeahead .typeahead-terms{width:70%!important;float:left!important;border-right:1px solid #e5e5e5}.flyout-typeahead .flyout-search-shortcut_right{width:30%;float:right;border-left:1px solid #e5e5e5}.flyout-typeahead .flyout-search-shortcut_right ul .search-suggestions{font-size:100%;font-weight:500!important}.flyout-typeahead .typeahead-terms .typeahead-term-list{border-bottom:unset!important}}.layout_cont_middle #autoComplete_list_1{padding-inline-start:0}.layout_cont_middle #autoComplete_list_1 li{list-style:none;cursor:default}.layout_cont_middle .typeahead-term-list-ul{width:100%;z-index:500;background:#fff;position:absolute;box-shadow:0 2px 2px rgba(0,0,0,.1);margin-top:0;outline:0;font-size:12px}.layout_cont_middle .typeahead-term-list-ul .typeahead-list-space{line-height:22px;padding:5px 20px!important;width:70%}.layout_cont_middle .typeahead-term-list-ul .typeahead-list-space:hover{background:#ebf2fa!important}.layout_cont_middle .typeahead-term-list-ul a.typeahead-term{display:inline-block;color:#333!important;text-overflow:ellipsis;overflow:hidden;white-space:nowrap;vertical-align:middle;border-bottom:2px solid transparent;font-weight:500;text-decoration:none!important;width:100%!important;cursor:pointer}.layout_cont_middle .typeahead-term-list-ul a.typeahead-term .typeahead-span mark{font-weight:400;color:gray;background-color:unset}.layout_cont_middle .typeahead-term-list-ul .product-title{font-family:HelveticaNeue,Helvetica,Arial,sans-serif;line-height:22px;padding:5px 20px!important;font-weight:500;cursor:default;background-color:#f7f7f7;font-size:12px;pointer-events:none;color:#1b1b1d;margin-bottom:5px}.layout_cont_middle .typeahead-term-list-ul .result-item-label{width:70%;font-family:HelveticaNeue,Helvetica,Arial,sans-serif}.layout_cont_middle .typeahead-term-list-ul .result-item-label a{padding:5px 20px!important;font-size:12px;font-weight:400}.layout_cont_middle .typeahead-term-list-ul .result-item-label a:hover{background:#ebf2fa!important;width:100%}.layout_cont_middle .typeahead-term-list-ul .search-shortcuts-list{border-top:1px solid #dcdcdc;cursor:pointer;font-size:14px;width:70%}.layout_cont_middle .typeahead-term-list-ul .search-shortcuts-list div{line-height:22px}.layout_cont_middle .typeahead-term-list-ul .search-shortcuts-list a.quickLinks{display:block;color:#0071d0;padding:10px 20px 6px;width:100%;cursor:pointer;text-decoration:none;font-weight:500}.layout_cont_middle .typeahead-term-list-ul .search-shortcuts-list .search-shortcuts-list-header{font-size:14px;line-height:18px;font-family:HelveticaNeue,Helvetica,Arial,sans-serif;padding:5px 20px;cursor:default;font-weight:500;line-height:22px;background:#f7f7f7;margin-bottom:5px}.layout_cont_middle .typeahead-term-list-ul .search-shortcut-list-no-data{border-top:1px solid #dcdcdc;cursor:pointer;font-size:14px;width:100%}.layout_cont_middle .typeahead-term-list-ul .search-shortcut-list-no-data div{line-height:22px}.layout_cont_middle .typeahead-term-list-ul .search-shortcut-list-no-data a.quickLinks{display:block;color:#0071d0;padding:10px 20px 6px;width:100%;cursor:pointer;text-decoration:none;font-weight:500}.layout_cont_middle .typeahead-term-list-ul .search-shortcut-list-no-data .recent-search-term{padding:5px 20px}.layout_cont_middle .typeahead-term-list-ul .search-shortcut-list-no-data .recent-search-term:hover{background-color:#ebf2fa}.layout_cont_middle .typeahead-term-list-ul .search-shortcut-list-no-data .recent-search-term a:hover{border-bottom:2px solid #ee3134}.layout_cont_middle .typeahead-term-list-ul .search-shortcut-list-no-data .search-shortcuts-list-header{font-size:14px;line-height:18px;font-family:HelveticaNeue,Helvetica,Arial,sans-serif;padding:5px 20px;cursor:default;font-weight:500;line-height:22px;background:#f7f7f7;margin-bottom:5px}.layout_cont_middle .typeahead-term-list-ul .typeahead__container__shortcuts_right{position:absolute;min-width:30%;width:fit-content;left:70%;height:100%;background:inherit;border:inherit;border-left:1px solid #e5e5e5;box-sizing:content-box;white-space:nowrap}.layout_cont_middle .search-suggestions{margin-bottom:5px;font-weight:700;cursor:default;background-color:#e5e5e5;font-size:12px}.layout_cont_middle .recent-search-shortcuts-list a.quickLinks{display:block;color:#1e8ae7;padding:10px 0 6px;width:100%;cursor:pointer;text-decoration:none}.layout_cont_middle #searchMagnifyMobile{z-index:1!important;position:absolute!important;right:0!important;top:0!important}.layout_cont_middle #generalSearchInput #clearable{height:22px!important;width:16px!important}.layout_cont_middle [hidden]{display:none!important}@media screen and (max-width:767px){.layout_cont_middle #autoComplete_list_1{padding-inline-start:0;overflow-y:scroll}.layout_cont_middle .typeahead-term-list-ul{width:100%}.layout_cont_middle .typeahead-term-list-ul .typeahead-list-space{width:100%}.layout_cont_middle .typeahead-term-list-ul .result-item-label{width:100%}.layout_cont_middle .typeahead-term-list-ul .search-shortcuts-list{width:100%}.layout_cont_middle .typeahead-term-list-ul .typeahead__container__shortcuts_right{width:100%;left:0;border-top:1px solid #e5e5e5}}@media (min-width:768px) and (max-width:991px){.layout_cont_middle #autoComplete_list_1{padding-inline-start:0;display:flex;flex-direction:column}}@media (min-width:992px) and (max-width:1023px){.layout_cont_middle #autoComplete_list_1{padding-inline-start:0}.layout_cont_middle .typeahead-term-list-ul .typeahead__container__shortcuts_right{width:100%;left:0;border-top:1px solid #e5e5e5}}@media (min-width:1024px) and (max-width:2560px){.layout_cont_middle #autoComplete_list_1{padding-inline-start:0;display:flex;flex-direction:column;min-height:143px}}header .search-container .close{position:absolute;right:36px;width:42px;height:42px;opacity:1;z-index:1001}header .search-container.open{position:inherit}header .search-container.open .close{display:inline-block}header input::-webkit-input-placeholder{font-weight:400;font-size:12px;color:#a2a2a2;text-overflow:ellipsis}#focusAreaSelector{width:auto}.search li,.search ul{margin:0}.search input{font-size:14px;box-shadow:none;height:50px;width:100%;box-sizing:border-box;background:0 0;border-top:1px solid #d8d8d8;border-bottom:1px solid #d8d8d8;border-left:1px solid #f3f3f3;border-right:1px solid #f3f3f3;line-height:28px;margin:0;outline:0;position:relative;z-index:1;text-transform:none;padding:0 48px 0 22px;color:#333}.search input::-ms-clear{display:none;width:0;height:0}.search input:-moz-placeholder,.search input:-ms-input-placeholder,.search input::-moz-placeholder,.search input::-webkit-input-placeholder,.search input::input-placeholder,.search input::placeholder{font-weight:400;font-size:14px;line-height:22px;color:#a2a2a2;text-overflow:ellipsis}.search input .selector-input-adjust{width:100%}.search input.suggested{color:#c9c8c8}.search .search-btn-icon{height:32px;width:32px;margin-top:4px}.search form{margin:0;position:relative;display:inherit}.search form input{height:50px}.search form.active input{height:50px}.search form.active input.selector-input-adjust{width:100%}.search form .searchAutoCompleteProviderSelector{position:relative;width:285px;height:50px;background-color:#f9f9f9;border:0;margin:0;line-height:normal;top:1px;border-radius:0;outline:1px solid #d8d8d8;float:left}.search form .searchAutoCompleteProviderSelector optgroup,.search form .searchAutoCompleteProviderSelector option{background-color:#e5e5e5}.search form .searchAutoCompleteProviderSelector:focus optgroup,.search form .searchAutoCompleteProviderSelector:focus option{background-color:#fff}.search form.providers-enabled input{width:100%}.search button,.search input{font-size:14px;margin-bottom:0;box-shadow:none}.global-commerce-bar{height:60px;position:fixed;top:0;left:0;width:100%;margin:0;background:#fff;z-index:80;font-size:14px;border-bottom:1px solid #eee}.global-commerce-bar .logo{margin:0 0 0 54px!important;text-align:left;padding:15px 0 15px 0}.global-commerce-bar .user-utility{padding:0;margin:0}.global-commerce-bar-spacing{height:0;border-bottom:none}#header-nav-container #header-nav-button{width:50px;padding-left:15px}#search-mobile-button{display:none;position:fixed;width:40px;left:35px;margin-top:-32px}#search-mobile-button-container{width:40px}#search-main.in{min-height:568px}#search-main.in .searchHeading{padding:16px 0 13px 0}#search-main.in .searchHeading p{font-size:16.25px}.clearable{position:absolute;cursor:pointer;top:32px;right:58px;width:16px;z-index:1}.clearable::-ms-clear{display:none;width:0;height:0}.clearable.x{background-position:right 20px center}.clearable.onX{cursor:pointer}.typeahead-group{padding:5px 10px!important}.chosen-container{position:relative;display:inline-block;vertical-align:middle;font-size:14px;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none}.chosen-container *{-webkit-box-sizing:border-box;box-sizing:border-box}.chosen-container .chosen-drop{position:absolute;top:100%;z-index:1010;width:100%;border:1px solid #aaa;border-top:0;background:#fff;-webkit-box-shadow:0 4px 5px rgba(0,0,0,.15);box-shadow:0 4px 5px rgba(0,0,0,.15);clip:rect(0,0,0,0);clip-path:inset(100% 100%);border-top:0}.chosen-container .chosen-with-drop .chosen-drop{clip:auto;clip-path:none}.chosen-container a{cursor:pointer}.chosen-container .chosen-single .group-name{margin-right:4px;overflow:hidden;white-space:nowrap;text-overflow:ellipsis;font-weight:400;color:#999}.chosen-container .chosen-single .group-name:after{content:":";padding-left:2px;vertical-align:top}.chosen-container .chosen-single.chosen-disabled .chosen-single abbr:hover{background-position:-42px -10px}.chosen-container .chosen-single.chosen-disabled-nosearch .chosen-search{position:absolute;clip:rect(0,0,0,0);clip-path:inset(100% 100%)}.chosen-container .search-choice .group-name{margin-right:4px;overflow:hidden;white-space:nowrap;text-overflow:ellipsis;font-weight:400;color:#999}.chosen-container .search-choice .group-name:after{content:":";padding-left:2px;vertical-align:top}.chosen-container .chosen-results{color:#444;position:relative;overflow-x:hidden;overflow-y:auto;margin:0 4px 4px 0;padding:0 0 0 4px;max-height:350px;-webkit-overflow-scrolling:touch}.chosen-container .chosen-results li{display:none;margin:0;padding:5px 6px;list-style:none;line-height:15px;word-wrap:break-word;-webkit-touch-callout:none}.chosen-container .chosen-results li em{font-style:normal;text-decoration:underline}.chosen-container .chosen-results li.active-result{display:list-item;cursor:pointer}.chosen-container .chosen-results li.disabled-result{display:list-item;color:#ccc;cursor:pointer}.chosen-container .chosen-results li.highlighted{background-color:#3875d7;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#3875d7),color-stop(90%,#2a62bc));background-image:linear-gradient(#3875d7 20%,#2a62bc 90%);color:#fff}.chosen-container .chosen-results li.no-results{color:#777;display:list-item;background:#f4f4f4}.chosen-container .chosen-results li.group-result{display:list-item;font-weight:700;cursor:default}.chosen-container .chosen-results li.group-option{padding-left:15px}.chosen-container.chosen-with-drop .chosen-drop{clip:auto;-webkit-clip-path:none;clip-path:none}.chosen-container-single .chosen-single{position:relative;display:block;overflow:hidden;text-decoration:none;white-space:nowrap;line-height:24px;height:50px;border-radius:3px 0 0 3px;background-color:#f9f9f9;border:1px solid #d8d8d8;outline:0;padding:0 20px 0 16px;box-shadow:none}.chosen-container-single .chosen-single span{display:block;overflow:hidden;margin-right:26px;text-overflow:ellipsis;white-space:nowrap}.chosen-container-single .chosen-single abbr{position:absolute;top:6px;right:26px;display:block;width:12px;height:12px;background:url(/search/searchbar/resources/images/chosen-sprite.png) -42px 1px no-repeat;font-size:1px}.chosen-container-single .chosen-single abbr:hover{background-position:-42px -10px}.chosen-container-single .chosen-single div{position:absolute;top:0;right:0;display:block;width:18px;height:100%;right:20px}.chosen-container-single .chosen-single div b{display:block;background:url(/search/searchbar/resources/images/chosen-sprite.png) no-repeat 0 2px;background:0 0!important;border-color:#222 transparent transparent transparent;border-style:solid;border-width:5px 4px 0 4px;height:0;left:50%;margin-left:-4px;margin-top:-2px;position:absolute;top:50%;width:0;background:0 0!important}.chosen-container-single .chosen-single>span{line-height:50px}.chosen-container-single .chosen-single-with-deselect span{margin-right:38px}.chosen-container-single .chosen-default{color:#999}.chosen-container-single .chosen-search{position:relative;z-index:1010;margin:0;padding:3px 4px;white-space:nowrap}.chosen-container-single .chosen-search input[type=text]{margin:1px 0;padding:4px 20px 4px 5px;width:100%;height:auto;outline:0;border:1px solid #aaa;background:url(/search/searchbar/resources/images/chosen-sprite.png) no-repeat 100% -20px;font-size:1em;font-family:sans-serif;line-height:normal;border-radius:0}.chosen-container-single .chosen-drop{margin-top:-1px;border-radius:0 0 4px 4px;background-clip:padding-box}.chosen-container-single .chosen-drop{margin-top:-1px;border-radius:0 0 4px 4px;background-clip:padding-box}.chosen-container-single.chosen-disabled .chosen-single abbr:hover{background-position:-42px -10px}.chosen-container-single.chosen-container-single-nosearch .chosen-search{position:absolute;clip:rect(0,0,0,0);-webkit-clip-path:inset(100% 100%);clip-path:inset(100% 100%)}.chosen-container-multi .chosen-choices{position:relative;overflow:hidden;margin:0;padding:0 5px;width:100%;height:auto;border:1px solid #aaa;background-color:#fff;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(1%,#eee),color-stop(15%,#fff));background-image:linear-gradient(#eee 1%,#fff 15%);cursor:text}.chosen-container-multi .chosen-choices li{float:left;list-style:none}.chosen-container-multi .chosen-choices li.search-field{margin:0;padding:0;white-space:nowrap}.chosen-container-multi .chosen-choices li.search-field input[type=text]{margin:1px 0;padding:0;height:25px;outline:0;border:0!important;background:0 0!important;-webkit-box-shadow:none;box-shadow:none;color:#999;font-size:100%;font-family:sans-serif;line-height:normal;border-radius:0;width:25px}.chosen-container-multi .chosen-choices li.search-choice{position:relative;margin:3px 5px 3px 0;padding:3px 20px 3px 5px;border:1px solid #aaa;max-width:100%;border-radius:3px;background-color:#eee;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#f4f4f4),color-stop(50%,#f0f0f0),color-stop(52%,#e8e8e8),to(#eee));background-image:linear-gradient(#f4f4f4 20%,#f0f0f0 50%,#e8e8e8 52%,#eee 100%);background-size:100% 19px;background-repeat:repeat-x;background-clip:padding-box;-webkit-box-shadow:0 0 2px #fff inset,0 1px 0 rgba(0,0,0,.05);box-shadow:0 0 2px #fff inset,0 1px 0 rgba(0,0,0,.05);color:#333;line-height:13px;cursor:default}.chosen-container-multi .chosen-choices li.search-choice span{word-wrap:break-word}.chosen-container-multi .chosen-choices li.search-choice .search-choice-close{position:absolute;top:4px;right:3px;display:block;width:12px;height:12px;background:url(/search/searchbar/resources/images/chosen-sprite.png) -42px 1px no-repeat;font-size:1px}.chosen-container-multi .chosen-choices li.search-choice .search-choice-close:hover{background-position:-42px -10px}.chosen-container-multi .chosen-choices li.search-choice-disabled{padding-right:5px;border:1px solid #ccc;background-color:#e4e4e4;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#f4f4f4),color-stop(50%,#f0f0f0),color-stop(52%,#e8e8e8),to(#eee));background-image:linear-gradient(#f4f4f4 20%,#f0f0f0 50%,#e8e8e8 52%,#eee 100%);color:#666}.chosen-container-multi .chosen-choices li.search-choice-focus{background:#d4d4d4}.chosen-container-multi .chosen-choices li.search-choice-focus .search-choice-close{background-position:-42px -10px}.chosen-container-multi .chosen-results{margin:0;padding:0}.chosen-container-multi .chosen-drop .result-selected{display:list-item;color:#ccc;cursor:default}.chosen-container-multi li .search-field{margin:0;padding:0;white-space:nowrap}.chosen-container-multi li .search-field input[type=text]{margin:1px 0;padding:0;height:25px;outline:0;border:0!important;background:0 0!important;-webkit-box-shadow:none;box-shadow:none;color:#999;font-size:100%;font-family:sans-serif;line-height:normal;border-radius:0;width:25px}.chosen-container-multi li.search-choice{position:relative;margin:3px 5px 3px 0;padding:3px 20px 3px 5px;border:1px solid #aaa;max-width:100%;border-radius:3px;background-color:#eee;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#f4f4f4),color-stop(50%,#f0f0f0),color-stop(52%,#e8e8e8),to(#eee));background-image:linear-gradient(#f4f4f4 20%,#f0f0f0 50%,#e8e8e8 52%,#eee 100%);background-size:100% 19px;background-repeat:repeat-x;background-clip:padding-box;-webkit-box-shadow:0 0 2px #fff inset,0 1px 0 rgba(0,0,0,.05);box-shadow:0 0 2px #fff inset,0 1px 0 rgba(0,0,0,.05);color:#333;line-height:13px;cursor:default}.chosen-container-multi li.search-choice span{word-wrap:break-word}.chosen-container-multi li.search-choice .search-choice-close{position:absolute;top:4px;right:3px;display:block;width:12px;height:12px;background:url(/search/searchbar/resources/images/chosen-sprite.png) -42px 1px no-repeat;font-size:1px}.chosen-container-multi li.search-choice .search-choice-close:hover{background-position:-42px -10px}.chosen-container-multi li.search-choice-disabled{padding-right:5px;border:1px solid #ccc;background-color:#e4e4e4;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#f4f4f4),color-stop(50%,#f0f0f0),color-stop(52%,#e8e8e8),to(#eee));background-image:linear-gradient(#f4f4f4 20%,#f0f0f0 50%,#e8e8e8 52%,#eee 100%);color:#666}.chosen-container-multi li.search-choice-focus{background:#d4d4d4}.chosen-container-multi li.search-choice-focus .search-choice-close{background-position:-42px -10px}.chosen-container-multi .chosen-results{margin:0;padding:0}.chosen-container-active .chosen-choices{border:1px solid #5897fb;-webkit-box-shadow:0 0 5px rgba(0,0,0,.3);box-shadow:0 0 5px rgba(0,0,0,.3)}.chosen-container-active .chosen-choices li.search-field input[type=text]{color:#222!important}.chosen-container-active .chosen-choices{border:1px solid #5897fb;-webkit-box-shadow:0 0 5px rgba(0,0,0,.3);box-shadow:0 0 5px rgba(0,0,0,.3)}.chosen-container-active .chosen-choices li.search-field input[type=text]{color:#222!important}.chosen-container-active.chosen-with-drop .chosen-single{border:1px solid #aaa;border-bottom-right-radius:0;border-bottom-left-radius:0;box-shadow:0 1px 0 #fff inset}.chosen-container-active.chosen-with-drop .chosen-single div{border-left:none;background:0 0}.chosen-container-active.chosen-with-drop .chosen-single div b{background-position:-18px 2px}.chosen-container-active.chosen-with-drop .chosen-single{border:1px solid #aaa;border-bottom-right-radius:0;border-bottom-left-radius:0;box-shadow:0 1px 0 #fff inset}.chosen-container-active.chosen-with-drop .chosen-single div{border-left:none;background:0 0}.chosen-container-active.chosen-with-drop .chosen-single div b{background-position:-18px 2px}.chosen-disabled{opacity:.5!important;cursor:default}.chosen-disabled .chosen-single{cursor:default}.chosen-disabled .chosen-choices .search-choice .search-choice-close{cursor:default}.chosen-rtl{text-align:right}.chosen-rtl .chosen-single{overflow:visible;padding:0 8px 0 0}.chosen-rtl .chosen-single span{margin-right:0;margin-left:26px;direction:rtl}.chosen-rtl .chosen-single div{right:auto;left:3px}.chosen-rtl .chosen-single abbr{right:auto;left:26px}.chosen-rtl .chosen-single-with-deselect span{margin-left:38px}.chosen-rtl .chosen-choices li{float:right}.chosen-rtl .chosen-choices li.search-choice{margin:3px 5px 3px 0;padding:3px 5px 3px 19px}.chosen-rtl .chosen-choices li.search-field input[type=text]{direction:rtl}.chosen-rtl .chosen-choices li.search-choice{margin:3px 5px 3px 0;padding:3px 5px 3px 19px}.chosen-rtl .chosen-choices li.search-choice .search-choice-close{right:auto;left:4px}.chosen-rtl .chosen-results li.group-option{padding-right:15px;padding-left:0}.chosen-rtl .chosen-search input[type=text]{padding:4px 5px 4px 20px;background:url(/search/searchbar/resources/resources/images/chosen-sprite.png) no-repeat -30px -20px;direction:rtl}.chosen-rtl.chosen-container-single .chosen-results{margin:0 0 4px 4px;padding:0 4px 0 0}.chosen-rtl.chosen-container-single .chosen-single div b{background-position:6px 2px}.chosen-rtl.chosen-container-active.chosen-with-drop .chosen-single div{border-right:none}.chosen-rtl.chosen-container-single.chosen-with-drop .chosen-single div b{background-position:-12px 2px}.chosen-drop{border-top:1px solid #d8d8d8}.chosen-drop .chosen-results{margin:0!important;padding:0!important;border-top:1px solid #dcdcdc}.chosen-drop .chosen-results .active-result.result-selected,.chosen-drop .chosen-results .active-result.result-selected.highlighted{background-repeat:no-repeat;background-size:10% 100%;background-position:left;color:#fff!important;background-color:#007fff!important;background-image:none!important}.chosen-drop .chosen-results .group-result{border-top:1px solid #dcdcdc;color:#a2a2a2}.chosen-drop .chosen-results li.group-option{padding-left:1.5rem;color:#000;padding-top:5px;padding-bottom:5px;font-size:13px}.chosen-drop .chosen-results li.group-option.highlighted{color:#000!important;background:#ebf2fa!important}.chosen-drop .chosen-results .active-result.highlighted{color:#000!important;background:#ebf2fa!important}.searchRemoveHide{display:none!important}.typeahead-span{margin-left:0!important}.typeahead-term-list{border-bottom:1px solid #dcdcdc}.header-typeahead{left:2px;z-index:500;overflow:hidden;position:absolute;box-shadow:0 2px 2px rgba(0,0,0,.1);display:none;margin-left:-2px;outline:0;width:100%;background:#fff;margin-top:0}.header-typeahead a{cursor:pointer}.header-typeahead .typeahead-terms{float:left;position:relative;z-index:508;overflow:hidden;font-size:12px;width:100%;overflow-y:auto;max-height:510px}.header-typeahead .typeahead-group{background:#f7f7f7;border-radius:2px;padding:5px 20px!important}.header-typeahead .typeahead-span{margin-left:0}.header-typeahead .typeahead-span strong{font-weight:400;color:gray}.header-typeahead .typeahead-flyout{float:left;width:442px;height:300px;background:#f8f8f8;border-left:1px solid #d8d8d8;padding:10px;position:relative;left:-1px;z-index:501;overflow:hidden}.header-typeahead ul{list-style:none}.header-typeahead .typeahead-term-list{border-bottom:1px solid #dcdcdc}.header-typeahead .typeahead-term-list li{display:block;line-height:22px;padding:5px 20px;width:100%!important}.header-typeahead .typeahead-term-list li a{display:block;width:100%!important}.header-typeahead .typeahead-term-list li a.typeahead-term{display:inline-block;color:#333;text-overflow:ellipsis;overflow:hidden;white-space:nowrap;vertical-align:middle;border-bottom:2px solid transparent;font-weight:500}.header-typeahead .typeahead-term-list li.typeahead-ignore{padding:0;margin:0}.header-typeahead .typeahead-term-list li.highlighted{background:#ebf2fa!important}.header-typeahead .typeahead-term-list a.typeahead-term.active span{border-bottom:0}.header-typeahead .typeahead-term-list a.typeahead-term.active span .title-text{border-bottom:0}.header-typeahead span.typeahead-hr{display:block;border-bottom:1px solid #d8d8d8;margin-top:10px;margin-bottom:10px}.header-typeahead .title-text{color:#0071d0}.header-typeahead .search-suggestions{padding:10px;margin-bottom:5px;font-weight:700;cursor:default;background-color:#e5e5e5}#header-typeahead{overflow-x:hidden;z-index:500;overflow-y:scroll;width:100%;background:#fff;position:absolute;box-shadow:0 2px 2px rgba(0,0,0,.1);display:none;outline:0;max-height:calc(100vh - 120px)}#header-typeahead a{cursor:pointer}#header-typeahead ul{list-style:none;padding-inline-start:0}#header-typeahead span.typeahead-hr{display:block;border-bottom:1px solid #d8d8d8;margin-top:10px;margin-bottom:10px}#header-typeahead .title-text{color:#0071d0}#header-typeahead .search-shortcut-list li a.quickLinks,#header-typeahead .typeahead-term-list li a.typeahead-term{display:inline-block;color:#333;text-overflow:ellipsis;overflow:hidden;white-space:nowrap;vertical-align:middle;border-bottom:2px solid transparent;font-weight:500}#header-typeahead .search-suggestions{padding:10px;margin-bottom:5px;font-weight:700;cursor:default;background-color:#e5e5e5}#header-typeahead .search-shortcut-list{border-top:1px solid #dcdcdc}#header-typeahead .search-shortcut-list li{display:block;line-height:22px;width:100%!important}#header-typeahead .search-shortcut-list li.highlighted{background:#ebf2fa!important}#header-typeahead .search-shortcut-list li.typeahead-ignore{padding:0;margin:0}#header-typeahead .search-shortcut-list li a{display:block;width:100%!important}#header-typeahead .search-shortcut-list li a.quickLinks{color:#0071d0;padding:10px 20px 6px}#header-typeahead .typeahead-terms{float:left;width:200px;position:relative;z-index:508;overflow:hidden;font-size:12px}#header-typeahead .typeahead-group{background:#f7f7f7;border-radius:2px;padding:5px 20px!important}#header-typeahead .typeahead-span strong{font-weight:400;color:gray}#header-typeahead .typeahead-flyout{float:left;width:442px;height:300px;background:#f8f8f8;border-left:1px solid #d8d8d8;padding:10px;position:relative;left:-1px;z-index:501;overflow:hidden}#header-typeahead .typeahead-term-list li{display:block;line-height:22px;padding:5px 20px;width:100%!important}#header-typeahead .typeahead-term-list li.highlighted{background:#ebf2fa!important}#header-typeahead .typeahead-term-list li.typeahead-ignore{padding:0;margin:0}#header-typeahead .typeahead-term-list li a{display:block;width:100%!important}#header-typeahead .typeahead-term-list li a.quickLinks{color:#0071d0}#header-typeahead .typeahead-term-list a.typeahead-term.active span{border-bottom:0}#header-typeahead .typeahead-term-list a.typeahead-term.active span .title-text{border-bottom:0}#header-typeahead-suggested{display:none;color:#aaa;-webkit-text-fill-color:#aaa;position:absolute;top:0;right:1px;left:0;bottom:1px;background:0 0;z-index:0;width:100%}#header-typeahead-suggested.active{display:block}#header-typeahead-input-container{width:100%;height:50px}.ac_results{box-shadow:0 1px 2px rgba(0,0,0,.1);background:#fff;border:1px solid #d8d8d8;padding:10px;z-index:1;right:50px!important;top:34px!important}.ac_results li{color:#555;cursor:pointer;padding:2px 5px}.ac_results li:hover{background:#f8f8f8;color:#007ed5;cursor:pointer;text-decoration:none}.ac_results li.ac_over{background:#f8f8f8;color:#007ed5;cursor:pointer;text-decoration:none}.ac_results li.ac_skip{background:#fff;border-bottom:1px solid #d8d8d8;color:#1a2155;cursor:text;display:block;font-weight:700;padding:0 5px 5px 5px;margin-bottom:5px;text-decoration:none}.ac_results li.ac_skip:hover{background:#fff;border-bottom:1px solid #d8d8d8;color:#1a2155;cursor:text;display:block;font-weight:700;padding:0 5px 5px 5px;margin-bottom:5px;text-decoration:none}.ac_results li.ac_skip em{font-style:normal}.flyout-recent-searches{display:none}.flyout-recent-searches li{display:block;line-height:22px;padding:0 20px}.flyout-recent-searches li.term a{display:inline-block;color:#333;text-overflow:ellipsis;overflow:hidden;white-space:nowrap;border-bottom:2px solid transparent;width:100%!important}.flyout-recent-searches li.term a:hover{background-color:#ebf2fa}.flyout-recent-searches li.recent-searches{padding:20px;margin-bottom:5px;cursor:default;background-color:#f9f9f9;font-weight:700}.flyout-recent-searches li.recent-searches em{font-style:normal}.flyout-typeahead{display:none}.searchAutoCompleteProviderSelectorIE78{width:203px;height:52px;background-color:#f9f9f9;border:solid 0 #cdcccc;outline:1px solid #d8d8d8;margin:0;float:left;padding-top:4px;line-height:normal;z-index:2;left:4px;padding-bottom:3px;position:absolute;top:4px}.searchAutoCompleteProviderSelectorIE78:focus{width:auto;background-color:#fff}.msie78Search{width:190px}.ie8 .header_row_1.layout_cont_middle{clear:both!important}.ie8 .header_row_2.layout_cont_middle{margin-left:285px!important}.ie8 #meganav-content{display:block!important}.ie8 .hide-meganav #meganav-content{display:none!important}@media only screen and (-webkit-min-device-pixel-ratio:1.5){.chosen-container .chosen-results-scroll-down span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container .chosen-results-scroll-up span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-multi .chosen-choices .search-choice .search-choice-close{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single abbr{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single div b{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-rtl .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}}@media only screen and (min-resolution:144dpi){.chosen-container .chosen-results-scroll-down span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container .chosen-results-scroll-up span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-multi .chosen-choices .search-choice .search-choice-close{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single abbr{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single div b{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-rtl .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}}@media only screen and (min-resolution:1.5dppx){.chosen-container .chosen-results-scroll-down span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container .chosen-results-scroll-up span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-multi .chosen-choices .search-choice .search-choice-close{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single abbr{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single div b{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-rtl .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}}@media (max-width:979px){.search form{background:#fff;height:auto;border:none!important;margin-top:0;margin:auto;width:100%}.search form input{box-sizing:border-box;line-height:40px;height:50px;width:100%!important;-webkit-appearance:none;-moz-appearance:none;appearance:none;border:1px solid #dcdcdc}.search form input.active input{height:50px}.search form input.selector-input-adjust{width:100%}.search form .search-button{display:none;position:absolute;top:273px;width:100%!important;height:46px;padding-top:0;color:#fff;line-height:46px;border-radius:3px 3px!important;margin:auto;left:0;right:0}.search form .search-button:hover{cursor:pointer}.search form .search-button img{display:none}.search form .search-btn-icon{right:14px;position:absolute;top:24px}.search form .searchAutoCompleteProviderSelector{top:0;width:100%!important;line-height:40px;height:40px;float:none}.search-container .search{display:none}.search-container.open .search{display:block;visibility:visible;opacity:1;position:fixed;z-index:1000;top:0;left:0;height:100%;width:100%;background-color:#fff;animation:fadeIn .5s}.container-modifier{padding:0!important}.typeahead-group{padding:5px 30px!important}.general_search.layout_cont_middle{margin-right:0}.header_row_2.layout_cont_left{width:95%;float:none;margin:auto;padding:0 15px 0 15px!important}.header_row_2.layout_cont_middle{width:95%;margin:auto;padding:0 15px 0 15px!important}.layout_cont_right{float:none;width:100%}#mobile-search-button-container{float:right;width:50px;height:60px;border-left:1px solid #eee;border-right:1px solid #eee}#search-mobile-button{display:block;height:60px;width:50px;border:none;background:0 0;background-image:url(/etc/designs/lifetech/clientlibs/base/img/icon-search-black.svg);background-repeat:no-repeat;background-position:center;position:relative;left:0;margin-top:0}#search-mobile-button.active{border-bottom:3px solid #ee3134;background-image:url(/etc/designs/lifetech/clientlibs/base/img/icon-cross-black.svg);background-repeat:no-repeat;background-size:18px 18px}#focusAreaSelector{width:100%!important;margin:auto}#search-main.in{display:block;overflow:auto;overflow-x:hidden;position:fixed;z-index:200;bottom:0;top:61px;left:0;right:0;background:#fff}#search-main.in .searchHeading{display:block!important;padding:40px 0 24px 0;font-size:25.35px;color:#a2a2a2;text-align:center;font-weight:400}#search-main.in .searchHeading span{color:#333;font-weight:700}.global-commerce-bar .logo img{height:28px}#header-typeahead-input-container{width:100%;height:60px;left:0;right:0;margin:auto;padding:16px 0 16px 0;background:#fff}#header-typeahead{height:calc(100vh - 280px);width:100%;top:66px;margin:auto;left:0;right:0}}@media (min-width:992px){.header_row_2.layout_cont_wrapper{display:flex;flex-direction:row}.header_row_2.layout_cont_left,.header_row_2.layout_cont_middle{min-width:200px;padding:0!important}.header_row_2.layout_cont_middle{margin-left:0;width:100%}.search form{display:flex;width:100%}.searchHeading{display:none}.searchMagnifyMobile{display:none}header .search-container .search .search-button .search-text{display:none}.clearable{top:15px;right:24px}}.searchHeading p{padding:72px 36px 24px;font-size:22px;font-weight:500;line-height:28px;color:#92929e}.searchHeading p span{color:#000}.general_search.layout_cont_middle{order:-1;width:100%;margin-right:0;position:relative}header .search-layout .close{z-index:1001}.gsh-global-search-form-container .type-ahead-ctnr .keyword-container .dropdown-menu.ng-hide{display:none}.gsh-global-search-form-container .tf-filter-condensed-ctnr .tf-filter-box{height:48px!important}header .gsh-global-search-form-container .tf-filter-condensed-ctnr .filter-drop-down-ctnr{min-width:210px;margin-top:0;width:100%}#header-offer-bar{height:0;display:none}body{margin-top:60px}body .main-top-spacing{margin-top:60px}body .search-bg{top:60px}body.hide-header{margin-top:0}body.hide-header header{display:none}body.has-messaging-bar{margin-top:106px}body.has-messaging-bar .main-top-spacing{margin-top:106px}body.has-messaging-bar .search-bg{top:106px}body.spectraviewer{margin-top:60px}body.bootstrap-noconflict{padding-top:10px}@media (min-width:576px){#header-offer-bar{height:35px;display:block}body{margin-top:96px}body .main-top-spacing{margin-top:96px}body .search-bg{top:96px}body.has-messaging-bar{margin-top:141px}body.has-messaging-bar .main-top-spacing{margin-top:141px}body.has-messaging-bar .search-bg{top:141px}}@media (min-width:992px){body{margin-top:112px}body .main-top-spacing{margin-top:112px}body .search-bg{top:112px}body.has-messaging-bar{margin-top:157px}body.has-messaging-bar .main-top-spacing{margin-top:157px}body.has-messaging-bar .search-bg{top:157px}body.spectraviewer{margin-top:76px}}.clear:after,.clear:before,.clearfix:after,.clearfix:before,.group:after,.group:before,.result:after,.result:before{display:table;content:"";line-height:0}.clear:after,.clearfix:after,.group:after,.result:after{clear:both}.hide-text{font:0/0 a;color:transparent;text-shadow:none;background-color:transparent;border:0}.input-block-level{-webkit-box-sizing:border-box;-moz-box-sizing:border-box;box-sizing:border-box;display:block;width:100%;min-height:36px}#promoBar .promo-bar-snippet{background:#f3f3f3;line-height:35px;height:35px;font-size:15px;text-align:center;vertical-align:middle;display:block}#promoBar .promo-bar-snippet strong{color:#ee3134}#promoBar .promo-bar-snippet em{font-style:inherit;color:#c8c8c8;font-family:Arial,sans-serif;font-size:28px;vertical-align:bottom}#promoBar a.promo-bar-snippet{color:#000}#promoBar a.promo-bar-snippet:hover{color:#fff;background:#c8c8c8}#promoBar a.promo-bar-snippet:hover a,#promoBar a.promo-bar-snippet:hover em,#promoBar a.promo-bar-snippet:hover strong{color:#fff}#promoBar .promo-bar-snippet{overflow-x:auto;overflow-y:hidden;white-space:nowrap;padding:0 10px}#promoBar .promo-bar-snippet #promoBarContainer{padding:0 10px}#promoBar .promo-bar-snippet::-webkit-scrollbar{display:none}@media (max-width:767px){#promoBar .promo-bar-snippet{margin:0 -10px}}@media (max-width:479px){#promoBar{display:none!important}}#landscapeBanner{position:fixed;bottom:0;width:100%;z-index:9999}#landscapeBanner.author{position:relative;bottom:unset}#landscapeBanner #landscapeBannerContainer{background:#f3f3f3;border:1px solid #dcdcdc;height:60px;display:block}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent{margin:auto}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-snippet{color:#222;font-size:22px;font-weight:500;line-height:60px;text-align:center;vertical-align:middle;display:block;font-family:HelveticaNeue,Helvetica,Roboto,"Segoe UI",Arial,sans-serif}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-snippet #lb-button{margin-left:30px;font-size:14px;margin-bottom:5px;border-radius:3px!important}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-snippet #lb-button.btn-lb-light-gray{color:#1e8ae7}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-snippet #lb-button.btn-lb-light-gray:hover{background-color:#fff;border:1px solid #1e8ae7}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-button{background:#f3f3f3;position:absolute;top:1px;right:40px;width:60px;height:62px;border:none}@media only screen and (max-width:979px) and (min-width:480px){#landscapeBanner{left:0}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent{margin-top:11px}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-snippet{overflow-wrap:break-word;margin-left:1rem;line-height:normal;font-size:18px;width:85%}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-snippet #lb-button{margin-left:20px}}@media only screen and (max-width:479px){#landscapeBanner{left:0}#landscapeBanner #landscapeBannerContainer{height:60px}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent{width:auto;margin-top:14px;margin-left:1rem}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-snippet{overflow-wrap:break-word;margin-left:.5rem;line-height:normal;font-size:14px;text-align:left;width:80%}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-snippet #lb-button{display:initial;padding:unset;border:none;background:unset;margin-left:8px}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-snippet #lb-button::after{content:"\203A"}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-button{right:1px;border:none}}@media only screen and (min-width:980px){#pdpOfferContainer{height:192px;border-style:solid;border-width:thin;border-color:#dcdcdc}#pdpOfferContainer.author{position:relative;bottom:unset}#pdpOfferContainer #pdpOffer-Content #pdp-image{width:164px;height:132px;padding:5px 5px 8px 7px;float:right}#pdpOfferContainer button{width:auto;height:30px;white-space:nowrap;border-radius:3px;background-color:#555759;font-family:"Helvetica Neue",Helvetica,Roboto,"Segoe UI",Arial,sans-serif;font-size:11px;font-weight:700;font-style:normal;font-stretch:normal;line-height:normal;letter-spacing:normal;text-align:center;color:#fff;margin-left:13px;margin-bottom:24px;position:relative;margin-right:90%;text-decoration:none}#pdpOfferContainer .close{width:12px;height:22px;opacity:.5;color:#000;background-color:#fff;float:right;font-size:20px;font-weight:700;line-height:22px;margin-right:15px}}@media only screen and (min-width:480px) and (max-width:767px){#pdpOfferContainer{height:192px;border-style:solid;border-width:thin;border-color:#dcdcdc}#pdpOfferContainer.author{position:relative;bottom:unset}#pdpOfferContainer #pdpOffer-Content #pdp-image{width:164px;height:132px;padding:5px 5px 8px 7px;float:right}#pdpOfferContainer button{width:auto;height:30px;white-space:nowrap;border-radius:3px;background-color:#555759;font-family:"Helvetica Neue",Helvetica,Roboto,"Segoe UI",Arial,sans-serif;font-size:11px;font-weight:700;font-style:normal;font-stretch:normal;line-height:normal;letter-spacing:normal;text-align:center;color:#fff;margin-left:13px;margin-bottom:24px;position:relative;margin-right:90%;text-decoration:none}#pdpOfferContainer .close{width:12px;height:22px;opacity:.5;color:#000;background-color:#fff;float:right;font-size:20px;font-weight:700;line-height:22px;margin-right:15px}}@media only screen and (min-width:767px) and (max-width:979px){#pdpOfferContainer{height:192px;border-style:solid;border-width:thin;border-color:#dcdcdc}#pdpOfferContainer.author{position:relative;bottom:unset}#pdpOfferContainer #pdpOffer-Content #pdp-image{visibility:hidden;width:0;height:0;display:none}#pdpOfferContainer button{width:auto;height:30px;white-space:nowrap;border-radius:3px;background-color:#555759;font-family:"Helvetica Neue",Helvetica,Roboto,"Segoe UI",Arial,sans-serif;font-size:11px;font-weight:700;font-style:normal;font-stretch:normal;line-height:normal;letter-spacing:normal;text-align:center;color:#fff;margin-left:13px;margin-bottom:24px;position:relative;margin-right:90%;text-decoration:none}#pdpOfferContainer .close{width:12px;height:22px;opacity:.5;color:#000;background-color:#fff;float:right;font-size:20px;font-weight:700;line-height:22px;margin-right:15px}}@media only screen and (max-width:479px){#pdpOfferContainer{height:192px;border-style:solid;border-width:thin;border-color:#dcdcdc}#pdpOfferContainer.author{position:relative;bottom:unset}#pdpOfferContainer #pdpOffer-Content #pdp-image{visibility:hidden;width:0;height:0;display:none}#pdpOfferContainer button{width:auto;height:30px;white-space:nowrap;border-radius:3px;background-color:#555759;font-family:"Helvetica Neue",Helvetica,Roboto,"Segoe UI",Arial,sans-serif;font-size:11px;font-weight:700;font-style:normal;font-stretch:normal;line-height:normal;letter-spacing:normal;text-align:center;color:#fff;margin-left:13px;margin-bottom:24px;position:relative;margin-right:90%;text-decoration:none}#pdpOfferContainer .close{width:12px;height:22px;opacity:.5;color:#000;background-color:#fff;float:right;font-size:20px;font-weight:700;line-height:22px;margin-right:15px}}#searchOffer-container{background-color:#ebf2fa;padding:10px 10px 1px 10px;position:relative;margin-bottom:10px}#searchOffer-container.author{position:relative;bottom:unset}#searchOffer-container #searchOffer-title{display:inline-block;margin:0 0 8px 0;line-height:19px;font-family:"Helvetica Neue-Medium",Helvetica,Arial,sans-serif;text-decoration:none;font-size:16px;color:#1e8ae7}#searchOffer-container #searchOffer-title a:hover{color:#005daa}#searchOffer-container #search-subtitle{display:inline-block;font-family:"Helvetica Neue-Medium",Helvetica,Arial,sans-serif;font-size:14px;line-height:17px;margin-bottom:12px}.overlay-modal-body{max-width:950px;margin:0 auto;display:inline-block;padding-left:10px;display:none}@media only screen and (max-width:767px){#tf-cart-overlay-1 p#cart-text{padding-top:14px;padding-left:13px;float:left;text-align:left}#tf-cart-overlay-1 .chevroncont{margin-top:0;padding-top:0;float:left;padding-left:13px}.overlay-modal-body img{max-width:90%;height:auto}}@media only screen and (max-width:479px){#tf-cart-overlay-1{padding-right:10%}} /*# sourceMappingURL=header.min.css.map */ </style>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_1"); </script> <script type="text/javascript" src="/store/global-header-footer-static/tf/js/utilities.min.468bd07150dbbf.js" async></script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_2"); </script>  <script data-inline-file-name='globalFunctions.js' data-inline-site='tf'>/* Hash: 468bd07150dbbf Source: /tf/js/dist/globalFunctions.js */ function getCookie(key) { var result = ""; var cookies = document.cookie ? document.cookie.split('; ') : []; for (var i = 0, l = cookies.length; i < l; i++) { var parts = cookies[i].split('='); var name = decodeURIComponent(parts.shift()); var cookie = parts.join('='); // Prevent storing or parsing of a cookie that we couldn't decode. if ( cookie && key === name ) { // removes surrounding quotes if ( cookie.indexOf('"') === 0) { // This is a quoted cookie as according to RFC2068, unescape... cookie = cookie.slice(1, -1).replace(/\\"/g, '"').replace(/\\\\/g, '\\'); } // parse utf8 characters // cannot use decode_utf8 because it will escape the value try { cookie = decodeURIComponent(cookie); } catch (e){ } result = cookie; // we found it, don't bother looking at other cookies break; } } return result; }; var setCookie = function(name, value, numDays){ if ( !numDays ) numDays = 31; var expires = new Date(); expires.setTime(expires.getTime() + (1000 * 60 * 60 * 24 * numDays)); document.cookie = name+ '=' + escape(value) + '; path=/; expires=' + expires.toGMTString() + '; domain=.' + this.getMasterDomain() + ';'; }; /** * get the domain based on a set of rules */ var getMasterDomain = function () { // default the domain var masterDomain = 'thermofisher.com'; // check for alternate domain. Upon match, the match[1] = domain_name, match[2] = domain_suffix var regexMatch = document.location.hostname.match(/\.(thermofisher)\.(cn)/i); if (regexMatch !== null) { // add the parts of the match. (match[1] = domain_name) + (match[2] = domain_suffix) masterDomain = regexMatch[1] + '.' + regexMatch[2]; } return masterDomain; }; var decode_utf8 = function ( s ){ try { s= decodeURIComponent( escape( s ) ); } catch ( err ) {} return s; }; var isResponsive = function() { // Even if we have viewport tag, IE8 wont support. // This can go away.. eventually // Lazy IE8 check var isIE8 = window.attachEvent && !window.addEventListener; return !isIE8 && document.querySelectorAll('meta[name="viewport"]').length > 0; }; var getCurrentViewportSize = function() { var which = 'lg'; if ( isResponsive() ) { which = 'xl'; var breakpoints = { lg: 1200, md: 980, sm: 768, xs: 480 }; var width = window.innerWidth; for ( var w in breakpoints ) { if ( width < breakpoints[w] ) which = w; } } return which; }; function getQueryParam (param) { var index, key, value, hash; var hashes = window.location.href.slice(window.location.href.indexOf('?') + 1).split('&'); for (index = 0; index < hashes.length; index++) { hash = hashes[index].split('='); key = hash[0]; value = hash[1]; if (key.toUpperCase() === param.toUpperCase()) return value; } return ''; };</script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_3"); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_4"); </script>  <div id="header-offer-bar"> <div class="interactoffers"> <div class="dynamic-offer" id="tf-headerfooter-hb" data-placement-type="headerfooter" data-placement-code="hb" data-default-snippet=""> </div> </div> </div>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_5"); </script> <script type="text/javascript"> var globalProviderConfig = { countryCode:'sg', langCode:'en', focusAreaPath:'/etc/thermo/endeca/focusAreas/default.html', items: [ { "group": null, "id": "all-categories", "title": "Search All", "searchURL": "/search/results?query={keyword}&focusarea={focusAreaName}", "typeAheadURL": "/search/service/typeaheadSuggestions?query={keyword}", "include": null, "exclude": null, "activation": null }, { "group": null, "id": "trial-catalog", "title": "Aspire Free Products", "searchURL": "/store/aspire/trials/searchTerm/{keyword}", "typeAheadURL": "/search/loyalty/service/typeahead?keyword={keyword}", "include": null, "exclude": null, "activation": ".*\/store\/aspire\/trials.*|.*LoyaltyDashboardDisplay.*|.*\/store\/aspire.*|.*LoyaltyRewardsDisplay.*" }, { "group": "Popular Product Areas", "id": "taqman-assays", "title": "TaqMan Assays", "searchURL": "/order/genome-database/searchResults?productTypeSelect=taqman&keyword={keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=filter1%3A(\"TAQMAN\")", "include": null, "exclude": ".*persona.DocSupport.*", "activation": ".*\/genome-database\/.*productTypeSelect.taqman.keyword.*|.*\/genome-database\/.*taqman*" }, { "group": "Popular Product Areas", "id": "gene-exp-assays", "title": "Gene Expression", "searchURL": "/order/genome-database/?pearUXVerSuffix=pearUX2&elcanoForm=true#!/ge/assays/ge_all/?keyword={keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=filter1%3A(%22GE%22)", "include": ".*\/order\/genome.*|.*\/taqman-gene-expression\/product\/.*|.*\/taqman-gene-expression\/query\/.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/genome-database\/browse\/gene-expression\/.*|.*\/genome-database\/details\/gene-expression\/.*|.*\/genome-database\/.*ge_all.*|.*\/genome-database\/.*plate_all.*|.*\/taqman-gene-expression\/product\/.*|.*\/taqman-gene-expression\/query\/.*" }, { "group": "Popular Product Areas", "id": "microbe-abr-detection", "title": "Microbe & ABR Detection", "searchURL": "/order/genome-database/?pearUXVerSuffix=pearUX2&elcanoForm=true#!/taqman/?keyword={keyword}&productSearch=microbe", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=filter1%3A(%22MCRB%22)", "include": ".*\/order\/genome.*|.*\/microbe-detection\/taqman\/query\/.*|.*\/antibiotic-resistance\/taqman\/query\/.*|.*\/microbe-detection\/taqman\/target-list\/.*|.*\/home\/clinical\/clinical-genomics\/pathogen-detection-solutions.*", "exclude": ".*persona.DocSupport.*", "activation": null }, { "group": "Popular Product Areas", "id": "microbe-detection", "title": "Microbe Detection", "searchURL": "/microbe-detection/taqman/query/{keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=filter1%3A(%22MCRB%22)", "include": ".*\/microbe-detection\/taqman\/query\/.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/microbe-detection\/taqman\/query\/.*" }, { "group": "Popular Product Areas", "id": "antibiotic-resistance", "title": "Antibiotic Resistance", "searchURL": "/antibiotic-resistance/taqman/query/{keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=filter1%3A(%22MCRB%22)", "include": ".*\/antibiotic-resistance\/taqman\/query\/.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/antibiotic-resistance\/taqman\/query\/.*" }, { "group": "Popular Product Areas", "id": "crispr-guide-rna", "title": "CRISPR Guide RNA", "searchURL": "/crispr/invitrogen/query/{keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=filter1%3A(%22CRSPR%22)", "include": ".*\/crispr\/.*|.*\/geneart.crispr\/.*|.*\/genome.editing\/geneart.crispr\/crispr.libraries\/lentiarray.crispr.libraries\/lentiarray.grnas.*|.*\/genome.database\/browse\/trueguide\/.*|.*\/genome.database\/browse\/lentiviral.*|.*productTypeSelect.crspr.targetTypeSelect.crspr.lentiviral.*|.*productTypeSelect.crspr.targetTypeSelect.crspr.true.guide.sgrna.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/crispr\/.*|.*\/geneart.crispr\/.*|.*\/genome.editing\/geneart.crispr\/crispr.libraries\/lentiarray.crispr.libraries\/lentiarray.grnas.*|.*\/genome.editing\/geneart.crispr\/crispr.grna.*|.*\/genome.database\/browse\/trueguide\/.*|.*\/genome.database\/browse\/lentiviral.*|.*productTypeSelect.crspr.targetTypeSelect.crspr.lentiviral.*|.*productTypeSelect.crspr.targetTypeSelect.crspr.true.guide.sgrna.*" }, { "group": "Popular Product Areas", "id": "copy-number-variation", "title": "Copy Number Variation", "searchURL": "/order/genome-database/?pearUXVerSuffix=pearUX2&elcanoForm=true#!/cnv/assays/cnv_all/?keyword={keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=%E2%80%9C&filters=filter1%3A(%22CNV%22)%E2%80%9D", "include": ".*\/order\/genome.*|.*\/taqman-gene-expression\/product\/.*|.*\/taqman-gene-expression\/query\/.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/genome-database\/browse\/cnv\/.*|.*\/genome-database\/details\/cnv\/.*|.*\/genome-database\/.*cnv_all.*" }, { "group": "Popular Product Areas", "id": "mutation-detection", "title": "Mutation Detection", "searchURL": "/order/genome-database/?pearUXVerSuffix=pearUX2&elcanoForm=true#!/mutation/assays/mutation_castPCR/?keyword={keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=%E2%80%9C&filters=filter1%3A(%22CPCR%22)%E2%80%9D", "include": ".*\/order\/genome.*|.*\/taqman-gene-expression\/product\/.*|.*\/taqman-gene-expression\/query\/.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/genome-database\/browse\/mutation-detection\/.*|.*\/genome-database\/details\/DPCR\/.*|.*\/genome-database\/.*mutation_digitalPCR.*" }, { "group": "Popular Product Areas", "id": "mirna", "title": "miRNA", "searchURL": "/order/genome-database/?pearUXVerSuffix=pearUX2&elcanoForm=true#!/microrna/assays/microrna_mature/?keyword={keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=filters=filter1%3A(%22MIRNA%22)%E2%80%9D", "include": ".*\/order\/genome.*|.*\/taqman-gene-expression\/product\/.*|.*\/taqman-gene-expression\/query\/.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/genome-database\/.*microrna_mature.*|.*\/genome-database\/.*microrna_advanced.*|.*\/genome-database\/.*microrna_all.*" }, { "group": "Popular Product Areas", "id": "snp-genotyping", "title": "SNP Genotyping", "searchURL": "/order/genome-database/?pearUXVerSuffix=pearUX2&elcanoForm=true#!/genotyping/assays/genotyping_all/?keyword={keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=%E2%80%9C&filters=filter1%3A(%22GT%22)%E2%80%9D", "include": ".*\/order\/genome.*|.*\/taqman-gene-expression\/product\/.*|.*\/taqman-gene-expression\/query\/.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/genome-database\/browse\/genotyping\/.*|.*\/genome-database\/details\/genotyping\/.*|.*\/genome-database\/.*genotyping_all.*|.*\/genome-database\/.*productTypeSelect=genotyping.*" }, { "group": "Popular Product Areas", "id": "primary-antibodies", "title": "Primary Antibodies", "searchURL": "/antibody/primary/query/{keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=filter1%3A(%22PRANT%22)+AND+filter3%3A(%22Pri-Anti%22)", "include": null, "exclude": ".*persona.DocSupport.*", "activation": ".*\/home\/life-science\/antibodies.html|.*\/home\/life-science\/antibodies\/primary.*|.*\/home\/life-science\/antibodies\/invitrogen-antibody-validation.*|.*\/antibody\/primary.*|.*\/antibody\/product\/.*-.ntibody.*|.*\/home\/life-science\/cell-analysis\/flow-cytometry\/antibodies-for-flow-cytometry.*|.*\/home\/order\/antibodies-immunoassays.html|.*\/antibody\/sitemap\/Primary-Antibodies-.*|.*\/antibody\/target\/.*|.*\/antibody\/gene\/.*|.*\/home\/life-science\/protein-biology\/protein-assays-analysis\/western-blotting\/detect-proteins-western-blot\/western-blot-detection-reagents\/western-blot-antibodies.*|.*\/home\/life-science\/antibodies\/primary-antibodies\/control-antibodies\/loading-control-antibodies.*" }, { "group": "Popular Product Areas", "id": "secondary-antibodies", "title": "Secondary Antibodies", "searchURL": "/antibody/secondary/query/{keyword}", "typeAheadURL": null, "include": null, "exclude": ".*persona.DocSupport.*", "activation": ".*\/home\/life-science\/antibodies\/secondary.*|.*\/antibody\/secondary.*|.*\/antibody\/product\/.*-.econdary-.ntibody.*|.*\/antibody\/sitemap\/Secondary-Antibodies-.*" }, { "group": "Popular Product Areas", "id": "isotype-controls", "title": "Isotype Controls", "searchURL": "/antibody/control/query/{keyword}", "typeAheadURL": null, "include": ".*\/antibody\/.*|.*\/elisa\/product\/.*|\/order\/genome.*|.*-.ntibody.*|.*-.rotein.*|.*-.eptide.*|.*-.ontrol.*|.*\/home\/order\/antibodies-immunoassays.html|.*\/proteins\/.*|.*\/immunoassays\/.*|.*\/elisa\/product\/.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/home\/life-science\/antibodies\/primary-antibodies\/control-antibodies.*|.*\/antibody\/product\/.*-.ontrol\/.*|.*\/antibody\/control\/.*|.*\/antibody\/sitemap\/Control-Antibodies-.*" }, { "group": "Popular Product Areas", "id": "proteins-and-peptides", "title": "Proteins & Peptides", "searchURL": "/proteins/query/{keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=filter1%3A(%22PRANT%22)+AND+filter3%3A(%22Sec-Anti%22)", "include": ".*\/proteins\/.*|.*\/antibody\/.*|.*\/elisa\/product\/.*|.*\/order\/genome.*|.*-.ntibody.*|.*-.rotein.*|.*-.eptide.*|.*-.ontrol.*|.*\/home\/order\/antibodies-immunoassays.html|.*\/immunoassays\/.*|.*\/elisa\/product\/.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/proteins\/.*|.*\/query\/.*-.ecombinant-.rotein\/.*|.*\/proteins\/query\/.*-.ynthetic-.eptide\/.*|.*\/proteins\/query\/.*-.ative-.rotein\/.*" }, { "group": "Popular Product Areas", "id": "elisa-kits", "title": "ELISA Kits", "searchURL": "/immunoassays/elisa/query/{keyword}", "typeAheadURL": "/order/genome-database/typeAheadSearch?keyword={keyword}&productSubType=elisa", "include": null, "exclude": ".*persona.DocSupport.*", "activation": ".*\/home\/life-science\/antibodies\/immunoassays\/elisa-kits.*|.*\/elisa\/product\/.*|.*\/immunoassays\/elisa\/query\/.*|.*\/immunoassays\/elisa\/target\/.*|.*\/immunoassays\/target\/.*" }, { "group": null, "id": "all-documents-support", "title": "All Documents & Support", "searchURL": "/search/results?query={keyword}&persona=DocSupport", "typeAheadURL": "n/a", "include": null, "exclude": ".*persona.DocSupport.*", "activation": ".*\/search\/results.query.*persona.DocSupport.*" }, { "group": null, "id": "certificates", "title": "Certificates", "searchURL": "/search/results?query={keyword}&persona=DocSupport&refinementAction=true&filter=document.result_type_s%3ACertificates", "typeAheadURL": null, "include": null, "exclude": null, "activation": ".*4294837200.*|.*docTypes=COA.*|.*filter.document.result.type.*Certificates.*" }, { "group": null, "id": "sds", "title": "SDS", "searchURL": "/search/results?query={keyword}&persona=DocSupport&filter=document.result_type_s%3ASDS&refinementAction=true", "typeAheadURL": null, "include": null, "exclude": null, "activation": ".*4294837192.*|.*docTypes=SDS.*|.*filter.document.result.type.*SDS.*" }, { "group": null, "id": "manuals-and-protocols", "title": "Manuals & Protocols", "searchURL": "/search/results?query={keyword}&persona=DocSupport&refinementAction=true&filter=document.result_type_s%3AManuals%20%26%20Protocols", "typeAheadURL": null, "include": null, "exclude": null, "activation": ".*4294837203.*|.*docTypes.Manuals.*|.*filter.document.result.type.*Manuals.*Protocols.*" }, { "group": null, "id": "support-files", "title": "Support Files", "searchURL": "/search/results?query={keyword}&persona=DocSupport&refinementAction=true&filter=document.result_type_s%3ASupport%20Files", "typeAheadURL": null, "include": ".*persona.DocSupport.*", "exclude": null, "activation": ".*4294837196.*|.*docTypes.SupportFiles.*|.*filter.document.result.type.*Support.*Files.*" }, { "group": null, "id": "product-literature", "title": "Product Literature", "searchURL": "/search/results?query={keyword}&persona=DocSupport&refinementAction=true&filter=document.result_type_s%3AProduct%20Literature", "typeAheadURL": null, "include": ".*persona.DocSupport.*", "exclude": null, "activation": ".*4294837193.*|.*docTypes.Brochures.*|.*filter.document.result.type.*Product.*Literature.*" }, { "group": null, "id": "citations-and-references", "title": "Citations & References", "searchURL": "/search/results?query={keyword}&persona=DocSupport&refinementAction=true&filter=document.result_type_s%3ACitations%20%26%20References", "typeAheadURL": null, "include": ".*persona.DocSupport.*", "exclude": null, "activation": ".*4294845218.*|.*docTypes.Citations.*|.*filter.document.result.type.*Citations.*References.*" }, { "group": null, "id": "product-faqs", "title": "Product FAQs", "searchURL": "/search/results?query={keyword}&persona=DocSupport&refinementAction=true&filter=document.result_type_s%3AProduct%20FAQs", "typeAheadURL": null, "include": null, "exclude": null, "activation": ".*4294837268.*|.*docTypes.FAQ.*|.*filter.document.result.type.*Product.*FAQs.*" }, { "group": null, "id": "ordering-and-web-faqs", "title": "Ordering & Web FAQs", "searchURL": "/search/results?query={keyword}&persona=DocSupport&filter=document.result_type_s%3AOrdering%20%26%20Web%20FAQs&refinementAction=true", "typeAheadURL": null, "include": ".*persona.DocSupport.*", "exclude": null, "activation": ".*navId.4294837259.*|.*filter.document.result.type.*Ordering.*Web.*FAQs.*" }, { "group": null, "id": "media-formulations", "title": "Media Formulations", "searchURL": "/search/results?query={keyword}&persona=DocSupport&filter=document.result_type_s%3AMedia%20Formulations&refinementAction=true", "typeAheadURL": null, "include": ".*persona.DocSupport.*", "exclude": null, "activation": ".*4294837198.*|.*docTypes.MediaFormulation.*|.*filter.document.result.type.*Media.*Formulations.*" }, { "group": null, "id": "molecular-probes-handbook", "title": "Molecular Probes Handbook", "searchURL": "/search/results?query={keyword}&persona=DocSupport&refinementAction=true&filter=document.result_type_s%3AMolecular%20Probes%20Handbook", "typeAheadURL": null, "include": ".*persona.DocSupport.*", "exclude": null, "activation": ".*4294837201.*|.*docTypes.Probes.*Handbook.*|.*filter.document.result.type.*Molecular.*Probes.*Handbook.*" }, { "group": null, "id": "spectra-data", "title": "Spectra Data", "searchURL": "/search/results?query={keyword}&persona=DocSupport&filter=document.result_type_s%3ASpectra%20Data&refinementAction=true", "typeAheadURL": null, "include": ".*persona.DocSupport.*", "exclude": null, "activation": ".*4294837270.*|.*docTypes.Probes.*Spectra.*|.*filter.document.result.type.*Spectra.*Data.*" }, { "group": null, "id": "vector-data", "title": "Vector Data", "searchURL": "/search/results?query={keyword}&persona=DocSupport&refinementAction=true&filter=document.result_type_s%3AVector%20Data", "typeAheadURL": null, "include": ".*persona.DocSupport.*", "exclude": null, "activation": ".*4294837191.*|.*docTypes.Vectors.*|.*filter.document.result.type.*Vector.*Data.*" } ] }; </script> <div class="main-header-container">  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_6"); </script>  <div id="nav-container" class="nav-container pragma-toggle-component"> <span class="sr-only">Hamburger Menu Button</span> <div id="hamburger-btn" class="menu hamburger-btn pragma-toggle" data-toggle="#nav-container,#full-bg" data-toggle-classes="open" tabindex="0"> <span class="icon"></span> </div> <nav id="mega-nav" class="mega-nav"> <span class="close pragma-toggle" data-toggle="#nav-container,#full-bg" data-toggle-classes="open"></span>  <span class="logo"> <a rel="home" href="/sg/en/home.html" id="hfLifetechLogoLinkSideNav"> <svg id="Layer_1" data-name="Layer 1" aria-labelledby="logo-alt" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 485.52 223.55"> <title id="logo-alt">Thermo Fisher Scientific Logo</title> <defs> <style> .tf-logo-cls-1 { fill: #E71316; } .tf-logo-cls-2 { fill: #fff; } </style> </defs> <rect class="tf-logo-cls-1" width="485.52" height="223.55" /> <path class="tf-logo-cls-2" d="M108.27,83.11V76h-32v7.13h11v31h9.92v-31Zm123.5,31c-.26-2.53-.42-4.49-.42-5.81V95.46c0-5.33-3.91-8.65-9.08-8.65a10.21,10.21,0,0,0-8.82,4.69c-1.11-3-4.38-4.54-7.44-4.54-3.7,0-6.81,1.22-8.55,4.54l-.22-4h-9.07V114.1h9.39v-16c0-.84-.37-5.38,4-5.38,2.91,0,3.59,2.59,3.59,5.12V114.1h9.34v-16c0-.84-.37-5.38,4-5.38,2.91,0,3.6,2.59,3.6,5.12V114.1ZM186,95.35V87.28c-4.07,0-7.18,1.27-8.39,5.33l-.22-5.07H168c.21,2.17.21,5.07.21,6.82V114.1h9.4V102.48c0-4.38,1.26-7.07,6.44-7.17.63,0,1.26,0,1.95,0m62-8.54c-8.66,0-14.31,4.8-14.31,13.93,0,9.4,5.71,14.1,14.31,14.1s14.31-4.7,14.31-14.1c0-9.13-5.65-13.93-14.31-13.93m0,5.59c4,0,4.7,4.06,4.7,8.23,0,4.86-.85,8.66-4.7,8.66s-4.7-3.8-4.7-8.66c0-4.22.74-8.28,4.7-8.28ZM137.21,114.1a57.55,57.55,0,0,1-.37-5.81V95.46c0-5.33-4-8.65-9.13-8.65a11.12,11.12,0,0,0-4.44.84,9.58,9.58,0,0,0-3.38,2.69V76H110.5V114.1h9.39v-16c0-.84-.36-5.38,4-5.38,3,0,3.59,2.59,3.59,5.12V114.1Zm28.72-11.46c0-9.55-2.8-15.83-13.41-15.83-8.39,0-13.41,5.17-13.41,13.25,0,9.92,3.54,14.78,13.88,14.78a14.49,14.49,0,0,0,8.24-2.22,9.58,9.58,0,0,0,4.49-7.29h-8.87a4.15,4.15,0,0,1-4.49,4.07c-3.59,0-4.32-3.43-4.27-6.76Zm-9-5.12h-8.71c.21-2.8.84-5.65,4.32-5.8a3.49,3.49,0,0,1,3.33,1.84,7.36,7.36,0,0,1,1.06,4Z" /> <path class="tf-logo-cls-2" d="M409.29,94.88V86.81c-4.06-.06-7.18,1.26-8.39,5.33l-.21-4.6H391.3c.2,2.17.2,5.07.2,6.81v19.74h9.4V102.48c0-4.38,1.27-7.54,6.44-7.65.63,0,1.26,0,2,0m-48.87,19.21a54.56,54.56,0,0,1-.37-5.8V95.47c0-5.34-4-8.66-9.13-8.66a10.52,10.52,0,0,0-4.33.84,9.73,9.73,0,0,0-3.49,2.69V76h-9.39v38.11h9.39v-16c0-.84-.37-5.38,4-5.38,2.95,0,3.59,2.58,3.59,5.12v16.25Zm-29-7.91c0-4.12-2.16-6.12-5.17-7.23-5.65-2-9.88-2.11-9.88-4.23a2.24,2.24,0,0,1,2.44-2.48,3.34,3.34,0,0,1,2.52.85,3.7,3.7,0,0,1,.69,2.53h8.92c-.21-7-5.7-8.81-11.72-8.81-5.12,0-11.76,1.79-11.76,8.18,0,9.29,15,6.86,15,11.82,0,1.75-1.43,2.53-3.28,2.53a2.92,2.92,0,0,1-2.42-1.26,3.36,3.36,0,0,1-.58-2.59h-9c-.16,7.92,5.7,9.35,12.19,9.35,6.08,0,12-2.22,12-8.66m57.78-3.54c.06-9.55-2.79-15.83-13.41-15.83-8.39,0-13.41,5.17-13.41,13.25,0,9.92,3.54,14.78,13.89,14.78a14.56,14.56,0,0,0,8.23-2.22,9.52,9.52,0,0,0,4.49-7.29H380.1a4.14,4.14,0,0,1-4.48,4.07c-3.59,0-4.33-3.43-4.28-6.76Zm-9-5.12H371.5c.21-2.8.84-5.65,4.33-5.8a3.51,3.51,0,0,1,3.33,1.85,7.38,7.38,0,0,1,1,4Zm-75.39-10h-9.39V114.1h9.39ZM292.5,83l2.22-7H269.47v38.11h9.92v-15h8l2.21-7H279.39V83Zm12.32,0,2.23-7h-9.29l-2.22,7Z" /> <path class="tf-logo-cls-2" d="M162.45,125.26h3.44v21.61h-3.44Zm232,22c-7.21,0-12.59-4-12.59-11s6-11.42,12.81-11.42a13.4,13.4,0,0,1,6.78,1.9l-1.77,2.09a10.44,10.44,0,0,0-5-1.41,9,9,0,0,0-6.85,2.64,8.89,8.89,0,0,0-2.18,6.33,7.9,7.9,0,0,0,2.56,6.3c1.65,1.63,4.18,2.08,6.66,2.08a12.1,12.1,0,0,0,5.46-1.55l1.68,2a14.64,14.64,0,0,1-7.59,2m-36.24-22h3.44v21.61h-3.44Zm-77.92,2.58h-8.05v19h-3.36v-19h-8v-2.58h19.77ZM100.78,146.1a13.66,13.66,0,0,1-6.09,1.22A20.13,20.13,0,0,1,86,145.37l1.43-2.45a16.3,16.3,0,0,0,7.54,1.82,7.65,7.65,0,0,0,3.93-.88,3.14,3.14,0,0,0,1.9-2.79c0-1.81-1.39-2.93-4.73-3.71l-3.51-.82c-3.5-.82-5.7-3-5.7-5.56,0-3.68,3.62-6.29,8.78-6.29a16.39,16.39,0,0,1,8.29,2.06L102.33,129a13.46,13.46,0,0,0-6.55-1.73c-3.07,0-5.2,1.19-5.2,3.22,0,1.56,1.3,2.49,4.31,3.22l3.25.78a11.33,11.33,0,0,1,4.78,2.18,5.38,5.38,0,0,1,1.68,3.86,6.4,6.4,0,0,1-3.82,5.57m138.41.77-8.58-11.52c-1.61-2.16-4.33-6.38-4.33-6.38s.3,3.65.32,6.85l.09,11.05h-3.43V125.26h4.09L236,137c1.69,2.29,4,5.92,4,5.92s-.52-4-.54-6.84l-.08-10.85h3.4v21.61Zm59.2-21.61h3.45v21.61h-3.45Zm41,2.54H327.56v6.4h10v2.54h-10v10.13h-3.45V125.26h15.76ZM188.17,146.87V125.26H204.1l-.46,2.58h-12v6.44h10.24v2.58h-10.2v7.3h12.86v2.71Zm-52.36.37c-7.2,0-12.58-4-12.58-11s6-11.42,12.8-11.42a13.4,13.4,0,0,1,6.78,1.9l-1.76,2.09a10.44,10.44,0,0,0-5-1.41,9,9,0,0,0-6.86,2.64,8.89,8.89,0,0,0-2.18,6.33,7.9,7.9,0,0,0,2.57,6.3c1.65,1.63,4.17,2.08,6.65,2.08a12.1,12.1,0,0,0,5.46-1.55l1.68,2a14.59,14.59,0,0,1-7.59,2" /> </svg> </a> </span> <div class="account-dd"> <div class="account"> <div class="cmp-p-ctaitem m--btn-primary m--block"> <div class="cmp-ctaitem"> <a class="cmp-ctaitem__anchor" href="/auth/initiate"> <span class="cmp-ctaitem__text">Sign in</span> </a> </div> </div> <div class="create-account pt-l1 pb-l1 border-bottom">Don't have an account ? <a href="/auth/create-account">Create Account</a> </div> <div class="create-account"> </div> </div> </div> <ul id='primary-nav' class='main-nav' data-analytics-section='top'> <li id='primary-link-1' class='main-nav-item pragma-toggle' data-toggle='#primary-link-1,nav' data-toggle-classes='open' data-analytics-section='top' data-analytics-parent='Products' tabindex='0'> <span class='arrow'></span>Products <ul id='secondary-nav-1' class='sub-nav'> <li id='secondary-link-1-1' > <a href='/sg/en/home/life-science/antibodies.html' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Antibodies'> Antibodies </a> </li> <li id='secondary-link-1-2' > <a href='/search/browse/category/us/en/90217060' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Cell Culture Media'> Cell Culture Media </a> </li> <li id='secondary-link-1-3' > <a href='/sg/en/home/chemicals.html' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Chemicals'> Chemicals </a> </li> <li id='secondary-link-1-4' > <a href='/search/browse/category/us/en/90155038' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Western Blot Products'> Western Blot Products </a> </li> <li id='secondary-link-1-5' > <a href='/search/browse/category/us/en/90126197' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Chromatography Columns and Cartridges'> Chromatography Columns and Cartridges </a> </li> <li id='secondary-link-1-6' > <a href='/sg/en/home/life-science/lab-equipment.html' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Lab Equipment'> Lab Equipment </a> </li> <li id='secondary-link-1-7' > <a href='/sg/en/home/life-science/lab-plasticware-supplies.html' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Lab Plasticware and Supplies'> Lab Plasticware and Supplies </a> </li> <li id='secondary-link-1-8' > <a href='/search/browse/category/us/en/90111007' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Microplates'> Microplates </a> </li> <li id='secondary-link-1-9' > <a href='/sg/en/home/life-science/oligonucleotides-primers-probes-genes.html' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Oligos, Primers, Probes and Genes'> Oligos, Primers, Probes and Genes </a> </li> <li id='secondary-link-1-10' > <a href='/sg/en/home/life-science/pcr/real-time-pcr/real-time-pcr-assays.html' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='TaqMan Real-Time PCR Assays'> TaqMan Real-Time PCR Assays </a> </li> <li id='secondary-link-1-11' > <a href='/sg/en/home/sustainable-design' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Greener Products'> Greener Products </a> </li> <li> <span class='see-all'> <a href='/sg/en/home/order.html' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='See all product categories'> See all product categories <span class='right-arrow'></span> </a> </span> </li> </ul> </li> <li id='primary-link-2' class='main-nav-item pragma-toggle' data-toggle='#primary-link-2,nav' data-toggle-classes='open' data-analytics-section='top' data-analytics-parent='Applications' tabindex='0'> <span class='arrow'></span>Applications <ul id='secondary-nav-2' class='sub-nav'> <li id='secondary-link-2-1' > <a href='/sg/en/home/life-science/bioproduction.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Bioprocessing'> Bioprocessing </a> </li> <li id='secondary-link-2-2' > <a href='/sg/en/home/life-science/cell-culture.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Cell Culture and Transfection'> Cell Culture and Transfection </a> </li> <li id='secondary-link-2-3' > <a href='/content/lifetech/global/en/home/industrial/food-beverage.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Food and Beverage'> Food and Beverage </a> </li> <li id='secondary-link-2-4' > <a href='/content/lifetech/global/en/home/lab-solutions.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Lab Solutions'> Lab Solutions </a> </li> <li id='secondary-link-2-5' > <a href='/content/lifetech/global/en/home/industrial/pharma-biopharma.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Pharma and Biopharma'> Pharma and Biopharma </a> </li> <li id='secondary-link-2-6' > <a href='/content/lifetech/global/en/home/life-science/pcr/real-time-pcr.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Real-Time PCR'> Real-Time PCR </a> </li> <li id='secondary-link-2-7' > <a href='/sg/en/home/semiconductors.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Semiconductor Analysis'> Semiconductor Analysis </a> </li> <li id='secondary-link-2-8' > <a href='/content/lifetech/global/en/home/clinical.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Clinical and Diagnostics'> Clinical and Diagnostics </a> </li> <li id='secondary-link-2-9' > <a href='/sg/en/home/digital-solutions.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Digital Solutions'> Digital Solutions </a> </li> <li id='secondary-link-2-10' > <a href='/sg/en/home/industrial/spectroscopy-elemental-isotope-analysis.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Spectroscopy, Elemental and Isotope Analysis'> Spectroscopy, Elemental and Isotope Analysis </a> </li> <li> <span class='see-all'> <a href='/sg/en/home/applications-techniques.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='See all applications and techniques'> See all applications and techniques <span class='right-arrow'></span> </a> </span> </li> </ul> </li> <li id='primary-link-3' class='main-nav-item pragma-toggle' data-toggle='#primary-link-3,nav' data-toggle-classes='open' data-analytics-section='top' data-analytics-parent='Services' tabindex='0'> <span class='arrow'></span>Services <ul id='secondary-nav-3' class='sub-nav'> <li id='secondary-link-3-1' > <a href='/sg/en/home/products-and-services/services/crdmo.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='Integrated CDMO-CRO Services'> Integrated CDMO-CRO Services </a> </li> <li id='secondary-link-3-2' > <a href='/sg/en/home/brands/patheon.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='CDMO Services'> CDMO Services </a> </li> <li id='secondary-link-3-3' > <a href='https://www.ppd.com/' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='CRO Services'> CRO Services </a> </li> <li id='secondary-link-3-4' > <a href='/sg/en/home/products-and-services/services/custom-services.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='Custom Services'> Custom Services </a> </li> <li id='secondary-link-3-5' > <a href='/sg/en/home/products-and-services/services/enterprise-services.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='Enterprise Services'> Enterprise Services </a> </li> <li id='secondary-link-3-6' > <a href='/sg/en/home/products-and-services/services/financial-leasing-services.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='Financial and Leasing Services'> Financial and Leasing Services </a> </li> <li id='secondary-link-3-7' > <a href='/sg/en/home/products-and-services/services/instrument-qualification-services.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='Instrument Services'> Instrument Services </a> </li> <li id='secondary-link-3-8' > <a href='/sg/en/home/digital-solutions/lab-informatics.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='Lab Informatics'> Lab Informatics </a> </li> <li id='secondary-link-3-9' > <a href='/sg/en/home/about-us/partnering-licensing/oem-commercial-supply.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='OEM and Commercial Supply'> OEM and Commercial Supply </a> </li> <li id='secondary-link-3-10' > <a href='/sg/en/home/products-and-services/services/training-services.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='Training Services'> Training Services </a> </li> <li> <span class='see-all'> <a href='/sg/en/home/products-and-services/services.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='See all services'> See all services <span class='right-arrow'></span> </a> </span> </li> </ul> </li> <li id='primary-link-4' class='main-nav-item pragma-toggle' data-toggle='#primary-link-4,nav' data-toggle-classes='open' data-analytics-section='top' data-analytics-parent='Help and Support' tabindex='0'> <span class='arrow'></span>Help and Support <ul id='secondary-nav-4' class='sub-nav'> <li id='secondary-link-4-1' > <a href='/sg/en/home/support/how-to-register-for-account.html' data-analytics-section='top' data-analytics-parent='Help and Support' data-analytics-text='Order Help'> Order Help </a> </li> <li id='secondary-link-4-2' > <a href='/sg/en/home/digital-solutions.html' data-analytics-section='top' data-analytics-parent='Help and Support' data-analytics-text='Digital Solutions'> Digital Solutions </a> </li> <li id='secondary-link-4-3' > <a href='/sg/en/home/technical-resources/instrument-support.html' data-analytics-section='top' data-analytics-parent='Help and Support' data-analytics-text='Product Support'> Product Support </a> </li> <li id='secondary-link-4-4' > <a href='/sg/en/home/technical-resources/technical-reference-library.html' data-analytics-section='top' data-analytics-parent='Help and Support' data-analytics-text='Technical Information'> Technical Information </a> </li> <li id='secondary-link-4-5' > <a href='/sg/en/home/technical-resources/learning-centers.html' data-analytics-section='top' data-analytics-parent='Help and Support' data-analytics-text='Training and Education'> Training and Education </a> </li> <li> <span class='see-all'> <a href='/sg/en/home/support.html' data-analytics-section='top' data-analytics-parent='Help and Support' data-analytics-text='See all help and support topics'> See all help and support topics <span class='right-arrow'></span> </a> </span> </li> </ul> </li> <li id='primary-link-5' class='main-nav-item pragma-toggle' data-toggle='#primary-link-5,nav' data-toggle-classes='open' data-analytics-section='top' data-analytics-parent='Popular' tabindex='0'> <span class='arrow'></span>Popular <ul id='secondary-nav-5' class='sub-nav'> <li id='secondary-link-5-1' class='popular' > <a href='/sg/en/home/life-science/pcr/real-time-pcr/real-time-pcr-assays.html' data-analytics-section='top' data-analytics-parent='Popular' data-analytics-text='TaqMan Real-Time PCR Assays'> <div> <img src='/content/dam/LifeTech/global/home-page/2019/taqman-hr-meganav.jpg' class='popular-image' loading='lazy' alt='TaqMan Real-Time PCR Assays'/> </div> <div class='pl-12'>TaqMan Real-Time PCR Assays</div> </a> </li> <li id='secondary-link-5-2' class='popular' > <a href='/sg/en/home/life-science/antibodies.html' data-analytics-section='top' data-analytics-parent='Popular' data-analytics-text='Antibodies'> <div> <img src='/content/dam/LifeTech/global/promotions/meganav/2017/01-Jan/popular2-175x115.gif' class='popular-image' loading='lazy' alt='Antibodies'/> </div> <div class='pl-12'>Antibodies</div> </a> </li> <li id='secondary-link-5-3' class='popular' > <a href='/sg/en/home/life-science/oligonucleotides-primers-probes-genes' data-analytics-section='top' data-analytics-parent='Popular' data-analytics-text='Oligos, Primers & Probes'> <div> <img src='/content/dam/LifeTech/global/home-page/images/oligos-main-popular.jpg' class='popular-image' loading='lazy' alt='Oligos, Primers & Probes'/> </div> <div class='pl-12'>Oligos, Primers & Probes</div> </a> </li> <li id='secondary-link-5-4' class='popular' > <a href='/sg/en/home/life-science/cloning/gene-synthesis/geneart-gene-synthesis.html' data-analytics-section='top' data-analytics-parent='Popular' data-analytics-text='GeneArt Gene Synthesis'> <div> <img src='/content/dam/LifeTech/global/promotions/meganav/2017/01-Jan/popular4-175x115.jpg' class='popular-image' loading='lazy' alt='GeneArt Gene Synthesis'/> </div> <div class='pl-12'>GeneArt Gene Synthesis</div> </a> </li> <li id='secondary-link-5-5' class='popular' > <a href='/sg/en/home/life-science/cell-culture/cell-culture-plastics.html' data-analytics-section='top' data-analytics-parent='Popular' data-analytics-text='Cell Culture Plastics'> <div> <img src='/content/dam/LifeTech/global/promotions/meganav/2017/01-Jan/popular5-175x115.jpg' class='popular-image' loading='lazy' alt='Cell Culture Plastics'/> </div> <div class='pl-12'>Cell Culture Plastics</div> </a> </li> </ul> </li> </ul> <ul class='support'> <li id='support-links-1'> <a href='/sg/en/home/technical-resources/contact-us.html' data-analytics-section='top' data-analytics-parent='mega-nav' data-analytics-text='Contact Us'>Contact Us</a> </li> <li id='support-links-2'> <a href='/store/v2/quick-order' data-analytics-section='top' data-analytics-parent='mega-nav' data-analytics-text='Quick Order'>Quick Order</a> </li> <li id='support-links-3'> <a href='/store/orders/solu' data-analytics-section='top' data-analytics-parent='mega-nav' data-analytics-text='Order Status and Tracking'>Order Status and Tracking</a> </li> <li id='support-links-4'> <a href='/sg/en/home/support/documents-certificates.html' data-analytics-section='top' data-analytics-parent='mega-nav' data-analytics-text='Documents and Certificates'>Documents and Certificates</a> </li> </ul>  </nav>  <span class="logo"> <a rel="home" href="/sg/en/home.html" id="hfLifetechLogoLink"> <svg id="Layer_1" data-name="Layer 1" aria-labelledby="logo-alt" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 485.52 223.55"> <title id="logo-alt">Thermo Fisher Scientific Logo</title> <defs> <style> .tf-logo-cls-1 { fill: #E71316; } .tf-logo-cls-2 { fill: #fff; } </style> </defs> <rect class="tf-logo-cls-1" width="485.52" height="223.55" /> <path class="tf-logo-cls-2" d="M108.27,83.11V76h-32v7.13h11v31h9.92v-31Zm123.5,31c-.26-2.53-.42-4.49-.42-5.81V95.46c0-5.33-3.91-8.65-9.08-8.65a10.21,10.21,0,0,0-8.82,4.69c-1.11-3-4.38-4.54-7.44-4.54-3.7,0-6.81,1.22-8.55,4.54l-.22-4h-9.07V114.1h9.39v-16c0-.84-.37-5.38,4-5.38,2.91,0,3.59,2.59,3.59,5.12V114.1h9.34v-16c0-.84-.37-5.38,4-5.38,2.91,0,3.6,2.59,3.6,5.12V114.1ZM186,95.35V87.28c-4.07,0-7.18,1.27-8.39,5.33l-.22-5.07H168c.21,2.17.21,5.07.21,6.82V114.1h9.4V102.48c0-4.38,1.26-7.07,6.44-7.17.63,0,1.26,0,1.95,0m62-8.54c-8.66,0-14.31,4.8-14.31,13.93,0,9.4,5.71,14.1,14.31,14.1s14.31-4.7,14.31-14.1c0-9.13-5.65-13.93-14.31-13.93m0,5.59c4,0,4.7,4.06,4.7,8.23,0,4.86-.85,8.66-4.7,8.66s-4.7-3.8-4.7-8.66c0-4.22.74-8.28,4.7-8.28ZM137.21,114.1a57.55,57.55,0,0,1-.37-5.81V95.46c0-5.33-4-8.65-9.13-8.65a11.12,11.12,0,0,0-4.44.84,9.58,9.58,0,0,0-3.38,2.69V76H110.5V114.1h9.39v-16c0-.84-.36-5.38,4-5.38,3,0,3.59,2.59,3.59,5.12V114.1Zm28.72-11.46c0-9.55-2.8-15.83-13.41-15.83-8.39,0-13.41,5.17-13.41,13.25,0,9.92,3.54,14.78,13.88,14.78a14.49,14.49,0,0,0,8.24-2.22,9.58,9.58,0,0,0,4.49-7.29h-8.87a4.15,4.15,0,0,1-4.49,4.07c-3.59,0-4.32-3.43-4.27-6.76Zm-9-5.12h-8.71c.21-2.8.84-5.65,4.32-5.8a3.49,3.49,0,0,1,3.33,1.84,7.36,7.36,0,0,1,1.06,4Z" /> <path class="tf-logo-cls-2" d="M409.29,94.88V86.81c-4.06-.06-7.18,1.26-8.39,5.33l-.21-4.6H391.3c.2,2.17.2,5.07.2,6.81v19.74h9.4V102.48c0-4.38,1.27-7.54,6.44-7.65.63,0,1.26,0,2,0m-48.87,19.21a54.56,54.56,0,0,1-.37-5.8V95.47c0-5.34-4-8.66-9.13-8.66a10.52,10.52,0,0,0-4.33.84,9.73,9.73,0,0,0-3.49,2.69V76h-9.39v38.11h9.39v-16c0-.84-.37-5.38,4-5.38,2.95,0,3.59,2.58,3.59,5.12v16.25Zm-29-7.91c0-4.12-2.16-6.12-5.17-7.23-5.65-2-9.88-2.11-9.88-4.23a2.24,2.24,0,0,1,2.44-2.48,3.34,3.34,0,0,1,2.52.85,3.7,3.7,0,0,1,.69,2.53h8.92c-.21-7-5.7-8.81-11.72-8.81-5.12,0-11.76,1.79-11.76,8.18,0,9.29,15,6.86,15,11.82,0,1.75-1.43,2.53-3.28,2.53a2.92,2.92,0,0,1-2.42-1.26,3.36,3.36,0,0,1-.58-2.59h-9c-.16,7.92,5.7,9.35,12.19,9.35,6.08,0,12-2.22,12-8.66m57.78-3.54c.06-9.55-2.79-15.83-13.41-15.83-8.39,0-13.41,5.17-13.41,13.25,0,9.92,3.54,14.78,13.89,14.78a14.56,14.56,0,0,0,8.23-2.22,9.52,9.52,0,0,0,4.49-7.29H380.1a4.14,4.14,0,0,1-4.48,4.07c-3.59,0-4.33-3.43-4.28-6.76Zm-9-5.12H371.5c.21-2.8.84-5.65,4.33-5.8a3.51,3.51,0,0,1,3.33,1.85,7.38,7.38,0,0,1,1,4Zm-75.39-10h-9.39V114.1h9.39ZM292.5,83l2.22-7H269.47v38.11h9.92v-15h8l2.21-7H279.39V83Zm12.32,0,2.23-7h-9.29l-2.22,7Z" /> <path class="tf-logo-cls-2" d="M162.45,125.26h3.44v21.61h-3.44Zm232,22c-7.21,0-12.59-4-12.59-11s6-11.42,12.81-11.42a13.4,13.4,0,0,1,6.78,1.9l-1.77,2.09a10.44,10.44,0,0,0-5-1.41,9,9,0,0,0-6.85,2.64,8.89,8.89,0,0,0-2.18,6.33,7.9,7.9,0,0,0,2.56,6.3c1.65,1.63,4.18,2.08,6.66,2.08a12.1,12.1,0,0,0,5.46-1.55l1.68,2a14.64,14.64,0,0,1-7.59,2m-36.24-22h3.44v21.61h-3.44Zm-77.92,2.58h-8.05v19h-3.36v-19h-8v-2.58h19.77ZM100.78,146.1a13.66,13.66,0,0,1-6.09,1.22A20.13,20.13,0,0,1,86,145.37l1.43-2.45a16.3,16.3,0,0,0,7.54,1.82,7.65,7.65,0,0,0,3.93-.88,3.14,3.14,0,0,0,1.9-2.79c0-1.81-1.39-2.93-4.73-3.71l-3.51-.82c-3.5-.82-5.7-3-5.7-5.56,0-3.68,3.62-6.29,8.78-6.29a16.39,16.39,0,0,1,8.29,2.06L102.33,129a13.46,13.46,0,0,0-6.55-1.73c-3.07,0-5.2,1.19-5.2,3.22,0,1.56,1.3,2.49,4.31,3.22l3.25.78a11.33,11.33,0,0,1,4.78,2.18,5.38,5.38,0,0,1,1.68,3.86,6.4,6.4,0,0,1-3.82,5.57m138.41.77-8.58-11.52c-1.61-2.16-4.33-6.38-4.33-6.38s.3,3.65.32,6.85l.09,11.05h-3.43V125.26h4.09L236,137c1.69,2.29,4,5.92,4,5.92s-.52-4-.54-6.84l-.08-10.85h3.4v21.61Zm59.2-21.61h3.45v21.61h-3.45Zm41,2.54H327.56v6.4h10v2.54h-10v10.13h-3.45V125.26h15.76ZM188.17,146.87V125.26H204.1l-.46,2.58h-12v6.44h10.24v2.58h-10.2v7.3h12.86v2.71Zm-52.36.37c-7.2,0-12.58-4-12.58-11s6-11.42,12.8-11.42a13.4,13.4,0,0,1,6.78,1.9l-1.76,2.09a10.44,10.44,0,0,0-5-1.41,9,9,0,0,0-6.86,2.64,8.89,8.89,0,0,0-2.18,6.33,7.9,7.9,0,0,0,2.57,6.3c1.65,1.63,4.17,2.08,6.65,2.08a12.1,12.1,0,0,0,5.46-1.55l1.68,2a14.59,14.59,0,0,1-7.59,2" /> </svg> </a> </span> </div>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_7"); </script> <div class="search-container"> <div class="search-layout">  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_8"); </script> <script src="/search/static/resources/js/signals.min.js" async></script> <script> var translations = {}; if ("prod" === "qa1" || "prod" === "qa4") { useV2Script = true; if (getCookie('enableSsi') === 'false') { useV2Script = false; } } else { useV2Script = "true" === "true"; if (getCookie('enableSsi') === 'false') { useV2Script = false; } else if (getCookie('enableSsi') === 'true') { useV2Script = true; } } var host = ''; if ("false" === true || "false" === 'true') { host = "//www.thermofisher.com"; } var searchEndpoint = '' if (useV2Script) { searchEndpoint = host + "/search/searchbar/resources/js/searchbarv2.js"; } else { searchEndpoint = host + "/search/searchbar/resources/js/searchbar.min.js"; } var script = document.createElement('script'); script.setAttribute('src', searchEndpoint); script.setAttribute('async', ''); var searchLayout = document.getElementsByClassName('search-layout'); if (searchLayout.length > 0) { searchLayout[0].appendChild(script); } else { document.body.appendChild(script); } </script> <script> var translations = { search: "Search by catalog number, product name, keyword, application", searchAll: "Search All", searchButton: "Search", searchIn: "Search within ", recentSearch: "Recent searches", moreWaysToSearch: "More ways to search", }; </script> <div class="search"> <div class="largeSearchBar" id="search-main"> <div class="searchHeading"> <p>Search <span>Thermo Fisher Scientific</span> </p> </div> <div id="searchModalBody" class="header_row_2 layout_cont_wrapper"> <div class="header_row_2 layout_cont_left" tabindex="0"> <div id="focusAreaSelector"> <div class="chosen-container chosen-container-single chosen-container-single-nosearch" style="width: 100%;" title="" id="chosenselector_chosen"><a class="chosen-single" tabindex="-1"><span>Search All </span> <div><b></b></div> </a></div> </div> </div> <div class="header_row_2 layout_cont_right"> </div> <div class="header_row_2 layout_cont_middle"> <div id="generalSearch" class="general_search layout_cont_wrapper"> <form id="smartsearch" method="get" autocomplete="off"> <input type="hidden" value="1" name="resultPage"> <input type="hidden" value="15" name="resultsPerPage"> <div class="general_search layout_cont_left"> </div> <div class="general_search layout_cont_right"> <button id="searchButton" type="submit" class="search-button" formaction="/search/results" tabindex="-1"> <p class="search-text">Search</p> <svg class="search-btn-icon" role="img" version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" xml:space="preserve"><defs><style>.cls-1-white{fill:#FFFFFF;}</style></defs><title>Search button</title><g id="Layer_462" data-name="Layer 462"><path class="cls-1-white" d="M27.49,26.45l-6.34-6.34a9.71,9.71,0,0,0-.31-13.42,9.76,9.76,0,0,0-13.77,0A9.73,9.73,0,0,0,19.66,21.45l6.41,6.42ZM8.48,19A7.73,7.73,0,1,1,14,21.31,7.68,7.68,0,0,1,8.48,19Z"/></g></svg> </button> </div> <div class="general_search layout_cont_middle"> <div id="generalSearchInput"> <div id="header-typeahead-input-container"> <input type="text" class="data-hj-whitelist" id="suggest1" name="query" accesskey="s" value="" role="search" autocomplete="off" placeholder="Search by catalog number, product name, keyword, application" tabindex="0"> <input type="text" id="header-typeahead-suggested" autocomplete="off" /> </div> <i id="searchMagnifyMobile" class="searchMagnifyMobile"> <svg class="search-btn-icon" role="img" version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" xml:space="preserve"><defs><style>.cls-1-grey{fill:#70707A;}</style></defs><title>Search button</title><g id="Layer_462" data-name="Layer 462"><path class="cls-1-grey" d="M27.49,26.45l-6.34-6.34a9.71,9.71,0,0,0-.31-13.42,9.76,9.76,0,0,0-13.77,0A9.73,9.73,0,0,0,19.66,21.45l6.41,6.42ZM8.48,19A7.73,7.73,0,1,1,14,21.31,7.68,7.68,0,0,1,8.48,19Z"/></g></svg> </i> <i id="searchRemove" class="clearable searchRemoveHide"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 28 18"><defs><style>.cls-1-grey{fill:#54545C;}</style></defs><title>Close</title><g id="Layer_154" data-name="Layer 154"><path class="cls-1-grey" d="M9.40199 0L0.148438 8.82L9.40199 17.64H27.8147V0H9.40199ZM25.7164 15.64H10.2623L3.10706 8.82L10.2623 2H25.7164V15.64ZM12.0773 12.09L15.5081 8.82L12.0773 5.63L13.5567 4.22L16.9454 7.45L20.3342 4.22L21.824 5.63L18.4772 8.82L21.866 12.05L20.3762 13.47L16.9874 10.24L13.5986 13.47L12.0773 12.09Z"/></g></svg> </i> <div id="header-typeahead"> <input type="hidden" id="typeahead-autocomplete" name="autocomplete" /> <div> <ul class="flyout-recent-searches hide"></ul> </div> <div class="flyout-typeahead"> <div class="typeahead-terms"><ul class="typeahead-term-list"></ul></div> <div class="flyout-search-shortcut_right"> <ul class="search-shortcut-list"></ul> </div> </div> <div class="flyout-search-shortcut"> <ul class="search-shortcut-list"></ul> </div> </div> </div> </div> </form> </div> <span class="loading-wheel-sm hidden"></span> <div id="primarySearch"> </div> </div> <div class="clear"></div> </div> </div> <div class="global-commerce-bar-spacing"></div> </div> <input type="hidden" id="clientTranslations" value='{"search":"Search by catalog number, product name, keyword, application","searchAll":"Search All","searchButton":"Search","searchIn":"Search within ","recentSearch":"Recent searches","moreWaysToSearch":"More ways to search"}'/>  <script data-inline-file-name='searchbar.min.js' data-inline-site='tf'>/* Hash: 468bd07150dbbf Source: /tf/js/dist/searchbar.min.js */ window.searchbar={init:function(){performance.mark("enter_initSearchbar()");try{console.log("searchbar_init - attempting to initialize globalProviderConfig...");var e=window.globalProviderConfig;console.log("searchbar_init - globalProviderConfig: {\n\t focusAreaPath: "+e.focusAreaPath+",\n\t countryCode: "+e.countryCode+",\n\t langCode: "+e.langCode+",\n\t items: "+e.items.length+"\n}")}catch(e){console.error("ERROR: searchbar_init ",e)}try{console.info("searchbar_init - attempting to load translations..."),translations=JSON.parse(document.getElementById("clientTranslations").value),console.info("searchbar_init - translations load complete!")}catch(e){console.error("ERROR: searchbar_init ",e)}try{console.info("searchbar_init - attempting to load searchSelector..."),thermofisher.search.searchSelector.init(),console.info("searchbar_init - searchSelector load complete!")}catch(e){console.error("ERROR: searchbar_init ",e)}if(!1===useV2Script)try{console.info("searchbar_init - attempting to load searchFocusArea..."),thermofisher.search.searchFocusArea.init(),console.info("searchbar_init - searchFocusArea load complete!")}catch(e){console.error("ERROR: searchbar_init ",e)}try{console.info("searchbar_init - attempting to load searchProvider..."),thermofisher.search.searchProvider.init(),console.info("searchbar_init - searchProvider load complete!")}catch(e){console.error("ERROR: searchbar_init ",e)}try{console.info("searchbar_init - attempting to load SignalsStatic..."),thermofisher.search.SignalsStatic.init(),console.info("searchbar_init - SignalsStatic load complete!")}catch(e){console.error("ERROR: searchbar_init ",e)}console.info("searchbar_init - all loading complete!"),performance.mark("exit_initSearchbar()"),performance.mark("exit_initSearchBarAfterEvent()"),performance.measure("searchbar_init__initSearchBarAfterEvent()","enter_initSearchBarAfterEvent()","exit_initSearchBarAfterEvent()"),performance.measure("searchbar_init__initSearchbar()","enter_initSearchbar()","exit_initSearchbar()")}};</script> <script type="text/javascript"> var whenJqueryReadyInterval = null; // used to "break" the jquery check loop document.addEventListener('DOMContentLoaded', function initSearchBarAfterEvent() { // load searchbar resources after page finishes loading performance.mark('enter_initSearchBarAfterEvent()'); var whenJqueryReadyInterval = setInterval(function initSearchBarAfterJqueryLoad() { // load searchbar resources only after jQuery is ready // performance.mark('enter_initSearchBarAfterJqueryLoad()'); if (window.useV2Script) { console.log("[Searchbar]Using V2 Script"); if (!window.thermofisher || !window.thermofisher.search || !window.thermofisher.search.searchSelector || !window.thermofisher.search.searchProvider || !window.thermofisher.search.SignalsStatic){ return; } console.info('searchbar_init - Using v2 - no jQuery needed!'); window.searchbar.init(); clearInterval(whenJqueryReadyInterval); whenJqueryReadyInterval = null; } else { console.log("[Searchbar]Using jQuery"); if (window.jQuery && (!window.thermofisher || !window.thermofisher.search || !window.thermofisher.search.searchSelector || !window.thermofisher.search.searchProvider || !window.thermofisher.search.SignalsStatic || !window.thermofisher.search.searchFocusArea)){ return; } console.info('searchbar_init - jQuery loaded!'); window.searchbar.init(); clearInterval(whenJqueryReadyInterval); whenJqueryReadyInterval = null; } }, 100); }); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_9"); </script> </div> <span class="close" tabindex="0"></span> <span class="search-icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24"><path class="cls-1" d="M20.79,19.66l-4.58-4.58a7.53,7.53,0,1,0-1.49,1.34l4.66,4.66ZM6.54,14.11a5.56,5.56,0,1,1,3.93,1.62A5.52,5.52,0,0,1,6.54,14.11Z"/> </svg> </span> </div>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_10"); </script> <div class="info-container" id="commerce-bar"> <ul>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_11"); </script> <li id="order-status-1" class="order-status" data-util-index="1" data-analytics-text="Order Status"> <a class="user-utility-link cloud-button" href="/store/orders/solu">Order Status</a> </li>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_12"); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_13"); </script> <li id="quick-order" class="quick-order" data-util-index="4" data-analytics-text="Quick Order"> <a href="/store/v2/quick-order"> Quick Order </a> </li>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_14"); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_15"); </script> <li id="sign-in" class="account pragma-toggle-component" data-util-index="3" data-analytics-text="Sign in"> <span id="sign-in-toggle" class="down-caret-icon pragma-toggle" data-toggle="#sign-in,#full-bg" data-toggle-classes="open"> Sign in </span>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_16"); </script> <div class="account-dd"> <div class="account"> <div class="cmp-p-ctaitem m--btn-primary m--block"> <div class="cmp-ctaitem"> <a class="cmp-ctaitem__anchor" href="/auth/initiate"> <span class="cmp-ctaitem__text">Sign in</span> </a> </div> </div> <div class="create-account pt-l1 pb-l1 border-bottom">Don't have an account ? <a href="/auth/create-account">Create Account</a> </div> <div class="create-account"> <ul> <li class="loyalty-text"><a href="#"></a></li> <li class="points"><a href="#"></a></li> <li> <a href="/auth/initiate">Account</a> </li> <li> <a href="/store/orders/solu">Check Order Status</a> </li> <li> <a href="https://apps.thermofisher.com ">Connect: Lab, Data, Apps</a> </li> <li> <a href="/auth/initiate">Custom Products & Projects</a> </li> <li> <a href="/auth/initiate">Instrument Management</a> </li> </ul>  </div> </div> </div>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_17"); </script> </li>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_18"); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_19"); </script> <li class="cart" data-util-index="5"> <a class = "pragma-remote-request" id="cart-link" href ="javascript:void(0)" data-remote-url = "/store/v2/minicart" data-remote-container ="#cart-sidebar" data-remote-failure-url="/store/cart"> <span class="count"></span> <svg data-toggle="#cart-sidebar,#full-bg" data-toggle-classes="open" class="pragma-toggle pragma-toggle-component" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 32 32"> <path class="cls-1" d="M11,25.55A1.76,1.76,0,1,1,9.27,23.8,1.76,1.76,0,0,1,11,25.55ZM24.65,23.8a1.76,1.76,0,1,0,1.76,1.75A1.75,1.75,0,0,0,24.65,23.8Zm1.46-2L29.46,9.64H10.24l.61,2.16H26.63l-2.16,7.81H9.76L5.59,4.94h-4l.62,2.15H4L8.14,21.77Z"/> </svg> </a> </li> </ul>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_20"); </script> <div id="cart-sidebar" class="cart-dd pragma-toggle-component"> </div>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_21"); </script> </div>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_22"); </script>  <script data-inline-file-name='utilitybarbase.min.js' data-inline-site='tf'>/* Hash: 468bd07150dbbf Source: /tf/js/dist/utilitybarbase.min.js */ var utilitybarBase=function(e){return e.$utilityBar=document.getElementById("user-utility-bar"),e.$quickOrder=document.getElementById("hfBarQuickOrder"),e.$cloudLink=document.getElementById("hfCloud"),e.$accountDropdown=document.querySelectorAll("#hfGreetAnonymous,#hfGreetByName")[0],e.$partnerDashboard=document.querySelectorAll("#hfGreetDashboard")[0],e.$miniCart=document.getElementById("miniCartButton"),e.$viewNotifications=document.getElementById("notification-link"),e.$drawer1=document.getElementById("mobile-nav-drawer-1"),e.$drawer2=document.getElementById("mobile-nav-drawer-2"),e.Large=function(){e.$partnerDashboard&&e.$utilityBar.appendChild(e.$partnerDashboard),e.$cloudLink&&e.$utilityBar.appendChild(e.$cloudLink),e.$quickOrder&&e.$utilityBar.appendChild(e.$quickOrder),e.$miniCart&&e.$utilityBar.appendChild(e.$miniCart),e.$viewNotifications&&!document.documentMode&&e.$utilityBar.appendChild(e.$viewNotifications),e.$accountDropdown&&e.$utilityBar.appendChild(e.$accountDropdown)},e.Medium=function(){e.$accountDropdown&&e.$drawer2.appendChild(e.$accountDropdown),e.$partnerDashboard&&e.$drawer2.appendChild(e.$partnerDashboard),e.$quickOrder&&e.$utilityBar.appendChild(e.$quickOrder),e.$miniCart&&e.$utilityBar.appendChild(e.$miniCart),e.$viewNotifications&&!document.documentMode&&e.$utilityBar.appendChild(e.$viewNotifications)},e.Small=function(){e.$accountDropdown&&e.$drawer2.appendChild(e.$accountDropdown),e.$partnerDashboard&&e.$drawer2.appendChild(e.$partnerDashboard),e.$miniCart&&e.$utilityBar.appendChild(e.$miniCart),e.$viewNotifications&&!document.documentMode&&e.$utilityBar.appendChild(e.$viewNotifications),e.$quickOrder&&e.$drawer1.appendChild(e.$quickOrder)},e.init=function(){switch(currentBreakpoint=getCurrentViewportSize(),currentBreakpoint){case"xl":case"lg":e.Large();break;case"md":case"sm":e.Medium();break;case"xs":e.Small()}},e.initMiniCartCount=function(){var e=".minicart-number-holder-"+(window.innerWidth<=979?"mobile":"desktop"),i=document.querySelector(e),t=null!=i?i.parentNode.querySelector(".icon"):null,r=getCookie("MiniCartTotalItems");r&&r>0&&t&&(t.classList.remove("cart-icon-empty"),i.classList.remove("hidden"),i.classList.add("cart-items-number"),r>9999?(i.innerHTML=9999,t.classList.add("cart-icon-full"),i.classList.add("cart-items-number"),i.classList.remove("hidden")):(i.innerHTML=r,t.classList.remove("cart-icon-full")))},e.init(),e.initMiniCartCount(),e}(utilitybarBase||{});</script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_23"); </script> </div>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_24"); </script>  <script data-inline-file-name='digitaldata.js' data-inline-site='tf'>/* Hash: 468bd07150dbbf Source: /tf/js/dist/digitaldata.js */ (function () { "use strict"; /** * Invoking a Function as a Method * define function as object methods * @type {Object} */ window.digitalData = { user: {}, page: {}, merchandising: {}, getQueryParam : function (param) { var index, key, value, hash; var hashes = window.location.href.slice(window.location.href.indexOf('?') + 1).split('&'); for (index = 0; index < hashes.length; index++) { hash = hashes[index].split('='); key = hash[0]; value = hash[1]; if (key.toUpperCase() === param.toUpperCase()) return value; } return ''; }, getValOnce: function (value, cookieName, expiry, timeUnit) { var currentDate = new Date; var currentCookieValue; // timeUnit of 'm' is minutes represented in milliseconds // thus 86400000 = 24 hours = 1 day var interval = timeUnit == 'm' ? 60000 : 86400000; cookieName = cookieName ? cookieName : 'digitaldata_gvo'; value = value ? value : ''; expiry = expiry ? expiry : 0; currentCookieValue = this.getCookie(cookieName); if (value) { currentDate.setTime(currentDate.getTime() + expiry * interval); this.setCookie(cookieName, value, expiry == 0 ? 0 : currentDate); } return value == currentCookieValue ? '' : value; }, getCookie: function (key) { var result = ""; var cookies = document.cookie ? document.cookie.split('; ') : []; for (var i = 0; i < cookies.length; i++) { var parts = cookies[i].split('='); var name = decodeURIComponent(parts.shift()); var cookie = parts ? parts.join('=') : []; // Prevent storing or parsing of a cookie that we couldn't decode. if (cookie && key === name) { // removes surrounding quotes if (cookie.indexOf('"') === 0) { // This is a quoted cookie as according to RFC2068, unescape... cookie = cookie.slice(1, -1).replace(/\\"/g, '"').replace(/\\\\/g, '\\'); } // parse utf8 characters try { cookie = decodeURIComponent(cookie); } catch (e) {} result = cookie; // we found it, don't bother looking at other cookies break; } } return result; }, setCookie : function(name, value, numDays){ if ( !numDays ) numDays = 31; var expires = new Date(); expires.setTime(expires.getTime() + (1000 * 60 * 60 * 24 * numDays)); document.cookie = name+ '=' + escape(value) + '; path=/; expires=' + expires.toGMTString() + '; domain=.' + this.getMasterDomain() + ';'; }, /** * get the master domain based on business rules */ getMasterDomain : function () { // default the master domain var masterDomain = 'thermofisher.com'; // check for alternate domain portion of URL var regexMatch = document.location.hostname.match(/\.(thermofisher)\.(cn)/i); if (regexMatch !== null) { masterDomain = regexMatch[1] + '.' + regexMatch[2]; } return masterDomain; }, /** * Check if init has been initiated once * @type {Boolean} */ initted: false, /** * @return {Array} method returns an array of a given object's key properties */ init: function () { this.page.country = this.getCookie("CK_ISO_CODE") || 'us'; this.page.language = this.getCookie('CK_LANG_CODE') || 'en'; this.page.siteName = 'thermo'; //hard coded this.initMerchandisingData(); this.initUserData(); this.displayDigitalData(); this.formSubmitEvent(); }, //specific function to set type of the page // need specific function to keep page type separate from other page attributes setPageType: function (type) { this.setPageAttribute('type', type); }, // generic function to set page attributes setPageAttribute: function (key, value) { this.page[key] = value; }, // display digitalData object displayDigitalData: function () { }, // specific function to add an object to digitalData addDigitDataObject: function (key, object) { this[key] = object; }, addChildObjectAttribute: function(child, key, value){ this[child][key] = value; }, initUserData: function(){ var gigyaCookie = this.getCookie("identity_uid"); this.user.gigyaId = ""; this.user.loginStatus = "anonymous"; if( gigyaCookie != ""){ this.user.gigyaId = gigyaCookie; this.user.loginStatus = "logged in"; } }, /** * Check if init has been initiated once * @type {Boolean} */ merchandisingDataInitted: false, initMerchandisingData: function () { // read cid and icid value from session cookie this.merchandising.icid = this.getCookie('s_ev21_tc'); this.merchandising.cid = this.getCookie('s_cmp_tc'); // EMID value this.merchandising.emid = this.getQueryParam("emid"); // referrer by domain if (typeof document.referrer !== 'undefined' && document.referrer.length > 0) { var masterDomain = this.getMasterDomain(); var refReg = document.referrer; var referrerDomain = refReg.match(/:\/\/([^/]+)\//); if (referrerDomain !== null && referrerDomain[1].indexOf(masterDomain) == -1) { this.merchandising.referrer = referrerDomain; } } document.addEventListener('registerMerchandisingData', function (event) { for (var key in event.detail) { console.log("Listener data copied", key, event.detail[key] ); digitalData.merchandising[key] = event.detail[key]; } // Map some analytics attributes to merchandising session attributes digitalData.merchandising.sessionId = digitalData.merchandising.analyticsVisitorID; digitalData.merchandising.s_vi_low = digitalData.merchandising.analyticsVisitorIDLow; digitalData.merchandising.s_vi_high = digitalData.merchandising.analyticsVisitorIDHigh; console.log("digitalData: Captured registerMerchandisingData event"); digitalData.merchandisingDataInitted = true; // Call emailCampaignRecord if the digitalDataAnalyticsListener object is loaded if (typeof digitalDataAnalyticsListener != "undefined") { console.log("digitalData: Calling email campaign record"); digitalDataAnalyticsListener.emailCampaignRecord(); } }); }, formSubmitEvent: function () { var formId = this.getQueryParam("form-submit-id"); if ((formId) && formId !== "" && formId !== null) { var eventDetail = { detail: { form: { id: formId } } }; var formSubmitEvent = new CustomEvent('formSubmit', eventDetail); console.log('form submit event started'); document.dispatchEvent(formSubmitEvent); console.log('form submit event fired', eventDetail); //flush grepToken from Session Storage sessionStorage.removeItem('grepTokenSO'); } }, modalVideoEvent: function (videoId) { if (((videoId) && videoId !== "" && videoId !== null)) { var eventDetail = { detail: { video: { playerId: videoId } } }; var modalVideoEvent = new CustomEvent('videoPlayerLoaded', eventDetail); document.dispatchEvent(modalVideoEvent); } }, customClickEvent: function (clickDetail) { if (((clickDetail) && clickDetail !== "" && clickDetail !== null)) { var eventDetail = { detail: { CustomLink: { linkName: clickDetail } } } var customClickEvent = new CustomEvent('customLinkClicks', eventDetail); document.dispatchEvent(customClickEvent); } } } })(); window.digitalData.init(); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_25"); </script> <script type="text/javascript"> var localizedStrings = { "ACCEPTANCE": "Acceptance of Terms of Use", "BTN_AGREE": "Agree", "BTN_DISAGREE": "Disagree", "PROCESSING_MESSAGE" :"processing ... please wait ...", "ADD_TO_CART_QUANTITY_ERROR":"You must provide a quantity to add an item to the cart", "ADD_TO_CART_VALID_QUANTITY_ERROR":"You must provide a valid quantity to add an item to the cart", "VIEW_CART" :"View cart & checkout", "VIEW_CONTACT_DETAIL" :"View Contact Details", "ADD_TO_CART_NOTIFICATION":"Add to Cart Notification", "UPDATE_CART" :"Update Cart", "PRINCIPAL_INVESTIGATOR":"Principal Investigator", "PRINCIPAL_INVESTIGATOR_TEAM_LEADER":"Principal Investigator or Team Leader", "PRINCIPAL_INVESTIGATOR_CHIEF":"Principal Investigator or Chief", "EMAIL_ERROR_1" :"Please Provide Collegues Email", "EMAIL_ERROR_2" :"Please enter a valid colleague email address", "EMAIL_ERROR_3" :"Please Provide Your Email", "EMAIL_ERROR_4" :"Please enter a valid email address", "ERROR_OCCURED_MESSAGE" :"The following errors occured", "NEXT" :"Next", "PREVIOUS" :"Prev", "IMAGE" :"Image", "SAVE_TO_LIST_ERROR_1" :"Please enter a list name.", "SAVE_TO_LIST_ERROR_2" :"Please enter a different list name that does not include the following: ?,/,\\,%,^,!", "MINICART_ERROR_1" :"Unable to connect to eCommerce system. Please try again later.", "MINICART_ERROR_2" :"Please enter a quantity in the range of 1 to 999.", "MINICART_ERROR_3" :"Could not add item(s) to cart.", "MINICART_ERROR_4" :"Could not remove item from cart.", "MINICART_ERROR_5" :"Could not create/restore cart.", "MINICART_ERROR_6" :"Unable to retrieve cart details. Please try again later.", "MINICART_MESSAGE_1" :"Adding item(s) to cart...", "MINICART_MESSAGE_2" :"Removing item(s) from cart...", "MINICART_CART_NAME_LABEL_1" :"Recently added to the", "MINICART_NOTE_1" : "Your total price and product details can be viewed in the cart.", MINICART_SUMMARY : "Cart summary", MINICART_PRICE : "Price", MINICART_PRODUCT : "Product", LIST_PRICE : "Price", YOUR_PRICE : "Your price", WEB_PRICE: "Online offer", PRICE_ENDS: "ends", SIGN_IN: "Sign in", //New mini cart CATALOG_NUMBER: "Catalog number:", CONTACT_US: "Contact us", RFQ: "Request quote", LEARN_WHERE_TO_BUY: "Learn where to buy", CURRENCY: "USD", //End new mini cart "CHANGE_CART" :"Change cart", "VIEW_ALL" :"View All", "ITEM" :"item", "ITEMS" :"items", "CLOSE" :"Close", "SUBTOTAL" :"Subtotal", "TOTAL" :"Total", "MANAGE_CART" :"Manage Cart", "FIELD" :"field", "GLOBAL_ERROR_1" :"Please choose one or both of the options for", "GLOBAL_ERROR_2" :"is not a valid e-mail address.", "GLOBAL_ERROR_3" :"Unsupported character(s) were found in field", "GLOBAL_ERROR_4" :"and will be replaced with plain text equivalents (where available). Please review the changes and try again.", "GLOBAL_ERROR_5" :"Please fill in the", "GLOBAL_ERROR_6" :"Quantities must be whole numbers greater than or equal to zero.", "GLOBAL_ERROR_7" :"is either not a number or a number less than zero, please provide a numerical quantity", "GLOBAL_ERROR_8" :"Reserved character | not allowed. Please remove and try again.", "required" : "One or more required fields are missing", "requireOneOfMany" : "At least one field in the group must be filled out", "password" : "Password does not conform to the password policy", "passwordConfirm" : "Password and Confirm Password do not match", "emailConfirm" : "Email and Confirm Email do not match", "secretConfirm" : "Secret Answer and Confirm Secret Answer do not match", "alphanumeric" : "Value must be alphanumeric", "phone" : "Phone number or Fax number provided were non-numeric values", "email" : "Email address provided is in an invalid format", "date" : "Date is in an invalid format (ex. MM/DD/YYYY)", "expirationDate" : "Expiration date provided is invalid", "currency" : "Currency is in an invalid format", "creditCard" : "Credit card number is invalid", "quantity" : "Quantity must in the range of 1 - 999", "acceptance" : "The terms and conditions must be accepted to continue", "checkboxes" : "At least one item must be selected", "twoOrMorecheckboxes" : "Merging carts requires multiple carts to be selected", "file" : "A file must be selected to upload", "NEW_USER" :"New user", "REGISTER_NOW" :"Register Now", "LOGIN_WIDGET_MESSAGE1" :"View your contract prices and real-time product availability.", "WELCOME" :"Welcome", "MY_ACCOUNT" :"My Account", "FAVORITES" :"Favorites", "SAVED_LISTS" :"Saved Lists", "ORDER_STATUS" :"Order Status", "LOGOUT" :"Logout", "APPROVALS" :"Approvals", "REMOVE" :"Remove", "QUANTITY" :"Qty", "EDIT" :"Edit", "SEARCH_BOX_TEXT" :"",//"Search by catalog number or keyword", "SELECT_LANGUAGE" :"Select a Language", "MY_MESSAGES" :"My Messages", "MESSAGE_ALERTS" :"Message Alerts", "B2B_NEW_WINDOW_ALERT" :"You are about to open a new browser window. \nClicking an external link on our site causes a new window to open. However, your shopping session will remain active in this window.Simply return here to continue shopping. \n Would you like to proceed?", "GREETING" :"", "SCMS_SHIP_TO_LAB" :"Ship To Lab", "SCMS_SHIP_TO_SC" :"Supply Center Order", "SCMS_SHIP_TO_SC_FOR_EU":"Supply Centre Order", "SUBMIT" :"Submit", "SUBMIT_ERROR_VALIDATE_EMAIL":"Sorry - we could not validate your email address. Please try again. ", "SUBMIT_ERROR_SERVER" :"We had an issue handling your request - please try again later.", "RECENT_SEARCHES" :"Recent searches", "inText" :"in", "searchSuggestions" :"Search suggestions", "RECENTLYVIEWED_TITLE" : "Recently Viewed Items", "RECENTLYVIEWED_DELETE" : "Remove", "RECENTLYVIEWED_TODAY" : "Today", "RECENTLYVIEWED_PAGINATE": "{C} of {T}", DF_MONTH_0:"January", DF_MONTH_1:"February", DF_MONTH_2:"March", DF_MONTH_3:"April", DF_MONTH_4:"May", DF_MONTH_5:"June", DF_MONTH_6:"July", DF_MONTH_7:"August", DF_MONTH_8:"September", DF_MONTH_9:"October", DF_MONTH_10:"November", DF_MONTH_11:"December", DF_WEEKDAY_0:"Sun", DF_WEEKDAY_1:"Mon", DF_WEEKDAY_2:"Tue", DF_WEEKDAY_3:"Wed", DF_WEEKDAY_4:"Thu", DF_WEEKDAY_5:"Fri", DF_WEEKDAY_6:"Sat", DF_FORMAT:"{0}, {2} {1}" }; var localizedImage = { "LOGIN_WIDGET_EXPAND":"/shared-static/images/buttons/loginWidgetExpand.gif", "LOGIN_WIDGET_MY_ACCOUNT_EXPAND":"/shared-static/images/buttons/loginWidgetMyAccountExpand.gif", "LOGIN_WIDGET_CONTRACT":"/shared-static/images/buttons/loginWidgetContract.gif", "LOGIN_WIDGET_MY_ACCOUNT_CONTRACT":"/shared-static/images/buttons/loginWidgetMyAccountContract.gif", "LOGOUT_BUTTON":"/shared-static/images/login/useraccount.gif", "CLOSE_SESSION_COOL":"/shared-static/images/login/Close-Session-Cool.JPG", "ICON_CLOSE":"/shared-static/images/login/icon_close.GIF" }; var localizedLink = { "B2B_CHECK_OUT_LINK":"/en/US/procurement/lt?cmd=ViewCart&ShoppingCartKey=", "B2B_MANAGE_CART_LINK":"/en/US/procurement/lt?cmd=OILDataDisplay&ShoppingCartKey=", "B2B_VIEW_ALL_LINK":"/en/US/procurement/lt?cmd=ViewCart&ShoppingCartKey=", "LIGGED_IN_CHECKOUT_LINK":"/en/US/direct/lt?cmd=ViewCart&ShoppingCartKey=", "LOGGED_IN_MANAGE_CART_LINK":"/en/US/direct/lt?cmd=OILDataDisplay&ShoppingCartKey=", "LOGGED_IN_VIEW_ALL_LINK":"/en/US/direct/lt?cmd=ViewCart&ShoppingCartKey=", "ANONYMOUS_CHECKOUT_LINK":"/en/US/adirect/lt?cmd=ViewCart&ShoppingCartKey=", "ANONYMOUS_MANAGE_CART_LINK":"/en/US/adirect/lt?cmd=OILDataDisplay&ShoppingCartKey=", "ANONYMOUS_VIEW_ALL_LINK":"/en/US/adirect/lt?cmd=ViewCart&ShoppingCartKey=", "PRODUCT_DETAIL_URL_B2B":"/en/US/procurement/lt?cmd=catProductDetail&productID=", "PRODUCT_DETAIL_URL_ANONYMOUS":"/en/US/adirect/lt?cmd=catProductDetail&productID=", "PRODUCT_DETAIL_URL_LOGGED_IN":"/en/US/direct/lt?cmd=catProductDetail&productID=", "MY_ACCOUNT_LINK_CSR":"/en/US/enterpriseMgr/lt?cmd=HomeDataDisplay", "QUICK_ORDER_ANONYMOUS":"/en/US/adirect/lt?cmd=IVGNQuickOrderLanding", "MY_ACCOUNT_LINK_B2B":"/en/US/procurement/lt?cmd=PartnerSysUserMyAccount", "ORDER_STATUS_LINK_B2B":"/en/US/procurement/lt?cmd=WorkspaceDataDisplay&_Tab=Ordered", "MY_ACCOUNT_LINK":"/en/US/direct/lt?cmd=PartnerSysUserMyAccount", "ORDER_STATUS_LINK":"/en/US/direct/lt?cmd=WorkspaceDataDisplay&_Tab=Ordered", "COMERGENT_CLOSE_SESSION_LINK":"/en/US/procurement/lt?cmd=PunchInOrder&mode=Cancel", "REGISTRATION_URL":"/en/US/adirect/lt?cmd=FullRegistrationData&GroupKey=103&Command=updateExecute&anonymousHomePageMsg=OnlineOrderingPageDisplay", "LIGGED_IN_CHECKOUT_LINK_SCMS":"/en/US/direct/lt?cmd=ViewCart&ShoppingCartKey=", "SCMS_CHECKOUT_SC":"/en/US/procurement/lt?cmd=SetSCMSAddress", "SCMS_CHECKOUT":"/en/US/procurement/lt?cmd=ViewCart&ShoppingCartKey=", "PSCMS_CHECKOUT_SC":"/en/US/procurement/lt?cmd=PSCMSCheckout", "GUEST_USER_AUTH_REDIRECT":"/en/US/procurement/lt?cmd=B2BMasterUserRegistration&operation=identifyUser", "GUEST_USER_AJAX_AUTH":"/en/US/procurement/lt?cmd=B2BMasterUserRegistration&operation=validateNLogin", "GUEST_USER_AJAX_AUTH_UNIQUE_EXPRESS":"/en/US/procurement/lt?cmd=ExpressUniqueUserEmailUpdate", "GUEST_USER_SEARCH_TOOL":"/en/US/direct/lt?cmd=WorkspaceDataDisplay&_Tab=Ordered" }; var localizedMasterUserPopoverSettings = { title:'', content_template: '<div><span class="master-user-popover-close-button">x</span><p class="content_fill">Please enter your email address to use this feature.</p>'+ '<form class="masterUserEmailSubmit form-inline" action="" method="post" onsubmit="return false;">'+ '<div class="auth-error-messaging">'+ '<small class="text-error error-form error-required hide">'+localizedStrings.EMAIL_ERROR_4+'</small>'+ '<small class="text-error error-form error-invalid hide">'+localizedStrings.EMAIL_ERROR_4+'</small>'+ '<small class="text-error error-form error-register hide">'+localizedStrings.SUBMIT_ERROR_SERVER+'</small>'+ '<small class="text-error error-form error-communicate hide">'+localizedStrings.SUBMIT_ERROR_VALIDATE_EMAIL+'</small>'+ '</div>'+ '<span class="control-group">'+ '<input type="text" name="masterUserEmailAddress" class="masterUserEmailAddress input-medium" />'+ '</span> '+ '<input type="button" class="btn btn-primary button primary-button" value="'+localizedStrings.SUBMIT+'" />'+ '<input type="hidden" name="return-url" class="return-url" />'+ '<input type="hidden" name="return-url-is-function-call" class="return-url-is-function-call" />'+ '</form>', content_ordering: '<p class="content_fill content_ordering_fill">Please enter your email address to see order history. Or, you can <a href="#" class="link_search_tool">use the search tool</a> to look for individual orders.</p>', html:true, trigger:'manual', template: '<div class="popover" style="width: 300px; max-width: none;"><div class="arrow"></div><div class="popover-inner"><h3 class="popover-title"></h3><div class="popover-content"><p></p></div></div></div>' }; </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_26"); </script>   <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("globalHeader:renderEnd"); </script> <div class="full-bg" id="full-bg"></div> <div class="search-bg" id="search-bg"></div> </div> </header>  <script>var useNewJquery = 'PatternLibrary';</script> <link href="/etc/designs/lifetech/clientlibs/base.min.css" rel="stylesheet" rel="preload" as="style" /> <link href="/etc/designs/lifetech/clientlibs/base-responsive.css" rel="stylesheet" rel="preload" as="style" /> <script type="text/javascript" src="/etc/designs/lifetech/clientlibs/base-jquery.min.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript" src="/etc/designs/lifetech/clientlibs/base-bootstrap.min.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script src="/shared-static/scripts/global-variables.js"></script> <script src="/shared-static/scripts/global-functions.js"></script> <script src="/shared-static/scripts/environmenturl.js"></script> <script src="/etc/designs/komodo/clientlibs/s_code.js"></script> <script src="/shared-static/scripts/jquery.ivgnModal.js"></script>  <div class="genomic-product-search genomic-product-search-contents content group container page-PDP"> <div class="contents row-fluid"> <div class="span12">    <script type="text/javascript"> if (typeof window.$m === 'undefined' || !window.$m) { window.$m = {}; } window.$m.productName ='Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8)'; if (typeof window.$mangular === 'undefined' || !window.$mangular) { window.$mangular = {}; } window.$mangular.productCategory = 'Antibody'; window.$mangular.productType = 'antibody'; window.$mangular.productSubType = 'Antibody'; window.$mangular.antibodyAspireLink = '/us/en/home/products-and-services/aspire-member-program.html?cid=bid_asp_sbu_r02_co_cp1438_pjt7721_col015466_0wm_tfs_df_awa_at_s00_PCAAntibodyPDP2021'; window.$mangular.ComergentHost = 'www.thermofisher.com' window.$mangular.contryCode = 'sg'; window.$mangular.languageCode = 'en'; window.$mangular.allowShowMoreShowLess = 'false'; window.$mangular.newImageGalleryElisa ='true'; window.$mangular.videoInImageGallery = 'true'; window.$mangular.relatedProducstWidgetV2 ='true'; window.$mangular.brightcoveAccountId = '3663210762001'; window.$mangular.referenceSortByFilterRemoved = 'true'; window.$mangular.techSupportModalEmailFormUrl = 'https://www.thermofisher.com/sg/en/home/technical-resources/contact-us/ext-antibody-technical-support.MN1020.html'; window.$mangular.referenceFilterEnabled = 'true'; window.$mangular.galleryFilterEnabled = 'true'; window.$mangular.isB2BUser = 'false'; window.$mangular.isFullSizeImageEnabled = 'true'; window.$mangular.productWebName = 'Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8)'; window.$mangular.chatBaseApiUrl = 'https://chat-api.thermofisher.com'; window.$mangular.newChatGateWayEnabled = 'false'; window.$mangular.countryCode = 'sg'; window.$mangular.promoAdEnabled = 'true'; </script> <link rel="stylesheet" type="text/css" href="/order/genome-database/assets/css/font-common.css?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"/> <link rel="stylesheet" type="text/css" href="/order/genome-database/assets/js/angular/dist/pdp/antibody.pdp.dist.css?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"/> <link rel="stylesheet" type="text/css" href="/order/genome-database/assets/core/dist/angular/gallery-module/gallery-module.css?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"/> <svg xmlns="http://www.w3.org/2000/svg" display="none"> <style> .fill-color { fill:var(--fill-svg-path); } </style> <symbol id="icon-data-sheet" viewBox="0 0 21 17"> <g stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g transform="translate(-116.000000, -584.000000)"> <g transform="translate(116.000000, 584.000000)"> <path class="fill-color" d="M0,16.5249711 L5.00100002,16.5249711 L5.00100002,3.30482752 L0,3.30482752 L0,16.5249711 Z M1.66700001,14.8571376 L3.33400002,14.8571376 L3.33400002,4.97182752 L1.66700001,4.97182752 L1.66700001,14.8571376 Z" ></path> <path class="fill-color" d="M7.50150003,16.5249711 L12.5025001,16.5249711 L12.5025001,8.26248554 L7.50150003,8.26248554 L7.50150003,16.5249711 Z M9.16850004,14.8571376 L10.8355,14.8571376 L10.8355,9.92865205 L9.16850004,9.92865205 L9.16850004,14.8571376 Z" ></path> <path class="fill-color" d="M15.0030001,16.5249711 L20.0040001,16.5249711 L20.0040001,0 L15.0030001,0 L15.0030001,16.5249711 Z M16.6700001,14.8579711 L18.3370001,14.8579711 L18.3370001,1.66700001 L16.6700001,1.66700001 L16.6700001,14.8579711 Z" ></path> </g> </g> </g> </symbol> <symbol id="icon-protocols" viewBox="0 0 22 20"> <g stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g transform="translate(-1.000000, -2.000000)"> <path class="fill-color" d="M17.8,2.5l3.8,3.8c0.5,0.5,0.5,1.4,0,1.9l-5.4,5.4c-0.5,0.5-1.4,0.5-1.9,0L13,12.3l-1.1,1.1 l1.2,1.2c0.5,0.5,0.5,1.4,0,1.9l-5.4,5.4c-0.5,0.5-1.4,0.5-1.9,0l-3.8-3.8c-0.5-0.5-0.5-1.4,0-1.9l5.4-5.4c0.5-0.5,1.4-0.5,1.9,0 l1.1,1.1l1.1-1.1l-1.1-1.1c-0.5-0.5-0.5-1.4,0-1.9l5.4-5.4C16.4,1.9,17.3,1.9,17.8,2.5z M8.4,12.8L4,17.2l2.8,2.8l4.5-4.5 l-0.8-0.8L9.3,16l-1.4-1.4L9,13.4L8.4,12.8z M16.8,4.3l-4.5,4.5L13,9.4l1.1-1.1l1.4,1.4l-1.1,1.1l0.8,0.8l4.5-4.5L16.8,4.3z" /> </g> </g> </symbol> <symbol id="icon-create-citation" viewBox="0 0 23 21"> <g stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g transform="translate(-260.000000, -582.000000)"> <path class="fill-color" d="M272.324583,582 L262.476833,593.568087 L261.673833,598.68327 L260,600.221115 L260,602 L282,602 L282,600.221115 L262.672083,600.221115 L262.858167,600.047674 L268.246333,598.191408 L278.095917,586.624211 L272.324583,582 Z M264.041583,594.345459 L272.57025,584.505559 L275.51275,586.862581 L266.983167,596.701592 L264.041583,594.345459 Z M263.96,596.402739 L265.097583,597.314418 L263.71525,597.813395 L263.96,596.402739 Z" id="Page-1" transform="translate(271.000000, 592.000000) rotate(-1.000000) translate(-271.000000, -592.000000) "></path> </g> </g> </symbol> <symbol id="icon-qna" viewBox="0 0 19 22"> <path class="fill-color" d="M8,11.34h2v2H8ZM6,7.21a3.06,3.06,0,0,1,.23-1.15,2.56,2.56,0,0,1,1.52-1.5A3.14,3.14,0,0,1,9,4.34a4,4,0,0,1,1.45.23,2.87,2.87,0,0,1,.93.56,1.94,1.94,0,0,1,.51.73,2,2,0,0,1,.15.72,2.42,2.42,0,0,1-.15.92,2.18,2.18,0,0,1-.38.61,2.59,2.59,0,0,1-.5.44l-.52.36a2.09,2.09,0,0,0-.43.41,1.09,1.09,0,0,0-.24.58v.44H8.13V9.82A2.46,2.46,0,0,1,8.34,9a2.36,2.36,0,0,1,.38-.57A2.88,2.88,0,0,1,9.18,8c.17-.12.32-.24.45-.35A2,2,0,0,0,10,7.27a1.07,1.07,0,0,0,.12-.53A1.05,1.05,0,0,0,9.81,6a1.07,1.07,0,0,0-.76-.25,1.26,1.26,0,0,0-.57.12,1,1,0,0,0-.39.33,1.2,1.2,0,0,0-.22.47,2.21,2.21,0,0,0-.08.59Z"/> <g> <path class="fill-color" d="M4.1,22V16.55H0V0H19V16.55H11.43ZM2,14.55H6.1V18l4.67-3.46H17V2H2Z"/> </g> </symbol> <symbol id="icon-tech-support" viewBox="0 0 25 20"> <g stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g transform="translate(-424.000000, -582.000000)" fill-rule="nonzero"> <g transform="translate(424.000000, 582.000000)"> <g> <path class="fill-color" d="M19.8028437,4.49241085 L20.6158492,4.49241085 L23,4.49241085 L23,2 L16,2 L16,4.49241085 L19.0144231,4.49241085 L19.0144231,5.26028879 L19.8028437,4.49241085 Z M20.6158492,6.49241085 L17.0144231,10 L17.0144231,6.49241085 L14,6.49241085 L14,0 L25,0 L25,6.49241085 L20.6158492,6.49241085 Z" id="Combined-Shape"></path> <path class="fill-color" d="M8.5,14 C6.01471863,14 4,11.9852814 4,9.5 C4,7.01471863 6.01471863,5 8.5,5 C10.9852814,5 13,7.01471863 13,9.5 C13,11.9852814 10.9852814,14 8.5,14 Z M8.5,12 C9.88071187,12 11,10.8807119 11,9.5 C11,8.11928813 9.88071187,7 8.5,7 C7.11928813,7 6,8.11928813 6,9.5 C6,10.8807119 7.11928813,12 8.5,12 Z" id="Oval-2"></path> <path class="fill-color" d="M0.613568084,20 L1.0511019,18.6844174 C2.50568865,14.3107461 5.04750487,12 8.5999882,12 C12.1640717,12 14.6451209,14.3259794 15.9580242,18.7133126 L16.3430636,20 L0.613568084,20 Z M13.5943938,18 C12.4931866,15.2747206 10.8472364,14 8.5999882,14 C6.34912378,14 4.64995118,15.278916 3.45203497,18 L13.5943938,18 Z" id="Path-7"></path> </g> </g> </g> </g> </symbol> <symbol id="icon-published-figures" viewBox="0 0 14 17"> <g stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g transform="translate(-119.000000, -363.000000)" fill="#222222"> <path d="M131.133333,378.111122 L121.8,378.111122 C121.338,378.111122 120.969333,377.763568 120.896533,377.315904 L129.442133,377.315904 L130.375467,377.315904 L130.375467,376.371465 L130.375467,366.678685 L131.133333,366.678685 L131.133333,378.111122 Z M121.8,364.888973 L128.507867,364.888973 L128.507867,375.427025 L120.866667,375.427025 L120.866667,365.833412 C120.866667,365.312082 121.285733,364.888973 121.8,364.888973 Z M130.375467,364.789807 L130.375467,363.944534 L130.375467,363.000094 L129.442133,363.000094 L121.8,363.000094 C120.320667,363.000094 119.122267,364.163644 119.0196,365.63508 C119.015867,365.66908 119,365.698357 119,365.734246 L119,365.833412 L119,376.371465 L119,377.166682 L119,377.315904 L119.014933,377.315904 C119.093333,378.810007 120.303867,380 121.8,380 L133,380 L133,364.789807 L130.375467,364.789807 Z" id="Page-1"></path> </g> </g> </symbol> <symbol id="icon-references" viewBox="0 0 13 19"> <g stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g transform="translate(-375.000000, -465.000000)" fill="#333333" fill-rule="nonzero"> <path d="M386,466.999459 C385.999749,466.999679 383.000669,466.999859 377.00276,467 C377.001684,467 377.000764,471.346542 377,480.039626 L381.5,476.720461 L386,480.039626 L386,466.999459 Z M375,466.997422 C375,465.894276 375.893543,465 377.00276,465 L385.99724,465 C387.103334,465 388,465.890925 388,466.997422 L388,484 L381.5,479.205651 L375,484 L375,466.997422 Z" id="Rectangle-11"></path> </g> </g> </symbol> <symbol id="icon-performance-guarantee" viewBox="0 0 17 20"> <defs> <style>.cls-1{fill:#1e8ae7;}.cls-2{fill:#fff;}</style> </defs> <polygon class="cls-1" points="0 0 0 15.63 8.55 20 17 15.63 17 0 0 0"/> <g> <g> <g> <polygon class="cls-2" points="7.38 12.66 3.34 9.07 4.66 7.58 7.38 9.98 12.34 5.58 13.66 7.07 7.38 12.66"/> </g> </g> </g> </symbol> <symbol id="icon-advanced-verification" viewBox="0 0 14 14"> <g stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g transform="translate(-143.000000, -531.000000)" fill="#E71316"> <g transform="translate(135.000000, 526.000000)"> <g transform="translate(8.000000, 5.000000)"> <g id="advanced-verification-icon"> <polygon id="Path-8" fill-rule="nonzero" points="9.82562882 4.6077322 10.8059501 5.70805727 6.18058487 9.82897051 3.19404987 7.16815328 4.17437118 6.0678282 6.18058487 7.85524002"></polygon> <path d="M7,12.5263158 C10.0520999,12.5263158 12.5263158,10.0520999 12.5263158,7 C12.5263158,3.94790007 10.0520999,1.47368421 7,1.47368421 C3.94790007,1.47368421 1.47368421,3.94790007 1.47368421,7 C1.47368421,10.0520999 3.94790007,12.5263158 7,12.5263158 Z M7,14 C3.13400675,14 0,10.8659932 0,7 C0,3.13400675 3.13400675,0 7,0 C10.8659932,0 14,3.13400675 14,7 C14,10.8659932 10.8659932,14 7,14 Z" id="Oval-3-Copy" fill-rule="nonzero"></path> </g> </g> </g> </g> </g> </symbol> <symbol id="icon-select" viewBox="0 0 32 32"> <path d="M16 22.976l-15.68-13.952h31.36z"></path> </symbol> <symbol id="icon-technical-guide-and-protocol" viewBox="0 0 24 24"> <path class="fill-color" d="M13.9,1.1c0.6,0,1.2,0.3,1.4,0.9l0.6,1.1H20v19.6H3.7V3.1h4.1l0.6-1.1 c0.3-0.5,0.8-0.9,1.4-0.9H13.9z M6.9,5.1l-1.2,0v15.6H18V5.1l-1.2,0c0.1,0.9-0.6,1.7-1.6,1.7H8.5C7.5,6.8,6.8,6,6.9,5.1z M14.8,13.3v2H7.9v-2H14.8z M15.8,10v2H7.9v-2H15.8z M13.7,3.1h-3.6L9.2,4.8h5.3L13.7,3.1z"/> </symbol> <symbol id="icon-sale-tag" viewBox="0 0 17 17"> <path d="M6.85,1H1V6.85L10.17,16,16,10.17ZM4.69,4.69a.88.88,0,1,1,0-1.24A.86.86,0,0,1,4.69,4.69Z"/> </symbol> <symbol id="tooltip-info-icon" viewBox="0 0 16 16" fill="none"> <path d="M8 3C10.76 3 13 5.24 13 8C13 10.76 10.76 13 8 13C5.24 13 3 10.76 3 8C3 5.24 5.24 3 8 3ZM8 1C4.13 1 1 4.13 1 8C1 11.87 4.13 15 8 15C11.87 15 15 11.87 15 8C15 4.13 11.87 1 8 1Z" fill="#0071D0"/> <path d="M7 7V12H9V7H7Z" fill="#0071D0"/> <path d="M7 4V6H9V4H7Z" fill="#0071D0"/> </symbol> <symbol id="tooltip-icon-new" width="16" height="16" viewBox="0 0 16 16" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M8 3C10.76 3 13 5.24 13 8C13 10.76 10.76 13 8 13C5.24 13 3 10.76 3 8C3 5.24 5.24 3 8 3ZM8 1C4.13 1 1 4.13 1 8C1 11.87 4.13 15 8 15C11.87 15 15 11.87 15 8C15 4.13 11.87 1 8 1Z" fill="#70707A"></path> <path d="M7 7V12H9V7H7Z" fill="#70707A"></path> <path d="M7 4V6H9V4H7Z" fill="#70707A"></path> </symbol> <symbol id="supply-center-icon" viewBox="0 0 14 14" fill="none"> <path d="M13.6352 4.98228H12.4043C12.2237 4.98228 12.0763 4.83405 12.0763 4.65247C12.0763 4.47089 12.2237 4.32267 12.4043 4.32267H13.8894C13.9042 4.32267 13.9189 4.32267 13.9337 4.32637C13.9374 4.32637 13.9374 4.32637 13.941 4.32637C13.9558 4.33008 13.9668 4.33008 13.9816 4.33378C13.9926 4.27079 14 4.20779 14 4.14479V3.70752H12.1021C11.9216 3.70752 11.7742 3.55929 11.7742 3.37771C11.7742 3.19613 11.9216 3.04791 12.1021 3.04791H14V2.43276H11.7999C11.6194 2.43276 11.472 2.28453 11.472 2.10295C11.472 1.92137 11.6194 1.77315 11.7999 1.77315H14V1.25805C14 0.628086 13.4914 0.116699 12.865 0.116699H9.98684C9.36036 0.116699 8.8518 0.628086 8.8518 1.25805V4.1522C8.8518 4.78217 9.36036 5.29356 9.98684 5.29356H12.865C13.1635 5.28985 13.4325 5.17127 13.6352 4.98228ZM2.1374 9.58476C0.958147 9.58476 0 10.5445 0 11.7341C0 12.9236 0.958147 13.8834 2.1374 13.8834C3.31666 13.8834 4.27481 12.9236 4.27481 11.7341C4.27481 10.5445 3.32035 9.58476 2.1374 9.58476ZM11.4351 9.58476C10.2522 9.58476 9.29402 10.5445 9.29402 11.7341C9.29402 12.9236 10.2522 13.8834 11.4351 13.8834C12.6181 13.8834 13.5762 12.9236 13.5762 11.7341C13.5762 10.5445 12.6181 9.58476 11.4351 9.58476Z" fill="#E71316"/> <path fill-rule="evenodd" clip-rule="evenodd" d="M3.96989 9.2373L2.16784 11.483L1.70897 11.1106L3.51102 8.86497L3.96989 9.2373Z" fill="#E71316"/> <path d="M1.60305 8.52493C3.41616 8.19883 5.20347 9.39947 5.31772 11.5488C5.3214 11.6488 5.40616 11.7304 5.50566 11.7304H8.04475C8.15162 11.7304 8.23638 11.6414 8.23638 11.534C8.19953 10.3889 8.83706 7.94684 13.1008 7.75044C13.1708 7.74673 13.1966 7.65409 13.134 7.61703C8.59384 4.85629 6.51908 7.4688 6.46012 7.26128C6.15794 6.2311 3.46775 5.90129 1.69887 7.56886C1.63991 7.56886 1.61779 7.76896 1.57357 8.49899C1.57357 8.51752 1.58831 8.52863 1.60305 8.52493Z" fill="#E71316"/> <path fill-rule="evenodd" clip-rule="evenodd" d="M8.04335 6.19454C9.22408 5.88996 10.9582 5.94786 13.2854 7.36267C13.6173 7.56116 13.4544 8.02859 13.1163 8.04648L13.1153 8.04654L13.1143 8.04658C11.0382 8.14221 9.89727 8.78067 9.27624 9.48338C8.65091 10.1909 8.51438 11.0068 8.53104 11.5244L8.53119 11.5292V11.534C8.53119 11.7977 8.3217 12.0268 8.04475 12.0268H5.50566C5.24976 12.0268 5.03437 11.8219 5.02322 11.5628C4.91822 9.60551 3.3074 8.52267 1.66058 8.81575C1.44688 8.86034 1.27876 8.68563 1.27876 8.49899V8.48997L1.2793 8.48096C1.30123 8.11892 1.31835 7.87521 1.33838 7.72161C1.3479 7.64863 1.36074 7.57251 1.38401 7.50902C1.39546 7.47776 1.41772 7.42574 1.46177 7.37776C1.48144 7.35635 1.5054 7.336 1.53324 7.319C2.47317 6.45193 3.64586 6.10402 4.63038 6.10696C5.12861 6.10845 5.59219 6.19975 5.96108 6.3711C6.21127 6.48732 6.43559 6.64957 6.5867 6.86018C6.63313 6.82917 6.68372 6.79591 6.73271 6.76502C7.02301 6.58198 7.45814 6.3455 8.04335 6.19454ZM6.17724 7.34478C6.13481 7.20068 5.99437 7.03969 5.71381 6.90936C5.43802 6.78125 5.06183 6.70116 4.62863 6.69987C3.77278 6.69732 2.74721 7.00218 1.92874 7.75877C1.927 7.76968 1.92507 7.78289 1.923 7.79871C1.91194 7.88353 1.90121 8.00831 1.88882 8.18848C3.71762 8.03347 5.44218 9.28953 5.6057 11.4339H7.94013C7.94191 10.8059 8.12772 9.89038 8.8355 9.08952C9.50117 8.3363 10.5991 7.7177 12.3509 7.51331C10.467 6.52491 9.09774 6.53466 8.18987 6.76886C7.6815 6.89999 7.30313 7.10519 7.04595 7.26735C6.95868 7.32237 6.89955 7.36272 6.84528 7.39974C6.80942 7.42421 6.77567 7.44723 6.73734 7.47208C6.70477 7.4932 6.65044 7.52796 6.5946 7.54814C6.5711 7.55663 6.49901 7.5815 6.4108 7.56282C6.35949 7.55195 6.30402 7.52647 6.25706 7.47976C6.21225 7.4352 6.18898 7.38508 6.17724 7.34478ZM1.55587 8.23226C1.55319 8.2327 1.55051 8.23318 1.54782 8.2337L1.55115 8.2331C1.55272 8.23282 1.55429 8.23254 1.55587 8.23226Z" fill="#E71316"/> <path fill-rule="evenodd" clip-rule="evenodd" d="M4.49592 4.76364C4.4496 4.47087 4.44944 4.4709 4.44927 4.47092L4.44887 4.47099L4.44785 4.47115L4.44497 4.47163C4.44268 4.47202 4.43965 4.47254 4.4359 4.4732C4.42841 4.47453 4.41806 4.47644 4.40503 4.47899C4.37898 4.48408 4.3422 4.49178 4.29627 4.50266C4.2045 4.52439 4.07568 4.55892 3.92252 4.611C3.61719 4.71483 3.20952 4.89027 2.80491 5.17732C1.98407 5.75966 1.19256 6.79295 1.2754 8.54641C1.28313 8.70995 1.42124 8.83623 1.58388 8.82846C1.74652 8.82069 1.8721 8.68181 1.86437 8.51827C1.79244 6.99589 2.46395 6.14483 3.14482 5.66179C3.49106 5.41615 3.84392 5.26363 4.1114 5.17267C4.24465 5.12736 4.35531 5.0978 4.43142 5.07978C4.46942 5.07078 4.49869 5.06469 4.51769 5.06097C4.52719 5.05911 4.53411 5.05785 4.53827 5.05711C4.54035 5.05674 4.54174 5.05651 4.54241 5.05639C4.5426 5.05636 4.54273 5.05634 4.5428 5.05633C4.7033 5.03034 4.81263 4.87857 4.78707 4.71707C4.76149 4.55537 4.6104 4.44515 4.4496 4.47087L4.49592 4.76364Z" fill="#E71316"/> </symbol> <symbol id="external-link" viewBox="0 0 14 14" fill="none"> <path d="M10 10V12H2V4H4V2H0V14H12V10H10Z" fill="#0071D0"/> <path fill-rule="evenodd" clip-rule="evenodd" d="M7.00002 0V2H10.59L4.02002 8.57L5.44002 9.98L12 3.41V7H14V0H7.00002Z" fill="#0071D0"/> </symbol> </svg> <svg xmlns="http://www.w3.org/2000/svg" display="none"> <symbol id="filters-icon-caret-down" viewBox="0 0 32 32"> <path d="M16 22.976l-15.68-13.952h31.36z"/> </symbol> <symbol id="filters-icon-close" viewBox="0 0 10 10"> <line x1="1" y1="1" x2="9" y2="9"/> <line x1="1" y1="9" x2="9" y2="1"/> </symbol> <symbol id="filters-icon-caret-right" viewBox="0 0 32 32"> <path d="m16,22.976l-15.68,-13.952l31.36,0l-15.68,13.952z" transform="rotate(-90 16,16) "/> </symbol> <symbol id="filters-icon-back" viewBox="0 0 20 20"> <g stroke-width="2"> <line x1="2" y1="10" x2="9" y2="3"/> <line x1="1" y1="10" x2="18" y2="10"/> <line x1="2" y1="10" x2="9" y2="17"/> </g> </symbol> </svg> <div class="antibody-new-pdp"> <div class="magellan-grid pdp non-touch"> <div class="pdp-modals"> <div id="benchsciDisclaimerModal" class="modal fade benchsciDisclaimer-Modal" role="dialog" aria-labelledby="benchsci-DisclaimerModal-title">  <div class="modal-content" role="document"> <div class="modal-header-disclaimer"> <h2 class="pdp-sub-heading modal-title disclaimer-modal-title" id="benchsci-DisclaimerModal-title">Disclaimer</h2> <img class="disclaimer-close-cross" data-toggle="modal" data-target="#benchsciDisclaimerModal" src="/order/genome-database/assets/img/x_close.svg"/> </div> <div class="modal-body"> <p> Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented. </p> </div> </div> </div> </div> <div class="pdp-components"> <div id="pdp-components" ng-controller="pdpMainController as $ctrl">  <div block-ui="main" class="block-ui-main"></div> <div class="hero hero-loading-height" ng-class="{'is-loaded':$ctrl.isLoaded, 'with-banner': 'false' == 'true'}"> <div class="container"> <div class="hero-content"> <div class="brand-breadcrumb to-hide-on-mobile row"> <div class="large-span-12 medium-span-12 target_page_breadcrumbs"> <div class="breadcrumb breadcrumb-hide-restricted-only"> <ul class="breadcrumb breadcrumb-hide-restricted-only hero-breadcrumbs"> <li class="active"> <a href="/us/en/home/life-science/antibodies/primary-antibodies.html" target="_self"> Primary Antibodies </a> <span class="divider">&rsaquo;</span> </li> <li class="active"> <a href="/antibody/primary/target/tau" target="_self" class="targetLink"> Tau Antibodies</a> </li> </ul> </div> </div> </div> <svg xmlns="http://www.w3.org/2000/svg" display="none"> <symbol id="close-drawer-icon" viewBox="0 0 22.74 22.74"> <line x1="1.67" y1="1.67" x2="21.33" y2="21.33" style="fill:none;stroke:#555759;stroke-linecap:square;stroke-width:2px"/> <line x1="21.07" y1="1.41" x2="1.41" y2="21.07" style="fill:none;stroke:#555759;stroke-linecap:square;stroke-width:2px"/> </symbol> <symbol id="info-icon" viewBox="0 0 32 32"> <path fill="#1e8ae7" d="M16 10.688c-1.152 0-2.048-0.896-2.048-2.048s0.896-2.048 2.048-2.048c1.152 0 2.048 0.896 2.048 2.048 0 1.088-0.96 2.048-2.048 2.048zM17.792 22.976c0 0.768-0.064 1.152-0.256 1.536-0.256 0.576-0.832 0.896-1.6 0.896-0.704 0-1.28-0.32-1.6-0.896-0.192-0.384-0.256-0.768-0.256-1.536v-8.256c0-0.768 0.064-1.152 0.256-1.536 0.256-0.576 0.832-0.896 1.6-0.896 0.704 0 1.28 0.32 1.6 0.896 0.192 0.384 0.256 0.768 0.256 1.536v8.256zM16 0.64c-8.512 0-15.36 6.848-15.36 15.36s6.848 15.36 15.36 15.36c8.512 0 15.36-6.848 15.36-15.36s-6.848-15.36-15.36-15.36z"></path> </symbol> <symbol id="info-orange-icon" viewBox="0 0 32 32"> <path fill="#ed7700" d="M16 10.688c-1.152 0-2.048-0.896-2.048-2.048s0.896-2.048 2.048-2.048c1.152 0 2.048 0.896 2.048 2.048 0 1.088-0.96 2.048-2.048 2.048zM17.792 22.976c0 0.768-0.064 1.152-0.256 1.536-0.256 0.576-0.832 0.896-1.6 0.896-0.704 0-1.28-0.32-1.6-0.896-0.192-0.384-0.256-0.768-0.256-1.536v-8.256c0-0.768 0.064-1.152 0.256-1.536 0.256-0.576 0.832-0.896 1.6-0.896 0.704 0 1.28 0.32 1.6 0.896 0.192 0.384 0.256 0.768 0.256 1.536v8.256zM16 0.64c-8.512 0-15.36 6.848-15.36 15.36s6.848 15.36 15.36 15.36c8.512 0 15.36-6.848 15.36-15.36s-6.848-15.36-15.36-15.36z"></path> </symbol> </svg> <div class="brand-info"> <p class="brand-name" itemprop="brand">Invitrogen</p> </div> <h1 class="product-name">Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8)</h1> <div class="details-hero" ng-click="$ctrl.toggleImages('ADVANCED_VERIFICATION')"> <a class="link adv-verification-link animated-scroll" href="/sg/en/home/life-science/antibodies/invitrogen-antibody-validation.html"> <svg class="svg-icon advanced-verification-icon"> <use href="#icon-advanced-verification"></use> </svg> Advanced Verification </a> <p class="adv-verification-detail" onclick="window.THERMO_FISHER.pdp.inp.toggleImagesAdvVerificationSmLtr(event, this)"> This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. </p> </div> <div class="details-hero"> <a class="link references-link animated-scroll " href="#references-component-id" onclick="window.THERMO_FISHER.pdp.inp.referencesHero(event, this)"> <svg class="svg-icon references-icon"> <use href="#icon-references"></use> </svg> 911 References </a> </div> <div class="details-hero"> <a class="btn hero-btn hero-view-other" href="/antibody/primary/target/tau"> View all (184) Tau antibodies </a> </div> </div> <div class="links-ab to-show-links-in-sm"> <div class="container"> <div class="link-container"> <a class="link-antibody" href="/order/genome-database/dataSheetPdf?producttype=antibody&productsubtype=antibody_primary&productId=MN1020&version=Local" target="_blank" rel="nofollow"> <span> <svg class="svg-icon data-sheet-icon"> <use href="#icon-data-sheet"></use> </svg> </span> Datasheet </a> </div> <div class="link-container"> <a href="https://www.thermofisher.com/global/en/home/life-science/antibodies/antibodies-learning-center/antibody-protocols.html?icid=antibody-pdp-protocols" target="_blank" class="link-antibody"> <span> <svg class="svg-icon protocols-icon"> <use href="#icon-protocols"></use> </svg> </span> Protocols </a> </div> <div class="link-container"> <a href="/us/en/home/technical-resources/contact-us.MN1020.html?supportType=TS" class="link-antibody"> <span> <svg class="svg-icon tech-support-icon"> <use href="#icon-tech-support"></use> </svg> </span> Tech Support </a> </div> </div> </div> <div class="cmrc-card-cnt" id="antibody_primary"> <div class="price-card-alignmnet" tf-product-order> <aside class="sidecard"> <div ng-switch on="$productOrderCtrl.isMultiPack()"> <div ng-switch-when="true"> <div ng-include="$productOrderCtrl.getTemplatePath()+'product-order-multipack.template.html'"></div> </div> <div ng-switch-default> <div ng-include="$productOrderCtrl.getTemplatePath()+'product-order-singlepack.template.html'"></div> </div> </div> </aside> </div> </div> </div> <div id="createCitationModal" class="modal fade citation-modal" role="dialog" aria-labelledby="createCitationModal-title">  <div class="modal-content" role="document"> <div class="modal-header"> <button type="button" class="close" data-dismiss="modal">×</button> <h4 class="modal-title" id="createCitationModal-title">Cite Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8)</h4> </div> <div class="modal-body"> <textarea id="citationTextArea" rows="5">The following product was used in this experiment: Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8) from Thermo Fisher Scientific, catalog # MN1020, RRID AB_223647.</textarea> </div> <div class="modal-footer">  <button type="button" class="well-red btn btn-danger pull-left" data-dismiss="modal" onclick="copyToClipboard();" > Click to Copy </button>  </div> </div> </div> <script type="application/ld+json"> { "@context": "https://schema.org/", "@type": "BreadcrumbList", "itemListElement": [{ "@type": "ListItem", "position": 1, "name": "Home", "item":"https://www.thermofisher.com" },{ "@type": "ListItem", "position": 2, "name": "Antibodies", "item": "https://www.thermofisher.com/us/en/home/life-science/antibodies.html" },{ "@type": "ListItem", "position": 3, "name": "Tau", "item": "https://www.thermofisher.com/antibody/primary/target/tau" }] } </script> </div> <div class="links-ab to-hide-links-in-sm"> <div class="container"> <div class="link-container"> <a class="link-antibody" href="/order/genome-database/dataSheetPdf?producttype=antibody&productsubtype=antibody_primary&productId=MN1020&version=Local" target="_blank" rel="nofollow"> <span> <svg class="svg-icon data-sheet-icon"> <use href="#icon-data-sheet"></use> </svg> </span> Datasheet </a> </div> <div class="link-container"> <a href="https://www.thermofisher.com/global/en/home/life-science/antibodies/antibodies-learning-center/antibody-protocols.html?icid=antibody-pdp-protocols" target="_blank" class="link-antibody"> <span> <svg class="svg-icon protocols-icon"> <use href="#icon-protocols"></use> </svg> </span> Protocols </a> </div> <div class="link-container"> <a href="/us/en/home/technical-resources/contact-us.MN1020.html?supportType=TS" class="link-antibody"> <span> <svg class="svg-icon tech-support-icon"> <use href="#icon-tech-support"></use> </svg> </span> Tech Support </a> </div> </div> </div> <div id="image-gallery" class="scrollClass image-gallery-loading-height" ng-class="{'is-loaded':$ctrl.isLoaded}"> <div id="tabName" tab-name-value="changeTabValue"></div> <div id="originalProductLink" product-link-value="originalProductLinkValue"></div> <div class="gal-cntr container" tfs-media-gallery sku="'MN1020'" media-items="{'Antibody Testing Data':[{'sku':'MN1020','imageId':'714163','imageUrl':'https://www.thermofisher.com/antibody/images/650/MN1020-PhosphoTau-ICC-20200824211338.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/MN1020-PhosphoTau-ICC-20200824211338.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/MN1020-PhosphoTau-ICC-20200824211338.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/MN1020-PhosphoTau-ICC-20200824211338.jpg?time\u003d20240507','sortOrder':'2','description':'Immunofluorescence analysis of Phospho-Tau (Ser202, Thr205) was performed using 70% confluent log phase SH-SY5Y Retinoic acid 100 nM, 8 days. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8) (Product # MN1020) at 1:100 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32766), (1:2000), for 45 minutes at room temperature (Panel a: Green). Nuclei (Panel b:Blue) were stained with ProLong™ Diamond Antifade Mountant with DAPI (Product # P36962). F-actin (Panel c: Red) was stained with Rhodamine Phalloidin (Product # R415, 1:300). Panel d represents the merged image showing Plasma membrane and cytoskeleton localization. Panel e represents untreated cells showing faint signal Panel f represents control cells with no primary antibody to assess background. The images were captured at 60X magnification.','shortDescription':'Immunofluorescence analysis of Phospho-Tau (Ser202, Thr205) was performed using 70% confluent log phase SH-SY5Y Retinoic acid 100 nM, 8 days. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8) (Product ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'Phospho-Tau (Ser202, Thr205) Antibody in Immunocytochemistry (ICC/IF)','title':'Phospho-Tau (Ser202, Thr205) Antibody (MN1020) in ICC/IF','appAbv':'ICC/IF','appName':'Immunocytochemistry','type':'Antibody Testing Data','journalText':'','sourceType':'1','benchsci':false,'imageName':'MN1020-PhosphoTau-ICC-20200824211338.jpg','benchSciPubmedId':'0'},{'sku':'MN1020','imageId':'714164','imageUrl':'https://www.thermofisher.com/antibody/images/650/MN1020-PhosphoTau-WB-20200824211338.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/MN1020-PhosphoTau-WB-20200824211338.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/MN1020-PhosphoTau-WB-20200824211338.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/MN1020-PhosphoTau-WB-20200824211338.jpg?time\u003d20240507','sortOrder':'3','description':'Western blot was performed using Anti-Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8) (Product # MN1020) and a 60kDa band corresponding to Phospho-Tau (Ser202, Thr205) was observed across cell line tested and increased upon Retinoic acid and the successive Okadaic acid treatments. Whole cell extracts (30 µg lysate) of SH-SY5Y (Lane 1), SH-SY5Y treated with Retinoic acid (10 uM for 8 days) (Lane 2), SH-SY5Y differentiated with retinoic acid and treated with Okadaic acid (100 nM for 6 hours) (Lane 3) were electrophoresed using NuPAGE™ 10% Bis-Tris Protein Gel (Product # NP0301BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with the primary antibody (1:1000) and detected by chemiluminescence with Goat anti-Mouse IgG (H+L) Superclonal™ Recombinant Secondary Antibody, HRP (Product # A28177, 1:5000 dilution) using the iBright FL 1000 (Product # A32752). Chemiluminescent detection was performed using SuperSignal™ West Dura Extended Duration Substrate (Product # 34076).','shortDescription':'Western blot was performed using Anti-Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8) (Product # MN1020) and a 60kDa band corresponding to Phospho-Tau (Ser202, Thr205) was observed across cell line tested and increased upon Retinoic acid and the successive Okadaic acid treatments. Whole cell extracts (30 µg lysate) of SH-SY5Y (Lane 1), SH-SY5Y treated with Retinoic acid (10 uM for 8 days) (Lane 2), S... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'Phospho-Tau (Ser202, Thr205) Antibody in Western Blot (WB)','title':'Phospho-Tau (Ser202, Thr205) Antibody (MN1020) in WB','appAbv':'WB','appName':'Western Blot','type':'Antibody Testing Data','journalText':'','sourceType':'1','benchsci':false,'imageName':'MN1020-PhosphoTau-WB-20200824211338.jpg','benchSciPubmedId':'0'}],'Published Figures':[],'Advanced Verification':[{'sku':'MN1020','imageId':'714162','imageUrl':'https://www.thermofisher.com/antibody/images/650/MN1020-PhosphoTau-AV-ICC-20200824211338.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/MN1020-PhosphoTau-AV-ICC-20200824211338.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/MN1020-PhosphoTau-AV-ICC-20200824211338.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/MN1020-PhosphoTau-AV-ICC-20200824211338.jpg?time\u003d20240507','sortOrder':'1','description':'Detection of altered subcellular localization of the target protein by cell treatment demonstrates antibody specificity. Immunofluorescence analysis using Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8) (Product # MN1020), shows plasma membrane and cytoskeleton localization in SH-SY5Y cells treated with retinoic acid as compared to untreated SH-SY5Y cells which is reported to be low to negative for PhosphoTau expression. {TM}','shortDescription':'Detection of altered subcellular localization of the target protein by cell treatment demonstrates antibody specificity. Immunofluorescence analysis using Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8) (Product # MN1020), shows plasma membrane and cytoskeleton localization in SH-SY5Y cells treated with retinoic acid as compared to untreated SH-SY5Y cells which is reported to be low to negative for P... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'Phospho-Tau (Ser202, Thr205) Antibody','title':'Phospho-Tau (Ser202, Thr205) Antibody (MN1020)','appAbv':'TM','appName':'Cell treatment','type':'Advanced Verification','journalText':'','sourceType':'2','benchsci':false,'imageName':'MN1020-PhosphoTau-AV-ICC-20200824211338.jpg','benchSciPubmedId':'0'}]}" image-displayed-id="'714163'" product-sub-type="'antibody_primary'" prod-type="'antibody'" page-type="PDP" product-id="'MN1020'"> <div class="tabs"> <ul class="nav nav-pills"> <li class="tab" onclick="window.THERMO_FISHER.inp.onTabClick(event, this)" data-tabname="Antibody Testing Data"> <a class="tab-text"> Antibody Testing Data (2) </a> </li> <li class="tab" onclick="window.THERMO_FISHER.inp.onTabClick(event, this)" data-tabname="Advanced Verification"> <a class="tab-text"> Advanced Verification (1) </a> </li> </ul> <div gallery-flt class="gal-flt" is-with-abbr="true" enable-mobile-flt="true" mobile-result-count="true" filter-data="$ctrl.applicationsList" advanced-filter-data="$ctrl.advancedApplicationsList" filter-text="Application" event-name="{{$ctrl.fltAppEvent}}"> </div> </div> <div class="cntnt" ng-swipe-right="$ctrl.clickLeftArrow()" ng-swipe-left="$ctrl.clickRightArrow()"> <div class="nav-arrow" ng-if="!$ctrl.isMobileSmallTabletScreen()" onclick="window.THERMO_FISHER.inp.onClickOfLeftArrow(event, this)"> <div tabindex="0" class="gallery-left-arrows icon-gallery-arrow-left" > </div> </div> <div class="media-text"> <div class="media-display-mobile" ng-if="$ctrl.isMobileSmallTabletScreen()"> <div class="nav-arrow" onclick="window.THERMO_FISHER.inp.onClickOfLeftArrow(event, this)"> <div tabindex="0" class="gallery-left-arrows icon-gallery-arrow-left" > </div> </div> <div class="media-display"> <img id="media-image" class="image" ng-show="!$ctrl.isVideo" src="https://www.thermofisher.com/antibody/images/650/MN1020-PhosphoTau-ICC-20200824211338.jpg?time=20240507" alt="Phospho-Tau (Ser202, Thr205) Antibody in Immunocytochemistry (ICC/IF)" title="Phospho-Tau (Ser202, Thr205) Antibody in Immunocytochemistry (ICC/IF)" longdesc="https://www.thermofisher.com/antibody/images/650/MN1020-PhosphoTau-ICC-20200824211338.jpg?time=20240507?time=20240507" onerror="javascript:imageErrorHandler.call(this, event);" > <div class="hover-text" ng-show="!$ctrl.isVideo"> <a href="javascript:return false;" onclick="window.THERMO_FISHER.inp.openImageGalleryModal(event, this)" aria-label="image-link"> <div class="rectangle"> <div class="expand-logo-rightcorner"> <?xml version="1.0" encoding="utf-8"?>  <svg width="19px" height="19px" version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 22 22" style="enable-background:new 0 0 22 22;" xml:space="preserve"> <style type="text/css"> .st0{fill-rule:evenodd;clip-rule:evenodd;fill:#222222;} </style> <title>Group 53</title> <desc>Created with Sketch.</desc> <g id="Symbols"> <g id="rollover-expand-icon" transform="translate(-8.000000, -8.000000)"> <g id="Group-48"> <g id="Group-53" transform="translate(8.000000, 8.000000)"> <g id="Group-49" transform="translate(0.000000, 0.000000)"> <g id="Group-54"> <g id="Group-55" transform="translate(0.000000, -0.000000)"> <path id="Fill-1" class="st0" d="M21.9,14.6h-2.2c0,1,0,1.9,0,2.9c0,0.2,0,0.4,0,0.6c-0.1-0.1-0.2-0.2-0.3-0.2 c-1.3-1.3-2.7-2.7-4-4l-1.6,1.5c1.3,1.4,2.7,2.7,4,4.1c0.1,0.1,0.1,0.2,0.3,0.3c-0.2,0-0.3,0-0.4,0c-1,0-2.1,0-3.1,0V22 c2.3,0,4.8,0,7.1,0.1c0.1,0,0.2,0,0.3,0c0-0.5-0.1-0.9-0.1-1.3C21.9,18.7,21.9,16.6,21.9,14.6z"/> <path id="Fill-4" class="st0" d="M1.3,21.9c1.9,0,4,0,6,0v-2.2c-1,0-1.9,0-2.9,0c-0.2,0-0.4,0-0.6,0C3.9,19.6,4,19.5,4,19.4 c1.3-1.3,2.7-2.7,3.9-4l-1.5-1.6c-1.3,1.3-2.7,2.7-4,4c-0.1,0.1-0.2,0.1-0.3,0.3c0-0.2,0-0.3,0-0.4c0-1,0-2.1,0-3.1h-2.2 c0,2.3,0,4.7-0.1,7c0,0.1,0,0.2,0,0.3C0.5,21.9,0.9,21.9,1.3,21.9"/> <path id="Fill-7" class="st0" d="M0.1,1.3c0,1.9,0,4,0,6h2.2c0-1,0-1.9,0-2.9c0-0.2,0-0.4,0-0.6C2.4,3.9,2.5,4,2.5,4.1 c1.3,1.3,2.7,2.7,4,3.9l1.6-1.5c-1.3-1.3-2.7-2.7-4-4C4,2.4,3.9,2.3,3.8,2.2c0.2,0,0.3,0,0.4,0c1,0,2.1,0,3.1,0V0 C5,0,2.6,0,0.3,0C0.2,0,0.1,0,0,0C0,0.5,0.1,0.9,0.1,1.3"/> <path id="Fill-10" class="st0" d="M20.7,0.1c-1.9,0-4,0-6,0v2.1c1,0,1.9,0,2.9,0c0.2,0,0.4,0,0.6,0C18,2.4,18,2.5,17.9,2.6 c-1.3,1.3-2.7,2.6-3.9,3.9L15.5,8c1.3-1.3,2.7-2.6,4-4c0.1-0.1,0.2-0.1,0.3-0.2c0,0.2,0,0.3,0,0.4c0,1,0,2,0,3.1H22 c0-2.3,0-4.7,0.1-6.9c0-0.1,0-0.2,0-0.3C21.5,0.1,21.1,0.1,20.7,0.1"/> </g> </g> </g> </g> </g> </g> </g> </svg> </div> </div> </a> </div> </div> <div class="nav-arrow" onclick="window.THERMO_FISHER.inp.onClickOfRightArrow(event, this)"> <div tabindex="0" class="gallery-right-arrows icon-gallery-arrow-right"> </div> </div> </div> <div class="media-display" ng-if="!$ctrl.isMobileSmallTabletScreen()"> <img id="media-image" class="image" ng-show="!$ctrl.isVideo" src="https://www.thermofisher.com/antibody/images/650/MN1020-PhosphoTau-ICC-20200824211338.jpg?time=20240507" alt="Phospho-Tau (Ser202, Thr205) Antibody in Immunocytochemistry (ICC/IF)" title="Phospho-Tau (Ser202, Thr205) Antibody in Immunocytochemistry (ICC/IF)" longdesc="https://www.thermofisher.com/antibody/images/650/MN1020-PhosphoTau-ICC-20200824211338.jpg?time=20240507?time=20240507" onerror="javascript:imageErrorHandler.call(this, event);" > <div class="hover-text" ng-show="!$ctrl.isVideo"> <a href="javascript:return false;" onclick="window.THERMO_FISHER.inp.openImageGalleryModal(event, this)" aria-label="image-link"> <div class="rectangle"> <div class="expand-logo-rightcorner"> <?xml version="1.0" encoding="utf-8"?>  <svg width="19px" height="19px" version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 22 22" style="enable-background:new 0 0 22 22;" xml:space="preserve"> <style type="text/css"> .st0{fill-rule:evenodd;clip-rule:evenodd;fill:#222222;} </style> <title>Group 53</title> <desc>Created with Sketch.</desc> <g id="Symbols"> <g id="rollover-expand-icon" transform="translate(-8.000000, -8.000000)"> <g id="Group-48"> <g id="Group-53" transform="translate(8.000000, 8.000000)"> <g id="Group-49" transform="translate(0.000000, 0.000000)"> <g id="Group-54"> <g id="Group-55" transform="translate(0.000000, -0.000000)"> <path id="Fill-1" class="st0" d="M21.9,14.6h-2.2c0,1,0,1.9,0,2.9c0,0.2,0,0.4,0,0.6c-0.1-0.1-0.2-0.2-0.3-0.2 c-1.3-1.3-2.7-2.7-4-4l-1.6,1.5c1.3,1.4,2.7,2.7,4,4.1c0.1,0.1,0.1,0.2,0.3,0.3c-0.2,0-0.3,0-0.4,0c-1,0-2.1,0-3.1,0V22 c2.3,0,4.8,0,7.1,0.1c0.1,0,0.2,0,0.3,0c0-0.5-0.1-0.9-0.1-1.3C21.9,18.7,21.9,16.6,21.9,14.6z"/> <path id="Fill-4" class="st0" d="M1.3,21.9c1.9,0,4,0,6,0v-2.2c-1,0-1.9,0-2.9,0c-0.2,0-0.4,0-0.6,0C3.9,19.6,4,19.5,4,19.4 c1.3-1.3,2.7-2.7,3.9-4l-1.5-1.6c-1.3,1.3-2.7,2.7-4,4c-0.1,0.1-0.2,0.1-0.3,0.3c0-0.2,0-0.3,0-0.4c0-1,0-2.1,0-3.1h-2.2 c0,2.3,0,4.7-0.1,7c0,0.1,0,0.2,0,0.3C0.5,21.9,0.9,21.9,1.3,21.9"/> <path id="Fill-7" class="st0" d="M0.1,1.3c0,1.9,0,4,0,6h2.2c0-1,0-1.9,0-2.9c0-0.2,0-0.4,0-0.6C2.4,3.9,2.5,4,2.5,4.1 c1.3,1.3,2.7,2.7,4,3.9l1.6-1.5c-1.3-1.3-2.7-2.7-4-4C4,2.4,3.9,2.3,3.8,2.2c0.2,0,0.3,0,0.4,0c1,0,2.1,0,3.1,0V0 C5,0,2.6,0,0.3,0C0.2,0,0.1,0,0,0C0,0.5,0.1,0.9,0.1,1.3"/> <path id="Fill-10" class="st0" d="M20.7,0.1c-1.9,0-4,0-6,0v2.1c1,0,1.9,0,2.9,0c0.2,0,0.4,0,0.6,0C18,2.4,18,2.5,17.9,2.6 c-1.3,1.3-2.7,2.6-3.9,3.9L15.5,8c1.3-1.3,2.7-2.6,4-4c0.1-0.1,0.2-0.1,0.3-0.2c0,0.2,0,0.3,0,0.4c0,1,0,2,0,3.1H22 c0-2.3,0-4.7,0.1-6.9c0-0.1,0-0.2,0-0.3C21.5,0.1,21.1,0.1,20.7,0.1"/> </g> </g> </g> </g> </g> </g> </g> </svg> </div> </div> </a> </div> </div> <div class="media-desc"> <div class="gallery-count"> <p> FIGURE: <span class="current-img"> 1 </span> / <span class="img-total-count"> 3</span></p> </div> <div class = "verification-certificate hide" > <span class="icon-certification"></span> <span class="adv-cert-text">{{ $ctrl.currentElement.advancedVerification.fullName }}</span> <div class="cert-provider">{{ $ctrl.currentElement.advancedVerification.text }}</div> </div> <h2 class="product-name" ng-show="!$ctrl.isVideo"> Phospho-Tau (Ser202, Thr205) Antibody (MN1020) in ICC/IF </h2> <div ng-show="!$ctrl.isVideo"> <div class="image-desc"> <div class="product-desc-text viewing-more-long-description"> <span class="image-journal-text" > </span> <span class="short-desc"> Immunofluorescence analysis of Phospho-Tau (Ser202, Thr205) was performed using 70% confluent log phase SH-SY5Y Retinoic acid 100 nM, 8 days. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8) (Product ... <a href="#" class="images-view-more-text" >View More</a> </span> <span class="verification-info hide" ng-if="$ctrl.hasVerificationMethod"> <a rel="nofollow" ng-href="{{$ctrl.currentElement.advancedVerification.uri}}" >{{ $ctrl.currentElement.advancedVerification.fullName }} validation info.</a> </span> <a href="#" class="images-view-more-text hide" ng-if="$ctrl.showViewMore" onclick="window.THERMO_FISHER.inp.openImageGalleryModal(event, this)"> View more </a> </div> </div> <div class="img-desc-footer"> <div class="benchsci-pubmed-footer"> <div ng-cloak ng-if="$ctrl.currentElement.benchsci || $ctrl.sourceType === '3'" class="images-benchsci-footer"> <div class="images-benchsci-link" tabindex="0"> <span>Published figure supplied by</span> <span class="icon-benchsci-logo"> <svg id="Layer_1" data-name="Layer 1" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 89.75 23.21"><defs><style>.cls-1{fill:#222222;}</style></defs><title>benchsci-logo</title><g id="logo-blue-copy-3"><g id="logo-blue-copy-2"><path id="path14" class="cls-1" d="M34.54,11.49a2.45,2.45,0,0,0,1.59-2.34c0-1.69-1.21-2.94-3.32-2.94H28.88v10.9h4.21a3.06,3.06,0,0,0,3.37-3A2.57,2.57,0,0,0,34.54,11.49ZM31,8h1.49c1,0,1.57.53,1.57,1.36a1.36,1.36,0,0,1-1.55,1.37H31Zm1.72,7.35H31V12.47h1.75a1.42,1.42,0,0,1,1.62,1.46C34.34,14.79,33.72,15.34,32.69,15.34Z"/><path id="path16" class="cls-1" d="M41.34,9.32a3.8,3.8,0,0,0-3.72,4,3.83,3.83,0,0,0,3.91,4.05A3.39,3.39,0,0,0,45,15l-1.71-.51a1.67,1.67,0,0,1-1.72,1.15,1.85,1.85,0,0,1-1.91-1.73H45s0-.34,0-.63C45.09,10.81,43.69,9.32,41.34,9.32Zm-1.66,3.15A1.63,1.63,0,0,1,41.37,11a1.52,1.52,0,0,1,1.69,1.49Z"/><path id="path18" class="cls-1" d="M50.58,9.35a2.48,2.48,0,0,0-2.18,1.14v-1h-2v7.57h2.05V12.75a1.42,1.42,0,0,1,1.41-1.57,1.34,1.34,0,0,1,1.4,1.52v4.42h2V12.35C53.32,10.68,52.46,9.35,50.58,9.35Z"/><path id="path20" class="cls-1" d="M58.2,15.47a1.94,1.94,0,0,1-1.94-2.14,1.92,1.92,0,0,1,1.91-2.12,1.64,1.64,0,0,1,1.67,1.27l1.83-.61a3.45,3.45,0,0,0-3.55-2.55,3.83,3.83,0,0,0-2.82,1.16,3.88,3.88,0,0,0-1.1,2.85,3.9,3.9,0,0,0,4,4,3.5,3.5,0,0,0,3.53-2.55l-1.8-.6A1.72,1.72,0,0,1,58.2,15.47Z"/><path id="path22" class="cls-1" d="M67,9.35a2.72,2.72,0,0,0-2.07.83V6h-2V17.12h2V12.67a1.43,1.43,0,0,1,1.42-1.48,1.34,1.34,0,0,1,1.4,1.53v4.41h2V12.35A2.67,2.67,0,0,0,67,9.35Z"/><path id="path24" class="cls-1" d="M75.82,11.05l-1.63-.35a1.58,1.58,0,0,1-1.4-1.59A1.93,1.93,0,0,1,74.9,7.3a2.21,2.21,0,0,1,2.3,1.86l1.36-.48a3.73,3.73,0,0,0-7.29.54,3,3,0,0,0,2.67,3l1.55.33c1.09.24,1.63.91,1.63,1.7,0,.95-.74,1.74-2.25,1.74a2.51,2.51,0,0,1-1.79-.63,2.45,2.45,0,0,1-.82-1.71l-1.45.46a3.79,3.79,0,0,0,4.08,3.24c2.32,0,3.76-1.52,3.76-3.22C78.65,12.59,77.63,11.45,75.82,11.05Z"/><path id="path26" class="cls-1" d="M83.25,16A2.33,2.33,0,0,1,81,13.41a2.31,2.31,0,0,1,2.24-2.59,1.93,1.93,0,0,1,2,1.57l1.31-.55a3.22,3.22,0,0,0-3.29-2.35,3.7,3.7,0,0,0-3.72,3.92,3.75,3.75,0,0,0,3.74,3.94A3.41,3.41,0,0,0,86.59,15l-1.28-.55A2,2,0,0,1,83.25,16Z"/><path id="path28" class="cls-1" d="M88.69,5.89a1,1,0,1,0,.75.29A1,1,0,0,0,88.69,5.89Z"/><polygon id="rect30" class="cls-1" points="87.99 9.72 89.42 9.72 89.42 17.11 87.99 17.11 87.99 9.72"/><path id="path32" class="cls-1" d="M14.58,8.87A4.1,4.1,0,0,0,15.8,6H14.31a2.62,2.62,0,0,1-.76,1.87L11.66,9.7l-2-2A2.61,2.61,0,0,1,9,6H7.53A4.09,4.09,0,0,0,8.74,8.87l1.87,1.87L8.74,12.61a4.08,4.08,0,0,0-1.21,2.92v2.29H9.18V16.73h1.66v1.09h1.64V16.73h1.65v1.09H15.8V15.53a4.11,4.11,0,0,0-1.21-2.92l-1.38-1.36-1,1.05,1.37,1.36a2.63,2.63,0,0,1,.77,1.58H9a2.68,2.68,0,0,1,.76-1.58Z"/><path id="path34" class="cls-1" d="M11.61,23.21a11.61,11.61,0,1,1,11.6-11.6A11.6,11.6,0,0,1,11.61,23.21Zm0-21.89A10.29,10.29,0,1,0,21.9,11.61,10.28,10.28,0,0,0,11.61,1.32Z"/></g></g></svg> </span> <span id="bechsci-tooltip-{{$ctrl.productId}}" class="bechsci-tooltip-icon" data-toggle="tooltip" ng-click="$ctrl.showBechSciTooltip()" close-tooltip="$ctrl.closeBechSciTooltip()" data-html="true" title="Clicking this link will redirect you to the <a href='https://www.benchsci.com/' target='_blank'> BenchSci</a> website that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented."> <?xml version="1.0" encoding="utf-8"?>  <svg version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 16 16" style="enable-background:new 0 0 16 16;" xml:space="preserve"> <style type="text/css"> .st0{fill-rule:evenodd;clip-rule:evenodd;fill:#A2A2A2;} </style> <g id="Log-In-_x2F_-Out-States"> <g id="_x31_200-00-AB-PDP-Logged-Out-Card" transform="translate(-953.000000, -1013.000000)"> <g id="icons_x2F_16_x2F_info_x2F_bold" transform="translate(952.000000, 1012.000000)"> <path id="Shape" class="st0" d="M9,4c2.8,0,5,2.2,5,5s-2.2,5-5,5s-5-2.2-5-5S6.2,4,9,4 M9,2C5.1,2,2,5.1,2,9s3.1,7,7,7s7-3.1,7-7 c0-1.9-0.7-3.6-2.1-4.9S10.9,2,9,2z M8,8.5v4.4h2V8.5H8z M8,5.2v2h2v-2H8z"/> </g> </g> </g> </svg> </span> </div> </div> <div ng-cloak ng-if="$ctrl.currentElement.benchSciPubmedId && $ctrl.currentElement.benchSciPubmedId != '0'" class="pubmed-link"> <span ng-class="$ctrl.getSeperatorClass()">PMID: <a target="_blank" href="http://pubmed.ncbi.nlm.nih.gov/pubmed/{{ $ctrl.currentElement.benchSciPubmedId }}">{{$ctrl.currentElement.benchSciPubmedId}}</a> </span> </div> </div> <div class="btn-view-product" ng-cloak ng-show="false"> <a role="button" class="btn img-view-product"> View Product </a> </div> </div> </div> <div ng-show="$ctrl.isVideo" class="video-desc hide"> <h2 class="product-name" ng-bind="$ctrl.videoTitle"></h2> <p>{{$ctrl.videoDesc}}</p> <p>{{$ctrl.videoLongDesc}}</p> </div> </div> </div> <div class="nav-arrow" ng-if="!$ctrl.isMobileSmallTabletScreen()" onclick="window.THERMO_FISHER.inp.onClickOfRightArrow(event, this)"> <div tabindex="0" class="gallery-right-arrows icon-gallery-arrow-right"> </div> </div> </div> <image-gallery-key-nav pdp-gallery="true"></image-gallery-key-nav> <div class="film-strip"> <div id="custom-scrollbar" class="set-of-images"> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="714163" data-index="0"> <img src="https://www.thermofisher.com/antibody/images/150/MN1020-PhosphoTau-ICC-20200824211338.jpg?time=20240507" alt="Phospho-Tau (Ser202, Thr205) Antibody in Immunocytochemistry (ICC/IF)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="714164" data-index="1"> <img src="https://www.thermofisher.com/antibody/images/150/MN1020-PhosphoTau-WB-20200824211338.jpg?time=20240507" alt="Phospho-Tau (Ser202, Thr205) Antibody in Western Blot (WB)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="714162" data-index="2"> <img src="https://www.thermofisher.com/antibody/images/150/MN1020-PhosphoTau-AV-ICC-20200824211338.jpg?time=20240507" alt="Phospho-Tau (Ser202, Thr205) Antibody"/> </div> </div> </div> </div> </div> <noscript> <div itemscope itemtype="http://schema.org/ImageGallery"> <h2>Product Image Gallery</h2> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/MN1020-PhosphoTau-ICC-20200824211338.jpg?time=20240507?time=20240507" alt="Phospho-Tau (Ser202, Thr205) Antibody in Immunocytochemistry (ICC/IF)" title="Phospho-Tau (Ser202, Thr205) Antibody (MN1020) in ICC/IF"> <figcaption itemprop="caption">Immunofluorescence analysis of Phospho-Tau (Ser202, Thr205) was performed using 70% confluent log phase SH-SY5Y Retinoic acid 100 nM, 8 days. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8) (Product # MN1020) at 1:100 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32766), (1:2000), for 45 minutes at room temperature (Panel a: Green). Nuclei (Panel b:Blue) were stained with ProLong™ Diamond Antifade Mountant with DAPI (Product # P36962). F-actin (Panel c: Red) was stained with Rhodamine Phalloidin (Product # R415, 1:300). Panel d represents the merged image showing Plasma membrane and cytoskeleton localization. Panel e represents untreated cells showing faint signal Panel f represents control cells with no primary antibody to assess background. The images were captured at 60X magnification.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/MN1020-PhosphoTau-WB-20200824211338.jpg?time=20240507?time=20240507" alt="Phospho-Tau (Ser202, Thr205) Antibody in Western Blot (WB)" title="Phospho-Tau (Ser202, Thr205) Antibody (MN1020) in WB"> <figcaption itemprop="caption">Western blot was performed using Anti-Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8) (Product # MN1020) and a 60kDa band corresponding to Phospho-Tau (Ser202, Thr205) was observed across cell line tested and increased upon Retinoic acid and the successive Okadaic acid treatments. Whole cell extracts (30 µg lysate) of SH-SY5Y (Lane 1), SH-SY5Y treated with Retinoic acid (10 uM for 8 days) (Lane 2), SH-SY5Y differentiated with retinoic acid and treated with Okadaic acid (100 nM for 6 hours) (Lane 3) were electrophoresed using NuPAGE™ 10% Bis-Tris Protein Gel (Product # NP0301BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with the primary antibody (1:1000) and detected by chemiluminescence with Goat anti-Mouse IgG (H+L) Superclonal™ Recombinant Secondary Antibody, HRP (Product # A28177, 1:5000 dilution) using the iBright FL 1000 (Product # A32752). Chemiluminescent detection was performed using SuperSignal™ West Dura Extended Duration Substrate (Product # 34076).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/MN1020-PhosphoTau-AV-ICC-20200824211338.jpg?time=20240507?time=20240507" alt="Phospho-Tau (Ser202, Thr205) Antibody" title="Phospho-Tau (Ser202, Thr205) Antibody (MN1020)"> <figcaption itemprop="caption">Detection of altered subcellular localization of the target protein by cell treatment demonstrates antibody specificity. Immunofluorescence analysis using Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8) (Product # MN1020), shows plasma membrane and cytoskeleton localization in SH-SY5Y cells treated with retinoic acid as compared to untreated SH-SY5Y cells which is reported to be low to negative for PhosphoTau expression. {TM}</figcaption> </figure> </div> </div> </noscript> <div id="tf-related-products-container-new"></div> <div class="product-details"> <div class="container"> <div class="row"> <div class="large-span-12 medium-span-12 small-span-12"> <h2 class="pdp-sub-heading product_details_heading">Product Details</h2></div> <div class="hidden-sku"> <h2>MN1020</h2> </div> <div class="product-detail-section tested-app-section new-tbl-design product-detail-section table-spec"> <div class="product-container-head"> <div class="product-item"> Applications </div> <div class="product-item dilution-lbl-head "> Tested Dilution </div> <div class="product-item published-applications"> Publications </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Western Blot (WB)</h2></div> <div class="product-item "> <span class="dilution-lbl">1:250-1:2,000</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#WB-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 280 publications</span> <span class="mobile-view">280 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry (IHC)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHC-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 472 publications</span> <span class="mobile-view">472 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry (Paraffin) (IHC (P))</h2></div> <div class="product-item "> <span class="dilution-lbl">5-10 µg/mL</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHCP-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 42 publications</span> <span class="mobile-view">42 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry (Frozen) (IHC (F))</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHCF-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 9 publications</span> <span class="mobile-view">9 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry - Free Floating (IHC (Free))</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHCFree-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 16 publications</span> <span class="mobile-view">16 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunocytochemistry (ICC/IF)</h2></div> <div class="product-item "> <span class="dilution-lbl">1:50-1:1,000</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#ICCIF-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 53 publications</span> <span class="mobile-view">53 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Flow Cytometry (Flow)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#Flow-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 4 publications</span> <span class="mobile-view">4 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>ELISA (ELISA)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#ELISA-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 8 publications</span> <span class="mobile-view">8 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunoprecipitation (IP)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IP-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 2 publications</span> <span class="mobile-view">2 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>in situ PLA (PLA)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#PLA-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 1 publication</span> <span class="mobile-view">1 publication</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Dot blot (DB)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#DB-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 1 publication</span> <span class="mobile-view">1 publication</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Inhibition Assays (IA)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IA-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 1 publication</span> <span class="mobile-view">1 publication</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunodiffusion (IDF)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IDF-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 1 publication</span> <span class="mobile-view">1 publication</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Miscellaneous PubMed (Misc)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#Misc-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 21 publications</span> <span class="mobile-view">21 publications</span></a> </div> </div> </div> <div class="product-detail-section tested-app-section new-tbl-design product-specific-section table-spec"> <div class="product-container-head"> <div class="product-item">Product Specifications</div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Species Reactivity</h2> </div> <div class="product-item left-flex-cls"> <span title="Homo sapiens">Human,</span> <span title="Mus musculus">Mouse</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Published species</h2> </div> <div class="product-item left-flex-cls"> <span>C. elegans,</span> <span>Cat,</span> <span>Chimpanzee,</span> <span>Dog,</span> <span>Fruit fly,</span> <span>Hamster,</span> <span>Human,</span> <span>Mouse,</span> <span>Non-human primate,</span> <span>Pig,</span> <span>Rabbit,</span> <span>Rat,</span> <span>Yeast</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2> Host/Isotype</h2> </div> <div class="product-item left-flex-cls"> <span title="Mus musculus">Mouse / IgG1, kappa</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Class</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Monoclonal </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Type</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Antibody </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Clone</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> AT8 </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Immunogen </h2> </div> <div class="product-item left-flex-cls">Partially purified human PHF-Tau <script type="text/javascript"> if (typeof window.$mangular === 'undefined' || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = '[{"targetFamily":"Tau","uniProtId":"P10636-1","ncbiNodeId":"9606","antigenRange":"1-758","antigenLength":"758","antigenImageFileName":"MN1020_Tau_P10636-1_house_mouse.svg","antigenImageFileNamePDP":"MN1020_Tau_P10636-1_house_mouse_PDP.jpeg","sortOrder":"1"}]'; $mangular.isB2BCMGT = '"false"'; $mangular.isEpitopesModalImageMultiSizeEnabled = 'true'; </script> <div class="antigen-link" ng-click="$ctrl.openModal()"> <a href="">View immunogen <span class="antigen-link-icon"> <?xml version="1.0" encoding="utf-8"?>  <svg version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 20 20" style="enable-background:new 0 0 20 20;" xml:space="preserve"> <style type="text/css"> .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;} </style> <g id="Layer_1"> <line class="st0" x1="1.2" y1="2.5" x2="17.6" y2="2.5"/> <path d="M16.4,2.5"/> <g> <path d="M15.4,13.5"/> <path d="M15,14.9l2.8-2.8L15,9.3c0,0,0,0.9,0,1.9h-13V13h13C15.1,14,15.1,14.9,15,14.9z"/> <path d="M4.9,19.3l-2.8-2.8l2.8-2.8c0,0,0,0.9,0,1.9h13v1.8h-13C4.9,18.4,4.9,19.3,4.9,19.3z"/> </g> <g> <path d="M15.4,3.4"/> <path d="M15,6l2.8-2.8L15,0.3c0,0,0,0.9,0,1.9h-13V4h13C15.1,5.1,15.1,5.9,15,6z"/> <path d="M4.9,10.4L2.1,7.6l2.8-2.8c0,0,0,0.9,0,1.9h13v1.8h-13C4.9,9.5,4.9,10.4,4.9,10.4z"/> </g> <g> <path d="M2.8,8.1C1.3,8.1,0,6.9,0,5.4s1.3-2.7,2.8-2.7v1C1.8,3.6,1,4.4,1,5.4s0.8,1.8,1.8,1.8V8.1z"/> </g> <g> <path d="M17.2,12.6c1.5,0,2.8-1.2,2.8-2.8s-1.3-2.8-2.8-2.8v1c1,0,1.8,0.8,1.8,1.8s-0.8,1.8-1.8,1.8V12.6z"/> </g> <g> <path d="M2.8,17.1c-1.5,0-2.8-1.2-2.8-2.8s1.3-2.8,2.8-2.8v1c-1,0-1.8,0.8-1.8,1.8s0.8,1.8,1.8,1.8V17.1z"/> </g> </g> <g id="Layer_1_copy"> <path class="st1" d="M17.4,12.5c1.4-0.1,2.6-1.3,2.6-2.7c0-1.3-0.9-2.4-2.1-2.7V6.7h-13c0-1.1,0-1.9,0-1.9L2.6,7.1 C1.7,7,1,6.3,1,5.4C1,4.6,1.5,4,2.1,3.7V4h13c0,1,0,1.9,0,1.9l2.8-2.8L15,0.3c0,0,0,0.9,0,1.9h-13v0.4C0.9,3,0,4.1,0,5.4 C0,6.8,1.1,8,2.6,8.1l2.3,2.3c0,0,0-0.9,0-1.9h13V8.2C18.5,8.4,19,9.1,19,9.8c0,0.9-0.7,1.7-1.7,1.7L15,9.3c0,0,0,0.9,0,1.9h-13 v0.4C0.9,12,0,13,0,14.3c0,1.5,1.2,2.6,2.6,2.7l2.3,2.3c0,0,0-0.9,0-1.9h13v-1.8h-13c0-1.1,0-1.9,0-1.9L2.6,16 C1.7,15.9,1,15.2,1,14.3c0-0.7,0.5-1.3,1.1-1.6V13h13c0,1,0,1.9,0,1.9L17.4,12.5z"/> </g> </svg> </span> </a> </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Conjugate</h2> </div> <div class="product-item left-flex-cls"> <a ng-if="$ctrl.checkConjugate('Unconjugated ') && ''.trim() != ''" href="" ng-attr-target="{{$ctrl.getRequestCustomLinkTarget()}}" class="conjugate-value">Unconjugated </a> <span ng-if="($ctrl.checkConjugate('Unconjugated ') && ''.trim() == '')" class="conjugate-value">Unconjugated </span> <span ng-if="!$ctrl.checkConjugate('Unconjugated ')" class="conjugate-value">Unconjugated </span> <div class="dropdown conjugate-dropdown"> <button class="btn-link conjugate-btn" type="button" data-toggle="dropdown"> View additional formats <span class="caret"></span> </button> <ul class="dropdown-menu dropdown-menu-fixed"> <li><a class="conjugate-color-padding" href="/antibody/product/MN1020B"> Biotin <span class="conjugate-indicator" style="background-color:"></span> </a></li> <li class="drop-down-link-ctnr"> <a class="conjugate-dropdown-link" href="/us/en/home/global/forms/antibody-conjugates-custom-form.html" ng-attr-target="$ctrl.getRequestCustomLinkTarget()">Request custom conjugation <svg class="svg-icon external-link-icon" ng-if="$ctrl.showExternalLinkIcon()"> <use href="#external-link"></use> </svg> </a> </li> </ul> </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Form</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Liquid </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Concentration</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 0.2 mg/mL </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Purification</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Protein A </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Storage buffer</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> PBS </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Contains</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> no preservative </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Storage conditions</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> -20° C, Avoid Freeze/Thaw Cycles </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Shipping conditions</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Ambient (domestic); Wet ice (international) </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"><h2>RRID <span id="rrid-tooltip" class="rrid-tooltip-icon" ng-include="'/order/genome-database/webapp/assets/core/img/svg/mono_tooltip.svg'" data-toggle="tooltip" ng-click="$ctrl.showRridTooltip()" close-tooltip="$ctrl.closeRridTooltip()" title="Research Resource Identifiers (#RRID) are ID numbers assigned to help researchers cite key resources in the biomedical literature to improve transparency of research methods."> </span></h2> </div> <div class="product-item left-flex-cls">AB_223647</div> </div> </div> <div class="product-specific-details"> <div class="product-specific-details-tbl product-specific-add-border" > <div class="product-info-para"> <h4 class="product-info-para-heading"> Product Specific Information </h4> <p>MN1020 recognizes a phosphatase-senstive epitope on PHF-Tau. No cross reactivity with normal Tau has been observed. The epitope of this antibody contains the phosphorylated Ser202 (4,5) residue (numbering according to human Tau40). <br /><br />MN1020 detects PHF-tau (Ser202/Thr205)a which has a predicted molecular weight of approximately 79 kDa.<br /><br />This product is a Low Endotoxin formulation. <br /><br />Purity is >95% as determined by SDS-PAGE.</p> </div> <div class="product-info-para"> <h4 class="product-info-para-heading"> Target Information </h4> <p class="product-specific-target-info">Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.</p> </div> <p class="product-details-regulatoryStmt">For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.</p> </div> <div class="product-detail-panel-builder"> <tf-promo-ad ng-if="$ctrl.showPromoAd" show-promo-ad="$ctrl.showPromoAd"></tf-promo-ad> </div> </div> </div> </div> </div> <div id="rootPdpDocLoader"></div> <div id="tf-related-products-container" ng-show="emptyRelatedProductsWidget === false" > <related-products-container ng-if="showRelatedProductsWidget === true" base-url="'/api/magellan/related-products-ui/widget/v2/'" product-type="'antibody'" product-sub-type="'primary'" product-id="'MN1020'" country-code="'sg'" iso-language="'en'" > </related-products-container> </div> <div class="tf-pdp-divider" ng-if="emptyRelatedProductsWidget === false" ></div> <div class="references reference-section-3" id="references-component-id"> <div id="references-section-id"> <reference-section ng-if="loadReferences" default-display-card-limit="3" reference-count="911" sub-type="'Antibody'" application-data='{"citationApplications":[{"applicationAbbreviation":"WB","citations":[{"title":"Differences in Tau Seeding in Newborn and Adult Wild-Type Mice.","summary":"MN1020 was used in Western Blotting and Immunohistochemistry to show that (a) differences in tau seeding between newborn and young adults may be related to the ratios between 3Rtau and 4Rtau, and the shift to 4Rtau predominance in adults, together with the immaturity of connections in newborn mice, and (b) intracerebral inoculation of sAD PHFs in newborn mice does not protect from tau seeding following intracerebral inoculation of sAD PHFs in young/adult mice.","authors":"Ferrer I,Andrés-Benito P,Garcia-Esparcia P,López-Gonzalez I,Valiente D,Jordán-Pirla M,Carmona M,Sala-Jarque J,Gil V,Del Rio JA","literatureId":"35563179","journal":"International journal of molecular sciences","volume":"23","publishedDate":"Apr 26, 2022, 4:00:00 AM","url":"http://dx.doi.org/10.3390/ijms23094789","benchSci":false,"imageURL":"https://www.thermofisher.com/antibody/images/250/null?time\u003d20240507","journalAbbr":"Int J Mol Sci","sortOrder":116,"species":["Mouse"],"speciesDilutionMap":{"Mouse":"1:250"},"abbreviationToNameMap":{"IHC":"Immunohistochemistry","WB":"Western Blot"},"newSpeciesDilutionMap":{"Mouse~IHC~1:50":"1:50"}},{"title":"Overexpression of Kinesin Superfamily Motor Proteins in Alzheimer\u0027s Disease.","summary":"MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to conclude that upregulation of KIFs may be an adaptive response to impaired axonal transport in Alzheimer\u0027s disease (AD).","authors":"Hares K,Miners JS,Cook AJ,Rice C,Scolding N,Love S,Wilkins A","literatureId":"29060936","journal":"Journal of Alzheimer\u0027s disease : JAD","volume":"60","pageNumber":"1511","publishedDate":"Jul 23, 2018, 4:00:00 AM","url":"http://dx.doi.org/10.3233/JAD-170094","benchSci":false,"imageURL":"https://www.thermofisher.com/antibody/images/250/null?time\u003d20240507","journalAbbr":"J Alzheimers Dis","sortOrder":419,"species":["Human"],"speciesDilutionMap":{"Human":"1:500"},"abbreviationToNameMap":{"WB":"Western Blot"},"newSpeciesDilutionMap":{"Human~WB~1:500":"1:500"}},{"title":"RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation.","summary":"MN1020 was used in Western Blot to indicate that neuronal NSun2 deficiency promotes dysregulation of miR-125b and tau phosphorylation in AD and highlights a novel avenue for therapeutic targeting.","authors":"Kim YA,Siddiqui T,Blaze J,Cosacak MI,Winters T,Kumar A,Tein E,Sproul AA,Teich AF,Bartolini F,Akbarian S,Kizil C,Hargus G,Santa-Maria I","literatureId":"36357715","journal":"Acta neuropathologica","volume":"145","pageNumber":"29","publishedDate":"Jan 1, 2023, 5:00:00 AM","url":"http://dx.doi.org/10.1007/s00401-022-02511-7","benchSci":false,"imageURL":"https://www.thermofisher.com/antibody/images/250/null?time\u003d20240507","journalAbbr":"Acta Neuropathol","sortOrder":21,"species":["Human"],"speciesDilutionMap":{"Human":"1:500"},"abbreviationToNameMap":{"WB":"Western Blot"},"newSpeciesDilutionMap":{"Human~WB~1:500":"1:500"}}],"citationsCount":280,"speciesList":["Human","Fruit fly","C. elegans","Mouse","Rat","Non-human primate","Cat","Hamster"],"journals":["Life Sci","NPJ Vaccines","Brain","Front Aging Neurosci","Mol Med Rep","Front Cell Neurosci","Methods Mol Biol","Nat Commun","Biochem Biophys Res Commun","Dis Model Mech","Toxicology","Nat Neurosci","Nat Med","Neurobiol Dis","Alzheimers Dement","Am J Pathol","J Am Heart Assoc","Food Chem Toxicol","eNeuro","ACS Chem Neurosci","PLoS One","Neurotherapeutics","Adv Healthc Mater","J Clin Med","J Neurochem","J Neuroinflammation","Nat Struct Mol Biol","J Alzheimers Dis","Sci China Life Sci","Bioact Mater","Anesthesiology","Redox Biol","Neurosci Bull","Elife","PLoS Genet","Neurodegener Dis","Acta Biol Hung","Brain Res","Neurobiol Aging","Hum Mol Genet","J Neurosci","Brain Pathol","Biochim Biophys Acta","Aging Cell","iScience","Nature","Neural Plast","Br J Pharmacol","Front Behav Neurosci","Am J Alzheimers Dis Other Demen","Neural Regen Res","Biol Psychiatry","Neuron","Acta Neuropathol Commun","Proc Natl Acad Sci U S A","Commun Biol","Mol Psychiatry","Sci Adv","Front Cell Dev Biol","J Nutr Biochem","Front Mol Neurosci","Antioxidants (Basel)","Neuroscience","Neurosci Lett","Cell Mol Neurobiol","Exp Brain Res","Genetics","Drug Des Devel Ther","Cell","Alzheimers Res Ther","Ann Neurol","J Cell Sci","Int J Dev Neurosci","NPJ Genom Med","Alzheimers Dement (N Y)","BMC Res Notes","Neuropsychopharmacology","CNS Neurosci Ther","J Neuropathol Exp Neurol","Sci Rep","J Mol Neurosci","Cell Death Differ","Mol Neurobiol","Acta Neuropathol","Mol Cell Neurosci","EMBO J","Int J Mol Sci","Eur J Pharmacol","J Inflamm Res","Vaccines (Basel)","J Neurosci Res","Cell Rep","Biosci Biotechnol Biochem","Cell Death Dis","Molecules","Front Neurol","Clin Transl Med","Neurochem Int","Mol Med","Brain Behav","FEBS Lett","Nat Biomed Eng","Eur J Neurosci","Neurotoxicology","Mol Neurodegener","Mol Brain","Neuropharmacology","FASEB J","Sci Transl Med","Mol Biol Cell","Psychoneuroendocrinology","Front Neuroanat","J Biol Chem"],"speciesMap":{"Human":89,"Fruit fly":4,"C. elegans":1,"Mouse":139,"Rat":22,"Non-human primate":2,"Cat":1,"Hamster":1},"journalsMap":{"Life Sci":1,"NPJ Vaccines":2,"Brain":4,"Front Aging Neurosci":7,"Mol Med Rep":1,"Front Cell Neurosci":3,"Methods Mol Biol":1,"Nat Commun":7,"Biochem Biophys Res Commun":1,"Dis Model Mech":2,"Toxicology":1,"Nat Neurosci":1,"Nat Med":2,"Neurobiol Dis":5,"Alzheimers Dement":2,"Am J Pathol":5,"J Am Heart Assoc":1,"Food Chem Toxicol":1,"eNeuro":1,"ACS Chem Neurosci":2,"PLoS One":10,"Neurotherapeutics":1,"Adv Healthc Mater":1,"J Clin Med":1,"J Neurochem":4,"J Neuroinflammation":3,"Nat Struct Mol Biol":1,"J Alzheimers Dis":14,"Sci China Life Sci":1,"Bioact Mater":1,"Anesthesiology":1,"Redox Biol":1,"Neurosci Bull":1,"Elife":3,"PLoS Genet":1,"Neurodegener Dis":1,"Acta Biol Hung":1,"Brain Res":1,"Neurobiol Aging":14,"Hum Mol Genet":3,"J Neurosci":12,"Brain Pathol":2,"Biochim Biophys Acta":2,"Aging Cell":4,"iScience":3,"Nature":3,"Neural Plast":3,"Br J Pharmacol":1,"Front Behav Neurosci":1,"Am J Alzheimers Dis Other Demen":1,"Neural Regen Res":2,"Biol Psychiatry":1,"Neuron":2,"Acta Neuropathol Commun":4,"Proc Natl Acad Sci U S A":4,"Commun Biol":1,"Mol Psychiatry":4,"Sci Adv":3,"Front Cell Dev Biol":1,"J Nutr Biochem":1,"Front Mol Neurosci":3,"Antioxidants (Basel)":1,"Neuroscience":3,"Neurosci Lett":3,"Cell Mol Neurobiol":1,"Exp Brain Res":1,"Genetics":1,"Drug Des Devel Ther":1,"Cell":1,"Alzheimers Res Ther":2,"Ann Neurol":2,"J Cell Sci":1,"Int J Dev Neurosci":1,"NPJ Genom Med":1,"Alzheimers Dement (N Y)":1,"BMC Res Notes":1,"Neuropsychopharmacology":2,"CNS Neurosci Ther":1,"J Neuropathol Exp Neurol":2,"Sci Rep":9,"J Mol Neurosci":2,"Cell Death Differ":1,"Mol Neurobiol":4,"Acta Neuropathol":5,"Mol Cell Neurosci":1,"EMBO J":2,"Int J Mol Sci":5,"Eur J Pharmacol":1,"J Inflamm Res":1,"Vaccines (Basel)":1,"J Neurosci Res":1,"Cell Rep":4,"Biosci Biotechnol Biochem":1,"Cell Death Dis":4,"Molecules":1,"Front Neurol":1,"Clin Transl Med":1,"Neurochem Int":1,"Mol Med":1,"Brain Behav":1,"FEBS Lett":2,"Nat Biomed Eng":1,"Eur J Neurosci":1,"Neurotoxicology":1,"Mol Neurodegener":7,"Mol Brain":2,"Neuropharmacology":3,"FASEB J":2,"Sci Transl Med":1,"Mol Biol Cell":1,"Psychoneuroendocrinology":1,"Front Neuroanat":1,"J Biol Chem":11},"sortedMap":{}},{"applicationAbbreviation":"IHC","citations":[],"citationsCount":472,"speciesList":["Human","Fruit fly","Mouse","Rat","Non-human primate","Chimpanzee","Rabbit","Dog","Hamster","Pig"],"journals":["NPJ Vaccines","Brain","Mov Disord","Front Aging Neurosci","Arch Pathol Lab Med","Front Cell Neurosci","Methods Mol Biol","Nat Commun","Tremor Other Hyperkinet Mov (N Y)","Brain Res Bull","Invest Ophthalmol Vis Sci","Stem Cells","Nat Neurosci","J Med Chem","Neurobiol Dis","Alzheimers Dement","Exp Neurol","Am J Pathol","J Neural Transm (Vienna)","ACS Chem Neurosci","PLoS One","J Neurosci Methods","Brain Behav Immun","Aging (Albany NY)","J Neurol Neurosurg Psychiatry","J Clin Med","J Neurochem","Neuroimage","J Neuroinflammation","J Alzheimers Dis","Parkinsonism Relat Disord","Forensic Sci Int","J Cereb Blood Flow Metab","Bioact Mater","Neurosci Bull","Redox Biol","Hippocampus","Elife","PLoS Genet","BMC Neurol","Neurodegener Dis","Neuropathology","Brain Res","Neurobiol Aging","Neurol Genet","Hum Mol Genet","J Neurosci","Brain Pathol","Yonsei Med J","Behav Brain Res","Aging Cell","J Comp Pathol","iScience","Nature","Biomed Opt Express","Curr Alzheimer Res","Stroke","Prog Neurobiol","Front Behav Neurosci","J Alzheimers Dis Rep","J Clin Invest","Am J Alzheimers Dis Other Demen","JAMA Psychiatry","J Neurosurg","Biol Psychiatry","Cell Stem Cell","Mol Ther","Neuron","Healthcare (Basel)","Acta Neuropathol Commun","Proc Natl Acad Sci U S A","Neuroimage Clin","Mol Psychiatry","J Anat","Sci Adv","Exp Mol Med","Cell Tissue Res","Front Neurosci","Hum Pathol","Nat Protoc","Front Mol Neurosci","Neuroscience","Int J Alzheimers Dis","Fundam Clin Pharmacol","Int J Mol Med","Neurosci Lett","J Pathol","Geroscience","Br J Anaesth","Lab Invest","Ann Neurol","Alzheimers Res Ther","AIDS","Transl Neurodegener","J Neurovirol","Biometals","Neuropathol Appl Neurobiol","Alzheimers Dement (N Y)","Neurology","Neuropsychopharmacology","CNS Neurosci Ther","J Neuropathol Exp Neurol","Sci Rep","Mol Neurobiol","Acta Neuropathol","Biomedicines","Endocrinology","Transl Psychiatry","EMBO Mol Med","EMBO J","Int J Stroke","Int J Mol Sci","ChemMedChem","EJNMMI Res","J Exp Med","Vaccines (Basel)","J Neurosci Res","Methods Enzymol","Dement Geriatr Cogn Disord","Cell Rep","Cell Death Dis","Molecules","Folia Neuropathol","Front Neurol","J Neural Eng","Eur J Nucl Med Mol Imaging","J Comp Neurol","Brain Dev","Toxicol Pathol","Brain Lang","Brain Behav","Neurobiol Stress","FEBS Lett","Nat Biomed Eng","Eur J Neurosci","Mol Neurodegener","J Neurotrauma","Front Pharmacol","Neuropharmacology","Bioorg Med Chem","Theranostics","FASEB J","Cells","Sci Transl Med","Cell Res","Front Neuroanat","J Biol Chem","Brain Commun","Metab Brain Dis","Acta Biomater","Glia","Aging Dis","J Pathol Clin Res"],"speciesMap":{"Human":271,"Fruit fly":3,"Mouse":161,"Rat":20,"Non-human primate":6,"Chimpanzee":1,"Rabbit":1,"Dog":1,"Hamster":3,"Pig":1},"journalsMap":{"NPJ Vaccines":1,"Brain":13,"Mov Disord":11,"Front Aging Neurosci":11,"Arch Pathol Lab Med":1,"Front Cell Neurosci":1,"Methods Mol Biol":3,"Nat Commun":11,"Tremor Other Hyperkinet Mov (N Y)":1,"Brain Res Bull":1,"Invest Ophthalmol Vis Sci":1,"Stem Cells":1,"Nat Neurosci":1,"J Med Chem":1,"Neurobiol Dis":6,"Alzheimers Dement":2,"Exp Neurol":1,"Am J Pathol":4,"J Neural Transm (Vienna)":4,"ACS Chem Neurosci":1,"PLoS One":21,"J Neurosci Methods":2,"Brain Behav Immun":1,"Aging (Albany NY)":2,"J Neurol Neurosurg Psychiatry":2,"J Clin Med":1,"J Neurochem":2,"Neuroimage":1,"J Neuroinflammation":7,"J Alzheimers Dis":21,"Parkinsonism Relat Disord":5,"Forensic Sci Int":1,"J Cereb Blood Flow Metab":1,"Bioact Mater":2,"Neurosci Bull":1,"Redox Biol":1,"Hippocampus":1,"Elife":1,"PLoS Genet":1,"BMC Neurol":2,"Neurodegener Dis":1,"Neuropathology":6,"Brain Res":6,"Neurobiol Aging":13,"Neurol Genet":1,"Hum Mol Genet":3,"J Neurosci":19,"Brain Pathol":13,"Yonsei Med J":1,"Behav Brain Res":2,"Aging Cell":6,"J Comp Pathol":1,"iScience":2,"Nature":3,"Biomed Opt Express":1,"Curr Alzheimer Res":1,"Stroke":1,"Prog Neurobiol":1,"Front Behav Neurosci":1,"J Alzheimers Dis Rep":1,"J Clin Invest":2,"Am J Alzheimers Dis Other Demen":1,"JAMA Psychiatry":1,"J Neurosurg":1,"Biol Psychiatry":2,"Cell Stem Cell":1,"Mol Ther":2,"Neuron":2,"Healthcare (Basel)":1,"Acta Neuropathol Commun":33,"Proc Natl Acad Sci U S A":2,"Neuroimage Clin":2,"Mol Psychiatry":1,"J Anat":1,"Sci Adv":3,"Exp Mol Med":1,"Cell Tissue Res":1,"Front Neurosci":3,"Hum Pathol":1,"Nat Protoc":1,"Front Mol Neurosci":2,"Neuroscience":3,"Int J Alzheimers Dis":1,"Fundam Clin Pharmacol":1,"Int J Mol Med":1,"Neurosci Lett":1,"J Pathol":1,"Geroscience":1,"Br J Anaesth":1,"Lab Invest":1,"Ann Neurol":6,"Alzheimers Res Ther":2,"AIDS":1,"Transl Neurodegener":1,"J Neurovirol":1,"Biometals":1,"Neuropathol Appl Neurobiol":11,"Alzheimers Dement (N Y)":2,"Neurology":1,"Neuropsychopharmacology":1,"CNS Neurosci Ther":1,"J Neuropathol Exp Neurol":17,"Sci Rep":13,"Mol Neurobiol":1,"Acta Neuropathol":24,"Biomedicines":2,"Endocrinology":1,"Transl Psychiatry":1,"EMBO Mol Med":1,"EMBO J":1,"Int J Stroke":1,"Int J Mol Sci":5,"ChemMedChem":1,"EJNMMI Res":1,"J Exp Med":1,"Vaccines (Basel)":2,"J Neurosci Res":1,"Methods Enzymol":1,"Dement Geriatr Cogn Disord":1,"Cell Rep":3,"Cell Death Dis":3,"Molecules":2,"Folia Neuropathol":1,"Front Neurol":1,"J Neural Eng":1,"Eur J Nucl Med Mol Imaging":2,"J Comp Neurol":2,"Brain Dev":1,"Toxicol Pathol":1,"Brain Lang":1,"Brain Behav":1,"Neurobiol Stress":1,"FEBS Lett":1,"Nat Biomed Eng":1,"Eur J Neurosci":3,"Mol Neurodegener":5,"J Neurotrauma":2,"Front Pharmacol":1,"Neuropharmacology":4,"Bioorg Med Chem":1,"Theranostics":1,"FASEB J":1,"Cells":2,"Sci Transl Med":1,"Cell Res":1,"Front Neuroanat":3,"J Biol Chem":3,"Brain Commun":2,"Metab Brain Dis":1,"Acta Biomater":1,"Glia":3,"Aging Dis":1,"J Pathol Clin Res":1},"sortedMap":{}},{"applicationAbbreviation":"IHC (P)","citations":[],"citationsCount":42,"speciesList":["Human","Mouse","Cat","Dog","Pig"],"journals":["Brain","Neuropathology","Int J Mol Sci","Neurobiol Aging","Lancet Neurol","J Neurosci","Cell Mol Life Sci","Alzheimers Dement","Neurobiol Dis","J Comp Neurol","Aging Cell","Hum Mutat","Cell Rep Med","J Infect Dis","PLoS One","Mol Neurodegener","Neurobiol Learn Mem","Neuropathol Appl Neurobiol","J Neurochem","J Neuroinflammation","Acta Neuropathol Commun","J Alzheimers Dis","J Neuropathol Exp Neurol","Brain Commun","Sci Rep","Acta Neuropathol","Mol Cell Neurosci"],"speciesMap":{"Human":18,"Mouse":8,"Cat":1,"Dog":1,"Pig":1},"journalsMap":{"Brain":3,"Neuropathology":1,"Int J Mol Sci":1,"Neurobiol Aging":2,"Lancet Neurol":1,"J Neurosci":1,"Cell Mol Life Sci":1,"Alzheimers Dement":2,"Neurobiol Dis":1,"J Comp Neurol":2,"Aging Cell":1,"Hum Mutat":1,"Cell Rep Med":1,"J Infect Dis":1,"PLoS One":2,"Mol Neurodegener":2,"Neurobiol Learn Mem":1,"Neuropathol Appl Neurobiol":1,"J Neurochem":1,"J Neuroinflammation":2,"Acta Neuropathol Commun":4,"J Alzheimers Dis":1,"J Neuropathol Exp Neurol":3,"Brain Commun":1,"Sci Rep":1,"Acta Neuropathol":3,"Mol Cell Neurosci":1},"sortedMap":{}},{"applicationAbbreviation":"IHC (F)","citations":[],"citationsCount":9,"speciesList":["Human","Mouse"],"journals":["Cell Death Dis","Nat Aging","J Neuroinflammation","Nucl Med Biol","Acta Neuropathol Commun","J Alzheimers Dis","Sci Rep","Mol Neurobiol","Acta Neuropathol"],"speciesMap":{"Human":4,"Mouse":5},"journalsMap":{"Cell Death Dis":1,"Nat Aging":1,"J Neuroinflammation":1,"Nucl Med Biol":1,"Acta Neuropathol Commun":1,"J Alzheimers Dis":1,"Sci Rep":1,"Mol Neurobiol":1,"Acta Neuropathol":1},"sortedMap":{}},{"applicationAbbreviation":"IHC (Free)","citations":[],"citationsCount":16,"speciesList":["Human","Mouse","Rat"],"journals":["Brain","EMBO J","Front Cell Neurosci","Neurobiol Aging","J Exp Med","Autophagy","FASEB J","Biochim Biophys Acta","J Neurosci","Neuron","Sci Rep","Diabetes","Acta Neuropathol","Exp Neurol"],"speciesMap":{"Human":4,"Mouse":7,"Rat":2},"journalsMap":{"Brain":1,"EMBO J":1,"Front Cell Neurosci":1,"Neurobiol Aging":1,"J Exp Med":1,"Autophagy":1,"FASEB J":1,"Biochim Biophys Acta":1,"J Neurosci":2,"Neuron":1,"Sci Rep":1,"Diabetes":1,"Acta Neuropathol":2,"Exp Neurol":1},"sortedMap":{}},{"applicationAbbreviation":"ICC/IF","citations":[],"citationsCount":53,"speciesList":["Human","Mouse","Rat"],"journals":["Brain","EMBO Mol Med","Front Aging Neurosci","Mol Med Rep","Nat Protoc","Int J Mol Sci","Nat Commun","Front Cell Dev Biol","Neurobiol Aging","Int J Biol Macromol","J Neurosci Res","Autophagy","Hum Mol Genet","Cell Rep","Brain Pathol","J Neurosci","EBioMedicine","Antioxidants (Basel)","Nat Neurosci","Brain Struct Funct","Neurobiol Dis","J Mol Cell Biol","Aging Cell","iScience","PLoS One","J Hypertens","Age (Dordr)","Cell Stem Cell","Cell Res","J Neurochem","J Neuroinflammation","Cell Cycle","J Alzheimers Dis","J Biol Chem","Prion","Sci Rep","Acta Neuropathol","Redox Biol","Transl Psychiatry"],"speciesMap":{"Human":31,"Mouse":18,"Rat":1},"journalsMap":{"Brain":1,"EMBO Mol Med":1,"Front Aging Neurosci":1,"Mol Med Rep":1,"Nat Protoc":1,"Int J Mol Sci":1,"Nat Commun":2,"Front Cell Dev Biol":1,"Neurobiol Aging":1,"Int J Biol Macromol":1,"J Neurosci Res":1,"Autophagy":1,"Hum Mol Genet":1,"Cell Rep":1,"Brain Pathol":2,"J Neurosci":3,"EBioMedicine":1,"Antioxidants (Basel)":1,"Nat Neurosci":2,"Brain Struct Funct":1,"Neurobiol Dis":1,"J Mol Cell Biol":1,"Aging Cell":1,"iScience":1,"PLoS One":3,"J Hypertens":1,"Age (Dordr)":1,"Cell Stem Cell":1,"Cell Res":1,"J Neurochem":1,"J Neuroinflammation":1,"Cell Cycle":1,"J Alzheimers Dis":4,"J Biol Chem":1,"Prion":1,"Sci Rep":1,"Acta Neuropathol":5,"Redox Biol":1,"Transl Psychiatry":1},"sortedMap":{}},{"applicationAbbreviation":"Flow","citations":[],"citationsCount":4,"speciesList":["Human","Yeast"],"journals":["Biotechnol Prog","Neuron","Sci Rep","Am J Pathol"],"speciesMap":{"Human":3,"Yeast":1},"journalsMap":{"Biotechnol Prog":1,"Neuron":1,"Sci Rep":1,"Am J Pathol":1},"sortedMap":{}},{"applicationAbbreviation":"ELISA","citations":[],"citationsCount":8,"speciesList":["Human","Mouse"],"journals":["NPJ Vaccines","J Alzheimers Dis","Mol Neurodegener","Neurobiol Aging","Cell","Am J Pathol"],"speciesMap":{"Human":3,"Mouse":4},"journalsMap":{"NPJ Vaccines":1,"J Alzheimers Dis":2,"Mol Neurodegener":2,"Neurobiol Aging":1,"Cell":1,"Am J Pathol":1},"sortedMap":{}},{"applicationAbbreviation":"IP","citations":[],"citationsCount":2,"speciesList":["Human"],"journals":["Neurobiol Aging","J Biol Chem"],"speciesMap":{"Human":2},"journalsMap":{"Neurobiol Aging":1,"J Biol Chem":1},"sortedMap":{}},{"applicationAbbreviation":"PLA","citations":[],"citationsCount":1,"speciesList":["Human"],"journals":["Sci Rep"],"speciesMap":{"Human":1},"journalsMap":{"Sci Rep":1},"sortedMap":{}},{"applicationAbbreviation":"DB","citations":[],"citationsCount":1,"speciesList":["Human"],"journals":["Sci Adv"],"speciesMap":{"Human":1},"journalsMap":{"Sci Adv":1},"sortedMap":{}},{"applicationAbbreviation":"IA","citations":[],"citationsCount":1,"speciesList":["Mouse"],"journals":["ACS Chem Neurosci"],"speciesMap":{"Mouse":1},"journalsMap":{"ACS Chem Neurosci":1},"sortedMap":{}},{"applicationAbbreviation":"IDF","citations":[],"citationsCount":1,"speciesList":["Mouse"],"journals":["Neural Regen Res"],"speciesMap":{"Mouse":1},"journalsMap":{"Neural Regen Res":1},"sortedMap":{}},{"applicationAbbreviation":"Misc","citations":[],"citationsCount":21,"speciesList":["Human","Fruit fly","Mouse","Rat"],"journals":["Nature","Stem Cell Reports","Nat Protoc","Hum Mol Genet","Neuroscience","J Neuroimmunol","J Neurochem","Acta Neuropathol Commun","J Biol Chem","Neurobiol Dis","Alzheimers Dement","Sci Rep","Neuroreport","Acta Neuropathol"],"speciesMap":{"Human":10,"Fruit fly":1,"Mouse":7,"Rat":3},"journalsMap":{"Nature":1,"Stem Cell Reports":1,"Nat Protoc":1,"Hum Mol Genet":1,"Neuroscience":1,"J Neuroimmunol":1,"J Neurochem":3,"Acta Neuropathol Commun":3,"J Biol Chem":2,"Neurobiol Dis":2,"Alzheimers Dement":1,"Sci Rep":1,"Neuroreport":1,"Acta Neuropathol":2},"sortedMap":{}}]}'></reference-section> </div> <noscript> <div itemscope itemtype="https://schema.org/ScholarlyArticle"> <h2>Product References</h2> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36879821"> <div itemprop="name">Moesin is an effector of tau-induced actin overstabilization, cell cycle activation, and neurotoxicity in Alzheimer's disease.</div> </a> <div itemprop="about">iScience</div> <div itemprop="author">Beckmann A,Ramirez P,Gamez M,Gonzalez E,De Mange J,Bieniek KF,Ray WJ,Frost B</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to identify novel parallels between tauopathy and cancer.</div> <div itemprodp="datePublished">Fri Mar 17 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36936788"> <div itemprop="name">Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline.</div> </a> <div itemprop="about">iScience</div> <div itemprop="author">Jadiya P,Cohen HM,Kolmetzky DW,Kadam AA,Tomar D,Elrod JW</div> <div itemprop="description">MN1020 was used in Western Blotting to demonstrate that loss of NCLX-dependent mCa2+ efflux alone is sufficient to induce an Alzheimer's disease-like pathology and highlights the promise of therapies targeting mCa2+ exchange.</div> <div itemprodp="datePublished">Fri Mar 17 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37353565"> <div itemprop="name">Tau protein binds to the P53 E3 ubiquitin ligase MDM2.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Sola M,Rendon-Angel A,Rojo Martinez V,Sgrignani J,Magrin C,Piovesana E,Cavalli A,Paganetti P,Papin S</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to report the existence in cells and brain of a Tau-MDM2 complex that, in vitro, exhibits reduced P53 ubiquitination activity in a manner sensitive to a Tau mutation.</div> <div itemprodp="datePublished">Fri Jun 23 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37324243"> <div itemprop="name">Spatial characterization of tangle-bearing neurons and ghost tangles in the human inferior temporal gyrus with three-dimensional imaging.</div> </a> <div itemprop="about">Brain communications</div> <div itemprop="author">Zwang TJ,Woost B,Bailey J,Hoglund Z,Richardson DS,Bennett RE,Hyman BT</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to find that ghost tangles are more likely to be found in cortical layers 3 and 5 (49/57), with a select few scattered across other layers 1, 2, 4 and 6.</div> <div itemprodp="datePublished">Sat May 04 00:00:00 EDT 2024</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37580767"> <div itemprop="name">The mitochondrial protein TSPO in Alzheimer's disease: relation to the severity of AD pathology and the neuroinflammatory environment.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Garland EF,Dennett O,Lau LC,Chatelet DS,Bottlaender M,Nicoll JAR,Boche D</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to establish the neuroinflammatory differences between the temporal cortex and cerebellar cortex, including The 18kD translocator protein (TSPO) expression.</div> <div itemprodp="datePublished">Mon Aug 14 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37488165"> <div itemprop="name">Detection, visualization and quantification of protein complexes in human Alzheimer's disease brains using proximity ligation assay.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Romero-Fernandez W,Carvajal-Tapia C,Prusky A,Katdare KA,Wang E,Shostak A,Ventura-Antunes L,Harmsen HJ,Lippmann ES,Fuxe K,MacGurn JA,Borroto-Escuela DO,Schrag MS</div> <div itemprop="description">MN1020 was used in Proximity Ligation Assay (PLA) to refine PLA for use in human neuropathology, which has revealed a profound change in the distribution of ubiquitin in AD brain and its association with characteristic tau pathologies.</div> <div itemprodp="datePublished">Mon Jul 24 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36670973"> <div itemprop="name">Intranasal Administration of KYCCSRK Peptide Rescues Brain Insulin Signaling Activation and Reduces Alzheimer's Disease-like Neuropathology in a Mouse Model for Down Syndrome.</div> </a> <div itemprop="about">Antioxidants (Basel, Switzerland)</div> <div itemprop="author">Tramutola A,Lanzillotta S,Aceto G,Pagnotta S,Ruffolo G,Cifelli P,Marini F,Ripoli C,Palma E,Grassi C,Di Domenico F,Perluigi M,Barone E</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that KYCCSRK rescued insulin signaling activation, increased mitochondrial complexes levels (OXPHOS) and reduced oxidative stress levels in the brain of Ts2Cje mice.</div> <div itemprodp="datePublished">Mon Jan 02 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37166426"> <div itemprop="name">Plasmon-activated water as a therapeutic strategy in Alzheimer's disease by altering gut microbiota.</div> </a> <div itemprop="about">Aging</div> <div itemprop="author">Cheng CH,Liu YC,Yang YSH,Lin KJ,Wu D,Liu YR,Chang CC,Hong CT,Hu CJ</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to show the machinery of gut-brain axis, and plasmon-activated water might be a potential therapeutic strategy in Alzheimer's disease.</div> <div itemprodp="datePublished">Mon May 08 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37463881"> <div itemprop="name">Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Abou-El-Hassan H,Rezende RM,Izzy S,Gabriely G,Yahya T,Tatematsu BK,Habashy KJ,Lopes JR,de Oliveira GLV,Maghzi AH,Yin Z,Cox LM,Krishnan R,Butovsky O,Weiner HL</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to provide new insights on the role of different γδ T cell subsets after brain injury and lay down the principles for the development of targeted γδ T-cell-based therapy for TBI.</div> <div itemprodp="datePublished">Tue Jul 18 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36917493"> <div itemprop="name">Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Cecon E,Oishi A,Luka M,Ndiaye-Lobry D,François A,Lescuyer M,Panayi F,Dam J,Machado P,Jockers R</div> <div itemprop="description">MN1020 was used in Immunohistochemistry and Western Blotting to develop a series of inter- and intramolecular tau biosensors based on the highly sensitive Nanoluciferase (Nluc) binary technology (NanoBiT) able to monitor the pathological conformational change and self-interaction of tau in living cells.</div> <div itemprodp="datePublished">Tue Mar 14 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36917493"> <div itemprop="name">Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Cecon E,Oishi A,Luka M,Ndiaye-Lobry D,François A,Lescuyer M,Panayi F,Dam J,Machado P,Jockers R</div> <div itemprop="description">MN1020 was used in Immunohistochemistry and Western Blotting to develop a series of inter- and intramolecular tau biosensors based on the highly sensitive Nanoluciferase (Nluc) binary technology (NanoBiT) able to monitor the pathological conformational change and self-interaction of tau in living cells.</div> <div itemprodp="datePublished">Tue Mar 14 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36520068"> <div itemprop="name">Intraneuronal tau aggregation induces the integrated stress response in astrocytes.</div> </a> <div itemprop="about">Journal of molecular cell biology</div> <div itemprop="author">Batenburg KL,Kasri NN,Heine VM,Scheper W</div> <div itemprop="description">MN1020 was used in Immunocytochemistry to identify the astrocytic integrated stress response as a novel disease mechanism activated by intraneuronal tau aggregation.</div> <div itemprodp="datePublished">Wed Mar 29 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37167210"> <div itemprop="name">Comparative assessment of regional tau distribution by Tau-PET and Post-mortem neuropathology in a representative set of Alzheimer's & frontotemporal lobar degeneration patients.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Gatto RG,Carlos AF,Reichard RR,Lowe VJ,Whitwell JL,Josephs KA</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to compare regional flortaucipir PET uptake with tau burden using an anti-AT8 antibody.</div> <div itemprodp="datePublished">Mon May 15 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37596279"> <div itemprop="name">A brainstem to circadian system circuit links Tau pathology to sundowning-related disturbances in an Alzheimer's disease mouse model.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Warfield AE,Gupta P,Ruhmann MM,Jeffs QL,Guidone GC,Rhymes HW,Thompson MI,Todd WD</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to examine Alzheimer's disease (AD)-related pathology and circadian dysfunction in the APPSwe-Tau (TAPP) model of AD.</div> <div itemprodp="datePublished">Fri Aug 18 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36738450"> <div itemprop="name">The relationship between hippocampal amyloid beta burden and spatial distribution of neurofibrillary degeneration.</div> </a> <div itemprop="about">Alzheimer's & dementia : the journal of the Alzheimer's Association</div> <div itemprop="author">Walker JM,Goette W,Farrell K,Iida MA,Karlovich E,White CL,Crary JF,Richardson TE</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-paraffin to indicate that the presence and extent of medial temporal lobe Aβ may determine the distribution and spread of neurofibrillary degeneration.</div> <div itemprodp="datePublished">Sat Jul 01 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37533060"> <div itemprop="name">Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Giannini LA,Mol MO,Rajicic A,van Buuren R,Sarkar L,Arezoumandan S,Ohm DT,Irwin DJ,Rozemuller AJ,van Swieten JC,Seelaar H</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to demonstrate that tau pathology and neuronal degeneration are present already at the presymptomatic/early-stage of FTLD-MAPT, though less severely compared to intermediate/end-stage disease.</div> <div itemprodp="datePublished">Wed Aug 02 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36447011"> <div itemprop="name">Discriminative binding of tau PET tracers PI2620, MK6240 and RO948 in Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy brains.</div> </a> <div itemprop="about">Molecular psychiatry</div> <div itemprop="author">Malarte ML,Gillberg PG,Kumar A,Bogdanovic N,Lemoine L,Nordberg A</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate different binding properties among the second-generation tau PET tracers, which may assist in further understanding of tau heterogeneity in AD versus non-AD tauopathies and suggests potential for development of pure selective 4R tau PET tracers.</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37371067"> <div itemprop="name">TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo.</div> </a> <div itemprop="about">Cells</div> <div itemprop="author">Lee-Gosselin A,Jury-Garfe N,You Y,Dabin L,Soni D,Dutta S,Rochet JC,Kim J,Oblak AL,Lasagna-Reeves CA</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate the effects of TREM2 deficiency on tau spreading using a mouse model in which endogenous tau is seeded to produce AD-like tau features.</div> <div itemprodp="datePublished">Sat Jun 10 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37175376"> <div itemprop="name">Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice.</div> </a> <div itemprop="about">Molecules (Basel, Switzerland)</div> <div itemprop="author">Zhong S,Ye J,Deng Y,Zhang M,Zou M,Yao X,Xiao S</div> <div itemprop="description">MN1020 was used in Western Blotting and Immunohistochemsitry to elucidate that quercetagitrin, a natural compound derived from African marigold (Tagetes erecta), could inhibit tau aggregation and reduce tau phosphorylation at multiple disease-related sites in vitro.</div> <div itemprodp="datePublished">Mon May 08 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37175376"> <div itemprop="name">Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice.</div> </a> <div itemprop="about">Molecules (Basel, Switzerland)</div> <div itemprop="author">Zhong S,Ye J,Deng Y,Zhang M,Zou M,Yao X,Xiao S</div> <div itemprop="description">MN1020 was used in Western Blotting and Immunohistochemsitry to elucidate that quercetagitrin, a natural compound derived from African marigold (Tagetes erecta), could inhibit tau aggregation and reduce tau phosphorylation at multiple disease-related sites in vitro.</div> <div itemprodp="datePublished">Mon May 08 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37175376"> <div itemprop="name">Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice.</div> </a> <div itemprop="about">Molecules (Basel, Switzerland)</div> <div itemprop="author">Zhong S,Ye J,Deng Y,Zhang M,Zou M,Yao X,Xiao S</div> <div itemprop="description">MN1020 was used in Western Blotting and Immunohistochemsitry to elucidate that quercetagitrin, a natural compound derived from African marigold (Tagetes erecta), could inhibit tau aggregation and reduce tau phosphorylation at multiple disease-related sites in vitro.</div> <div itemprodp="datePublished">Mon May 08 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37175376"> <div itemprop="name">Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice.</div> </a> <div itemprop="about">Molecules (Basel, Switzerland)</div> <div itemprop="author">Zhong S,Ye J,Deng Y,Zhang M,Zou M,Yao X,Xiao S</div> <div itemprop="description">MN1020 was used in Western Blotting and Immunohistochemsitry to elucidate that quercetagitrin, a natural compound derived from African marigold (Tagetes erecta), could inhibit tau aggregation and reduce tau phosphorylation at multiple disease-related sites in vitro.</div> <div itemprodp="datePublished">Mon May 08 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37014857"> <div itemprop="name">Mutant β<sub>1</sub>-adrenergic receptor improves REM sleep and ameliorates tau accumulation in a mouse model of tauopathy.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Dong Q,Ptáček LJ,Fu YH</div> <div itemprop="description">MN1020 was used in Immunohistochemistry and Western Blotting to test the effect of another familial natural short sleep (FNSS) gene variant, Adrb1-A187V, by crossing mice with this mutation onto the PS19 background.</div> <div itemprodp="datePublished">Tue Apr 11 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37014857"> <div itemprop="name">Mutant β<sub>1</sub>-adrenergic receptor improves REM sleep and ameliorates tau accumulation in a mouse model of tauopathy.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Dong Q,Ptáček LJ,Fu YH</div> <div itemprop="description">MN1020 was used in Immunohistochemistry and Western Blotting to test the effect of another familial natural short sleep (FNSS) gene variant, Adrb1-A187V, by crossing mice with this mutation onto the PS19 background.</div> <div itemprodp="datePublished">Tue Apr 11 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36576708"> <div itemprop="name">The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities.</div> </a> <div itemprop="about">Molecular neurobiology</div> <div itemprop="author">Brandimarti R,Irollo E,Meucci O</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to introduce a new method to limit APP misprocessing and its cellular consequences without directly targeting secretase activity, offering a novel tool to reduce cognitive decline in pathologies such as Alzheimer's disease and HIV-associated neurocognitive disorders.</div> <div itemprodp="datePublished">Sat Apr 01 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36357715"> <div itemprop="name">RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Kim YA,Siddiqui T,Blaze J,Cosacak MI,Winters T,Kumar A,Tein E,Sproul AA,Teich AF,Bartolini F,Akbarian S,Kizil C,Hargus G,Santa-Maria I</div> <div itemprop="description">MN1020 was used in Western Blot to indicate that neuronal NSun2 deficiency promotes dysregulation of miR-125b and tau phosphorylation in AD and highlights a novel avenue for therapeutic targeting.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36732333"> <div itemprop="name">The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Saha I,Yuste-Checa P,Da Silva Padilha M,Guo Q,Körner R,Holthusen H,Trinkaus VA,Dudanova I,Fernández-Busnadiego R,Baumeister W,Sanders DW,Gautam S,Diamond MI,Hartl FU,Hipp MS</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to identify VCP as a core component of the machinery for the removal of neurodegenerative disease aggregates and suggest that its activity can be associated with enhanced aggregate spreading in tauopathies.</div> <div itemprodp="datePublished">Thu Feb 02 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36563857"> <div itemprop="name">Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Park G,Xu K,Chea L,Kim K,Safarta L,Song KH,Wu J,Park S,Min H,Hiramatsu N,Han J,Lin JH</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to identify small-molecule augmentation of protein kinase R-like endoplasmic reticulum kinase signaling as an attractive therapeutic strategy to treat tauopathies by preventing tau pathology.</div> <div itemprodp="datePublished">Wed Feb 01 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37185259"> <div itemprop="name">Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Hussong SA,Banh AQ,Van Skike CE,Dorigatti AO,Hernandez SF,Hart MJ,Ferran B,Makhlouf H,Gaczynska M,Osmulski PA,McAllen SA,Dineley KT,Ungvari Z,Perez VI,Kayed R,Galvan V</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to suggest that soluble pathogenic tau aggregates mediate AD-like brain microvascular deficits in a mouse model of tauopathy, which may arise from endothelial cell senescence and eNOS dysfunction triggered by internalization of soluble tau aggregates.</div> <div itemprodp="datePublished">Tue Apr 25 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36899399"> <div itemprop="name">Ballooned neurons in semi-recent severe traumatic brain injury.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Michaud J,Plu I,Parai J,Bourgault A,Tanguay C,Seilhean D,Woulfe J</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to report the finding of ballooned neurons, predominantly in the anterior cingulum, in three patients who sustained severe TBI and remained comatose until death, 2 ½ weeks to 2 ½ months after the traumatic impact.</div> <div itemprodp="datePublished">Fri Mar 10 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36399262"> <div itemprop="name">Protocol for the Systematic Fixation, Circuit-Based Sampling, and Qualitative and Quantitative Neuropathological Analysis of Human Brain Tissue.</div> </a> <div itemprop="about">Methods in molecular biology (Clifton, N.J.)</div> <div itemprop="author">Latimer CS,Melief EJ,Ariza-Torres J,Howard K,Keen AR,Keene LM,Schantz AM,Sytsma TM,Wilson AM,Grabowski TJ,Darvas M,O'Connor KD,Nolan AL,Edlow BL,Mac Donald CL,Keene CD</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to describe our current protocols for the procurement and characterization of fixed brain tissue, to enable systematic and precisely targeted diagnoses, and describe the novel, quantitative molecular, and neuroanatomical studies that broadly expand the use of formalin-fixed, paraffin-embedded (FFPE) tissue that will further our understanding of the mechanisms underlying human neuropathologies.</div> <div itemprodp="datePublished">Tue Nov 22 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37542184"> <div itemprop="name">Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration.</div> </a> <div itemprop="about">Nature protocols</div> <div itemprop="author">Kang YJ,Diep YN,Tran M,Tran VTA,Ambrin G,Ngo H,Cho H</div> <div itemprop="description">MN1020 was used in Immunocytochemistry-immunofluorescence to show that our human BoCs serve as reliable and valuable platforms to investigate pathological mechanisms involving neuroinflammation and to assess therapeutic strategies modulating neuroinflammation in neurological disorders.</div> <div itemprodp="datePublished">Fri Sep 01 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36598274"> <div itemprop="name">Susceptibility Magnetic Resonance Imaging Correlates with Glial Density and Tau in the Substantia Nigra Pars Compacta.</div> </a> <div itemprop="about">Movement disorders : official journal of the Movement Disorder Society</div> <div itemprop="author">Wang EW,Brown GL,Lewis MM,Jellen LC,Pu C,Johnson ML,Chen H,Kong L,Du G,Huang X</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to test whether susceptibility MRI metrics in parkinsonisms are associated with SNc neuropathologic features of dopaminergic neuron loss, gliosis, and α-synuclein and tau burden.</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37035000"> <div itemprop="name">INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model.</div> </a> <div itemprop="about">iScience</div> <div itemprop="author">Iguchi A,Takatori S,Kimura S,Muneto H,Wang K,Etani H,Ito G,Sato H,Hori Y,Sasaki J,Saito T,Saido TC,Ikezu T,Takai T,Sasaki T,Tomita T</div> <div itemprop="description">MN1020 was used in Western Blotting to suggest that INPP5D acts downstream of TREM2/TYROBP to regulate the microglial barrier against Aβ toxicity, thereby modulates Aβ-dependent pathological conversion of tau.</div> <div itemprodp="datePublished">Fri Apr 21 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36630864"> <div itemprop="name">Microstructural mapping of dentate gyrus pathology in Alzheimer's disease: A 16.4 Tesla MRI study.</div> </a> <div itemprop="about">NeuroImage. Clinical</div> <div itemprop="author">Shih NC,Kurniawan ND,Cabeen RP,Korobkova L,Wong E,Chui HC,Clark KA,Miller CA,Hawes D,Jones KT,Sepehrband F</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to find that quantitative MRI measures were significantly correlated with neurofilament and phosphorylated Tau density, suggesting sensitivity to layer-specific changes in the DG of AD tissues.</div> <div itemprodp="datePublished">Tue Mar 21 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36576642"> <div itemprop="name">Urolithin A reduces amyloid-beta load and improves cognitive deficits uncorrelated with plaque burden in a mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">GeroScience</div> <div itemprop="author">Ballesteros-Álvarez J,Nguyen W,Sivapatham R,Rane A,Andersen JK</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to investigate the effects of urolithin A (UA), a metabolite generated from ellagic acid via its metabolism by gut bacteria, as an autophagy activator with potential neuroprotective activity.</div> <div itemprodp="datePublished">Sat Apr 01 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36226890"> <div itemprop="name">pTDP-43 aggregates accumulate in non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical phenotypic data.</div> </a> <div itemprop="about">The journal of pathology. Clinical research</div> <div itemprop="author">Pattle SB,O'Shaughnessy J,Kantelberg O,Rifai OM,Pate J,Nellany K,Hays N,Arends MJ,Horrocks MH,Waldron FM,Gregory JM</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to identify pTDP-43 aggregates in multiple cell types of the GI tract from archivial surgiacal biposies of ALS patients, implying potential for early ALS diagnosis through the occult proteins.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36759538"> <div itemprop="name">Somatostatin slows Aβ plaque deposition in aged APP<sup>NL-F/NL-F</sup> mice by blocking Aβ aggregation.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Williams D,Yan BQ,Wang H,Negm L,Sackmann C,Verkuyl C,Rezai-Stevens V,Eid S,Vediya N,Sato C,Watts JC,Wille H,Schmitt-Ulms G</div> <div itemprop="description">MN1020 was used in Western Blotting to find that Sst had no influence on whole brain neprilysin transcript, protein or activity levels, an observation that cannot be accounted for by a compensatory upregulation of the Sst paralog, cortistatin (Cort), that we observed in 15-month-old Sst-deficient mice.</div> <div itemprodp="datePublished">Thu Feb 09 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37337279"> <div itemprop="name">Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Williams T,Bathe T,Vo Q,Sacilotto P,McFarland K,Ruiz AJ,Hery GP,Sullivan P,Borchelt DR,Prokop S,Chakrabarty P</div> <div itemprop="description">MN1020 was used in Immunohistochemistry and Western Blotting to indicate that APOE3 genotype may confer some resilience to tauopathy, while APOE4 and APOE2 may act through multiple pathways to increase the pathogenicity in the context of tauopathy.</div> <div itemprodp="datePublished">Mon Jun 19 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37337279"> <div itemprop="name">Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Williams T,Bathe T,Vo Q,Sacilotto P,McFarland K,Ruiz AJ,Hery GP,Sullivan P,Borchelt DR,Prokop S,Chakrabarty P</div> <div itemprop="description">MN1020 was used in Immunohistochemistry and Western Blotting to indicate that APOE3 genotype may confer some resilience to tauopathy, while APOE4 and APOE2 may act through multiple pathways to increase the pathogenicity in the context of tauopathy.</div> <div itemprodp="datePublished">Mon Jun 19 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37337279"> <div itemprop="name">Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Williams T,Bathe T,Vo Q,Sacilotto P,McFarland K,Ruiz AJ,Hery GP,Sullivan P,Borchelt DR,Prokop S,Chakrabarty P</div> <div itemprop="description">MN1020 was used in Immunohistochemistry and Western Blotting to indicate that APOE3 genotype may confer some resilience to tauopathy, while APOE4 and APOE2 may act through multiple pathways to increase the pathogenicity in the context of tauopathy.</div> <div itemprodp="datePublished">Mon Jun 19 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37337279"> <div itemprop="name">Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Williams T,Bathe T,Vo Q,Sacilotto P,McFarland K,Ruiz AJ,Hery GP,Sullivan P,Borchelt DR,Prokop S,Chakrabarty P</div> <div itemprop="description">MN1020 was used in Immunohistochemistry and Western Blotting to indicate that APOE3 genotype may confer some resilience to tauopathy, while APOE4 and APOE2 may act through multiple pathways to increase the pathogenicity in the context of tauopathy.</div> <div itemprodp="datePublished">Mon Jun 19 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34767070"> <div itemprop="name">Diverse human astrocyte and microglial transcriptional responses to Alzheimer's pathology.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Smith AM,Davey K,Tsartsalis S,Khozoie C,Fancy N,Tang SS,Liaptsi E,Weinert M,McGarry A,Muirhead RCJ,Gentleman S,Owen DR,Matthews PM</div> <div itemprop="description">MN1020 was used in Western Blot to define roles that astrocytes and microglia play in Alzheimer's disease (AD) and characterise transcriptomes in astrocyte and microglia nuclei selectively enriched during isolation post-mortem from neuropathologically defined AD and control brains with a range of amyloid-beta and phospho-tau (pTau) pathology.</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35838824"> <div itemprop="name">Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Sepulveda-Falla D,Sanchez JS,Almeida MC,Boassa D,Acosta-Uribe J,Vila-Castelar C,Ramirez-Gomez L,Baena A,Aguillon D,Villalba-Moreno ND,Littau JL,Villegas A,Beach TG,White CL,Ellisman M,Krasemann S,Glatzel M,Johnson KA,Sperling RA,Reiman EM,Arboleda-Velasquez JF,Kosik KS,Lopera F,Quiroz YT</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to describe in vivo follow-up PET imaging and postmortem findings from an autosomal dominant Alzheimer's disease (ADAD) PSEN1 E280A carrier who was also homozygous for the APOE3 Christchurch (APOE3ch) variant and was protected against Alzheimer's symptoms for almost three decades beyond the expected age of onset.</div> <div itemprodp="datePublished">Thu Sep 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35148384"> <div itemprop="name">Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Peris L,Parato J,Qu X,Soleilhac JM,Lanté F,Kumar A,Pero ME,Martínez-Hernández J,Corrao C,Falivelli G,Payet F,Gory-Fauré S,Bosc C,Blanca Ramirez M,Sproul A,Brocard J,Di Cara B,Delagrange P,Buisson A,Goldberg Y,Moutin MJ,Bartolini F,Andrieux A</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to demonstrate that a balanced tyrosination/detyrosination tubulin cycle is necessary for the maintenance of synaptic plasticity, is protective against amyloid β peptide-induced synaptic damage, and that this balance is lost in Alzheimer's disease, providing evidence that defective tubulin retyrosination may contribute to circuit dysfunction during neurodegeneration in Alzheimer's disease.</div> <div itemprodp="datePublished">Fri Jul 29 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35007758"> <div itemprop="name">Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment.</div> </a> <div itemprop="about">Molecular therapy : the journal of the American Society of Gene Therapy</div> <div itemprop="author">Danis C,Dupré E,Zejneli O,Caillierez R,Arrial A,Bégard S,Mortelecque J,Eddarkaoui S,Loyens A,Cantrelle FX,Hanoulle X,Rain JC,Colin M,Buée L,Landrieu I</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to show that VHH Z70, by targeting Tau inside brain neurons, where most of the pathological Tau resides, provides an immunological tool to target the intra-cellular compartment in tauopathies.</div> <div itemprodp="datePublished">Wed Apr 06 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34130857"> <div itemprop="name">Chronic Intermittent Hypoxia Enhances Pathological Tau Seeding, Propagation, and Accumulation and Exacerbates Alzheimer-like Memory and Synaptic Plasticity Deficits and Molecular Signatures.</div> </a> <div itemprop="about">Biological psychiatry</div> <div itemprop="author">Kazim SF,Sharma A,Saroja SR,Seo JH,Larson CS,Ramakrishnan A,Wang M,Blitzer RD,Shen L,Peña CJ,Crary JF,Shimoda LA,Zhang B,Nestler EJ,Pereira AC</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to conclude that CIH-induced increase in pathologic human tau seeding and spread and exacerbation of other AD-related impairments provide new insights into the role of CIH and obstructive sleep apnea in AD pathogenesis.</div> <div itemprodp="datePublished">Tue Feb 15 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35474599"> <div itemprop="name">Amyloid-β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway.</div> </a> <div itemprop="about">Aging cell</div> <div itemprop="author">Jung ES,Suh K,Han J,Kim H,Kang HS,Choi WS,Mook-Jung I</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to suggest that repurposing of FA for inhibiting microglial activation of the NLRP3 inflammasome is a potential treatment for AD.</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35128565"> <div itemprop="name">Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography.</div> </a> <div itemprop="about">European journal of nuclear medicine and molecular imaging</div> <div itemprop="author">Vagenknecht P,Luzgin A,Ono M,Ji B,Higuchi M,Noain D,Maschio CA,Sobek J,Chen Z,Konietzko U,Gerez JA,Riek R,Razansky D,Klohs J,Nitsch RM,Dean-Ben XL,Ni R</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to demonstrate non-invasive whole-brain imaging of tau in P301L mice with vMSOT system using PBB5 at a previously unachieved ~ 115 µm spatial resolution.</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35235058"> <div itemprop="name">Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease.</div> </a> <div itemprop="about">Cellular and molecular life sciences : CMLS</div> <div itemprop="author">Marengo L,Armbrust F,Schoenherr C,Storck SE,Schmitt U,Zampar S,Wirths O,Altmeppen H,Glatzel M,Kaether C,Weggen S,Becker-Pauly C,Pietrzik CU</div> <div itemprop="description">MN1020 was used in Immunohistochemistry (Paraffin) to report the generation of the transgenic APP/lon mouse model of AD lacking the Mep1b gene (APP/lon × Mep1b-/-).</div> <div itemprodp="datePublished">Wed Mar 02 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34822744"> <div itemprop="name">Arterial spin labeling demonstrates preserved regional cerebral blood flow in the P301L mouse model of tauopathy.</div> </a> <div itemprop="about">Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism</div> <div itemprop="author">Kindler D,Maschio C,Ni R,Zerbi V,Razansky D,Klohs J</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate the role of tau in vascular dysfunction.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35178571"> <div itemprop="name">TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans.</div> </a> <div itemprop="about">Disease models & mechanisms</div> <div itemprop="author">Latimer CS,Stair JG,Hincks JC,Currey HN,Bird TD,Keene CD,Kraemer BC,Liachko NF</div> <div itemprop="description">MN1020 was used in Western Blot to study how the synergistic interactions among Aβ, tau, and TDP-43 may be responsible for worsened Alzheimer's disease outcomes.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35966785"> <div itemprop="name">Enriched environment ameliorates propagation of tau pathology and improves cognition in rat model of tauopathy.</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Mate V,Smolek T,Kazmerova ZV,Jadhav S,Brezovakova V,Jurkanin B,Uhrinova I,Basheer N,Zilka N,Katina S,Novak P</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to show that EE seems to be able to slow down tau pathology progression, indicating the possible utility of similar interventions in early stages of AD where tangle loads are still low.</div> <div itemprodp="datePublished">Tue Aug 16 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35978952"> <div itemprop="name">Intraneuronal sortilin aggregation relative to granulovacuolar degeneration, tau pathogenesis and sorfra plaque formation in human hippocampal formation.</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Jiang J,Yang C,Ai JQ,Zhang QL,Cai XL,Tu T,Wan L,Wang XS,Wang H,Pan A,Manavis J,Gai WP,Che C,Tu E,Wang XP,Li ZY,Yan XX</div> <div itemprop="description">MN1020 was used in Immunohistochemistry, Immunocytochemistry to consider intraneuronal sortilin aggregation an aging/stress-related change implicating protein sorting deficit, which can activate protein clearance responses including via enhanced phosphorylation and hydrolysis, thereby promoting GVD, sorfra, and Tau pathogenesis, and ultimately, neuronal destruction and death.</div> <div itemprodp="datePublished">Fri Aug 19 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35978952"> <div itemprop="name">Intraneuronal sortilin aggregation relative to granulovacuolar degeneration, tau pathogenesis and sorfra plaque formation in human hippocampal formation.</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Jiang J,Yang C,Ai JQ,Zhang QL,Cai XL,Tu T,Wan L,Wang XS,Wang H,Pan A,Manavis J,Gai WP,Che C,Tu E,Wang XP,Li ZY,Yan XX</div> <div itemprop="description">MN1020 was used in Immunohistochemistry, Immunocytochemistry to consider intraneuronal sortilin aggregation an aging/stress-related change implicating protein sorting deficit, which can activate protein clearance responses including via enhanced phosphorylation and hydrolysis, thereby promoting GVD, sorfra, and Tau pathogenesis, and ultimately, neuronal destruction and death.</div> <div itemprodp="datePublished">Fri Aug 19 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35847683"> <div itemprop="name">Patient-Derived Fibroblasts With Presenilin-1 Mutations, That Model Aspects of Alzheimer's Disease Pathology, Constitute a Potential Object for Early Diagnosis.</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Lopez-Toledo G,Silva-Lucero MD,Herrera-Díaz J,García DE,Arias-Montaño JA,Cardenas-Aguayo MD</div> <div itemprop="description">MN1020 was used in Western Blotting to indicate that fibroblasts from patients with FAD-PS1 present alterations in signaling pathways related to cellular stress, autophagy, lysosomes, and tau phosphorylation.</div> <div itemprodp="datePublished">Tue Jul 19 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35031916"> <div itemprop="name">Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer's Disease.</div> </a> <div itemprop="about">Molecular neurobiology</div> <div itemprop="author">Fagan SG,Bechet S,Dev KK</div> <div itemprop="description">MN1020 was used in Western Blot to investigate the action of the disease-modifying oral neuroimmunomodulatory therapeutic used in patients with multiple sclerosis, fingolimod, in the triple transgenic 3xTg-AD mouse model of Alzheimer's disease.</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35831558"> <div itemprop="name">Long-Term Sequelae of COVID-19 in Experimental Mice.</div> </a> <div itemprop="about">Molecular neurobiology</div> <div itemprop="author">Paidas MJ,Cosio DS,Ali S,Kenyon NS,Jayakumar AR</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to suggest that COVID-19 may result in long-term, irreversible changes predominantly in the brain, lung, and heart.</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34897095"> <div itemprop="name">Borrelia burgdorferi Co-Localizing with Amyloid Markers in Alzheimer's Disease Brain Tissues.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Senejani AG,Maghsoudlou J,El-Zohiry D,Gaur G,Wawrzeniak K,Caravaglia C,Khatri VA,MacDonald A,Sapi E</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to provide evidence for a likely association between B. burgdorferi infections and biofilm formation, AD pathology, and chronic neurodegenerative diseases.</div> <div itemprodp="datePublished">Mon Feb 28 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34897095"> <div itemprop="name">Borrelia burgdorferi Co-Localizing with Amyloid Markers in Alzheimer's Disease Brain Tissues.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Senejani AG,Maghsoudlou J,El-Zohiry D,Gaur G,Wawrzeniak K,Caravaglia C,Khatri VA,MacDonald A,Sapi E</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to provide evidence for a likely association between B. burgdorferi infections and biofilm formation, AD pathology, and chronic neurodegenerative diseases.</div> <div itemprodp="datePublished">Mon Feb 28 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34977433"> <div itemprop="name">Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer's disease.</div> </a> <div itemprop="about">Bioactive materials</div> <div itemprop="author">Xu S,Yang P,Qian K,Li Y,Guo Q,Wang P,Meng R,Wu J,Cao J,Cheng Y,Xu M,Zhang Q</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to demonstrate a promising strategy to restore autophagic flux and improve neuronal proteostasis by rationally-engineered nano-systems for delaying the progression of AD.</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34977433"> <div itemprop="name">Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer's disease.</div> </a> <div itemprop="about">Bioactive materials</div> <div itemprop="author">Xu S,Yang P,Qian K,Li Y,Guo Q,Wang P,Meng R,Wu J,Cao J,Cheng Y,Xu M,Zhang Q</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to demonstrate a promising strategy to restore autophagic flux and improve neuronal proteostasis by rationally-engineered nano-systems for delaying the progression of AD.</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35910789"> <div itemprop="name">A surrogate marker for very early-stage tau pathology is detectable by molecular magnetic resonance imaging.</div> </a> <div itemprop="about">Theranostics</div> <div itemprop="author">Parekh P,Mu Q,Badachhape A,Bhavane R,Srivastava M,Devkota L,Sun X,Bhandari P,Eriksen JL,Tanifum E,Ghaghada K,Annapragada A</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to hypothesize that hyperphosphorylative conditions may result in unique cell surface markers.</div> <div itemprodp="datePublished">Tue Aug 02 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36361662"> <div itemprop="name">Pathological Nuclear Hallmarks in Dentate Granule Cells of Alzheimer's Patients: A Biphasic Regulation of Neurogenesis.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Gil L,Chi-Ahumada E,Niño SA,Capdeville G,Méndez-Torres AM,Guerrero C,Rebolledo AB,Olazabal IM,Jiménez-Capdeville ME</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to find nuclear alterations in granular cells in autopsied human brains, detected by immunohistochemistry.</div> <div itemprodp="datePublished">Tue Oct 25 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35687573"> <div itemprop="name">Alpha-synuclein and tau are abundantly expressed in the ENS of the human appendix and monkey cecum.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Zinnen AD,Vichich J,Metzger JM,Gambardella JC,Bondarenko V,Simmons HA,Emborg ME</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to provide critical translational evidence that the common marmoset and rhesus macaque ceca are remarkably similar to the human appendix and, thus, that these NHP species are suitable for studying the development of PD linked to α-syn and tau pathological changes in the ENS.</div> <div itemprodp="datePublished">Tue Jun 14 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36187086"> <div itemprop="name">Synthesis and Bioactivity Evaluation of a Novel 1,2,4-Oxadiazole Derivative in vitro and in 3×Tg Mice.</div> </a> <div itemprop="about">Drug design, development and therapy</div> <div itemprop="author">Luo Z,Wang Y,Pang S,Gao S,Liu N,Gao X,Zhang L,Qi X,Yang Y,Zhang L</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate wyc-7-20 was potent in AD therapy.</div> <div itemprodp="datePublished">Tue Oct 04 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35659876"> <div itemprop="name">Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons.</div> </a> <div itemprop="about">Cell stem cell</div> <div itemprop="author">Capano LS,Sato C,Ficulle E,Yu A,Horie K,Kwon JS,Burbach KF,Barthélemy NR,Fox SG,Karch CM,Bateman RJ,Houlden H,Morimoto RI,Holtzman DM,Duff KE,Yoo AS</div> <div itemprop="description">MN1020 was used in Immunocytochemistry to demonstrate the utility of miRNA-induced neuronal reprogramming to recapitulate endogenous tau regulation comparable with the adult brain in health and disease.</div> <div itemprodp="datePublished">Thu Jun 02 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35903039"> <div itemprop="name">Tau Pathology in Chronic Traumatic Encephalopathy is Primarily Neuronal.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Butler MLMD,Dixon E,Stein TD,Alvarez VE,Huber B,Buckland ME,McKee AC,Cherry JD</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to support neuronal degeneration as a driving feature of CTE and will help inform future research and the development of fluid biomarkers for the detection of neuronal degeneration in CTE.</div> <div itemprodp="datePublished">Mon Sep 19 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36114722"> <div itemprop="name">Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation.</div> </a> <div itemprop="about">CNS neuroscience & therapeutics</div> <div itemprop="author">Li L,Miao J,Chu D,Jin N,Tung YC,Dai CL,Hu W,Gong CX,Iqbal K,Liu F</div> <div itemprop="description">MN1020 was used in Immunohistochemistry and Western Blotting to indicate that 77G7 can effectively suppress the seeding activity of AD O-tau and thus could be developed as a potential immunotherapeutic drug to inhibit the propagation of tau pathology in AD and related tauopathies.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36114722"> <div itemprop="name">Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation.</div> </a> <div itemprop="about">CNS neuroscience & therapeutics</div> <div itemprop="author">Li L,Miao J,Chu D,Jin N,Tung YC,Dai CL,Hu W,Gong CX,Iqbal K,Liu F</div> <div itemprop="description">MN1020 was used in Immunohistochemistry and Western Blotting to indicate that 77G7 can effectively suppress the seeding activity of AD O-tau and thus could be developed as a potential immunotherapeutic drug to inhibit the propagation of tau pathology in AD and related tauopathies.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35534858"> <div itemprop="name">Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Taddei RN,Sanchez-Mico MV,Bonnar O,Connors T,Gaona A,Denbow D,Frosch MP,Gómez-Isla T</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to suggest that changes in glial phenotypes in cortical and subcortical regions represent an early phenomenon that precedes overt tau deposition and likely contributes to cell damage and loss of brain function predicting the cognitive status of individuals at intermediate stages of tau aggregate burden (Braak III-IV).</div> <div itemprodp="datePublished">Mon May 09 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35718229"> <div itemprop="name">Mice expressing P301S mutant human tau have deficits in interval timing.</div> </a> <div itemprop="about">Behavioural brain research</div> <div itemprop="author">Larson T,Khandelwal V,Weber MA,Leidinger MR,Meyerholz DK,Narayanan NS,Zhang Q</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to evaluate interval timing performance of P301S transgenic mice, a widely studied model of tauopathy that overexpresses human tau with the P301S mutation.</div> <div itemprodp="datePublished">Fri Aug 26 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35373453"> <div itemprop="name">Independent distribution between tauopathy secondary to subacute sclerotic panencephalitis and measles virus: An immunohistochemical analysis in autopsy cases including cases treated with aggressive antiviral therapies.</div> </a> <div itemprop="about">Brain pathology (Zurich, Switzerland)</div> <div itemprop="author">Miyahara H,Akagi A,Riku Y,Sone J,Otsuka Y,Sakai M,Kuru S,Hasegawa M,Yoshida M,Kakita A,Iwasaki Y</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate the efficacy of antiviral therapies on Subacute sclerotic panencephalitis patients.</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35804072"> <div itemprop="name">Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Suzuki C,Yamaguchi J,Sanada T,Oliva Trejo JA,Kakuta S,Shibata M,Tanida I,Uchiyama Y</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to propose thatt the CtsD-CKO mouse is a useful mouse model to investigate the contribution of cathepsin D to the early phases of neurodegenerative diseases in relation to lipofuscins, proteinopathy-related proteins and activation of microglia and astrocytes.</div> <div itemprodp="datePublished">Fri Jul 08 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36435806"> <div itemprop="name">Repetitive mild TBI causes pTau aggregation in nigra without altering preexisting fibril induced Parkinson's-like pathology burden.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Delic V,Karp JH,Guzman M,Arismendi GR,Stalnaker KJ,Burton JA,Murray KE,Stamos JP,Beck KD,Sokratian A,West AB,Citron BA</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that r-mTBI induced pTau aggregate deposition in dopaminergic neurons may create an environment conducive to αSyn pathology nucleation and may add to preexisting proteinaceous aggregate burden.</div> <div itemprodp="datePublished">Sat Nov 26 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35017447"> <div itemprop="name">Crry silencing alleviates Alzheimer's disease injury by regulating neuroinflammatory cytokines and the complement system.</div> </a> <div itemprop="about">Neural regeneration research</div> <div itemprop="author">Zhu XC,Liu L,Dai WZ,Ma T</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that Crry silencing in the P301S mouse model reduces tau protein phosphorylation by reducing the levels of neuroinflammation and complement components, thereby improving cognitive function.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35017447"> <div itemprop="name">Crry silencing alleviates Alzheimer's disease injury by regulating neuroinflammatory cytokines and the complement system.</div> </a> <div itemprop="about">Neural regeneration research</div> <div itemprop="author">Zhu XC,Liu L,Dai WZ,Ma T</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that Crry silencing in the P301S mouse model reduces tau protein phosphorylation by reducing the levels of neuroinflammation and complement components, thereby improving cognitive function.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36271092"> <div itemprop="name">Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Rickner HD,Jiang L,Hong R,O'Neill NK,Mojica CA,Snyder BJ,Zhang L,Shaw D,Medalla M,Wolozin B,Cheng CS</div> <div itemprop="description">MN1020 was used in Simple Western - Size to conclude that treatment with the HSP90 inhibitor PU-H71 is used to address the putative dysfunctional HSP chaperone system and produces a strong reduction of pathology and neurodegeneration, highlighting the potential of AstTau as a rapid and reproducible tool for drug discovery.</div> <div itemprodp="datePublished">Fri Oct 21 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36271092"> <div itemprop="name">Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Rickner HD,Jiang L,Hong R,O'Neill NK,Mojica CA,Snyder BJ,Zhang L,Shaw D,Medalla M,Wolozin B,Cheng CS</div> <div itemprop="description">MN1020 was used in Simple Western - Size to conclude that treatment with the HSP90 inhibitor PU-H71 is used to address the putative dysfunctional HSP chaperone system and produces a strong reduction of pathology and neurodegeneration, highlighting the potential of AstTau as a rapid and reproducible tool for drug discovery.</div> <div itemprodp="datePublished">Fri Oct 21 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35638570"> <div itemprop="name">HIV and FIV glycoproteins increase cellular tau pathology via cGMP-dependent kinase II activation.</div> </a> <div itemprop="about">Journal of cell science</div> <div itemprop="author">Sathler MF,Doolittle MJ,Cockrell JA,Nadalin IR,Hofmann F,VandeWoude S,Kim S</div> <div itemprop="description">MN1020 was used in Western Blotting to reveal that viral glycoprotein-induced cellular tau pathology requires cGKII activation.</div> <div itemprodp="datePublished">Wed Jun 15 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34938923"> <div itemprop="name">Three-dimensional-engineered bioprinted <i>in vitro</i> human neural stem cell self-assembling culture model constructs of Alzheimer's disease.</div> </a> <div itemprop="about">Bioactive materials</div> <div itemprop="author">Zhang Y,Chen H,Long X,Xu T</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to develop 3D core-shell Alzheimer's disease model to investigate pathogenic cascade of Alzheimer's disease (AD) characterized by amyloid-β protein accumulation.</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35150166"> <div itemprop="name">Association of Retromer Deficiency and Tau Pathology in Down Syndrome.</div> </a> <div itemprop="about">Annals of neurology</div> <div itemprop="author">Curtis ME,Smith T,Yu D,Praticò D</div> <div itemprop="description">MN1020 was used in Western Blotting to investigate retromer deficiency in Down syndrome.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35218773"> <div itemprop="name">Unbiased proteomic profiling reveals the IP3R modulator AHCYL1/IRBIT as a novel interactor of microtubule-associated protein tau.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Wischhof L,Adhikari A,Mondal M,Marsal-Cots A,Biernat J,Mandelkow EM,Mandelkow E,Ehninger D,Nicotera P,Bano D</div> <div itemprop="description">MN1020 was used in Immunoprecipitation, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to indicate that tau interacts with AHCYL1/IRBIT and potentially modulates AHCYL1/IRBIT function.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35164877"> <div itemprop="name">Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Walker JM,Kazempour Dehkordi S,Fracassi A,Vanschoiack A,Pavenko A,Taglialatela G,Woltjer R,Richardson TE,Zare H,Orr ME</div> <div itemprop="description">MN1020 was used in Immunohistochemistry (Paraffin) to investigate the protein expression differences comparing individuals with dementia and Alzheimer disease neuropathologic change to resilient individuals, using NanoString GeoMx™ Digital Spatial Profiler (DSP) technology.</div> <div itemprodp="datePublished">Mon Feb 14 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35109872"> <div itemprop="name">Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer's disease.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Muñoz-Castro C,Noori A,Magdamo CG,Li Z,Marks JD,Frosch MP,Das S,Hyman BT,Serrano-Pozo A</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to enable a comprehensive morphological quantitative characterization of astrocytes and microglia in the context of their spatial relationships with plaques and tangles.</div> <div itemprodp="datePublished">Wed Feb 02 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35045380"> <div itemprop="name">Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Dahl MJ,Mather M,Werkle-Bergner M,Kennedy BL,Guzman S,Hurth K,Miller CA,Qiao Y,Shi Y,Chui HC,Ringman JM</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to find lower rostral locus coeruleus integrity in symptomatic participants.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36066634"> <div itemprop="name">Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Giannini LAA,Ohm DT,Rozemuller AJM,Dratch L,Suh E,van Deerlin VM,Trojanowski JQ,Lee EB,van Swieten JC,Grossman M,Seelaar H,Irwin DJ</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study grey matter tau burden, its relation to neuronal degeneration, and regional patterns of pathology in different isoform groups of FTLD-MAPT.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35526514"> <div itemprop="name">Cognitive resilience to three dementia-related neuropathologies in an oldest-old man: A case report from The 90+ Study.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Melikyan ZA,Corrada MM,Leiby AM,Sajjadi SA,Bukhari S,Montine TJ,Kawas CH</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to describe the only participant of The 90+ Study, among 367 autopsies, who maintained normal cognition despite intermediate-high levels of 3 dementia-related neuropathologic changes, advanced age, and comorbidities associated with cognitive impairment.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36056435"> <div itemprop="name">Trem2 deletion enhances tau dispersion and pathology through microglia exosomes.</div> </a> <div itemprop="about">Molecular neurodegeneration</div> <div itemprop="author">Zhu B,Liu Y,Hwang S,Archuleta K,Huang H,Campos A,Murad R,Piña-Crespo J,Xu H,Huang TY</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to reveal a role for Trem2 in suppressing exosomal tau pathogenicity, and demonstrates that Trem2 deletion can enhance tau trafficking, distribution and seeding through microglial exosomes.</div> <div itemprodp="datePublished">Fri Sep 02 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34048087"> <div itemprop="name">Lifelong chronic psychosocial stress induces a proteomic signature of Alzheimer's disease in wildtype mice.</div> </a> <div itemprop="about">The European journal of neuroscience</div> <div itemprop="author">Lyons CE,Zhou X,Razzoli M,Chen M,Xia W,Ashe K,Zhang B,Bartolomucci A</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to compare the differentially expressed proteins (DEPs) of subordinate mice to those of patients at varying stages of dementia.</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34048087"> <div itemprop="name">Lifelong chronic psychosocial stress induces a proteomic signature of Alzheimer's disease in wildtype mice.</div> </a> <div itemprop="about">The European journal of neuroscience</div> <div itemprop="author">Lyons CE,Zhou X,Razzoli M,Chen M,Xia W,Ashe K,Zhang B,Bartolomucci A</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to compare the differentially expressed proteins (DEPs) of subordinate mice to those of patients at varying stages of dementia.</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35508385"> <div itemprop="name">Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Steuer EL,Kemper LJ,Hlynialuk CJW,Leinonen-Wright K,Montonye ML,Lapcinski IP,Forster CL,Ashe KH,Liu P</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that htau transgene expression occurs primarily in the forebrain at similar levels in rT2 and rT3 mice.</div> <div itemprodp="datePublished">Wed Jun 08 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36099918"> <div itemprop="name">A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency.</div> </a> <div itemprop="about">Cell reports. Medicine</div> <div itemprop="author">Andersen OM,Bøgh N,Landau AM,Pløen GG,Jensen AMG,Monti G,Ulhøi BP,Nyengaard JR,Jacobsen KR,Jørgensen MM,Holm IE,Kristensen ML,Alstrup AKO,Hansen ESS,Teunissen CE,Breidenbach L,Droescher M,Liu Y,Pedersen HS,Callesen H,Luo Y,Bolund L,Brooks DJ,Laustsen C,Small SA,Mikkelsen LF,Sørensen CB</div> <div itemprop="description">MN1020 was used in Immunohistochemistry (Paraffin) to provide functional support for the theory that SORL1 haploinsufficiency leads to endosome cytopathology with biofluid hallmarks of autosomal dominant AD.</div> <div itemprodp="datePublished">Tue Sep 20 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35690868"> <div itemprop="name">Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.</div> </a> <div itemprop="about">Molecular neurodegeneration</div> <div itemprop="author">Xia D,Lianoglou S,Sandmann T,Calvert M,Suh JH,Thomsen E,Dugas J,Pizzo ME,DeVos SL,Earr TK,Lin CC,Davis S,Ha C,Leung AW,Nguyen H,Chau R,Yulyaningsih E,Lopez I,Solanoy H,Masoud ST,Liang CC,Lin K,Astarita G,Khoury N,Zuchero JY,Thorne RG,Shen K,Miller S,Palop JJ,Garceau D,Sasner M,Whitesell JD,Harris JA,Hummel S,Gnörich J,Wind K,Kunze L,Zatcepin A,Brendel M,Willem M,Haass C,Barnett D,Zimmer TS,Orr AG,Scearce-Levie K,Lewcock JW,Di Paolo G,Sanchez PE</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to demonstrate that fibrillar Aβ in microglia is associated with lipid dyshomeostasis consistent with lysosomal dysfunction and foam cell phenotypes as well as profound immuno-metabolic perturbations, opening new avenues to further investigate metabolic pathways at play in microglia responding to AD-relevant pathogenesis.</div> <div itemprodp="datePublished">Sat Jun 11 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35579705"> <div itemprop="name">Evidence of traumatic brain injury in headbutting bovids.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Ackermans NL,Varghese M,Williams TM,Grimaldi N,Selmanovic E,Alipour A,Balchandani P,Reidenberg JS,Hof PR</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to indicate that muskoxen and possibly other headbutting bovids suffer from chronic or acute brain trauma and that the males' thicker skulls may protect them to a certain extent.</div> <div itemprodp="datePublished">Fri Jul 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35072001"> <div itemprop="name">Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model.</div> </a> <div itemprop="about">iScience</div> <div itemprop="author">Manos JD,Preiss CN,Venkat N,Tamm J,Reinhardt P,Kwon T,Wu J,Winter AD,Jahn TR,Yanamandra K,Titterton K,Karran E,Langlois X</div> <div itemprop="description">MN1020 was used in Immunocytochemistry to define the minimal requirements to achieve endogenous tau aggregation in functional neurons utilizing human induced pluripotent stem cell (hiPSC) technology.</div> <div itemprodp="datePublished">Fri Jan 21 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35941704"> <div itemprop="name">Corpora amylacea are associated with tau burden and cognitive status in Alzheimer's disease.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Wander CM,Tsujimoto THM,Ervin JF,Wang C,Maranto SM,Bhat V,Dallmeier JD,Wang SJ,Lin FC,Scott WK,Holtzman DM,Cohen TJ</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate the link between Corpora amylacea and age-related neurodegenerative diseases, particularly Alzheimer's disease (AD).</div> <div itemprodp="datePublished">Mon Aug 08 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35905044"> <div itemprop="name">Mutations in SORL1 and MTHFDL1 possibly contribute to the development of Alzheimer's disease in a multigenerational Colombian Family.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Tejada Moreno JA,Villegas Lanau A,Madrigal Zapata L,Baena Pineda AY,Velez Hernandez J,Campo Nieto O,Soto Ospina A,Araque Marín P,Rishishwar L,Norris ET,Chande AT,Jordan IK,Bedoya Berrio G</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to evaluate a family of 97 members, spanning three generations, with a familiar AD, and without mutations in APP, PSEN1, or PSEN2.</div> <div itemprodp="datePublished">Mon Nov 20 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35904470"> <div itemprop="name">Tau protein is differentially phosphorylated in young- and old-aged rats with experimentally induced hyperthyroidism.</div> </a> <div itemprop="about">International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience</div> <div itemprop="author">Tan B,Babur E,Toy N,Günaydın B,Dursun N,Süer C</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to study long-term potentiation (LTP) and accompanying phosphorylation of Tau protein in different residues in the hippocampus of young and old rats with experimentally induced hyperthyroidism.</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36539803"> <div itemprop="name">Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Manet C,Mansuroglu Z,Conquet L,Bortolin V,Comptdaer T,Segrt H,Bourdon M,Menidjel R,Stadler N,Tian G,Herit F,Niedergang F,Souès S,Buée L,Galas MC,Montagutelli X,Bonnefoy E</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that ZIKV-infected mature neurons display an inability to stop viral replication in link with a delayed IFNB expression, accumulating pTau and overall reflecting tauopathy-like phenotype.</div> <div itemprodp="datePublished">Tue Dec 20 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35332321"> <div itemprop="name">Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation.</div> </a> <div itemprop="about">Nature structural & molecular biology</div> <div itemprop="author">Kang SS,Meng L,Zhang X,Wu Z,Mancieri A,Xie B,Liu X,Weinshenker D,Peng J,Zhang Z,Ye K</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that DOPEGAL, a monoamine oxidase A (MAO-A) metabolite of norepinephrine (NE), reacts directly with the primary amine on the Lys353 residue of tau to stimulate its aggregation and facilitate its propagation.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34100451"> <div itemprop="name">Neural stem cell transplantation alleviates functional cognitive deficits in a mouse model of tauopathy.</div> </a> <div itemprop="about">Neural regeneration research</div> <div itemprop="author">Zhang HA,Yuan CX,Liu KF,Yang QF,Zhao J,Li H,Yang QH,Song D,Quan ZZ,Qing H</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to reveal that NSC transplantation reduced the abnormal aggregation of tau, resulting in significant improvements in the short-term memory of the tauopathy model mice.</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35237315"> <div itemprop="name">Preferential Involvement of BRCA1/BARD1, Not Tip60/Fe65, in DNA Double-Strand Break Repair in Presenilin-1 P117L Alzheimer Models.</div> </a> <div itemprop="about">Neural plasticity</div> <div itemprop="author">Authiat MM,Gruz-Gibelli E,Colas J,Bianchi E,Garcia-Arauzo M,Marin P,Herrmann FR,Savioz A</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to investigate DSBs in cells and murine models of Alzheimer's disease carrying the preseniline-1 (PS1) P117L mutation and suggest that at earlier stages of the disease, similarly to PS1 P117L cells, a compensatory mechanism exists that decreases DSB levels via an activation of the BRCA1/BARD1 pathway.</div> <div itemprodp="datePublished">Thu Apr 07 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36274955"> <div itemprop="name">Altered low-frequency brain rhythms precede changes in gamma power during tauopathy.</div> </a> <div itemprop="about">iScience</div> <div itemprop="author">Rodrigues FR,Papanikolaou A,Holeniewska J,Phillips KG,Saleem AB,Solomon SG</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to study how brain rhythms are affected in rTg4510 mouse model of tauopathy, at an early stage of tauopathy (5 months), and at a more advanced stage (8 months).</div> <div itemprodp="datePublished">Fri Oct 21 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35551470"> <div itemprop="name">Neuropathological associations of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) differ between the oldest-old and younger-old.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Wang SJ,Guo Y,Ervin JF,Lusk JB,Luo S</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to compare the neuropathological associations of LATE-NC and contribution of LATE-NC to cognitive impairment between the oldest-old and younger-old.</div> <div itemprodp="datePublished">Fri Jul 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36004533"> <div itemprop="name">Differential Vulnerability of Hippocampal Subfields in Primary Age-Related Tauopathy and Chronic Traumatic Encephalopathy.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Farrell K,Iida MA,Cherry JD,Casella A,Stein TD,Bieniek KF,Walker JM,Richardson TE,White CL,Alvarez VE,Huber BR,Dickson DW,Insausti R,Dams-O'Connor K,McKee AC,Crary JF</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to demonstrate differences in hippocampal p-tau burden and regional distribution in CTE compared to PART that might be helpful in differential diagnosis and reveal insights into disease pathogenesis.</div> <div itemprodp="datePublished">Mon Sep 19 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35327482"> <div itemprop="name">Biomarkers Analysis and Clinical Manifestations in Comorbid Creutzfeldt-Jakob Disease: A Retrospective Study in 215 Autopsy Cases.</div> </a> <div itemprop="about">Biomedicines</div> <div itemprop="author">Jankovska N,Rusina R,Keller J,Kukal J,Bruzova M,Parobkova E,Olejar T,Matej R</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to conclude that comorbid neuropathologies can impact disease manifestation and can complicate the clinical diagnosis of Creutzfeldt-Jakob disease (CJD).</div> <div itemprodp="datePublished">Wed Mar 16 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35882228"> <div itemprop="name">Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer's disease.</div> </a> <div itemprop="about">Neuron</div> <div itemprop="author">Otero-Garcia M,Mahajani SU,Wakhloo D,Tang W,Xue YQ,Morabito S,Pan J,Oberhauser J,Madira AE,Shakouri T,Deng Y,Allison T,He Z,Lowry WE,Kawaguchi R,Swarup V,Cobos I</div> <div itemprop="description">MN1020 was used in Flow Cytometry to demonstrate methods for the high-throughput isolation and transcriptome profiling of single somas with NFTs from the human Alzheimer's disease (AD) brain, quantify the susceptibility of 20 neocortical subtypes for NFT formation and death, and identify both shared and cell-type-specific signatures.</div> <div itemprodp="datePublished">Wed Sep 21 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35871344"> <div itemprop="name">Long-Term Depression-Inducing Low Frequency Stimulation Enhances p-Tau181 and p-Tau217 in an Age-Dependent Manner in Live Rats.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Zhang Y,Yang Y,Hu Z,Zhu M,Qin S,Yu P,Li B,Xu J,Ondrejcak T,Klyubin I,Rowan MJ,Hu NW</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to uncover brain plasticity-related cellular and molecular processes of tau phosphorylation at key sites in health and aging.</div> <div itemprodp="datePublished">Thu Sep 08 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35259518"> <div itemprop="name">Nuclear and cellular, micro and nano calcification in Alzheimer's disease patients and correlation to phosphorylated Tau.</div> </a> <div itemprop="about">Acta biomaterialia</div> <div itemprop="author">Tsolaki E,Csincsik L,Xue J,Lengyel I,Bertazzo S</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to show here that AD patients' brains present microcalcification associated with the neuronal cell nuclei and cell projections, and that these are related to the presence of pTau.</div> <div itemprodp="datePublished">Fri Apr 15 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35944999"> <div itemprop="name">Downregulating PTBP1 Fails to Convert Astrocytes into Hippocampal Neurons and to Alleviate Symptoms in Alzheimer's Mouse Models.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Guo T,Pan X,Jiang G,Zhang D,Qi J,Shao L,Wang Z,Xu H,Zhao Y</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to suggest that cell fate conversion strategy for neurodegenerative disease therapy through manipulating one single gene, such as PTBP1, warrants more rigorous scrutiny.</div> <div itemprodp="datePublished">Wed Sep 21 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36154878"> <div itemprop="name">Alzheimer PHF-tau aggregates do not spread tau pathology to the brain via the Retino-tectal projection after intraocular injection in male mouse models.</div> </a> <div itemprop="about">Neurobiology of disease</div> <div itemprop="author">de Fisenne MA,Yilmaz Z,De Decker R,Suain V,Buée L,Ando K,Brion JP,Leroy K</div> <div itemprop="description">MN1020 was used in Western Blotting to suggest that retinal ganglion cells exhibit a resistance to develop a tau pathology, and that eye surgery is not a major iatrogenic risk of transmission of tau pathology, contrary to what has been observed for transmission of infectious prions in prion diseases.</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34992270"> <div itemprop="name">Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow.</div> </a> <div itemprop="about">Nature biomedical engineering</div> <div itemprop="author">Xie C,Zhuang XX,Niu Z,Ai R,Lautrup S,Zheng S,Jiang Y,Han R,Gupta TS,Cao S,Lagartos-Donate MJ,Cai CZ,Xie LM,Caponio D,Wang WW,Schmauck-Medina T,Zhang J,Wang HL,Lou G,Xiao X,Zheng W,Palikaras K,Yang G,Caldwell KA,Caldwell GA,Shen HM,Nilsen H,Lu JH,Fang EF</div> <div itemprop="description">MN1020 was used in Immunohistochemistry, Western Blot to report the combined use of unsupervised machine learning and a cross-species approach for the screening and experimental validation of new mitophagy-inducing compounds.</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34992270"> <div itemprop="name">Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow.</div> </a> <div itemprop="about">Nature biomedical engineering</div> <div itemprop="author">Xie C,Zhuang XX,Niu Z,Ai R,Lautrup S,Zheng S,Jiang Y,Han R,Gupta TS,Cao S,Lagartos-Donate MJ,Cai CZ,Xie LM,Caponio D,Wang WW,Schmauck-Medina T,Zhang J,Wang HL,Lou G,Xiao X,Zheng W,Palikaras K,Yang G,Caldwell KA,Caldwell GA,Shen HM,Nilsen H,Lu JH,Fang EF</div> <div itemprop="description">MN1020 was used in Immunohistochemistry, Western Blot to report the combined use of unsupervised machine learning and a cross-species approach for the screening and experimental validation of new mitophagy-inducing compounds.</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34992270"> <div itemprop="name">Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow.</div> </a> <div itemprop="about">Nature biomedical engineering</div> <div itemprop="author">Xie C,Zhuang XX,Niu Z,Ai R,Lautrup S,Zheng S,Jiang Y,Han R,Gupta TS,Cao S,Lagartos-Donate MJ,Cai CZ,Xie LM,Caponio D,Wang WW,Schmauck-Medina T,Zhang J,Wang HL,Lou G,Xiao X,Zheng W,Palikaras K,Yang G,Caldwell KA,Caldwell GA,Shen HM,Nilsen H,Lu JH,Fang EF</div> <div itemprop="description">MN1020 was used in Immunohistochemistry, Western Blot to report the combined use of unsupervised machine learning and a cross-species approach for the screening and experimental validation of new mitophagy-inducing compounds.</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34992270"> <div itemprop="name">Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow.</div> </a> <div itemprop="about">Nature biomedical engineering</div> <div itemprop="author">Xie C,Zhuang XX,Niu Z,Ai R,Lautrup S,Zheng S,Jiang Y,Han R,Gupta TS,Cao S,Lagartos-Donate MJ,Cai CZ,Xie LM,Caponio D,Wang WW,Schmauck-Medina T,Zhang J,Wang HL,Lou G,Xiao X,Zheng W,Palikaras K,Yang G,Caldwell KA,Caldwell GA,Shen HM,Nilsen H,Lu JH,Fang EF</div> <div itemprop="description">MN1020 was used in Immunohistochemistry, Western Blot to report the combined use of unsupervised machine learning and a cross-species approach for the screening and experimental validation of new mitophagy-inducing compounds.</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35477957"> <div itemprop="name">High altitude is associated with pTau deposition, neuroinflammation, and myelin loss.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Iacono D,Murphy EK,Sherman PM,Chapapas H,Cerqueira B,Christensen C,Perl DP,Sladky J</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to illustrate, for the first time, changes occurring in large mammalian brains after exposure to nonhypoxic-hypobaria and open new pathophysiological views on the interaction among hypobaria, pTau accumulation, neuroinflammation, and myelination in large mammals exposed to HA.</div> <div itemprodp="datePublished">Wed Apr 27 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35941185"> <div itemprop="name">Synaptosome microRNAs regulate synapse functions in Alzheimer's disease.</div> </a> <div itemprop="about">NPJ genomic medicine</div> <div itemprop="author">Kumar S,Orlov E,Gowda P,Bose C,Swerdlow RH,Lahiri DK,Reddy PH</div> <div itemprop="description">MN1020 was used in Western Blotting to describe synaptic versus cytosolic miRNAs in Alzheimer's disease and their significance in synapse function.</div> <div itemprodp="datePublished">Mon Aug 08 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35950093"> <div itemprop="name">Prevalence of chronic traumatic encephalopathy in the Sydney Brain Bank.</div> </a> <div itemprop="about">Brain communications</div> <div itemprop="author">McCann H,Bahar AY,Burkhardt K,Gardner AJ,Halliday GM,Iverson GL,Shepherd CE</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to suggest that isolated traumatic brain injury in the general population is unlikely to cause chronic traumatic encephalopathy neuropathologic change but may be associated with increased brain ageing.</div> <div itemprodp="datePublished">Sat Aug 13 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35170061"> <div itemprop="name">Tau nuclear translocation is a leading step in tau pathology process through P53 stabilization and nucleolar dispersion.</div> </a> <div itemprop="about">Journal of neuroscience research</div> <div itemprop="author">Roqanian S,Ahmadian S,Nabavi SM,Pakdaman H,Shafiezadeh M,Goudarzi G,Shahpasand K</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to indicate that P-tau nuclear translocation results in p53-dependent apoptosis and nucleolar dispersion, which is consistent with neurodegeneration.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36217211"> <div itemprop="name">Altered basal forebrain function during whole-brain network activity at pre- and early-plaque stages of Alzheimer's disease in TgF344-AD rats.</div> </a> <div itemprop="about">Alzheimer's research & therapy</div> <div itemprop="author">van den Berg M,Adhikari MH,Verschuuren M,Pintelon I,Vasilkovska T,Van Audekerke J,Missault S,Heymans L,Ponsaerts P,De Vos WH,Van der Linden A,Keliris GA,Verhoye M</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to investigate how whole-brain networks are influenced at pre- and early-plague stages of AD and if these manifestations are associated with concomitant cellular and synaptic deficits.</div> <div itemprodp="datePublished">Mon Oct 10 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35446108"> <div itemprop="name">Long-term mitochondrial stress induces early steps of Tau aggregation by increasing reactive oxygen species levels and affecting cellular proteostasis.</div> </a> <div itemprop="about">Molecular biology of the cell</div> <div itemprop="author">Samluk L,Ostapczuk P,Dziembowska M</div> <div itemprop="description">MN1020 was used in Western Blotting to indicate that long-term mitochondrial stress may induce early steps of Tau protein aggregation by affecting oxidative balance and cellular proteostasis.</div> <div itemprodp="datePublished">Fri Jul 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35194165"> <div itemprop="name">APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer's pathology in trisomy 21 neurons.</div> </a> <div itemprop="about">Molecular psychiatry</div> <div itemprop="author">Wu CI,Vinton EA,Pearse RV,Heo K,Aylward AJ,Hsieh YC,Bi Y,Adeleye S,Fancher S,Duong DM,Seyfried NT,Schwarz TL,Young-Pearse TL</div> <div itemprop="description">MN1020 was used in Western Blotting to provide insights into the initial molecular alterations within neurons that ultimately lead to synaptic loss and axonal degeneration in Down syndrome and early-onset AD. © 2022.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34873815"> <div itemprop="name">Differential expression of tau species and the association with cognitive decline and synaptic loss in Alzheimer's disease.</div> </a> <div itemprop="about">Alzheimer's & dementia : the journal of the Alzheimer's Association</div> <div itemprop="author">Saroja SR,Sharma A,Hof PR,Pereira AC</div> <div itemprop="description">MN1020 was used in Western Blotting to propose that tau species from NFT-predominant tissues possess greater levels of degenerative properties, thereby causing synaptic loss and cognitive decline.</div> <div itemprodp="datePublished">Thu Sep 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35292638"> <div itemprop="name">Tau deposition patterns are associated with functional connectivity in primary tauopathies.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Franzmeier N,Brendel M,Beyer L,Slemann L,Kovacs GG,Arzberger T,Kurz C,Respondek G,Lukic MJ,Biel D,Rubinski A,Frontzkowski L,Hummel S,Müller A,Finze A,Palleis C,Joseph E,Weidinger E,Katzdobler S,Song M,Biechele G,Kern M,Scheifele M,Rauchmann BS,Perneczky R,Rullman M,Patt M,Schildan A,Barthel H,Sabri O,Rumpf JJ,Schroeter ML,Classen J,Villemagne V,Seibyl J,Stephens AW,Lee EB,Coughlin DG,Giese A,Grossman M,McMillan CT,Gelpi E,Molina-Porcel L,Compta Y,van Swieten JC,Laat LD,Troakes C,Al-Sarraj S,Robinson JL,Xie SX,Irwin DJ,Roeber S,Herms J,Simons M,Bartenstein P,Lee VM,Trojanowski JQ,Levin J,Höglinger G,Ewers M</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to provides combined in vivo tau-PET and histopathological evidence that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.</div> <div itemprodp="datePublished">Tue Mar 15 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35357812"> <div itemprop="name">O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies.</div> </a> <div itemprop="about">ACS chemical neuroscience</div> <div itemprop="author">Permanne B,Sand A,Ousson S,Nény M,Hantson J,Schubert R,Wiessner C,Quattropani A,Beher D</div> <div itemprop="description">MN1020 was used in Inhibition Assays to provide a strong rationale for the development of OGA inhibitors as disease-modifying agents in both tauopathies and α-synucleinopathies.</div> <div itemprodp="datePublished">Wed Apr 20 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35892672"> <div itemprop="name">Proteomic Assessment of C57BL/6 Hippocampi after Non-Selective Pharmacological Inhibition of Nitric Oxide Synthase Activity: Implications of Seizure-like Neuronal Hyperexcitability Followed by Tauopathy.</div> </a> <div itemprop="about">Biomedicines</div> <div itemprop="author">Hendrickx JO,Adams C,Sieben A,Laukens K,Van Dam D,De Meyer GRY</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate the progressive molecular signatures in hippocampal tissue via LC-MS/MS proteomic analysis.</div> <div itemprodp="datePublished">Fri Jul 22 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35813949"> <div itemprop="name">The Periodontal Pathogen <i>Fusobacterium nucleatum</i> Exacerbates Alzheimer's Pathogenesis <i>via</i> Specific Pathways.</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Wu H,Qiu W,Zhu X,Li X,Xie Z,Carreras I,Dedeoglu A,Van Dyke T,Han YW,Karimbux N,Tu Q,Cheng L,Chen J</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to identify the pathways through which F. nucleatum modulates molecular elements in enhancing AD symptoms and signs.</div> <div itemprodp="datePublished">Fri Jan 20 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35813949"> <div itemprop="name">The Periodontal Pathogen <i>Fusobacterium nucleatum</i> Exacerbates Alzheimer's Pathogenesis <i>via</i> Specific Pathways.</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Wu H,Qiu W,Zhu X,Li X,Xie Z,Carreras I,Dedeoglu A,Van Dyke T,Han YW,Karimbux N,Tu Q,Cheng L,Chen J</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to identify the pathways through which F. nucleatum modulates molecular elements in enhancing AD symptoms and signs.</div> <div itemprodp="datePublished">Fri Jan 20 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36245925"> <div itemprop="name">Decreased anterograde transport coupled with sustained retrograde transport contributes to reduced axonal mitochondrial density in tauopathy neurons.</div> </a> <div itemprop="about">Frontiers in molecular neuroscience</div> <div itemprop="author">Sabui A,Biswas M,Somvanshi PR,Kandagiri P,Gorla M,Mohammed F,Tammineni P</div> <div itemprop="description">MN1020 was used in Western Blotting to indicate that decreased kinesin-mediated transport coupled with sustained retrograde transport might reduce axonal mitochondria in tauopathy neurons, thus contributing to the synaptic deficits in Alzheimer's disease (AD) and other tauopathies.</div> <div itemprodp="datePublished">Wed Oct 19 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36245925"> <div itemprop="name">Decreased anterograde transport coupled with sustained retrograde transport contributes to reduced axonal mitochondrial density in tauopathy neurons.</div> </a> <div itemprop="about">Frontiers in molecular neuroscience</div> <div itemprop="author">Sabui A,Biswas M,Somvanshi PR,Kandagiri P,Gorla M,Mohammed F,Tammineni P</div> <div itemprop="description">MN1020 was used in Western Blotting to indicate that decreased kinesin-mediated transport coupled with sustained retrograde transport might reduce axonal mitochondria in tauopathy neurons, thus contributing to the synaptic deficits in Alzheimer's disease (AD) and other tauopathies.</div> <div itemprodp="datePublished">Wed Oct 19 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35513862"> <div itemprop="name">P38 initiates degeneration of midbrain GABAergic and glutamatergic neurons in diabetes models.</div> </a> <div itemprop="about">The European journal of neuroscience</div> <div itemprop="author">Farhadi A,Totonchi M,Nabavi SM,Baharvand H,Pakdaman H,Hajizadeh-Saffar E,Mousavi SA,Hadi F,Al-Sinawi H,Li Q,Zhang JS,Tahamtani Y,Shahpasand K</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to elucidate accumulation of cis P-tau in midbrain and corpus callosum, and establish P38 as a central mediator of diabetes mellitus-induced tau pathology.</div> <div itemprodp="datePublished">Fri Jul 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35236988"> <div itemprop="name">FSH blockade improves cognition in mice with Alzheimer's disease.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Xiong J,Kang SS,Wang Z,Liu X,Kuo TC,Korkmaz F,Padilla A,Miyashita S,Chan P,Zhang Z,Katsel P,Burgess J,Gumerova A,Ievleva K,Sant D,Yu SP,Muradova V,Frolinger T,Lizneva D,Iqbal J,Goosens KA,Gera S,Rosen CJ,Haroutunian V,Ryu V,Yuen T,Zaidi M,Ye K</div> <div itemprop="description">MN1020 was used in Western Blotting and Immunohistochemistry to suggest a causal role for rising serum FSH levels in the exaggerated Alzheimer's disease pathophysiology during menopause, but also reveal an opportunity for treating Alzheimer's disease, obesity, osteoporosis and dyslipidaemia with a single FSH-blocking agent.</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35236988"> <div itemprop="name">FSH blockade improves cognition in mice with Alzheimer's disease.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Xiong J,Kang SS,Wang Z,Liu X,Kuo TC,Korkmaz F,Padilla A,Miyashita S,Chan P,Zhang Z,Katsel P,Burgess J,Gumerova A,Ievleva K,Sant D,Yu SP,Muradova V,Frolinger T,Lizneva D,Iqbal J,Goosens KA,Gera S,Rosen CJ,Haroutunian V,Ryu V,Yuen T,Zaidi M,Ye K</div> <div itemprop="description">MN1020 was used in Western Blotting and Immunohistochemistry to suggest a causal role for rising serum FSH levels in the exaggerated Alzheimer's disease pathophysiology during menopause, but also reveal an opportunity for treating Alzheimer's disease, obesity, osteoporosis and dyslipidaemia with a single FSH-blocking agent.</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36474289"> <div itemprop="name">Axonal degeneration in the anterior insular cortex is associated with Alzheimer's co-pathology in Parkinson's disease and dementia with Lewy bodies.</div> </a> <div itemprop="about">Translational neurodegeneration</div> <div itemprop="author">Fathy YY,Jonkman LE,Bol JJ,Timmermans E,Jonker AJ,Rozemuller AJM,van de Berg WDJ</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to highlight the selective vulnerability of the anterior insular sub-regions to various converging pathologies, leading to impaired axonal integrity in PD, PDD and DLB, disrupting their functional properties and potentially contributing to cognitive, emotional, and autonomic deficits.</div> <div itemprodp="datePublished">Wed Dec 07 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35810473"> <div itemprop="name">Effects of toxic apolipoprotein E fragments on Tau phosphorylation and cognitive impairment in neonatal mice under sevoflurane anesthesia.</div> </a> <div itemprop="about">Brain and behavior</div> <div itemprop="author">Yu Y,Yang M,Zhuang X,Pan J,Zhao Y,Yu Y</div> <div itemprop="description">MN1020 was used in Western Blotting and Immunohistochemistry to suggest that elevated ApoE fragments rather than full-length ApoE might be one of the underlying mechanisms of age-dependent Tau phosphorylation and cognitive impairment in young mice following sevoflurane anesthesia.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35810473"> <div itemprop="name">Effects of toxic apolipoprotein E fragments on Tau phosphorylation and cognitive impairment in neonatal mice under sevoflurane anesthesia.</div> </a> <div itemprop="about">Brain and behavior</div> <div itemprop="author">Yu Y,Yang M,Zhuang X,Pan J,Zhao Y,Yu Y</div> <div itemprop="description">MN1020 was used in Western Blotting and Immunohistochemistry to suggest that elevated ApoE fragments rather than full-length ApoE might be one of the underlying mechanisms of age-dependent Tau phosphorylation and cognitive impairment in young mice following sevoflurane anesthesia.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35563179"> <div itemprop="name">Differences in Tau Seeding in Newborn and Adult Wild-Type Mice.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Ferrer I,Andrés-Benito P,Garcia-Esparcia P,López-Gonzalez I,Valiente D,Jordán-Pirla M,Carmona M,Sala-Jarque J,Gil V,Del Rio JA</div> <div itemprop="description">MN1020 was used in Western Blotting and Immunohistochemistry to show that (a) differences in tau seeding between newborn and young adults may be related to the ratios between 3Rtau and 4Rtau, and the shift to 4Rtau predominance in adults, together with the immaturity of connections in newborn mice, and (b) intracerebral inoculation of sAD PHFs in newborn mice does not protect from tau seeding following intracerebral inoculation of sAD PHFs in young/adult mice.</div> <div itemprodp="datePublished">Tue Apr 26 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35563179"> <div itemprop="name">Differences in Tau Seeding in Newborn and Adult Wild-Type Mice.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Ferrer I,Andrés-Benito P,Garcia-Esparcia P,López-Gonzalez I,Valiente D,Jordán-Pirla M,Carmona M,Sala-Jarque J,Gil V,Del Rio JA</div> <div itemprop="description">MN1020 was used in Western Blotting and Immunohistochemistry to show that (a) differences in tau seeding between newborn and young adults may be related to the ratios between 3Rtau and 4Rtau, and the shift to 4Rtau predominance in adults, together with the immaturity of connections in newborn mice, and (b) intracerebral inoculation of sAD PHFs in newborn mice does not protect from tau seeding following intracerebral inoculation of sAD PHFs in young/adult mice.</div> <div itemprodp="datePublished">Tue Apr 26 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35955510"> <div itemprop="name">Norovirus Intestinal Infection and Lewy Body Disease in an Older Patient with Acute Cognitive Impairment.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Moreno-Valladares M,Moncho-Amor V,Bernal-Simon I,Agirre-Iturrioz E,Álvarez-Satta M,Matheu A</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to report a concomitant norovirus infection with synthesis of alpha-synuclein in the gastrointestinal mucosa and Lewy pathology in the CNS, which might support Braak's hypothesis about the pathogenic mechanisms underlying synucleinopathies.</div> <div itemprodp="datePublished">Fri Jul 29 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35808999"> <div itemprop="name">Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Di Liberto G,Egervari K,Kreutzfeldt M,Schürch CM,Hewer E,Wagner I,Du Pasquier R,Merkler D</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to elucidate some of the molecular signatures adopted by CNS phagocytes in HIV-positive patients and contribute to the understanding of how HIV might pave the way to other forms of cognitive decline in ageing HIV patient populations.</div> <div itemprodp="datePublished">Sat Aug 27 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35241183"> <div itemprop="name">Tuberous sclerosis complex is a novel, amyloid-independent tauopathy associated with elevated phosphorylated 3R/4R tau aggregation.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Liu AJ,Lusk JB,Ervin J,Burke J,O'Brien R,Wang SJ</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to show that Tuberous Sclerosis Complex Associated Neuropsychiatric Disorder symptoms are due to the accumulation of the phosphorylated tau isoform seen in Alzheimer's disease.</div> <div itemprodp="datePublished">Thu Mar 03 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36257314"> <div itemprop="name">SYK coordinates neuroprotective microglial responses in neurodegenerative disease.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Ennerfelt H,Frost EL,Shapiro DA,Holliday C,Zengeler KE,Voithofer G,Bolte AC,Lammert CR,Kulas JA,Ulland TK,Lukens JR</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to study the critical intracellular molecules that orchestrate neuroprotective functions of microglia.</div> <div itemprodp="datePublished">Thu Oct 27 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36443837"> <div itemprop="name">Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models.</div> </a> <div itemprop="about">Alzheimer's research & therapy</div> <div itemprop="author">Lee HY,Yoon S,Lee JH,Park K,Jung Y,Cho I,Lee D,Shin J,Kim K,Kim S,Kim J,Kim K,Han SH,Kim SM,Kim HJ,Kim HY,Kim I,Kim YS</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that YIAD002 interferes with intermolecular β-sheet fibrillation by directly interacting with KLVFFA and IGLMVG domains of Aβ.</div> <div itemprodp="datePublished">Tue Nov 29 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35093145"> <div itemprop="name">Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer's disease.</div> </a> <div itemprop="about">Molecular neurodegeneration</div> <div itemprop="author">Zhang G,Meng L,Wang Z,Peng Q,Chen G,Xiong J,Zhang Z</div> <div itemprop="description">MN1020 was used in Immunohistochemistry (Paraffin) to examine the presence of islet amyloid polypeptide IAPP in the neurofibrillary tangles of Alzheimer's disease patients. Then test the effect of IAPP on tau aggregation.</div> <div itemprodp="datePublished">Sat Jan 29 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35093145"> <div itemprop="name">Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer's disease.</div> </a> <div itemprop="about">Molecular neurodegeneration</div> <div itemprop="author">Zhang G,Meng L,Wang Z,Peng Q,Chen G,Xiong J,Zhang Z</div> <div itemprop="description">MN1020 was used in Immunohistochemistry (Paraffin) to examine the presence of islet amyloid polypeptide IAPP in the neurofibrillary tangles of Alzheimer's disease patients. Then test the effect of IAPP on tau aggregation.</div> <div itemprodp="datePublished">Sat Jan 29 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35093145"> <div itemprop="name">Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer's disease.</div> </a> <div itemprop="about">Molecular neurodegeneration</div> <div itemprop="author">Zhang G,Meng L,Wang Z,Peng Q,Chen G,Xiong J,Zhang Z</div> <div itemprop="description">MN1020 was used in Immunohistochemistry (Paraffin) to examine the presence of islet amyloid polypeptide IAPP in the neurofibrillary tangles of Alzheimer's disease patients. Then test the effect of IAPP on tau aggregation.</div> <div itemprodp="datePublished">Sat Jan 29 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36170815"> <div itemprop="name">Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Rangan P,Lobo F,Parrella E,Rochette N,Morselli M,Stephen TL,Cremonini AL,Tagliafico L,Persia A,Caffa I,Monacelli F,Odetti P,Bonfiglio T,Nencioni A,Pigliautile M,Boccardi V,Mecocci P,Pike CJ,Cohen P,LaDu MJ,Pellegrini M,Xia K,Tran K,Ann B,Chowdhury D,Longo VD</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to we show that fasting-mimicking diet cycles reduce cognitive decline and Alzheimer's disease (AD) pathology in E4FAD and 3xTg AD mouse models, with effects superior to those caused by protein restriction cycles.</div> <div itemprodp="datePublished">Tue Sep 27 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36544231"> <div itemprop="name">Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Chen S,Chang Y,Li L,Acosta D,Li Y,Guo Q,Wang C,Turkes E,Morrison C,Julian D,Hester ME,Scharre DW,Santiskulvong C,Song SX,Plummer JT,Serrano GE,Beach TG,Duff KE,Ma Q,Fu H</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to utilize the 10 Visium platform to define the spatial transcriptomic profile in both AD and control (CT) MTG.</div> <div itemprodp="datePublished">Wed Dec 21 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33891876"> <div itemprop="name">Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Bourdenx M,Martín-Segura A,Scrivo A,Rodriguez-Navarro JA,Kaushik S,Tasset I,Diaz A,Storm NJ,Xin Q,Juste YR,Stevenson E,Luengo E,Clement CC,Choi SJ,Krogan NJ,Mosharov EV,Santambrogio L,Grueninger F,Collin L,Swaney DL,Sulzer D,Gavathiotis E,Cuervo AM</div> <div itemprop="description">MN1020 was used in Enzyme-linked immunosorbent assay to conclude that functional CMA is essential for neuronal proteostasis through the maintenance of a subset of the proteome with a higher risk of misfolding than the general proteome.</div> <div itemprodp="datePublished">Thu May 13 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33586680"> <div itemprop="name">Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Sandusky-Beltran LA,Kovalenko A,Placides DS,Ratnasamy K,Ma C,Hunt JB,Liang H,Calahatian JIT,Michalski C,Fahnestock M,Blair LJ,Darling AL,Baker JD,Fontaine SN,Dickey CA,Gamsby JJ,Nash KR,Abner E,Selenica MB,Lee DC</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to report a unique interaction between polyamine metabolism, behavioral impairment, and tau fate.</div> <div itemprodp="datePublished">Mon Feb 15 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33848474"> <div itemprop="name">Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components.</div> </a> <div itemprop="about">Neuron</div> <div itemprop="author">Lester E,Ooi FK,Bakkar N,Ayers J,Woerman AL,Wheeler J,Bowser R,Carlson GA,Prusiner SB,Parker R</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to identify tau alteration of nuclear speckles as a feature of tau aggregation that may contribute to the pathology of tau aggregates.</div> <div itemprodp="datePublished">Wed May 19 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33246331"> <div itemprop="name">Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Ruan Z,Pathak D,Venkatesan Kalavai S,Yoshii-Kitahara A,Muraoka S,Bhatt N,Takamatsu-Yukawa K,Hu J,Wang Y,Hersh S,Ericsson M,Gorantla S,Gendelman HE,Kayed R,Ikezu S,Luebke JI,Ikezu T</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to propose a novel mechanism for the spread of tau in hippocampal GABAergic interneurons via brain-derived extracellular vesicles and their subsequent neuronal dysfunction.</div> <div itemprodp="datePublished">Fri Feb 12 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32632204"> <div itemprop="name">Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids.</div> </a> <div itemprop="about">Molecular psychiatry</div> <div itemprop="author">Pérez MJ,Ivanyuk D,Panagiotakopoulou V,Di Napoli G,Kalb S,Brunetti D,Al-Shaana R,Kaeser SA,Fraschka SA,Jucker M,Zeviani M,Viscomi C,Deleidi M</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to support a mechanistic link between mitochondrial function and common neurodegenerative proteinopathies.</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33459145"> <div itemprop="name">Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.</div> </a> <div itemprop="about">Autophagy</div> <div itemprop="author">Chambraud B,Daguinot C,Guillemeau K,Genet M,Dounane O,Meduri G,Poüs C,Baulieu EE,Giustiniani J</div> <div itemprop="description">MN1020 was used in Immunocytochemistry-immunoflourescence to demonstrate that FKBP4 decrease in a human neuronal cell line (SH-SY5Y) and in dorsal root ganglion (DRG) neurons from human MAPTP301S transgenic mice affected the function of the autophagy-lysosomal system under MAPT induced proteotoxic stress conditions.</div> <div itemprodp="datePublished">Mon Nov 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34187889"> <div itemprop="name">Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Xu Y,Propson NE,Du S,Xiong W,Zheng H</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to report that Atg7 plays an essential role in the regulation of microglial lipid metabolism and neuroinflammation.</div> <div itemprodp="datePublished">Tue Jul 06 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34187889"> <div itemprop="name">Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Xu Y,Propson NE,Du S,Xiong W,Zheng H</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to report that Atg7 plays an essential role in the regulation of microglial lipid metabolism and neuroinflammation.</div> <div itemprodp="datePublished">Tue Jul 06 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32908202"> <div itemprop="name">RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation.</div> </a> <div itemprop="about">Cell death and differentiation</div> <div itemprop="author">Zhao D,Zhou Y,Huo Y,Meng J,Xiao X,Han L,Zhang X,Luo H,Can D,Sun H,Huang TY,Wang X,Zhang J,Liu FR,Xu H,Zhang YW</div> <div itemprop="description">MN1020 was used in Western Blot to observe retarded axon outgrowth, elevated p35 and p25 protein levels, and increased tau phosphorylation at major Cdk5 phosphorylation sites in Rps23rg1 knockout (KO) mice.</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34080759"> <div itemprop="name">Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's disease.</div> </a> <div itemprop="about">Aging cell</div> <div itemprop="author">Zhang J,Wu N,Wang S,Yao Z,Xiao F,Lu J,Chen B</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to contribute to our understanding of the relationship between neuronal loss and Aβ deposits in the absence of pathologic tau.</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33716161"> <div itemprop="name">ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease.</div> </a> <div itemprop="about">Progress in neurobiology</div> <div itemprop="author">Wang ZH,Xia Y,Liu P,Liu X,Edgington-Mitchell L,Lei K,Yu SP,Wang XC,Ye K</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate how ApoE4 contributes to Alzheimer's Disease pathogenesis.</div> <div itemprodp="datePublished">Thu Jul 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33319235"> <div itemprop="name">Distinguishing Amnestic Mild Cognitive Impairment From HIV-Associated Neurocognitive Disorders.</div> </a> <div itemprop="about">The Journal of infectious diseases</div> <div itemprop="author">Sundermann EE,Bondi MW,Campbell LM,Gouaux B,Moore RC,Soontornniyomkij V,Moore DJ</div> <div itemprop="description">MN1020 was used in Immunohistochemistry (Paraffin) to conclude that amnestic mild cognitive impairment criteria that include recognition impairment may help to detect AD-like cognitive/biomarker profiles among PWH.</div> <div itemprodp="datePublished">Mon Aug 02 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33089580"> <div itemprop="name">Contribution of the astrocytic tau pathology to synapse loss in progressive supranuclear palsy and corticobasal degeneration.</div> </a> <div itemprop="about">Brain pathology (Zurich, Switzerland)</div> <div itemprop="author">Briel N,Pratsch K,Roeber S,Arzberger T,Herms J</div> <div itemprop="description">MN1020 was used in Immunocytochemistry to highlight astrocytic pTau as an important subject of prospective research and as a potential cellular target for therapeutic approaches in the primary tauopathies PSP and CBD.</div> <div itemprodp="datePublished">Thu Jul 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32716602"> <div itemprop="name">PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation.</div> </a> <div itemprop="about">Brain pathology (Zurich, Switzerland)</div> <div itemprop="author">Reimer L,Betzer C,Kofoed RH,Volbracht C,Fog K,Kurhade C,Nilsson E,Överby AK,Jensen PH</div> <div itemprop="description">MN1020 was used in Western Blot to indicate that PKR, independent of other kinases and upon acute brain inflammation, is capable of triggering pathological modulation of tau, which, in turn, might form the initial pathologic seed in several tauopathies such as Alzheimer's disease and Chronic traumatic encephalopathy where inflammation is severe.</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32810333"> <div itemprop="name">Distribution of tau hyperphosphorylation in canine dementia resembles early Alzheimer's disease and other tauopathies.</div> </a> <div itemprop="about">Brain pathology (Zurich, Switzerland)</div> <div itemprop="author">Abey A,Davies D,Goldsbury C,Buckland M,Valenzuela M,Duncan T</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate phosphorylated tau (p-tau) in six Canine Cognitive Dysfunction brains and six controls using the AT8 antibody (later stage neurofibrillary pathology), and an antibody against Serine 396 p-tau (earlier stage tau dysfunction).</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33336479"> <div itemprop="name">Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer's and small vessel disease pathologies.</div> </a> <div itemprop="about">Brain pathology (Zurich, Switzerland)</div> <div itemprop="author">Waller R,Narramore R,Simpson JE,Heath PR,Verma N,Tinsley M,Barnes JR,Haris HT,Henderson FE,Matthews FE,Richardson CD,Brayne C,Ince PG,Kalaria RN,Wharton SB</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to conclude that understanding the heterogeneity in white matter neuroinflammation will be important for the therapeutic targeting of age-associated white matter damage.</div> <div itemprodp="datePublished">Sat May 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33980545"> <div itemprop="name">Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer's Disease Model Mice.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Takamura R,Mizuta K,Sekine Y,Islam T,Saito T,Sato M,Ohkura M,Nakai J,Ohshima T,Saido TC,Hayashi Y</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate how spatial and temporal information encoded and represented in the hippocampal neuron are impaired under amyloid β pathology.</div> <div itemprodp="datePublished">Wed Jun 16 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33368549"> <div itemprop="name">MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis.</div> </a> <div itemprop="about">Neuropathology and applied neurobiology</div> <div itemprop="author">Bettencourt C,Miki Y,Piras IS,de Silva R,Foti SC,Talboom JS,Revesz T,Lashley T,Balazs R,Viré E,Warner TT,Huentelman MJ,Holton JL</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to support a role for DNA methylation in downregulation of MOBP mRNA in MSA. Most importantly, the identification of MOBP and HIP1 as new constituents of GCIs emphasizes the relevance of these two loci to the pathogenesis of MSA.</div> <div itemprodp="datePublished">Sun Aug 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33969516"> <div itemprop="name">Faster disease progression in Parkinson's disease with type 2 diabetes is not associated with increased α-synuclein, tau, amyloid-β or vascular pathology.</div> </a> <div itemprop="about">Neuropathology and applied neurobiology</div> <div itemprop="author">de Pablo-Fernández E,Courtney R,Rockliffe A,Gentleman S,Holton JL,Warner TT</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to conclude that pre-existing type 2 diabetes contributes to faster disease progression and reduced survival in Parkinson's disease which is not driven by increased vascular, Lewy or Alzheimer's pathologies.</div> <div itemprodp="datePublished">Wed Dec 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33258073"> <div itemprop="name">The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome.</div> </a> <div itemprop="about">Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics</div> <div itemprop="author">Zuliani I,Lanzillotta C,Tramutola A,Francioso A,Pagnotta S,Barone E,Perluigi M,Di Domenico F</div> <div itemprop="description">MN1020 was used in Western Blotting to determine the role of protein O-GlcNacylation in the down syndrome brain.</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33776745"> <div itemprop="name">Cerebellar Calcium-Binding Protein and Neurotrophin Receptor Defects in Down Syndrome and Alzheimer's Disease.</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Miguel JC,Perez SE,Malek-Ahmadi M,Mufson EJ</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to suggest that disturbances in calcium binding proteins play a critical role in cerebellar neuronal dysfunction in adults with DS.</div> <div itemprodp="datePublished">Tue May 11 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33994992"> <div itemprop="name">Increased MANF Expression in the Inferior Temporal Gyrus in Patients With Alzheimer Disease.</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Liu XC,Qi XH,Fang H,Zhou KQ,Wang QS,Chen GH</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to show Alzheimer patients show increased MANF Expression.</div> <div itemprodp="datePublished">Tue May 18 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34992526"> <div itemprop="name">Does Chronic Sleep Fragmentation Lead to Alzheimer's Disease in Young Wild-Type Mice?</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Ba L,Huang L,He Z,Deng S,Xie Y,Zhang M,Jacob C,Antonecchia E,Liu Y,Xiao W,Xie Q,Huang Z,Yi C,D'Ascenzo N,Ding F</div> <div itemprop="description">MN1020 was used in Immunohistochemistry, Western Blot to show whether SF could eventually lead to chronic neurodegeneration if the stress condition is prolonged in time.</div> <div itemprodp="datePublished">Sat Jan 08 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34992526"> <div itemprop="name">Does Chronic Sleep Fragmentation Lead to Alzheimer's Disease in Young Wild-Type Mice?</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Ba L,Huang L,He Z,Deng S,Xie Y,Zhang M,Jacob C,Antonecchia E,Liu Y,Xiao W,Xie Q,Huang Z,Yi C,D'Ascenzo N,Ding F</div> <div itemprop="description">MN1020 was used in Immunohistochemistry, Western Blot to show whether SF could eventually lead to chronic neurodegeneration if the stress condition is prolonged in time.</div> <div itemprodp="datePublished">Sat Jan 08 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33994996"> <div itemprop="name">Hepcidin Increases Cytokines in Alzheimer's Disease and Down's Syndrome Dementia: Implication of Impaired Iron Homeostasis in Neuroinflammation.</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Raha AA,Ghaffari SD,Henderson J,Chakraborty S,Allinson K,Friedland RP,Holland A,Zaman SH,Mukaetova-Ladinska EB,Raha-Chowdhury R</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study levels of ferritin, hepcidin, and IL-16 in patients with Alzheimer's disease and Down's syndrome.</div> <div itemprodp="datePublished">Tue May 18 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33285637"> <div itemprop="name">Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Stojakovic A,Chang SY,Nesbitt J,Pichurin NP,Ostroot MA,Aikawa T,Kanekiyo T,Trushina E</div> <div itemprop="description">MN1020 was used in Western Blotting to investigate the effect of specific MCI inhibitor tricyclic pyrone compound CP2 on levels of human pTau, memory function, long term potentiation (LTP), and energy homeostasis in 18-month-old 3xTg-AD mice and explore the potential mechanisms.</div> <div itemprodp="datePublished">Mon Sep 27 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33252082"> <div itemprop="name">Multi-Target Effects of the Cannabinoid CP55940 on Familial Alzheimer's Disease PSEN1 E280A Cholinergic-Like Neurons: Role of CB1 Receptor.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Soto-Mercado V,Mendivil-Perez M,Jimenez-Del-Rio M,Velez-Pardo C</div> <div itemprop="description">MN1020 was used in Immunocytochemistry-immunoflourescence to evaluate the effect of the synthetic cannabinoid CP55940 (CP) on PSEN1 E280A cholinergic-like nerve cells (PSEN1 ChLNs)-a natural model of familial Alzheimer's disease.</div> <div itemprodp="datePublished">Thu Sep 23 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33511469"> <div itemprop="name">Phosphorylated Tau protein in the myenteric plexus of the ileum and colon of normothermic rats and during synthetic torpor.</div> </a> <div itemprop="about">Cell and tissue research</div> <div itemprop="author">Chiocchetti R,Hitrec T,Giancola F,Sadeghinezhad J,Squarcio F,Galiazzo G,Piscitiello E,De Silva M,Cerri M,Amici R,Luppi M</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to strengthen the hypothesis of a common cellular mechanism triggered by ST, natural hibernation and tauopathies occurring in ENS neurons.</div> <div itemprodp="datePublished">Sat May 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33346120"> <div itemprop="name">Dendritic Spine Remodeling and Synaptic Tau Levels in PS19 Tauopathy Mice.</div> </a> <div itemprop="about">Neuroscience</div> <div itemprop="author">Walker CK,Greathouse KM,Boros BD,Poovey EH,Clearman KR,Ramdas R,Muhammad HM,Herskowitz JH</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study whether hyperphosphorylated tau is associated with detrimental changes in the hippocampus or prefrontal cortex and if these events correspond to tau accumulation in synaptic compartments.</div> <div itemprodp="datePublished">Wed Feb 10 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34169147"> <div itemprop="name">Novel <i>TUBA4A</i> Variant Associated With Familial Frontotemporal Dementia.</div> </a> <div itemprop="about">Neurology. Genetics</div> <div itemprop="author">Mol MO,Wong TH,Melhem S,Basu S,Viscusi R,Galjart N,Rozemuller AJM,Fallini C,Landers JE,Kaat LD,Seelaar H,van Rooij JGJ,van Swieten JC</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate the underlying genetic cause of autosomal dominant frontotemporal dementia.</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33367843"> <div itemprop="name">Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Walker JM,Richardson TE,Farrell K,Iida MA,Foong C,Shang P,Attems J,Ayalon G,Beach TG,Bigio EH,Budson A,Cairns NJ,Corrada M,Cortes E,Dickson DW,Fischer P,Flanagan ME,Franklin E,Gearing M,Glass J,Hansen LA,Haroutunian V,Hof PR,Honig L,Kawas C,Keene CD,Kofler J,Kovacs GG,Lee EB,Lutz MI,Mao Q,Masliah E,McKee AC,McMillan CT,Mesulam MM,Murray M,Nelson PT,Perrin R,Pham T,Poon W,Purohit DP,Rissman RA,Sakai K,Sano M,Schneider JA,Stein TD,Teich AF,Trojanowski JQ,Troncoso JC,Vonsattel JP,Weintraub S,Wolk DA,Woltjer RL,Yamada M,Yu L,White CL,Crary JF</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to highlight the need for a better understanding of the contribution of PART to cognitive impairment and how neurofibrillary degeneration interacts with Aβ pathology in AD and PART.</div> <div itemprodp="datePublished">Wed Jan 20 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33990839"> <div itemprop="name">Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Dickson JR,Yoon H,Frosch MP,Hyman BT</div> <div itemprop="description">MN1020 was used in Immunohistochemistry (Paraffin) to provide evidence that tau induces mislocalization of RPB1 in Alzheimer disease, and since RPB1 is essential for transcription, this raises the possibility that RPB1 mislocalization could lead to fundamental alterations in neuronal health.</div> <div itemprodp="datePublished">Fri Jun 04 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34137273"> <div itemprop="name">Oral Amylin Treatment Reduces the Pathological Cascade of Alzheimer's Disease in a Mouse Model.</div> </a> <div itemprop="about">American journal of Alzheimer's disease and other dementias</div> <div itemprop="author">Na H,Tian H,Zhang Z,Li Q,Yang JB,Mcparland L,Gan Q,Qiu WQ</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to study the potential for an oral-delivered amylin analogue for patients suffering from Alzheimer's disease.</div> <div itemprodp="datePublished">Fri Jun 25 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34137273"> <div itemprop="name">Oral Amylin Treatment Reduces the Pathological Cascade of Alzheimer's Disease in a Mouse Model.</div> </a> <div itemprop="about">American journal of Alzheimer's disease and other dementias</div> <div itemprop="author">Na H,Tian H,Zhang Z,Li Q,Yang JB,Mcparland L,Gan Q,Qiu WQ</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to study the potential for an oral-delivered amylin analogue for patients suffering from Alzheimer's disease.</div> <div itemprodp="datePublished">Fri Jun 25 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33911072"> <div itemprop="name">Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease.</div> </a> <div itemprop="about">Translational psychiatry</div> <div itemprop="author">Lyra E Silva NM,Gonçalves RA,Pascoal TA,Lima-Filho RAS,Resende EPF,Vieira ELM,Teixeira AL,de Souza LC,Peny JA,Fortuna JTS,Furigo IC,Hashiguchi D,Miya-Coreixas VS,Clarke JR,Abisambra JF,Longo BM,Donato J,Fraser PE,Rosa-Neto P,Caramelli P,Ferreira ST,De Felice FG</div> <div itemprop="description">MN1020 was used in Immunocytochemistry to point to IL-6 as a link between cognitive impairment and peripheral metabolic alterations in Alzheimer's disease.</div> <div itemprodp="datePublished">Wed Apr 28 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33750467"> <div itemprop="name">Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer's Disease.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Latina V,Giacovazzo G,Cordella F,Balzamino BO,Micera A,Varano M,Marchetti C,Malerba F,Florio R,Ercole BB,La Regina F,Atlante A,Coccurello R,Di Angelantonio S,Calissano P,Amadoro G</div> <div itemprop="description">MN1020 was used in Western Blotting to find that 12A12mAb administration also exerts a beneficial action on biochemical, morphological and metabolic parameters (i.e. APP/Aβ processing, tau hyperphosphorylation, neuroinflammation, synaptic proteins, microtubule stability, mitochondria-based energy production, neuronal death) associated with ocular injury in the AD phenotype.</div> <div itemprodp="datePublished">Tue Mar 09 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34965424"> <div itemprop="name">The microglial P2Y<sub>6</sub> receptor mediates neuronal loss and memory deficits in neurodegeneration.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Puigdellívol M,Milde S,Vilalta A,Cockram TOJ,Allendorf DH,Lee JY,Dundee JM,Pampuščenko K,Borutaite V,Nuthall HN,Brelstaff JH,Spillantini MG,Brown GC</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that injection of amyloid beta (Aβ) into mouse brain induces microglial phagocytosis of neurons, followed by neuronal and memory loss, and this is all prevented by knockout of P2Y6R.</div> <div itemprodp="datePublished">Tue Dec 28 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33689290"> <div itemprop="name">Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models.</div> </a> <div itemprop="about">ACS chemical neuroscience</div> <div itemprop="author">McMurray L,Macdonald JA,Ramakrishnan NK,Zhao Y,Williamson DW,Tietz O,Zhou X,Kealey S,Fagan SG,Smolek T,Cubinkova V,Žilka N,Spillantini MG,Tolkovsky AM,Goedert M,Aigbirhio FI</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to improve the development of PET imaging probes for visualizing tau pathology in transgenic models of neurodegeneration.</div> <div itemprodp="datePublished">Wed Jun 02 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34260075"> <div itemprop="name">Gut inflammation triggers C/EBPβ/δ-secretase-dependent gut-to-brain propagation of Aβ and Tau fibrils in Alzheimer's disease.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">Chen C,Zhou Y,Wang H,Alam A,Kang SS,Ahn EH,Liu X,Jia J,Ye K</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to indicate that inflammation activates C/EBPβ/δ-secretase and initiates AD-associated pathologies in the gut, which are subsequently transmitted to the brain via the vagus nerve.</div> <div itemprodp="datePublished">Wed Sep 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32602568"> <div itemprop="name">Evaluation of the neuroprotective effect of donepezil in type 2 diabetic rats.</div> </a> <div itemprop="about">Fundamental & clinical pharmacology</div> <div itemprop="author">Gomaa AA,Makboul RM,El-Mokhtar MA,Abdel-Rahman EA,Ahmed EA,Nicola MA</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that donepezil treatment could ameliorate learning and memory impairment in T2D rats through reversal of some of the AD-related alterations, including reduction of amyloid-β burden and ChE activity as well as restoration of glutamate receptor expression.</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33592009"> <div itemprop="name">Corticosteroid-binding-globulin (CBG)-deficient mice show high pY216-GSK3β and phosphorylated-Tau levels in the hippocampus.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Gulfo J,Pérez de San Román J,Ledda A,Junyent F,Ramírez MJ,Gil-Bea FJ,Esteve M,Grasa M</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to indicate that CBG deficiency triggers metabolic imbalance which could lead to damage and long-term neurological pathologies.</div> <div itemprodp="datePublished">Wed Aug 04 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33672582"> <div itemprop="name">Extracellular Protein Aggregates Colocalization and Neuronal Dystrophy in Comorbid Alzheimer's and Creutzfeldt-Jakob Disease: A Micromorphological Pilot Study on 20 Brains.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Jankovska N,Olejar T,Matej R</div> <div itemprop="description">MN1020 was used in Immunohistochemistry (Paraffin) to show that PrPSc aggregation could dominate during co-aggregation with non-compact Aβ in the periphery of Aβ plaques.</div> <div itemprodp="datePublished">Sat Feb 20 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34185417"> <div itemprop="name">Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway.</div> </a> <div itemprop="about">Clinical and translational medicine</div> <div itemprop="author">Wu D,Gao D,Yu H,Pi G,Xiong R,Lei H,Wang X,Liu E,Ye J,Yu H,Gao Y,He T,Jiang T,Sun F,Su J,Song G,Peng W,Yang Y,Wang JZ</div> <div itemprop="description">MN1020 was used in Western Blot to observe an aberrant tau accumulation in the medial septum (MS) of 3xTg and 5xFAD mice, especially in their cholinergic neurons.</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34018922"> <div itemprop="name">Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Zhang X,Zou L,Meng L,Xiong M,Pan L,Chen G,Zheng Y,Xiong J,Wang Z,Duong DM,Zhang Z,Cao X,Wang T,Tang L,Ye K,Zhang Z</div> <div itemprop="description">MN1020 was used in Western Blot to demonstrate that Amphiphysin I mediates tau phosphorylation and synaptic dysfunction in Alzheimer's disease.</div> <div itemprodp="datePublished">Fri May 21 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34209847"> <div itemprop="name">Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia.</div> </a> <div itemprop="about">Journal of clinical medicine</div> <div itemprop="author">Raha-Chowdhury R,Raha AA,Henderson J,Ghaffari SD,Grigorova M,Beresford-Webb J,Allinson K,Chakraborty S,Holland A,Zaman SH</div> <div itemprop="description">MN1020 was used in Immunohistochemistry, Western Blot to determine whether genetic variants and inflammatory proteins are involved in haematopoiesis and cellular processes in Down syndrome compared with age-matched control participants, particularly with respect to neuroinflammation and accelerated ageing.</div> <div itemprodp="datePublished">Tue Jun 29 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34209847"> <div itemprop="name">Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia.</div> </a> <div itemprop="about">Journal of clinical medicine</div> <div itemprop="author">Raha-Chowdhury R,Raha AA,Henderson J,Ghaffari SD,Grigorova M,Beresford-Webb J,Allinson K,Chakraborty S,Holland A,Zaman SH</div> <div itemprop="description">MN1020 was used in Immunohistochemistry, Western Blot to determine whether genetic variants and inflammatory proteins are involved in haematopoiesis and cellular processes in Down syndrome compared with age-matched control participants, particularly with respect to neuroinflammation and accelerated ageing.</div> <div itemprodp="datePublished">Tue Jun 29 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33649380"> <div itemprop="name">Defining early changes in Alzheimer's disease from RNA sequencing of brain regions differentially affected by pathology.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Guennewig B,Lim J,Marshall L,McCorkindale AN,Paasila PJ,Patrick E,Kril JJ,Halliday GM,Cooper AA,Sutherland GT</div> <div itemprop="description">MN1020 was used in Flow Cytometry to conclude that the synaptic deficits that characterise AD may begin with the somatostatin division of inhibitory neurotransmission.</div> <div itemprodp="datePublished">Mon Mar 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35005208"> <div itemprop="name">Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects.</div> </a> <div itemprop="about">Alzheimer's & dementia (New York, N. Y.)</div> <div itemprop="author">Omoluabi T,Torraville SE,Maziar A,Ghosh A,Power KD,Reinhardt C,Harley CW,Yuan Q</div> <div itemprop="description">MN1020 was used in Immunohistochemistry, Western Blot to argue that variations in environmental experiences associated with differing LC activity patterns may account for individual susceptibility to development of AD in humans.</div> <div itemprodp="datePublished">Tue Jan 11 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35005208"> <div itemprop="name">Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects.</div> </a> <div itemprop="about">Alzheimer's & dementia (New York, N. Y.)</div> <div itemprop="author">Omoluabi T,Torraville SE,Maziar A,Ghosh A,Power KD,Reinhardt C,Harley CW,Yuan Q</div> <div itemprop="description">MN1020 was used in Immunohistochemistry, Western Blot to argue that variations in environmental experiences associated with differing LC activity patterns may account for individual susceptibility to development of AD in humans.</div> <div itemprodp="datePublished">Tue Jan 11 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34504195"> <div itemprop="name">Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Herrmann F,Hessmann M,Schaertl S,Berg-Rosseburg K,Brown CJ,Bursow G,Chiki A,Ebneth A,Gehrmann M,Hoeschen N,Hotze M,Jahn S,Johnson PD,Khetarpal V,Kiselyov A,Kottig K,Ladewig S,Lashuel H,Letschert S,Mills MR,Petersen K,Prime ME,Scheich C,Schmiedel G,Wityak J,Liu L,Dominguez C,Muñoz-Sanjuán I,Bard JA</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to present an in-depth pharmacological investigation of the binding characteristics of high-affinity small-molecule binders of HTT oligomerized/amyloid-containing species that could serve as either cellular and in vivo imaging tools or potential therapeutic agents.</div> <div itemprodp="datePublished">Thu Sep 09 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33340360"> <div itemprop="name">A Synergistic Engineering Approach to Build Human Brain Spheroids.</div> </a> <div itemprop="about">Methods in molecular biology (Clifton, N.J.)</div> <div itemprop="author">von Maydell D,Jorfi M</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to generate large-scale arrays of homogeneously sized 3D brain spheroids derived from human-induced pluripotent stem cells (hiPSCs) or immortalized neural progenitor cells to recapitulate Alzheimer's disease (AD) pathology in vitro.</div> <div itemprodp="datePublished">Wed Mar 31 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34524859"> <div itemprop="name">Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice.</div> </a> <div itemprop="about">Science translational medicine</div> <div itemprop="author">Delpech JC,Pathak D,Varghese M,Kalavai SV,Hays EC,Hof PR,Johnson WE,Ikezu S,Medalla M,Luebke JI,Ikezu T</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to demonstrate tau transfer from the ECII to CA1 in mouse brain and provides an early Braak stage preclinical model of AD.</div> <div itemprodp="datePublished">Wed Sep 15 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33492460"> <div itemprop="name">The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer's disease.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Hondius DC,Koopmans F,Leistner C,Pita-Illobre D,Peferoen-Baert RM,Marbus F,Paliukhovich I,Li KW,Rozemuller AJM,Hoozemans JJM,Smit AB</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to provide a comprehensive human based quantitative assessment of protein abundances in GVD and tangle bearing neurons.</div> <div itemprodp="datePublished">Mon Mar 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33939165"> <div itemprop="name">Inhibition of 2-Arachidonoylglycerol Metabolism Alleviates Neuropathology and Improves Cognitive Function in a Tau Mouse Model of Alzheimer's Disease.</div> </a> <div itemprop="about">Molecular neurobiology</div> <div itemprop="author">Hashem J,Hu M,Zhang J,Gao F,Chen C</div> <div itemprop="description">MN1020 was used in Western Blotting to show that JZL184, a potent monoacylglycerol lipase inhibitor, significantly reduced proinflammatory cytokines, astrogliosis, phosphorylated GSK3β and tau, cleaved caspase-3, and phosphorylated NF-kB while it elevated PPARγ in P301S/PS19 mice, a tau mouse model of Alzheimer's disease.</div> <div itemprodp="datePublished">Sun Aug 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33644757"> <div itemprop="name">Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor.</div> </a> <div itemprop="about">Brain communications</div> <div itemprop="author">Maeda J,Minamihisamatsu T,Shimojo M,Zhou X,Ono M,Matsuba Y,Ji B,Ishii H,Ogawa M,Akatsu H,Kaneda D,Hashizume Y,Robinson JL,Lee VM,Saito T,Saido TC,Trojanowski JQ,Zhang MR,Suhara T,Higuchi M,Sahara N</div> <div itemprop="description">MN1020 was used in Immunohistochemistry (Paraffin) to suggest that the down-regulation of microglia P2Y12 receptor, which is characteristic of disease-associated microglia, is intimately associated with tau rather than amyloid-β pathologies from an early stage and could be a sensitive index for neuroinflammatory responses to Alzheimer's disease-related neurodegenerative processes.</div> <div itemprodp="datePublished">Wed Mar 03 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34116706"> <div itemprop="name">Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Sun XY,Li LJ,Dong QX,Zhu J,Huang YR,Hou SJ,Yu XL,Liu RT</div> <div itemprop="description">MN1020 was used in Immunohistochemistry (Paraffin) to show that in combination with the previously reported therapeutic effects of rutin on Aβ pathology, rutin is a promising drug candidate for AD treatment based its combinatorial targeting of tau and Aβ.</div> <div itemprodp="datePublished">Fri Jun 11 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35088035"> <div itemprop="name">Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies.</div> </a> <div itemprop="about">Journal of Alzheimer's disease reports</div> <div itemprop="author">Pitera AP,Hartnell IJ,Scullard L,Williamson KL,Boche D,O'Connor V,Deinhardt K</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to show that different markers of UPR are not changed at the late stage of any of the human tauopathies investigated. Interestingly, UPR signatures were often observed in non-demented controls.</div> <div itemprodp="datePublished">Sat Apr 30 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34856436"> <div itemprop="name">The metabolic signaling of the nucleoredoxin-like 2 gene supports brain function.</div> </a> <div itemprop="about">Redox biology</div> <div itemprop="author">Jaillard C,Ouechtati F,Clérin E,Millet-Puel G,Corsi M,Aït-Ali N,Blond F,Chevy Q,Gales L,Farinelli M,Dalkara D,Sahel JA,Portais JC,Poncer JC,Léveillard T</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to investigate the link between NXNL2 and tauopathies.</div> <div itemprodp="datePublished">Thu Nov 25 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34320462"> <div itemprop="name">Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Evans AK,Park HH,Saw NL,Singhal K,Ogawa G,Leib RD,Shamloo M</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to examine effects of age and acute beta-blocker administration on LC and hippocampus pathology, neuroinflammation and learning and memory behavior in mice.</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34320462"> <div itemprop="name">Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Evans AK,Park HH,Saw NL,Singhal K,Ogawa G,Leib RD,Shamloo M</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to examine effects of age and acute beta-blocker administration on LC and hippocampus pathology, neuroinflammation and learning and memory behavior in mice.</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34483889"> <div itemprop="name">IntelliCage Automated Behavioral Phenotyping Reveals Behavior Deficits in the 3xTg-AD Mouse Model of Alzheimer's Disease Associated With Brain Weight.</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Winslow W,McDonough I,Tallino S,Decker A,Vural AS,Velazquez R</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to examine d the behavioral performance of 3xTg-AD mice in the IntelliCage o study mechanisms of pathogenesis and connect these mechanisms with cognitive decline.</div> <div itemprodp="datePublished">Thu Apr 14 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33762004"> <div itemprop="name">Early alterations of neurovascular unit in the retina in mouse models of tauopathy.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Xia F,Ha Y,Shi S,Li Y,Li S,Luisi J,Kayed R,Motamedi M,Liu H,Zhang W</div> <div itemprop="description">MN1020 was used in Immunohistochemistry (Frozen) to study molecular mechanisms of neurodegeneration.</div> <div itemprodp="datePublished">Wed Mar 24 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34108219"> <div itemprop="name">Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Cornblath EJ,Li HL,Changolkar L,Zhang B,Brown HJ,Gathagan RJ,Olufemi MF,Trojanowski JQ,Bassett DS,Lee VMY,Henderson MX</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study tau pathology spread in the brains of nontransgenic mice with Alzheimer's disease tau.</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34187585"> <div itemprop="name">Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Kahriman A,Bouley J,Smith TW,Bosco DA,Woerman AL,Henninger N</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to compare the mouse closed-head traumatic brain injury model with human traumatic brain injury-associated tauopathy.</div> <div itemprodp="datePublished">Tue Jun 29 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34678069"> <div itemprop="name">Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Sato H,Takado Y,Toyoda S,Tsukamoto-Yasui M,Minatohara K,Takuwa H,Urushihata T,Takahashi M,Shimojo M,Ono M,Maeda J,Orihara A,Sahara N,Aoki I,Karakawa S,Isokawa M,Kawasaki N,Kawasaki M,Ueno S,Kanda M,Nishimura M,Suzuki K,Mitsui A,Nagao K,Kitamura A,Higuchi M</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to show that a low-protein diet resulted in down-regulated expression of synaptic components.</div> <div itemprodp="datePublished">Fri Oct 22 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34678069"> <div itemprop="name">Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Sato H,Takado Y,Toyoda S,Tsukamoto-Yasui M,Minatohara K,Takuwa H,Urushihata T,Takahashi M,Shimojo M,Ono M,Maeda J,Orihara A,Sahara N,Aoki I,Karakawa S,Isokawa M,Kawasaki N,Kawasaki M,Ueno S,Kanda M,Nishimura M,Suzuki K,Mitsui A,Nagao K,Kitamura A,Higuchi M</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to show that a low-protein diet resulted in down-regulated expression of synaptic components.</div> <div itemprodp="datePublished">Fri Oct 22 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33712082"> <div itemprop="name">Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Miller LVC,Mukadam AS,Durrant CS,Vaysburd MJ,Katsinelos T,Tuck BJ,Sanford S,Sheppard O,Knox C,Cheng S,James LC,Coleman MP,McEwan WA</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to ask whether tau assemblies share with classical pathogens the characteristic of particulate behaviour.</div> <div itemprodp="datePublished">Fri Mar 12 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34215303"> <div itemprop="name">SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease.</div> </a> <div itemprop="about">Molecular neurodegeneration</div> <div itemprop="author">Bichmann M,Prat Oriol N,Ercan-Herbst E,Schöndorf DC,Gomez Ramos B,Schwärzler V,Neu M,Schlüter A,Wang X,Jin L,Hu C,Tian Y,Ried JS,Haberkant P,Gasparini L,Ehrnhoefer DE</div> <div itemprop="description">MN1020 was used in ELISA to demonstrate that methylated Tau levels increase with Tau pathology stage in human AD samples as well as in a mouse model of Tauopathy.</div> <div itemprodp="datePublished">Fri Jul 02 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33648608"> <div itemprop="name">Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Perez Garcia G,De Gasperi R,Gama Sosa MA,Perez GM,Otero-Pagan A,Pryor D,Abutarboush R,Kawoos U,Hof PR,Dickstein DL,Cook DG,Gandy S,Ahlers ST,Elder GA</div> <div itemprop="description">MN1020 was used in Western Blotting to test the hypothesis that region-specific patterns of Thr181 phosphorylation correlate with behavioral measures also previously determined and reported in the same animals.</div> <div itemprodp="datePublished">Mon Mar 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34381050"> <div itemprop="name">The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Yuste-Checa P,Trinkaus VA,Riera-Tur I,Imamoglu R,Schaller TF,Wang H,Dudanova I,Hipp MS,Bracher A,Hartl FU</div> <div itemprop="description">MN1020 was used in Western Blot, Immunocytochemistry to conclude that upregulation of Clusterin, as observed in AD patients, may enhance Tau seeding and possibly accelerate the spreading of Tau pathology.</div> <div itemprodp="datePublished">Wed Aug 11 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34381050"> <div itemprop="name">The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Yuste-Checa P,Trinkaus VA,Riera-Tur I,Imamoglu R,Schaller TF,Wang H,Dudanova I,Hipp MS,Bracher A,Hartl FU</div> <div itemprop="description">MN1020 was used in Western Blot, Immunocytochemistry to conclude that upregulation of Clusterin, as observed in AD patients, may enhance Tau seeding and possibly accelerate the spreading of Tau pathology.</div> <div itemprodp="datePublished">Wed Aug 11 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35002279"> <div itemprop="name">Dysregulation of the Retromer Complex in Brain Endothelial Cells Results in Accumulation of Phosphorylated Tau.</div> </a> <div itemprop="about">Journal of inflammation research</div> <div itemprop="author">Filippone A,Smith T,Pratico D</div> <div itemprop="description">MN1020 was used in Western Blot to demonstrate that in brain endothelial cells retromer complex dysfunction by influencing endosome-lysosome degradation pathways results in altered proteostasis.</div> <div itemprodp="datePublished">Sat Jul 16 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33452414"> <div itemprop="name">Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Shin J,Park S,Lee H,Kim Y</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to reveal that, in addition to amyloid plaques, 5XFAD mice express ThS-positive phospho-tau (p-tau) aggregates.</div> <div itemprodp="datePublished">Fri Jan 15 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34674762"> <div itemprop="name">Deep learning reveals disease-specific signatures of white matter pathology in tauopathies.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Vega AR,Chkheidze R,Jarmale V,Shang P,Foong C,Diamond MI,White CL,Rajaram S</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to suggest that tau pathology in white matter is informative, disease-specific, and linked to gray matter pathology.</div> <div itemprodp="datePublished">Thu Oct 21 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33504364"> <div itemprop="name">Erythropoietin-derived peptide treatment reduced neurological deficit and neuropathological changes in a mouse model of tauopathy.</div> </a> <div itemprop="about">Alzheimer's research & therapy</div> <div itemprop="author">Choi YB,Dunn-Meynell AA,Marchese M,Blumberg BM,Gaindh D,Dowling PC,Lu W</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to investigate the effect of chronic JM4 treatment on the PS19 mouse that carries the P301S mutant human tau gene, linked to a form of frontotemporal dementia.</div> <div itemprodp="datePublished">Wed Jan 27 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33504364"> <div itemprop="name">Erythropoietin-derived peptide treatment reduced neurological deficit and neuropathological changes in a mouse model of tauopathy.</div> </a> <div itemprop="about">Alzheimer's research & therapy</div> <div itemprop="author">Choi YB,Dunn-Meynell AA,Marchese M,Blumberg BM,Gaindh D,Dowling PC,Lu W</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to investigate the effect of chronic JM4 treatment on the PS19 mouse that carries the P301S mutant human tau gene, linked to a form of frontotemporal dementia.</div> <div itemprodp="datePublished">Wed Jan 27 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33446720"> <div itemprop="name">Spatial memory deficiency early in 6xTg Alzheimer's disease mouse model.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Kang S,Kim J,Chang KA</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to develope and evaluate a novel AD mouse model (6xTg-AD, 6xTg) by crossbreeding 5xFAD mice with mice expressing mutant (P301L) tau protein (MAPT).</div> <div itemprodp="datePublished">Thu Jan 14 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33895869"> <div itemprop="name">ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's disease.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Kang SS,Ahn EH,Liu X,Bryson M,Miller GW,Weinshenker D,Ye K</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that ApoE4 selectively binds to the vesicular monoamine transporter 2 (VMAT2) and inhibits neurotransmitter uptake and that ApoE4 exacerbates Tau neurotoxicity by increasing VMAT2 vesicle leakage and facilitating AEP-mediated Tau proteolytic cleavage in the LC via DOPEGAL.</div> <div itemprodp="datePublished">Thu Jul 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34689831"> <div itemprop="name">Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Ravikumar S,Wisse LEM,Lim S,Ittyerah R,Xie L,Bedard ML,Das SR,Lee EB,Tisdall MD,Prabhakaran K,Lane J,Detre JA,Mizsei G,Trojanowski JQ,Robinson JL,Schuck T,Grossman M,Artacho-Pérula E,de Onzoño Martin MMI,Del Mar Arroyo Jiménez M,Muñoz M,Romero FJM,Del Pilar Marcos Rabal M,Sánchez SC,González JCD,de la Rosa Prieto C,Parada MC,Irwin DJ,Wolk DA,Insausti R,Yushkevich PA</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to find strong associations between tau pathology and thickness in the ERC, SRLM and the subiculum/cornu ammonis 1 (CA1) subfields of the hippocampus, consistent with early Braak stages.</div> <div itemprodp="datePublished">Sun Oct 24 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34469725"> <div itemprop="name">Long-term depression links amyloid-β to the pathological hyperphosphorylation of tau.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Taylor HBC,Emptage NJ,Jeans AF</div> <div itemprop="description">MN1020 was used in Western Blotting to study that an Aβo-mediated increase in glutamate release probability causes enhancement of synaptically evoked NMDAR dependent long-term depression.</div> <div itemprodp="datePublished">Tue Aug 31 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33980987"> <div itemprop="name">The anesthetic sevoflurane induces tau trafficking from neurons to microglia.</div> </a> <div itemprop="about">Communications biology</div> <div itemprop="author">Dong Y,Liang F,Huang L,Fang F,Yang G,Tanzi RE,Zhang Y,Quan Q,Xie Z</div> <div itemprop="description">MN1020 was used in Western Blotting to assess mice and neurons treated with anesthetics sevoflurane and desflurane, and apply nanobeam-sensor technology, an ultrasensitive method, to measure tau/p-tau amounts.</div> <div itemprodp="datePublished">Wed May 12 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34203256"> <div itemprop="name">Oral Pathogenic Bacteria-Inducing Neurodegenerative Microgliosis in Human Neural Cell Platform.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Tran VTA,Kang YJ,Kim HK,Kim HR,Cho H</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that the mouth-brain axis may contribute to the pathogenesis of AD.</div> <div itemprodp="datePublished">Mon Jun 28 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34200859"> <div itemprop="name">Bisavenathramide Analogues as Nrf2 Inductors and Neuroprotectors in In Vitro Models of Oxidative Stress and Hyperphosphorylation.</div> </a> <div itemprop="about">Antioxidants (Basel, Switzerland)</div> <div itemprop="author">Cores Á,Abril S,Michalska P,Duarte P,Olives AI,Martín MA,Villacampa M,León R,Menéndez JC</div> <div itemprop="description">MN1020 was used in Immunocytochemistry to describe the synthesis of a library of derivatives of the 4-arylmethylen-2-pyrrolin-5-one framework by sequential application of a three-component reaction of primary amines, β-dicarbonyl compounds, and α-haloketones and a Knoevenagel condensation.</div> <div itemprodp="datePublished">Thu Jun 10 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35140584"> <div itemprop="name">Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease.</div> </a> <div itemprop="about">Frontiers in neuroscience</div> <div itemprop="author">Javonillo DI,Tran KM,Phan J,Hingco E,Kramár EA,da Cunha C,Forner S,Kawauchi S,Milinkeviciute G,Gomez-Arboledas A,Neumann J,Banh CE,Huynh M,Matheos DP,Rezaie N,Alcantara JA,Mortazavi A,Wood MA,Tenner AJ,MacGregor GR,Green KN,LaFerla FM</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to demonstrate the utility of a characterization pipeline that generates robust and standardized information relevant to investigating and comparing disease etiologies of current and future models of AD.</div> <div itemprodp="datePublished">Sat Dec 17 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34575885"> <div itemprop="name">Behavioural Functions and Cerebral Blood Flow in a P301S Tauopathy Mouse Model: A Time-Course Study.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Ahmad F,Mein H,Jing Y,Zhang H,Liu P</div> <div itemprop="description">MN1020 was used in Western Blot to investigate how behavioural functions, resting cerebral blood flow (CBF) and tau pathology change in PS19 mice at 2, 4, 6, 8 and 12 months of age in a single study under one experimental condition, allowing for the cumulative assessment of age- and genotype-dependent changes.</div> <div itemprodp="datePublished">Wed Sep 08 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34009663"> <div itemprop="name">Application of deep learning to understand resilience to Alzheimer's disease pathology.</div> </a> <div itemprop="about">Brain pathology (Zurich, Switzerland)</div> <div itemprop="author">Lee CS,Latimer CS,Henriksen JC,Blazes M,Larson EB,Crane PK,Keene CD,Lee AY</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to suggest that the burden of NFTs is more strongly associated with cognitive impairment than the more diffuse neuritic tau commonly seen with tangle pathology and suggest that additional factors may underlie resilience mechanisms defined by traditional means.</div> <div itemprodp="datePublished">Mon Nov 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33832546"> <div itemprop="name">Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Martinez-Valbuena I,Valenti-Azcarate R,Amat-Villegas I,Marcilla I,Marti-Andres G,Caballero MC,Riverol M,Tuñon MT,Fraser PE,Luquin MR</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to show that the involvement of amylin, pancreatic α-synuclein, Aβ, PrP and tau in the complex pathophysiology of type two diabetes and in the appearance of insulin resistance in Alzheimer's and Parkinson's disease.</div> <div itemprodp="datePublished">Thu Apr 08 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34078905"> <div itemprop="name">UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Subramanian M,Hyeon SJ,Das T,Suh YS,Kim YK,Lee JS,Song EJ,Ryu H,Yu K</div> <div itemprop="description">MN1020 was used in Western Blot to demonstrate that UBE4B, a miR-9 target gene, promotes autophagy-mediated Tau degradation together with STUB1, and is thus an innovative therapeutic approach for AD.</div> <div itemprodp="datePublished">Wed Jun 02 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34948096"> <div itemprop="name">Extracellular Prion Protein Aggregates in Nine Gerstmann-Sträussler-Scheinker Syndrome Subjects with Mutation P102L: A Micromorphological Study and Comparison with Literature Data.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Jankovska N,Matej R,Olejar T</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study GSS plaques' micromorphology and protein composition. Found small, condensed plaques dominate; dystrophic neuritic changes with tau or Aβ rare and unrelated to GSS development.</div> <div itemprodp="datePublished">Fri Dec 10 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35531351"> <div itemprop="name">Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology.</div> </a> <div itemprop="about">Nature aging</div> <div itemprop="author">Dehkordi SK,Walker J,Sah E,Bennett E,Atrian F,Frost B,Woost B,Bennett RE,Orr TC,Zhou Y,Andhey PS,Colonna M,Sudmant PH,Xu P,Wang M,Zhang B,Zare H,Orr ME</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to show that CDKN2D/p19-expressing neurons with NFTs represent a unique cellular population in human AD with a senescence phenotype.</div> <div itemprodp="datePublished">Wed Dec 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34955756"> <div itemprop="name">Layer-Specific Vesicular Glutamate Transporter 1 Immunofluorescence Levels Delineate All Layers of the Human Hippocampus Including the <i>Stratum lucidum</i>.</div> </a> <div itemprop="about">Frontiers in cellular neuroscience</div> <div itemprop="author">Woelfle S,Boeckers TM</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to propose the vesicular glutamate transporter 1 (VGLUT1) as a molecular marker for the CA3 region.</div> <div itemprodp="datePublished">Tue Dec 28 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33822892"> <div itemprop="name">Identification of multiple system atrophy mimicking Parkinson's disease or progressive supranuclear palsy.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Miki Y,Tsushima E,Foti SC,Strand KM,Asi YT,Yamamoto AK,Bettencourt C,Oliveira MCB,De Pablo-Fernández E,Jaunmuktane Z,Lees AJ,Wakabayashi K,Warner TT,Quinn N,Holton JL,Ling H</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-paraffin to develop decision tree algorithms with combinations of clinical pointers to differentiate clinically atypical cases of multiple system atrophy from Parkinson's disease or progressive supranuclear palsy.</div> <div itemprodp="datePublished">Fri May 07 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31649329"> <div itemprop="name">Initiation of Parkinson's disease from gut to brain by δ-secretase.</div> </a> <div itemprop="about">Cell research</div> <div itemprop="author">Ahn EH,Kang SS,Liu X,Chen G,Zhang Z,Chandrasekharan B,Alam AM,Neish AS,Cao X,Ye K</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to conclude that δ-secretase plays a crucial role in initiating PD pathology progression from the ENS to the CNS.</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31649329"> <div itemprop="name">Initiation of Parkinson's disease from gut to brain by δ-secretase.</div> </a> <div itemprop="about">Cell research</div> <div itemprop="author">Ahn EH,Kang SS,Liu X,Chen G,Zhang Z,Chandrasekharan B,Alam AM,Neish AS,Cao X,Ye K</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to conclude that δ-secretase plays a crucial role in initiating PD pathology progression from the ENS to the CNS.</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32383020"> <div itemprop="name">Distribution patterns of tau pathology in progressive supranuclear palsy.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Kovacs GG,Lukic MJ,Irwin DJ,Arzberger T,Respondek G,Lee EB,Coughlin D,Giese A,Grossman M,Kurz C,McMillan CT,Gelpi E,Compta Y,van Swieten JC,Laat LD,Troakes C,Al-Sarraj S,Robinson JL,Roeber S,Xie SX,Lee VM,Trojanowski JQ,Höglinger GU</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to determine whether or not sequential distribution patterns can be recognized for progressive supranuclear palsy pathology.</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32385496"> <div itemprop="name">Hippocampal α-synuclein pathology correlates with memory impairment in multiple system atrophy.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Miki Y,Foti SC,Hansen D,Strand KM,Asi YT,Tsushima E,Jaunmuktane Z,Lees AJ,Warner TT,Quinn N,Ling H,Holton JL</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to provide evidence that neuronal cytoplasmic inclusion burden in the hippocampus and parahippocampus is associated with the occurrence of memory impairment in multiple system atrophy.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32812023"> <div itemprop="name">Phosphorylated tau interactome in the human Alzheimer's disease brain.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Drummond E,Pires G,MacMurray C,Askenazi M,Nayak S,Bourdon M,Safar J,Ueberheide B,Wisniewski T</div> <div itemprop="description">MN1020 was used in Immunohistochemistry (Paraffin) to determine the phosphorylated tau interactome.</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32179883"> <div itemprop="name">Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Bevan-Jones WR,Cope TE,Jones PS,Kaalund SS,Passamonti L,Allinson K,Green O,Hong YT,Fryer TD,Arnold R,Coles JP,Aigbirhio FI,Larner AJ,Patterson K,O'Brien JT,Rowe JB</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate how neuroinflammation relates to the localization of tau and TDP-43 pathology, and to the heterogeneity of clinical disease.</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32406202"> <div itemprop="name">Modeling Controlled Cortical Impact Injury in 3D Brain-Like Tissue Cultures.</div> </a> <div itemprop="about">Advanced healthcare materials</div> <div itemprop="author">Liaudanskaya V,Chung JY,Mizzoni C,Rouleau N,Berk AN,Wu L,Turner JA,Georgakoudi I,Whalen MJ,Nieland TJF,Kaplan DL</div> <div itemprop="description">MN1020 was used in Western Blot to develop a 3D in vitro contusion model using murine cortical neurones, to study traumatic brain injury.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32815315"> <div itemprop="name">Tau-induced upregulation of C/EBPβ-TRPC1-SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration.</div> </a> <div itemprop="about">Aging cell</div> <div itemprop="author">Ye J,Yin Y,Yin Y,Zhang H,Wan H,Wang L,Zuo Y,Gao D,Li M,Li J,Liu Y,Ke D,Wang JZ</div> <div itemprop="description">MN1020 was used in Immunocytochemistry to show that increasing intracellular tau could upregulate mRNA and protein levels of TRPC1 (transient receptor potential channel 1) with an activated store-operated calcium entry (SOCE), an increased intraneuronal steady-state [Ca2+ ]i , an enhanced endoplasmic reticulum (ER) stress, an imbalanced protein kinases and phosphatase, and an aggravated tauopathy.</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33269098"> <div itemprop="name">Reparative Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor in Aged APP/PS1 Mice.</div> </a> <div itemprop="about">Aging and disease</div> <div itemprop="author">Guo X,Liu Y,Morgan D,Zhao LR</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to determine the therapeutic efficacy of stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) (SCF+G-CSF) in aged APPswe/PS1dE9 (APP/PS1) mice.</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32701572"> <div itemprop="name">Tau Contributes to Sevoflurane-induced Neurocognitive Impairment in Neonatal Mice.</div> </a> <div itemprop="about">Anesthesiology</div> <div itemprop="author">Yu Y,Yang Y,Tan H,Boukhali M,Khatri A,Yu Y,Hua F,Liu L,Li M,Yang G,Dong Y,Zhang Y,Haas W,Xie Z</div> <div itemprop="description">MN1020 was used in Western Blotting to test the hypothesis that differences in brain Tau amounts and in the activity of mitochondria-adenosine triphosphate (ATP)-Nuak1-Tau cascade between the neonatal and adult mice contribute to the age-dependent effects of sevoflurane on cognitive function.</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32044365"> <div itemprop="name">Effect of Melatonin on Tau aggregation and Tau-mediated cell surface morphology.</div> </a> <div itemprop="about">International journal of biological macromolecules</div> <div itemprop="author">Das R,Balmik AA,Chinnathambi S</div> <div itemprop="description">MN1020 was used in Immunocytochemistry-immunoflourescence to suggest that Melatonin administration shows mild anti-aggregation and cytoprotective effects.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31935519"> <div itemprop="name">Correlative x-ray phase-contrast tomography and histology of human brain tissue affected by Alzheimer's disease.</div> </a> <div itemprop="about">NeuroImage</div> <div itemprop="author">Töpperwien M,van der Meer F,Stadelmann C,Salditt T</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to use x-ray phase-contrast tomography to obtain three-dimensional reconstructions of human hippocampal tissue affected by Alzheimer's disease.</div> <div itemprodp="datePublished">Wed Apr 15 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33344697"> <div itemprop="name">Reproductive status impact on tau phosphorylation induced by chronic stress.</div> </a> <div itemprop="about">Neurobiology of stress</div> <div itemprop="author">Muñoz-Mayorga D,Rissman RA,Morales T</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to test the hypothesis that reproductive status can impact hippocampal pTau induced by chronic stress.</div> <div itemprodp="datePublished">Sun Nov 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32961270"> <div itemprop="name">Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R.</div> </a> <div itemprop="about">Neurobiology of disease</div> <div itemprop="author">Sandberg A,Ling H,Gearing M,Dombroski B,Cantwell L,R'Bibo L,Levey A,Schellenberg GD,Hardy J,Wood N,Fernius J,Nyström S,Svensson S,Thor S,Hammarström P,Revesz T,Mok KY</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to suggest that the G273R mutation induces a shift in pool of 4R tau by lower F-actin affinity, alters the conformation of MT bound 4R tau, while increasing chaperoning of 3R tau by binding stronger to F-actin.</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31822518"> <div itemprop="name">Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Fan Q,He W,Gayen M,Benoit MR,Luo X,Hu X,Yan R</div> <div itemprop="description">MN1020 was used in Western Blot to explore the potential of CX3CL1 as a target for Alzheimer's disease or related neurodegenerative disease.</div> <div itemprodp="datePublished">Wed Jan 29 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32265258"> <div itemprop="name">Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Shimojo M,Takuwa H,Takado Y,Tokunaga M,Tsukamoto S,Minatohara K,Ono M,Seki C,Maeda J,Urushihata T,Minamihisamatsu T,Aoki I,Kawamura K,Zhang MR,Suhara T,Sahara N,Higuchi M</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to indicate that selective degeneration of inhibitory synapse with hyperexcitability in the cortical circuit constitutes the critical early pathophysiology of tauopathy in mice.</div> <div itemprodp="datePublished">Wed Apr 22 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32265258"> <div itemprop="name">Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Shimojo M,Takuwa H,Takado Y,Tokunaga M,Tsukamoto S,Minatohara K,Ono M,Seki C,Maeda J,Urushihata T,Minamihisamatsu T,Aoki I,Kawamura K,Zhang MR,Suhara T,Sahara N,Higuchi M</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to indicate that selective degeneration of inhibitory synapse with hyperexcitability in the cortical circuit constitutes the critical early pathophysiology of tauopathy in mice.</div> <div itemprodp="datePublished">Wed Apr 22 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33192286"> <div itemprop="name">Profiling Microglia From Alzheimer's Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue.</div> </a> <div itemprop="about">Frontiers in molecular neuroscience</div> <div itemprop="author">Alsema AM,Jiang Q,Kracht L,Gerrits E,Dubbelaar ML,Miedema A,Brouwer N,Hol EM,Middeldorp J,van Dijk R,Woodbury M,Wachter A,Xi S,Möller T,Biber KP,Kooistra SM,Boddeke EWGM,Eggen BJL</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to identify seven human microglial subpopulations with heterogeneity in gene expression.</div> <div itemprodp="datePublished">Sun Nov 12 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33681188"> <div itemprop="name">Targeted Reducing of Tauopathy Alleviates Epileptic Seizures and Spatial Memory Impairment in an Optogenetically Inducible Mouse Model of Epilepsy.</div> </a> <div itemprop="about">Frontiers in cell and developmental biology</div> <div itemprop="author">Gao Y,Zheng J,Jiang T,Pi G,Sun F,Xiong R,Wang W,Wu D,Li S,Lei H,Yu H,Zhou Q,Yang Y,Zhang H,Wang JZ</div> <div itemprop="description">MN1020 was used in Western Blot, Immunocytochemistry to prove that abnormal tau accumulation plays a pivotal role in the epileptic seizures and the epilepsy-associated spatial memory impairments, which provides new molecular target for the therapeutics.</div> <div itemprodp="datePublished">Wed Mar 10 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33681188"> <div itemprop="name">Targeted Reducing of Tauopathy Alleviates Epileptic Seizures and Spatial Memory Impairment in an Optogenetically Inducible Mouse Model of Epilepsy.</div> </a> <div itemprop="about">Frontiers in cell and developmental biology</div> <div itemprop="author">Gao Y,Zheng J,Jiang T,Pi G,Sun F,Xiong R,Wang W,Wu D,Li S,Lei H,Yu H,Zhou Q,Yang Y,Zhang H,Wang JZ</div> <div itemprop="description">MN1020 was used in Western Blot, Immunocytochemistry to prove that abnormal tau accumulation plays a pivotal role in the epileptic seizures and the epilepsy-associated spatial memory impairments, which provides new molecular target for the therapeutics.</div> <div itemprodp="datePublished">Wed Mar 10 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31903524"> <div itemprop="name">Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy.</div> </a> <div itemprop="about">Molecular neurobiology</div> <div itemprop="author">Koller EJ,Gonzalez De La Cruz E,Weinrich M,Williams T,Cruz PE,Ryu D,Golde TE,Sullivan PM,Lewis J,Borchelt DR,Chakrabarty P</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to indicate that over-expression of APOE4 in neurons, using an AAV-mediated approache, is not sufficient to accelerate or otherwise alter the inherent tau pathology that occurs in mice overexpressing mutant human tau.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31951013"> <div itemprop="name">Correcting abnormalities in miR-124/PTPN1 signaling rescues tau pathology in Alzheimer's disease.</div> </a> <div itemprop="about">Journal of neurochemistry</div> <div itemprop="author">Hou TY,Zhou Y,Zhu LS,Wang X,Pang P,Wang DQ,Liuyang ZY,Man H,Lu Y,Zhu LQ,Liu D</div> <div itemprop="description">MN1020 was used in Western Blot to investigate the potential role of miR-124/PTPN1 in the tau pathology of AD.</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32500377"> <div itemprop="name">Tau Accumulation via Reduced Autophagy Mediates GGGGCC Repeat Expansion-Induced Neurodegeneration in Drosophila Model of ALS.</div> </a> <div itemprop="about">Neuroscience bulletin</div> <div itemprop="author">Wen X,An P,Li H,Zhou Z,Sun Y,Wang J,Ma L,Lu B</div> <div itemprop="description">MN1020 was used in Western Blotting to investigate the effect of reducing a tau protein homologue on neurodegeneration, motor performance and impairments.</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30797548"> <div itemprop="name">Genetic screening in early-onset Alzheimer's disease identified three novel presenilin mutations.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Wong TH,Seelaar H,Melhem S,Rozemuller AJM,van Swieten JC</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to identify new variants in the presenilin 1 and 2 genes implicated in early-onset Alzheimer's disease.</div> <div itemprodp="datePublished">Sat Feb 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32008854"> <div itemprop="name">Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">van Olst L,Verhaege D,Franssen M,Kamermans A,Roucourt B,Carmans S,Ytebrouck E,van der Pol SMA,Wever D,Popovic M,Vandenbroucke RE,Sobrino T,Schouten M,de Vries HE</div> <div itemprop="description">MN1020 was used in Western Blotting to address at which tauopathy stage neuroinflammation starts and to study the related microglial phenotype.</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31870644"> <div itemprop="name">Two pathologically confirmed cases of novel mutations in the MAPT gene causing frontotemporal dementia.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Shafei R,Woollacott IOC,Mummery CJ,Bocchetta M,Guerreiro R,Bras J,Warren JD,Lashley T,Jaunmuktane Z,Rohrer JD</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to describe 2 novel MAPT mutations, D252V and G389_I392del, each presenting in a patient with behavioral variant FTD and associated language and cognitive deficits.</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32497877"> <div itemprop="name">Isolation and characterization of antibody fragment selective for human Alzheimer's disease brain-derived tau variants.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Venkataraman L,He P,Schulz P,Sierks MR</div> <div itemprop="description">MN1020 was used in Immunoprecipitation to identify and explore 6 scFvs [Alzheimer's disease tau (ADT)-1 through 6] that are readily distinguished between Alzheimer's disease and control tissue and sera samples.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31691796"> <div itemprop="name">Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Guarascio R,Salih D,Yasvoina M,Edwards FA,Cheetham ME,van der Spuy J</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate if negative regulator of ubiquitin-like protein 1 plays a role in regulating the autophagy-lysosomal pathway when the ubiquitin proteasome system is compromised, thus contributing to the mechanisms targeting the removal of aggregation-prone proteins upon proteasomal impairment.</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31691796"> <div itemprop="name">Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Guarascio R,Salih D,Yasvoina M,Edwards FA,Cheetham ME,van der Spuy J</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate if negative regulator of ubiquitin-like protein 1 plays a role in regulating the autophagy-lysosomal pathway when the ubiquitin proteasome system is compromised, thus contributing to the mechanisms targeting the removal of aggregation-prone proteins upon proteasomal impairment.</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31691796"> <div itemprop="name">Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Guarascio R,Salih D,Yasvoina M,Edwards FA,Cheetham ME,van der Spuy J</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate if negative regulator of ubiquitin-like protein 1 plays a role in regulating the autophagy-lysosomal pathway when the ubiquitin proteasome system is compromised, thus contributing to the mechanisms targeting the removal of aggregation-prone proteins upon proteasomal impairment.</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32004818"> <div itemprop="name">Co-Existence of tau and α-synuclein pathology in fetal graft tissue at autopsy: A case report.</div> </a> <div itemprop="about">Parkinsonism & related disorders</div> <div itemprop="author">Ornelas AS,Adler CH,Serrano GE,Curry JR,Shill HA,Kopyov O,Beach TG</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to analyze fetal graft tissue at autopsy and demostrate 6 cases of α-synuclein pathology in PD patients, one case with both α-synuclein and tau pathology in a PD patient, and two cases of tau pathology within a Huntington's Disease patient..</div> <div itemprodp="datePublished">Sat Feb 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33014595"> <div itemprop="name">Detection of cerebral tauopathy in P301L mice using high-resolution large-field multifocal illumination fluorescence microscopy.</div> </a> <div itemprop="about">Biomedical optics express</div> <div itemprop="author">Ni R,Chen Z,Gerez JA,Shi G,Zhou Q,Riek R,Nilsson KPR,Razansky D,Klohs J</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to report a transcranial detection of tauopathy over the entire cortex of P301L tauopathy mice using large-field multifocal illumination (LMI) fluorescence microscopy technique and luminescent conjugated oligothiophenes.</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32542468"> <div itemprop="name">Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer's disease pathology: a clinicopathological study.</div> </a> <div itemprop="about">EJNMMI research</div> <div itemprop="author">Pontecorvo MJ,Keene CD,Beach TG,Montine TJ,Arora AK,Devous MD,Navitsky M,Kennedy I,Joshi AD,Lu M,Serrano GE,Sue LI,Intorcia AJ,Rose SE,Wilson A,Hellstern L,Coleman N,Flitter M,Aldea P,Fleisher AS,Mintun MA,Siderowf A</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to make a quantitative comparison of flortaucipir PET retention with pathological tau and β-amyloid across a range of brain regions at autopsy.</div> <div itemprodp="datePublished">Mon Jun 15 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32377738"> <div itemprop="name">Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Yang M,Lian N,Yu Y,Wang Y,Xie K,Yu Y</div> <div itemprop="description">MN1020 was used in Immunocytochemistry-immunoflourescence to reveal the role of ApoE in the pathogenesis of tau protein hyperphosphorylation and neuroinflammation enhancement caused by sevoflurane anesthesia, as well as the protective mechanism of CoQ10 in an anesthetic sevoflurane treatment model of primary mouse hippocampal neurons.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32377738"> <div itemprop="name">Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Yang M,Lian N,Yu Y,Wang Y,Xie K,Yu Y</div> <div itemprop="description">MN1020 was used in Immunocytochemistry-immunoflourescence to reveal the role of ApoE in the pathogenesis of tau protein hyperphosphorylation and neuroinflammation enhancement caused by sevoflurane anesthesia, as well as the protective mechanism of CoQ10 in an anesthetic sevoflurane treatment model of primary mouse hippocampal neurons.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31851313"> <div itemprop="name">Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Iacono D,Lee P,Edlow BL,Gray N,Fischl B,Kenney K,Lew HL,Lozanoff S,Liacouras P,Lichtenberger J,Dams-O'Connor K,Cifu D,Hinds SR,Perl DP</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to describe clinicopathologic findings in 4 military veterans with early-onset dementia (EOD) who had varying histories of blunt- and blast-TBI, cognitive decline, behavioral abnormalities, post-traumatic stress disorder, suicidal ideation, and suicide.</div> <div itemprodp="datePublished">Sat Feb 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32106300"> <div itemprop="name">Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Trejo-Lopez JA,Sorrentino ZA,Riffe CJ,Prokop S,Dickson DW,Yachnis AT,Giasson BI</div> <div itemprop="description">MN1020 was used in Western Blotting to provide utility in both research and diagnostic efforts.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32256561"> <div itemprop="name">Neuroprotection against Amyloid-<i>β</i>-Induced DNA Double-Strand Breaks Is Mediated by Multiple Retinoic Acid-Dependent Pathways.</div> </a> <div itemprop="about">Neural plasticity</div> <div itemprop="author">Colas J,Chessel N,Ouared A,Gruz-Gibelli E,Marin P,Herrmann FR,Savioz A</div> <div itemprop="description">MN1020 was used in Western Blot to show that RA can not only repair Aβ 1-42-induced DSBs but also prevent them via the RARα/β/γ and PPARβ/δ receptors.</div> <div itemprodp="datePublished">Wed Apr 07 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31273784"> <div itemprop="name">β-amyloid and tau pathology in the aging feline brain.</div> </a> <div itemprop="about">The Journal of comparative neurology</div> <div itemprop="author">Fiock KL,Smith JD,Crary JF,Hefti MM</div> <div itemprop="description">MN1020 was used in Immunohistochemistry (Paraffin) to propose that the development of β-amyloid and tau pathology in ageing domestic cats is similar to human Alzheimer's disease and could serve as a model.</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32327969"> <div itemprop="name">Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy.</div> </a> <div itemprop="about">Frontiers in neuroscience</div> <div itemprop="author">LeBlang CJ,Medalla M,Nicoletti NW,Hays EC,Zhao J,Shattuck J,Cruz AL,Wolozin B,Luebke JI</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to demonstrate that TIA1 plays an important role in the neuroimmune response to chronic stress in the form of tauopathy.</div> <div itemprodp="datePublished">Fri Nov 03 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33168021"> <div itemprop="name">Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques.</div> </a> <div itemprop="about">Molecular neurodegeneration</div> <div itemprop="author">Natunen T,Martiskainen H,Marttinen M,Gabbouj S,Koivisto H,Kemppainen S,Kaipainen S,Takalo M,Svobodová H,Leppänen L,Kemiläinen B,Ryhänen S,Kuulasmaa T,Rahunen E,Juutinen S,Mäkinen P,Miettinen P,Rauramaa T,Pihlajamäki J,Haapasalo A,Leinonen V,Tanila H,Hiltunen M</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to suggest that the diabetic phenotype in mice and humans mechanistically associates with abnormally reduced microglial responses to β-amyloid pathology and further suggest that AD and T2D share overlapping pathomechanisms, likely involving altered immune function in the brain.</div> <div itemprodp="datePublished">Tue Nov 10 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33076986"> <div itemprop="name">Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Perez-Rando M,Dujardin S,Bennett RE,Commins C,Nibhanupudy T,Hyman BT</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to suggest that tau propagation impacts neuronal functional integrity.</div> <div itemprodp="datePublished">Mon Oct 19 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32467226"> <div itemprop="name">Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Nachman E,Wentink AS,Madiona K,Bousset L,Katsinelos T,Allinson K,Kampinga H,McEwan WA,Jahn TR,Melki R,Mogk A,Bukau B,Nussbaum-Krammer C</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to show that an ATP-dependent human chaperone system disassembles Tau fibrils in vitro We found that this function is mediated by the core chaperone HSC70, assisted by specific cochaperones, in particular class B J-domain proteins and a heat shock protein 110 (Hsp110)-type nucleotide exchange factor (NEF).</div> <div itemprodp="datePublished">Fri Jul 10 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33199792"> <div itemprop="name">APOE4 genetic polymorphism results in impaired recovery in a repeated mild traumatic brain injury model and treatment with Bryostatin-1 improves outcomes.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Giarratana AO,Zheng C,Reddi S,Teng SL,Berger D,Adler D,Sullivan P,Thakker-Varia S,Alder J</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to demonstrate that APOE4 is a risk factor for poor outcomes after rmTBI and highlights how personalized therapeutics can be a powerful treatment option.</div> <div itemprodp="datePublished">Mon Nov 16 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32927795"> <div itemprop="name">Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Roda AR,Montoliu-Gaya L,Serra-Mir G,Villegas S</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to assess the effects of scFv-h3D6 on Aβ and tau pathologies in 22-month-old 3xTg-AD mice. Briefly, 3xTg-AD female mice were treated for 2 weeks with scFv-h3D6 and compared with 3xTg-AD and non-transgenic (NTg) mice treated with PBS..</div> <div itemprodp="datePublished">Thu Sep 10 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32585593"> <div itemprop="name">The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging.</div> </a> <div itemprop="about">iScience</div> <div itemprop="author">Wander CM,Tseng JH,Song S,Al Housseiny HA,Tart DS,Ajit A,Ian Shih YY,Lobrovich R,Song J,Meeker RB,Irwin DJ,Cohen TJ</div> <div itemprop="description">MN1020 was used in Western Blotting to supports neuroimmune dysfunction as a precipitating event in tau pathogenesis.</div> <div itemprodp="datePublished">Fri Jul 24 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32814048"> <div itemprop="name">Fyn Kinase Controls Tau Aggregation In Vivo.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Briner A,Götz J,Polanco JC</div> <div itemprop="description">MN1020 was used in Western Blot to identify Fyn as a key regulator of tau pathology independently of Aβ-induced toxicity.</div> <div itemprodp="datePublished">Tue Aug 18 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32426502"> <div itemprop="name">Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Bourdenx M,Nioche A,Dovero S,Arotcarena ML,Camus S,Porras G,Thiolat ML,Rougier NP,Prigent A,Aubert P,Bohic S,Sandt C,Laferrière F,Doudnikoff E,Kruse N,Mollenhauer B,Novello S,Morari M,Leste-Lasserre T,Damas IT,Goillandeau M,Perier C,Estrada C,Garcia-Carrillo N,Recasens A,Vaikath NN,El-Agnaf OMA,Herrero MT,Derkinderen P,Vila M,Obeso JA,Dehay B,Bezard E</div> <div itemprop="description">MN1020 was used in Dot blot to identify unique signatures of neurodegeneration in monkeys induced by distinct α-syn pathogenic structures derived from patients with Parkinson''s disease (PD).</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32034092"> <div itemprop="name">Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Crowe A,Henderson MJ,Anderson J,Titus SA,Zakharov A,Simeonov A,Buist A,Delay C,Moechars D,Trojanowski JQ,Lee VM,Brunden KR</div> <div itemprop="description">MN1020 was used in Western Blotting to suggest that neurons, the cells most affected by tau pathology in AD, are very suitable for screening for tau inclusion inhibitors.</div> <div itemprodp="datePublished">Fri Mar 20 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32183198"> <div itemprop="name">Tauopathy Analysis in P301S Mouse Model of Alzheimer Disease Immunized With DNA and MVA Poxvirus-Based Vaccines Expressing Human Full-Length 4R2N or 3RC Tau Proteins.</div> </a> <div itemprop="about">Vaccines</div> <div itemprop="author">García-Arriaza J,Marín MQ,Merchán-Rubira J,Mascaraque SM,Medina M,Ávila J,Hernández F,Esteban M</div> <div itemprop="description">MN1020 was used in Western Blot to present the generation and characterization of the first MVA vectors expressing human tau genes; the full-length 4R2N tau protein or a 3RC tau fragment containing 3 tubulin-binding motifs and the C-terminal region.</div> <div itemprodp="datePublished">Fri Mar 13 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32183198"> <div itemprop="name">Tauopathy Analysis in P301S Mouse Model of Alzheimer Disease Immunized With DNA and MVA Poxvirus-Based Vaccines Expressing Human Full-Length 4R2N or 3RC Tau Proteins.</div> </a> <div itemprop="about">Vaccines</div> <div itemprop="author">García-Arriaza J,Marín MQ,Merchán-Rubira J,Mascaraque SM,Medina M,Ávila J,Hernández F,Esteban M</div> <div itemprop="description">MN1020 was used in Western Blot to present the generation and characterization of the first MVA vectors expressing human tau genes; the full-length 4R2N tau protein or a 3RC tau fragment containing 3 tubulin-binding motifs and the C-terminal region.</div> <div itemprodp="datePublished">Fri Mar 13 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32019605"> <div itemprop="name">Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Kaalund SS,Passamonti L,Allinson KSJ,Murley AG,Robbins TW,Spillantini MG,Rowe JB</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to test the hypothesis that tau pathology and neuronal loss are associated with clinical heterogeneity and severity in progressive supranuclear palsy.</div> <div itemprodp="datePublished">Tue Feb 04 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32437347"> <div itemprop="name">Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer's disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca2+ dysregulation: Therapeutic implications.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Soto-Mercado V,Mendivil-Perez M,Velez-Pardo C,Lopera F,Jimenez-Del-Rio M</div> <div itemprop="description">MN1020 was used in Immunocytochemistry-immunoflourescence to demonstrate that FAD MSC-derived cholinergic neurons with the PSEN1 E280A mutation provide important clues for the identification of targetable pathological molecules.</div> <div itemprodp="datePublished">Wed Sep 09 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32679907"> <div itemprop="name">Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer's Disease Progression.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Nam E,Lee YB,Moon C,Chang KA</div> <div itemprop="description">MN1020 was used in Western Blotting to suggest that serum tau proteins, especially NEX tau proteins, are useful biomarkers for monitoring AD progression.</div> <div itemprodp="datePublished">Wed Jul 15 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32823945"> <div itemprop="name">Effects of Aerobic Exercise on Tau and Related Proteins in Rats with the Middle Cerebral Artery Occlusion.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Mankhong S,Kim S,Moon S,Lee KH,Jeon HE,Hwang BH,Beak JW,Joa KL,Kang JH</div> <div itemprop="description">MN1020 was used in Western Blotting to evaluate the effects of aerobic exercise on the phosphorylation and acetylation of tau and the expressions of tau-related proteins, after middle cerebral artery occlusion (MCAO) stroke.</div> <div itemprodp="datePublished">Fri Aug 14 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32219000"> <div itemprop="name">Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice.</div> </a> <div itemprop="about">NPJ vaccines</div> <div itemprop="author">Takeuchi H,Imamura K,Ji B,Tsukita K,Enami T,Takao K,Miyakawa T,Hasegawa M,Sahara N,Iwata N,Inoue M,Hara H,Tabira T,Ono M,Trojanowski JQ,Lee VM,Takahashi R,Suhara T,Higuchi M,Inoue H</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to determine that nasal drop tau vaccines induced tissue tau-immunoreactive antibody production and ameliorated cognitive impairment in frontotemporal lobar degeneration tauopathy model mice.</div> <div itemprodp="datePublished">Mon Aug 16 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32219000"> <div itemprop="name">Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice.</div> </a> <div itemprop="about">NPJ vaccines</div> <div itemprop="author">Takeuchi H,Imamura K,Ji B,Tsukita K,Enami T,Takao K,Miyakawa T,Hasegawa M,Sahara N,Iwata N,Inoue M,Hara H,Tabira T,Ono M,Trojanowski JQ,Lee VM,Takahashi R,Suhara T,Higuchi M,Inoue H</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to determine that nasal drop tau vaccines induced tissue tau-immunoreactive antibody production and ameliorated cognitive impairment in frontotemporal lobar degeneration tauopathy model mice.</div> <div itemprodp="datePublished">Mon Aug 16 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32219000"> <div itemprop="name">Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice.</div> </a> <div itemprop="about">NPJ vaccines</div> <div itemprop="author">Takeuchi H,Imamura K,Ji B,Tsukita K,Enami T,Takao K,Miyakawa T,Hasegawa M,Sahara N,Iwata N,Inoue M,Hara H,Tabira T,Ono M,Trojanowski JQ,Lee VM,Takahashi R,Suhara T,Higuchi M,Inoue H</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to determine that nasal drop tau vaccines induced tissue tau-immunoreactive antibody production and ameliorated cognitive impairment in frontotemporal lobar degeneration tauopathy model mice.</div> <div itemprodp="datePublished">Mon Aug 16 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31410926"> <div itemprop="name">Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease.</div> </a> <div itemprop="about">Brain pathology (Zurich, Switzerland)</div> <div itemprop="author">Lauterborn JC,Cox CD,Chan SW,Vanderklish PW,Lynch G,Gall CM</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate marked synaptic disturbances in two actin regulatory proteins in adult DS and AD brains, with greater effects in individuals with AD alone.</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33139712"> <div itemprop="name">APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Zhao J,Fu Y,Yamazaki Y,Ren Y,Davis MD,Liu CC,Lu W,Wang X,Chen K,Cherukuri Y,Jia L,Martens YA,Job L,Shue F,Nguyen TT,Younkin SG,Graff-Radford NR,Wszolek ZK,Brafman DA,Asmann YW,Ertekin-Taner N,Kanekiyo T,Bu G</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to suggest APOE4-related degenerative pathways contributing to AD pathogenesis, using human iPSC-organoids recapitulates APOE4-related phenotypes.</div> <div itemprodp="datePublished">Mon Nov 02 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33139712"> <div itemprop="name">APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Zhao J,Fu Y,Yamazaki Y,Ren Y,Davis MD,Liu CC,Lu W,Wang X,Chen K,Cherukuri Y,Jia L,Martens YA,Job L,Shue F,Nguyen TT,Younkin SG,Graff-Radford NR,Wszolek ZK,Brafman DA,Asmann YW,Ertekin-Taner N,Kanekiyo T,Bu G</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to suggest APOE4-related degenerative pathways contributing to AD pathogenesis, using human iPSC-organoids recapitulates APOE4-related phenotypes.</div> <div itemprodp="datePublished">Mon Nov 02 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33298440"> <div itemprop="name">Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Cao Q,Wang W,Williams JB,Yang F,Wang ZJ,Yan Z</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to find a novel epigenetic mechanism and a potential therapeutic strategy for AD and related neurodegenerative disorders.</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33298440"> <div itemprop="name">Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Cao Q,Wang W,Williams JB,Yang F,Wang ZJ,Yan Z</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to find a novel epigenetic mechanism and a potential therapeutic strategy for AD and related neurodegenerative disorders.</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31581367"> <div itemprop="name">Yeast surface display of full-length human microtubule-associated protein tau.</div> </a> <div itemprop="about">Biotechnology progress</div> <div itemprop="author">Wang S,Cho YK</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot, Flow Cytometry to show that yeast-displayed tau enables robust measurement of protein interactions and is of particular interest for characterizing conformational change.</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33311478"> <div itemprop="name">Delta-secretase triggers Alzheimer's disease pathologies in wild-type hAPP/hMAPT double transgenic mice.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Wu Z,Liu X,Cheng L,Ye K</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to establish a new mouse Alzheimer's disease model with both human wild-type amyloid-β precursor protein and Tau.</div> <div itemprodp="datePublished">Sat Dec 12 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33311478"> <div itemprop="name">Delta-secretase triggers Alzheimer's disease pathologies in wild-type hAPP/hMAPT double transgenic mice.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Wu Z,Liu X,Cheng L,Ye K</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to establish a new mouse Alzheimer's disease model with both human wild-type amyloid-β precursor protein and Tau.</div> <div itemprodp="datePublished">Sat Dec 12 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32858147"> <div itemprop="name">Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in.</div> </a> <div itemprop="about">Neurobiology of disease</div> <div itemprop="author">Chiasseu M,Fesharaki-Zadeh A,Saito T,Saido TC,Strittmatter SM</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to reveal that rmCHI enhances accumulation of amyloid-β and hyperphosphorylated tau inclusions, as well as neuroinflammation in AppNL-F/NL-F mice.</div> <div itemprodp="datePublished">Sun Nov 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32366836"> <div itemprop="name">Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer's disease, progressive supranuclear palsy and dementia with Lewy bodies.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Puangmalai N,Bhatt N,Montalbano M,Sengupta U,Gaikwad S,Ventura F,McAllen S,Ellsworth A,Garcia S,Kayed R</div> <div itemprop="description">MN1020 was used in Western Blotting to demonstrate that the HSPG-mediated pathway regulates internalization of BDTOs from AD and DLB, while HSPG-mediated and other alternative pathways are involved in the internalization of PSP-derived tau oligomers.</div> <div itemprodp="datePublished">Mon May 04 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33228809"> <div itemprop="name">Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">McMillan P,Wheeler J,Gatlin RE,Taylor L,Strovas T,Baum M,Bird TD,Latimer C,Keene CD,Kraemer BC,Liachko NF</div> <div itemprop="description">MN1020 was used in Immunohistochemistry (Paraffin) to characterize the consequences of neuronal TTBK1 upregulation in adult brains.</div> <div itemprodp="datePublished">Mon Nov 23 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32645028"> <div itemprop="name">Correlation of pyroglutamate amyloid β and ptau Ser202/Thr205 levels in Alzheimer's disease and related murine models.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Neddens J,Daurer M,Flunkert S,Beutl K,Loeffler T,Walker L,Attems J,Hutter-Paier B</div> <div itemprop="description">MN1020 was used in Immunocytochemistry to show that Aβ-pE(3) and ptau Ser202/Thr205 levels strongly correlate in human as well as murine tissues, suggesting that tau phosphorylation might be amplified by Aβ-pE(3).</div> <div itemprodp="datePublished">Mon Sep 07 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32740999"> <div itemprop="name">Effects of IgLON5 Antibodies on Neuronal Cytoskeleton: A Link between Autoimmunity and Neurodegeneration.</div> </a> <div itemprop="about">Annals of neurology</div> <div itemprop="author">Landa J,Gaig C,Plagumà J,Saiz A,Antonell A,Sanchez-Valle R,Dalmau J,Graus F,Sabater L</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to suggest that IgLON5 IgG, unlike other cell-surface antibodies, disrupts neuronal cytoskeleton maintenance, providing a link between autoimmunity and neurodegeneration.</div> <div itemprodp="datePublished">Sun Nov 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31964406"> <div itemprop="name">A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles.</div> </a> <div itemprop="about">Molecular neurodegeneration</div> <div itemprop="author">Li JG,Chiu J,Ramanjulu M,Blass BE,Praticò D</div> <div itemprop="description">MN1020 was used in Immunohistochemistry and Western Blotting to demonstrate that vacuolar protein sorting 35 genetic manipulation modulates the phenotype of mouse models of Alzheimer's disease.</div> <div itemprodp="datePublished">Wed Jan 22 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31964406"> <div itemprop="name">A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles.</div> </a> <div itemprop="about">Molecular neurodegeneration</div> <div itemprop="author">Li JG,Chiu J,Ramanjulu M,Blass BE,Praticò D</div> <div itemprop="description">MN1020 was used in Immunohistochemistry and Western Blotting to demonstrate that vacuolar protein sorting 35 genetic manipulation modulates the phenotype of mouse models of Alzheimer's disease.</div> <div itemprodp="datePublished">Wed Jan 22 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32398649"> <div itemprop="name">N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Lee JY,Han SH,Park MH,Song IS,Choi MK,Yu E,Park CM,Kim HJ,Kim SH,Schuchman EH,Jin HK,Bae JS</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to identify a role of N-AS in the dysfunction of microglia in AD.</div> <div itemprodp="datePublished">Tue May 12 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32660586"> <div itemprop="name">Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Eckenweber F,Medina-Luque J,Blume T,Sacher C,Biechele G,Wind K,Deussing M,Briel N,Lindner S,Boening G,von Ungern-Sternberg B,Unterrainer M,Albert NL,Zwergal A,Levin J,Bartenstein P,Cumming P,Rominger A,Höglinger GU,Herms J,Brendel M</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to conclude that the contribution of microglial response to pathology accompanying amyloid-β and tau over-expression merits further investigation.</div> <div itemprodp="datePublished">Mon Jul 13 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32832679"> <div itemprop="name">Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer's disease mouse model.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Chen C,Ahn EH,Kang SS,Liu X,Alam A,Ye K</div> <div itemprop="description">MN1020 was used in Western Blotting to support the hypothesis that C/EBPβ/AEP signaling is activated by gut dysbiosis, implicated in AD pathologies in the gut.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32546772"> <div itemprop="name">Alzheimer's disease-related dysregulation of mRNA translation causes key pathological features with ageing.</div> </a> <div itemprop="about">Translational psychiatry</div> <div itemprop="author">Ghosh A,Mizuno K,Tiwari SS,Proitsi P,Gomez Perez-Nievas B,Glennon E,Martinez-Nunez RT,Giese KP</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study the mRNA translation and its underlying signalling and whether they are altered during early AD using a mouse model and studying any pathological features.</div> <div itemprodp="datePublished">Tue Jun 16 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33242767"> <div itemprop="name">Reductive stress promotes protein aggregation and impairs neurogenesis.</div> </a> <div itemprop="about">Redox biology</div> <div itemprop="author">S Narasimhan KK,Devarajan A,Karan G,Sundaram S,Wang Q,van Groen T,Monte FD,Rajasekaran NS</div> <div itemprop="description">MN1020 was used in Immunocytochemistry to show that either acute or chronic RS could hamper neurogenesis through GSK3β/TAU signaling and proteotoxicity.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32093751"> <div itemprop="name">The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Sun Y,Guo Y,Feng X,Jia M,Ai N,Dong Y,Zheng Y,Fu L,Yu B,Zhang H,Wu J,Yu X,Wu H,Kong W</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry (Paraffin) to elucidate the pathogenic mechanisms underlying AD and evaluate therapeutic approaches targeting tau.</div> <div itemprodp="datePublished">Mon Feb 24 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32093751"> <div itemprop="name">The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Sun Y,Guo Y,Feng X,Jia M,Ai N,Dong Y,Zheng Y,Fu L,Yu B,Zhang H,Wu J,Yu X,Wu H,Kong W</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry (Paraffin) to elucidate the pathogenic mechanisms underlying AD and evaluate therapeutic approaches targeting tau.</div> <div itemprodp="datePublished">Mon Feb 24 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32692785"> <div itemprop="name">Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Yadikar H,Torres I,Aiello G,Kurup M,Yang Z,Lin F,Kobeissy F,Yost R,Wang KK</div> <div itemprop="description">MN1020 was used in Western Blotting to provide a comprehensive view of potential drug candidates (TBB, CsA, AR, and Saracatinib), and their efficacy against tau hyperphosphorylation and oligomerization processes.</div> <div itemprodp="datePublished">Fri Sep 04 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33060648"> <div itemprop="name">Explosive-driven double-blast exposure: molecular, histopathological, and behavioral consequences.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Murphy EK,Iacono D,Pan H,Grimes JB,Parks S,Raiciulescu S,Leonessa F,Perl DP</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to identify molecular, histopathological, and behavioral changes in rats 2 weeks after explosive-driven double-blast exposure.</div> <div itemprodp="datePublished">Thu Oct 15 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33060648"> <div itemprop="name">Explosive-driven double-blast exposure: molecular, histopathological, and behavioral consequences.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Murphy EK,Iacono D,Pan H,Grimes JB,Parks S,Raiciulescu S,Leonessa F,Perl DP</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry to identify molecular, histopathological, and behavioral changes in rats 2 weeks after explosive-driven double-blast exposure.</div> <div itemprodp="datePublished">Thu Oct 15 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32611392"> <div itemprop="name">Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Tang SJ,Fesharaki-Zadeh A,Takahashi H,Nies SH,Smith LM,Luo A,Chyung A,Chiasseu M,Strittmatter SM</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to discover whether pharmacological Fyn inhibition alters Tauopathy.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31978364"> <div itemprop="name">Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission.</div> </a> <div itemprop="about">Cell stem cell</div> <div itemprop="author">Zheng J,Li HL,Tian N,Liu F,Wang L,Yin Y,Yue L,Ma L,Wan Y,Wang JZ</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to evidence that intracellular accumulation of tau in GABAergic interneurons impairs AHN by suppressing GABAergic transmission and disinhibiting neural circuits within the neurogenic niche, suggesting a potential of GABAergic potentiators for pro-neurogenic or cell therapies of AD.</div> <div itemprodp="datePublished">Thu Mar 05 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31950334"> <div itemprop="name">Fulminant corticobasal degeneration: a distinct variant with predominant neuronal tau aggregates.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Ling H,Gelpi E,Davey K,Jaunmuktane Z,Mok KY,Jabbari E,Simone R,R'Bibo L,Brandner S,Ellis MJ,Attems J,Mann D,Halliday GM,Al-Sarraj S,Hedreen J,Ironside JW,Kovacs GG,Kovari E,Love S,Vonsattel JPG,Allinson KSJ,Hansen D,Bradshaw T,Setó-Salvia N,Wray S,de Silva R,Morris HR,Warner TT,Hardy J,Holton JL,Revesz T</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate the neuropathological characteristics of corticobasal degeneration.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32630447"> <div itemprop="name">IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated <i>TREM2</i> R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Martins S,Müller-Schiffmann A,Erichsen L,Bohndorf M,Wruck W,Sleegers K,Van Broeckhoven C,Korth C,Adjaye J</div> <div itemprop="description">MN1020 was used in Western Blotting to study the molecular mechanisms underlying the etiology of late-onset Alzheimer´s disease (LOAD).</div> <div itemprodp="datePublished">Thu Jun 25 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32699110"> <div itemprop="name">Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Katsikoudi A,Ficulle E,Cavallini A,Sharman G,Guyot A,Zagnoni M,Eastwood BJ,Hutton M,Bose S</div> <div itemprop="description">MN1020 was used in Western Blotting to show that a small molecule inhibitor of aggregation can block the trans-neuronal transfer of Tau aggregates, suggesting that the system can be used to evaluate mechanisms of Tau transfer and find therapeutic interventions.</div> <div itemprodp="datePublished">Fri Sep 11 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32732936"> <div itemprop="name">Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Dominguez-Meijide A,Vasili E,König A,Cima-Omori MS,Ibáñez de Opakua A,Leonov A,Ryazanov S,Zweckstetter M,Griesinger C,Outeiro TF</div> <div itemprop="description">MN1020 was used in Western Blotting to assess the effects of different pharmacological interventions on the aggregation and internalization of tau and aSyn.</div> <div itemprodp="datePublished">Thu Jul 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33257649"> <div itemprop="name">(D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Chiu CC,Weng YH,Huang YZ,Chen RS,Liu YC,Yeh TH,Lu CS,Lin YW,Chen YJ,Hsu CC,Chiu CH,Wang YT,Chen WS,Liu SY,Wang HL</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry (Frozen) to suggest that PARK17 mutant (D620N) VPS35 impairs activity of Wnt/β-catenin signaling pathway and causes abnormal morphology and dysfunction of mitochondria, which could lead to neurodegeneration of SNpc DAergic cells.</div> <div itemprodp="datePublished">Mon Nov 30 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33257649"> <div itemprop="name">(D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Chiu CC,Weng YH,Huang YZ,Chen RS,Liu YC,Yeh TH,Lu CS,Lin YW,Chen YJ,Hsu CC,Chiu CH,Wang YT,Chen WS,Liu SY,Wang HL</div> <div itemprop="description">MN1020 was used in Western Blot, Immunohistochemistry (Frozen) to suggest that PARK17 mutant (D620N) VPS35 impairs activity of Wnt/β-catenin signaling pathway and causes abnormal morphology and dysfunction of mitochondria, which could lead to neurodegeneration of SNpc DAergic cells.</div> <div itemprodp="datePublished">Mon Nov 30 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33261640"> <div itemprop="name">Altered striatal dopamine levels in Parkinson's disease VPS35 D620N mutant transgenic aged mice.</div> </a> <div itemprop="about">Molecular brain</div> <div itemprop="author">Vanan S,Zeng X,Chia SY,Varnäs K,Jiang M,Zhang K,Saw WT,Padmanabhan P,Yu WP,Zhou ZD,Halldin C,Gulyás B,Tan EK,Zeng L</div> <div itemprop="description">MN1020 was used in Western Blotting to find that VPS35 D620N Tg mice displayed a significantly higher dopamine level than NTg counterparts.</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30510257"> <div itemprop="name">Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.</div> </a> <div itemprop="about">Nature medicine</div> <div itemprop="author">Swarup V,Hinz FI,Rexach JE,Noguchi KI,Toyoshiba H,Oda A,Hirai K,Sarkar A,Seyfried NT,Cheng C,Haggarty SJ,Grossman M,Van Deerlin VM,Trojanowski JQ,Lah JJ,Levey AI,Kondou S,Geschwind DH</div> <div itemprop="description">MN1020 was used in Western Blotting to identify small molecules that can normalize the disease-associated modules.</div> <div itemprodp="datePublished">Tue Jan 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30894745"> <div itemprop="name">Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Falcon B,Zivanov J,Zhang W,Murzin AG,Garringer HJ,Vidal R,Crowther RA,Newell KL,Ghetti B,Goedert M,Scheres SHW</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to provide a unifying neuropathological criterion for CTE, and support the hypothesis that the formation and propagation of distinct conformers of assembled tau underlie different neurodegenerative diseases.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30734106"> <div itemprop="name">Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Perez SE,Miguel JC,He B,Malek-Ahmadi M,Abrahamson EE,Ikonomovic MD,Lott I,Doran E,Alldred MJ,Ginsberg SD,Mufson EJ</div> <div itemprop="description"></div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30734106"> <div itemprop="name">Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Perez SE,Miguel JC,He B,Malek-Ahmadi M,Abrahamson EE,Ikonomovic MD,Lott I,Doran E,Alldred MJ,Ginsberg SD,Mufson EJ</div> <div itemprop="description"></div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30734106"> <div itemprop="name">Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Perez SE,Miguel JC,He B,Malek-Ahmadi M,Abrahamson EE,Ikonomovic MD,Lott I,Doran E,Alldred MJ,Ginsberg SD,Mufson EJ</div> <div itemprop="description"></div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31504240"> <div itemprop="name">CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Mancuso R,Fryatt G,Cleal M,Obst J,Pipi E,Monzón-Sandoval J,Ribe E,Winchester L,Webber C,Nevado A,Jacobs T,Austin N,Theunis C,Grauwen K,Daniela Ruiz E,Mudher A,Vicente-Rodriguez M,Parker CA,Simmons C,Cash D,Richardson J,Jones DNC,Lovestone S,Gómez-Nicola D,Perry VH</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to tested the efficacy of the selective CSF1R inhibitor JNJ-40346527 in the P301S mouse tauopathy model.</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31504240"> <div itemprop="name">CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Mancuso R,Fryatt G,Cleal M,Obst J,Pipi E,Monzón-Sandoval J,Ribe E,Winchester L,Webber C,Nevado A,Jacobs T,Austin N,Theunis C,Grauwen K,Daniela Ruiz E,Mudher A,Vicente-Rodriguez M,Parker CA,Simmons C,Cash D,Richardson J,Jones DNC,Lovestone S,Gómez-Nicola D,Perry VH</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to tested the efficacy of the selective CSF1R inhibitor JNJ-40346527 in the P301S mouse tauopathy model.</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30847469"> <div itemprop="name">In vivo imaging reveals reduced activity of neuronal circuits in a mouse tauopathy model.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Marinković P,Blumenstock S,Goltstein PM,Korzhova V,Peters F,Knebl A,Herms J</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate the effects of various pathological tau species on neuronal network functioning.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31268600"> <div itemprop="name">Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">Evans HT,Benetatos J,van Roijen M,Bodea LG,Götz J</div> <div itemprop="description">MN1020 was used in Immunohistochemistry - Free Floating to present a potential pathomechanism by which pathological tau interferes with cellular functions through the dysregulation of ribosomal protein synthesis.</div> <div itemprodp="datePublished">Mon Jul 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30283031"> <div itemprop="name">Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.</div> </a> <div itemprop="about">Molecular psychiatry</div> <div itemprop="author">Audrain M,Haure-Mirande JV,Wang M,Kim SH,Fanutza T,Chakrabarty P,Fraser P,St George-Hyslop PH,Golde TE,Blitzer RD,Schadt EE,Zhang B,Ehrlich ME,Gandy S</div> <div itemprop="description">MN1020 was used in Western Blotting to characterise in mice the effects of TYROBP deficiency on the phenotypic and pathological evolution of tauopathy.</div> <div itemprodp="datePublished">Sun Sep 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30700593"> <div itemprop="name">TDP43 pathology in the brain, spinal cord, and dorsal root ganglia of a patient with FOSMN.</div> </a> <div itemprop="about">Neurology</div> <div itemprop="author">Rossor AM,Jaunmuktane Z,Rossor MN,Hoti G,Reilly MM</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to describe the histopathologic features of a case of facial-onset sensory and motor neuronopathy.</div> <div itemprodp="datePublished">Tue Feb 26 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31376172"> <div itemprop="name">Amylin as a potential link between type 2 diabetes and alzheimer disease.</div> </a> <div itemprop="about">Annals of neurology</div> <div itemprop="author">Martinez-Valbuena I,Valenti-Azcarate R,Amat-Villegas I,Riverol M,Marcilla I,de Andrea CE,Sánchez-Arias JA,Del Mar Carmona-Abellan M,Marti G,Erro ME,Martínez-Vila E,Tuñon MT,Luquin MR</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to assess ed whether tau and β-amyloid (Aβ) deposits might be present in pancreatic tissue of subjects with Alzheimer's disease, and whether amylin, an amyloidogenic protein deposited in the pancreas of T2DM patients, might accumulate in the brain of Alzheimer's disease patients.</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30488653"> <div itemprop="name">Temporal and regional progression of Alzheimer's disease-like pathology in 3xTg-AD mice.</div> </a> <div itemprop="about">Aging cell</div> <div itemprop="author">Belfiore R,Rodin A,Ferreira E,Velazquez R,Branca C,Caccamo A,Oddo S</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to indicate a consistent and predictable progression of the AD-like pathology in female 3xTg-AD mice, and will facilitate the design of future studies using these mice.</div> <div itemprodp="datePublished">Fri Feb 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31560166"> <div itemprop="name">Early-life exposure to high-fat diet influences brain health in aging mice.</div> </a> <div itemprop="about">Aging cell</div> <div itemprop="author">Di Meco A,Praticò D</div> <div itemprop="description">MN1020 was used in Western Blotting to investigate the effect that maternal high-fat diet during gestation has on brain health of the offspring later in life.</div> <div itemprodp="datePublished">Sun Dec 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31560166"> <div itemprop="name">Early-life exposure to high-fat diet influences brain health in aging mice.</div> </a> <div itemprop="about">Aging cell</div> <div itemprop="author">Di Meco A,Praticò D</div> <div itemprop="description">MN1020 was used in Western Blotting to investigate the effect that maternal high-fat diet during gestation has on brain health of the offspring later in life.</div> <div itemprodp="datePublished">Sun Dec 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31165579"> <div itemprop="name">Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies.</div> </a> <div itemprop="about">Aging cell</div> <div itemprop="author">Zhang J,Chen B,Lu J,Wu Y,Wang S,Yao Z,Zhu L,Qiao Y,Sun Q,Qin W,Zhao Q,Jia J,Wei C</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to indicate that the cerebral amyloid beta dimer plats an important role in Alzheimer's disease pathogenesis, so targeting this dimer is a promising strategy for preventing this disease.</div> <div itemprodp="datePublished">Thu Aug 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31165579"> <div itemprop="name">Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies.</div> </a> <div itemprop="about">Aging cell</div> <div itemprop="author">Zhang J,Chen B,Lu J,Wu Y,Wang S,Yao Z,Zhu L,Qiao Y,Sun Q,Qin W,Zhao Q,Jia J,Wei C</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to indicate that the cerebral amyloid beta dimer plats an important role in Alzheimer's disease pathogenesis, so targeting this dimer is a promising strategy for preventing this disease.</div> <div itemprodp="datePublished">Thu Aug 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31264169"> <div itemprop="name">Discovery and preclinical characterization of [<sup>18</sup>F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies.</div> </a> <div itemprop="about">European journal of nuclear medicine and molecular imaging</div> <div itemprop="author">Kroth H,Oden F,Molette J,Schieferstein H,Capotosti F,Mueller A,Berndt M,Schmitt-Willich H,Darmency V,Gabellieri E,Boudou C,Juergens T,Varisco Y,Vokali E,Hickman DT,Tamagnan G,Pfeifer A,Dinkelborg L,Muhs A,Stephens A</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to characterise the novel compound [18F]PI-2620 and use it to assess the pathology of tau in Alzheimer's disease.</div> <div itemprodp="datePublished">Sun Sep 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30196792"> <div itemprop="name">A protocol for precise comparisons of small vessel disease lesions between ex vivo magnetic resonance imaging and histopathology.</div> </a> <div itemprop="about">International journal of stroke : official journal of the International Stroke Society</div> <div itemprop="author">Humphreys CA,Jansen MA,Muñoz Maniega S,González-Castro V,Pernet C,Deary IJ,Al-Shahi Salman R,Wardlaw JM,Smith C</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to identify and define the cellular characteristics of small vessel disease lesions in human post-mortem brain tissue, in relation to the lesions seen on neuroimaging.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31061088"> <div itemprop="name">Limiting Neuronal Nogo Receptor 1 Signaling during Experimental Autoimmune Encephalomyelitis Preserves Axonal Transport and Abrogates Inflammatory Demyelination.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Lee JY,Kim MJ,Thomas S,Oorschot V,Ramm G,Aui PM,Sekine Y,Deliyanti D,Wilkinson-Berka J,Niego B,Harvey AR,Theotokis P,McLean C,Strittmatter SM,Petratos S</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to identify that abrogating the NgR1/pCRMP2 signaling cascade can maintain Kinesin-1-dependent anterograde axonal transport to limit inflammatory-mediated axonopathy and demyelination.</div> <div itemprodp="datePublished">Wed Jul 10 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31527120"> <div itemprop="name">Depletion of Caveolin-1 in Type 2 Diabetes Model Induces Alzheimer's Disease Pathology Precursors.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Bonds JA,Shetti A,Bheri A,Chen Z,Disouky A,Tai L,Mao M,Head BP,Bonini MG,Haus JM,Minshall RD,Lazarov O</div> <div itemprop="description">MN1020 was used in Western Blotting to show that the expression of caveolin-1 (Cav-1) is reduced in the brain in Type 2 diabetes mellitus.</div> <div itemprodp="datePublished">Wed Oct 23 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30853886"> <div itemprop="name">Amyloid β Induces Early Changes in the Ribosomal Machinery, Cytoskeletal Organization and Oxidative Phosphorylation in Retinal Photoreceptor Cells.</div> </a> <div itemprop="about">Frontiers in molecular neuroscience</div> <div itemprop="author">Deng L,Pushpitha K,Joseph C,Gupta V,Rajput R,Chitranshi N,Dheer Y,Amirkhani A,Kamath K,Pascovici D,Wu JX,Salekdeh GH,Haynes PA,Graham SL,Gupta VK,Mirzaei M</div> <div itemprop="description">MN1020 was used in Western Blot to investigate the proteins and biochemical networks that are affected by amyloid Β in the 661 W photoreceptor cells in culture.</div> <div itemprodp="datePublished">Fri Oct 06 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30890929"> <div itemprop="name">Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau <i>in vivo</i>.</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Miao J,Shi R,Li L,Chen F,Zhou Y,Tung YC,Hu W,Gong CX,Iqbal K,Liu F</div> <div itemprop="description">MN1020 was used in Western Blotting to speculate that AD P-tau seeds hyperphosphorylated tau to form aggregates, which resist to the dephosphorylation by PP2A, resulting in hyperphosphorylation and pathology of tau.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31572168"> <div itemprop="name"><i>In vivo</i> Bioluminescence Imaging Used to Monitor Disease Activity and Therapeutic Response in a Mouse Model of Tauopathy.</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Dunn-Meynell AA,Dowling P,Marchese M,Rodriguez E,Blumberg B,Choi YB,Gaindh D,Lu W</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to use serial bioluminescent images to define the onset and the time course of astrogliosis in mice.</div> <div itemprodp="datePublished">Sat Oct 14 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30783964"> <div itemprop="name">Correlations Between Single Nucleotide Polymorphisms, Cognitive Dysfunction, and Postmortem Brain Pathology in Alzheimer's Disease Among Han Chinese.</div> </a> <div itemprop="about">Neuroscience bulletin</div> <div itemprop="author">Yang Q,Chen K,Zhang H,Zhang W,Gong C,Zhang Q,Liu P,Sun T,Xu Y,Qian X,Qiu W,Ma C</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to examine the distribution of five Alzheimer's disease (AD)-related single nucleotide polymorphisms (SNPs) in the Han population.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30136628"> <div itemprop="name">Repetitive Concussive and Subconcussive Injury in a Human Tau Mouse Model Results in Chronic Cognitive Dysfunction and Disruption of White Matter Tracts, But Not Tau Pathology.</div> </a> <div itemprop="about">Journal of neurotrauma</div> <div itemprop="author">Gangolli M,Benetatos J,Esparza TJ,Fountain EM,Seneviratne S,Brody DL</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to determine the effect of repetitive brain trauma in adult mice and observe changes in tau tangle accumulation.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31521745"> <div itemprop="name">The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice.</div> </a> <div itemprop="about">Molecular and cellular neurosciences</div> <div itemprop="author">Young ML,Franklin JL</div> <div itemprop="description">MN1020 was used in Immunohistochemistry (Paraffin) to support a role for the involvement of mitochondria-derived oxidative stress in the etiology of AD and suggest that mitochondria-targeted antioxidants may lessen symptoms in AD patients.</div> <div itemprodp="datePublished">Sun Dec 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30193818"> <div itemprop="name">Hypertrophy of nigral neurons in Torsin1A deletion (DYT1) carriers manifesting dystonia.</div> </a> <div itemprop="about">Parkinsonism & related disorders</div> <div itemprop="author">Iacono D,Geraci-Erck M,Peng H,Rabin ML,Kurlan R</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to individuate morphometric changes and prevalent types of intraneuronal inclusions in nigral neurons of DYT1 dystonia autopsy-brains.</div> <div itemprodp="datePublished">Tue Jan 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30507579"> <div itemprop="name">Increased Hyaluronan and TSG-6 in Association with Neuropathologic Changes of Alzheimer's Disease.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Reed MJ,Damodarasamy M,Pathan JL,Chan CK,Spiekerman C,Wight TN,Banks WA,Day AJ,Vernon RB,Keene CD</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to indicate a positive correlation between HA accumulation and AD neuropathology, and suggest a possible role for HA synthesis and metabolism in AD progression.</div> <div itemprodp="datePublished">Mon Mar 02 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30958368"> <div itemprop="name">Phospho-Tau Changes in the Human CA1 During Alzheimer's Disease Progression.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Regalado-Reyes M,Furcila D,Hernández F,Ávila J,DeFelipe J,León-Espinosa G</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study the molecular and structural changes responsible for neurofibrillary tangle development.</div> <div itemprodp="datePublished">Wed Sep 09 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31275224"> <div itemprop="name">Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling.</div> </a> <div itemprop="about">Frontiers in neurology</div> <div itemprop="author">Wan W,Cao L,Kalionis B,Murthi P,Xia S,Guan Y</div> <div itemprop="description">MN1020 was used in Western Blot to observe that ferrous (Fe2+) chloride led to aberrant phosphorylation of tau, and decreased tyrosine phosphorylation levels of insulin receptor β (IRβ), insulin signal substrate 1 (IRS-1) and phosphoinositide 3-kinase p85α (PI3K p85α), in primary cultured neurons.</div> <div itemprodp="datePublished">Wed Sep 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31787925"> <div itemprop="name">BDNF Val66Met Genetic Polymorphism Results in Poor Recovery Following Repeated Mild Traumatic Brain Injury in a Mouse Model and Treatment With AAV-BDNF Improves Outcomes.</div> </a> <div itemprop="about">Frontiers in neurology</div> <div itemprop="author">Giarratana AO,Teng S,Reddi S,Zheng C,Adler D,Thakker-Varia S,Alder J</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate the effect of a single nucleotide polymorphism in Brain-derived neurotrophic factor at amino acid 66 on recovery after traumatic brain injury.</div> <div itemprodp="datePublished">Mon Sep 28 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31144289"> <div itemprop="name">Associations of regional amyloid-β plaque and phospho-tau pathology with biological factors and neuropsychological functioning among HIV-infected adults.</div> </a> <div itemprop="about">Journal of neurovirology</div> <div itemprop="author">Soontornniyomkij V,Moore DJ,Gouaux B,Soontornniyomkij B,Sinsheimer JS,Levine AJ</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to conclude that Aβ plaque or p-tau pathology in different brain regions was predicted by different sets of biological factors.</div> <div itemprodp="datePublished">Sun Dec 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31379517"> <div itemprop="name">Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease.</div> </a> <div itemprop="about">Frontiers in neuroanatomy</div> <div itemprop="author">Bullmann T,Feneberg E,Kretzschmann TP,Ogunlade V,Holzer M,Arendt T</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to conclude that hibernation is associated with a specific olfactory memory deficit, which might not be attributed to the formation of PHF-like phosphorylated tau within the olfactory bulb as seen in Alzheimer's Disease.</div> <div itemprodp="datePublished">Fri Oct 13 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31379517"> <div itemprop="name">Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease.</div> </a> <div itemprop="about">Frontiers in neuroanatomy</div> <div itemprop="author">Bullmann T,Feneberg E,Kretzschmann TP,Ogunlade V,Holzer M,Arendt T</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to conclude that hibernation is associated with a specific olfactory memory deficit, which might not be attributed to the formation of PHF-like phosphorylated tau within the olfactory bulb as seen in Alzheimer's Disease.</div> <div itemprodp="datePublished">Fri Oct 13 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31379517"> <div itemprop="name">Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease.</div> </a> <div itemprop="about">Frontiers in neuroanatomy</div> <div itemprop="author">Bullmann T,Feneberg E,Kretzschmann TP,Ogunlade V,Holzer M,Arendt T</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to conclude that hibernation is associated with a specific olfactory memory deficit, which might not be attributed to the formation of PHF-like phosphorylated tau within the olfactory bulb as seen in Alzheimer's Disease.</div> <div itemprodp="datePublished">Fri Oct 13 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31379517"> <div itemprop="name">Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease.</div> </a> <div itemprop="about">Frontiers in neuroanatomy</div> <div itemprop="author">Bullmann T,Feneberg E,Kretzschmann TP,Ogunlade V,Holzer M,Arendt T</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to conclude that hibernation is associated with a specific olfactory memory deficit, which might not be attributed to the formation of PHF-like phosphorylated tau within the olfactory bulb as seen in Alzheimer's Disease.</div> <div itemprodp="datePublished">Fri Oct 13 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31920568"> <div itemprop="name">Subregional Density of Neurons, Neurofibrillary Tangles and Amyloid Plaques in the Hippocampus of Patients With Alzheimer's Disease.</div> </a> <div itemprop="about">Frontiers in neuroanatomy</div> <div itemprop="author">Furcila D,Domínguez-Álvaro M,DeFelipe J,Alonso-Nanclares L</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to examine the possible relationship of both Aβ plaques and NFTs with neuronal loss in several hippocampal fields (DG, CA3, CA1, and subiculum) of 11 demented AD patients.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30906318"> <div itemprop="name">Memantine Differentially Regulates Tau Phosphorylation Induced by Chronic Restraint Stress of Varying Duration in Mice.</div> </a> <div itemprop="about">Neural plasticity</div> <div itemprop="author">Liu Y,Cao L,Zhang X,Liang Y,Xu Y,Zhu C</div> <div itemprop="description">MN1020 was used in Western Blotting to investigate the effects of memantine, an uncompetitive N-methyl-D-aspartate receptor antagonist, on chronic restraint stress- induced tau phosphorylation in mice.</div> <div itemprodp="datePublished">Mon May 13 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30578640"> <div itemprop="name">Astrocytic changes with aging and Alzheimer's disease-type pathology in chimpanzees.</div> </a> <div itemprop="about">The Journal of comparative neurology</div> <div itemprop="author">Munger EL,Edler MK,Hopkins WD,Ely JJ,Erwin JM,Perl DP,Mufson EJ,Hof PR,Sherwood CC,Raghanti MA</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to examine the relationships among aging, Alzheimer''s disease-type pathology, and astrocyte activation in chimpanzees.</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30422056"> <div itemprop="name">In vitro generation of tau aggregates conformationally distinct from parent tau seeds of Alzheimer's brain.</div> </a> <div itemprop="about">Prion</div> <div itemprop="author">Nam WH,Choi YP</div> <div itemprop="description">MN1020 was used in Immunocytochemistry-immunoflourescence to characterise how in vitro generated tau aggregates are conformationally distinct from parent seeds of Alzheimer's brain.</div> <div itemprodp="datePublished">Tue Jan 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31108976"> <div itemprop="name">Mixed <i>Borrelia burgdorferi</i> and <i>Helicobacter pylori</i> Biofilms in Morgellons Disease Dermatological Specimens.</div> </a> <div itemprop="about">Healthcare (Basel, Switzerland)</div> <div itemprop="author">Middelveen MJ,Filush KR,Bandoski C,Kasliwala RS,Melillo A,Stricker RB,Sapi E</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study the coexistance of of Borriella burgdorferi and Heliobacter pylori in skin specimens from Morgellons disease patients.</div> <div itemprodp="datePublished">Fri May 17 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31572127"> <div itemprop="name">Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade.</div> </a> <div itemprop="about">Frontiers in cellular neuroscience</div> <div itemprop="author">Chiu CC,Yeh TH,Chen RS,Chen HC,Huang YZ,Weng YH,Cheng YC,Liu YC,Cheng AJ,Lu YC,Chen YJ,Lin YW,Hsu CC,Chen YL,Lu CS,Wang HL</div> <div itemprop="description">MN1020 was used in Western Blotting to study the role of microRNA (miR-204-5p) in dopaminergic neurone death in Parkinson's disease.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31481130"> <div itemprop="name">Encephalopathy induced by Alzheimer brain inoculation in a non-human primate.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Gary C,Lam S,Hérard AS,Koch JE,Petit F,Gipchtein P,Sawiak SJ,Caillierez R,Eddarkaoui S,Colin M,Aujard F,Deslys JP,Brouillet E,Buée L,Comoy EE,Pifferi F,Picq JL,Dhenain M</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to demonstrate long term memory and learning impairments in a non-human primate following intracerebral injections with Alzheimer human brain extracts.</div> <div itemprodp="datePublished">Wed Sep 04 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31594233"> <div itemprop="name">Extracellular Vesicles Isolated from Familial Alzheimer's Disease Neuronal Cultures Induce Aberrant Tau Phosphorylation in the Wild-Type Mouse Brain.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Aulston B,Liu Q,Mante M,Florio J,Rissman RA,Yuan SH</div> <div itemprop="description">MN1020 was used in Western Blotting to identify EVs as a potential mediator of fAD-associated tau dysregulation and warrant future studies to investigate the therapeutic potential of EV-targeted treatments for fAD.</div> <div itemprodp="datePublished">Tue Nov 17 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31864418"> <div itemprop="name">Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Mendsaikhan A,Tooyama I,Bellier JP,Serrano GE,Sue LI,Lue LF,Beach TG,Walker DG</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to show the role and interactions of lysosomal proteins Progranulin and Prosaposin in the brains of aged patients and those with Alzheimer's.</div> <div itemprodp="datePublished">Sat Dec 21 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31543505"> <div itemprop="name">A unique tau conformation generated by an acetylation-mimic substitution modulates P301S-dependent tau pathology and hyperphosphorylation.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Ajit D,Trzeciakiewicz H,Tseng JH,Wander CM,Chen Y,Ajit A,King DP,Cohen TJ</div> <div itemprop="description">MN1020 was used in Western Blotting to indicate that a complex tau PTM code likely regulates tau pathogenesis, highlighting the potential utility of manipulating and detoxifying tau strains through site-specific tau-targeting approaches.</div> <div itemprodp="datePublished">Fri Nov 08 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30699343"> <div itemprop="name">REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Meyer K,Feldman HM,Lu T,Drake D,Lim ET,Ling KH,Bishop NA,Pan Y,Seo J,Lin YT,Su SC,Church GM,Tsai LH,Yankner BA</div> <div itemprop="description">MN1020 was used in Western Blotting to propose that dysregulation of neural gene networks may set in motion the pathologic cascade that leads to AD.</div> <div itemprodp="datePublished">Tue Jan 29 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31057061"> <div itemprop="name">Arterial Stiffness Due to Carotid Calcification Disrupts Cerebral Blood Flow Regulation and Leads to Cognitive Deficits.</div> </a> <div itemprop="about">Journal of the American Heart Association</div> <div itemprop="author">Muhire G,Iulita MF,Vallerand D,Youwakim J,Gratuze M,Petry FR,Planel E,Ferland G,Girouard H</div> <div itemprop="description">MN1020 was used in Western Blotting to study the mechanisms by which arterial stiffness can contribute to cerebral dysfucntion.</div> <div itemprodp="datePublished">Tue May 07 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31231552"> <div itemprop="name">Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy.</div> </a> <div itemprop="about">NPJ vaccines</div> <div itemprop="author">Maphis NM,Peabody J,Crossey E,Jiang S,Jamaleddin Ahmad FA,Alvarez M,Mansoor SK,Yaney A,Yang Y,Sillerud LO,Wilson CM,Selwyn R,Brigman JL,Cannon JL,Peabody DS,Chackerian B,Bhaskar K</div> <div itemprop="description">MN1020 was used in Western Blotting to provide a valid scientific premise for the development of VLP-based immunotherapy to target pTau and potentially prevent Alzheimer's diseases and related tauopathies.</div> <div itemprodp="datePublished">Wed Feb 03 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31315045"> <div itemprop="name">Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Wang ZH,Xiang J,Liu X,Yu SP,Manfredsson FP,Sandoval IM,Wu S,Wang JZ,Ye K</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to show that deprivation of BDNF/TrkB increases inflammatory cytokines and activates the JAK2/STAT3 pathway, resulting in the upregulation of transcription factor C/EBPβ in Alzheimer''s Disease.</div> <div itemprodp="datePublished">Tue Jul 16 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31226738"> <div itemprop="name">Preventive Effect of Quercetin in a Triple Transgenic Alzheimer's Disease Mice Model.</div> </a> <div itemprop="about">Molecules (Basel, Switzerland)</div> <div itemprop="author">Paula PC,Angelica Maria SG,Luis CH,Gloria Patricia CG</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study the effect of chronic oral quercetin administration on neurodegeneration markers and cognitive and emotional deficits in Alzheimer's disease.</div> <div itemprodp="datePublished">Thu Jun 20 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31142354"> <div itemprop="name">Alzheimer's disease neuropathological change and loss of matrix/neuropil in patients with idiopathic Normal Pressure Hydrocephalus, a model of Alzheimer's disease.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Libard S,Alafuzoff I</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to assess unique brain tissue samples, obtained from living subjects with idiopathic Normal Pressure Hydrocephalus.</div> <div itemprodp="datePublished">Wed May 29 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31733655"> <div itemprop="name">Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Henderson MX,Sengupta M,Trojanowski JQ,Lee VMY</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to show there is a prevalence of Alzheimer's disease-type tau pathology in leucine-rich repeat kinase 2 familial Parkinson's disease.</div> <div itemprodp="datePublished">Sat Nov 16 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31467276"> <div itemprop="name">Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Jadiya P,Kolmetzky DW,Tomar D,Di Meco A,Lombardi AA,Lambert JP,Luongo TS,Ludtmann MH,Praticò D,Elrod JW</div> <div itemprop="description">MN1020 was used in Western Blotting to provide a link between the calcium dysregulation and metabolic dysfunction hypotheses of Alzheimer's disease (AD) and suggest mCa2+ exchange as potential therapeutic target in AD.</div> <div itemprodp="datePublished">Thu Aug 29 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31332267"> <div itemprop="name">USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Piatnitskaia S,Takahashi M,Kitaura H,Katsuragi Y,Kakihana T,Zhang L,Kakita A,Iwakura Y,Nawa H,Miura T,Ikeuchi T,Hara T,Fujii M</div> <div itemprop="description">MN1020 was used in Immunohistochemistry on paraffin embedded tissues to suggest that USP10 plays a key role in the initiation of pathogenic Tau aggregation in AD through SG formation.</div> <div itemprodp="datePublished">Mon Jul 22 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31332267"> <div itemprop="name">USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Piatnitskaia S,Takahashi M,Kitaura H,Katsuragi Y,Kakihana T,Zhang L,Kakita A,Iwakura Y,Nawa H,Miura T,Ikeuchi T,Hara T,Fujii M</div> <div itemprop="description">MN1020 was used in Immunohistochemistry on paraffin embedded tissues to suggest that USP10 plays a key role in the initiation of pathogenic Tau aggregation in AD through SG formation.</div> <div itemprodp="datePublished">Mon Jul 22 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30650353"> <div itemprop="name">Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Paonessa F,Evans LD,Solanki R,Larrieu D,Wray S,Hardy J,Jackson SP,Livesey FJ</div> <div itemprop="description">MN1020 was used in Immunocytochemistry-immunoflourescence to study the underlying pathogenic mechanisms in inherited frontotemporal dementia.</div> <div itemprodp="datePublished">Tue Jan 15 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31821364"> <div itemprop="name">Developmental expression of human tau in Drosophila melanogaster glial cells induces motor deficits and disrupts maintenance of PNS axonal integrity, without affecting synapse formation.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Scarpelli EM,Trinh VY,Tashnim Z,Krans JL,Keller LC,Colodner KJ</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to determine human tau expression in Drosophila glial cells is deleterious to the maintenance of of glial-axonal interactions in the PNS but does not affect synapse formation.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31306814"> <div itemprop="name">A 4R tauopathy develops without amyloid deposits in aged cat brains.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Poncelet L,Ando K,Vergara C,Mansour S,Suain V,Yilmaz Z,Reygel A,Gilissen E,Brion JP,Leroy K</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that the presence of a tau pathology in aged cat brains that develop independently of amyloid deposits.</div> <div itemprodp="datePublished">Sun Sep 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31306814"> <div itemprop="name">A 4R tauopathy develops without amyloid deposits in aged cat brains.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Poncelet L,Ando K,Vergara C,Mansour S,Suain V,Yilmaz Z,Reygel A,Gilissen E,Brion JP,Leroy K</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that the presence of a tau pathology in aged cat brains that develop independently of amyloid deposits.</div> <div itemprodp="datePublished">Sun Sep 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30846870"> <div itemprop="name">Subacute to chronic Alzheimer-like alterations after controlled cortical impact in human tau transgenic mice.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Zhang Y,Wu F,Iqbal K,Gong CX,Hu W,Liu F</div> <div itemprop="description">MN1020 was used in Western Blotting to characterise Alzheimer-like alterations behaviourally, biochemically and immunohistochemically 6 weeks and 7 months after unilateral mild-to-moderate controlled cortical impact in human tau transgenic mice.</div> <div itemprodp="datePublished">Thu Mar 07 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30874605"> <div itemprop="name">Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Andersson CR,Falsig J,Stavenhagen JB,Christensen S,Kartberg F,Rosenqvist N,Finsen B,Pedersen JT</div> <div itemprop="description">MN1020 was used in Immunocytochemistry to study the role of antibody effector functions in the induction of microglial clearance of tau.</div> <div itemprodp="datePublished">Fri Mar 15 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30819250"> <div itemprop="name">Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Christensen KR,Beach TG,Serrano GE,Kanaan NM</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study the importance of targeting tau deposition in Alzheimer's disease, ideally in the initial phases of its deposition in axons.</div> <div itemprodp="datePublished">Thu Feb 28 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30616676"> <div itemprop="name">Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Harrison IF,Whitaker R,Bertelli PM,O'Callaghan JM,Csincsik L,Bocchetta M,Ma D,Fisher A,Ahmed Z,Murray TK,O'Neill MJ,Rohrer JD,Lythgoe MF,Lengyel I</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to examine tau pathology in the neurosensory retina of the rTg(tauP301L)4510 mouse model of frontotemporal dementia.</div> <div itemprodp="datePublished">Mon Jan 07 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31340569"> <div itemprop="name">Microglial Phenotyping in Neurodegenerative Disease Brains: Identification of Reactive Microglia with an Antibody to Variant of CD105/Endoglin.</div> </a> <div itemprop="about">Cells</div> <div itemprop="author">Walker DG,Lue LF,Beach TG,Tooyama I</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to identify subtypes of activated microglia.</div> <div itemprodp="datePublished">Tue Jul 23 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31862015"> <div itemprop="name">Comparative profiling of the synaptic proteome from Alzheimer's disease patients with focus on the APOE genotype.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Hesse R,Hurtado ML,Jackson RJ,Eaton SL,Herrmann AG,Colom-Cadena M,Tzioras M,King D,Rose J,Tulloch J,McKenzie CA,Smith C,Henstridge CM,Lamont D,Wishart TM,Spires-Jones TL</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to identify over 5500 proteins in human synaptoneurosomes and highlighted disease, brain region and apolipoprotein E epsilon 4-associated changes in multiple molecular pathways.</div> <div itemprodp="datePublished">Fri Dec 20 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30158706"> <div itemprop="name">Structures of filaments from Pick's disease reveal a novel tau protein fold.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Falcon B,Zhang W,Murzin AG,Murshudov G,Garringer HJ,Vidal R,Crowther RA,Ghetti B,Scheres SHW,Goedert M</div> <div itemprop="description">MN1020 was used in Western Blotting to show how tau can adopt distinct folds in the human brain in different diseases, an essential step for understanding the formation and propagation of molecular conformers.</div> <div itemprodp="datePublished">Sat Sep 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30232451"> <div itemprop="name">Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Bussian TJ,Aziz A,Meyer CF,Swenson BL,van Deursen JM,Baker DJ</div> <div itemprop="description">MN1020 was used in Western Blotting to study the role of senescent cells in the aetiology of tau-dependent pathologies.</div> <div itemprodp="datePublished">Mon Oct 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29273772"> <div itemprop="name">Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.</div> </a> <div itemprop="about">Nature neuroscience</div> <div itemprop="author">Apicco DJ,Ash PEA,Maziuk B,LeBlang C,Medalla M,Al Abdullatif A,Ferragud A,Botelho E,Ballance HI,Dhawan U,Boudeau S,Cruz AL,Kashy D,Wong A,Goldberg LR,Yazdani N,Zhang C,Ung CY,Tripodis Y,Kanaan NM,Ikezu T,Cottone P,Leszyk J,Li H,Luebke J,Bryant CD,Wolozin B</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to show that reducing the RNA binding protein T-cell intracellular antigen 1 in vivo protects against tau-mediated neurodegeneration.</div> <div itemprodp="datePublished">Mon Jan 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29950669"> <div itemprop="name">A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease.</div> </a> <div itemprop="about">Nature neuroscience</div> <div itemprop="author">Park J,Wetzel I,Marriott I,Dréau D,D'Avanzo C,Kim DY,Tanzi RE,Cho H</div> <div itemprop="description">MN1020 was used in Immunocytochemistry-immunoflourescence to show that the model will serve to facilitate the development of more precise human brain models for basic mechanistic studies in neural-glial interactions and drug discovery.</div> <div itemprodp="datePublished">Sun Jul 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29950669"> <div itemprop="name">A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease.</div> </a> <div itemprop="about">Nature neuroscience</div> <div itemprop="author">Park J,Wetzel I,Marriott I,Dréau D,D'Avanzo C,Kim DY,Tanzi RE,Cho H</div> <div itemprop="description">MN1020 was used in Immunocytochemistry-immunoflourescence to show that the model will serve to facilitate the development of more precise human brain models for basic mechanistic studies in neural-glial interactions and drug discovery.</div> <div itemprodp="datePublished">Sun Jul 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29861287"> <div itemprop="name">APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.</div> </a> <div itemprop="about">Neuron</div> <div itemprop="author">Lin YT,Seo J,Gao F,Feldman HM,Wen HL,Penney J,Cam HP,Gjoneska E,Raja WK,Cheng J,Rueda R,Kritskiy O,Abdurrob F,Peng Z,Milo B,Yu CJ,Elmsaouri S,Dey D,Ko T,Yankner BA,Tsai LH</div> <div itemprop="description">MN1020 was used in Western Blotting to establish a reference for human cell-type-specific changes associated with the APOE4 variant.</div> <div itemprodp="datePublished">Wed Jun 27 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29241829"> <div itemprop="name">The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology.</div> </a> <div itemprop="about">Alzheimer's & dementia : the journal of the Alzheimer's Association</div> <div itemprop="author">Paspalas CD,Carlyle BC,Leslie S,Preuss TM,Crimins JL,Huttner AJ,van Dyck CH,Rosene DL,Nairn AC,Arnsten AFT</div> <div itemprop="description">MN1020 was used in Immunocytochemistry to study the progression of tau and amyloid cortical pathology in the ageing rhesus macaque.</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29273900"> <div itemprop="name">Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Henstridge CM,Sideris DI,Carroll E,Rotariu S,Salomonsson S,Tzioras M,McKenzie CA,Smith C,von Arnim CAF,Ludolph AC,Lulé D,Leighton D,Warner J,Cleary E,Newton J,Swingler R,Chandran S,Gillingwater TH,Abrahams S,Spires-Jones TL</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to assess the synaptic integrity in the amyotrophic lateral sclerosis brain.</div> <div itemprodp="datePublished">Thu Feb 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29450646"> <div itemprop="name">Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Jaunmuktane Z,Quaegebeur A,Taipa R,Viana-Baptista M,Barbosa R,Koriath C,Sciot R,Mead S,Brandner S</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to suggest that amyloid-Β pathology may be transmissible, as prion disease is, through neurosurgical procedures.</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30123935"> <div itemprop="name">Estimation of amyloid distribution by [<sup>18</sup>F]flutemetamol PET predicts the neuropathological phase of amyloid β-protein deposition.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Thal DR,Beach TG,Zanette M,Lilja J,Heurling K,Chakrabarty A,Ismail A,Farrar G,Buckley C,Smith APL</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to investigate whether it is possible to distinguish the neuropathological amyloid Β-protein-phases with amyloid positron emission tomography imaging.</div> <div itemprodp="datePublished">Mon Oct 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29432159"> <div itemprop="name">NAD<sup>+</sup> supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Hou Y,Lautrup S,Cordonnier S,Wang Y,Croteau DL,Zavala E,Zhang Y,Moritoh K,O'Connell JF,Baptiste BA,Stevnsner TV,Mattson MP,Bohr VA</div> <div itemprop="description">MN1020 was used in Western Blotting to examine the role of compromised cellular bioenergetics and DNA repair in the pathogenesis of Alzheimer's disease.</div> <div itemprodp="datePublished">Tue Feb 20 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29508906"> <div itemprop="name">Pedunculopontine Nucleus Cholinergic Deficiency in Cervical Dystonia.</div> </a> <div itemprop="about">Movement disorders : official journal of the Movement Disorder Society</div> <div itemprop="author">Mente K,Edwards NA,Urbano D,Ray-Chaudhury A,Iacono D,Alho ATDL,Alho EJL,Amaro E,Horovitz SG,Hallett M</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to suggest that pedunculopontine nucleus choline acetyltransferase deficiency represents a functional cholinergic deficit in cervical dystonia.</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29246723"> <div itemprop="name">Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.</div> </a> <div itemprop="about">Neurobiology of disease</div> <div itemprop="author">Schapansky J,Khasnavis S,DeAndrade MP,Nardozzi JD,Falkson SR,Boyd JD,Sanderson JB,Bartels T,Melrose HL,LaVoie MJ</div> <div itemprop="description">MN1020 was used in Western Blotting to study the role of neuronal LRRK2 kinase activity in lysosome function and α-synuclein homeostasis.</div> <div itemprodp="datePublished">Thu Mar 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29133432"> <div itemprop="name">Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Chalermpalanupap T,Schroeder JP,Rorabaugh JM,Liles LC,Lah JJ,Levey AI,Weinshenker D</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to investigate the impact of locus coeruleus degeneration in a mouse model of tauopathy.</div> <div itemprodp="datePublished">Wed Jan 03 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29138281"> <div itemprop="name">A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations <i>In Vivo</i>.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Bardai FH,Wang L,Mutreja Y,Yenjerla M,Gamblin TC,Feany MB</div> <div itemprop="description">MN1020 was used in Western Blotting to determine the mechanism by whichFTDP-17 mutations promote disease in vivo.</div> <div itemprodp="datePublished">Wed Jan 03 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30322903"> <div itemprop="name">Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant Mice.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Zhu Y,Zhan G,Fenik P,Brandes M,Bell P,Francois N,Shulman K,Veasey S</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study whether chronic short sleep influences locus ceruleus neurons tau and the biochemical, neuroanatomical, and/or behavioural progression of tauopathy in male and female P301S mice.</div> <div itemprodp="datePublished">Wed Nov 28 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30322903"> <div itemprop="name">Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant Mice.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Zhu Y,Zhan G,Fenik P,Brandes M,Bell P,Francois N,Shulman K,Veasey S</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study whether chronic short sleep influences locus ceruleus neurons tau and the biochemical, neuroanatomical, and/or behavioural progression of tauopathy in male and female P301S mice.</div> <div itemprodp="datePublished">Wed Nov 28 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30197586"> <div itemprop="name">Human Tau Expression Does Not Induce Mouse Retina Neurodegeneration, Suggesting Differential Toxicity of Tau in Brain vs. Retinal Neurons.</div> </a> <div itemprop="about">Frontiers in molecular neuroscience</div> <div itemprop="author">Rodriguez L,Mdzomba JB,Joly S,Boudreau-Laprise M,Planel E,Pernet V</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to show visual physiology may be positively influenced by human Tau expression in retinal cells.</div> <div itemprodp="datePublished">Mon Sep 28 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30337867"> <div itemprop="name">Bilateral Implantation of Shear Stress Modifier in <i>ApoE</i> Knockout Mouse Induces Cognitive Impairment and Tau Abnormalities.</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Nie S,Tan Y,Zhang Z,Chen G,Xiong J,Hu D,Ye K,Zhang Y,Cao X,Chen L,Zhang Z</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate the mechanism underlying vascular cognitive impairment in an Apolipoprotein E knockout mouse model fed with western style food with implantation of bilateral shear stress modifiers.</div> <div itemprodp="datePublished">Tue Sep 29 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30524268"> <div itemprop="name">A Novel hAPP/htau Mouse Model of Alzheimer's Disease: Inclusion of APP With Tau Exacerbates Behavioral Deficits and Zinc Administration Heightens Tangle Pathology.</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Lippi SLP,Smith ML,Flinn JM</div> <div itemprop="description">MN1020 was used in Western Blotting to characterise the offspring from the cross of the J20 and rTg4510 mouse strains.</div> <div itemprodp="datePublished">Wed Sep 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30400087"> <div itemprop="name">Phytochemicals from Achillea fragrantissima are Modulators of AβPP Metabolism.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Bartolotti N,Disouky A,Kalinski A,Elmann A,Lazarov O</div> <div itemprop="description">MN1020 was used in Western Blotting to examine the effect of two Achillea fragrantissima-derived phytochemicals on learning and memory, amyloid-Β protein precursor metabolism, and tau phosphorylation in an Alzheimer's disease model.</div> <div itemprodp="datePublished">Mon Nov 25 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29226863"> <div itemprop="name">Associations between Use of Specific Analgesics and Concentrations of Amyloid-β 42 or Phospho-Tau in Regions of Human Cerebral Cortex.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Flanagan ME,Larson EB,Walker RL,Keene CD,Postupna N,Cholerton B,Sonnen JA,Dublin S,Crane PK,Montine TJ</div> <div itemprop="description">MN1020 was used in an ELISA assay to show that high levels of non-aspirin nonsteroidal anti-inflammatory drug use in older individuals may promote Amyloid-Β 42 accumulation in cerebral cortex.</div> <div itemprodp="datePublished">Tue Jan 15 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29332037"> <div itemprop="name">Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Arner A,Rockenstein E,Mante M,Florio J,Masliah D,Salehi B,Adame A,Overk C,Masliah E,Rissman RA</div> <div itemprop="description">MN1020 was used in an ELISA assay to demonstrate that this bigenic model closely parallels the pathological course of AD and may serve as a valuable model for testing new pharmacological interventions.</div> <div itemprodp="datePublished">Thu Jan 17 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29914033"> <div itemprop="name">A Study of Amyloid-β and Phosphotau in Plaques and Neurons in the Hippocampus of Alzheimer's Disease Patients.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Furcila D,DeFelipe J,Alonso-Nanclares L</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to study the possible relationship between the presence and distribution of different neurochemical types of amyloid-Β plaques and hyperphosphorylated-Tau immunoreactive neurons.</div> <div itemprodp="datePublished">Mon Jul 15 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29562525"> <div itemprop="name">Rab10 Phosphorylation is a Prominent Pathological Feature in Alzheimer's Disease.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Yan T,Wang L,Gao J,Siedlak SL,Huntley ML,Termsarasab P,Perry G,Chen SG,Wang X</div> <div itemprop="description">MN1020 was used in Immunocytochemistry to indicate that Rab10 phosphorylation could be responsible for aberrations in the vesicle trafficking observed in Alzheimer's disease leading to neurodegeneration.</div> <div itemprodp="datePublished">Mon Aug 26 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30483077"> <div itemprop="name">Effects of a Dehydroevodiamine-Derivative on Synaptic Destabilization and Memory Impairment in the 5xFAD, Alzheimer's Disease Mouse Model.</div> </a> <div itemprop="about">Frontiers in behavioral neuroscience</div> <div itemprop="author">Kang S,Ha S,Park H,Nam E,Suh WH,Suh YH,Chang KA</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate the therapeutic effects of carboxy-dehydroevodiamine-HCl and the underlying mechanism in a transgenic mouse model of Alzheimer's disease.</div> <div itemprodp="datePublished">Wed Sep 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30483077"> <div itemprop="name">Effects of a Dehydroevodiamine-Derivative on Synaptic Destabilization and Memory Impairment in the 5xFAD, Alzheimer's Disease Mouse Model.</div> </a> <div itemprop="about">Frontiers in behavioral neuroscience</div> <div itemprop="author">Kang S,Ha S,Park H,Nam E,Suh WH,Suh YH,Chang KA</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate the therapeutic effects of carboxy-dehydroevodiamine-HCl and the underlying mechanism in a transgenic mouse model of Alzheimer's disease.</div> <div itemprodp="datePublished">Wed Sep 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30348994"> <div itemprop="name">APOE ε2 is associated with increased tau pathology in primary tauopathy.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Zhao N,Liu CC,Van Ingelgom AJ,Linares C,Kurti A,Knight JA,Heckman MG,Diehl NN,Shinohara M,Martens YA,Attrebi ON,Petrucelli L,Fryer JD,Wszolek ZK,Graff-Radford NR,Caselli RJ,Sanchez-Contreras MY,Rademakers R,Murray ME,Koga S,Dickson DW,Ross OA,Bu G</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to evaluate the association of Apolipoprotein E genotype with the presence and severity of tau pathology.</div> <div itemprodp="datePublished">Mon Oct 22 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29717219"> <div itemprop="name">Proteomic differences between focal and diffuse traumatic brain injury in human brain tissue.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Abu Hamdeh S,Shevchenko G,Mi J,Musunuri S,Bergquist J,Marklund N</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to evaluate the early molecular response to severe traumatic brain injury.</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29880901"> <div itemprop="name">Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer's disease in the 3xTg-AD mouse model.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Grimaldi A,Brighi C,Peruzzi G,Ragozzino D,Bonanni V,Limatola C,Ruocco G,Di Angelantonio S</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to investigate novel retinal biomarkers that could anticipate the Alzheimer's disease diagnosis, and help the beginning and the follow-up of possible future treatments.</div> <div itemprodp="datePublished">Thu Jun 07 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30001207"> <div itemprop="name">Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser<sup>422</sup> containing epitope on pathological tau.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">van Ameijde J,Crespo R,Janson R,Juraszek J,Siregar B,Verveen H,Sprengers I,Nahar T,Hoozemans JJ,Steinbacher S,Willems R,Delbroek L,Borgers M,Dockx K,Van Kolen K,Mercken M,Pascual G,Koudstaal W,Apetri A</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to indicate that in addition to being able to inhibit the spreading of pathological tau aggregates, the matured antibody can potentially also interfere with the nucleation of tau which is believed to be the first step of the pathogenic process.</div> <div itemprodp="datePublished">Thu Jul 12 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29912063"> <div itemprop="name">Association of antiretroviral therapy with brain aging changes among HIV-infected adults.</div> </a> <div itemprop="about">AIDS (London, England)</div> <div itemprop="author">Soontornniyomkij V,Umlauf A,Soontornniyomkij B,Gouaux B,Ellis RJ,Levine AJ,Moore DJ,Letendre SL</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to investigate antiretroviral therapy effects on age-related brain changes in persons living with HIV.</div> <div itemprodp="datePublished">Mon Sep 10 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28455903"> <div itemprop="name">The physiological phosphorylation of tau is critically changed in fetal brains of individuals with Down syndrome.</div> </a> <div itemprop="about">Neuropathology and applied neurobiology</div> <div itemprop="author">Milenkovic I,Jarc J,Dassler E,Aronica E,Iyer A,Adle-Biassette H,Scharrer A,Reischer T,Hainfellner JA,Kovacs GG</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest functional tau disturbance in DS brains during development, rather than axonal loss.</div> <div itemprodp="datePublished">Sun Apr 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29570886"> <div itemprop="name">Lysosomal LAMP1 immunoreactivity exists in both diffuse and neuritic amyloid plaques in the human hippocampus.</div> </a> <div itemprop="about">The European journal of neuroscience</div> <div itemprop="author">Hassiotis S,Manavis J,Blumbergs PC,Hattersley KJ,Carosi JM,Kamei M,Sargeant TJ</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that diffuse plaques, as well as neuritic plaques, contain LAMP1 immunoreactivity in the human hippocampus.</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29662056"> <div itemprop="name">Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Lee JY,Han SH,Park MH,Baek B,Song IS,Choi MK,Takuwa Y,Ryu H,Kim SH,He X,Schuchman EH,Bae JS,Jin HK</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to uncover a novel mechanism of SphK1 pathogenesis in Alzheimer's disease, in which impaired specialized proresolving mediators secretion leads to defective microglial phagocytosis.</div> <div itemprodp="datePublished">Mon Apr 16 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29121589"> <div itemprop="name">Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy.</div> </a> <div itemprop="about">Redox biology</div> <div itemprop="author">Cuadrado A,Kügler S,Lastres-Becker I</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate whether dimethyl fumarat, an inducer of the transcription factor NRF2, could mitigate tauopathy in a mouse model.</div> <div itemprodp="datePublished">Sun Apr 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29215728"> <div itemprop="name">Multiple neuronal pathologies are common in young patients with pathologically proven Frontotemporal lobar degeneration.</div> </a> <div itemprop="about">Neuropathology and applied neurobiology</div> <div itemprop="author">Tan RH,Yang Y,Halliday GM</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to examine concomitant pathological neuronal inclusions of TDP-43, hyperphosphorylated tau and α-synuclein protein in the anterior cingulate, hippocampus and entorhinal cortex in young (≤65 years at death) vs. elderly (≥80 years at death) cases with pathologically confirmed FTLD (n = 52) or Alzheimer's disease (AD) (n = 47).</div> <div itemprodp="datePublished">Wed Aug 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30417428"> <div itemprop="name">Microglial activation occurs late during preclinical Alzheimer's disease.</div> </a> <div itemprop="about">Glia</div> <div itemprop="author">Streit WJ,Braak H,Del Tredici K,Leyh J,Lier J,Khoshbouei H,Eisenlöffel C,Müller W,Bechmann I</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that the role of microglia in AD pathogenesis entails primarily the attempted removal of potentially toxic, extracellular material.</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29512079"> <div itemprop="name">Neuropathological Assessment as an Endpoint in Clinical Trial Design.</div> </a> <div itemprop="about">Methods in molecular biology (Clifton, N.J.)</div> <div itemprop="author">Gentleman S,Liu AKL</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to present a simple protocol for pathological assessment of neurodegenerative changes.</div> <div itemprodp="datePublished">Wed Feb 06 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30315256"> <div itemprop="name">Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Brekk OR,Moskites A,Isacson O,Hallett PJ</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to identify early protein-lipid interactions that coincide with loss of lipid homeostasis.</div> <div itemprodp="datePublished">Fri Oct 12 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29416036"> <div itemprop="name">A transcriptomic atlas of aged human microglia.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Olah M,Patrick E,Villani AC,Xu J,White CC,Ryan KJ,Piehowski P,Kapasi A,Nejad P,Cimpean M,Connor S,Yung CJ,Frangieh M,McHenry A,Elyaman W,Petyuk V,Schneider JA,Bennett DA,De Jager PL,Bradshaw EM</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to demonstrate the existence of an ageing-related microglial phenotype in the human brain and its involvement in ageing pathology.</div> <div itemprodp="datePublished">Wed Feb 07 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30068908"> <div itemprop="name">Evidence supporting oxidative stress in a moderately affected area of the brain in Alzheimer's disease.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Youssef P,Chami B,Lim J,Middleton T,Sutherland GT,Witting PK</div> <div itemprop="description">MN1020 was used in Western Blotting to evaluate the expression profiles and activity of endogenous anti-oxidants, oxidative damage and caspase activity in the superior temporal gyrus of Alzheimer's disease patients.</div> <div itemprodp="datePublished">Wed Aug 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29945658"> <div itemprop="name">iPSC-derived familial Alzheimer's PSEN2 <sup>N141I</sup> cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling.</div> </a> <div itemprop="about">Molecular neurodegeneration</div> <div itemprop="author">Moreno CL,Della Guardia L,Shnyder V,Ortiz-Virumbrales M,Kruglikov I,Zhang B,Schadt EE,Tanzi RE,Noggle S,Buettner C,Gandy S</div> <div itemprop="description">MN1020 was used in Western Blotting to investigate whether neuronal insulin resistance is a cell autonomous phenomenon in a familial form of Alzheimer's disease.</div> <div itemprodp="datePublished">Tue Jun 26 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29196605"> <div itemprop="name">Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Tuerde D,Kimura T,Miyasaka T,Furusawa K,Shimozawa A,Hasegawa M,Ando K,Hisanaga SI</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study how the transition of the microtubule-associated protein tau isoforms and phosphorylation are regulated.</div> <div itemprodp="datePublished">Fri Feb 02 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30497516"> <div itemprop="name">Different tau species lead to heterogeneous tau pathology propagation and misfolding.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Dujardin S,Bégard S,Caillierez R,Lachaud C,Carrier S,Lieger S,Gonzalez JA,Deramecourt V,Déglon N,Maurage CA,Frosch MP,Hyman BT,Colin M,Buée L</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to show that the existence of specific folding properties of tau depending on isoforms or mutations impacting the behavior of pathological tau species.</div> <div itemprodp="datePublished">Thu Nov 29 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30487735"> <div itemprop="name">Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology.</div> </a> <div itemprop="about">Frontiers in cellular neuroscience</div> <div itemprop="author">Romero-Molina C,Navarro V,Sanchez-Varo R,Jimenez S,Fernandez-Valenzuela JJ,Sanchez-Mico MV,Muñoz-Castro C,Gutierrez A,Vitorica J,Vizuete M</div> <div itemprop="description">MN1020 was used in Western Blotting to compare the microglial response in two different transgenic tau mouse models: ThyTau22 and P301S.</div> <div itemprodp="datePublished">Wed Sep 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29540691"> <div itemprop="name">Next generation histology methods for three-dimensional imaging of fresh and archival human brain tissues.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Lai HM,Liu AKL,Ng HHM,Goldfinger MH,Chau TW,DeFelice J,Tilley BS,Wong WM,Wu W,Gentleman SM</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to develop a tissue clearing solution, OPTIClear, optimised for fresh and archival human brain tissue, including formalin-fixed paraffin-embedded material.</div> <div itemprodp="datePublished">Wed Mar 14 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29499755"> <div itemprop="name">Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer's disease patients.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Domínguez-Álvaro M,Montero-Crespo M,Blazquez-Llorca L,Insausti R,DeFelipe J,Alonso-Nanclares L</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to perform a detailed three-dimensional ultrastructural analysis to investigate possible synaptic alterations in the transentorhinal cortex of patients with Alzheimer's disease.</div> <div itemprodp="datePublished">Fri Mar 02 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29471842"> <div itemprop="name">Toxoplasma gondii alters NMDAR signaling and induces signs of Alzheimer's disease in wild-type, C57BL/6 mice.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Torres L,Robinson SA,Kim DG,Yan A,Cleland TA,Bynoe MS</div> <div itemprop="description">MN1020 was used in Immunohistochemistry on frozen tissues to study the induction of advanced signs of Alzheimer's disease in wild type mice following Toxoplasma gondii infection.</div> <div itemprodp="datePublished">Fri Feb 23 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29958544"> <div itemprop="name">Phosphorylation of different tau sites during progression of Alzheimer's disease.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Neddens J,Temmel M,Flunkert S,Kerschbaumer B,Hoeller C,Loeffler T,Niederkofler V,Daum G,Attems J,Hutter-Paier B</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate total tau and phosphorylated tau as well as amyloid-Β plaques in human brain tissue of Alzheimer's disease patients and controls.</div> <div itemprodp="datePublished">Fri Jun 29 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29776428"> <div itemprop="name">Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Huang C,Irwin MG,Wong GTC,Chang RCC</div> <div itemprop="description">MN1020 was used in Western Blotting to characterise the neuroinflammation and cellular changes induced by systemic inflammation, and their responses to anti-inflammatory treatment.</div> <div itemprodp="datePublished">Thu May 17 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29350601"> <div itemprop="name">Brain tissue Aβ42 levels are linked to shunt response in idiopathic normal pressure hydrocephalus.</div> </a> <div itemprop="about">Journal of neurosurgery</div> <div itemprop="author">Abu Hamdeh S,Virhammar J,Sehlin D,Alafuzoff I,Cesarini KG,Marklund N</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to test if the cortical brain tissue levels of soluble amyloid beta (Aβ) reflect the propensity of cortical Aβ aggregate formation and may be an additional factor predicting surgical outcome following idiopathic normal pressure hydrocephalus (iNPH) treatment.</div> <div itemprodp="datePublished">Fri Jan 19 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27633985"> <div itemprop="name">Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration.</div> </a> <div itemprop="about">Brain, behavior, and immunity</div> <div itemprop="author">Hennessy E,Gormley S,Lopez-Rodriguez AB,Murray C,Murray C,Cunningham C</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to indicate that acutely elevated TNF-α has robust acute effects on brain function, selectively in the degenerating brain.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28111080"> <div itemprop="name">Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.</div> </a> <div itemprop="about">Neuron</div> <div itemprop="author">Fu H,Rodriguez GA,Herman M,Emrani S,Nahmani E,Barrett G,Figueroa HY,Goldberg E,Hussaini SA,Duff KE</div> <div itemprop="description">MN1020 was used in immunohistochemistry - free floating to report the formation of mature tangles in Alzheimer's diseases is associated with excitatory cell loss and deficits in grid cell function</div> <div itemprodp="datePublished">Wed Feb 08 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28238547"> <div itemprop="name">Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.</div> </a> <div itemprop="about">Neuron</div> <div itemprop="author">Espuny-Camacho I,Arranz AM,Fiers M,Snellinx A,Ando K,Munck S,Bonnefont J,Lambot L,Corthout N,Omodho L,Vanden Eynden E,Radaelli E,Tesseur I,Wray S,Ebneth A,Hardy J,Leroy K,Brion JP,Vanderhaeghen P,De Strooper B</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to develop a novel chimeric model for Alzheimer's disease, displaying human-specific pathological features and allowing the analysis of different genetic backgrounds and mutations during the course of disease.</div> <div itemprodp="datePublished">Wed Mar 08 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28238547"> <div itemprop="name">Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.</div> </a> <div itemprop="about">Neuron</div> <div itemprop="author">Espuny-Camacho I,Arranz AM,Fiers M,Snellinx A,Ando K,Munck S,Bonnefont J,Lambot L,Corthout N,Omodho L,Vanden Eynden E,Radaelli E,Tesseur I,Wray S,Ebneth A,Hardy J,Leroy K,Brion JP,Vanderhaeghen P,De Strooper B</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to develop a novel chimeric model for Alzheimer's disease, displaying human-specific pathological features and allowing the analysis of different genetic backgrounds and mutations during the course of disease.</div> <div itemprodp="datePublished">Wed Mar 08 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27885490"> <div itemprop="name">Localized cortical chronic traumatic encephalopathy pathology after single, severe axonal injury in human brain.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Shively SB,Edgerton SL,Iacono D,Purohit DP,Qu BX,Haroutunian V,Davis KL,Diaz-Arrastia R,Perl DP</div> <div itemprop="description">MN1020 was used in western blot to examine postmortem brain tissues from five institutionalized patients with schizophrenia and history of surgical leucotomy with subsequent survival of at least another 40 years</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28064358"> <div itemprop="name">Incipient progressive supranuclear palsy is more common than expected and may comprise clinicopathological subtypes: a forensic autopsy series.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Yoshida K,Hata Y,Kinoshita K,Takashima S,Tanaka K,Nishida N</div> <div itemprop="description">MN1020 was used in immunohistochemistry to analyze autopsied corpses and reveal that progressive supranuclear palsy may be more common than previously thought</div> <div itemprodp="datePublished">Mon May 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28070672"> <div itemprop="name">Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Takahashi H,Klein ZA,Bhagat SM,Kaufman AC,Kostylev MA,Ikezu T,Strittmatter SM</div> <div itemprop="description">MN1020 was used in immunohistochemistry to see that the granulin Alzheimer's disease risk variant has no significant effects on florbetapir positron emission tomographic amyloid imaging and cerebrospinal fluid Abeta levels</div> <div itemprodp="datePublished">Mon May 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27757524"> <div itemprop="name">Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal α-motoneurons in sporadic amyotrophic lateral sclerosis.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Braak H,Ludolph AC,Neumann M,Ravits J,Del Tredici K</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-floating tissue to discuss some implications of this phenomenon of nuclear clearing in the absence of cytoplasmic inclusions, namely, abnormal but soluble cytoplasmic TDP-43 could enter the axoplasm of Betz cells.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28205009"> <div itemprop="name">Mixed pathologies including chronic traumatic encephalopathy account for dementia in retired association football (soccer) players.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Ling H,Morris HR,Neal JW,Lees AJ,Hardy J,Holton JL,Revesz T,Williams DD</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to describe the clinical and pathological features of a group of retired professional footballers who developed dementia in later life.</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29069396"> <div itemprop="name">Presence of tau pathology within foetal neural allografts in patients with Huntington's and Parkinson's disease.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Cisbani G,Maxan A,Kordower JH,Planel E,Freeman TB,Cicchetti F</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study whether tau pathology can be seen in patients with Huntington's and Parkinson's disease who had received foetal neural allografts.</div> <div itemprodp="datePublished">Wed Nov 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28969319"> <div itemprop="name">Effects of propofol and surgery on neuropathology and cognition in the 3xTgAD Alzheimer transgenic mouse model.</div> </a> <div itemprop="about">British journal of anaesthesia</div> <div itemprop="author">Mardini F,Tang JX,Li JC,Arroliga MJ,Eckenhoff RG,Eckenhoff MF</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study the cognitive and neuroinflammatory sequelae induced by surgery under propofol anaesthesia in a vulnerable mouse transgenic model.</div> <div itemprodp="datePublished">Fri Sep 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28160413"> <div itemprop="name">Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model.</div> </a> <div itemprop="about">Aging cell</div> <div itemprop="author">Bodea LG,Evans HT,Van der Jeugd A,Ittner LM,Delerue F,Kril J,Halliday G,Hodges J,Kiernan MC,Götz J</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section and western blot to generate and characterize a new mouse model of Alzheimer's disease</div> <div itemprodp="datePublished">Sat Apr 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28213441"> <div itemprop="name">Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Ogino H,Hisanaga A,Kohno T,Kondo Y,Okumura K,Kamei T,Sato T,Asahara H,Tsuiji H,Fukata M,Hattori M</div> <div itemprop="description">MN1020 was used in Western Blotting to identify the secreted metallomatrix proteinase, ADAMTS-3, as the protein responsible for the cleavage of Reelin in the cerebral cortex and hippocampus.</div> <div itemprodp="datePublished">Wed Mar 22 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28713242"> <div itemprop="name">The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells.</div> </a> <div itemprop="about">Frontiers in molecular neuroscience</div> <div itemprop="author">Di Primio C,Quercioli V,Siano G,Rovere M,Kovacech B,Novak M,Cattaneo A</div> <div itemprop="description">MN1020 was used in Western Blotting to find that soluble Tau molecules, detached from MTs, display an unfolded structure.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28212814"> <div itemprop="name">Human Striatal Dopaminergic and Regional Serotonergic Synaptic Degeneration with Lewy Body Disease and Inheritance of APOE ε4.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Postupna N,Latimer CS,Larson EB,Sherfield E,Paladin J,Shively CA,Jorgensen MJ,Andrews RN,Kaplan JR,Crane PK,Montine KS,Craft S,Keene CD,Montine TJ</div> <div itemprop="description">MN1020 was used in Flow cytometry/Cell sorting to characterise the molecular composition of human synaptic particles in the striatum and prefrontal cortex.</div> <div itemprodp="datePublished">Sat Apr 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28408124"> <div itemprop="name">Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Nobuhara CK,DeVos SL,Commins C,Wegmann S,Moore BD,Roe AD,Costantino I,Frosch MP,Pitstick R,Carlson GA,Hock C,Nitsch RM,Montrasio F,Grimm J,Cheung AE,Dunah AW,Wittmann M,Bussiere T,Weinreb PH,Hyman BT,Takeda S</div> <div itemprop="description">MN1020 was used in an ELISA assay to discover that not all antibodies/epitopes are equally robust in terms of blocking tau uptake of human AD-derived tau species.</div> <div itemprodp="datePublished">Thu Jun 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29379433"> <div itemprop="name">Ventricular and Periventricular Anomalies in the Aging and Cognitively Impaired Brain.</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Todd KL,Brighton T,Norton ES,Schick S,Elkins W,Pletnikova O,Fortinsky RH,Troncoso JC,Molfese PJ,Resnick SM,Conover JC</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to explore the interplay between various ventricular and periventricular anomalies in the ageing and cognitively impaired brain.</div> <div itemprodp="datePublished">Wed Sep 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29311903"> <div itemprop="name">Negative Impact of Female Sex on Outcomes from Repetitive Mild Traumatic Brain Injury in hTau Mice Is Age Dependent: A Chronic Effects of Neurotrauma Consortium Study.</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Ferguson SA,Mouzon BC,Lynch C,Lungmus C,Morin A,Crynen G,Carper B,Bieler G,Mufson EJ,Stewart W,Mullan M,Crawford F</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to elucidate the neurobehavioural and neuropathological effects of repetitive mild traumatic brain injury in mice transgenic for human tau.</div> <div itemprodp="datePublished">Wed Sep 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27000837"> <div itemprop="name">Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation.</div> </a> <div itemprop="about">Molecular neurobiology</div> <div itemprop="author">Chanu SI,Sarkar S</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section and western blot to study suppression of pathogenesis of human neuronal tauopathies in drosophila by limiting tau hyperphosphorylation and heterochromatin relaxation by targeted downregulation of</div> <div itemprodp="datePublished">Mon May 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28004107"> <div itemprop="name">Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model.</div> </a> <div itemprop="about">International journal of molecular medicine</div> <div itemprop="author">Park TS,Ryu YK,Park HY,Kim JY,Go J,Noh JR,Kim YH,Hwang JH,Choi DH,Oh WK,Lee CH,Kim KS</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate whether Humulus japonicus has a beneficial effect on the progression of Alzheimer's disease in APP/PS1 transgenic mice.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28363773"> <div itemprop="name">Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease.</div> </a> <div itemprop="about">Neuropharmacology</div> <div itemprop="author">Zhu H,Xue X,Wang E,Wallack M,Na H,Hooker JM,Kowall N,Tao Q,Stein TD,Wolozin B,Qiu WQ</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study the effect of amylin on the the Alheimer's disease pathological cascade.</div> <div itemprodp="datePublished">Thu Jun 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28319837"> <div itemprop="name">Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic mice.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Krivinko JM,Erickson SL,Abrahamson EE,Wills ZP,Ikonomovic MD,Penzes P,Sweet RA</div> <div itemprop="description">MN1020 was used in Western Blotting to determine the molecular and behavioural consequences of kalirin reduction in APPswe/PSEN1dE9 mice.</div> <div itemprodp="datePublished">Thu Jun 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29059309"> <div itemprop="name">Elevated Intraocular Pressure Induces Amyloid-β Deposition and Tauopathy in the Lateral Geniculate Nucleus in a Monkey Model of Glaucoma.</div> </a> <div itemprop="about">Investigative ophthalmology & visual science</div> <div itemprop="author">Yan Z,Liao H,Chen H,Deng S,Jia Y,Deng C,Lin J,Ge J,Zhuo Y</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to establish the existence of hallmark Alzheimer's disease-like pathologies in the glaucomatous lateral geniculate nucleus.</div> <div itemprodp="datePublished">Sun Oct 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28008748"> <div itemprop="name">TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.</div> </a> <div itemprop="about">Human mutation</div> <div itemprop="author">van der Zee J,Gijselinck I,Van Mossevelde S,Perrone F,Dillen L,Heeman B,Bäumer V,Engelborghs S,De Bleecker J,Baets J,Gelpi E,Rojas-García R,Clarimón J,Lleó A,Diehl-Schmid J,Alexopoulos P,Perneczky R,Synofzik M,Just J,Schöls L,Graff C,Thonberg H,Borroni B,Padovani A,Jordanova A,Sarafov S,Tournev I,de Mendonça A,Miltenberger-Miltényi G,Simões do Couto F,Ramirez A,Jessen F,Heneka MT,Gómez-Tortosa E,Danek A,Cras P,Vandenberghe R,De Jonghe P,De Deyn PP,Sleegers K,Cruts M,Van Broeckhoven C,Goeman J,Nuytten D,Smets K,Robberecht W,Damme PV,Bleecker J,Santens P,Dermaut B,Versijpt J,Michotte A,Ivanoiu A,Deryck O,Bergmans B,Delbeck J,Bruyland M,Willems C,Salmon E,Pastor P,Ortega-Cubero S,Benussi L,Ghidoni R,Binetti G,Hernández I,Boada M,Ruiz A,Sorbi S,Nacmias B,Bagnoli S,Sorbi S,Sanchez-Valle R,Llado A,Santana I,Rosário Almeida M,Frisoni GB,Maetzler W,Matej R,Fraidakis MJ,Kovacs GG,Fabrizi GM,Testi S</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to examine the mutation spectrum of the TANK-Binding Kinase 1 gene and its associated phenotypic spectrum in patients with FTD, ALS or FTD plus ALS</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28582864"> <div itemprop="name">Transactive DNA Binding Protein 43 Rather Than Other Misfolded Proteins in the Brain is Associated with Islet Amyloid Polypeptide in Pancreas in Aged Subjects with Diabetes Mellitus.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Leino M,Popova SN,Alafuzoff I</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to assess ageing-related neurodegenerative lesions associated with dementia such as hyperphosphorylated τ, Aβ, α-synuclein, and phosphorylated transactive DNA binding protein 43 seen in the brain and IAPP seen in the pancreas in subjects with and without diabetes mellitus.</div> <div itemprodp="datePublished">Fri Apr 06 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28490024"> <div itemprop="name">A Novel Ataxic Mutant Mouse Line Having Sensory Neuropathy Shows Heavy Iron Deposition in Kidney.</div> </a> <div itemprop="about">Neuro-degenerative diseases</div> <div itemprop="author">Hashimoto H,Kawabe T,Fukuda T,Kusakabe M</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to suggest that the hak mouse has a tissue-specific impairment in the expression of a type of Bdnf transcripts.</div> <div itemprodp="datePublished">Wed Apr 25 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28792154"> <div itemprop="name">Proposal Guidelines for Standardized Operating Procedures of Brain Autopsy: Brain Bank in South Korea.</div> </a> <div itemprop="about">Yonsei medical journal</div> <div itemprop="author">Lee KH,Seo SW,Lim TS,Kim EJ,Kim BC,Kim Y,Lee HW,Jeon JP,Shim SM,Na DL,Huh GY,Lee MC,Suh YL</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to develop provisional guidelines for brain autopsy for hospitals and institutes that have not accumulated sufficient expertise.</div> <div itemprodp="datePublished">Fri Sep 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28013122"> <div itemprop="name">Development of [<sup>11</sup>C]/[<sup>3</sup>H]THK-5351 - A potential novel carbon-11 tau imaging PET radioligand.</div> </a> <div itemprop="about">Nuclear medicine and biology</div> <div itemprop="author">Stepanov V,Svedberg M,Jia Z,Krasikova R,Lemoine L,Okamura N,Furumoto S,Mitsios N,Mulder J,Långström B,Nordberg A,Halldin C</div> <div itemprop="description">MN1020 was used in immunohistochemistry - frozen section to design a [11C]THK-5351 structure for selectively imaging tau protein aggregates</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28383037"> <div itemprop="name">Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Li JG,Barrero C,Merali S,Praticò D</div> <div itemprop="description">MN1020 was used in immunohistochemistry and western blot to show that ALOX5 upregulation results in homocysteine-dependent worsening of the Alzheimer's disease phenotype</div> <div itemprodp="datePublished">Thu Apr 06 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28674493"> <div itemprop="name">A Systematic Strategy for Discovering a Therapeutic Drug for Alzheimer's Disease and Its Target Molecule.</div> </a> <div itemprop="about">Frontiers in pharmacology</div> <div itemprop="author">Yang Z,Kuboyama T,Tohda C</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to report a systematic strategy for evaluating the bioactive candidates in natural medicines used for Alzheimer's disease.</div> <div itemprodp="datePublished">Tue Aug 22 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29060936"> <div itemprop="name">Overexpression of Kinesin Superfamily Motor Proteins in Alzheimer's Disease.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Hares K,Miners JS,Cook AJ,Rice C,Scolding N,Love S,Wilkins A</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to conclude that upregulation of KIFs may be an adaptive response to impaired axonal transport in Alzheimer's disease (AD).</div> <div itemprodp="datePublished">Mon Jul 23 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28287136"> <div itemprop="name">A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Trzeciakiewicz H,Tseng JH,Wander CM,Madden V,Tripathy A,Yuan CX,Cohen TJ</div> <div itemprop="description">MN1020 was used in immunocytochemistry and western blot to study the mechanisms of pathogenesis via tau acetylation in Alzheimer's disease</div> <div itemprodp="datePublished">Mon Mar 13 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28492240"> <div itemprop="name">Tau association with synaptic vesicles causes presynaptic dysfunction.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Zhou L,McInnes J,Wierda K,Holt M,Herrmann AG,Jackson RJ,Wang YC,Swerts J,Beyens J,Miskiewicz K,Vilain S,Dewachter I,Moechars D,De Strooper B,Spires-Jones TL,De Wit J,Verstreken P</div> <div itemprop="description">MN1020 was used in Western Blotting to demonstrate that pathogenic Tau binds to synaptic vesicles via its N-terminal domain and interferes with presynaptic functions.</div> <div itemprodp="datePublished">Thu May 11 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28566250"> <div itemprop="name">Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation.</div> </a> <div itemprop="about">EBioMedicine</div> <div itemprop="author">Kobayashi S,Tanaka T,Soeda Y,Almeida OFX,Takashima A</div> <div itemprop="description">MN1020 was used in Immunocytochemistry to demonstrate that alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid and N-methyl-d-aspartate stimulation redistributes tau to the somato-dendritic region of neurons where it may trigger neurodegeneration.</div> <div itemprodp="datePublished">Thu Jun 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28936161"> <div itemprop="name">Oxidative Stress Modifies the Levels and Phosphorylation State of Tau Protein in Human Fibroblasts.</div> </a> <div itemprop="about">Frontiers in neuroscience</div> <div itemprop="author">Ibáñez-Salazar A,Bañuelos-Hernández B,Rodríguez-Leyva I,Chi-Ahumada E,Monreal-Escalante E,Jiménez-Capdeville ME,Rosales-Mendoza S</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to represent a useful model for studying the physiopathology of AD at the cellular level in terms of tau protein implications.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28650319"> <div itemprop="name">Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Wang H,Muiznieks LD,Ghosh P,Williams D,Solarski M,Fang A,Ruiz-Riquelme A,Pomès R,Watts JC,Chakrabartty A,Wille H,Sharpe S,Schmitt-Ulms G</div> <div itemprop="description">MN1020 was used in Western Blotting to identify proteins in human brain extract that bind to oligomeric Aβ1-42 (oAβ1-42) and/or monomeric Aβ1-42 (mAβ1-42) baits.</div> <div itemprodp="datePublished">Mon Jun 26 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29051562"> <div itemprop="name">Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Lathuilière A,Valdés P,Papin S,Cacquevel M,Maclachlan C,Knott GW,Muhs A,Paganetti P,Schneider BL</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to demonstrate that motifs that are critical for tau conformation determine interaction with microtubules and subsequent pathological modifications.</div> <div itemprodp="datePublished">Thu Oct 19 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29051562"> <div itemprop="name">Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Lathuilière A,Valdés P,Papin S,Cacquevel M,Maclachlan C,Knott GW,Muhs A,Paganetti P,Schneider BL</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to demonstrate that motifs that are critical for tau conformation determine interaction with microtubules and subsequent pathological modifications.</div> <div itemprodp="datePublished">Thu Oct 19 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28491492"> <div itemprop="name">Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7 T MRI.</div> </a> <div itemprop="about">NeuroImage. Clinical</div> <div itemprop="author">Blanken AE,Hurtz S,Zarow C,Biado K,Honarpisheh H,Somme J,Brook J,Tung S,Kraft E,Lo D,Ng DW,Vinters HV,Apostolova LG</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to evaluate the efficacy of hippocampal neuroimaging as a means of assessing Alzheimer's disease.</div> <div itemprodp="datePublished">Fri Mar 02 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28972160"> <div itemprop="name">An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Boselli M,Lee BH,Robert J,Prado MA,Min SW,Cheng C,Silva MC,Seong C,Elsasser S,Hatle KM,Gahman TC,Gygi SP,Haggarty SJ,Gan L,King RW,Finley D</div> <div itemprop="description">MN1020 was used in Western Blotting to identify a potent USP14 inhibitor that retains specificity for USP14.</div> <div itemprodp="datePublished">Fri Nov 24 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28599675"> <div itemprop="name">YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Querol-Vilaseca M,Colom-Cadena M,Pegueroles J,San Martín-Paniello C,Clarimon J,Belbin O,Fortea J,Lleó A</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to demonstrate that that YKL-40 is expressed by an astrocyte subset in tauopathies such as Alzheimer's disease.</div> <div itemprodp="datePublished">Fri Jun 09 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28345579"> <div itemprop="name">Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Zhang Z,Obianyo O,Dall E,Du Y,Fu H,Liu X,Kang SS,Song M,Yu SP,Cabrele C,Schubert M,Li X,Wang JZ,Brandstetter H,Ye K</div> <div itemprop="description">MN1020 was used in immunohistochemistry to evaluate the efficacy of an orally bioactive and brain permeable gamma-secretase inhibitor in a mouse model of Alzheimer's disease</div> <div itemprodp="datePublished">Mon Mar 27 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28768549"> <div itemprop="name">Intranasal insulin reverts central pathology and cognitive impairment in diabetic mother offspring.</div> </a> <div itemprop="about">Molecular neurodegeneration</div> <div itemprop="author">Ramos-Rodriguez JJ,Sanchez-Sotano D,Doblas-Marquez A,Infante-Garcia C,Lubian-Lopez S,Garcia-Alloza M</div> <div itemprop="description">MN1020 was used in Western Blotting to analyse the central long-term complications in the offspring from CD1 diabetic mothers treated with streptozotozin.</div> <div itemprodp="datePublished">Wed Aug 02 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27291520"> <div itemprop="name">Characterisation of interface astroglial scarring in the human brain after blast exposure: a post-mortem case series.</div> </a> <div itemprop="about">The Lancet. Neurology</div> <div itemprop="author">Shively SB,Horkayne-Szakaly I,Jones RV,Kelly JP,Armstrong RC,Perl DP</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to study the human brain after blast exposure in post-mortem cases to characterize the interface astroglial scarring</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27322420"> <div itemprop="name">Neuronal activity enhances tau propagation and tau pathology in vivo.</div> </a> <div itemprop="about">Nature neuroscience</div> <div itemprop="author">Wu JW,Hussaini SA,Bastille IM,Rodriguez GA,Mrejeru A,Rilett K,Sanders DW,Cook C,Fu H,Boonen RA,Herman M,Nahmani E,Emrani S,Figueroa YH,Diamond MI,Clelland CL,Wray S,Duff KE</div> <div itemprop="description">MN1020 was used in Immunofluorescence to demonstrate that increased neuronal activity stimulates the release of tau in vitro and enhances tau pathology in vivo.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26327235"> <div itemprop="name">Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease.</div> </a> <div itemprop="about">Alzheimer's & dementia : the journal of the Alzheimer's Association</div> <div itemprop="author">Montine TJ,Monsell SE,Beach TG,Bigio EH,Bu Y,Cairns NJ,Frosch M,Henriksen J,Kofler J,Kukull WA,Lee EB,Nelson PT,Schantz AM,Schneider JA,Sonnen JA,Trojanowski JQ,Vinters HV,Zhou XH,Hyman BT</div> <div itemprop="description">MN1020 was used in immunohistochemistry to characterize the neuropathologic evaluation of Alzheimer's disease by multisite assessment of NIA-AA guidelines</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27327541"> <div itemprop="name">Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice.</div> </a> <div itemprop="about">Alzheimer's & dementia : the journal of the Alzheimer's Association</div> <div itemprop="author">Herring A,Münster Y,Akkaya T,Moghaddam S,Deinsberger K,Meyer J,Zahel J,Sanchez-Mendoza E,Wang Y,Hermann DM,Arzberger T,Teuber-Hanselmann S,Keyvani K</div> <div itemprop="description">MN1020 was used in western blot to study the attenuation of Alzheimer's pathology in mice due to kallikrein-8 inhibition</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26739002"> <div itemprop="name">Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Vasconcelos B,Stancu IC,Buist A,Bird M,Wang P,Vanoosthuyse A,Van Kolen K,Verheyen A,Kienlen-Campard P,Octave JN,Baatsen P,Moechars D,Dewachter I</div> <div itemprop="description">MN1020 was used in Western Blotting to demonstrate that pre-aggregated beta-amyloid can induce Tau fibrillisation by cross-seeding.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26657517"> <div itemprop="name">Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Müller-Schiffmann A,Herring A,Abdel-Hafiz L,Chepkova AN,Schäble S,Wedel D,Horn AH,Sticht H,de Souza Silva MA,Gottmann K,Sergeeva OA,Huston JP,Keyvani K,Korth C</div> <div itemprop="description">MN1020 was used in western blot to assess the impairment in synaptic plasticity and learning due to amyloid-beta dimers in the absence of plaque pathology</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26787453"> <div itemprop="name">Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Peng Y,Kim MJ,Hullinger R,O'Riordan KJ,Burger C,Pehar M,Puglielli L</div> <div itemprop="description">MN1020 was used in immunohistochemistry and western blot to assess rescue of Alzheimer's disease in the mouse by improved proteostasis in the secretory pathway</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26988102"> <div itemprop="name">Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.</div> </a> <div itemprop="about">EMBO molecular medicine</div> <div itemprop="author">Kretner B,Trambauer J,Fukumori A,Mielke J,Kuhn PH,Kremmer E,Giese A,Lichtenthaler SF,Haass C,Arzberger T,Steiner H</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study the generation and deposition of AΒ43 by the virtually inactive presenilin-1 L435F mutant in familial Alzheimer's Disease.</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26077691"> <div itemprop="name">Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice.</div> </a> <div itemprop="about">Molecular psychiatry</div> <div itemprop="author">Di Meco A,Joshi YB,Lauretti E,Praticò D</div> <div itemprop="description">MN1020 was used in western blot to study amelioration of tau pathology and cognition in the offspring of triple transgenic AD mice by maternal dexamethasone exposure</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27427974"> <div itemprop="name">Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.</div> </a> <div itemprop="about">Autophagy</div> <div itemprop="author">Pajares M,Jiménez-Moreno N,García-Yagüe ÁJ,Escoll M,de Ceballos ML,Van Leuven F,Rábano A,Yamamoto M,Rojo AI,Cuadrado A</div> <div itemprop="description">MN1020 was used in immunohistochemistry - free floating to identify NFE2L2/NRF2 as a regulator of autophagy gene expression and study its role in Alzheimer disease</div> <div itemprodp="datePublished">Sun Oct 02 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27406053"> <div itemprop="name">Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein.</div> </a> <div itemprop="about">Aging cell</div> <div itemprop="author">Manassero G,Guglielmotto M,Zamfir R,Borghi R,Colombo L,Salmona M,Perry G,Odetti P,Arancio O,Tamagno E,Tabaton M</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section elucidate the mechanistic relationship between amyloid beta1-42 and Tau</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25763997"> <div itemprop="name">Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease.</div> </a> <div itemprop="about">Brain pathology (Zurich, Switzerland)</div> <div itemprop="author">Tapia-Rojas C,Aranguiz F,Varela-Nallar L,Inestrosa NC</div> <div itemprop="description">MN1020 was used in immunohistochemistry to assess the effect of voluntary running on several aspects of Alzheimer's disease</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27312772"> <div itemprop="name">Late running is not too late against Alzheimer's pathology.</div> </a> <div itemprop="about">Neurobiology of disease</div> <div itemprop="author">Herring A,Münster Y,Metzdorf J,Bolczek B,Krüssel S,Krieter D,Yavuz I,Karim F,Roggendorf C,Stang A,Wang Y,Hermann DM,Teuber-Hanselmann S,Keyvani K</div> <div itemprop="description">MN1020 was used in immunohistochemistry and western blot to It is never too late to start late running regarding Alzheimer's pathology</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26777665"> <div itemprop="name">Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice.</div> </a> <div itemprop="about">Neurobiology of disease</div> <div itemprop="author">El Khoury NB,Gratuze M,Petry F,Papon MA,Julien C,Marcouiller F,Morin F,Nicholls SB,Calon F,Hébert SS,Marette A,Planel E</div> <div itemprop="description">MN1020 was used in western blot to examine the impact of type 2 diabetes on tau phosphorylation in diabetic mouse model</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27260836"> <div itemprop="name">Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease.</div> </a> <div itemprop="about">Neurobiology of disease</div> <div itemprop="author">Ando K,Tomimura K,Sazdovitch V,Suain V,Yilmaz Z,Authelet M,Ndjim M,Vergara C,Belkouch M,Potier MC,Duyckaerts C,Brion JP</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to assess the correlation with levels of phosphotau and autophagy-related proteins and tau inclusions in PSP, Pick, and AD disease and levels of a key component of clathrin-mediated endocytosis,</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26549854"> <div itemprop="name">Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer's mice.</div> </a> <div itemprop="about">Neuropharmacology</div> <div itemprop="author">Sabogal-Guáqueta AM,Osorio E,Cardona-Gómez GP</div> <div itemprop="description">MN1020 was used in immunohistochemistry to characterize linalool that reverses behavioral and neuropathological impairments in old triple transgenic Alzheimer's mice</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26802771"> <div itemprop="name">TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice.</div> </a> <div itemprop="about">Neuropharmacology</div> <div itemprop="author">Jiang T,Zhang YD,Chen Q,Gao Q,Zhu XC,Zhou JS,Shi JQ,Lu H,Tan L,Yu JT</div> <div itemprop="description">MN1020 was used in immunohistochemistry and western blot to elucidate modification microglial phenotype and neuroprotection in P301S tau transgenic mice via TREM2</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26867503"> <div itemprop="name">(I) Pharmacological profiling of a novel modulator of the α7 nicotinic receptor: Blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer brains.</div> </a> <div itemprop="about">Neuropharmacology</div> <div itemprop="author">Garcia-Ratés S,Morrill P,Tu H,Pottiez G,Badin AS,Tormo-Garcia C,Heffner C,Coen CW,Greenfield SA</div> <div itemprop="description">MN1020 was used in western blot to research blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer's brains by pharmacological profiling of the novel modulator of the alpha7 nicotinic receptor</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26923416"> <div itemprop="name">Early Alzheimer's disease-type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei).</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Perez SE,Sherwood CC,Cranfield MR,Erwin JM,Mudakikwa A,Hof PR,Mufson EJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry - free floating to characterize the frontal cortex of wild mountain gorillas (Gorilla beringei beringei) for early Alzheimer's disease-type pathology</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26923018"> <div itemprop="name">Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Guillot F,Kemppainen S,Lavasseur G,Miettinen PO,Laroche S,Tanila H,Davis S</div> <div itemprop="description">MN1020 was used in western blot to study novelty-induced and brain-specific basal alternations in PI3K-Akt and MAPK/ERK signaling in a middle-aged A-betaPP/PS1 mouse model of Alzheimer's disease</div> <div itemprodp="datePublished">Thu Dec 29 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26701291"> <div itemprop="name">Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease.</div> </a> <div itemprop="about">Neuroscience</div> <div itemprop="author">Platt TL,Beckett TL,Kohler K,Niedowicz DM,Murphy MP</div> <div itemprop="description">MN1020 was used in western blot to characterize tau pathology mouse models via obesity, diabetes, and leptin resistance</div> <div itemprodp="datePublished">Fri Feb 19 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26613607"> <div itemprop="name">Locus ceruleus neurons in people with autism contain no histochemically-detectable mercury.</div> </a> <div itemprop="about">Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine</div> <div itemprop="author">Pamphlett R,Kum Jew S</div> <div itemprop="description">MN1020 was used in immunohistochemistry to discover why mercury is found in locus ceruleus neurons in people with autism</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27346750"> <div itemprop="name">Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Adams SL,Tilton K,Kozubek JA,Seshadri S,Delalle I</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to characterize the cerebral cortex during the progression of Alzheimer disease pathology by visualizing subcellular changes in bridging integrator 1 protein expression</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26827932"> <div itemprop="name">Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia.</div> </a> <div itemprop="about">Neurobiology of learning and memory</div> <div itemprop="author">Van der Jeugd A,Vermaercke B,Halliday GM,Staufenbiel M,Götz J</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to elucidate a mouse model of frontotemporal dementia by decreased social exploration, impulsivity, and executive dysfunction</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26239295"> <div itemprop="name">Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment.</div> </a> <div itemprop="about">The Journal of comparative neurology</div> <div itemprop="author">Smolek T,Madari A,Farbakova J,Kandrac O,Jadhav S,Cente M,Brezovakova V,Novak M,Zilka N</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to study canine cognitive impairment syndrome.</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26293308"> <div itemprop="name">Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease.</div> </a> <div itemprop="about">Neuropathology : official journal of the Japanese Society of Neuropathology</div> <div itemprop="author">Mizukami K,Akatsu H,Abrahamson EE,Mi Z,Ikonomovic MD</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to demonstrate that in Alzheimer's disease hippocampus, BChE accumulates in neurons and plaque-associated neuritic clusters, but only in a small proportion of neurofibrillary tangles.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26685795"> <div itemprop="name">Hypersialylation is a common feature of neurofibrillary tangles and granulovacuolar degenerations in Alzheimer's disease and tauopathy brains.</div> </a> <div itemprop="about">Neuropathology : official journal of the Japanese Society of Neuropathology</div> <div itemprop="author">Nagamine S,Yamazaki T,Makioka K,Fujita Y,Ikeda M,Takatama M,Okamoto K,Yokoo H,Ikeda Y</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to analysis of neurofibrillary tangles and granulovacuolar degeneration in Alzheimer's disease and tauopathy brains and the common feature of hypersialylation</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27339073"> <div itemprop="name">Increased tauopathy drives microglia-mediated clearance of beta-amyloid.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Chen W,Abud EA,Yeung ST,Lakatos A,Nassi T,Wang J,Blum D,Buée L,Poon WW,Blurton-Jones M</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to study the interplay between AΒ deposition, tau pathology and microgliosis in Alzheimer's disease.</div> <div itemprodp="datePublished">Thu Jun 23 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29067301"> <div itemprop="name">NPT088 reduces both amyloid-β and tau pathologies in transgenic mice.</div> </a> <div itemprop="about">Alzheimer's & dementia (New York, N. Y.)</div> <div itemprop="author">Levenson JM,Schroeter S,Carroll JC,Cullen V,Asp E,Proschitsky M,Chung CH,Gilead S,Nadeem M,Dodiya HB,Shoaga S,Mufson EJ,Tsubery H,Krishnan R,Wright J,Solomon B,Fisher R,Gannon KS</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to establish NPT088 as a novel therapeutic approach and potential drug class that targets both Aβ and tau.</div> <div itemprodp="datePublished">Thu Sep 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27955679"> <div itemprop="name">Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Ikonomovic MD,Buckley CJ,Heurling K,Sherwin P,Jones PA,Zanette M,Mathis CA,Klunk WE,Chakrabarty A,Ironside J,Ismail A,Smith C,Thal DR,Beach TG,Farrar G,Smith AP</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to support that amyloid in neuritic plaque burden is the primary form of Β-amyloid pathology detectable with [18F]flutemetamol PET imaging.</div> <div itemprodp="datePublished">Mon Dec 12 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27149947"> <div itemprop="name">Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Villaseñor R,Ozmen L,Messaddeq N,Grüninger F,Loetscher H,Keller A,Betsholtz C,Freskgård PO,Collin L</div> <div itemprop="description">MN1020 was used in Immunofluorescence in immunohistochemistry on frozen tissues to suggest that immunoglobulin (IgG) lysosomal degradation may be a downstream mechanism by which brain endothelial cells further restrict IgG access to the brain.</div> <div itemprodp="datePublished">Fri May 06 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27044537"> <div itemprop="name">Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Kawakami I,Kobayashi Z,Arai T,Yokota O,Nonaka T,Aoki N,Niizato K,Oshima K,Higashi S,Katsuse O,Hosokawa M,Hasegawa M,Akiyama H</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to suggest that the clinical feature of choreoathetosis in behavioral variant of frontotemporal dementia might be associated with the basophilic inclusion body disease subtype of frontotemporal lobar degeneration</div> <div itemprodp="datePublished">Mon Apr 04 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26235064"> <div itemprop="name">Protocols for Monitoring the Development of Tau Pathology in Alzheimer's Disease.</div> </a> <div itemprop="about">Methods in molecular biology (Clifton, N.J.)</div> <div itemprop="author">Rábano A,Cuadros R,Merino-Serráis P,Rodal I,Benavides-Piccione R,Gómez E,Medina M,DeFelipe J,Avila J</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section and western blot to discuss protocols that monitor tau pathology development in Alzheimer's disease</div> <div itemprodp="datePublished">Fri Apr 29 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27356871"> <div itemprop="name">Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.</div> </a> <div itemprop="about">Molecular neurodegeneration</div> <div itemprop="author">Sohn PD,Tracy TE,Son HI,Zhou Y,Leite RE,Miller BL,Seeley WW,Grinberg LT,Gan L</div> <div itemprop="description">MN1020 was used in western blot to investigate the axon initial segment in neurological disorders</div> <div itemprodp="datePublished">Wed Jun 29 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26982086"> <div itemprop="name">Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Blair JA,Wang C,Hernandez D,Siedlak SL,Rodgers MS,Achar RK,Fahmy LM,Torres SL,Petersen RB,Zhu X,Casadesus G,Lee HG</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence and Western Blotting to assess the impact of postmortem interval time on brain tissue preservation.</div> <div itemprodp="datePublished">Mon Jul 25 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26982086"> <div itemprop="name">Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Blair JA,Wang C,Hernandez D,Siedlak SL,Rodgers MS,Achar RK,Fahmy LM,Torres SL,Petersen RB,Zhu X,Casadesus G,Lee HG</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence and Western Blotting to assess the impact of postmortem interval time on brain tissue preservation.</div> <div itemprodp="datePublished">Mon Jul 25 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26732432"> <div itemprop="name">Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer's disease pathology.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Rosenberger AF,Morrema TH,Gerritsen WH,van Haastert ES,Snkhchyan H,Hilhorst R,Rozemuller AJ,Scheltens P,van der Vies SM,Hoozemans JJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry to analyze astrocytes in Alzheimer's disease pathology by an increased occurrence of protein kinase CK2</div> <div itemprodp="datePublished">Wed Jan 06 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27906174"> <div itemprop="name">Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Lipton SA,Rezaie T,Nutter A,Lopez KM,Parker J,Kosaka K,Satoh T,McKercher SR,Masliah E,Nakanishi N</div> <div itemprop="description">MN1020 was used in immunohistochemistry to examine the effects of carnosic acid in models of Alzheimer's disease</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27257626"> <div itemprop="name">TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits.</div> </a> <div itemprop="about">eNeuro</div> <div itemprop="author">Wang H,Wang R,Carrera I,Xu S,Lakshmana MK</div> <div itemprop="description">MN1020 was used in western blot to analyze the mitigation that increases PHF1 levels and lipofuscin puncta and rescues memory deficits by TFEB overexpression in the P301S model of tauopathy</div> <div itemprodp="datePublished">Fri Oct 20 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26940749"> <div itemprop="name">Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Gorsky MK,Burnouf S,Dols J,Mandelkow E,Partridge L</div> <div itemprop="description">MN1020 was used in western blot to elucidate the exacerbation of human Tau neurotoxicity in vivo by acetylation mimic of lysine 280</div> <div itemprodp="datePublished">Fri Mar 04 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27090093"> <div itemprop="name">High Resolution Dissection of Reactive Glial Nets in Alzheimer's Disease.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Bouvier DS,Jones EV,Quesseveur G,Davoli MA,A Ferreira T,Quirion R,Mechawar N,Murai KK</div> <div itemprop="description">MN1020 was used in immunohistochemistry - free floating to analyze reactive glial nets in Alzheimer's disease by high resolution dissection</div> <div itemprodp="datePublished">Tue Apr 19 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27605042"> <div itemprop="name">Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Mansuroglu Z,Benhelli-Mokrani H,Marcato V,Sultan A,Violet M,Chauderlier A,Delattre L,Loyens A,Talahari S,Bégard S,Nesslany F,Colin M,Souès S,Lefebvre B,Buée L,Galas MC,Bonnefoy E</div> <div itemprop="description">MN1020 was used in immunohistochemistry to suggest that Tau regulates neuronal pericentromeric heterochromatin integrity</div> <div itemprodp="datePublished">Thu Sep 08 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27475227"> <div itemprop="name">Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Lee SH,Le Pichon CE,Adolfsson O,Gafner V,Pihlgren M,Lin H,Solanoy H,Brendza R,Ngu H,Foreman O,Chan R,Ernst JA,DiCara D,Hotzel I,Srinivasan K,Hansen DV,Atwal J,Lu Y,Bumbaca D,Pfeifer A,Watts RJ,Muhs A,Scearce-Levie K,Ayalon G</div> <div itemprop="description">MN1020 was used in Western Blot to investigate whether antibody effector function is required for targeting tau.</div> <div itemprodp="datePublished">Tue Aug 09 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27531128"> <div itemprop="name">Diminishing evidence for torsinA-positive neuronal inclusions in DYT1 dystonia.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Pratt D,Mente K,Rahimpour S,Edwards NA,Tinaz S,Berman BD,Hallett M,Ray-Chaudhury A</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to add to the growing body of evidence that there are no consistent torsinA immunoreactive protein inclusions associated with, or specific to, DYT1 dystonia in humans.</div> <div itemprodp="datePublished">Wed Aug 17 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26202523"> <div itemprop="name">Unfolded protein response is activated in Lewy body dementias.</div> </a> <div itemprop="about">Neuropathology and applied neurobiology</div> <div itemprop="author">Baek JH,Whitfield D,Howlett D,Francis P,Bereczki E,Ballard C,Hortobágyi T,Attems J,Aarsland D</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to give emphasis to the role of UPR in Lewy body dementias, and suggest that Lewy body degeneration, in combination with AD-type pathologies, is associated with increased UPR activation to a greater extent than AD alone, possibly as a consequence of the increasing load of ER proteins.</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25761889"> <div itemprop="name">Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model.</div> </a> <div itemprop="about">Science translational medicine</div> <div itemprop="author">Leinenga G,Götz J</div> <div itemprop="description">MN1020 was used in western blot to explore a nonpharmacological approach, repeated scanning ultrasound treatments, for removing Abeta and restoring memory function in a mouse model of Alzheimer's disease</div> <div itemprodp="datePublished">Wed Mar 11 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25732305"> <div itemprop="name">TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Jay TR,Miller CM,Cheng PJ,Graham LC,Bemiller S,Broihier ML,Xu G,Margevicius D,Karlo JC,Sousa GL,Cotleur AC,Butovsky O,Bekris L,Staugaitis SM,Leverenz JB,Pimplikar SW,Landreth GE,Howell GR,Ransohoff RM,Lamb BT</div> <div itemprop="description">MN1020 was used in immunohistochemistry - free floating to elucidate the cell types and mechanisms underlying TREM2's contribution to neurodegeneration.</div> <div itemprodp="datePublished">Mon Mar 09 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26068894"> <div itemprop="name">A 3D human neural cell culture system for modeling Alzheimer's disease.</div> </a> <div itemprop="about">Nature protocols</div> <div itemprop="author">Kim YH,Choi SH,D'Avanzo C,Hebisch M,Sliwinski C,Bylykbashi E,Washicosky KJ,Klee JB,Brüstle O,Tanzi RE,Kim DY</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to provide instructions for the generation and analysis of 3D human neural cell cultures.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25620800"> <div itemprop="name">Relationship between hippocampal atrophy and neuropathology markers: a 7T MRI validation study of the EADC-ADNI Harmonized Hippocampal Segmentation Protocol.</div> </a> <div itemprop="about">Alzheimer's & dementia : the journal of the Alzheimer's Association</div> <div itemprop="author">Apostolova LG,Zarow C,Biado K,Hurtz S,Boccardi M,Somme J,Honarpisheh H,Blanken AE,Brook J,Tung S,Lo D,Ng D,Alger JR,Vinters HV,Bocchetta M,Duvernoy H,Jack CR,Frisoni GB</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to validate the European Alzheimer's Disease Consortium Alzheimer's Disease Neuroimaging Initiative Center Harmonized Hippocampal Segmentation Protocol (HarP).</div> <div itemprodp="datePublished">Sun Feb 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26141264"> <div itemprop="name">[(18)F]flutemetamol amyloid positron emission tomography in preclinical and symptomatic Alzheimer's disease: specific detection of advanced phases of amyloid-β pathology.</div> </a> <div itemprop="about">Alzheimer's & dementia : the journal of the Alzheimer's Association</div> <div itemprop="author">Thal DR,Beach TG,Zanette M,Heurling K,Chakrabarty A,Ismail A,Smith AP,Buckley C</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to evaluate the diagnostic value of the amyloid positron emission tomography tracer, [(18)F]flutemetamol, in relation to AΒ pathology at autopsy.</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26439832"> <div itemprop="name">Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Wagner J,Krauss S,Shi S,Ryazanov S,Steffen J,Miklitz C,Leonov A,Kleinknecht A,Göricke B,Weishaupt JH,Weckbecker D,Reiner AM,Zinth W,Levin J,Ehninger D,Remy S,Kretzschmar HA,Griesinger C,Giese A,Fuhrmann M</div> <div itemprop="description">MN1020 was used in immunohistochemistry and western blot to report that the di-phenyl-pyrazole anle138b binds to and inhibits tau aggregation in vitro and in vivo</div> <div itemprodp="datePublished">Sun Nov 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25833819"> <div itemprop="name">Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Maphis N,Xu G,Kokiko-Cochran ON,Jiang S,Cardona A,Ransohoff RM,Lamb BT,Bhaskar K</div> <div itemprop="description">MN1020 was used in western blot to demonstrate that microglia promote tau pathology in a cell-autonomous manner.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25842390"> <div itemprop="name">HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Sepulveda-Diaz JE,Alavi Naini SM,Huynh MB,Ouidja MO,Yanicostas C,Chantepie S,Villares J,Lamari F,Jospin E,van Kuppevelt TH,Mensah-Nyagan AG,Raisman-Vozari R,Soussi-Yanicostas N,Papy-Garcia D</div> <div itemprop="description">MN1020 was used in western blot to characterize Alzheimer's disease-related tau pathology by HS3ST2 expression in critical for the abonormal phosphorylation of tau</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25103200"> <div itemprop="name">Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias.</div> </a> <div itemprop="about">Brain pathology (Zurich, Switzerland)</div> <div itemprop="author">Howlett DR,Whitfield D,Johnson M,Attems J,O'Brien JT,Aarsland D,Lai MK,Lee JH,Chen C,Ballard C,Hortobágyi T,Francis PT</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to show that cognitive decline in Lewy body dementias is due to a combination of α-synuclein-induced neurodegeneration, senile plaque and phosphorylated tau pathology.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26385829"> <div itemprop="name">Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo.</div> </a> <div itemprop="about">Neurobiology of disease</div> <div itemprop="author">Violet M,Chauderlier A,Delattre L,Tardivel M,Chouala MS,Sultan A,Marciniak E,Humez S,Binder L,Kayed R,Lefebvre B,Bonnefoy E,Buée L,Galas MC</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to determine the therapeutic window to prevent the formation of Tau aggregates</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25632141"> <div itemprop="name">The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Spilsbury A,Miwa S,Attems J,Saretzki G</div> <div itemprop="description">MN1020 was used in immunocytochemistry and immunohistochemistry - paraffin section to investigate the role of TERT in the adult human brain</div> <div itemprodp="datePublished">Wed Jan 28 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26538654"> <div itemprop="name">Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Hunt JB,Nash KR,Placides D,Moran P,Selenica ML,Abuqalbeen F,Ratnasamy K,Slouha N,Rodriguez-Ospina S,Savlia M,Ranaweera Y,Reid P,Dickey CA,Uricia R,Yang CG,Sandusky LA,Gordon MN,Morgan D,Lee DC</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study the effects of Arginase 1 overexperssion in the central nervous system of rTg4510 tau transgenic mice.</div> <div itemprodp="datePublished">Wed Nov 04 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25727649"> <div itemprop="name">At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei.</div> </a> <div itemprop="about">Neuropathology and applied neurobiology</div> <div itemprop="author">Reis R,Hennessy E,Murray C,Griffin ÉW,Cunningham C</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to investigate the spread of neuronal pathology.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25747037"> <div itemprop="name">The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">Experimental neurology</div> <div itemprop="author">Collins JM,King AE,Woodhouse A,Kirkcaldie MT,Vickers JC</div> <div itemprop="description">MN1020 was used in immunohistochemistry - free floating to use the APP/PS1 (APPSWE, PSEN1dE9) transgenic model of Alzheimer's disease to study the role of localized damage on disease progression</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26118667"> <div itemprop="name">Activation of Cdk5/p25 and tau phosphorylation following chronic brain hypoperfusion in rats involves microRNA-195 down-regulation.</div> </a> <div itemprop="about">Journal of neurochemistry</div> <div itemprop="author">Sun LH,Ban T,Liu CD,Chen QX,Wang X,Yan ML,Hu XL,Su XL,Bao YN,Sun LL,Zhao LJ,Pei SC,Jiang XM,Zong DK,Ai J</div> <div itemprop="description">MN1020 was used in western blot to investigate the involvement of microRNA-195 in the effect of chronic brain hypoperfusion on rodent Cdk5/p25 and tau phosphorylation</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25041093"> <div itemprop="name">Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice.</div> </a> <div itemprop="about">Journal of neurochemistry</div> <div itemprop="author">Ittner A,Bertz J,Suh LS,Stevens CH,Götz J,Ittner LM</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section and western blot to determine the pathology in tau transgenic mice due to tau-targeting passive immunization</div> <div itemprodp="datePublished">Thu Jan 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25666032"> <div itemprop="name">The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice.</div> </a> <div itemprop="about">Neuropharmacology</div> <div itemprop="author">Sabogal-Guáqueta AM,Muñoz-Manco JI,Ramírez-Pineda JR,Lamprea-Rodriguez M,Osorio E,Cardona-Gómez GP</div> <div itemprop="description">MN1020 was used in immunohistochemistry and western blot to assess the neuroprotective effect of quercetin administration in the triple transgenic Alzheimer's disease model mice</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25457549"> <div itemprop="name">Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Lauretti E,Di Meco A,Chu J,Praticò D</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section and western blot to characterize the behavioral, biochemical, and neuropathologic effects of 8ISO in the triple transgenic mouse model of Alzheimer's disease</div> <div itemprodp="datePublished">Sun Feb 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25595497"> <div itemprop="name">Aneuploidy in Lewy body diseases.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Yang Y,Shepherd C,Halliday G</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to evaluate the role of DNA content in Lewy body diseases</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25616912"> <div itemprop="name">Isolation and characterization of antibody fragments selective for toxic oligomeric tau.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Tian H,Davidowitz E,Lopez P,He P,Schulz P,Moe J,Sierks MR</div> <div itemprop="description">MN1020 was used in ELISA to generate reagents that selectively recognize toxic oligomeric tau</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26362250"> <div itemprop="name">miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Smith PY,Hernandez-Rapp J,Jolivette F,Lecours C,Bisht K,Goupil C,Dorval V,Parsi S,Morin F,Planel E,Bennett DA,Fernandez-Gomez FJ,Sergeant N,Buée L,Tremblay MÈ,Calon F,Hébert SS</div> <div itemprop="description">MN1020 was used in western blot to investigate the role of miR-132/212 in tauopathies</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26123245"> <div itemprop="name">Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2.</div> </a> <div itemprop="about">Journal of neuroscience research</div> <div itemprop="author">Hamm M,Bailey R,Shaw G,Yen SH,Lewis J,Giasson BI</div> <div itemprop="description">MN1020 was used in western blot to study how microtubules and cations impact LRRK2-tau interactions.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25547633"> <div itemprop="name">Different Populations of Human Locus Ceruleus Neurons Contain Heavy Metals or Hyperphosphorylated Tau: Implications for Amyloid-β and Tau Pathology in Alzheimer's Disease.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Pamphlett R,Kum Jew S</div> <div itemprop="description">MN1020 was used in Immunofluorescence in immunohistochemistry on frozen tissues to describe a model that proposes that the locus ceruleus plays a part in both the amyloid-Β and tau pathologies of Alzheimer's disease.</div> <div itemprodp="datePublished">Thu Jan 14 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25374108"> <div itemprop="name">Dexmedetomidine directly increases tau phosphorylation.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Huang C,Ho YS,Ng OT,Irwin MG,Chang RC,Wong GT</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section and western blot to study tau phosphorylation and its direct increase by dexmedetomidine</div> <div itemprodp="datePublished">Mon Oct 26 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25125468"> <div itemprop="name">Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Dunn HC,Ager RR,Baglietto-Vargas D,Cheng D,Kitazawa M,Cribbs DH,Medeiros R</div> <div itemprop="description">MN1020 was used in western blot to assess the effect of aging on brain lipoxin A4 levels using non-transgenic and 3xTg-AD mice.</div> <div itemprodp="datePublished">Fri Aug 21 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25770969"> <div itemprop="name">Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons.</div> </a> <div itemprop="about">Neuroscience</div> <div itemprop="author">Li R,Xu DE,Ma T</div> <div itemprop="description">MN1020 was used in western blot to elucidate the neuroprotective mechanism of statins</div> <div itemprodp="datePublished">Thu May 21 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26088035"> <div itemprop="name">Clinico-Pathological Correlations of the Frontal Lobe Syndrome: Results of a Large Brain Bank Study.</div> </a> <div itemprop="about">Dementia and geriatric cognitive disorders</div> <div itemprop="author">Krudop WA,Bosman S,Geurts JJ,Sikkes SA,Verwey NA,Stek ML,Scheltens P,Rozemuller AJ,Pijnenburg YA</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to show that the distribution of pathological changes in subjects with FLS was shown to be frontal-subcortical for the first time.</div> <div itemprodp="datePublished">Thu Jan 14 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26616881"> <div itemprop="name">Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product.</div> </a> <div itemprop="about">Journal of neuroimmunology</div> <div itemprop="author">Hromadkova L,Kolarova M,Jankovicova B,Bartos A,Ricny J,Bilkova Z,Ripova D</div> <div itemprop="description">MN1020 was used in western blot to investigate the reactivity of isolated natural antibodies against tau protein</div> <div itemprodp="datePublished">Tue Dec 15 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25756588"> <div itemprop="name">Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Perez SE,He B,Nadeem M,Wuu J,Ginsberg SD,Ikonomovic MD,Mufson EJ</div> <div itemprop="description">MN1020 was used in Western Blotting to indicate that alterations in hippocampal endosomal-lysosomal proteins in mild cognitive impairment are independent of tau or Aβ pathology.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25868149"> <div itemprop="name">Correlations between mini-mental state examination score, cerebrospinal fluid biomarkers, and pathology observed in brain biopsies of patients with normal-pressure hydrocephalus.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Elobeid A,Laurell K,Cesarini KG,Alafuzoff I</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to assess Alzheimer disease-related pathology in cortical biopsy samples of 111 patients with idiopathic normal-pressure hydrocephalus.</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25575135"> <div itemprop="name">Cerebral cortical Aβ42 and PHF-τ in 325 consecutive brain autopsies stratified by diagnosis, location, and APOE.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Postupna N,Keene CD,Crane PK,Gonzalez-Cuyar LF,Sonnen JA,Hewitt J,Rice S,Howard K,Montine KS,Larson EB,Montine TJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to quantify amyloid beta 42 and paired helical filament-tau in the frontal, temporal, and parietal cortices</div> <div itemprodp="datePublished">Sun Feb 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25687633"> <div itemprop="name">Array tomography for the detection of non-dilated, injured axons in traumatic brain injury.</div> </a> <div itemprop="about">Journal of neuroscience methods</div> <div itemprop="author">Bennett RE,Brody DL</div> <div itemprop="description">MN1020 was used in immunohistochemistry to discuss the limitations assessing axonal injury by microscopy</div> <div itemprodp="datePublished">Thu Apr 30 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26164610"> <div itemprop="name">Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice.</div> </a> <div itemprop="about">Neuroreport</div> <div itemprop="author">Kim JM,Kim SS,Lee YD</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to investigate the relationship between neurofibrillary changes and degeneration of septal cholinergic neurons in P301L tau transgenic mice</div> <div itemprodp="datePublished">Wed Sep 09 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25881209"> <div itemprop="name">Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology.</div> </a> <div itemprop="about">Molecular neurodegeneration</div> <div itemprop="author">Song L,Lu SX,Ouyang X,Melchor J,Lee J,Terracina G,Wang X,Hyde L,Hess JF,Parker EM,Zhang L</div> <div itemprop="description">MN1020 was used in western blot to use rTg4510 mice to elucidate pathogenesis of tau-induced disease.</div> <div itemprodp="datePublished">Thu Mar 26 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25772164"> <div itemprop="name">Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes.</div> </a> <div itemprop="about">Biochimica et biophysica acta</div> <div itemprop="author">Filipcik P,Cente M,Zilka N,Smolek T,Hanes J,Kucerak J,Opattova A,Kovacech B,Novak M</div> <div itemprop="description">MN1020 was used in immunohistochemistry - free floating to study the involvement of heat shock protein 27 (Hsp27) in a transgenic rat model of Alzheimer's disease</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26069855"> <div itemprop="name">Reduced Number of Pigmented Neurons in the Substantia Nigra of Dystonia Patients? Findings from Extensive Neuropathologic, Immunohistochemistry, and Quantitative Analyses.</div> </a> <div itemprop="about">Tremor and other hyperkinetic movements (New York, N.Y.)</div> <div itemprop="author">Iacono D,Geraci-Erck M,Peng H,Rabin ML,Kurlan R</div> <div itemprop="description">MN1020 was used in immunohistochemistry to characterize the neuropathological features of dystonias</div> <div itemprodp="datePublished">Sat Jun 13 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26651604"> <div itemprop="name">Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation.</div> </a> <div itemprop="about">Stem cell reports</div> <div itemprop="author">Schwab AJ,Ebert AD</div> <div itemprop="description">MN1020 was used in western blot to study the effect of G2019S on neuronal subtypes</div> <div itemprodp="datePublished">Tue Dec 08 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26502977"> <div itemprop="name">Analysis of in vivo turnover of tau in a mouse model of tauopathy.</div> </a> <div itemprop="about">Molecular neurodegeneration</div> <div itemprop="author">Yamada K,Patel TK,Hochgräfe K,Mahan TE,Jiang H,Stewart FR,Mandelkow EM,Holtzman DM</div> <div itemprop="description">MN1020 was used in ELISA to study in vivo turnover of tau by use of a mouse model of tauopathy</div> <div itemprodp="datePublished">Mon Oct 26 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26293123"> <div itemprop="name">Human neural stem cells alleviate Alzheimer-like pathology in a mouse model.</div> </a> <div itemprop="about">Molecular neurodegeneration</div> <div itemprop="author">Lee IS,Jung K,Kim IS,Lee H,Kim M,Yun S,Hwang K,Shin JE,Park KI</div> <div itemprop="description">MN1020 was used in western blot to analyze a mouse model where human neural stem cells alleviate Alzheimer-like pathology</div> <div itemprodp="datePublished">Fri Aug 21 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26651821"> <div itemprop="name">The domestic cat as a natural animal model of Alzheimer's disease.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Chambers JK,Tokuda T,Uchida K,Ishii R,Tatebe H,Takahashi E,Tomiyama T,Une Y,Nakayama H</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to study Alzheimer's disease by use of a domestic cat animal model</div> <div itemprodp="datePublished">Thu Dec 10 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26720273"> <div itemprop="name">Role of Liver X Receptor in AD Pathophysiology.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Sandoval-Hernández AG,Buitrago L,Moreno H,Cardona-Gómez GP,Arboleda G</div> <div itemprop="description">MN1020 was used in immunohistochemistry to test if a LXR agonist affects cognitive impairment in amyloid and Tau Alzheimer's disease mouse models</div> <div itemprodp="datePublished">Sun Jun 26 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26335101"> <div itemprop="name">Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Henstridge CM,Jackson RJ,Kim JM,Herrmann AG,Wright AK,Harris SE,Bastin ME,Starr JM,Wardlaw J,Gillingwater TH,Smith C,McKenzie CA,Cox SR,Deary IJ,Spires-Jones TL</div> <div itemprop="description">MN1020 was used in immunohistochemistry (paraffin) to present data from the first donated Lothian Birth Cohort of 1936 and compare it with other aged and diseased samples.</div> <div itemprodp="datePublished">Fri Sep 04 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26778963"> <div itemprop="name">β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice.</div> </a> <div itemprop="about">Frontiers in cellular neuroscience</div> <div itemprop="author">Piedrahita D,Castro-Alvarez JF,Boudreau RL,Villegas-Lanau A,Kosik KS,Gallego-Gomez JC,Cardona-Gómez GP</div> <div itemprop="description">MN1020 was used in western blot to study reduction of hyperphosphorilated Tau by beta-secretase 1's targeting implying autophagy actors in 3xTg-AD mice</div> <div itemprodp="datePublished">Mon Jan 18 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26637371"> <div itemprop="name">The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease.</div> </a> <div itemprop="about">Molecular brain</div> <div itemprop="author">Watanabe K,Uemura K,Asada M,Maesako M,Akiyama H,Shimohama S,Takahashi R,Kinoshita A</div> <div itemprop="description">MN1020 was used in western blot to characterize the release of insulin-like growth factor-binding protein 3 from astrocytes in the pathology of Alzheimer's disease</div> <div itemprodp="datePublished">Fri Dec 04 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25406315"> <div itemprop="name">Conformation determines the seeding potencies of native and recombinant Tau aggregates.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Falcon B,Cavallini A,Angers R,Glover S,Murray TK,Barnham L,Jackson S,O'Neill MJ,Isaacs AM,Hutton ML,Szekeres PG,Goedert M,Bose S</div> <div itemprop="description">MN1020 was used in western blot to determine seeding potencies of recombinant and native Tau aggregates due to conformation</div> <div itemprodp="datePublished">Fri Jan 09 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26135580"> <div itemprop="name">Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Eggers SD,Horn AK,Roeber S,Härtig W,Nair G,Reich DS,Leigh RJ</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to support current models and experimental studies of the brainstem saccade-generating neurons and indicate that damage to PN may permanently impair the function of these neurons that the PN ensheathe.</div> <div itemprodp="datePublished">Tue May 03 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25745387"> <div itemprop="name">Identification of age- and disease-related alterations in circulating miRNAs in a mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">Frontiers in cellular neuroscience</div> <div itemprop="author">Garza-Manero S,Arias C,Bermúdez-Rattoni F,Vaca L,Zepeda A</div> <div itemprop="description">MN1020 was used in immunohistochemistry - free floating to investigate if circulating miRNA levels can be used as biomarkers for Alzheimer's disease</div> <div itemprodp="datePublished">Fri Mar 06 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26503418"> <div itemprop="name">Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Chauhan S,Ahmed Z,Bradfute SB,Arko-Mensah J,Mandell MA,Won Choi S,Kimura T,Blanchet F,Waller A,Mudd MH,Jiang S,Sklar L,Timmins GS,Maphis N,Bhaskar K,Piguet V,Deretic V</div> <div itemprop="description">MN1020 was used in western blot to use a pharmaceutical screen to discover new mechanisms of autophagy activation</div> <div itemprodp="datePublished">Tue Oct 27 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25038828"> <div itemprop="name">Huntington's disease is a four-repeat tauopathy with tau nuclear rods.</div> </a> <div itemprop="about">Nature medicine</div> <div itemprop="author">Fernández-Nogales M,Cabrera JR,Santos-Galindo M,Hoozemans JJ,Ferrer I,Rozemuller AJ,Hernández F,Avila J,Lucas JJ</div> <div itemprop="description">MN1020 was used in western blot to investigate the role of tau missplicing in the pathogenesis of Huntington disease</div> <div itemprodp="datePublished">Fri Aug 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24670762"> <div itemprop="name">REST and stress resistance in ageing and Alzheimer's disease.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Lu T,Aron L,Zullo J,Pan Y,Kim H,Chen Y,Yang TH,Kim HM,Drake D,Liu XS,Bennett DA,Colaiácovo MP,Yankner BA</div> <div itemprop="description">MN1020 was used in western blot to investigate the role of repressor element 1-silencing transcription factor in neurodegeneration during ageing.</div> <div itemprodp="datePublished">Thu Mar 27 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24899140"> <div itemprop="name">Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">van der Zee J,Van Langenhove T,Kovacs GG,Dillen L,Deschamps W,Engelborghs S,Matěj R,Vandenbulcke M,Sieben A,Dermaut B,Smets K,Van Damme P,Merlin C,Laureys A,Van Den Broeck M,Mattheijssens M,Peeters K,Benussi L,Binetti G,Ghidoni R,Borroni B,Padovani A,Archetti S,Pastor P,Razquin C,Ortega-Cubero S,Hernández I,Boada M,Ruiz A,de Mendonça A,Miltenberger-Miltényi G,do Couto FS,Sorbi S,Nacmias B,Bagnoli S,Graff C,Chiang HH,Thonberg H,Perneczky R,Diehl-Schmid J,Alexopoulos P,Frisoni GB,Bonvicini C,Synofzik M,Maetzler W,vom Hagen JM,Schöls L,Haack TB,Strom TM,Prokisch H,Dols-Icardo O,Clarimón J,Lleó A,Santana I,Almeida MR,Santiago B,Heneka MT,Jessen F,Ramirez A,Sanchez-Valle R,Llado A,Gelpi E,Sarafov S,Tournev I,Jordanova A,Parobkova E,Fabrizi GM,Testi S,Salmon E,Ströbel T,Santens P,Robberecht W,De Jonghe P,Martin JJ,Cras P,Vandenberghe R,De Deyn PP,Cruts M,Sleegers K,Van Broeckhoven C</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to provide evidence for a putative role of rare mutations in Sequestosome 1 in the genetic etiology of frontotemporal lobar degeneration.</div> <div itemprodp="datePublished">Mon Sep 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25107476"> <div itemprop="name">Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Yarchoan M,Toledo JB,Lee EB,Arvanitakis Z,Kazi H,Han LY,Louneva N,Lee VM,Kim SF,Trojanowski JQ,Arnold SE</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to determine the expression of abnormal serine phosphorylation of insulin receptor substrate 1 in healthy and diseased human brains</div> <div itemprodp="datePublished">Sat Nov 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25085375"> <div itemprop="name">Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Collin L,Bohrmann B,Göpfert U,Oroszlan-Szovik K,Ozmen L,Grüninger F</div> <div itemprop="description">MN1020 was used in immunohistochemistry - free floating to investigate the mechanisms by which anti-Tau antibodies alleviate Alzheimer's disease in mice</div> <div itemprodp="datePublished">Wed Oct 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25069841"> <div itemprop="name">Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB.</div> </a> <div itemprop="about">EMBO molecular medicine</div> <div itemprop="author">Polito VA,Li H,Martini-Stoica H,Wang B,Yang L,Xu Y,Swartzlander DB,Palmieri M,di Ronza A,Lee VM,Sardiello M,Ballabio A,Zheng H</div> <div itemprop="description">MN1020 was used in immunocytochemistry and western blot to assess transcription factor ED activity in Alzheimer's disease mouse models</div> <div itemprodp="datePublished">Mon Sep 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24681487"> <div itemprop="name">Loss of the m-AAA protease subunit AFG₃L₂ causes mitochondrial transport defects and tau hyperphosphorylation.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">Kondadi AK,Wang S,Montagner S,Kladt N,Korwitz A,Martinelli P,Herholz D,Baker MJ,Schauss AC,Langer T,Rugarli EI</div> <div itemprop="description">MN1020 was used in immunohistochemistry and western blot to study the mitochondrial import defects and hyperphosphorylation of tau that result from depletion of the AFG(3)L(2) subunit of the m-AAA proteinase in neurons</div> <div itemprodp="datePublished">Fri May 02 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24421286"> <div itemprop="name">New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications.</div> </a> <div itemprop="about">Journal of neurology, neurosurgery, and psychiatry</div> <div itemprop="author">Chare L,Hodges JR,Leyton CE,McGinley C,Tan RH,Kril JJ,Halliday GM</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the clinical implications of new diagnostic criteria for frontotemporal dementia syndromes</div> <div itemprodp="datePublished">Fri Aug 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25042160"> <div itemprop="name">Tau reduction prevents disease in a mouse model of Dravet syndrome.</div> </a> <div itemprop="about">Annals of neurology</div> <div itemprop="author">Gheyara AL,Ponnusamy R,Djukic B,Craft RJ,Ho K,Guo W,Finucane MM,Sanchez PE,Mucke L</div> <div itemprop="description">MN1020 was used in immunohistochemistry to assess if tau reduction benefits intractable genetic epilepsies</div> <div itemprodp="datePublished">Mon Sep 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24341977"> <div itemprop="name">P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion.</div> </a> <div itemprop="about">Aging cell</div> <div itemprop="author">Pehar M,Ko MH,Li M,Scrable H,Puglielli L</div> <div itemprop="description">MN1020 was used in western blot to study the role of the short p44 isoform of p53 in driving the expression of tau-phosphorylating protein kinases and the age-dependent increase in nuclear p44</div> <div itemprodp="datePublished">Sun Jun 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24643416"> <div itemprop="name">Visualizing the microtubule-associated protein tau in the nucleus.</div> </a> <div itemprop="about">Science China. Life sciences</div> <div itemprop="author">Lu J,Li T,He R,Bartlett PF,Götz J</div> <div itemprop="description">MN1020 was used in western blot to perform a comparative study of methods for the detection of nuclear tau protein</div> <div itemprodp="datePublished">Tue Apr 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25073087"> <div itemprop="name">Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Aβ amyloidosis.</div> </a> <div itemprop="about">Neurobiology of disease</div> <div itemprop="author">Köhler C,Dinekov M,Götz J</div> <div itemprop="description">MN1020 was used in immunocytochemistry to assess the presence of granulovacuolar degeneration and the activated unfolded protein response in two mouse models of Alzheimer's disease</div> <div itemprodp="datePublished">Sat Nov 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24176788"> <div itemprop="name">Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.</div> </a> <div itemprop="about">Neurobiology of disease</div> <div itemprop="author">Baglietto-Vargas D,Kitazawa M,Le EJ,Estrada-Hernandez T,Rodriguez-Ortiz CJ,Medeiros R,Green KN,LaFerla FM</div> <div itemprop="description">MN1020 was used in western blot to study the effect of endogenous murine tau on cognition and neurofibrillary tangles in a murine Alzheimer's disease model transgenically expressing human tau</div> <div itemprodp="datePublished">Sat Feb 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24647946"> <div itemprop="name">Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Castillo-Carranza DL,Sengupta U,Guerrero-Muñoz MJ,Lasagna-Reeves CA,Gerson JE,Singh G,Estes DM,Barrett AD,Dineley KT,Jackson GR,Kayed R</div> <div itemprop="description">MN1020 was used in ELISA, immunohistochemistry, and western blot to study the ability of an anti-oligomeric tau monoclonal antibody to specifically reduce oligomeric tau and improve memory and locomotion in a murine Alzheimer's disease model</div> <div itemprodp="datePublished">Wed Mar 19 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25209291"> <div itemprop="name">Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Lee S,Xu G,Jay TR,Bhatta S,Kim KW,Jung S,Landreth GE,Ransohoff RM,Lamb BT</div> <div itemprop="description">MN1020 was used in immunohistochemistry - free floating and western blot to investigate the role of membrane-anchored versus soluble CX3CL1 in regulating the microglia-mediated amelioration of Abeta pathology</div> <div itemprodp="datePublished">Wed Sep 10 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25297091"> <div itemprop="name">Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Forny-Germano L,Lyra e Silva NM,Batista AF,Brito-Moreira J,Gralle M,Boehnke SE,Coe BC,Lablans A,Marques SA,Martinez AM,Klein WL,Houzel JC,Ferreira ST,Munoz DP,De Felice FG</div> <div itemprop="description">MN1020 was used in immunohistochemistry - free floating to study the impact of amyloid-beta oligomers in the brains of rats and adult cynomolgus macaques</div> <div itemprodp="datePublished">Wed Oct 08 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24828645"> <div itemprop="name">Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Shilling D,Müller M,Takano H,Mak DO,Abel T,Coulter DA,Foskett JK</div> <div itemprop="description">MN1020 was used in immunohistochemistry and western blot to study the role of exagerated Ca(2+) signaling mediated by InsP3 receptor1 in the pathogenesis of mutant presenilin-linked Alzheimer's disease</div> <div itemprodp="datePublished">Wed May 14 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24604080"> <div itemprop="name">Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease.</div> </a> <div itemprop="about">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</div> <div itemprop="author">Stancu IC,Ris L,Vasconcelos B,Marinangeli C,Goeminne L,Laporte V,Haylani LE,Couturier J,Schakman O,Gailly P,Pierrot N,Kienlen-Campard P,Octave JN,Dewachter I</div> <div itemprop="description">MN1020 was used in immunohistochemistry (free floating) to present data that suggests that pathological Aβ species induce changes in Tau that contribute to cognitive deficits correlating with synaptic deficits and hippocampal atrophy in an Alzheimer's disease model.</div> <div itemprodp="datePublished">Sun Jun 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24412516"> <div itemprop="name">Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Abbondante S,Baglietto-Vargas D,Rodriguez-Ortiz CJ,Estrada-Hernandez T,Medeiros R,Laferla FM</div> <div itemprop="description">MN1020 was used in western blot to study the cognitive defects observed in type 1 diabetes and the role of tau in mediating these effects</div> <div itemprodp="datePublished">Sat Mar 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24269557"> <div itemprop="name">α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Medeiros R,Castello NA,Cheng D,Kitazawa M,Baglietto-Vargas D,Green KN,Esbenshade TA,Bitner RS,Decker MW,LaFerla FM</div> <div itemprop="description">MN1020 was used in Western Blotting to determine the effect of long-term treatment with the selective α7 nAChR agonist A-582941 in aged 3xTg-AD mice with robust Alzheimer's disease-like pathology.</div> <div itemprodp="datePublished">Sat Feb 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25309427"> <div itemprop="name">Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice.</div> </a> <div itemprop="about">Frontiers in aging neuroscience</div> <div itemprop="author">Castro-Alvarez JF,Uribe-Arias SA,Kosik KS,Cardona-Gómez GP</div> <div itemprop="description">MN1020 was used in western blot to use triple transgenic Alzhemier's mice to study short- and long-term CDK5 knockdown and prevention of spatial memory dysfunction and tau pathology</div> <div itemprodp="datePublished">Mon Oct 13 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24389273"> <div itemprop="name">Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.</div> </a> <div itemprop="about">Experimental neurology</div> <div itemprop="author">Yamada ES,Respondek G,Müssner S,de Andrade A,Höllerhage M,Depienne C,Rastetter A,Tarze A,Friguet B,Salama M,Champy P,Oertel WH,Höglinger GU</div> <div itemprop="description">MN1020 was used in immunohistochemistry and western blot to study the increased tau phosphorylation following treatment with a mitochondrial complex I inhibitor in a tau transgenic mouse model</div> <div itemprodp="datePublished">Sat Mar 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23895348"> <div itemprop="name">Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance.</div> </a> <div itemprop="about">Journal of neurochemistry</div> <div itemprop="author">Bonda DJ,Stone JG,Torres SL,Siedlak SL,Perry G,Kryscio R,Jicha G,Casadesus G,Smith MA,Zhu X,Lee HG</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the involvement of neuronal leptin resistance in Alzheimer's disease</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24601954"> <div itemprop="name">Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice.</div> </a> <div itemprop="about">Journal of neurochemistry</div> <div itemprop="author">Palm R,Chang J,Blair J,Garcia-Mesa Y,Lee HG,Castellani RJ,Smith MA,Zhu X,Casadesus G</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the improvement in neuronal plasticity and cognition in ovariectomized Alzheimer's disease mice following serum gonadotropin down regulation</div> <div itemprodp="datePublished">Tue Jul 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24326295"> <div itemprop="name">Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.</div> </a> <div itemprop="about">Neuropharmacology</div> <div itemprop="author">Graham DL,Gray AJ,Joyce JA,Yu D,O'Moore J,Carlson GA,Shearman MS,Dellovade TL,Hering H</div> <div itemprop="description">MN1020 was used in immunohistochemistry and western blot to study the mechanism by which O-GlcNAcylation prevents pathological agregation of tau in a murine tauopathy model</div> <div itemprodp="datePublished">Tue Apr 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24880087"> <div itemprop="name">Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance.</div> </a> <div itemprop="about">Neuropharmacology</div> <div itemprop="author">Jiang T,Yu JT,Zhu XC,Zhang QQ,Cao L,Wang HF,Tan MS,Gao Q,Qin H,Zhang YD,Tan L</div> <div itemprop="description">MN1020 was used in immunohistochemistry and western blot to study the ability of the rapamycin analog temsirolimus to promote autophagic clearance of hyperphosphorylated tau and improve memory deficits in animal models</div> <div itemprodp="datePublished">Wed Oct 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24332448"> <div itemprop="name">Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Huang XT,Qian ZM,He X,Gong Q,Wu KC,Jiang LR,Lu LN,Zhu ZJ,Zhang HY,Yung WH,Ke Y</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the role of reduced brain iron levels in the neuroprotective effects of huperzine A in a murine model of Alzheimer's disease</div> <div itemprodp="datePublished">Thu May 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24411482"> <div itemprop="name">Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Orr ME,Salinas A,Buffenstein R,Oddo S</div> <div itemprop="description">MN1020 was used in western blot to study the role of mTOR hyperactivation in the mechanism by which a high-sucrose diet promotes beta-amyloid pathology in Alzheimer's disease</div> <div itemprodp="datePublished">Sun Jun 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24845186"> <div itemprop="name">Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms.</div> </a> <div itemprop="about">Psychoneuroendocrinology</div> <div itemprop="author">García-Mesa Y,Pareja-Galeano H,Bonet-Costa V,Revilla S,Gómez-Cabrera MC,Gambini J,Giménez-Llort L,Cristòfol R,Viña J,Sanfeliu C</div> <div itemprop="description">MN1020 was used in western blot to study the role of BDNF in the neuropretoective effects of aerobic physical exercise in a murine model of Alzheimer's disease</div> <div itemprodp="datePublished">Tue Jul 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24679899"> <div itemprop="name">Alzheimer's-related changes in non-demented essential tremor patients vs. controls: links between tau and tremor?</div> </a> <div itemprop="about">Parkinsonism & related disorders</div> <div itemprop="author">Pan JJ,Lee M,Honig LS,Vonsattel JP,Faust PL,Louis ED</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the relationships between essential tremor, tau pathology and Alzheimer's disease</div> <div itemprodp="datePublished">Sun Jun 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24448785"> <div itemprop="name">Altered function of hippocampal CA1 pyramidal neurons in the rTg4510 mouse model of tauopathy.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Dalby NO,Volbracht C,Helboe L,Larsen PH,Jensen HS,Egebjerg J,Elvang AB</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study hippocampal CA1 pyramidal neuron function in a murine tauopathy model</div> <div itemprodp="datePublished">Thu Jan 15 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24787918"> <div itemprop="name">Region-specific expression of tau, amyloid-β protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Lin L,Yang SS,Chu J,Wang L,Ning LN,Zhang T,Jiang Q,Tian Q,Wang JZ</div> <div itemprop="description">MN1020 was used in western blot to study the regional expression of proteins involved in Alzheimer's disease pathology and the effect of indicung ER stress</div> <div itemprodp="datePublished">Mon Mar 30 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24270207"> <div itemprop="name">Hyperphosphorylated tau is elevated in Alzheimer's disease with psychosis.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Murray PS,Kirkwood CM,Gray MC,Fish KN,Ikonomovic MD,Hamilton RL,Kofler JK,Klunk WE,Lopez OL,Sweet RA</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the relationship between Alzheimer's disease displaying psychosis and tau hyperphosphorylation</div> <div itemprodp="datePublished">Thu Oct 30 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24246421"> <div itemprop="name">Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Yanagisawa D,Taguchi H,Ibrahim NF,Morikawa S,Shiino A,Inubushi T,Hirao K,Shirai N,Sogabe T,Tooyama I</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the probe structural requirements for [19F] MRI detection of brain amyloid</div> <div itemprodp="datePublished">Mon Oct 06 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24121962"> <div itemprop="name">Distribution of pathology in frontal variant Alzheimer's disease.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Blennerhassett R,Lillo P,Halliday GM,Hodges JR,Kril JJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the spacial distribution of neurodegeneration in the brains of patients with frontal variant Alzheimer's disease</div> <div itemprodp="datePublished">Wed Sep 03 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24768523"> <div itemprop="name">Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis.</div> </a> <div itemprop="about">FEBS letters</div> <div itemprop="author">Inoue H,Hiradate Y,Shirakata Y,Kanai K,Kosaka K,Gotoh A,Fukuda Y,Nakai Y,Uchida T,Sato E,Tanemura K</div> <div itemprop="description">MN1020 was used in immunohistochemistry and western blot to study the role of Tau phosphorylation in murine spermatogenesis during meiosis</div> <div itemprodp="datePublished">Thu May 29 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24709683"> <div itemprop="name">A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Bit-Ivan EN,Suh E,Shim HS,Weintraub S,Hyman BT,Arnold SE,McCarty-Wood E,Van Deerlin VM,Schneider JA,Trojanowski JQ,Frosch MP,Baker MC,Rademakers R,Mesulam M,Bigio EH</div> <div itemprop="description">MN1020 was used in immunohistochemistry to report on six cases of frontotemporal lobar degeneration with TDP-43-positive inclusions bearing a novel GRN mutation</div> <div itemprodp="datePublished">Thu May 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24387791"> <div itemprop="name">Distribution of the hematopoietic growth factor G-CSF and its receptor in the adult human brain with specific reference to Alzheimer's disease.</div> </a> <div itemprop="about">Journal of anatomy</div> <div itemprop="author">Ridwan S,Bauer H,Frauenknecht K,Hefti K,von Pein H,Sommer CJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the protein expression of G-CSF and its receptor in the adult human brain</div> <div itemprodp="datePublished">Tue Apr 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24354628"> <div itemprop="name">Neuropathologic analysis of hematomas evacuated from patients with spontaneous intracerebral hemorrhage.</div> </a> <div itemprop="about">Neuropathology : official journal of the Japanese Society of Neuropathology</div> <div itemprop="author">Dye JA,Rees G,Yang I,Vespa PM,Martin NA,Vinters HV</div> <div itemprop="description">MN1020 was used in immunohistochemistry to perform a detailed analysis of hematomas resected from patients suffering spontaneous intracerebral hemorrhage</div> <div itemprodp="datePublished">Sun Jun 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23869942"> <div itemprop="name">Immunohistochemical analysis of ubiquilin-1 in the human hippocampus: association with neurofibrillary tangle pathology.</div> </a> <div itemprop="about">Neuropathology : official journal of the Japanese Society of Neuropathology</div> <div itemprop="author">Mizukami K,Abrahamson EE,Mi Z,Ishikawa M,Watanabe K,Kinoshita S,Asada T,Ikonomovic MD</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the relationship between human hippocampal ubiquilin-1 and neurofibrilliary tangles in Alzheimer's disease brain</div> <div itemprodp="datePublished">Sat Feb 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24444358"> <div itemprop="name">Two cases of multinodular and vacuolating neuronal tumour.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Bodi I,Curran O,Selway R,Elwes R,Burrone J,Laxton R,Al-Sarraj S,Honavar M</div> <div itemprop="description">MN1020 was used in immunohistochemistry (paraffin) to characterize two patients with multinodular and vacuolating neuronal tumors.</div> <div itemprodp="datePublished">Mon Jan 20 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24374316"> <div itemprop="name">Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease.</div> </a> <div itemprop="about">Biochimica et biophysica acta</div> <div itemprop="author">Torres M,Price SL,Fiol-Deroque MA,Marcilla-Etxenike A,Ahyayauch H,Barceló-Coblijn G,Terés S,Katsouri L,Ordinas M,López DJ,Ibarguren M,Goñi FM,Busquets X,Vitorica J,Sastre M,Escribá PV</div> <div itemprop="description">MN1020 was used in western blot to study the role of changes in membrane lipid composition in the therapeutic effects of 2-hydroxydocosahexaenoic acid in a murine model of Alzheimer's disease</div> <div itemprodp="datePublished">Sun Jun 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25432085"> <div itemprop="name">Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice.</div> </a> <div itemprop="about">Molecular neurodegeneration</div> <div itemprop="author">Ohia-Nwoko O,Montazari S,Lau YS,Eriksen JL</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section and western blot to evaluate motor function and tau pathology of P301S tau transgenic mice</div> <div itemprodp="datePublished">Fri Nov 28 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24887264"> <div itemprop="name">The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Lasagna-Reeves CA,Sengupta U,Castillo-Carranza D,Gerson JE,Guerrero-Munoz M,Troncoso JC,Jackson GR,Kayed R</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the formation of tau annular protofibrils and the significance for different neurodegenerative tauopathic diseases</div> <div itemprodp="datePublished">Thu May 29 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24479894"> <div itemprop="name">Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Dujardin S,Lécolle K,Caillierez R,Bégard S,Zommer N,Lachaud C,Carrier S,Dufour N,Aurégan G,Winderickx J,Hantraye P,Déglon N,Colin M,Buée L</div> <div itemprop="description">MN1020 was used in immunohistochemistry to discuss the molecular and cellular mechanisms that contribute to disease progression in sporadic tauopathies such as argyrophilic grain disorder and progressive supranuclear palsy</div> <div itemprodp="datePublished">Thu Jan 30 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24586443"> <div itemprop="name">S100A9 knockout decreases the memory impairment and neuropathology in crossbreed mice of Tg2576 and S100A9 knockout mice model.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Kim HJ,Chang KA,Ha TY,Kim J,Ha S,Shin KY,Moon C,Nacken W,Kim HS,Suh YH</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the beneficial effects of S100A9 deletion on memory and beta-amyloid pathology in a murine model of Alzheimer's disease</div> <div itemprodp="datePublished">Mon Dec 22 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26344748"> <div itemprop="name">Doubly Phosphorylated Peptide Vaccines to Protect Transgenic P301S Mice against Alzheimer's Disease Like Tau Aggregation.</div> </a> <div itemprop="about">Vaccines</div> <div itemprop="author">Richter M,Mewes A,Fritsch M,Krügel U,Hoffmann R,Singer D</div> <div itemprop="description">MN1020 was used in immunohistochemistry and western blot to study protection of transgenic P301S mice against tau aggregation in Alzheimer's disease by doubly phosphorylated peptied vaccines</div> <div itemprodp="datePublished">Tue Jul 29 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25422066"> <div itemprop="name">The problem of axonal injury in the brains of veterans with histories of blast exposure.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Ryu J,Horkayne-Szakaly I,Xu L,Pletnikova O,Leri F,Eberhart C,Troncoso JC,Koliatsos VE</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to characterize the neuropathology of blast injury</div> <div itemprodp="datePublished">Tue Nov 25 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24132763"> <div itemprop="name">Brainstem aminergic nuclei and late-life depressive symptoms.</div> </a> <div itemprop="about">JAMA psychiatry</div> <div itemprop="author">Wilson RS,Nag S,Boyle PA,Hizel LP,Yu L,Buchman AS,Shah RC,Schneider JA,Arnold SE,Bennett DA</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the neurobiologic basis of late-life depressive symptoms</div> <div itemprodp="datePublished">Sun Dec 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23494099"> <div itemprop="name">Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Wu TH,Lu YN,Chuang CL,Wu CL,Chiang AS,Krantz DE,Chang HY</div> <div itemprop="description">MN1020 was used in immunocytochemistry to report that expression of human wild-type tau is sufficient to disrupt the survival of dopaminergic neurons in a Drosophila model</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23666556"> <div itemprop="name">Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Clippinger AK,D'Alton S,Lin WL,Gendron TF,Howard J,Borchelt DR,Cannon A,Carlomagno Y,Chakrabarty P,Cook C,Golde TE,Levites Y,Ranum L,Schultheis PJ,Xu G,Petrucelli L,Sahara N,Dickson DW,Giasson B,Lewis J</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to test if a primary proteinopathy might secondarily drive TDP-43 proteinopathy</div> <div itemprodp="datePublished">Mon Jul 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23771339"> <div itemprop="name">Parkinson's disease is associated with altered expression of CaV1 channels and calcium-binding proteins.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Hurley MJ,Brandon B,Gentleman SM,Dexter DT</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to examine the expression of Ca(V)1 subtypes and various Calcium-binding proteins in areas vulnerable and resistant to neurodegeneration in Parkinson's disease.</div> <div itemprodp="datePublished">Mon Jul 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23609018"> <div itemprop="name">Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain.</div> </a> <div itemprop="about">Molecular therapy : the journal of the American Society of Gene Therapy</div> <div itemprop="author">Caillierez R,Bégard S,Lécolle K,Deramecourt V,Zommer N,Dujardin S,Loyens A,Dufour N,Aurégan G,Winderickx J,Hantraye P,Déglon N,Buée L,Colin M</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the slow and progressive neurodegeneration induced in rat brain by lentiviral-mediated transduction with wild-type human tau</div> <div itemprodp="datePublished">Mon Jul 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23312564"> <div itemprop="name">Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.</div> </a> <div itemprop="about">Biological psychiatry</div> <div itemprop="author">Baglietto-Vargas D,Medeiros R,Martinez-Coria H,LaFerla FM,Green KN</div> <div itemprop="description">MN1020 was used in western blot to study the reduced alpha- and beta-cleavage of APP and reduced phosporylated tau accumulation in transgenic mice treated with mifepristone</div> <div itemprodp="datePublished">Sun Sep 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23922306"> <div itemprop="name">Clinical correlates in an experimental model of repetitive mild brain injury.</div> </a> <div itemprop="about">Annals of neurology</div> <div itemprop="author">Mannix R,Meehan WP,Mandeville J,Grant PE,Gray T,Berglass J,Zhang J,Bryant J,Rezaie S,Chung JY,Peters NV,Lee C,Tien LW,Kaplan DL,Feany M,Whalen M</div> <div itemprop="description">MN1020 was used in immunohistochemistry to use a murine model of repetetive mild brain injury to study whether the observed congnitive deficits are associated with beta-amyloid/tau pathology or ApoE allele</div> <div itemprodp="datePublished">Mon Jul 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23362919"> <div itemprop="name">Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model.</div> </a> <div itemprop="about">Aging cell</div> <div itemprop="author">Parrella E,Maxim T,Maialetti F,Zhang L,Wan J,Wei M,Cohen P,Fontana L,Longo VD</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the effect of periodic protein restriction cycles on levels of IGF-1, phosphorylated tau, and cognitive performance in a murine model of Alzheimer's disease</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23250356"> <div itemprop="name">Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice.</div> </a> <div itemprop="about">Diabetes</div> <div itemprop="author">Leboucher A,Laurent C,Fernandez-Gomez FJ,Burnouf S,Troquier L,Eddarkaoui S,Demeyer D,Caillierez R,Zommer N,Vallez E,Bantubungi K,Breton C,Pigny P,Buée-Scherrer V,Staels B,Hamdane M,Tailleux A,Buée L,Blum D</div> <div itemprop="description">MN1020 was used in immunohistochemistry - free floating to study the effects of diet-induced obesity on tau pathology</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23493042"> <div itemprop="name">Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology</div> <div itemprop="author">Lahmy V,Meunier J,Malmström S,Naert G,Givalois L,Kim SH,Villard V,Vamvakides A,Maurice T</div> <div itemprop="description">MN1020 was used in Western Blotting to establish whether the mixed σ1/muscarinic ligand ANAVEX2-73 could have the ability to reduce the appearance of hyperphosphorylated Tau and amyloid-β1-42.</div> <div itemprodp="datePublished">Thu Aug 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23678130"> <div itemprop="name">Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Barron AM,Garcia-Segura LM,Caruso D,Jayaraman A,Lee JW,Melcangi RC,Pike CJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the ability of the Ro5-4864 translocator protein ligand to protect against disease pathology and behaviour deficit in a murine model of Alzheimer's disease</div> <div itemprodp="datePublished">Wed May 15 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23283346"> <div itemprop="name">Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Sundaram JR,Poore CP,Sulaimee NH,Pareek T,Asad AB,Rajkumar R,Cheong WF,Wenk MR,Dawe GS,Chuang KH,Pant HC,Kesavapany S</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to study the effects of selective inhibition of p25/Cdk5 hyperactivation in vivo on neurodegenerative pathologies.</div> <div itemprodp="datePublished">Wed Jan 02 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23283346"> <div itemprop="name">Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Sundaram JR,Poore CP,Sulaimee NH,Pareek T,Asad AB,Rajkumar R,Cheong WF,Wenk MR,Dawe GS,Chuang KH,Pant HC,Kesavapany S</div> <div itemprop="description">MN1020 was used in Immunohistochemistry-immunofluorescence to study the effects of selective inhibition of p25/Cdk5 hyperactivation in vivo on neurodegenerative pathologies.</div> <div itemprodp="datePublished">Wed Jan 02 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22995388"> <div itemprop="name">Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">The Journal of nutritional biochemistry</div> <div itemprop="author">Vepsäläinen S,Koivisto H,Pekkarinen E,Mäkinen P,Dobson G,McDougall GJ,Stewart D,Haapasalo A,Karjalainen RO,Tanila H,Hiltunen M</div> <div itemprop="description">MN1020 was used in western blot to study the beneficial effects of anthacyanin-rich bilberry and blackberry extracts on APP processing and behavioural deficits in a murine model of Alzheimer's disease</div> <div itemprodp="datePublished">Tue Jan 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23805846"> <div itemprop="name">Alzheimer's amyloid-β oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway.</div> </a> <div itemprop="about">ACS chemical neuroscience</div> <div itemprop="author">Chen RJ,Chang WW,Lin YC,Cheng PL,Chen YR</div> <div itemprop="description">MN1020 was used in western blot to study the role of the Fyn pathway in the mechanism by which beta-amyloid oligomers modulate the down regulation of tau by cellular prion protein</div> <div itemprodp="datePublished">Wed Sep 18 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23527608"> <div itemprop="name">Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology.</div> </a> <div itemprop="about">ACS chemical neuroscience</div> <div itemprop="author">Alonso E,Vale C,Vieytes MR,Botana LM</div> <div itemprop="description">MN1020 was used in western blot to study the role of PKC activation in the mechanism underyling the beneficial effects of yessotoxin on tau and Abeta pathology in a cellular model of Alzheimer's disease</div> <div itemprodp="datePublished">Wed Jul 17 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23451743"> <div itemprop="name">Making the diagnosis of frontotemporal lobar degeneration.</div> </a> <div itemprop="about">Archives of pathology & laboratory medicine</div> <div itemprop="author">Bigio EH</div> <div itemprop="description">MN1020 was used in immunohistochemistry to review the diagnosis of frontotemporal lobar degeneration</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23528227"> <div itemprop="name">Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Geekiyanage H,Upadhye A,Chan C</div> <div itemprop="description">MN1020 was used in western blot to study the reduction in beta-amyloid levels and tau hyperphosphorylation in response to inhibition of serine palmitoyltransferase in a mouse model of Alzheimer's disease</div> <div itemprodp="datePublished">Thu Aug 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22819391"> <div itemprop="name">MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Colom-Cadena M,Gelpi E,Martí MJ,Charif S,Dols-Icardo O,Blesa R,Clarimón J,Lleó A</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the relationship between MAPT haplotype and enhanced alpha-synuclein deposition in dementia with Lewy bodies</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22592019"> <div itemprop="name">p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Cancino GI,Miller FD,Kaplan DR</div> <div itemprop="description">MN1020 was used in western blot to study the effects of p73 haploinsufficiency on tau phosphorylation status and the activity of GSK3-beta, c-Abl and Cdk5 in murine models of ageing and Alzheimer's disease</div> <div itemprodp="datePublished">Fri Feb 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23332170"> <div itemprop="name">Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Nash KR,Lee DC,Hunt JB,Morganti JM,Selenica ML,Moran P,Reid P,Brownlow M,Guang-Yu Yang C,Savalia M,Gemma C,Bickford PC,Gordon MN,Morgan D</div> <div itemprop="description">MN1020 was used in western blot to study the beneficial effects on tau pathology in a murine transgenic tauopathy model of the virally-mediated overexpression of soluble fractalkine</div> <div itemprodp="datePublished">Sat Jun 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23294633"> <div itemprop="name">Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Köhler C,Dinekov M,Götz J</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the association of GSK3 activity with tau phosphorylation and neuronal tyrosine phosphorylation in a murine model expressing human P301L tau</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22503003"> <div itemprop="name">Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Braak H,Thal DR,Matschke J,Ghebremedhin E,Del Tredici K</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the presence of dendritic inclusions in catecholaminergic brainstem neurons and their increased prevalence with advancing age</div> <div itemprodp="datePublished">Tue Jan 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22892312"> <div itemprop="name">PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Magnaudeix A,Wilson CM,Page G,Bauvy C,Codogno P,Lévêque P,Labrousse F,Corre-Delage M,Yardin C,Terro F</div> <div itemprop="description">MN1020 was used in western blot to study the effect of protein phosphatase 2A modulation on neuronal autophagy.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23121727"> <div itemprop="name">Dopamine D2 receptor SPECT in corticobasal syndrome and autopsy-confirmed corticobasal degeneration.</div> </a> <div itemprop="about">Parkinsonism & related disorders</div> <div itemprop="author">Pirker S,Perju-Dumbrava L,Kovacs GG,Traub-Weidinger T,Asenbaum S,Pirker W</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study striatal dopamine D2 receptor binding in corticobasal syndrome</div> <div itemprodp="datePublished">Fri Feb 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22986780"> <div itemprop="name">SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Capsoni S,Carlo AS,Vignone D,Amato G,Criscuolo C,Willnow TE,Cattaneo A</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the effect of SorLA-deficiency to dissociate amyloid and tau neurodegeneration in a novel murine model of Alzheimer's disease</div> <div itemprodp="datePublished">Tue May 28 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23594602"> <div itemprop="name">Abnormal interaction of oligomeric amyloid-β with phosphorylated tau: implications to synaptic dysfunction and neuronal damage.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Manczak M,Reddy PH</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the interaction of monomeric and oligomeric beta-amyloid with phosphorylated tau in the brains of Alzheimer's disease patients</div> <div itemprodp="datePublished">Mon Jan 27 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23948907"> <div itemprop="name">Distribution of SLC10A4, a synaptic vesicle protein in the human brain, and the association of this protein with Alzheimer's disease-related neuronal degeneration.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Popova SN,Alafuzoff I</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the distribution in human brain of the synaptic protein SLC10A4 and its potential association with Alzheimer's disease neurodegeneration</div> <div itemprodp="datePublished">Fri Jun 27 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23948940"> <div itemprop="name">Of rodents and men: the mysterious interneuronal pilgrimage of misfolded protein tau in Alzheimer’s disease.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Levarska L,Zilka N,Jadhav S,Neradil P,Novak M</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the infectivity and spreading propensity of tau complexes containing the 3R or 4R human tau misfolded truncates</div> <div itemprodp="datePublished">Fri Jun 27 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23970038"> <div itemprop="name">Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Natunen T,Parrado AR,Helisalmi S,Pursiheimo JP,Sarajärvi T,Mäkinen P,Kurkinen KM,Mullin K,Alafuzoff I,Haapasalo A,Bertram L,Soininen H,Tanzi RE,Hiltunen M</div> <div itemprop="description">MN1020 was used in western blot to study whether the BACE1-modulator GGA3 contributes to Alzheimer's disease pathology</div> <div itemprodp="datePublished">Tue Apr 08 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23396115"> <div itemprop="name">Maladaptive exploratory behavior and neuropathology of the PS-1 P117L Alzheimer transgenic mice.</div> </a> <div itemprop="about">Brain research bulletin</div> <div itemprop="author">Zufferey V,Vallet PG,Moeri M,Moulin-Sallanon M,Piotton F,Marin P,Savioz A</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the neuropatholgy and behavioural abnormalities of a murine Alzheimer's disease model transgenically expressing P117L mutant presenilin-1</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23261664"> <div itemprop="name">Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice.</div> </a> <div itemprop="about">Brain research</div> <div itemprop="author">Morcinek K,Köhler C,Götz J,Schröder H</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study whether the expression of mutant human tau in tau filament-forming mice recapitulates the pathological chages observed in Alzheimer's disease brainstem</div> <div itemprodp="datePublished">Mon Feb 25 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23592568"> <div itemprop="name">Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium.</div> </a> <div itemprop="about">ChemMedChem</div> <div itemprop="author">Gu J,Anumala UR,Heyny-von Haußen R,Hölzer J,Goetschy-Meyer V,Mall G,Hilger I,Czech C,Schmidt B</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the use of fluorescent trimethine cyanine dyes for the detection of tau fibrils in postmortem Alzheimer's disease brain</div> <div itemprodp="datePublished">Sat Jun 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23859773"> <div itemprop="name">Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains.</div> </a> <div itemprop="about">Bioorganic & medicinal chemistry</div> <div itemprop="author">Anumala UR,Gu J,Lo Monte F,Kramer T,Heyny-von Haußen R,Hölzer J,Goetschy-Meyer V,Schön C,Mall G,Hilger I,Czech C,Herms J,Schmidt B</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the detection of neurofibrilliary tangles in Alzheimer's disease brains using fluorescent rhodamine-3-acetic acid-based imaging probes</div> <div itemprodp="datePublished">Sun Sep 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22797329"> <div itemprop="name">Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.</div> </a> <div itemprop="about">Neuro-degenerative diseases</div> <div itemprop="author">Flunkert S,Hierzer M,Löffler T,Rabl R,Neddens J,Duller S,Schofield EL,Ward MA,Posch M,Jungwirth H,Windisch M,Hutter-Paier B</div> <div itemprop="description">MN1020 was used in western blot to study the role of soluble total and hyperphosphorylated tau in brain pathology and behaviour in a transgenic mouse model</div> <div itemprodp="datePublished">Wed Nov 13 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24042198"> <div itemprop="name">A derivative of the brain metabolite lanthionine ketimine improves cognition and diminishes pathology in the 3 × Tg-AD mouse model of Alzheimer disease.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Hensley K,Gabbita SP,Venkova K,Hristov A,Johnson MF,Eslami P,Harris-White ME</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the beneficial effects of a bioavailable ester of lanthione ketimine in respect of cognition and pathology in a murine model of Alzheimer's disease</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24128675"> <div itemprop="name">Abnormal gephyrin immunoreactivity associated with Alzheimer disease pathologic changes.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Hales CM,Rees H,Seyfried NT,Dammer EB,Duong DM,Gearing M,Montine TJ,Troncoso JC,Thambisetty M,Levey AI,Lah JJ,Wingo TS</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the role of gephyrin accumulation in the pathology of Alzheimer's disease</div> <div itemprodp="datePublished">Fri Nov 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23881733"> <div itemprop="name">Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla).</div> </a> <div itemprop="about">The Journal of comparative neurology</div> <div itemprop="author">Perez SE,Raghanti MA,Hof PR,Kramer L,Ikonomovic MD,Lacor PN,Erwin JM,Sherwood CC,Mufson EJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the pathology of Alzheimer's disease in the western lowland Gorilla</div> <div itemprodp="datePublished">Sun Dec 15 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23537935"> <div itemprop="name">Paraffin sections of 70-100 μm: a novel technique and its benefits for studying the nervous system.</div> </a> <div itemprop="about">Journal of neuroscience methods</div> <div itemprop="author">Feldengut S,Del Tredici K,Braak H</div> <div itemprop="description">MN1020 was used in immunohistochemistry to report on the use of 70-100 micrometer paraffin sections for studying the nervous system</div> <div itemprodp="datePublished">Wed May 15 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23541297"> <div itemprop="name">Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia.</div> </a> <div itemprop="about">Brain and language</div> <div itemprop="author">Josephs KA,Dickson DW,Murray ME,Senjem ML,Parisi JE,Petersen RC,Jack CR,Whitwell JL</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study grey matter volume and neurofibrilliary tangle density in Alzheimer's disease patients including those presenting with logopenic progressive aphasia</div> <div itemprodp="datePublished">Fri Nov 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23844236"> <div itemprop="name">The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Rantamäki T,Kemppainen S,Autio H,Stavén S,Koivisto H,Kojima M,Antila H,Miettinen PO,Kärkkäinen E,Karpova N,Vesa L,Lindemann L,Hoener MC,Tanila H,Castrén E</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the effects of Bdnf gene deficiency on memory, behaviour and disease pathology in a murine Alzheimer's disease model</div> <div itemprodp="datePublished">Fri Feb 07 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24086754"> <div itemprop="name">Ubiquilin 2 is not associated with tau pathology.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Nölle A,van Haastert ES,Zwart R,Hoozemans JJ,Scheper W</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the lack of association of ubiquilin-2 with tau pathology in Alzheimer's disease</div> <div itemprodp="datePublished">Mon Jun 16 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22127507"> <div itemprop="name">Age-related loss of noradrenergic neurons in the brains of triple transgenic mice.</div> </a> <div itemprop="about">Age (Dordrecht, Netherlands)</div> <div itemprop="author">Manaye KF,Mouton PR,Xu G,Drew A,Lei DL,Sharma Y,Rebeck GW,Turner S</div> <div itemprop="description">MN1020 was used in immunocytochemistry to investigate the changes of TH+ neurons in an Alzheimer disease mouse model</div> <div itemprodp="datePublished">Fri Feb 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23632019"> <div itemprop="name">Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Hawkins BE,Krishnamurthy S,Castillo-Carranza DL,Sengupta U,Prough DS,Jackson GR,DeWitt DS,Kayed R</div> <div itemprop="description">MN1020 was used in ELISA, immunohistochemistry, and western blot to study the generation of oligomeric and phosphorylated forms of tau in a rat model of traumatic brain injury</div> <div itemprodp="datePublished">Fri Jun 07 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24344647"> <div itemprop="name">Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Hoffmann NA,Dorostkar MM,Blumenstock S,Goedert M,Herms J</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the potential involvement of pre-fibrilliary tau in the defective plasticity of cortical dendritic spines observed in transgenic mice bearing the P301S tau mutation</div> <div itemprodp="datePublished">Tue Dec 17 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23667480"> <div itemprop="name">Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Ozcelik S,Fraser G,Castets P,Schaeffer V,Skachokova Z,Breu K,Clavaguera F,Sinnreich M,Kappos L,Goedert M,Tolnay M,Winkler DT</div> <div itemprop="description">MN1020 was used in immunohistochemistry and western blot to study the protective effects of rapamycin against tau pathology in a murine transgenic model</div> <div itemprodp="datePublished">Mon Dec 09 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24252759"> <div itemprop="name">In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Trujillo-Estrada L,Jimenez S,De Castro V,Torres M,Baglietto-Vargas D,Moreno-Gonzalez I,Navarro V,Sanchez-Varo R,Sanchez-Mejias E,Davila JC,Vizuete M,Gutierrez A,Vitorica J</div> <div itemprop="description">MN1020 was used in western blot to study the beneficial effects of lithium treatment on beta-amyloid neuropathology in a murine model of Alzheimer's disease</div> <div itemprodp="datePublished">Tue Nov 12 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24278223"> <div itemprop="name">Specific serotonergic denervation affects tau pathology and cognition without altering senile plaques deposition in APP/PS1 mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Ramos-Rodriguez JJ,Molina-Gil S,Rey-Brea R,Berrocoso E,Garcia-Alloza M</div> <div itemprop="description">MN1020 was used in Western Blotting to study the role of serotonergic denervation in some of the pathological aspects observed in Alzheimer's disease.</div> <div itemprodp="datePublished">Tue Sep 23 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23521156"> <div itemprop="name">Clusterin associates specifically with Aβ40 in Alzheimer's disease brain tissue.</div> </a> <div itemprop="about">Brain pathology (Zurich, Switzerland)</div> <div itemprop="author">Howlett DR,Hortobágyi T,Francis PT</div> <div itemprop="description">MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that in AD, but not aged control brain, clusterin was associated specifically with the Aβ40 form of Aβ in the brain.</div> <div itemprodp="datePublished">Fri Nov 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23618906"> <div itemprop="name">NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Tackenberg C,Grinschgl S,Trutzel A,Santuccione AC,Frey MC,Konietzko U,Grimm J,Brandt R,Nitsch RM</div> <div itemprop="description">MN1020 was used in western blot to study the effect of the subunit composition of NMDA receptors on neurodegeneration and synaptic loss induced by beta-amyloid</div> <div itemprodp="datePublished">Thu Apr 25 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23554879"> <div itemprop="name">PINCH in the cellular stress response to tau-hyperphosphorylation.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Ozdemir AY,Rom I,Kovalevich J,Yen W,Adiga R,Dave RS,Langford D</div> <div itemprop="description">MN1020 was used in western blot to study the ability of PINCH in bind and stabilize hyperphoshorylated tau</div> <div itemprodp="datePublished">Mon Sep 30 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23415811"> <div itemprop="name">Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate.</div> </a> <div itemprop="about">Biochimica et biophysica acta</div> <div itemprop="author">Barros-Miñones L,Martín-de-Saavedra D,Perez-Alvarez S,Orejana L,Suquía V,Goñi-Allo B,Hervias I,López MG,Jordan J,Aguirre N,Puerta E</div> <div itemprop="description">MN1020 was used in western blot to study the role of calpain-regulated p35/cdk5 in the mechanism by which the PDE5 inhibitor sildenafil protects against malonate-induced chemical hypoxia</div> <div itemprodp="datePublished">Sat Jun 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22476197"> <div itemprop="name">Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Talbot K,Wang HY,Kazi H,Han LY,Bakshi KP,Stucky A,Fuino RL,Kawaguchi KR,Samoyedny AJ,Wilson RS,Arvanitakis Z,Schneider JA,Wolf BA,Bennett DA,Trojanowski JQ,Arnold SE</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the role of IGF-1 and IRS-1 in brain insulin resistance and cognitive decline in Alzheimer's disease</div> <div itemprodp="datePublished">Sun Apr 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23209315"> <div itemprop="name">Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Yao J,Ho D,Calingasan NY,Pipalia NH,Lin MT,Beal MF</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the beneficial effects of hydroxy-beta-cyclodextrin on neuropathology and beta-amyloid levels in Alzheimer's disease models</div> <div itemprodp="datePublished">Mon Dec 17 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22222584"> <div itemprop="name">Asymmetry of neurodegenerative disease-related pathologies: a cautionary note.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Stefanits H,Budka H,Kovacs GG</div> <div itemprop="description">MN1020 was used in immunohistochemistry to characterize Alzheimer disease associated pathology</div> <div itemprodp="datePublished">Thu Mar 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22160320"> <div itemprop="name">Hyperphosphorylated tau in young and middle-aged subjects.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Elobeid A,Soininen H,Alafuzoff I</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to examine the brains of cognitively unimpaired subjects for neurodegenerative changes</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22170742"> <div itemprop="name">Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Okamoto Y,Yamamoto T,Kalaria RN,Senzaki H,Maki T,Hase Y,Kitamura A,Washida K,Yamada M,Ito H,Tomimoto H,Takahashi R,Ihara M</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the effect of low cerebral perfusion on cerebral amyloid angiopathy</div> <div itemprodp="datePublished">Thu Mar 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22392442"> <div itemprop="name">Novel crystalloid oligodendrogliopathy in hereditary spastic paraplegia.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Woehrer A,Laszlo L,Finsterer J,Stöllberger C,Furtner J,Rinner W,Molnar K,Budka H,Kovacs GG</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study crystalloid oligodendrogliopathy in hereditary spastic paraplegia</div> <div itemprodp="datePublished">Mon Oct 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22544872"> <div itemprop="name">Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Petratos S,Ozturk E,Azari MF,Kenny R,Lee JY,Magee KA,Harvey AR,McDonald C,Taghian K,Moussa L,Mun Aui P,Siatskas C,Litwak S,Fehlings MG,Strittmatter SM,Bernard CC</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the effect of blocking the Nogo receptor and CRMP-2 phosphorylation on multiple sclerosis-related axonopathy</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22102449"> <div itemprop="name">The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies.</div> </a> <div itemprop="about">The Journal of pathology</div> <div itemprop="author">Nijholt DA,van Haastert ES,Rozemuller AJ,Scheper W,Hoozemans JJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the unfolded protein response in the hippocampus of tauopathies.</div> <div itemprodp="datePublished">Sun Apr 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22913544"> <div itemprop="name">Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and β-amyloid plaques in Alzheimer's disease models.</div> </a> <div itemprop="about">Journal of medicinal chemistry</div> <div itemprop="author">Boländer A,Kieser D,Voss C,Bauer S,Schön C,Burgold S,Bittner T,Hölzer J,Heyny-von Haußen R,Mall G,Goetschy V,Czech C,Knust H,Berger R,Herms J,Hilger I,Schmidt B</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the potential of fluorescent pyrazine, pyrimidine, and pyridazine derivatives for tau-based diagnosis of Alzhemer's disease</div> <div itemprodp="datePublished">Thu Nov 08 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22126211"> <div itemprop="name">Involvement of perineuronal and perisynaptic extracellular matrix in Alzheimer's disease neuropathology.</div> </a> <div itemprop="about">Brain pathology (Zurich, Switzerland)</div> <div itemprop="author">Morawski M,Brückner G,Jäger C,Seeger G,Matthews RT,Arendt T</div> <div itemprop="description">MN1020 was used in immunocytochemistry to investigate aggrecan-based perineuronal nets and brevican-based perisynaptic axonal coats in brains with amyloid plaques and neurofibrillary tangles</div> <div itemprodp="datePublished">Sun Jul 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21999410"> <div itemprop="name">Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adults.</div> </a> <div itemprop="about">Brain pathology (Zurich, Switzerland)</div> <div itemprop="author">Postupna N,Rose SE,Bird TD,Gonzalez-Cuyar LF,Sonnen JA,Larson EB,Keene CD,Montine TJ</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to obtain quantitative data from population-based studies and quantitative insights into latent AD that may guide expectations from neuroimaging and prevention studies.</div> <div itemprodp="datePublished">Sun Jul 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22262900"> <div itemprop="name">Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Sundaram JR,Chan ES,Poore CP,Pareek TK,Cheong WF,Shui G,Tang N,Low CM,Wenk MR,Kesavapany S</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the important roles of p25/Cdk5 in neuroinflammation and neurodegeneration</div> <div itemprodp="datePublished">Wed Jan 18 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22815492"> <div itemprop="name">Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Wang HY,Bakshi K,Frankfurt M,Stucky A,Goberdhan M,Shah SM,Burns LH</div> <div itemprop="description">MN1020 was used in western blot to study the ability of a small molecule that binds filamin A with high affinity to reduce beta-amyloid-associated Alzheimer's disease pathology</div> <div itemprodp="datePublished">Wed Jul 18 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22623658"> <div itemprop="name">Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Barten DM,Fanara P,Andorfer C,Hoque N,Wong PY,Husted KH,Cadelina GW,Decarr LB,Yang L,Liu V,Fessler C,Protassio J,Riff T,Turner H,Janus CG,Sankaranarayanan S,Polson C,Meredith JE,Gray G,Hanna A,Olson RE,Kim SH,Vite GD,Lee FY,Albright CF</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the effects of a small molecule microtubule-stabilizer on microtubule hyperdynamics, cognitive performance and pathology in tau transgenic mice</div> <div itemprodp="datePublished">Wed May 23 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23197718"> <div itemprop="name">SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Hong Y,Chan CB,Kwon IS,Li X,Song M,Lee HP,Liu X,Sompol P,Jin P,Lee HG,Yu SP,Ye K</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the ability of the cell cycle-regulated kinase SRPK2 to phosphorylate tau and the significance for Alzheimer's disease cognitive decline</div> <div itemprodp="datePublished">Wed Nov 28 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21726270"> <div itemprop="name">Hirano body-rich subtypes of Creutzfeldt-Jakob disease.</div> </a> <div itemprop="about">Neuropathology and applied neurobiology</div> <div itemprop="author">Martinez-Saez E,Gelpi E,Rey MJ,Ferrer I,Ribalta T,Botta-Orfila T,Nos C,Yagüe J,Sanchez-Valle R</div> <div itemprop="description">MN1020 was used in immunohistochemistry to detect Hirano bodies in neurons of Creutzfeldt-Jakob disease</div> <div itemprodp="datePublished">Sun Apr 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21718343"> <div itemprop="name">Immunohistochemical characterization of γ-secretase activating protein expression in Alzheimer's disease brains.</div> </a> <div itemprop="about">Neuropathology and applied neurobiology</div> <div itemprop="author">Satoh J,Tabunoki H,Ishida T,Saito Y,Arima K</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the changes of GSAP expression in Alzheimer disease patients</div> <div itemprodp="datePublished">Sun Apr 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22253473"> <div itemprop="name">Identification of oligomers at early stages of tau aggregation in Alzheimer's disease.</div> </a> <div itemprop="about">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</div> <div itemprop="author">Lasagna-Reeves CA,Castillo-Carranza DL,Sengupta U,Sarmiento J,Troncoso J,Jackson GR,Kayed R</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the important role of tau oligomers in Alzheimer disease brains</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22142809"> <div itemprop="name">Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Perez SE,Getova DP,He B,Counts SE,Geula C,Desire L,Coutadeur S,Peillon H,Ginsberg SD,Mufson EJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the expression of Raclb in cholinergic nucleus basalis neurones and the correlation with tau pathology and Alzheimer's disease progression</div> <div itemprodp="datePublished">Wed Feb 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22688056"> <div itemprop="name">Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Medeiros R,Kitazawa M,Chabrier MA,Cheng D,Baglietto-Vargas D,Kling A,Moeller A,Green KN,LaFerla FM</div> <div itemprop="description">MN1020 was used in western blot to study the beneficial effects of a novel calpain inhibitor on Alzheimers's disease pathology and cognitive decline in transgenic mouse model</div> <div itemprodp="datePublished">Wed Aug 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22115895"> <div itemprop="name">(Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains.</div> </a> <div itemprop="about">European journal of pharmacology</div> <div itemprop="author">Li L,Zhang ZF,Holscher C,Gao C,Jiang YH,Liu YZ</div> <div itemprop="description">MN1020 was used in western blot to investigate the effect of glucagon-like peptide-1 on the Alzheimer disease phenotype induced by streptozotocin</div> <div itemprodp="datePublished">Sun Jan 15 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21742415"> <div itemprop="name">Lack of detectable diffuse or neuritic plaques and neurofibrillary tangles in the brains of aged hamsters.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Gerhauser I,Wohlsein P,Ernst H,Germann PG,Baumgärtner W</div> <div itemprop="description">MN1020 was used in immunohistochemistry to evaluate Syrian hamsters as a useful animal model for Alzheimer disease</div> <div itemprodp="datePublished">Wed Aug 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21843906"> <div itemprop="name">Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Sheppard O,Plattner F,Rubin A,Slender A,Linehan JM,Brandner S,Tybulewicz VL,Fisher EM,Wiseman FK</div> <div itemprop="description">MN1020 was used in western blot to investigate the regulation of tau phosphorylation in Tc1 mice</div> <div itemprodp="datePublished">Sun Apr 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21546125"> <div itemprop="name">Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Orejana L,Barros-Miñones L,Jordán J,Puerta E,Aguirre N</div> <div itemprop="description">MN1020 was used in western blot to determine effect of sildenafil on age-related neurodeneration</div> <div itemprodp="datePublished">Thu Mar 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22177720"> <div itemprop="name">Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">García-Mesa Y,Giménez-Llort L,López LC,Venegas C,Cristòfol R,Escames G,Acuña-Castroviejo D,Sanfeliu C</div> <div itemprop="description">MN1020 was used in western blot to investigate the efficacy of exercise and melatonin in AD therapy</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20471717"> <div itemprop="name">Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Lee HJ,Lee JK,Lee H,Carter JE,Chang JW,Oh W,Yang YS,Suh JG,Lee BH,Jin HK,Bae JS</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the efficiency of human umbilical cord blood-derived mesenchymal stem cell transplantation in mouse model</div> <div itemprodp="datePublished">Thu Mar 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22169203"> <div itemprop="name">Autophagic degradation of tau in primary neurons and its enhancement by trehalose.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Krüger U,Wang Y,Kumar S,Mandelkow EM</div> <div itemprop="description">MN1020 was used in western blot to investigate the effect of trehalose on tau accumulation in AD patients</div> <div itemprodp="datePublished">Mon Oct 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20961664"> <div itemprop="name">Antemortem amyloid imaging and β-amyloid pathology in a case with dementia with Lewy bodies.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Kantarci K,Yang C,Schneider JA,Senjem ML,Reyes DA,Lowe VJ,Barnes LL,Aggarwal NT,Bennett DA,Smith GE,Petersen RC,Jack CR,Boeve BF</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the association of beta-amyloid and lewy body in a clinical case of dementia</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22922230"> <div itemprop="name">Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Dumont M,Stack C,Elipenahli C,Jainuddin S,Gerges M,Starkova N,Calingasan NY,Yang L,Tampellini D,Starkov AA,Chan RB,Di Paolo G,Pujol A,Beal MF</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the effects of the pan-PPAR agonist bezafibrate on inflammation, behaviour and tau pathology in a murine model</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22017610"> <div itemprop="name">Frontal cortex neuropathology in dementia pugilistica.</div> </a> <div itemprop="about">Journal of neurotrauma</div> <div itemprop="author">Saing T,Dick M,Nelson PT,Kim RC,Cribbs DH,Head E</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the neuropathological changes in dementia pugilistica patients</div> <div itemprodp="datePublished">Tue Apr 10 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21945393"> <div itemprop="name">Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models.</div> </a> <div itemprop="about">Molecular and cellular neurosciences</div> <div itemprop="author">Khandelwal PJ,Dumanis SB,Herman AM,Rebeck GW,Moussa CE</div> <div itemprop="description">MN1020 was used in western blot to investigate the effects of wild type and P301L mutant tau on neuro-inflammation and alpha-synuclein accumulation in a rat model</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22387731"> <div itemprop="name">Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats.</div> </a> <div itemprop="about">Neurotoxicology</div> <div itemprop="author">Rahman A,Khan KM,Al-Khaledi G,Khan I,Al-Shemary T</div> <div itemprop="description">MN1020 was used in western blot to study the role of hippocampal PP1 and PP2A activation in the deleterious effects of lead on learning and memory in a rat model</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22222439"> <div itemprop="name">Tau protein phosphorylation in diverse brain areas of normal and CRH deficient mice: up-regulation by stress.</div> </a> <div itemprop="about">Cellular and molecular neurobiology</div> <div itemprop="author">Filipcik P,Novak P,Mravec B,Ondicova K,Krajciova G,Novak M,Kvetnansky R</div> <div itemprop="description">MN1020 was used in western blot to characterize the role of tau protein phosphorylation in tau protein misfolding</div> <div itemprodp="datePublished">Sun Jul 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22045482"> <div itemprop="name">Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Cuadrado-Tejedor M,Ricobaraza A,Frechilla D,Franco R,Pérez-Mediavilla A,Garcia-Osta A</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the role of chronic mild stress in the pathogenesis of Alzheimer disease</div> <div itemprodp="datePublished">Fri Jun 15 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22406441"> <div itemprop="name">Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Clausen A,Xu X,Bi X,Baudry M</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the role of oxidative stress in Alzheimer's disease pathogenesis and progression</div> <div itemprodp="datePublished">Mon Sep 10 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22232007"> <div itemprop="name">Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-β in a fraction of amyloid-β deposits in Alzheimer's disease without cross-reactivity with other protein aggregates.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Venkataramani V,Wirths O,Budka H,Härtig W,Kovacs GG,Bayer TA</div> <div itemprop="description">MN1020 was used in immunohistochemistry to characterize a conformation-dependent amyloid beta monoclonal antibody</div> <div itemprodp="datePublished">Thu Jul 26 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21971408"> <div itemprop="name">Behavioral improvement after chronic administration of coenzyme Q10 in P301S transgenic mice.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Elipenahli C,Stack C,Jainuddin S,Gerges M,Yang L,Starkov A,Beal MF,Dumont M</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the behavioral benefit of coenzyme Q10 in P301S transgenic mice</div> <div itemprodp="datePublished">Wed Sep 12 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22233767"> <div itemprop="name">Decrease of the immunophilin FKBP52 accumulation in human brains of Alzheimer's disease and FTDP-17.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Giustiniani J,Sineus M,Sardin E,Dounane O,Panchal M,Sazdovitch V,Duyckaerts C,Chambraud B,Baulieu EE</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the change of the immunophilin FKBP52 in human brains of neurodegenerative diseases</div> <div itemprodp="datePublished">Thu Jul 26 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22008262"> <div itemprop="name">Breakpoint sequence analysis of an AβPP locus duplication associated with autosomal dominant Alzheimer's disease and severe cerebral amyloid angiopathy.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Antonell A,Gelpi E,Sánchez-Valle R,Martínez R,Molinuevo JL,Lladó A</div> <div itemprop="description">MN1020 was used in immunohistochemistry to analyze the breakpoint sequence of an APP locus duplication associated with autosomal dominant Alzheimer disease</div> <div itemprodp="datePublished">Thu May 24 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23159938"> <div itemprop="name">Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer's disease brain.</div> </a> <div itemprop="about">FEBS letters</div> <div itemprop="author">Yokota T,Akatsu H,Miyauchi T,Heese K</div> <div itemprop="description">MN1020 was used in western blot to study the potential involvement of the novel P9TLDR protein in Alzheimer's disease</div> <div itemprodp="datePublished">Fri Dec 14 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22664779"> <div itemprop="name">Nigral Tau pathology and striatal amyloid-β deposition does not correlate with striatal dopamine deficit in Alzheimer's disease.</div> </a> <div itemprop="about">Journal of neural transmission (Vienna, Austria : 1996)</div> <div itemprop="author">Schauer TH,Lochner M,Kovacs GG</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the lack of association between striatal dopamine deficit and nigral tau pathology and striatal amyloid-beta deposition</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22535301"> <div itemprop="name">Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease.</div> </a> <div itemprop="about">Metabolic brain disease</div> <div itemprop="author">Kapas I,Majtenyi K,Törö K,Keller E,Voigtländer T,Kovacs GG</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22561128"> <div itemprop="name">Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats.</div> </a> <div itemprop="about">Behavioural brain research</div> <div itemprop="author">Mustroph ML,King MA,Klein RL,Ramirez JJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the role of tauopathy on spatial working memory in a rat model</div> <div itemprodp="datePublished">Sun Jul 15 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22995177"> <div itemprop="name">STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease.</div> </a> <div itemprop="about">Neuroscience letters</div> <div itemprop="author">van Abel D,Abdulhamid O,Scheper W,van Dijk M,Oudejans CB</div> <div itemprop="description">MN1020 was used in western blot to study the induction of tau phosphorylation at sites hyperphosphorylated in Alzheimer's disease by over expression of the STOX1A transcription factor</div> <div itemprodp="datePublished">Wed Oct 24 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22272619"> <div itemprop="name">Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.</div> </a> <div itemprop="about">Current Alzheimer research</div> <div itemprop="author">Troquier L,Caillierez R,Burnouf S,Fernandez-Gomez FJ,Grosjean ME,Zommer N,Sergeant N,Schraen-Maschke S,Blum D,Buee L</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the therapeutic efficacy of active immunization with a phospho-serine 422 Tau peptide in a murine transgenic Tau model</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22351109"> <div itemprop="name">Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.</div> </a> <div itemprop="about">Journal of molecular neuroscience : MN</div> <div itemprop="author">Löffler T,Flunkert S,Taub N,Schofield EL,Ward MA,Windisch M,Hutter-Paier B</div> <div itemprop="description">MN1020 was used in western blot to develop a cell line stably expressing mutant tau441 for screening Alzheimer's disease drug candidates</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21692862"> <div itemprop="name">"Preclinical" MSA in definite Creutzfeldt-Jakob disease.</div> </a> <div itemprop="about">Neuropathology : official journal of the Japanese Society of Neuropathology</div> <div itemprop="author">Rodriguez-Diehl R,Rey MJ,Gironell A,Martinez-Saez E,Ferrer I,Sánchez-Valle R,Jagüe J,Nos C,Gelpi E</div> <div itemprop="description">MN1020 was used in immunohistochemistry to report on a case of co-existing multiple system atrophy and Creutzfeldt-Jakob disease</div> <div itemprodp="datePublished">Sun Apr 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21518013"> <div itemprop="name">Unusual clinical presentation and neuropathology in two subjects with fused-in sarcoma (FUS) positive inclusions.</div> </a> <div itemprop="about">Neuropathology : official journal of the Japanese Society of Neuropathology</div> <div itemprop="author">Hartikainen PH,Pikkarainen M,Hänninen T,Soininen H,Alafuzoff I</div> <div itemprop="description">MN1020 was used in immunohistochemistry to describe atypical clinical symptoms in two patients with frontotemporal lobar degeneration</div> <div itemprodp="datePublished">Wed Feb 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22547371"> <div itemprop="name">Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice.</div> </a> <div itemprop="about">Experimental brain research</div> <div itemprop="author">Fine JM,Baillargeon AM,Renner DB,Hoerster NS,Tokarev J,Colton S,Pelleg A,Andrews A,Sparley KA,Krogh KM,Frey WH,Hanson LR</div> <div itemprop="description">MN1020 was used in western blot to study the molecular and behavioural effects of deferoxamine in tau transgenic mice</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22018806"> <div itemprop="name">Squirrel monkeys (Saimiri sciureus) infected with the agent of bovine spongiform encephalopathy develop tau pathology.</div> </a> <div itemprop="about">Journal of comparative pathology</div> <div itemprop="author">Piccardo P,Cervenak J,Yakovleva O,Gregori L,Pomeroy K,Cook A,Muhammad FS,Seuberlich T,Cervenakova L,Asher DM</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the tau pathology in squirrel monkeys after infection with the agent of bovine spongiform encephalopathy</div> <div itemprodp="datePublished">Sun Jul 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23134599"> <div itemprop="name">Early postnatal lead exposure induces tau phosphorylation in the brain of young rats.</div> </a> <div itemprop="about">Acta biologica Hungarica</div> <div itemprop="author">Rahman A,Khan KM,Al-Khaledi G,Khan I,Attur S</div> <div itemprop="description">MN1020 was used in western blot to study tau phosphorylation in response to early post-natal exposure to lead</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22347510"> <div itemprop="name">Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Sudduth TL,Wilson JG,Everhart A,Colton CA,Wilcock DM</div> <div itemprop="description">MN1020 was used in immunohistochemistry and western blot to study the effect of lithium treatment on tau hyperphosphorylation and amyloid deposition in a model of Alzheimer's disease</div> <div itemprodp="datePublished">Tue Jul 31 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22666365"> <div itemprop="name">Intranasal "painless" human Nerve Growth Factor [corrected] slows amyloid neurodegeneration and prevents memory deficits in App X PS1 mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Capsoni S,Marinelli S,Ceci M,Vignone D,Amato G,Malerba F,Paoletti F,Meli G,Viegi A,Pavone F,Cattaneo A</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the therapeutic effect of intranasal delivery of nerve growth factor in a modelof Alzheimer's disease</div> <div itemprodp="datePublished">Mon Oct 29 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22998728"> <div itemprop="name">Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.</div> </a> <div itemprop="about">Molecular neurodegeneration</div> <div itemprop="author">Inoue K,Rispoli J,Kaphzan H,Klann E,Chen EI,Kim J,Komatsu M,Abeliovich A</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the role of the phospho-Tau pathway in the mechanism by which deficient macroautophagy promotes age-related neurodegeneration</div> <div itemprodp="datePublished">Fri Sep 21 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22303461"> <div itemprop="name">LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Kawakami F,Yabata T,Ohta E,Maekawa T,Shimada N,Suzuki M,Maruyama H,Ichikawa T,Obata F</div> <div itemprop="description">MN1020 was used in western blot to investigate the important roles of LRRK2 in phosphorylation-mediated dissociation of tau from microtubules</div> <div itemprodp="datePublished">Mon Jun 11 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22348084"> <div itemprop="name">Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Caesar I,Jonson M,Nilsson KP,Thor S,Hammarström P</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the effect of curcumin on A-beta fibrillation and neurotoxicity in transgenic Drosophila</div> <div itemprodp="datePublished">Tue Jul 31 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22984603"> <div itemprop="name">Organotypic brain slice cultures of adult transgenic P301S mice--a model for tauopathy studies.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Mewes A,Franke H,Singer D</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to study the benefits and limitations of organotypic brain slice cultures made of mature adult transgenic mice as a potential model system for the multifactorial phenotype of Alzheimer's disease.</div> <div itemprodp="datePublished">Tue Mar 05 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22870188"> <div itemprop="name">Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Castello NA,Green KN,LaFerla FM</div> <div itemprop="description">MN1020 was used in western blot to study the lack of effect of BDNF knockdown on Abeta or tau pathology in a model of Alzheimer's disease</div> <div itemprodp="datePublished">Tue Feb 19 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22833681"> <div itemprop="name">Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Mondragón-Rodríguez S,Trillaud-Doppia E,Dudilot A,Bourgeois C,Lauzon M,Leclerc N,Boehm J</div> <div itemprop="description">MN1020 was used in immunocytochemistry to study the role of NMDA receptor-dependent tau phosphorylation in modulating the interaction of endogenous tau with synaptic proteins</div> <div itemprodp="datePublished">Fri Sep 14 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22511769"> <div itemprop="name">Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Matsushima T,Saito Y,Elliott JI,Iijima-Ando K,Nishimura M,Kimura N,Hata S,Yamamoto T,Nakaya T,Suzuki T</div> <div itemprop="description">MN1020 was used in western blot to study the role of phosphorylation in the membrane-microdomain localization of amyloid ?-precursor protein C-terminal fragments</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23056312"> <div itemprop="name">Neurofibrillary tangles and the deposition of a beta amyloid peptide with a novel N-terminal epitope in the brains of wild Tsushima leopard cats.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Chambers JK,Uchida K,Harada T,Tsuboi M,Sato M,Kubo M,Kawaguchi H,Miyoshi N,Tsujimoto H,Nakayama H</div> <div itemprop="description">MN1020 was used in immunohistochemistry - paraffin section to identify and characterize Abeta deposits in the brains of Japanese Tsushima leopard cats</div> <div itemprodp="datePublished">Tue Jun 11 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22457786"> <div itemprop="name">Transient focal cerebral ischemia/reperfusion induces early and chronic axonal changes in rats: its importance for the risk of Alzheimer's disease.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Zhang Q,Gao T,Luo Y,Chen X,Gao G,Gao X,Zhou Y,Dai J</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the early and chronic axonal changes caused by transient focal cerebral ischemia-reperfusion and the significance for Alzheimer's disease pathogenesis</div> <div itemprodp="datePublished">Fri Aug 03 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23029293"> <div itemprop="name">Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Harris JA,Koyama A,Maeda S,Ho K,Devidze N,Dubal DB,Yu GQ,Masliah E,Mucke L</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study whether tau pathology caused by overexpression of mutant P301L tau in the murine entorhinal-hippocampal network leads to cognitive defects</div> <div itemprodp="datePublished">Thu Feb 28 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22989354"> <div itemprop="name">Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Britschgi M,Takeda-Uchimura Y,Rockenstein E,Johns H,Masliah E,Wyss-Coray T</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the potential role of the central and terminal complement pathways in tau neuropathology</div> <div itemprodp="datePublished">Tue Sep 18 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23319189"> <div itemprop="name">Hemimegalencephaly: foetal tauopathy with mTOR hyperactivation and neuronal lipidosis.</div> </a> <div itemprop="about">Folia neuropathologica</div> <div itemprop="author">Sarnat H,Flores-Sarnat L,Crino P,Hader W,Bello-Espinosa L</div> <div itemprop="description">MN1020 was used in immunohistochemistry to report on three cases of hemimegalencephaly</div> <div itemprodp="datePublished">Wed Nov 13 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23144624"> <div itemprop="name">Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration.</div> </a> <div itemprop="about">PLoS genetics</div> <div itemprop="author">Merkwirth C,Martinelli P,Korwitz A,Morbin M,Brönneke HS,Jordan SD,Rugarli EI,Langer T</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study tau hyperphosphorylation and neurodegeneration induced by loss of murine neuronal PHB2</div> <div itemprodp="datePublished">Mon May 13 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22761989"> <div itemprop="name">Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Bretteville A,Marcouiller F,Julien C,El Khoury NB,Petry FR,Poitras I,Mouginot D,Lévesque G,Hébert SS,Planel E</div> <div itemprop="description">MN1020 was used in western blot to test if hypothermia could be used to assess tau kinase inhibitors efficacy</div> <div itemprodp="datePublished">Sun Mar 17 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21847625"> <div itemprop="name">Microglial pathology in Down syndrome.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Xue QS,Streit WJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the changes of microglial cells in Down syndrome patients</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21170538"> <div itemprop="name">The pathological process underlying Alzheimer's disease in individuals under thirty.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Braak H,Del Tredici K</div> <div itemprop="description">MN1020 was used in immunocytochemistry to investigate the changes of gene expression in young Alzheimer disease patients</div> <div itemprodp="datePublished">Tue Feb 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22009197"> <div itemprop="name">Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">Li X,Kumar Y,Zempel H,Mandelkow EM,Biernat J,Mandelkow E</div> <div itemprop="description">MN1020 was used in western blot to investigate the mechanism for the tau missorting in Alzheimer disease</div> <div itemprodp="datePublished">Tue Oct 18 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21616478"> <div itemprop="name">Cyclin-dependent kinase 5 activator p25 is generated during memory formation and is reduced at an early stage in Alzheimer's disease.</div> </a> <div itemprop="about">Biological psychiatry</div> <div itemprop="author">Engmann O,Hortobágyi T,Thompson AJ,Guadagno J,Troakes C,Soriano S,Al-Sarraj S,Kim Y,Giese KP</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the generation of the p25 Cdk5 activator during spatial memory formation and its reduction in early stage Alzheimer's disease</div> <div itemprodp="datePublished">Fri Jul 15 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21416488"> <div itemprop="name">ST101 induces a novel 17 kDa APP cleavage that precludes Aβ generation in vivo.</div> </a> <div itemprop="about">Annals of neurology</div> <div itemprop="author">Green KN,Khashwji H,Estrada T,Laferla FM</div> <div itemprop="description">MN1020 was used in western blot to investigate the effect of ZSET 1446 on APP digestion in vivo</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21484863"> <div itemprop="name">Rapidly progressive diffuse Lewy body disease.</div> </a> <div itemprop="about">Movement disorders : official journal of the Movement Disorder Society</div> <div itemprop="author">Gaig C,Valldeoriola F,Gelpi E,Ezquerra M,Llufriu S,Buongiorno M,Rey MJ,Martí MJ,Graus F,Tolosa E</div> <div itemprop="description">MN1020 was used in immunohistochemistry to evaluate clinical and neuropathological features of patients with a rapidly progressive diffuse Lewy body disease</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21259341"> <div itemprop="name">Clinical correlates of similar pathologies in parkinsonian syndromes.</div> </a> <div itemprop="about">Movement disorders : official journal of the Movement Disorder Society</div> <div itemprop="author">Song YJ,Huang Y,Halliday GM</div> <div itemprop="description">MN1020 was used in immunohistochemistry to conduct the pathological analysis in parkinsonian syndromes</div> <div itemprodp="datePublished">Tue Feb 15 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21627640"> <div itemprop="name">Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">British journal of pharmacology</div> <div itemprop="author">Cuadrado-Tejedor M,Hervias I,Ricobaraza A,Puerta E,Pérez-Roldán JM,García-Barroso C,Franco R,Aguirre N,García-Osta A</div> <div itemprop="description">MN1020 was used in western blot to study the effect of sildenafil on neuroplasticity related to Alzheimer</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20967887"> <div itemprop="name">WNT signaling in activated microglia is proinflammatory.</div> </a> <div itemprop="about">Glia</div> <div itemprop="author">Halleskog C,Mulder J,Dahlström J,Mackie K,Hortobágyi T,Tanila H,Kumar Puli L,Färber K,Harkany T,Schulte G</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the involvement of WNT signaling in inflammatory response in microglia</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21435071"> <div itemprop="name">Encephalopathy with neuroserpin inclusion bodies presenting as progressive myoclonus epilepsy and associated with a novel mutation in the Proteinase Inhibitor 12 gene.</div> </a> <div itemprop="about">Brain pathology (Zurich, Switzerland)</div> <div itemprop="author">Hagen MC,Murrell JR,Delisle MB,Andermann E,Andermann F,Guiot MC,Ghetti B</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the role of PI12 mutation on neuronal pathologenesis</div> <div itemprodp="datePublished">Thu Sep 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20731657"> <div itemprop="name">Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain.</div> </a> <div itemprop="about">Brain pathology (Zurich, Switzerland)</div> <div itemprop="author">Wilhelmus MM,Verhaar R,Andringa G,Bol JG,Cras P,Shan L,Hoozemans JJ,Drukarch B</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the presence of tissue transglutaminase in melanized neurons in Parkinson's disease brain</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21159009"> <div itemprop="name">Deposition of hyperphosphorylated tau in cerebellum of PS1 E280A Alzheimer's disease.</div> </a> <div itemprop="about">Brain pathology (Zurich, Switzerland)</div> <div itemprop="author">Sepulveda-Falla D,Matschke J,Bernreuther C,Hagel C,Puig B,Villegas A,Garcia G,Zea J,Gomez-Mancilla B,Ferrer I,Lopera F,Glatzel M</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the distribution of phosphorylated tau in Alzheimer disease patients</div> <div itemprodp="datePublished">Fri Jul 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21303697"> <div itemprop="name">Loss of amyloid precursor protein in a mouse model of Niemann-Pick type C disease exacerbates its phenotype and disrupts tau homeostasis.</div> </a> <div itemprop="about">Neurobiology of disease</div> <div itemprop="author">Nunes A,Pressey SN,Cooper JD,Soriano S</div> <div itemprop="description">MN1020 was used in western blot to study the status of amyloid precursor protein in a Niemann-Pick type C disease mouse model and its effect on tau homeostasis</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21569847"> <div itemprop="name">Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology.</div> </a> <div itemprop="about">Neurobiology of disease</div> <div itemprop="author">Belarbi K,Burnouf S,Fernandez-Gomez FJ,Laurent C,Lestavel S,Figeac M,Sultan A,Troquier L,Leboucher A,Caillierez R,Grosjean ME,Demeyer D,Obriot H,Brion I,Barbot B,Galas MC,Staels B,Humez S,Sergeant N,Schraen-Maschke S,Muhr-Tailleux A,Hamdane M,Buée L,Blum D</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the influence of long-term voluntary exercise on a transgenic mouse model of Tau pathology</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20937383"> <div itemprop="name">Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice.</div> </a> <div itemprop="about">Neurobiology of disease</div> <div itemprop="author">Perez SE,He B,Muhammad N,Oh KJ,Fahnestock M,Ikonomovic MD,Mufson EJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the changes of cholinotrophic system in Alzheimer disease mouse model</div> <div itemprodp="datePublished">Tue Feb 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21289177"> <div itemprop="name">Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Shipton OA,Leitz JR,Dworzak J,Acton CE,Tunbridge EM,Denk F,Dawson HN,Vitek MP,Wade-Martins R,Paulsen O,Vargas-Caballero M</div> <div itemprop="description">MN1020 was used in western blot to study the role of Abeta in Tau phosphorylation and its mechanism</div> <div itemprodp="datePublished">Wed Feb 02 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21248115"> <div itemprop="name">A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Dusonchet J,Kochubey O,Stafa K,Young SM,Zufferey R,Moore DJ,Schneider BL,Aebischer P</div> <div itemprop="description">MN1020 was used in immunohistochemistry to generate a rat model using the mutant G2019S of LRRK2 to study Parkinson's disease.</div> <div itemprodp="datePublished">Wed Jan 19 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21325519"> <div itemprop="name">Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Sydow A,Van der Jeugd A,Zheng F,Ahmed T,Balschun D,Petrova O,Drexler D,Zhou L,Rune G,Mandelkow E,D'Hooge R,Alzheimer C,Mandelkow EM</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the effect of Tau mutations on the behavior and electrophysiology of mice</div> <div itemprodp="datePublished">Wed Feb 16 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21442128"> <div itemprop="name">Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies.</div> </a> <div itemprop="about">Molecular medicine (Cambridge, Mass.)</div> <div itemprop="author">Ferreira A,Bigio EH</div> <div itemprop="description">MN1020 was used in western blot to investigate tau cleavage mediated by calpain and its relationship with tau aggregation in tauopathies</div> <div itemprodp="datePublished">Tue Dec 27 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21825035"> <div itemprop="name">Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice.</div> </a> <div itemprop="about">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</div> <div itemprop="author">Dumont M,Stack C,Elipenahli C,Jainuddin S,Gerges M,Starkova NN,Yang L,Starkov AA,Beal F</div> <div itemprop="description">MN1020 was used in western blot to determine the role of oxidative stress in neurodegenerative disease progression</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21907175"> <div itemprop="name">Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Wilhelmus MM,Bol JG,Van Haastert ES,Rozemuller AJ,Bu G,Drukarch B,Hoozemans JJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the potential roles of ApoE1 and LRP1 in the pathogenesis of Parkinson's disease</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21596710"> <div itemprop="name">A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug.</div> </a> <div itemprop="about">Disease models & mechanisms</div> <div itemprop="author">Copenhaver PF,Anekonda TS,Musashe D,Robinson KM,Ramaker JM,Swanson TL,Wadsworth TL,Kretzschmar D,Woltjer RL,Quinn JF</div> <div itemprop="description">MN1020 was used in western blot to study the role of calcium homeostasis in Alzheimer disease using four model systems</div> <div itemprodp="datePublished">Thu Sep 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21968813"> <div itemprop="name">A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules.</div> </a> <div itemprop="about">Laboratory investigation; a journal of technical methods and pathology</div> <div itemprop="author">Castellani RJ,Gupta Y,Sheng B,Siedlak SL,Harris PL,Coller JM,Perry G,Lee HG,Tabaton M,Smith MA,Wang X,Zhu X</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the phosphorylated ribosomal protein S6 in aging and Alzheimer disease</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19775775"> <div itemprop="name">Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Hall EC,Lee SY,Mairuae N,Simmons Z,Connor JR</div> <div itemprop="description">MN1020 was used in western blot to test if HFE polymorphisms are associated with alterations in tau phosphorylation in a human neuroblastoma cell line</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21949350"> <div itemprop="name">Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Ambegaokar SS,Jackson GR</div> <div itemprop="description">MN1020 was used in western blot to identify modifiers of tau toxicity and their relationships with tau phosphorylation state</div> <div itemprodp="datePublished">Thu Dec 15 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21659825"> <div itemprop="name">Knockout of the vascular endothelial glucocorticoid receptor abrogates dexamethasone-induced hypertension.</div> </a> <div itemprop="about">Journal of hypertension</div> <div itemprop="author">Goodwin JE,Zhang J,Gonzalez D,Albinsson S,Geller DS</div> <div itemprop="description">MN1020 was used in immunocytochemistry to investigate the role of the vasculature in the generation and maintenance of glucocorticoid-mediated hypertension</div> <div itemprodp="datePublished">Fri Jul 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21907746"> <div itemprop="name">13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro.</div> </a> <div itemprop="about">Neurochemistry international</div> <div itemprop="author">Alonso E,Vale C,Vieytes MR,Laferla FM,Giménez-Llort L,Botana LM</div> <div itemprop="description">MN1020 was used in western blot to investigate the effect of 13-desmethyl spirolide-C on both tau and beta-amyloid peptide</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21694451"> <div itemprop="name">Amyloid-β-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Silva DF,Esteves AR,Arduino DM,Oliveira CR,Cardoso SM</div> <div itemprop="description">MN1020 was used in western blot to investigate the impairment of autophagic lysosomal pathway caused by amyloid-beta-induced mitochondrial dysfunction</div> <div itemprodp="datePublished">Wed Jan 11 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21628793"> <div itemprop="name">JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Ploia C,Antoniou X,Sclip A,Grande V,Cardinetti D,Colombo A,Canu N,Benussi L,Ghidoni R,Forloni G,Borsello T</div> <div itemprop="description">MN1020 was used in immunocytochemistry and western blot to study the contribution of JNK in tau hyperphosphorylation.</div> <div itemprodp="datePublished">Tue Jan 17 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21628793"> <div itemprop="name">JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Ploia C,Antoniou X,Sclip A,Grande V,Cardinetti D,Colombo A,Canu N,Benussi L,Ghidoni R,Forloni G,Borsello T</div> <div itemprop="description">MN1020 was used in immunocytochemistry and western blot to study the contribution of JNK in tau hyperphosphorylation.</div> <div itemprodp="datePublished">Tue Jan 17 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21541771"> <div itemprop="name">Fronto-temporal lobar degeneration: neuropathology in 60 cases.</div> </a> <div itemprop="about">Journal of neural transmission (Vienna, Austria : 1996)</div> <div itemprop="author">Seilhean D,Le Ber I,Sarazin M,Lacomblez L,Millecamps S,Salachas F,Pradat PF,Le Forestier N,LeGuern E,Dubois B,Meininger V,Brice A,Hauw JJ,Duyckaerts C</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the neuropathology of fronto-temporal lobar degeneration patients</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21052746"> <div itemprop="name">Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson's disease cases.</div> </a> <div itemprop="about">Journal of neural transmission (Vienna, Austria : 1996)</div> <div itemprop="author">Braak H,Thal DR,Del Tredici K</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the localization of p62 in specific brain regions of Parkinson disease patients</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21157377"> <div itemprop="name">Protein aggregation in the aging retina.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Leger F,Fernagut PO,Canron MH,Léoni S,Vital C,Tison F,Bezard E,Vital A</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the age-related protein aggregation in retina</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21760538"> <div itemprop="name">Peripheral neuropathy is linked to a severe form of myotonic dystrophy in transgenic mice.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Panaite PA,Kielar M,Kraftsik R,Gourdon G,Kuntzer T,Barakat-Walter I</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the role of peripheral neuropathy in myotonic dystrophy</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22002422"> <div itemprop="name">Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Braak H,Thal DR,Ghebremedhin E,Del Tredici K</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the progression of Alzheimer disease and the association between tauopathy and Alzheimer disease</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22002427"> <div itemprop="name">Truncation of tau at E391 promotes early pathologic changes in transgenic mice.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">McMillan PJ,Kraemer BC,Robinson L,Leverenz JB,Raskind M,Schellenberg G</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the role of a truncated tau in Alzheimer disease pathogenesis in mice</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21412171"> <div itemprop="name">Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Glöckner F,Meske V,Lütjohann D,Ohm TG</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the effect of dietary cholesterol on phosphorylation and aggregation of tau protein</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20838929"> <div itemprop="name">Caffeine modulates tau phosphorylation and affects Akt signaling in postmitotic neurons.</div> </a> <div itemprop="about">Journal of molecular neuroscience : MN</div> <div itemprop="author">Currais A,Kato K,Canuet L,Ishii R,Tanaka T,Takeda M,Soriano S</div> <div itemprop="description">MN1020 was used in western blot to investigate the effect of caffeine on tau phosphorylation and Akt signaling</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20621427"> <div itemprop="name">αB-crystallin negative astrocytic inclusions.</div> </a> <div itemprop="about">Brain & development</div> <div itemprop="author">Barnett BP,Bressler J,Chen T,Hutchins GM,Crain BJ,Kaufmann WE</div> <div itemprop="description">MN1020 was used in immunohistochemistry to describe the pathology of astrocyte inclusions.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21235806"> <div itemprop="name">Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Fonseca MI,Chu SH,Berci AM,Benoit ME,Peters DG,Kimura Y,Tenner AJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the role of complement activation pathways in Alzheimer disease</div> <div itemprodp="datePublished">Sat Jan 15 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21267079"> <div itemprop="name">The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Stieler JT,Bullmann T,Kohl F,Tøien Ø,Brückner MK,Härtig W,Barnes BM,Arendt T</div> <div itemprop="description">MN1020 was used in immunohistochemistry and western blot to study the physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation</div> <div itemprodp="datePublished">Tue Jan 18 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21569259"> <div itemprop="name">FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases.</div> </a> <div itemprop="about">BMC neurology</div> <div itemprop="author">Rusina R,Kovacs GG,Fiala J,Hort J,Ridzoň P,Holmerová I,Ströbel T,Matěj R</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the different phenotypes of TDP-43 proteinopathies</div> <div itemprodp="datePublished">Tue May 10 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21771791"> <div itemprop="name">CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Cho SH,Sun B,Zhou Y,Kauppinen TM,Halabisky B,Wes P,Ransohoff RM,Gan L</div> <div itemprop="description">MN1020 was used in western blot to study the role of CX3CR1 protein in microglial activation and cognitive deficits in Alzheimer disease mouse model</div> <div itemprodp="datePublished">Fri Sep 16 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21390302"> <div itemprop="name">Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Talbot K,Louneva N,Cohen JW,Kazi H,Blake DJ,Arnold SE</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the changes of dysbindin-1 in schizophrenia patients</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22087282"> <div itemprop="name">Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Maarouf CL,Daugs ID,Kokjohn TA,Walker DG,Hunter JM,Kruchowsky JC,Woltjer R,Kaye J,Castaño EM,Sabbagh MN,Beach TG,Roher AE</div> <div itemprop="description">MN1020 was used in western blot to examine the brains of non-demented high pathology controls individuals for mechanisms that protect against Alzheimer's disease</div> <div itemprodp="datePublished">Fri May 18 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21559186"> <div itemprop="name">Influence of water quality on cholesterol-induced tau pathology: preliminary data.</div> </a> <div itemprop="about">International journal of Alzheimer's disease</div> <div itemprop="author">Sparks DL,Ziolkowski C,Lawmaster T,Martin T</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the effect of water quality on tau pathology induced by cholesterol in a rabbit model</div> <div itemprodp="datePublished">Sun Apr 17 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21347323"> <div itemprop="name">The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">To AW,Ribe EM,Chuang TT,Schroeder JE,Lovestone S</div> <div itemprop="description">MN1020 was used in western blot to study the amyloid beta and tau pathology in APOE knockout mice, carrying human APOEepsilon3 or epsilon4 transgenes, after diet-induced insulin resistance with and without pioglitazone treatment</div> <div itemprodp="datePublished">Thu Feb 10 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21304998"> <div itemprop="name">Propofol directly increases tau phosphorylation.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Whittington RA,Virág L,Marcouiller F,Papon MA,El Khoury NB,Julien C,Morin F,Emala CW,Planel E</div> <div itemprop="description">MN1020 was used in immunocytochemistry to study the effect of propofol on tau phosphorylation</div> <div itemprodp="datePublished">Mon Jan 31 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20357768"> <div itemprop="name">Caspase activation precedes and leads to tangles.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">de Calignon A,Fox LM,Pitstick R,Carlson GA,Bacskai BJ,Spires-Jones TL,Hyman BT</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the effect of caspase activation on tangle formation</div> <div itemprodp="datePublished">Thu Apr 22 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20869593"> <div itemprop="name">Acetylation of tau inhibits its degradation and contributes to tauopathy.</div> </a> <div itemprop="about">Neuron</div> <div itemprop="author">Min SW,Cho SH,Zhou Y,Schroeder S,Haroutunian V,Seeley WW,Huang EJ,Shen Y,Masliah E,Mukherjee C,Meyers D,Cole PA,Ott M,Gan L</div> <div itemprop="description">MN1020 was used in western blot to investigate the effect of tau modification on its stability and function in neurons</div> <div itemprodp="datePublished">Thu Sep 23 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20697724"> <div itemprop="name">Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Blanchard J,Wanka L,Tung YC,Cárdenas-Aguayo Mdel C,LaFerla FM,Iqbal K,Grundke-Iqbal I</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the therapeutic enhancement of neuronal generation and plasticity in a model of Alzheimer's disease.</div> <div itemprodp="datePublished">Mon Nov 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20379728"> <div itemprop="name">Amyotrophic lateral sclerosis: dash-like accumulation of phosphorylated TDP-43 in somatodendritic and axonal compartments of somatomotor neurons of the lower brainstem and spinal cord.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Braak H,Ludolph A,Thal DR,Del Tredici K</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the phosphorylation and accumulation of TDP-43 in brainstem and spinal cord in amyotrophic lateral sclerosis</div> <div itemprodp="datePublished">Thu Jul 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20229352"> <div itemprop="name">Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Del Tredici K,Hawkes CH,Ghebremedhin E,Braak H</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the submandibular gland of patients with Parkinson disease, incidental Lewy body disease, and multiple system atrophy</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20693541"> <div itemprop="name">Very early-onset frontotemporal dementia with no family history predicts underlying fused in sarcoma pathology.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Loy CT,McCusker E,Kril JJ,Kwok JB,Brooks WS,McCann H,Isaacs AM,Halliday GM</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the pathological manifestation of very early-onset frontotemporal dementia</div> <div itemprodp="datePublished">Wed Dec 01 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20562453"> <div itemprop="name">Isolated bulbar paralysis in a patient with medullar tau pathology: a case report.</div> </a> <div itemprop="about">Journal of neurology, neurosurgery, and psychiatry</div> <div itemprop="author">Pretnar-Oblak J,Zaletel M,Hajnsek TM,Meglic B,Hocevar-Boltezar I,Popovic M</div> <div itemprop="description">MN1020 was used in immunohistochemistry to report a clinical case of medullar tau pathology with isolated bulbar paralysis</div> <div itemprodp="datePublished">Sun Aug 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20643941"> <div itemprop="name">Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">van Eersel J,Ke YD,Liu X,Delerue F,Kril JJ,Götz J,Ittner LM</div> <div itemprop="description">MN1020 was used in western blot to investigate the effect of sodium selenate on tau pathology</div> <div itemprodp="datePublished">Tue Aug 03 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20368688"> <div itemprop="name">Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice.</div> </a> <div itemprop="about">Experimental & molecular medicine</div> <div itemprop="author">Lee JH,Won SM,Suh J,Son SJ,Moon GJ,Park UJ,Gwag BJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry to examine the correlation between induction of the unfolded protein response and neurofibrillary tangle</div> <div itemprodp="datePublished">Mon May 31 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20876489"> <div itemprop="name">Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2.</div> </a> <div itemprop="about">Stroke</div> <div itemprop="author">Van Nostrand WE,Xu F,Rozemuller AJ,Colton CA</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study cerebral amyloid angiopathy in mice lacking nitric oxide synthase-2.</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20209627"> <div itemprop="name">Hyposmia in progressive supranuclear palsy.</div> </a> <div itemprop="about">Movement disorders : official journal of the Movement Disorder Society</div> <div itemprop="author">Silveira-Moriyama L,Hughes G,Church A,Ayling H,Williams DR,Petrie A,Holton J,Revesz T,Kingsbury A,Morris HR,Burn DJ,Lees AJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the changes of smell capability in progressive supranuclear palsy</div> <div itemprodp="datePublished">Thu Apr 15 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20336061"> <div itemprop="name">Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology.</div> </a> <div itemprop="about">Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology</div> <div itemprop="author">Escribano L,Simón AM,Gimeno E,Cuadrado-Tejedor M,López de Maturana R,García-Osta A,Ricobaraza A,Pérez-Mediavilla A,Del Río J,Frechilla D</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the effect of rosiglitazone on memory rescue in Alzheimer disease patients and its mechanism</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20737479"> <div itemprop="name">Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis.</div> </a> <div itemprop="about">Glia</div> <div itemprop="author">Höftberger R,Fink S,Aboul-Enein F,Botond G,Olah J,Berki T,Ovadi J,Lassmann H,Budka H,Kovacs GG</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the expression tubulin polymerization promoting protein in oligodendrocytes in multiple sclerosis</div> <div itemprodp="datePublished">Mon Nov 15 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20381619"> <div itemprop="name">Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish.</div> </a> <div itemprop="about">Neurobiology of disease</div> <div itemprop="author">van Bebber F,Paquet D,Hruscha A,Schmid B,Haass C</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the non-effectiveness of methylene blue on tau function and polyglutamine toxicity in zebrafish</div> <div itemprodp="datePublished">Wed Sep 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21147995"> <div itemprop="name">Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Boutajangout A,Quartermain D,Sigurdsson EM</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the effect of immunotherapy on cognitive decline in mouse</div> <div itemprodp="datePublished">Wed Dec 08 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21048150"> <div itemprop="name">Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Tamayev R,Giliberto L,Li W,d'Abramo C,Arancio O,Vidal R,D'Adamio L</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the influence of BRI2 mutation on learning and memory in mice</div> <div itemprodp="datePublished">Wed Nov 03 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20609109"> <div itemprop="name">Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy.</div> </a> <div itemprop="about">Neuropathology and applied neurobiology</div> <div itemprop="author">Bhaskar K,Hobbs GA,Yen SH,Lee G</div> <div itemprop="description">MN1020 was used in immunohistochemistry to compare the temporal and spatial distribution of Tyr18-phosphorylated tau with that of Ser202/Thr205-phosphorylated tau in the JNPL3 mouse model</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20102518"> <div itemprop="name">Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer's disease.</div> </a> <div itemprop="about">Neuropathology and applied neurobiology</div> <div itemprop="author">Ma JF,Huang Y,Chen SD,Halliday G</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the pathological structures associated with macroautophagy in neurons and endothelial cells in Alzheimer disease</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20014009"> <div itemprop="name">Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease mice by modulation of immune responses.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Lee JK,Jin HK,Endo S,Schuchman EH,Carter JE,Bae JS</div> <div itemprop="description">MN1020 was used in immunohistochemistry to evaluate bone marrow-derived mesenchymal stem cells as potential cellular therapy for Alzheimer disease</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20042680"> <div itemprop="name">Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Martinez-Coria H,Green KN,Billings LM,Kitazawa M,Albrecht M,Rammes G,Parsons CG,Gupta S,Banerjee P,LaFerla FM</div> <div itemprop="description">MN1020 was used in western blot to investigate the effect of memantine on Alzheimer disease treatment in mice</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20472896"> <div itemprop="name">Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Koike MA,Green KN,Blurton-Jones M,Laferla FM</div> <div itemprop="description">MN1020 was used in western blot to investigate the effect of oligemic hypoperfusion on tau and amyloid-beta in 3xTg-Alzheimer disease mice</div> <div itemprodp="datePublished">Thu Jul 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20864679"> <div itemprop="name">CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Lee S,Varvel NH,Konerth ME,Xu G,Cardona AE,Ransohoff RM,Lamb BT</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the influence of CX3CR1 deletion on A-beta accumulation in Alzheimer disease models</div> <div itemprodp="datePublished">Mon Nov 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18760507"> <div itemprop="name">Early diagnostic accuracy and pathophysiologic relevance of an autopsy-confirmed Alzheimer's disease peripheral biomarker.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Khan TK,Alkon DL</div> <div itemprop="description">MN1020 was used in immunohistochemistry to evaluate an approach for the early diagnostic of Alzheimer disease</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20410196"> <div itemprop="name">Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice.</div> </a> <div itemprop="about">Endocrinology</div> <div itemprop="author">Carroll JC,Rosario ER,Villamagna A,Pike CJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry to determine the effects of continuous and cyclic P4 treatments on levels of tau hyperphosphorylation</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20592261"> <div itemprop="name">Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogaster.</div> </a> <div itemprop="about">Genetics</div> <div itemprop="author">Ambegaokar SS,Jackson GR</div> <div itemprop="description">MN1020 was used in western blot to study the interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila</div> <div itemprodp="datePublished">Wed Sep 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20157251"> <div itemprop="name">Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Liu XA,Liao K,Liu R,Wang HH,Zhang Y,Zhang Q,Wang Q,Li HL,Tian Q,Wang JZ</div> <div itemprop="description">MN1020 was used in western blot to study the mechanism by which tau dephosphorylation facilitates apoptosis</div> <div itemprodp="datePublished">Wed May 05 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20308782"> <div itemprop="name">Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Greco SJ,Bryan KJ,Sarkar S,Zhu X,Smith MA,Ashford JW,Johnston JM,Tezapsidis N,Casadesus G</div> <div itemprop="description">MN1020 was used in western blot to investigate the effect of leptin treatment on histopathology and memory capability in Alzheimer disease model</div> <div itemprodp="datePublished">Thu Jul 22 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20555131"> <div itemprop="name">Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Parachikova A,Vasilevko V,Cribbs DH,LaFerla FM,Green KN</div> <div itemprop="description">MN1020 was used in western blot to investigate the effect of minocycline on endogenous neuroinflammation and tau modification in Alzheimer disease mouse model</div> <div itemprodp="datePublished">Mon Dec 20 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20930277"> <div itemprop="name">Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Chen X,Wagener JF,Morgan DH,Hui L,Ghribi O,Geiger JD</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the role of elevated cholesterol ingestion on the pathology of Alzheimer's disease.</div> <div itemprodp="datePublished">Wed May 25 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20213269"> <div itemprop="name">Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau.</div> </a> <div itemprop="about">Brain structure & function</div> <div itemprop="author">Dickstein DL,Brautigam H,Stockton SD,Schmeidler J,Hof PR</div> <div itemprop="description">MN1020 was used in immunocytochemistry to investigate the alterations in dendrites and spines in the transgenic mice with human wild-type tau</div> <div itemprodp="datePublished">Mon Mar 01 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19850110"> <div itemprop="name">Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease.</div> </a> <div itemprop="about">Neuroscience</div> <div itemprop="author">Lecanu L,Rammouz G,McCourty A,Sidahmed EK,Greeson J,Papadopoulos V</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the effect of caprospinol on amyloid deposits and cognitive function in a rodent Alzheimer disease model</div> <div itemprodp="datePublished">Wed Jan 20 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20497908"> <div itemprop="name">Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease.</div> </a> <div itemprop="about">Neuroscience</div> <div itemprop="author">Morawski M,Brückner G,Jäger C,Seeger G,Arendt T</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the effect of aggrecan-based extracellular matrix on neuroprotection in Alzheimer disease</div> <div itemprodp="datePublished">Wed Sep 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20394726"> <div itemprop="name">The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons.</div> </a> <div itemprop="about">Neuroscience</div> <div itemprop="author">Bertrand J,Plouffe V,Sénéchal P,Leclerc N</div> <div itemprop="description">MN1020 was used in western blot to study the relationship between Tau phosphorylation pattern and neurodegenerative diseases</div> <div itemprodp="datePublished">Wed Jun 30 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20092557"> <div itemprop="name">In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles.</div> </a> <div itemprop="about">The European journal of neuroscience</div> <div itemprop="author">Härtig W,Kacza J,Paulke BR,Grosche J,Bauer U,Hoffmann A,Elsinghorst PW,Gütschow M</div> <div itemprop="description">MN1020 was used in immunohistochemistry to evaluate nanoparticles as carriers of AChE inhibitors for the treatment of Alzheimer disease</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20807511"> <div itemprop="name">Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways.</div> </a> <div itemprop="about">Brain research</div> <div itemprop="author">Rosario ER,Carroll J,Pike CJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the mechanism for the testosterone effect on Alzheimer disease-related pathology</div> <div itemprodp="datePublished">Thu Nov 04 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20677372"> <div itemprop="name">Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models.</div> </a> <div itemprop="about">Brain research</div> <div itemprop="author">Nicholson RM,Kusne Y,Nowak LA,LaFerla FM,Reiman EM,Valla J</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study areas of common vulnerability in different mouse models of Alzheimer's disease</div> <div itemprodp="datePublished">Fri Aug 06 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20460118"> <div itemprop="name">Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains.</div> </a> <div itemprop="about">Brain research</div> <div itemprop="author">Feuillette S,Deramecourt V,Laquerriere A,Duyckaerts C,Delisle MB,Maurage CA,Blum D,Buée L,Frébourg T,Campion D,Lecourtois M</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the colocalization of filamin-A and myosin VI with fibrillary tau protein in neurodegenerative diseases</div> <div itemprodp="datePublished">Fri Jul 23 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20304032"> <div itemprop="name">Acute hypoxia promote the phosphorylation of tau via ERK pathway.</div> </a> <div itemprop="about">Neuroscience letters</div> <div itemprop="author">Fang H,Zhang LF,Meng FT,Du X,Zhou JN</div> <div itemprop="description">MN1020 was used in western blot to study the role of the ERK pathway in hypoxia induced phosphorylation of tau</div> <div itemprodp="datePublished">Mon May 03 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20374499"> <div itemprop="name">Widespread distribution of reticulon-3 in various neurodegenerative diseases.</div> </a> <div itemprop="about">Neuropathology : official journal of the Japanese Society of Neuropathology</div> <div itemprop="author">Heath JE,Siedlak SL,Zhu X,Lee HG,Thakur A,Yan R,Perry G,Smith MA,Castellani RJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the distribution of membrane bound Reticulon proteins in neurodegenerative diseases</div> <div itemprodp="datePublished">Wed Dec 01 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20976192"> <div itemprop="name">Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Kakefuda K,Oyagi A,Ishisaka M,Tsuruma K,Shimazawa M,Yokota K,Shirai Y,Horie K,Saito N,Takeda J,Hara H</div> <div itemprop="description">MN1020 was used in western blot to investigate the role of diacylglycerol kinase beta in behavioral changes</div> <div itemprodp="datePublished">Mon Oct 18 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20720012"> <div itemprop="name">A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Zheng YL,Amin ND,Hu YF,Rudrabhatla P,Shukla V,Kanungo J,Kesavapany S,Grant P,Albers W,Pant HC</div> <div itemprop="description">MN1020 was used in western blot to investigate the effect of a p35 fragment on Cdk5-p25 activity and tau hyperphosphorylation</div> <div itemprodp="datePublished">Fri Oct 29 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20098733"> <div itemprop="name">Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Pan-Montojo F,Anichtchik O,Dening Y,Knels L,Pursche S,Jung R,Jackson S,Gille G,Spillantini MG,Reichmann H,Funk RH</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the ability of the pesticide and mitochondrial respiratory chain inhibitor rotenone to reproduce Parkinson's disease pathology in the mouse</div> <div itemprodp="datePublished">Tue Jan 19 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20631843"> <div itemprop="name">Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients.</div> </a> <div itemprop="about">Frontiers in neuroanatomy</div> <div itemprop="author">Blazquez-Llorca L,Garcia-Marin V,Defelipe J</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to observe the distribution of PHF-tau protein filaments and study its effect on synaptic connectivity in Alzheimer's patients.</div> <div itemprodp="datePublished">Thu Jul 14 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20664788"> <div itemprop="name">Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.</div> </a> <div itemprop="about">PLoS genetics</div> <div itemprop="author">Khurana V,Elson-Schwab I,Fulga TA,Sharp KA,Loewen CA,Mulkearns E,Tyynelä J,Scherzer CR,Feany MB</div> <div itemprop="description">MN1020 was used in western blot to investigate the role of lysosomal dysfunction in tau cleavage and neurotoxicity in vivo</div> <div itemprodp="datePublished">Thu Jul 15 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20431539"> <div itemprop="name">Efficient imaging of amyloid deposits in Drosophila models of human amyloidoses.</div> </a> <div itemprop="about">Nature protocols</div> <div itemprop="author">Berg I,Nilsson KP,Thor S,Hammarström P</div> <div itemprop="description">MN1020 was used in immunohistochemistry to describe a way to image amyloid deposits in the Drosophila brain</div> <div itemprodp="datePublished">Sat May 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20126313"> <div itemprop="name">A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Sharma A,Callahan LM,Sul JY,Kim TK,Barrett L,Kim M,Powers JM,Federoff H,Eberwine J</div> <div itemprop="description">MN1020 was used in immunohistochemistry to characterize Elk-1 as a link between symptoms of neurodegenerative diseases</div> <div itemprodp="datePublished">Tue Feb 02 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20920207"> <div itemprop="name">Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Minami SS,Sidahmed E,Aid S,Shimoji M,Niikura T,Mocchetti I,Rebeck GW,Prendergast JS,Dealwis C,Wetzel R,Bosetti F,Matsuoka Y,Hoe HS,Turner RS</div> <div itemprop="description">MN1020 was used in western blot to investigate the benefit vs. adverse effect of passive immunization in an Alzheimer disease model</div> <div itemprodp="datePublished">Tue Sep 28 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20595388"> <div itemprop="name">Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Liang B,Duan BY,Zhou XP,Gong JX,Luo ZG</div> <div itemprop="description">MN1020 was used in western blot to elucidate the mechanism of calpain during Alzheimer's disease progression</div> <div itemprodp="datePublished">Fri Sep 03 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21103384"> <div itemprop="name">Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Bittner T,Fuhrmann M,Burgold S,Ochs SM,Hoffmann N,Mitteregger G,Kretzschmar H,LaFerla FM,Herms J</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the dendritic spine loss during the progression of Alzheimer disease in a mouse model</div> <div itemprodp="datePublished">Tue Nov 16 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19557423"> <div itemprop="name">p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Nogalska A,Terracciano C,D'Agostino C,King Engel W,Askanas V</div> <div itemprop="description">MN1020 was used in immunocytochemistry to investigate the distribution of p62 in sporadic inclusion-body myositis muscle fibers and its application as a biomarker</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19283396"> <div itemprop="name">TDP-43 pathology in familial British dementia.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Schwab C,Arai T,Hasegawa M,Akiyama H,Yu S,McGeer PL</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the TDP-43 pathological inclusions in familial British dementia</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19321462"> <div itemprop="name">Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Lace G,Savva GM,Forster G,de Silva R,Brayne C,Matthews FE,Barclay JJ,Dakin L,Ince PG,Wharton SB</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the role of hippocampal tau stages in the diagnosis of cognitive impairment</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19526588"> <div itemprop="name">Bell's palsy preceding Parkinson's disease: a case-control study.</div> </a> <div itemprop="about">Movement disorders : official journal of the Movement Disorder Society</div> <div itemprop="author">Savica R,Bower JH,Maraganore DM,Grossardt BR,Rocca WA</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the Bell palsy in Parkinson disease</div> <div itemprodp="datePublished">Thu Jul 30 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19489077"> <div itemprop="name">Tremor on smiling.</div> </a> <div itemprop="about">Movement disorders : official journal of the Movement Disorder Society</div> <div itemprop="author">Schwingenschuh P,Cordivari C,Czerny J,Esposito M,Bhatia KP</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to describe two patients with bilateral facial tremors, with a high frequency of 9 Hz, which occurred on smiling and other activation of therisorii muscles.</div> <div itemprodp="datePublished">Thu Jul 30 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19526568"> <div itemprop="name">No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism.</div> </a> <div itemprop="about">Movement disorders : official journal of the Movement Disorder Society</div> <div itemprop="author">Halliday G,Herrero MT,Murphy K,McCann H,Ros-Bernal F,Barcia C,Mori H,Blesa FJ,Obeso JA</div> <div itemprop="description">MN1020 was used in immunohistochemistry to examine the effect of MPTP-induced oxidative stress and inflammation per se on Lewy body formation</div> <div itemprodp="datePublished">Thu Jul 30 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19609911"> <div itemprop="name">TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea.</div> </a> <div itemprop="about">Movement disorders : official journal of the Movement Disorder Society</div> <div itemprop="author">Kovacs GG,Murrell JR,Horvath S,Haraszti L,Majtenyi K,Molnar MJ,Budka H,Ghetti B,Spina S</div> <div itemprop="description">MN1020 was used in immunohistochemistry to report on a case of TARDBP variation associated with non-ALS neurodegeneration</div> <div itemprodp="datePublished">Tue Sep 15 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19513999"> <div itemprop="name">Parkinsonism in Gaucher's disease type 1: ten new cases and a review of the literature.</div> </a> <div itemprop="about">Movement disorders : official journal of the Movement Disorder Society</div> <div itemprop="author">Kraoua I,Stirnemann J,Ribeiro MJ,Rouaud T,Verin M,Annic A,Rose C,Defebvre L,Réménieras L,Schüpbach M,Belmatoug N,Vidailhet M,Sedel F</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to examine the prevalence of Parkinsonism in patients with Gaucher's disease.</div> <div itemprodp="datePublished">Thu Jul 30 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19145227"> <div itemprop="name">Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model.</div> </a> <div itemprop="about">Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology</div> <div itemprop="author">Ricobaraza A,Cuadrado-Tejedor M,Pérez-Mediavilla A,Frechilla D,Del Río J,García-Osta A</div> <div itemprop="description">MN1020 was used in western blot to investigate the effect of phenylbutyrate on neurocognitive function and taupathy in Alzheimer disease murine model</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18673368"> <div itemprop="name">Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain.</div> </a> <div itemprop="about">Brain pathology (Zurich, Switzerland)</div> <div itemprop="author">Wilhelmus MM,Grunberg SC,Bol JG,van Dam AM,Hoozemans JJ,Rozemuller AJ,Drukarch B</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the role of transglutaminases and transglutaminase-catalyzed cross-links in Alzheimer's disease pathology</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18410407"> <div itemprop="name">Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2.</div> </a> <div itemprop="about">Brain pathology (Zurich, Switzerland)</div> <div itemprop="author">Vidal R,Barbeito AG,Miravalle L,Ghetti B</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the neuropathological features in a transgenic mouse model of familial Danish dementia</div> <div itemprodp="datePublished">Thu Jan 01 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19101570"> <div itemprop="name">Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation.</div> </a> <div itemprop="about">Life sciences</div> <div itemprop="author">Sul D,Kim HS,Lee D,Joo SS,Hwang KW,Park SY</div> <div itemprop="description">MN1020 was used in western blot to investigate the potential neuroprotective effects of caffeic acid against Abeta-induced toxicity</div> <div itemprodp="datePublished">Fri Feb 27 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19279139"> <div itemprop="name">Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia.</div> </a> <div itemprop="about">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</div> <div itemprop="author">Planel E,Bretteville A,Liu L,Virag L,Du AL,Yu WH,Dickson DW,Whittington RA,Duff KE</div> <div itemprop="description">MN1020 was used in western blot to investigate the neurofibrillary pathology in a mouse model of tauopathy</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19893051"> <div itemprop="name">Brain-specific deletion of extracellular signal-regulated kinase 2 mitogen-activated protein kinase leads to aberrant cortical collagen deposition.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Heffron DS,Landreth GE,Samuels IS,Mandell JW</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to investigate neural-specific functions of extracellular signal-regulated kinase 2 in the murine brain.</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19453301"> <div itemprop="name">Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.</div> </a> <div itemprop="about">Journal of neurochemistry</div> <div itemprop="author">Kasher PR,De Vos KJ,Wharton SB,Manser C,Bennett EJ,Bingley M,Wood JD,Milner R,McDermott CJ,Miller CC,Shaw PJ,Grierson AJ</div> <div itemprop="description">MN1020 was used in immunocytochemistry to investigate the effect of spastin mutation on the defective axonal transport in the pathogenesis of hereditary spastic paraplegia</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18930955"> <div itemprop="name">Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Chatterjee S,Sang TK,Lawless GM,Jackson GR</div> <div itemprop="description">MN1020 was used in Western Blot to suggest that, in addition to tau phosphorylation, microtubule binding plays a crucial role in the regulation of tau toxicity when misexpressed.</div> <div itemprodp="datePublished">Thu Jan 01 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19617633"> <div itemprop="name">Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Tang J,LeGros RP,Louneva N,Yeh L,Cohen JW,Hahn CG,Blake DJ,Arnold SE,Talbot K</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study isoform-specific Dysbindin-1 decreases in the dorsolateral prefrontal cortex in schizophrenia</div> <div itemprodp="datePublished">Thu Oct 15 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18996433"> <div itemprop="name">2,3,7,8-TCDD neurotoxicity in neuroblastoma cells is caused by increased oxidative stress, intracellular calcium levels, and tau phosphorylation.</div> </a> <div itemprop="about">Toxicology</div> <div itemprop="author">Sul D,Kim HS,Cho EK,Lee M,Kim HS,Jung WW,Hwang KW,Park SY</div> <div itemprop="description">MN1020 was used in western blot to investigate the neurotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin</div> <div itemprodp="datePublished">Thu Jan 08 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19749435"> <div itemprop="name">Pathological-like assembly of tau induced by a paired helical filament core expressed at the plasma membrane.</div> </a> <div itemprop="about">Journal of Alzheimer's disease : JAD</div> <div itemprop="author">Campos-Peña V,Tapia-Ramírez J,Sánchez-Torres C,Meraz-Rios MA</div> <div itemprop="description">MN1020 was used in immunocytochemistry to study the generation of pathological-like tau assemblies at the plasma membrane</div> <div itemprodp="datePublished">Thu Sep 16 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19527721"> <div itemprop="name">Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains.</div> </a> <div itemprop="about">FEBS letters</div> <div itemprop="author">Sasaki K,Shimura H,Itaya M,Tanaka R,Mori H,Mizuno Y,Kosik KS,Tanaka S,Hattori N</div> <div itemprop="description">MN1020 was used in immunohistochemistry to show the association of excitatory amino acid transporter 2 with phosphorylated tau and its localization in neurofibrillary tangles</div> <div itemprodp="datePublished">Tue Jul 07 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19788916"> <div itemprop="name">Phospholipids block nuclear factor-kappa B and tau phosphorylation and inhibit amyloid-beta secretion in human neuroblastoma cells.</div> </a> <div itemprop="about">Neuroscience</div> <div itemprop="author">Pandey NR,Sultan K,Twomey E,Sparks DL</div> <div itemprop="description">MN1020 was used in western blot to study the effect of phospholipids on NF-kappa-B and Tau phosphorylation in human neuroblastoma cells</div> <div itemprodp="datePublished">Tue Dec 29 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19026996"> <div itemprop="name">The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival.</div> </a> <div itemprop="about">Brain research</div> <div itemprop="author">Lee HG,Zhu X,Casadesus G,Pallàs M,Camins A,O'Neill MJ,Nakanishi S,Perry G,Smith MA</div> <div itemprop="description">MN1020 was used in western blot to study the role of mGluR2 in the activation of ERK pathways and neuronal cell survival</div> <div itemprodp="datePublished">Fri Jan 16 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19166821"> <div itemprop="name">Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells.</div> </a> <div itemprop="about">Biochemical and biophysical research communications</div> <div itemprop="author">Greco SJ,Sarkar S,Johnston JM,Tezapsidis N</div> <div itemprop="description">MN1020 was used in western blot to study the regulation of tau phosphorylation and amyloid by leptin in neuronal cells.</div> <div itemprodp="datePublished">Fri Feb 27 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19429119"> <div itemprop="name">Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells.</div> </a> <div itemprop="about">Neuroscience letters</div> <div itemprop="author">Greco SJ,Sarkar S,Casadesus G,Zhu X,Smith MA,Ashford JW,Johnston JM,Tezapsidis N</div> <div itemprop="description">MN1020 was used in western blot to study the role of GSK-3beta in mediating the effectsof leptin on tau phosphorylation in neuronal cells</div> <div itemprodp="datePublished">Fri May 22 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19584523"> <div itemprop="name">Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation.</div> </a> <div itemprop="about">Bioscience, biotechnology, and biochemistry</div> <div itemprop="author">Kim HS,Sul D,Lim JY,Lee D,Joo SS,Hwang KW,Park SY</div> <div itemprop="description">MN1020 was used in western blot to assess the neuroprotective effects of delphinidin against Abeta-induced toxicity</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19946466"> <div itemprop="name">Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease.</div> </a> <div itemprop="about">Aging</div> <div itemprop="author">Bonda DJ,Evans TA,Santocanale C,Llosá JC,Viña J,Bajic V,Castellani RJ,Siedlak SL,Perry G,Smith MA,Lee HG</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study aberrant cell cycle progression and abnormal subcellular localization of phosphorylated Mcm2 in Alzheimer's disease and the significance for neronal degeneration</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19700815"> <div itemprop="name">Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration.</div> </a> <div itemprop="about">Journal of neural engineering</div> <div itemprop="author">McConnell GC,Rees HD,Levey AI,Gutekunst CA,Gross RE,Bellamkonda RV</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the inflammatory and neurodegenerative effects caused by implanted neural electrodes</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18936941"> <div itemprop="name">LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Huang Y,Song YJ,Murphy K,Holton JL,Lashley T,Revesz T,Gai WP,Halliday GM</div> <div itemprop="description">MN1020 was used in immunohistochemistry to determine whether LRRK2 and parkin associate with glial cytoplasmic inclusions</div> <div itemprodp="datePublished">Mon Dec 01 00:00:00 EST 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18066559"> <div itemprop="name">MAPT S305I mutation: implications for argyrophilic grain disease.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Kovacs GG,Pittman A,Revesz T,Luk C,Lees A,Kiss E,Tariska P,Laszlo L,Molnár K,Molnar MJ,Tolnay M,de Silva R</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the role of MAPT mutation in argyrophilic grain disease.</div> <div itemprodp="datePublished">Tue Jul 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19091971"> <div itemprop="name">Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Liu Y,Yoo MJ,Savonenko A,Stirling W,Price DL,Borchelt DR,Mamounas L,Lyons WE,Blue ME,Lee MK</div> <div itemprop="description">MN1020 was used in immunocytochemistry to investigate the pathology of MAergic neurons in an Alzheimer disease mouse model</div> <div itemprodp="datePublished">Wed Dec 17 00:00:00 EST 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19036972"> <div itemprop="name">Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Planel E,Krishnamurthy P,Miyasaka T,Liu L,Herman M,Kumar A,Bretteville A,Figueroa HY,Yu WH,Whittington RA,Davies P,Takashima A,Nixon RA,Duff KE</div> <div itemprop="description">MN1020 was used in western blot to investigate the effect of anesthesia-induced hyperphosphorylation on the detachment of 3-repeat Tau and Tau stability</div> <div itemprodp="datePublished">Wed Nov 26 00:00:00 EST 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18573304"> <div itemprop="name">Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation.</div> </a> <div itemprop="about">Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association</div> <div itemprop="author">Park SY,Kim HS,Cho EK,Kwon BY,Phark S,Hwang KW,Sul D</div> <div itemprop="description">MN1020 was used in western blot to elucidate the neuroprotective mechanisms by which curcumin protects against Abeta-induced toxicity</div> <div itemprodp="datePublished">Fri Aug 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18662245"> <div itemprop="name">The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins.</div> </a> <div itemprop="about">Journal of neurochemistry</div> <div itemprop="author">Kanungo J,Zheng YL,Amin ND,Pant HC</div> <div itemprop="description">MN1020 was used in immunocytochemistry and western blot to elucidate the relationship between Notch and cdk5 signaling.</div> <div itemprodp="datePublished">Mon Sep 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18485099"> <div itemprop="name">Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells.</div> </a> <div itemprop="about">Journal of neurochemistry</div> <div itemprop="author">Hu M,Waring JF,Gopalakrishnan M,Li J</div> <div itemprop="description">MN1020 was used in western blot to investigate the role of tau phosphorylation in PC12 cells</div> <div itemprodp="datePublished">Fri Aug 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18000817"> <div itemprop="name">Hippocampus of Ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels.</div> </a> <div itemprop="about">Hippocampus</div> <div itemprop="author">Schrag M,Sharma S,Brown-Borg H,Ghribi O</div> <div itemprop="description">MN1020 was used in immunohistochemistry to examine the resistance of Ames dwarf mice towards the beta-amyloid-induced neurotoxicities</div> <div itemprodp="datePublished">Thu Mar 27 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18606155"> <div itemprop="name">CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice.</div> </a> <div itemprop="about">Brain research</div> <div itemprop="author">Laporte V,Ait-Ghezala G,Volmar CH,Ganey C,Ganey N,Wood M,Mullan M</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the role of CD40 ligation in plaque-associated tau phosphorylation in beta-amyloid overproducing mice</div> <div itemprodp="datePublished">Mon Sep 22 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18755042"> <div itemprop="name">Pedigree with frontotemporal lobar degeneration--motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9.</div> </a> <div itemprop="about">BMC neurology</div> <div itemprop="author">Luty AA,Kwok JB,Thompson EM,Blumbergs P,Brooks WS,Loy CT,Dobson-Stone C,Panegyres PK,Hecker J,Nicholson GA,Halliday GM,Schofield PR</div> <div itemprop="description">MN1020 was used in immunohistochemistry to identify the gene loci for the frontotemporal lobar degeneration--motor neuron disease and Tar DNA binding protein-43 positive neuropathology</div> <div itemprodp="datePublished">Fri Aug 29 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18583940"> <div itemprop="name">A new function of microtubule-associated protein tau: involvement in chromosome stability.</div> </a> <div itemprop="about">Cell cycle (Georgetown, Tex.)</div> <div itemprop="author">Rossi G,Dalprà L,Crosti F,Lissoni S,Sciacca FL,Catania M,Di Fede G,Mangieri M,Giaccone G,Croci D,Tagliavini F</div> <div itemprop="description">MN1020 was used in immunocytochemistry to study a potential role of tau in chromosome stability via its interaction with chromatin and microtubules</div> <div itemprodp="datePublished">Sun Jun 15 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18710535"> <div itemprop="name">Brain region-specificity of palmitic acid-induced abnormalities associated with Alzheimer's disease.</div> </a> <div itemprop="about">BMC research notes</div> <div itemprop="author">Patil S,Balu D,Melrose J,Chan C</div> <div itemprop="description">MN1020 was used in western blot to investigate the relationship between brain region-specific free fatty acid metabolism and region-specific brain damage observed in Alzheimer disease</div> <div itemprodp="datePublished">Wed Jun 04 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17442823"> <div itemprop="name">Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Green KN,Martinez-Coria H,Khashwji H,Hall EB,Yurko-Mauro KA,Ellis L,LaFerla FM</div> <div itemprop="description">MN1020 was used in western blot to show steady-state levels of phospho-tau epitopes from 9 month PUFA-treated transgenic mouse model that exhibits both A Beta and tau pathologies.</div> <div itemprodp="datePublished">Wed Apr 18 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17376970"> <div itemprop="name">Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Planel E,Richter KE,Nolan CE,Finley JE,Liu L,Wen Y,Krishnamurthy P,Herman M,Wang L,Schachter JB,Nelson RB,Lau LF,Duff KE</div> <div itemprop="description">MN1020 was used in immunohistochemistry to examine the effect of anesthesia on tau hyperphosphorylation</div> <div itemprodp="datePublished">Wed Mar 21 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18045930"> <div itemprop="name">Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Carroll JC,Rosario ER,Chang L,Stanczyk FZ,Oddo S,LaFerla FM,Pike CJ</div> <div itemprop="description">MN1020 was used in immunohistochemistry to examine the individual and combined effects of estrogen and progesterone on beta-amyloid accumulation, tau hyperphosphorylation, and hippocampal-dependent behavioral impairments</div> <div itemprodp="datePublished">Wed Nov 28 00:00:00 EST 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17567816"> <div itemprop="name">Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Rissman RA,Lee KF,Vale W,Sawchenko PE</div> <div itemprop="description">MN1020 was used in western blot to investigate the influence of CRFR on tau modification under stress conditions</div> <div itemprodp="datePublished">Wed Jun 13 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17239015"> <div itemprop="name">Synucleinopathy with features of both multiple system atrophy and dementia with Lewy bodies.</div> </a> <div itemprop="about">Neuropathology and applied neurobiology</div> <div itemprop="author">Sikorska B,Papierz W,Preusser M,Liberski PP,Budka H</div> <div itemprop="description">MN1020 was used in immunohistochemistry to characterize a unique case of synucleinopathy with multiple system atrophy and dementia</div> <div itemprodp="datePublished">Thu Feb 01 00:00:00 EST 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17298384"> <div itemprop="name">Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-beta-induced cell death.</div> </a> <div itemprop="about">Journal of neurochemistry</div> <div itemprop="author">Leschik J,Welzel A,Weissmann C,Eckert A,Brandt R</div> <div itemprop="description">MN1020 was used in western blot to investigate the regulatory effect of presenilin 1 and amyloid-beta on tau-dependent neurodegeneration</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16962365"> <div itemprop="name">Insular pathology in Parkinson's disease patients with orthostatic hypotension.</div> </a> <div itemprop="about">Parkinsonism & related disorders</div> <div itemprop="author">Papapetropoulos S,Mash DC</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the association between the severity of insular cortex pathology in Parkinson's disease and the occurrence orthostatic hypotension</div> <div itemprodp="datePublished">Sun Jul 01 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17146589"> <div itemprop="name">Motor fluctuations and dyskinesias in advanced/end stage Parkinson's disease: a study from a population of brain donors.</div> </a> <div itemprop="about">Journal of neural transmission (Vienna, Austria : 1996)</div> <div itemprop="author">Papapetropoulos S,Mash DC</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the prevalence of motor fluctuations and dyskinesias in end stage patients with Parkinson disease</div> <div itemprodp="datePublished">Thu Mar 01 00:00:00 EST 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17188332"> <div itemprop="name">Increased expression of the Nogo receptor in the hippocampus and its relation to the neuropathology in Alzheimer's disease.</div> </a> <div itemprop="about">Human pathology</div> <div itemprop="author">Zhu HY,Guo HF,Hou HL,Liu YJ,Sheng SL,Zhou JN</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the increased expression of NgR in hippocampus and its role in Alzheimer Disease neuropathology</div> <div itemprodp="datePublished">Thu Mar 01 00:00:00 EST 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17408857"> <div itemprop="name">Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias.</div> </a> <div itemprop="about">Neuroscience letters</div> <div itemprop="author">Magaki S,Raghavan R,Mueller C,Oberg KC,Vinters HV,Kirsch WM</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the role of iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias</div> <div itemprodp="datePublished">Fri May 11 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17549012"> <div itemprop="name">Autophagocytosis of mitochondria is prominent in Alzheimer disease.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Moreira PI,Siedlak SL,Wang X,Santos MS,Oliveira CR,Tabaton M,Nunomura A,Szweda LI,Aliev G,Smith MA,Zhu X,Perry G</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the autophagocytosis of mitochondria in Alzheimer disease</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16930897"> <div itemprop="name">Autopsy at 2 months after death: brain is satisfactorily preserved for neuropathology.</div> </a> <div itemprop="about">Forensic science international</div> <div itemprop="author">Gelpi E,Preusser M,Bauer G,Budka H</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study neuropathological features of a brain fixed 2 months after death</div> <div itemprodp="datePublished">Thu May 24 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18098043"> <div itemprop="name">Expression of serine/threonine protein-kinases and related factors in normal monkey and human retinas: the mechanistic understanding of a CDK2 inhibitor induced retinal toxicity.</div> </a> <div itemprop="about">Toxicologic pathology</div> <div itemprop="author">Saturno G,Pesenti M,Cavazzoli C,Rossi A,Giusti AM,Gierke B,Pawlak M,Venturi M</div> <div itemprop="description">MN1020 was used in Immunohistochemistry to demonstrate how complementary gene expression and protein-based technologies can be used to understand the molecular mechanism of a cyclin dependent protein-kinase 2 inhibitor induced toxicity.</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16171999"> <div itemprop="name">A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice.</div> </a> <div itemprop="about">Neurobiology of disease</div> <div itemprop="author">Blain JF,Sullivan PM,Poirier J</div> <div itemprop="description">MN1020 was used in western blot to investigate the effect of apoE4 on astroglial repair process and synaptic remodeling</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16998902"> <div itemprop="name">Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?</div> </a> <div itemprop="about">Journal of neuroscience research</div> <div itemprop="author">Lee HG,Ueda M,Zhu X,Perry G,Smith MA</div> <div itemprop="description">MN1020 was used in immunocytochemistry to investigate the alteration of transforming growth factor-beta pathway in Alzheimer disease</div> <div itemprodp="datePublished">Fri Dec 01 00:00:00 EST 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16772869"> <div itemprop="name">Formation of phospho-SAPK/JNK granules in the hippocampus is an early event in Alzheimer disease.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Lagalwar S,Guillozet-Bongaarts AL,Berry RW,Binder LI</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the formation of p-SAPK/JNK in hippocampus during the early stages of Alzheimer disease</div> <div itemprodp="datePublished">Mon May 01 00:00:00 EDT 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17046656"> <div itemprop="name">X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease.</div> </a> <div itemprop="about">Methods in enzymology</div> <div itemprop="author">Ikonomovic MD,Abrahamson EE,Isanski BA,Debnath ML,Mathis CA,Dekosky ST,Klunk WE</div> <div itemprop="description">MN1020 was used in immunohistochemistry to describe methods for the fluorescent labeling of abnormal protein aggregates in Alzheimer's disease</div> <div itemprodp="datePublished">Tue Nov 14 00:00:00 EST 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16178030"> <div itemprop="name">A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy.</div> </a> <div itemprop="about">Annals of neurology</div> <div itemprop="author">Obici L,Demarchi A,de Rosa G,Bellotti V,Marciano S,Donadei S,Arbustini E,Palladini G,Diegoli M,Genovese E,Ferrari G,Coverlizza S,Merlini G</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the association between a APP mutation and cerebral amyloid angiopathy.</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2005</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16035099"> <div itemprop="name">Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease.</div> </a> <div itemprop="about">Movement disorders : official journal of the Movement Disorder Society</div> <div itemprop="author">Klos KJ,Josephs KA,Parisi JE,Dickson DW</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the clinicopathological features of co-occurring idiopathic Parkinson disease and motor neuron disease</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EST 2005</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/15621017"> <div itemprop="name">The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology.</div> </a> <div itemprop="about">Brain research</div> <div itemprop="author">Wang YJ,Chen GH,Hu XY,Lu YP,Zhou JN,Liu RY</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the expression of CaMKII-alpha in hippocampus and its role in Alzheimer disease neuropathology</div> <div itemprodp="datePublished">Fri Jan 07 00:00:00 EST 2005</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/15715081"> <div itemprop="name">Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Hung KS,Hwang SL,Liang CL,Chen YJ,Lee TH,Liu JK,Howng SL,Wang CH</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the influence of calpain inhibition on spinal cord hemisection treatment</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2005</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/14872255"> <div itemprop="name">Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Lee HG,Ogawa O,Zhu X,O'Neill MJ,Petersen RB,Castellani RJ,Ghanbari H,Perry G,Smith MA</div> <div itemprop="description">MN1020 was used in immunocytochemistry to study the involvement of metabotropic glutamate receptor 2 in the pathogenesis of Alzheimer disease</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EST 2004</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/15282215"> <div itemprop="name">Astrocytic degeneration relates to the severity of disease in frontotemporal dementia.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Broe M,Kril J,Halliday GM</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate the relationship between astrocytic degeneration and frontotemporal dementia</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2004</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/15174015"> <div itemprop="name">Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum.</div> </a> <div itemprop="about">Annals of neurology</div> <div itemprop="author">Mesulam M,Shaw P,Mash D,Weintraub S</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study cholinergic nucleus basalis tauopathy at the early stage of neurodegeneration</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2004</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/15009685"> <div itemprop="name">Mutant superoxide dismutase 1 causes motor neuron degeneration independent of cyclin-dependent kinase 5 activation by p35 or p25.</div> </a> <div itemprop="about">Journal of neurochemistry</div> <div itemprop="author">Takahashi S,Kulkarni AB</div> <div itemprop="description">MN1020 was used in western blot to report that the pathogenesis of motor neuron disease is independent of the Cdk5 activation by p35 or p25.</div> <div itemprodp="datePublished">Mon Mar 01 00:00:00 EST 2004</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/15099026"> <div itemprop="name">Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene.</div> </a> <div itemprop="about">Journal of neuropathology and experimental neurology</div> <div itemprop="author">Vidal R,Ghetti B,Takao M,Brefel-Courbon C,Uro-Coste E,Glazier BS,Siani V,Benson MD,Calvas P,Miravalle L,Rascol O,Delisle MB</div> <div itemprop="description">MN1020 was used in immunohistochemistry to investigate ferritin accumulation in neurodegenerative diseases</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EST 2004</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/14963027"> <div itemprop="name">Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Shimura H,Miura-Shimura Y,Kosik KS</div> <div itemprop="description">MN1020 was used in western blot to investigate the influence of heat shock protein 27 interaction with tau on tau phosphorylation and cell survival</div> <div itemprodp="datePublished">Fri Apr 23 00:00:00 EDT 2004</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/12615642"> <div itemprop="name">Severity of gliosis in Pick's disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Schofield E,Kersaitis C,Shepherd CE,Kril JJ,Halliday GM</div> <div itemprop="description">MN1020 was used in immunocytochemistry to characterize the tau protein in Pick disease and frontotemporal lobar degeneration</div> <div itemprodp="datePublished">Tue Apr 01 00:00:00 EST 2003</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/12536148"> <div itemprop="name">Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Takahashi S,Saito T,Hisanaga S,Pant HC,Kulkarni AB</div> <div itemprop="description">MN1020 was used in western blot to report that tau is phosphorylated by Cdk5/p39 during brain development.</div> <div itemprodp="datePublished">Fri Mar 21 00:00:00 EST 2003</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/12551948"> <div itemprop="name">14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Agarwal-Mawal A,Qureshi HY,Cafferty PW,Yuan Z,Han D,Lin R,Paudel HK</div> <div itemprop="description">MN1020 was used in western blot to investigate the role of 14-3-3 in tau function in brain</div> <div itemprodp="datePublished">Fri Apr 11 00:00:00 EDT 2003</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/12012092"> <div itemprop="name">Ubiquitin-positive neuronal and tau 2-positive glial inclusions in frontotemporal dementia of motor neuron type.</div> </a> <div itemprop="about">Acta neuropathologica</div> <div itemprop="author">Forno LS,Langston JW,Herrick MK,Wilson JD,Murayama S</div> <div itemprop="description">MN1020 was used in immunohistochemistry (paraffin) to discuss classification of fronto-temporal dementias.</div> <div itemprodp="datePublished">Sat Jun 01 00:00:00 EDT 2002</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/12366820"> <div itemprop="name">The role of cytochrome c oxidase deficient hippocampal neurones in Alzheimer's disease.</div> </a> <div itemprop="about">Neuropathology and applied neurobiology</div> <div itemprop="author">Cottrell DA,Borthwick GM,Johnson MA,Ince PG,Turnbull DM</div> <div itemprop="description">MN1020 was used in immunohistochemistry to study the effect of cytochrome c oxidase deficiency in Alzheimer hippocampal neurons</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2002</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/11182476"> <div itemprop="name">Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age.</div> </a> <div itemprop="about">Neurobiology of aging</div> <div itemprop="author">Cottrell DA,Blakely EL,Johnson MA,Ince PG,Borthwick GM,Turnbull DM</div> <div itemprop="description">MN1020 was used in immunocytochemistry to study the role of age in cytochrome c oxidase deficient cells in the hippocampus and choroid plexus</div> <div itemprodp="datePublished">Thu May 03 00:00:00 EDT 2001</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/10617113"> <div itemprop="name">PD98059 prevents neurite degeneration induced by fibrillar beta-amyloid in mature hippocampal neurons.</div> </a> <div itemprop="about">Journal of neurochemistry</div> <div itemprop="author">Rapoport M,Ferreira A</div> <div itemprop="description">MN1020 was used in western blot to investigate the signal transduction pathway activated by fibrillar Abeta.</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2000</div> </div> </noscript> </div> <div class="border-bottom"></div> <div class="product-bioinformatics-details"> <div class="container"> <h2 class="pdp-sub-heading">Bioinformatics</h2> <div class="row"> <div class="large-span-6 medium-span-12 small-span-12"> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="proteinContent"> <strong>Protein Aliases:</strong> FLJ31424; FTDP17; G protein beta1/gamma2 subunit-interacting factor 1; map tau; MGC138549; Microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; microtubules; Neurofibrillary tangle protein; neurofibrillary tangles; Neuronal Marker; Paired helical filament-tau; PHF-tau; PHFtau; protein phosphatase 1, regulatory subunit 103; Tau-4; Tau5 </p> <p class="view-buttons" id="ptnViewBtn" ng-class="$ctrl.bioContentLines('proteinContent', 'ptnViewBtn')"> <a id="proteinViewMoreBtn" ng-click="$ctrl.bioContentViewMore('proteinViewMoreBtn', 'proteinViewLessBtn', 'proteinContent')"> View more </a> <a id="proteinViewLessBtn" ng-click="$ctrl.bioContentViewLess('proteinViewLessBtn', 'proteinViewMoreBtn', 'proteinContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="geneContent"> <strong>Gene Aliases:</strong> AI413597; AW045860; DDPAC; FTDP-17; MAPT; MAPTL; MSTD; Mtapt; MTBT1; MTBT2; PPND; PPP1R103; TAU </p> <p class="view-buttons" id="geneViewBtn" ng-class="$ctrl.bioContentLines('geneContent', 'geneViewBtn')"> <a id="geneViewMoreBtn" ng-click="$ctrl.bioContentViewMore('geneViewMoreBtn', 'geneViewLessBtn', 'geneContent')"> View more </a> <a id="geneViewLessBtn" ng-click="$ctrl.bioContentViewLess('geneViewLessBtn', 'geneViewMoreBtn', 'geneContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="unitProContent"> <strong>UniProt ID:</strong> <a href="http://www.uniprot.org/uniprot/P10636" target="_blank">(Human) P10636</a>, <a href="http://www.uniprot.org/uniprot/P10637" target="_blank">(Mouse) P10637</a> </p> <p class="view-buttons" id="unitViewBtn" ng-class="$ctrl.bioContentLines('unitProContent', 'unitViewBtn')"> <a id="unitProViewMoreBtn" ng-click="$ctrl.bioContentViewMore('unitProViewMoreBtn', 'unitProViewLessBtn', 'unitProContent')"> View more </a> <a id="unitProViewLessBtn" ng-click="$ctrl.bioContentViewLess('unitProViewLessBtn', 'unitProViewMoreBtn', 'unitProContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="entrezContent"> <strong>Entrez Gene ID:</strong> <a href="http://www.ncbi.nlm.nih.gov/gene?term=4137" target="_blank">(Human) 4137</a>, <a href="http://www.ncbi.nlm.nih.gov/gene?term=17762" target="_blank">(Mouse) 17762</a> </p> <p class="view-buttons" id="etzViewBtn" ng-class="$ctrl.bioContentLines('entrezContent', 'etzViewBtn')"> <a id="entrezViewMoreBtn" ng-click="$ctrl.bioContentViewMore('entrezViewMoreBtn', 'entrezViewLessBtn', 'entrezContent')"> View more </a> <a id="entrezViewLessBtn" ng-click="$ctrl.bioContentViewLess('entrezViewLessBtn', 'entrezViewMoreBtn', 'entrezContent')"> View less </a> </p> </div> </div> <div class="large-span-6 medium-span-12 small-span-12"> <div class="accordion" id="accordion-bioinformatics"> <div class="accordion-group"> <div class="accordion-heading"> <a class="accordion-toggle" data-toggle="collapse" data-parent="#accordion2" target="_self" href="#collapseOne"> Function(s) </a> </div> <div id="collapseOne" class="accordion-body collapse"> <div class="accordion-inner"> <a class="icon" href="/antibody/primary/panther/structural constituent of cytoskeleton"> structural constituent of cytoskeleton </a> <a class="icon" href="/antibody/primary/panther/protein binding"> protein binding </a> <a class="icon" href="/antibody/primary/panther/microtubule binding"> microtubule binding </a> <a class="icon" href="/antibody/primary/panther/SH3 domain binding"> SH3 domain binding </a> <a class="icon" href="/antibody/primary/panther/enzyme binding"> enzyme binding </a> <a class="icon" href="/antibody/primary/panther/protein kinase binding"> protein kinase binding </a> <a class="icon" href="/antibody/primary/panther/protein complex binding"> protein complex binding </a> <a class="icon" href="/antibody/primary/panther/apolipoprotein binding"> apolipoprotein binding </a> <a class="icon" href="/antibody/primary/panther/protein phosphatase 2A binding"> protein phosphatase 2A binding </a> <a class="icon" href="/antibody/primary/panther/lipoprotein particle binding"> lipoprotein particle binding </a> <a class="icon" href="/antibody/primary/panther/tubulin binding"> tubulin binding </a> <a class="icon" href="/antibody/primary/panther/protein domain specific binding"> protein domain specific binding </a> </div> </div> </div> <div class="accordion-group"> <div class="accordion-heading"> <a class="accordion-toggle" data-toggle="collapse" data-parent="#accordion2" target="_self" href="#collapseTwo"> Process(es) </a> </div> <div id="collapseTwo" class="accordion-body collapse"> <div class="accordion-inner"> <a class="icon" href="/antibody/primary/panther/microtubule cytoskeleton organization"> microtubule cytoskeleton organization </a> <a class="icon" href="/antibody/primary/panther/neuron migration"> neuron migration </a> <a class="icon" href="/antibody/primary/panther/brain development"> brain development </a> <a class="icon" href="/antibody/primary/panther/female pregnancy"> female pregnancy </a> <a class="icon" href="/antibody/primary/panther/response to nutrient"> response to nutrient </a> <a class="icon" href="/antibody/primary/panther/adult walking behavior"> adult walking behavior </a> <a class="icon" href="/antibody/primary/panther/axo-dendritic transport"> axo-dendritic transport </a> <a class="icon" href="/antibody/primary/panther/intrinsic apoptotic signaling pathway in response to oxidative stress"> intrinsic apoptotic signaling pathway in response to oxidative stress </a> <a class="icon" href="/antibody/primary/panther/response to organic substance"> response to organic substance </a> <a class="icon" href="/antibody/primary/panther/regulation of autophagy"> regulation of autophagy </a> <a class="icon" href="/antibody/primary/panther/regulation of microtubule polymerization"> regulation of microtubule polymerization </a> <a class="icon" href="/antibody/primary/panther/positive regulation of microtubule polymerization"> positive regulation of microtubule polymerization </a> <a class="icon" href="/antibody/primary/panther/negative regulation of intracellular transport"> negative regulation of intracellular transport </a> <a class="icon" href="/antibody/primary/panther/positive regulation of axon extension"> positive regulation of axon extension </a> <a class="icon" href="/antibody/primary/panther/mitochondrion transport along microtubule"> mitochondrion transport along microtubule </a> <a class="icon" href="/antibody/primary/panther/axon extension"> axon extension </a> <a class="icon" href="/antibody/primary/panther/generation of neurons"> generation of neurons </a> <a class="icon" href="/antibody/primary/panther/regulation of microtubule-based movement"> regulation of microtubule-based movement </a> <a class="icon" href="/antibody/primary/panther/apoptotic process"> apoptotic process </a> <a class="icon" href="/antibody/primary/panther/axonogenesis"> axonogenesis </a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="recommended-products border-bottom hidden">  It has to be done as per old AB suggested Products section. </div> <script type="text/javascript" src="/order/genome-database/assets/core/js/magellanCore.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript"> $m.addPerformanceMark('abPDPScripts:loadBegin'); </script> <script type="text/javascript" src="/order/genome-database/assets/js/shared-module/dist/angular108-document-scripts.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript" src="/order/genome-database/assets/js/shared-module/dist/pdp-combined-scripts.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript" src="/order/genome-database/assets/js/shared-module/dist/combined-vendor.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script defer type="text/javascript" src="/order/genome-database/assets/core/dist/angular/gallery-module/gallery-module.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript" src="/order/genome-database/assets/js/angular/dist/pdp/common.pdp.dist.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript" src="/order/genome-database/assets/js/angular/dist/pdp/antibody.pdp.dist.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script defer type="text/javascript" src="/order/genome-database/assets/js/shared-module/dist/pdp/template-cache-cmrc-card-antibody.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script defer type="text/javascript" src="/order/genome-database/assets/js/shared-module/dist/pdp/template-cache-hero.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script defer type="text/javascript" src="/order/genome-database/assets/js/shared-module/dist/pdp/template-cache-reference-section.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript"> $m.addPerformanceMark('abPDPScripts:loadEnd'); $m.addPerformanceMeasure('abPDPScripts:loadTime' , 'abPDPScripts:loadBegin', 'abPDPScripts:loadEnd'); </script> </div> <script> if (typeof window.$mangular === 'undefined' || !window.$mangular) { window.$mangular = {}; } window.$mangular.referenceCount = 911; window.$mangular.publishedFiguresCount = 0; window.$mangular.productId = 'MN1020'; window.$mangular.citationJson = {"citationApplications":[{"applicationAbbreviation":"WB","citations":[{"title":"Differences in Tau Seeding in Newborn and Adult Wild-Type Mice.","summary":"MN1020 was used in Western Blotting and Immunohistochemistry to show that (a) differences in tau seeding between newborn and young adults may be related to the ratios between 3Rtau and 4Rtau, and the shift to 4Rtau predominance in adults, together with the immaturity of connections in newborn mice, and (b) intracerebral inoculation of sAD PHFs in newborn mice does not protect from tau seeding following intracerebral inoculation of sAD PHFs in young/adult mice.","authors":"Ferrer I,Andrés-Benito P,Garcia-Esparcia P,López-Gonzalez I,Valiente D,Jordán-Pirla M,Carmona M,Sala-Jarque J,Gil V,Del Rio JA","literatureId":"35563179","journal":"International journal of molecular sciences","volume":"23","publishedDate":"Apr 26, 2022, 4:00:00 AM","url":"http://dx.doi.org/10.3390/ijms23094789","benchSci":false,"imageURL":"https://www.thermofisher.com/antibody/images/250/null?time\u003d20240507","journalAbbr":"Int J Mol Sci","sortOrder":116,"species":["Mouse"],"speciesDilutionMap":{"Mouse":"1:250"},"abbreviationToNameMap":{"IHC":"Immunohistochemistry","WB":"Western Blot"},"newSpeciesDilutionMap":{"Mouse~IHC~1:50":"1:50"}},{"title":"Overexpression of Kinesin Superfamily Motor Proteins in Alzheimer\u0027s Disease.","summary":"MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to conclude that upregulation of KIFs may be an adaptive response to impaired axonal transport in Alzheimer\u0027s disease (AD).","authors":"Hares K,Miners JS,Cook AJ,Rice C,Scolding N,Love S,Wilkins A","literatureId":"29060936","journal":"Journal of Alzheimer\u0027s disease : JAD","volume":"60","pageNumber":"1511","publishedDate":"Jul 23, 2018, 4:00:00 AM","url":"http://dx.doi.org/10.3233/JAD-170094","benchSci":false,"imageURL":"https://www.thermofisher.com/antibody/images/250/null?time\u003d20240507","journalAbbr":"J Alzheimers Dis","sortOrder":419,"species":["Human"],"speciesDilutionMap":{"Human":"1:500"},"abbreviationToNameMap":{"WB":"Western Blot"},"newSpeciesDilutionMap":{"Human~WB~1:500":"1:500"}},{"title":"RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation.","summary":"MN1020 was used in Western Blot to indicate that neuronal NSun2 deficiency promotes dysregulation of miR-125b and tau phosphorylation in AD and highlights a novel avenue for therapeutic targeting.","authors":"Kim YA,Siddiqui T,Blaze J,Cosacak MI,Winters T,Kumar A,Tein E,Sproul AA,Teich AF,Bartolini F,Akbarian S,Kizil C,Hargus G,Santa-Maria I","literatureId":"36357715","journal":"Acta neuropathologica","volume":"145","pageNumber":"29","publishedDate":"Jan 1, 2023, 5:00:00 AM","url":"http://dx.doi.org/10.1007/s00401-022-02511-7","benchSci":false,"imageURL":"https://www.thermofisher.com/antibody/images/250/null?time\u003d20240507","journalAbbr":"Acta Neuropathol","sortOrder":21,"species":["Human"],"speciesDilutionMap":{"Human":"1:500"},"abbreviationToNameMap":{"WB":"Western Blot"},"newSpeciesDilutionMap":{"Human~WB~1:500":"1:500"}}],"citationsCount":280,"speciesList":["Human","Fruit fly","C. elegans","Mouse","Rat","Non-human primate","Cat","Hamster"],"journals":["Life Sci","NPJ Vaccines","Brain","Front Aging Neurosci","Mol Med Rep","Front Cell Neurosci","Methods Mol Biol","Nat Commun","Biochem Biophys Res Commun","Dis Model Mech","Toxicology","Nat Neurosci","Nat Med","Neurobiol Dis","Alzheimers Dement","Am J Pathol","J Am Heart Assoc","Food Chem Toxicol","eNeuro","ACS Chem Neurosci","PLoS One","Neurotherapeutics","Adv Healthc Mater","J Clin Med","J Neurochem","J Neuroinflammation","Nat Struct Mol Biol","J Alzheimers Dis","Sci China Life Sci","Bioact Mater","Anesthesiology","Redox Biol","Neurosci Bull","Elife","PLoS Genet","Neurodegener Dis","Acta Biol Hung","Brain Res","Neurobiol Aging","Hum Mol Genet","J Neurosci","Brain Pathol","Biochim Biophys Acta","Aging Cell","iScience","Nature","Neural Plast","Br J Pharmacol","Front Behav Neurosci","Am J Alzheimers Dis Other Demen","Neural Regen Res","Biol Psychiatry","Neuron","Acta Neuropathol Commun","Proc Natl Acad Sci U S A","Commun Biol","Mol Psychiatry","Sci Adv","Front Cell Dev Biol","J Nutr Biochem","Front Mol Neurosci","Antioxidants (Basel)","Neuroscience","Neurosci Lett","Cell Mol Neurobiol","Exp Brain Res","Genetics","Drug Des Devel Ther","Cell","Alzheimers Res Ther","Ann Neurol","J Cell Sci","Int J Dev Neurosci","NPJ Genom Med","Alzheimers Dement (N Y)","BMC Res Notes","Neuropsychopharmacology","CNS Neurosci Ther","J Neuropathol Exp Neurol","Sci Rep","J Mol Neurosci","Cell Death Differ","Mol Neurobiol","Acta Neuropathol","Mol Cell Neurosci","EMBO J","Int J Mol Sci","Eur J Pharmacol","J Inflamm Res","Vaccines (Basel)","J Neurosci Res","Cell Rep","Biosci Biotechnol Biochem","Cell Death Dis","Molecules","Front Neurol","Clin Transl Med","Neurochem Int","Mol Med","Brain Behav","FEBS Lett","Nat Biomed Eng","Eur J Neurosci","Neurotoxicology","Mol Neurodegener","Mol Brain","Neuropharmacology","FASEB J","Sci Transl Med","Mol Biol Cell","Psychoneuroendocrinology","Front Neuroanat","J Biol Chem"],"speciesMap":{"Human":89,"Fruit fly":4,"C. elegans":1,"Mouse":139,"Rat":22,"Non-human primate":2,"Cat":1,"Hamster":1},"journalsMap":{"Life Sci":1,"NPJ Vaccines":2,"Brain":4,"Front Aging Neurosci":7,"Mol Med Rep":1,"Front Cell Neurosci":3,"Methods Mol Biol":1,"Nat Commun":7,"Biochem Biophys Res Commun":1,"Dis Model Mech":2,"Toxicology":1,"Nat Neurosci":1,"Nat Med":2,"Neurobiol Dis":5,"Alzheimers Dement":2,"Am J Pathol":5,"J Am Heart Assoc":1,"Food Chem Toxicol":1,"eNeuro":1,"ACS Chem Neurosci":2,"PLoS One":10,"Neurotherapeutics":1,"Adv Healthc Mater":1,"J Clin Med":1,"J Neurochem":4,"J Neuroinflammation":3,"Nat Struct Mol Biol":1,"J Alzheimers Dis":14,"Sci China Life Sci":1,"Bioact Mater":1,"Anesthesiology":1,"Redox Biol":1,"Neurosci Bull":1,"Elife":3,"PLoS Genet":1,"Neurodegener Dis":1,"Acta Biol Hung":1,"Brain Res":1,"Neurobiol Aging":14,"Hum Mol Genet":3,"J Neurosci":12,"Brain Pathol":2,"Biochim Biophys Acta":2,"Aging Cell":4,"iScience":3,"Nature":3,"Neural Plast":3,"Br J Pharmacol":1,"Front Behav Neurosci":1,"Am J Alzheimers Dis Other Demen":1,"Neural Regen Res":2,"Biol Psychiatry":1,"Neuron":2,"Acta Neuropathol Commun":4,"Proc Natl Acad Sci U S A":4,"Commun Biol":1,"Mol Psychiatry":4,"Sci Adv":3,"Front Cell Dev Biol":1,"J Nutr Biochem":1,"Front Mol Neurosci":3,"Antioxidants (Basel)":1,"Neuroscience":3,"Neurosci Lett":3,"Cell Mol Neurobiol":1,"Exp Brain Res":1,"Genetics":1,"Drug Des Devel Ther":1,"Cell":1,"Alzheimers Res Ther":2,"Ann Neurol":2,"J Cell Sci":1,"Int J Dev Neurosci":1,"NPJ Genom Med":1,"Alzheimers Dement (N Y)":1,"BMC Res Notes":1,"Neuropsychopharmacology":2,"CNS Neurosci Ther":1,"J Neuropathol Exp Neurol":2,"Sci Rep":9,"J Mol Neurosci":2,"Cell Death Differ":1,"Mol Neurobiol":4,"Acta Neuropathol":5,"Mol Cell Neurosci":1,"EMBO J":2,"Int J Mol Sci":5,"Eur J Pharmacol":1,"J Inflamm Res":1,"Vaccines (Basel)":1,"J Neurosci Res":1,"Cell Rep":4,"Biosci Biotechnol Biochem":1,"Cell Death Dis":4,"Molecules":1,"Front Neurol":1,"Clin Transl Med":1,"Neurochem Int":1,"Mol Med":1,"Brain Behav":1,"FEBS Lett":2,"Nat Biomed Eng":1,"Eur J Neurosci":1,"Neurotoxicology":1,"Mol Neurodegener":7,"Mol Brain":2,"Neuropharmacology":3,"FASEB J":2,"Sci Transl Med":1,"Mol Biol Cell":1,"Psychoneuroendocrinology":1,"Front Neuroanat":1,"J Biol Chem":11},"sortedMap":{}},{"applicationAbbreviation":"IHC","citations":[],"citationsCount":472,"speciesList":["Human","Fruit fly","Mouse","Rat","Non-human primate","Chimpanzee","Rabbit","Dog","Hamster","Pig"],"journals":["NPJ Vaccines","Brain","Mov Disord","Front Aging Neurosci","Arch Pathol Lab Med","Front Cell Neurosci","Methods Mol Biol","Nat Commun","Tremor Other Hyperkinet Mov (N Y)","Brain Res Bull","Invest Ophthalmol Vis Sci","Stem Cells","Nat Neurosci","J Med Chem","Neurobiol Dis","Alzheimers Dement","Exp Neurol","Am J Pathol","J Neural Transm (Vienna)","ACS Chem Neurosci","PLoS One","J Neurosci Methods","Brain Behav Immun","Aging (Albany NY)","J Neurol Neurosurg Psychiatry","J Clin Med","J Neurochem","Neuroimage","J Neuroinflammation","J Alzheimers Dis","Parkinsonism Relat Disord","Forensic Sci Int","J Cereb Blood Flow Metab","Bioact Mater","Neurosci Bull","Redox Biol","Hippocampus","Elife","PLoS Genet","BMC Neurol","Neurodegener Dis","Neuropathology","Brain Res","Neurobiol Aging","Neurol Genet","Hum Mol Genet","J Neurosci","Brain Pathol","Yonsei Med J","Behav Brain Res","Aging Cell","J Comp Pathol","iScience","Nature","Biomed Opt Express","Curr Alzheimer Res","Stroke","Prog Neurobiol","Front Behav Neurosci","J Alzheimers Dis Rep","J Clin Invest","Am J Alzheimers Dis Other Demen","JAMA Psychiatry","J Neurosurg","Biol Psychiatry","Cell Stem Cell","Mol Ther","Neuron","Healthcare (Basel)","Acta Neuropathol Commun","Proc Natl Acad Sci U S A","Neuroimage Clin","Mol Psychiatry","J Anat","Sci Adv","Exp Mol Med","Cell Tissue Res","Front Neurosci","Hum Pathol","Nat Protoc","Front Mol Neurosci","Neuroscience","Int J Alzheimers Dis","Fundam Clin Pharmacol","Int J Mol Med","Neurosci Lett","J Pathol","Geroscience","Br J Anaesth","Lab Invest","Ann Neurol","Alzheimers Res Ther","AIDS","Transl Neurodegener","J Neurovirol","Biometals","Neuropathol Appl Neurobiol","Alzheimers Dement (N Y)","Neurology","Neuropsychopharmacology","CNS Neurosci Ther","J Neuropathol Exp Neurol","Sci Rep","Mol Neurobiol","Acta Neuropathol","Biomedicines","Endocrinology","Transl Psychiatry","EMBO Mol Med","EMBO J","Int J Stroke","Int J Mol Sci","ChemMedChem","EJNMMI Res","J Exp Med","Vaccines (Basel)","J Neurosci Res","Methods Enzymol","Dement Geriatr Cogn Disord","Cell Rep","Cell Death Dis","Molecules","Folia Neuropathol","Front Neurol","J Neural Eng","Eur J Nucl Med Mol Imaging","J Comp Neurol","Brain Dev","Toxicol Pathol","Brain Lang","Brain Behav","Neurobiol Stress","FEBS Lett","Nat Biomed Eng","Eur J Neurosci","Mol Neurodegener","J Neurotrauma","Front Pharmacol","Neuropharmacology","Bioorg Med Chem","Theranostics","FASEB J","Cells","Sci Transl Med","Cell Res","Front Neuroanat","J Biol Chem","Brain Commun","Metab Brain Dis","Acta Biomater","Glia","Aging Dis","J Pathol Clin Res"],"speciesMap":{"Human":271,"Fruit fly":3,"Mouse":161,"Rat":20,"Non-human primate":6,"Chimpanzee":1,"Rabbit":1,"Dog":1,"Hamster":3,"Pig":1},"journalsMap":{"NPJ Vaccines":1,"Brain":13,"Mov Disord":11,"Front Aging Neurosci":11,"Arch Pathol Lab Med":1,"Front Cell Neurosci":1,"Methods Mol Biol":3,"Nat Commun":11,"Tremor Other Hyperkinet Mov (N Y)":1,"Brain Res Bull":1,"Invest Ophthalmol Vis Sci":1,"Stem Cells":1,"Nat Neurosci":1,"J Med Chem":1,"Neurobiol Dis":6,"Alzheimers Dement":2,"Exp Neurol":1,"Am J Pathol":4,"J Neural Transm (Vienna)":4,"ACS Chem Neurosci":1,"PLoS One":21,"J Neurosci Methods":2,"Brain Behav Immun":1,"Aging (Albany NY)":2,"J Neurol Neurosurg Psychiatry":2,"J Clin Med":1,"J Neurochem":2,"Neuroimage":1,"J Neuroinflammation":7,"J Alzheimers Dis":21,"Parkinsonism Relat Disord":5,"Forensic Sci Int":1,"J Cereb Blood Flow Metab":1,"Bioact Mater":2,"Neurosci Bull":1,"Redox Biol":1,"Hippocampus":1,"Elife":1,"PLoS Genet":1,"BMC Neurol":2,"Neurodegener Dis":1,"Neuropathology":6,"Brain Res":6,"Neurobiol Aging":13,"Neurol Genet":1,"Hum Mol Genet":3,"J Neurosci":19,"Brain Pathol":13,"Yonsei Med J":1,"Behav Brain Res":2,"Aging Cell":6,"J Comp Pathol":1,"iScience":2,"Nature":3,"Biomed Opt Express":1,"Curr Alzheimer Res":1,"Stroke":1,"Prog Neurobiol":1,"Front Behav Neurosci":1,"J Alzheimers Dis Rep":1,"J Clin Invest":2,"Am J Alzheimers Dis Other Demen":1,"JAMA Psychiatry":1,"J Neurosurg":1,"Biol Psychiatry":2,"Cell Stem Cell":1,"Mol Ther":2,"Neuron":2,"Healthcare (Basel)":1,"Acta Neuropathol Commun":33,"Proc Natl Acad Sci U S A":2,"Neuroimage Clin":2,"Mol Psychiatry":1,"J Anat":1,"Sci Adv":3,"Exp Mol Med":1,"Cell Tissue Res":1,"Front Neurosci":3,"Hum Pathol":1,"Nat Protoc":1,"Front Mol Neurosci":2,"Neuroscience":3,"Int J Alzheimers Dis":1,"Fundam Clin Pharmacol":1,"Int J Mol Med":1,"Neurosci Lett":1,"J Pathol":1,"Geroscience":1,"Br J Anaesth":1,"Lab Invest":1,"Ann Neurol":6,"Alzheimers Res Ther":2,"AIDS":1,"Transl Neurodegener":1,"J Neurovirol":1,"Biometals":1,"Neuropathol Appl Neurobiol":11,"Alzheimers Dement (N Y)":2,"Neurology":1,"Neuropsychopharmacology":1,"CNS Neurosci Ther":1,"J Neuropathol Exp Neurol":17,"Sci Rep":13,"Mol Neurobiol":1,"Acta Neuropathol":24,"Biomedicines":2,"Endocrinology":1,"Transl Psychiatry":1,"EMBO Mol Med":1,"EMBO J":1,"Int J Stroke":1,"Int J Mol Sci":5,"ChemMedChem":1,"EJNMMI Res":1,"J Exp Med":1,"Vaccines (Basel)":2,"J Neurosci Res":1,"Methods Enzymol":1,"Dement Geriatr Cogn Disord":1,"Cell Rep":3,"Cell Death Dis":3,"Molecules":2,"Folia Neuropathol":1,"Front Neurol":1,"J Neural Eng":1,"Eur J Nucl Med Mol Imaging":2,"J Comp Neurol":2,"Brain Dev":1,"Toxicol Pathol":1,"Brain Lang":1,"Brain Behav":1,"Neurobiol Stress":1,"FEBS Lett":1,"Nat Biomed Eng":1,"Eur J Neurosci":3,"Mol Neurodegener":5,"J Neurotrauma":2,"Front Pharmacol":1,"Neuropharmacology":4,"Bioorg Med Chem":1,"Theranostics":1,"FASEB J":1,"Cells":2,"Sci Transl Med":1,"Cell Res":1,"Front Neuroanat":3,"J Biol Chem":3,"Brain Commun":2,"Metab Brain Dis":1,"Acta Biomater":1,"Glia":3,"Aging Dis":1,"J Pathol Clin Res":1},"sortedMap":{}},{"applicationAbbreviation":"IHC (P)","citations":[],"citationsCount":42,"speciesList":["Human","Mouse","Cat","Dog","Pig"],"journals":["Brain","Neuropathology","Int J Mol Sci","Neurobiol Aging","Lancet Neurol","J Neurosci","Cell Mol Life Sci","Alzheimers Dement","Neurobiol Dis","J Comp Neurol","Aging Cell","Hum Mutat","Cell Rep Med","J Infect Dis","PLoS One","Mol Neurodegener","Neurobiol Learn Mem","Neuropathol Appl Neurobiol","J Neurochem","J Neuroinflammation","Acta Neuropathol Commun","J Alzheimers Dis","J Neuropathol Exp Neurol","Brain Commun","Sci Rep","Acta Neuropathol","Mol Cell Neurosci"],"speciesMap":{"Human":18,"Mouse":8,"Cat":1,"Dog":1,"Pig":1},"journalsMap":{"Brain":3,"Neuropathology":1,"Int J Mol Sci":1,"Neurobiol Aging":2,"Lancet Neurol":1,"J Neurosci":1,"Cell Mol Life Sci":1,"Alzheimers Dement":2,"Neurobiol Dis":1,"J Comp Neurol":2,"Aging Cell":1,"Hum Mutat":1,"Cell Rep Med":1,"J Infect Dis":1,"PLoS One":2,"Mol Neurodegener":2,"Neurobiol Learn Mem":1,"Neuropathol Appl Neurobiol":1,"J Neurochem":1,"J Neuroinflammation":2,"Acta Neuropathol Commun":4,"J Alzheimers Dis":1,"J Neuropathol Exp Neurol":3,"Brain Commun":1,"Sci Rep":1,"Acta Neuropathol":3,"Mol Cell Neurosci":1},"sortedMap":{}},{"applicationAbbreviation":"IHC (F)","citations":[],"citationsCount":9,"speciesList":["Human","Mouse"],"journals":["Cell Death Dis","Nat Aging","J Neuroinflammation","Nucl Med Biol","Acta Neuropathol Commun","J Alzheimers Dis","Sci Rep","Mol Neurobiol","Acta Neuropathol"],"speciesMap":{"Human":4,"Mouse":5},"journalsMap":{"Cell Death Dis":1,"Nat Aging":1,"J Neuroinflammation":1,"Nucl Med Biol":1,"Acta Neuropathol Commun":1,"J Alzheimers Dis":1,"Sci Rep":1,"Mol Neurobiol":1,"Acta Neuropathol":1},"sortedMap":{}},{"applicationAbbreviation":"IHC (Free)","citations":[],"citationsCount":16,"speciesList":["Human","Mouse","Rat"],"journals":["Brain","EMBO J","Front Cell Neurosci","Neurobiol Aging","J Exp Med","Autophagy","FASEB J","Biochim Biophys Acta","J Neurosci","Neuron","Sci Rep","Diabetes","Acta Neuropathol","Exp Neurol"],"speciesMap":{"Human":4,"Mouse":7,"Rat":2},"journalsMap":{"Brain":1,"EMBO J":1,"Front Cell Neurosci":1,"Neurobiol Aging":1,"J Exp Med":1,"Autophagy":1,"FASEB J":1,"Biochim Biophys Acta":1,"J Neurosci":2,"Neuron":1,"Sci Rep":1,"Diabetes":1,"Acta Neuropathol":2,"Exp Neurol":1},"sortedMap":{}},{"applicationAbbreviation":"ICC/IF","citations":[],"citationsCount":53,"speciesList":["Human","Mouse","Rat"],"journals":["Brain","EMBO Mol Med","Front Aging Neurosci","Mol Med Rep","Nat Protoc","Int J Mol Sci","Nat Commun","Front Cell Dev Biol","Neurobiol Aging","Int J Biol Macromol","J Neurosci Res","Autophagy","Hum Mol Genet","Cell Rep","Brain Pathol","J Neurosci","EBioMedicine","Antioxidants (Basel)","Nat Neurosci","Brain Struct Funct","Neurobiol Dis","J Mol Cell Biol","Aging Cell","iScience","PLoS One","J Hypertens","Age (Dordr)","Cell Stem Cell","Cell Res","J Neurochem","J Neuroinflammation","Cell Cycle","J Alzheimers Dis","J Biol Chem","Prion","Sci Rep","Acta Neuropathol","Redox Biol","Transl Psychiatry"],"speciesMap":{"Human":31,"Mouse":18,"Rat":1},"journalsMap":{"Brain":1,"EMBO Mol Med":1,"Front Aging Neurosci":1,"Mol Med Rep":1,"Nat Protoc":1,"Int J Mol Sci":1,"Nat Commun":2,"Front Cell Dev Biol":1,"Neurobiol Aging":1,"Int J Biol Macromol":1,"J Neurosci Res":1,"Autophagy":1,"Hum Mol Genet":1,"Cell Rep":1,"Brain Pathol":2,"J Neurosci":3,"EBioMedicine":1,"Antioxidants (Basel)":1,"Nat Neurosci":2,"Brain Struct Funct":1,"Neurobiol Dis":1,"J Mol Cell Biol":1,"Aging Cell":1,"iScience":1,"PLoS One":3,"J Hypertens":1,"Age (Dordr)":1,"Cell Stem Cell":1,"Cell Res":1,"J Neurochem":1,"J Neuroinflammation":1,"Cell Cycle":1,"J Alzheimers Dis":4,"J Biol Chem":1,"Prion":1,"Sci Rep":1,"Acta Neuropathol":5,"Redox Biol":1,"Transl Psychiatry":1},"sortedMap":{}},{"applicationAbbreviation":"Flow","citations":[],"citationsCount":4,"speciesList":["Human","Yeast"],"journals":["Biotechnol Prog","Neuron","Sci Rep","Am J Pathol"],"speciesMap":{"Human":3,"Yeast":1},"journalsMap":{"Biotechnol Prog":1,"Neuron":1,"Sci Rep":1,"Am J Pathol":1},"sortedMap":{}},{"applicationAbbreviation":"ELISA","citations":[],"citationsCount":8,"speciesList":["Human","Mouse"],"journals":["NPJ Vaccines","J Alzheimers Dis","Mol Neurodegener","Neurobiol Aging","Cell","Am J Pathol"],"speciesMap":{"Human":3,"Mouse":4},"journalsMap":{"NPJ Vaccines":1,"J Alzheimers Dis":2,"Mol Neurodegener":2,"Neurobiol Aging":1,"Cell":1,"Am J Pathol":1},"sortedMap":{}},{"applicationAbbreviation":"IP","citations":[],"citationsCount":2,"speciesList":["Human"],"journals":["Neurobiol Aging","J Biol Chem"],"speciesMap":{"Human":2},"journalsMap":{"Neurobiol Aging":1,"J Biol Chem":1},"sortedMap":{}},{"applicationAbbreviation":"PLA","citations":[],"citationsCount":1,"speciesList":["Human"],"journals":["Sci Rep"],"speciesMap":{"Human":1},"journalsMap":{"Sci Rep":1},"sortedMap":{}},{"applicationAbbreviation":"DB","citations":[],"citationsCount":1,"speciesList":["Human"],"journals":["Sci Adv"],"speciesMap":{"Human":1},"journalsMap":{"Sci Adv":1},"sortedMap":{}},{"applicationAbbreviation":"IA","citations":[],"citationsCount":1,"speciesList":["Mouse"],"journals":["ACS Chem Neurosci"],"speciesMap":{"Mouse":1},"journalsMap":{"ACS Chem Neurosci":1},"sortedMap":{}},{"applicationAbbreviation":"IDF","citations":[],"citationsCount":1,"speciesList":["Mouse"],"journals":["Neural Regen Res"],"speciesMap":{"Mouse":1},"journalsMap":{"Neural Regen Res":1},"sortedMap":{}},{"applicationAbbreviation":"Misc","citations":[],"citationsCount":21,"speciesList":["Human","Fruit fly","Mouse","Rat"],"journals":["Nature","Stem Cell Reports","Nat Protoc","Hum Mol Genet","Neuroscience","J Neuroimmunol","J Neurochem","Acta Neuropathol Commun","J Biol Chem","Neurobiol Dis","Alzheimers Dement","Sci Rep","Neuroreport","Acta Neuropathol"],"speciesMap":{"Human":10,"Fruit fly":1,"Mouse":7,"Rat":3},"journalsMap":{"Nature":1,"Stem Cell Reports":1,"Nat Protoc":1,"Hum Mol Genet":1,"Neuroscience":1,"J Neuroimmunol":1,"J Neurochem":3,"Acta Neuropathol Commun":3,"J Biol Chem":2,"Neurobiol Dis":2,"Alzheimers Dement":1,"Sci Rep":1,"Neuroreport":1,"Acta Neuropathol":2},"sortedMap":{}}]}; window.$mangular.tfRelatedProductsModuleURL = '/api/magellan/related-products-ui/widget/v2/'; THERMO_FISHER.pdp.productOrderComponent = {}; THERMO_FISHER.pdp.productOrderComponent.productDetailViewModel = {"sku":"MN1020","productSize":"100 µg","webId":"MN1020","packageDetails":[{"sku":"MN1020","size":"100 µg","onlinePriceApplicable":false,"entitled":true,"priced":false,"leadTimeEU":"1 business day","webId":"MN1020","searchStatus":true,"longTermUnavailable":false,"parentSku":true,"orderable":false,"discontinued":false,"thirdPartyProduct":false,"leadTimeCN":"1-2 weeks"}],"orderable":false,"longTermUnavailable":false,"discontinued":false}; THERMO_FISHER.pdp.productOrderComponent.productType = 'antibody'; THERMO_FISHER.pdp.productOrderComponent.productSubType = 'antibody_primary'; THERMO_FISHER.pdp.productOrderComponent.brand = 'Invitrogen'; THERMO_FISHER.pdp.productOrderComponent.userKey = "NONE"; THERMO_FISHER.pdp.productOrderComponent.productDesc = 'MN1020 recognizes a phosphatase-senstive epitope on PHF-Tau. No cross reactivity with normal Tau has been observed. The epitope of this antibody contains the phosphorylated Ser202 (4,5) residue (numbering according to human Tau40). <br /><br />MN1020 detects PHF-tau (Ser202/Thr205)a which has a predicted molecular weight of approximately 79 kDa.<br /><br />This product is a Low Endotoxin formulation. <br /><br />Purity is >95% as determined by SDS-PAGE.'; THERMO_FISHER.pdp.productOrderComponent.imageForSchemaMarkup = 'https://www.thermofisher.com/antibody/images/650/MN1020-PhosphoTau-ICC-20200824211338.jpg?time=20240507?time=20240507'; THERMO_FISHER.pdp.productOrderComponent.productSpecificationTableData = '[{"name":"Species Reactivity","value":"Human ,Mouse "},{"name":"Published species","value":"C. elegans ,Cat ,Chimpanzee ,Dog ,Fruit fly ,Hamster ,Human ,Mouse ,Non-human primate ,Pig ,Rabbit ,Rat ,Yeast "},{"name":"Host / Isotype","value":"Mouse/ IgG1, kappa"},{"name":"Class","value":"Monoclonal"},{"name":"Type","value":"Antibody"},{"name":"Clone","value":"AT8"},{"name":"Immunogen","value":"Partially purified human PHF-Tau"},{"name":"Conjugate","value":"Unconjugated "},{"name":"Form","value":"Liquid"},{"name":"Concentration","value":"0.2 mg/mL"},{"name":"Purification","value":"Protein A"},{"name":"Storage buffer","value":"PBS"},{"name":"Contains","value":"no preservative"},{"name":"Storage conditions","value":"-20° C, Avoid Freeze/Thaw Cycles"},{"name":"Shipping conditions","value":"Ambient (domestic); Wet ice (international)"},{"name":"RRID","value":"AB_223647"}]'; $m.userKey = "NONE"; angular.element(document).ready(function() { angular.bootstrap('#pdp-components', ['antibodyPdpModule']); }); THERMO_FISHER.pdp.sharedListComponent = THERMO_FISHER.pdp.sharedListComponent || {}; THERMO_FISHER.pdp.sharedListComponent.sharedList = null; </script> </div> <div class="documents"> <div class="documents-cntr" id="documents-container"> <div class="loading-wheel-lg hidden" id="documentLoadingWheel"></div> <div id="documentsUIRoot1"></div> </div>  <script defer type="text/javascript" src="/store/v2/documents/static/conditionalLoadAssets.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script>  <script> window.THERMO_FISHER = window.THERMO_FISHER || {}; THERMO_FISHER.pdp = THERMO_FISHER.pdp || {}; THERMO_FISHER.pdp.documents = THERMO_FISHER.pdp.documents || {}; THERMO_FISHER.pdp.documents.selectedProductId = 'MN1020'; THERMO_FISHER.pdp.documents.documentsFetched = false; THERMO_FISHER.pdp.documents.reqParam = { containerId: 'documentsUIRoot1', skus: [THERMO_FISHER.pdp.documents.selectedProductId], showCertificates: true, showSds: true, showOthers: true, expanded: 'true' }; THERMO_FISHER.pdp.documents.docSectionEle = document.getElementById("rootPdpDocLoader"); var documentLoadingWheel = document.getElementById("documentLoadingWheel"); THERMO_FISHER.pdp.documents.fetchDocuments = function() { setTimeout(function() { var docUi = document.getElementsByClassName("product-documents-ui"); if (typeof documentsConfiguration != "undefined" && typeof docUi != "undefined") { documentsConfiguration([THERMO_FISHER.pdp.documents.reqParam]); THERMO_FISHER.pdp.documents.documentsFetched = true; documentLoadingWheel.classList.add("hidden"); } else { console.log("loadDocuments: window.documentsConfiguration is UNDEFINED"); } }, 3000); }; if(THERMO_FISHER.pdp.documents.docSectionEle){ THERMO_FISHER.pdp.documents.intersectionObserver = new IntersectionObserver(function(elements) { elements.forEach(function(entry) { if(!THERMO_FISHER.pdp.documents.documentsFetched && entry.intersectionRatio >= 0.07){ documentLoadingWheel.classList.remove("hidden"); THERMO_FISHER.pdp.documents.fetchDocuments(); } }); }); THERMO_FISHER.pdp.documents.intersectionObserver.observe(THERMO_FISHER.pdp.documents.docSectionEle); } </script> </div> <div class="two-up-module-container">   <div class="two-up-row" id="bottom-cta-banner" style="display: block;"> <div class="two-up-row-divider container"> <div class="row"> <div class="span5 medium-span-5 small-span-12"> <img src="https://www.thermofisher.com/content/dam/LifeTech/global/life-sciences/Antibodies/images/guarantee.png" class="column-image" alt="guarantee_icon" loading="lazy"> <h2 class="two-up-header">Performance Guarantee</h2> <p class="two-up-paragraph">If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*</p> <a href="https://www.thermofisher.com/us/en/home/life-science/antibodies/antibody-performance-guarantee.html" class="btn two-up-btn performance-guarantee-button">Learn more</a> </div> <div class="span5 medium-span-5 small-span-12 right-content"> <img src="https://www.thermofisher.com/content/dam/LifeTech/global/life-sciences/Antibodies/images/help.png" class="column-image" alt="help_icon" loading="lazy"> <h2 class="two-up-header">We're here to help</h2> <p class="two-up-paragraph">Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.</p> <a id="tech_link" href="https://www.thermofisher.com/us/en/home/technical-resources/contact-us.MN1020.html?supportType=TS" class="btn two-up-btn" >Contact tech support</a> </div> </div> </div> </div> </div> </div> </div> <script> // load global functions callIfOrWhenWindowLoaded(window.THERMO_FISHER.scroll.init()); </script> <link rel="stylesheet" type="text/css" href="/order/genome-database/assets/core/dist/fonts/thermofisher.icons.css?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"/> </div>  </div> </div> <div class="footer group"> <style> .no-logo{ min-height: 80px; } </style> <footer id="tf-global-footer" style=""> <div class="globalFooter" data-orig="tfpt-header-footer" data-app-env="prod" data-site="tf" data-hostname="www.thermofisher.com" data-x-host="www.thermofisher.com" data-env="prod" data-hash="468bd07150dbbf" data-version="4.03.29" data-analytics-section="header" data-aem-syndication-info="(sg:en-sg:anonymous:https-tf)" data-aem-syndication-timestamp="globalHeader: Wed, 27 Nov 2024 12:56:54 GMT" data-optional-selectors="inlineCss,globalRoute">           <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("globalFooter:renderBegin"); </script>  <style data-inline-file-name='footer.min.css' data-inline-site='tf'>/* Hash: 468bd07150dbbf Source: /tf/css/dist/footer.min.css */ @charset "UTF-8";@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.woff2) format("woff2");font-weight:lighter;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.woff2) format("woff2");font-weight:100;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.woff2) format("woff2");font-weight:200;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.woff2) format("woff2");font-weight:300;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.woff2) format("woff2");font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.woff2) format("woff2");font-weight:400;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-56Italic.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-56Italic.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-56Italic.woff2) format("woff2");font-weight:400;font-style:italic;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.woff2) format("woff2");font-weight:500;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.woff2) format("woff2");font-weight:600;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.woff2) format("woff2");font-weight:700;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.woff2) format("woff2");font-weight:800;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.woff2) format("woff2");font-weight:900;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.woff2) format("woff2");font-weight:700;font-style:normal;font-display:swap}footer,header{font-family:HelveticaNeue,sans-serif;-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%;max-width:100%;scroll-behavior:smooth;color:#1b1b1d;margin:0}footer *,header *{-webkit-box-sizing:border-box;-moz-box-sizing:border-box;box-sizing:border-box}footer :after,footer :before,header :after,header :before{-webkit-box-sizing:border-box;-moz-box-sizing:border-box;box-sizing:border-box}footer :focus-visible,header :focus-visible{outline:2px solid #802eff}footer input:focus-visible,header input:focus-visible{outline:0}footer .bold-label,header .bold-label{font-weight:700}footer .h1,footer .h2,footer .h3,footer .h4,footer .h5,footer .h6,footer body,footer h1,footer h2,footer h3,footer h4,footer h5,footer h6,header .h1,header .h2,header .h3,header .h4,header .h5,header .h6,header body,header h1,header h2,header h3,header h4,header h5,header h6{color:#222}footer .text-light,footer .text-light .display-1,footer .text-light .display-2,footer .text-light .display-3,footer .text-light .display-4,footer .text-light .h1,footer .text-light .h2,footer .text-light .h3,footer .text-light .h4,footer .text-light .h5,footer .text-light .h6,footer .text-light body,footer .text-light h1,footer .text-light h2,footer .text-light h3,footer .text-light h4,footer .text-light h5,footer .text-light h6,header .text-light,header .text-light .display-1,header .text-light .display-2,header .text-light .display-3,header .text-light .display-4,header .text-light .h1,header .text-light .h2,header .text-light .h3,header .text-light .h4,header .text-light .h5,header .text-light .h6,header .text-light body,header .text-light h1,header .text-light h2,header .text-light h3,header .text-light h4,header .text-light h5,header .text-light h6{color:#fff}footer body,header body{margin:0;font-size:16px;line-height:26px}footer p,header p{margin-top:0;margin-bottom:0;font-size:16px;line-height:26px}footer .p-grey,header .p-grey{color:#54545c}footer .text-center,header .text-center{text-align:center}footer .alt,header .alt{font-size:16px;line-height:26px}footer .text-size-14,header .text-size-14{font-size:14px;line-height:22px}footer a,header a{text-decoration:none;color:#1b1b1d}footer a:hover,header a:hover{text-decoration:none;color:#1b1b1d}footer a:visited,header a:visited{text-decoration:none;color:#1b1b1d}footer .disabled,header .disabled{color:#a2a2a2}footer .label-medium,header .label-medium{color:#222;font-size:16px;line-height:26px;font-weight:400}footer .label-bold,header .label-bold{color:#222;font-size:16px;line-height:26px;font-weight:bolder}footer .hint,header .hint{font-size:14px;line-height:30.727268px}footer .blockquote,header .blockquote{color:#222;font-size:20.571424px;line-height:33.090902px;margin-bottom:0}footer .alt-color,header .alt-color{color:#54545c}footer .success,header .success{color:#3bad2f}footer .warning,header .warning{color:#ed7700}footer .error,header .error{color:#e71316}footer .thin,header .thin{font-weight:lighter}footer .light,header .light{font-weight:300}footer .italic,header .italic{font-style:italic}footer .medium,header .medium{font-weight:700}footer .bold,header .bold{font-weight:bolder}footer .h1,footer .h2,footer .h3,footer .h5,footer h1,footer h2,footer h3,footer h5,header .h1,header .h2,header .h3,header .h5,header h1,header h2,header h3,header h5{font-weight:400;margin:0;padding-bottom:10px}footer .h4,footer h4,header .h4,header h4{font-weight:600;margin:0;padding-bottom:10px}footer .h6,footer h6,header .h6,header h6{font-weight:400;margin:0;padding-bottom:10px}footer .display-1,footer .display-2,footer .display-3,footer .display-4,header .display-1,header .display-2,header .display-3,header .display-4{font-family:HelveticaNeueLight,Helvetica,Roboto,"Segoe UI",Arial,sans-serif;font-weight:lighter}footer .h1,footer h1,header .h1,header h1{font-size:32px;line-height:40px}footer .h2,footer h2,header .h2,header h2{font-size:26px;line-height:33px}footer .h3,footer h3,header .h3,header h3{font-size:22px;line-height:28px}footer .h4,footer h4,header .h4,header h4{font-size:20px;line-height:25px}footer .h5,footer h5,header .h5,header h5{font-size:18px;line-height:23px}footer .h6,footer h6,header .h6,header h6{font-size:16px;line-height:20px}footer .display-1,header .display-1{font-size:40px;line-height:50px}footer .display-2,header .display-2{font-size:32px;line-height:40px}footer .display-3,header .display-3{font-size:24px;line-height:30px}footer .display-4,header .display-4{font-weight:300;font-size:30px;line-height:38px}@media (max-width:768px){footer .h1,footer h1,header .h1,header h1{font-size:26px;line-height:33px}footer .h2,footer h2,header .h2,header h2{font-size:21px;line-height:26px}footer .h3,footer h3,header .h3,header h3{font-size:18px;line-height:23px}footer .h4,footer h4,header .h4,header h4{font-size:16px;line-height:20px}footer .h5,footer h5,header .h5,header h5{font-size:16px;line-height:20px}footer .h6,footer h6,header .h6,header h6{font-size:16px;line-height:20px}footer .display-1,header .display-1{font-size:40px;line-height:50px}footer .display-2,header .display-2{font-size:32px;line-height:40px}footer .display-3,header .display-3{font-size:24px;line-height:30px}footer .display-4,header .display-4{font-weight:300;font-size:30px;line-height:38px}}footer .font-size-14,header .font-size-14{font-size:14px}footer .font-size-16,header .font-size-16{font-size:16px}footer .font-size-18,header .font-size-18{font-size:18px}footer .font-size-20,header .font-size-20{font-size:20px}footer .font-size-22,header .font-size-22{font-size:22px}footer .font-size-24,header .font-size-24{font-size:24px}footer .font-size-26,header .font-size-26{font-size:26px}footer fieldset,header fieldset{display:block;margin-inline-start:0;margin-inline-end:0;padding-block-start:0;padding-inline-start:0;padding-inline-end:0;padding-block-end:0;border-width:0;border-style:none}@media print{footer .cmp-p-pageheadinghero,header .cmp-p-pageheadinghero{display:none}footer .cmp-p-manualnav,header .cmp-p-manualnav{display:none}footer .header-cmp,header .header-cmp{display:none}footer .cmp-p-anchorlist,header .cmp-p-anchorlist{display:none}footer .cmp-p-ctaitem,header .cmp-p-ctaitem{display:none}footer .footer,header .footer{display:none}footer .cmp-p-testimonial,header .cmp-p-testimonial{display:none}footer td,footer th,header td,header th{padding-top:4px;padding-bottom:4px;height:30px}}.m-l1{margin:16px}.m-l2{margin:24px}.m-l3{margin:32px}.m-l4{margin:48px}.m-l5{margin:64px}.m-l0{margin:0!important}.mx-l1{margin:0 16px}.mx-l2{margin:0 24px}.mx-l3{margin:0 32px}.mx-l4{margin:0 48px}.mx-l5{margin:0 64px}.mx-l1{margin:16px 0}.mx-l2{margin:24px 0}.mx-l3{margin:32px 0}.mx-l4{margin:48px 0}.mx-l5{margin:64px 0}.mt-l1{margin-top:16px}.mt-l2{margin-top:24px}.mt-l3{margin-top:32px}.mt-l4{margin-top:48px}.mt-l5{margin-top:64px}.mb-l1{margin-bottom:16px}.mb-l2{margin-bottom:24px}.mb-l3{margin-bottom:32px}.mb-l4{margin-bottom:48px}.mb-l5{margin-bottom:64px}.ml-l1{margin-left:16px}.ml-l2{margin-left:24px}.ml-l3{margin-left:32px}.ml-l4{margin-left:48px}.ml-l5{margin-left:64px}.mr-l1{margin-right:16px}.mr-l2{margin-right:24px}.mr-l3{margin-right:32px}.mr-l4{margin-right:48px}.mr-l5{margin-right:64px}.p-l1{padding:16px}.p-l2{padding:24px}.p-l3{padding:32px}.p-l4{padding:48px}.p-l5{padding:64px}.p-l0{padding:0!important}.px-l1{padding:0 16px}.px-l2{padding:0 24px}.px-l3{padding:0 32px}.px-l4{padding:0 48px}.px-l5{padding:0 64px}.px-l1{padding:16px 0}.px-l2{padding:24px 0}.px-l3{padding:32px 0}.px-l4{padding:48px 0}.px-l5{padding:64px 0}.pt-l1{padding-top:16px}.pt-l2{padding-top:24px}.pt-l3{padding-top:32px}.pt-l4{padding-top:48px}.pt-l5{padding-top:64px}.pb-l1{padding-bottom:16px}.pb-l2{padding-bottom:24px}.pb-l3{padding-bottom:32px}.pb-l4{padding-bottom:48px}.pb-l5{padding-bottom:64px}.pl-l1{padding-left:16px}.pl-l2{padding-left:24px}.pl-l3{padding-left:32px}.pl-l4{padding-left:48px}.pl-l5{padding-left:64px}.pr-l1{padding-right:16px}.pr-l2{padding-right:24px}.pr-l3{padding-right:32px}.pr-l4{padding-right:48px}.pr-l5{padding-right:64px}.mt-s0{margin-top:0}.mt-s1{margin-top:2px}.mt-s2{margin-top:4px}.mt-s3{margin-top:8px}.mt-s4{margin-top:12px}.mt-s5{margin-top:16px}.mt-s6{margin-top:24px}.mt-s7{margin-top:32px}.mt-s8{margin-top:40px}.mt-s9{margin-top:48px}.mb-s0{margin-bottom:0}.mb-s1{margin-bottom:2px}.mb-s2{margin-bottom:4px}.mb-s3{margin-bottom:8px}.mb-s4{margin-bottom:12px}.mb-s5{margin-bottom:16px}.mb-s6{margin-bottom:24px}.mb-s7{margin-bottom:32px}.mb-s8{margin-bottom:40px}.mb-s9{margin-bottom:48px}.ml-s0{margin-left:0}.ml-s1{margin-left:2px}.ml-s2{margin-left:4px}.ml-s3{margin-left:8px}.ml-s4{margin-left:12px}.ml-s5{margin-left:16px}.ml-s6{margin-left:24px}.ml-s7{margin-left:32px}.ml-s8{margin-left:40px}.ml-s9{margin-left:48px}.mr-s0{margin-right:0}.mr-s1{margin-right:2px}.mr-s2{margin-right:4px}.mr-s3{margin-right:8px}.mr-s4{margin-right:12px}.mr-s5{margin-right:16px}.mr-s6{margin-right:24px}.mr-s7{margin-right:32px}.mr-s8{margin-right:40px}.mr-s9{margin-right:48px}.pt-s0{padding-top:0}.pt-s1{padding-top:2px}.pt-s2{padding-top:4px}.pt-s3{padding-top:8px}.pt-s4{padding-top:12px}.pt-s5{padding-top:16px}.pt-s6{padding-top:24px}.pt-s7{padding-top:32px}.pt-s8{padding-top:40px}.pt-s9{padding-top:48px}.pb-s0{padding-bottom:0}.pb-s1{padding-bottom:2px}.pb-s2{padding-bottom:4px}.pb-s3{padding-bottom:8px}.pb-s4{padding-bottom:12px}.pb-s5{padding-bottom:16px}.pb-s6{padding-bottom:24px}.pb-s7{padding-bottom:32px}.pb-s8{padding-bottom:40px}.pb-s9{padding-bottom:48px}.pl-s0{padding-left:0}.pl-s1{padding-left:2px}.pl-s2{padding-left:4px}.pl-s3{padding-left:8px}.pl-s4{padding-left:12px}.pl-s5{padding-left:16px}.pl-s6{padding-left:24px}.pl-s7{padding-left:32px}.pl-s8{padding-left:40px}.pl-s9{padding-left:48px}.pr-s0{padding-right:0}.pr-s1{padding-right:2px}.pr-s2{padding-right:4px}.pr-s3{padding-right:8px}.pr-s4{padding-right:12px}.pr-s5{padding-right:16px}.pr-s6{padding-right:24px}.pr-s7{padding-right:32px}.pr-s8{padding-right:40px}.pr-s9{padding-right:48px}footer{padding-top:40px;background-color:#fff}footer .footer .footer-menu{width:100%;background-color:#f7f7f7;padding:0}footer .footer .footer-menu-container{max-width:1440px;margin:auto;padding:0;font-size:14px;display:flex;justify-content:space-between;flex-direction:column}footer .footer .footer-menu-col{padding-bottom:8px}footer .footer .footer-menu-col ul{list-style-type:none;margin-left:0;padding-inline-start:0;max-height:0;transition:height .3s ease-in;overflow:hidden;margin-bottom:-12px}footer .footer .footer-menu-col ul li{font-weight:400;line-height:24px}footer .footer .footer-menu-col ul li .external-link-icon{height:16px;width:16px;margin-left:10px;margin-bottom:-2px;display:inline-block;background-image:url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16'%3E%3Cpath class='external-link-icon' d='M15 1V8.24H13V4.4l-6 6L5.56 9l6-6H7.75V1ZM11.28 13.09H2.89V4.7H5.61V2.8H1V15H13.17v-4.7H11.28Z'/%3E%3C/svg%3E")}footer .footer .footer-menu-col.open .footer-menu-label .icon .plus-icon-svg{display:none}footer .footer .footer-menu-col.open .footer-menu-label .icon .minus-icon-svg{display:inline-block}footer .footer .footer-menu-col.open ul{max-height:500px;transition:height .3s ease-out;margin:0 16px 16px}footer .footer .footer-menu-label{font-weight:700;line-height:22px;padding:16px;border-top:1px solid #e5e5e5}footer .footer .footer-menu-label .icon{float:right;margin-right:16px;width:24px;display:inline-block;pointer-events:none}footer .footer .footer-menu-label .icon .minus-icon-svg{display:none}footer .footer .footer-menu-label a,footer .footer .footer-menu-label a:visited{color:#222}footer .footer .footer-legal{width:100%}footer .footer .footer-legal-container{max-width:1440px;margin:auto;padding:0 16px;display:flex;justify-content:space-between;flex-direction:column;font-size:14px}footer .footer .footer-legal-container-select{display:inline-block;text-align:left;justify-content:flex-start;align-items:center;font-weight:500;font-size:14px;line-height:22px;width:100%;margin-bottom:16px}footer .footer .footer-legal-container-select .ml-l1{margin-left:0;margin-right:0}footer .footer .footer-legal-container-select select{margin-bottom:0;background-color:transparent}footer .footer .footer-legal-container-select label{display:block;padding-bottom:6px;padding-right:12px}footer .footer .footer-legal-container-select .cmp-ctaitem{margin-top:0}footer .footer .footer-legal-container-select .cmp-ctaitem button{display:inline-block;text-align:center;margin:0;border-radius:3px;font-weight:700;font-size:14px;padding:0 24px 0 24px;box-sizing:border-box;line-height:32px;text-decoration:none;cursor:pointer;transition:background 250ms ease-in-out,transform 150ms ease;-webkit-appearance:none;-moz-appearance:none;width:auto;color:#555759;background-color:#fff;border:solid 1px #dcdcdc}footer .footer .footer-legal-container-select .cmp-ctaitem__anchor{margin-left:16px}footer .footer .footer-legal-container-select .cmp-p-dropdown{display:inherit;float:left;margin-right:16px}footer .footer .footer-legal-container-select .cmp-p-dropdown .cmp-dropdown{position:relative}footer .footer .footer-legal-container-select .cmp-p-dropdown .cmp-dropdown__toggle{border:1px solid #ccc;border-left:4px solid #0079d8;min-width:220px;text-align:left;font-weight:700;line-height:30px;height:34px}footer .footer .footer-legal-container-select .cmp-p-dropdown .cmp-dropdown__toggleicon{height:0;width:0;margin:12px;border-left:4px solid transparent;border-right:4px solid transparent;border-top:6px solid #222}footer .footer .footer-legal-container-select .cmp-p-dropdown .cmp-dropdown__toggleicon:after{display:none}footer .footer .footer-legal-container-select .cmp-p-dropdown .cmp-dropdown select{appearance:none}footer .footer .footer-legal-container-select .cmp-p-dropdown .cmp-dropdown::after{content:"‣";position:absolute;top:6px;right:12px;font-size:34px;transform:rotate(90deg);z-index:-1}footer .footer .footer-legal-container #form-select-language{margin-top:0}footer .footer .footer-legal-container .cn-footer{color:#54545c;font-size:12px;margin-bottom:120px}footer .footer .footer-legal-link{font-size:12px;font-weight:400;line-height:15px}footer .footer .footer-legal-link ul{list-style-type:none;margin-left:0;padding-inline-start:0;margin-bottom:0}footer .footer .footer-legal-link ul li{padding-bottom:12px}footer .footer .footer-legal-link ul li a{margin-bottom:12px}footer .footer .footer-legal .all-rights{display:block;color:#54545c;margin-bottom:12px;max-width:600px}footer .footer .footer-legal-logo{width:99px;margin-top:24px}footer .footer .footer-legal .privacy-policy-bold{font-weight:700}footer .footer .footer-legal-country{display:flex;margin-bottom:0;justify-content:flex-start}footer .footer .footer-legal-country .country-flag{height:16px;width:16px;display:inline-block;margin-right:16px}footer .footer a,footer .footer a:link,footer .footer a:visited{color:#54545c}@media (min-width:576px){footer .footer .footer-legal-container-select .cmp-p-dropdown{margin-bottom:0}footer .footer .footer-legal-link{font-size:14px;font-weight:400;line-height:22px}footer .footer .footer-legal-link ul li{padding-bottom:0;display:inline-block;padding-right:16px;padding-left:16px;border-right:1px solid #dcdcdc}footer .footer .footer-legal-link ul li:first-child{padding-left:0}footer .footer .footer-legal-link ul li:last-child{border-right:none}footer .footer .footer-legal-list .privacy-policy-bold{font-weight:700}}@media (min-width:768px){footer .footer .footer-legal-link{font-size:11px;line-height:13px;display:flex;align-items:center}footer .footer .footer-legal-logo{width:120px;margin:16px 0}footer .footer .footer-legal-logo .tf-logo-cls-1{fill:#e71316}footer .footer .footer-legal-logo .tf-logo-cls-2{fill:#fff}footer .footer .footer-legal-list{width:100%;margin-left:24px}footer .footer .footer-legal-list ul{margin-top:0;margin-bottom:0}footer .footer .footer-legal-list li{margin-bottom:10px}footer .footer .footer-legal-list .privacy-policy-bold{font-weight:700}footer .footer .footer-legal .all-rights{display:block;color:#54545c;margin-bottom:12px;max-width:600px}footer .footer .footer-legal-country{margin-bottom:14px;min-width:140px}footer .footer .footer-legal .footer-legal-country{display:flex;margin-top:16px;justify-content:flex-end}footer .footer .footer-legal .footer-legal-country .country-flag{height:24px;margin-right:5px}}@media (min-width:992px){footer .footer .footer-menu{padding:0 24px}footer .footer .footer-menu-container{flex-direction:row;padding:0 16px}footer .footer .footer-menu-col{margin-top:0;margin-block-start:14px}footer .footer .footer-menu-col.open ul{margin:0}footer .footer .footer-menu-col ul{display:block;max-height:500px;padding-bottom:42px;margin-block-start:9px}footer .footer .footer-menu-col ul li{min-height:30px}footer .footer .footer-menu-label{border-top:none;padding:16px 0 0}footer .footer .footer-menu-label .icon{display:none}footer .footer .footer-legal-container{padding-bottom:42px;margin-top:24px}footer .footer .footer-legal-container .cn-footer{margin-bottom:0}footer .footer .footer-legal .privacy-policy-bold{font-weight:700}}@media (min-width:1200px){footer .footer .footer-legal-container-select{display:flex;text-align:left;align-self:flex-end;justify-content:flex-end;align-items:center;font-weight:500;font-size:14px;line-height:22px;width:100%;margin-bottom:16px}footer .footer .footer-legal-container #form-select-language{margin-top:-32px}footer .footer .footer-legal .privacy-policy-bold{font-weight:700}}.cmp-dropdown{position:relative}.cmp-dropdown *{box-sizing:border-box}.cmp-dropdown .cmp-dropdown__toggle{position:relative;display:inline-block;padding:0 30px 0 10px;line-height:40px;border:1px solid #222;text-decoration:none;color:#222}.cmp-dropdown .cmp-dropdown__toggleicon{position:absolute;height:40px;width:20px;transform:translate(0,0);top:0;right:0}.cmp-dropdown .cmp-dropdown__toggleicon:after{font-family:icomoon;font-size:8px;content:"\ee2c";display:inline-block}.cmp-dropdown .cmp-dropdown__menu{display:none;position:absolute;z-index:1;transform:translate(0,0);will-change:transform;padding:5px;background-color:#eee;border:1px solid #222}.cmp-dropdown.open .cmp-dropdown__toggleicon:after{transform:rotate(180deg)}.cmp-dropdown.open .cmp-dropdown__menu{display:block}.footer-menu-container ul li a img{width:14px;height:14px;top:2px;position:relative} /*# sourceMappingURL=footer.min.css.map */ </style> <script type="text/javascript" src="/store/global-header-footer-static/tf/js/utilities.min.468bd07150dbbf.js" async></script>  <div class="footer "> <div class="footer-menu"> <div class="footer-menu-container"> <div id="footer-menu-category-1" class="footer-menu-col pragma-toggle-component"> <div class="footer-menu-label pragma-toggle" data-analytics-section="footer" data-analytics-container="Ordering" data-toggle="#footer-menu-category-1" data-toggle-classes="open"> Ordering <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="plus-icon-svg" data-toggle="#footer-menu-category-1" data-toggle-classes="open"> <title>Plus Icon</title> <g> <path d="M22,13H13v9H11V13H2V11h9V2h2v9h9Z" /> </g> </svg> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="minus-icon-svg" data-toggle="#footer-menu-category-1" data-toggle-classes="open"> <title>Minus Icon</title> <g> <path d="M22,11v2H2V11Z" /> </g> </svg> </span> </div> <ul> <li> <a href="/store/orders/solu" onclick="" id="footer-link-1-1" data-analytics-section="footer" data-analytics-container="Ordering" data-analytics-text="Order Status">Order Status <span></span> </a> </li> <li> <a href="/sg/en/home/support/how-to-place-orders.html" onclick="" id="footer-link-1-4" data-analytics-section="footer" data-analytics-container="Ordering" data-analytics-text="Order Help">Order Help <span></span> </a> </li> <li> <a href="/store/v2/quick-order" onclick="" id="footer-link-1-5" data-analytics-section="footer" data-analytics-container="Ordering" data-analytics-text="Quick Order">Quick Order <span></span> </a> </li> <li> <a href="/sg/en/home/products-and-services/supply-center.html" onclick="" id="footer-link-1-6" data-analytics-section="footer" data-analytics-container="Ordering" data-analytics-text="Supply Center">Supply Center <span></span> </a> </li> <li> <a href="/sg/en/home/digital-solutions/ecommerce/b2b.html" onclick="" id="footer-link-1-7" data-analytics-section="footer" data-analytics-container="Ordering" data-analytics-text="eProcurement">eProcurement <span></span> </a> </li> </ul> </div> <div id="footer-menu-category-2" class="footer-menu-col pragma-toggle-component"> <div class="footer-menu-label pragma-toggle" data-analytics-section="footer" data-analytics-container="Support" data-toggle="#footer-menu-category-2" data-toggle-classes="open"> Support <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="plus-icon-svg" data-toggle="#footer-menu-category-2" data-toggle-classes="open"> <title>Plus Icon</title> <g> <path d="M22,13H13v9H11V13H2V11h9V2h2v9h9Z" /> </g> </svg> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="minus-icon-svg" data-toggle="#footer-menu-category-2" data-toggle-classes="open"> <title>Minus Icon</title> <g> <path d="M22,11v2H2V11Z" /> </g> </svg> </span> </div> <ul> <li> <a href="/sg/en/home/support.html" onclick="" id="footer-link-2-1" data-analytics-section="footer" data-analytics-container="Support" data-analytics-text="Help and Support">Help and Support <span></span> </a> </li> <li> <a href="/sg/en/home/technical-resources/contact-us.html" onclick="" id="footer-link-2-2" data-analytics-section="footer" data-analytics-container="Support" data-analytics-text="Contact Us">Contact Us <span></span> </a> </li> <li> <a href="/sg/en/home/technical-resources/technical-reference-library.html" onclick="" id="footer-link-2-3" data-analytics-section="footer" data-analytics-container="Support" data-analytics-text="Technical Support Centers">Technical Support Centers <span></span> </a> </li> <li> <a href="/sg/en/home/support/documents-certificates.html" onclick="" id="footer-link-2-4" data-analytics-section="footer" data-analytics-container="Support" data-analytics-text="Documents and Certificates">Documents and Certificates <span></span> </a> </li> <li> <a href="javascript:KAMPYLE_ONSITE_SDK.showForm(29308);void(0);" onclick="" id="footer-link-2-5" data-analytics-section="footer" data-analytics-container="Support" data-analytics-text="Report a Site Issue">Report a Site Issue <span></span> </a> </li> </ul> </div> <div id="footer-menu-category-3" class="footer-menu-col pragma-toggle-component"> <div class="footer-menu-label pragma-toggle" data-analytics-section="footer" data-analytics-container="Resources" data-toggle="#footer-menu-category-3" data-toggle-classes="open"> Resources <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="plus-icon-svg" data-toggle="#footer-menu-category-3" data-toggle-classes="open"> <title>Plus Icon</title> <g> <path d="M22,13H13v9H11V13H2V11h9V2h2v9h9Z" /> </g> </svg> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="minus-icon-svg" data-toggle="#footer-menu-category-3" data-toggle-classes="open"> <title>Minus Icon</title> <g> <path d="M22,11v2H2V11Z" /> </g> </svg> </span> </div> <ul> <li> <a href="/sg/en/home/technical-resources/learning-centers.html" onclick="" id="footer-link-3-1" data-analytics-section="footer" data-analytics-container="Resources" data-analytics-text="Learning Centers">Learning Centers <span></span> </a> </li> <li> <a href="/sg/en/home/products-and-services/promotions.html" onclick="" id="footer-link-3-2" data-analytics-section="footer" data-analytics-container="Resources" data-analytics-text="Promotions">Promotions <span></span> </a> </li> <li> <a href="/sg/en/home/about-us/events.html" onclick="" id="footer-link-3-3" data-analytics-section="footer" data-analytics-container="Resources" data-analytics-text="Events and Webinars">Events and Webinars <span></span> </a> </li> <li> <a href="/sg/en/home/communities-social/socialhub.html" onclick="" id="footer-link-3-4" data-analytics-section="footer" data-analytics-container="Resources" data-analytics-text="Social Media">Social Media <span></span> </a> </li> </ul> </div> <div id="footer-menu-category-4" class="footer-menu-col pragma-toggle-component"> <div class="footer-menu-label pragma-toggle" data-analytics-section="footer" data-analytics-container="About Thermo Fisher" data-toggle="#footer-menu-category-4" data-toggle-classes="open"> About Thermo Fisher <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="plus-icon-svg" data-toggle="#footer-menu-category-4" data-toggle-classes="open"> <title>Plus Icon</title> <g> <path d="M22,13H13v9H11V13H2V11h9V2h2v9h9Z" /> </g> </svg> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="minus-icon-svg" data-toggle="#footer-menu-category-4" data-toggle-classes="open"> <title>Minus Icon</title> <g> <path d="M22,11v2H2V11Z" /> </g> </svg> </span> </div> <ul> <li> <a href="https://corporate.thermofisher.com/en/home.html" onclick="" id="footer-link-4-1" data-analytics-section="footer" data-analytics-container="About Thermo Fisher" data-analytics-text="About Us">About Us <img src="/store/global-header-footer-static/global/svg/external-link-bold.svg" alt="About Us"> <span></span> </a> </li> <li> <a href="https://jobs.thermofisher.com/global/en" onclick="" id="footer-link-4-2" data-analytics-section="footer" data-analytics-container="About Thermo Fisher" data-analytics-text="Careers">Careers <img src="/store/global-header-footer-static/global/svg/external-link-bold.svg" alt="Careers"> <span></span> </a> </li> <li> <a href="http://ir.thermofisher.com/investors/Investor-Overview/default.aspx" onclick="" id="footer-link-4-3" data-analytics-section="footer" data-analytics-container="About Thermo Fisher" data-analytics-text="Investors">Investors <img src="/store/global-header-footer-static/global/svg/external-link-bold.svg" alt="Investors"> <span></span> </a> </li> <li> <a href="https://thermofisher.mediaroom.com" onclick="" id="footer-link-4-4" data-analytics-section="footer" data-analytics-container="About Thermo Fisher" data-analytics-text="News">News <img src="/store/global-header-footer-static/global/svg/external-link-bold.svg" alt="News"> <span></span> </a> </li> <li> <a href="http://corporate.thermofisher.com/en/responsibility.html" onclick="" id="footer-link-4-5" data-analytics-section="footer" data-analytics-container="About Thermo Fisher" data-analytics-text="Social Responsibility">Social Responsibility <img src="/store/global-header-footer-static/global/svg/external-link-bold.svg" alt="Social Responsibility"> <span></span> </a> </li> <li> <a href="/sg/en/home/global/trademark-information.html" onclick="" id="footer-link-4-6" data-analytics-section="footer" data-analytics-container="About Thermo Fisher" data-analytics-text="Trademarks">Trademarks <span></span> </a> </li> </ul> </div> <div id="footer-menu-category-5" class="footer-menu-col pragma-toggle-component"> <div class="footer-menu-label pragma-toggle" data-analytics-section="footer" data-analytics-container="Our Portfolio" data-toggle="#footer-menu-category-5" data-toggle-classes="open"> Our Portfolio <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="plus-icon-svg" data-toggle="#footer-menu-category-5" data-toggle-classes="open"> <title>Plus Icon</title> <g> <path d="M22,13H13v9H11V13H2V11h9V2h2v9h9Z" /> </g> </svg> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="minus-icon-svg" data-toggle="#footer-menu-category-5" data-toggle-classes="open"> <title>Minus Icon</title> <g> <path d="M22,11v2H2V11Z" /> </g> </svg> </span> </div> <ul> <li> <a href="/sg/en/home/brands/thermo-scientific.html" onclick="" id="footer-link-5-1" data-analytics-section="footer" data-analytics-container="Our Portfolio" data-analytics-text="Thermo Scientific">Thermo Scientific <span></span> </a> </li> <li> <a href="/sg/en/home/brands/applied-biosystems.html" onclick="" id="footer-link-5-2" data-analytics-section="footer" data-analytics-container="Our Portfolio" data-analytics-text="Applied Biosystems">Applied Biosystems <span></span> </a> </li> <li> <a href="/sg/en/home/brands/invitrogen.html" onclick="" id="footer-link-5-3" data-analytics-section="footer" data-analytics-container="Our Portfolio" data-analytics-text="Invitrogen">Invitrogen <span></span> </a> </li> <li> <a href="/sg/en/home/brands/gibco.html" onclick="" id="footer-link-5-4" data-analytics-section="footer" data-analytics-container="Our Portfolio" data-analytics-text="Gibco">Gibco <span></span> </a> </li> <li> <a href="/sg/en/home/brands/ion-torrent.html" onclick="" id="footer-link-5-5" data-analytics-section="footer" data-analytics-container="Our Portfolio" data-analytics-text="Ion Torrent">Ion Torrent <span></span> </a> </li> <li> <a href="/sg/en/home/brands/fisher-scientific.html" onclick="" id="footer-link-5-6" data-analytics-section="footer" data-analytics-container="Our Portfolio" data-analytics-text="Fisher Scientific">Fisher Scientific <span></span> </a> </li> <li> <a href="/sg/en/home/brands/patheon.html" onclick="" id="footer-link-5-7" data-analytics-section="footer" data-analytics-container="Our Portfolio" data-analytics-text="Patheon">Patheon <span></span> </a> </li> <li> <a href="/sg/en/home/brands/ppd.html" onclick="" id="footer-link-5-8" data-analytics-section="footer" data-analytics-container="Our Portfolio" data-analytics-text="PPD">PPD <span></span> </a> </li> </ul> </div> </div> </div> <div class="footer-legal"> <div class="footer-legal-container"> <div class="footer-legal-link "> <div class="footer-legal-logo"> <svg id="Layer_1" data-name="Layer 1" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 485.52 223.55"> <defs> <style> .tf-logo-cls-1 { fill: #ee3134; } .tf-logo-cls-2 { fill: #fff; } </style> </defs> <rect class="tf-logo-cls-1" width="485.52" height="223.55"/> <path class="tf-logo-cls-2" d="M108.27,83.11V76h-32v7.13h11v31h9.92v-31Zm123.5,31c-.26-2.53-.42-4.49-.42-5.81V95.46c0-5.33-3.91-8.65-9.08-8.65a10.21,10.21,0,0,0-8.82,4.69c-1.11-3-4.38-4.54-7.44-4.54-3.7,0-6.81,1.22-8.55,4.54l-.22-4h-9.07V114.1h9.39v-16c0-.84-.37-5.38,4-5.38,2.91,0,3.59,2.59,3.59,5.12V114.1h9.34v-16c0-.84-.37-5.38,4-5.38,2.91,0,3.6,2.59,3.6,5.12V114.1ZM186,95.35V87.28c-4.07,0-7.18,1.27-8.39,5.33l-.22-5.07H168c.21,2.17.21,5.07.21,6.82V114.1h9.4V102.48c0-4.38,1.26-7.07,6.44-7.17.63,0,1.26,0,1.95,0m62-8.54c-8.66,0-14.31,4.8-14.31,13.93,0,9.4,5.71,14.1,14.31,14.1s14.31-4.7,14.31-14.1c0-9.13-5.65-13.93-14.31-13.93m0,5.59c4,0,4.7,4.06,4.7,8.23,0,4.86-.85,8.66-4.7,8.66s-4.7-3.8-4.7-8.66c0-4.22.74-8.28,4.7-8.28ZM137.21,114.1a57.55,57.55,0,0,1-.37-5.81V95.46c0-5.33-4-8.65-9.13-8.65a11.12,11.12,0,0,0-4.44.84,9.58,9.58,0,0,0-3.38,2.69V76H110.5V114.1h9.39v-16c0-.84-.36-5.38,4-5.38,3,0,3.59,2.59,3.59,5.12V114.1Zm28.72-11.46c0-9.55-2.8-15.83-13.41-15.83-8.39,0-13.41,5.17-13.41,13.25,0,9.92,3.54,14.78,13.88,14.78a14.49,14.49,0,0,0,8.24-2.22,9.58,9.58,0,0,0,4.49-7.29h-8.87a4.15,4.15,0,0,1-4.49,4.07c-3.59,0-4.32-3.43-4.27-6.76Zm-9-5.12h-8.71c.21-2.8.84-5.65,4.32-5.8a3.49,3.49,0,0,1,3.33,1.84,7.36,7.36,0,0,1,1.06,4Z"/> <path class="tf-logo-cls-2" d="M409.29,94.88V86.81c-4.06-.06-7.18,1.26-8.39,5.33l-.21-4.6H391.3c.2,2.17.2,5.07.2,6.81v19.74h9.4V102.48c0-4.38,1.27-7.54,6.44-7.65.63,0,1.26,0,2,0m-48.87,19.21a54.56,54.56,0,0,1-.37-5.8V95.47c0-5.34-4-8.66-9.13-8.66a10.52,10.52,0,0,0-4.33.84,9.73,9.73,0,0,0-3.49,2.69V76h-9.39v38.11h9.39v-16c0-.84-.37-5.38,4-5.38,2.95,0,3.59,2.58,3.59,5.12v16.25Zm-29-7.91c0-4.12-2.16-6.12-5.17-7.23-5.65-2-9.88-2.11-9.88-4.23a2.24,2.24,0,0,1,2.44-2.48,3.34,3.34,0,0,1,2.52.85,3.7,3.7,0,0,1,.69,2.53h8.92c-.21-7-5.7-8.81-11.72-8.81-5.12,0-11.76,1.79-11.76,8.18,0,9.29,15,6.86,15,11.82,0,1.75-1.43,2.53-3.28,2.53a2.92,2.92,0,0,1-2.42-1.26,3.36,3.36,0,0,1-.58-2.59h-9c-.16,7.92,5.7,9.35,12.19,9.35,6.08,0,12-2.22,12-8.66m57.78-3.54c.06-9.55-2.79-15.83-13.41-15.83-8.39,0-13.41,5.17-13.41,13.25,0,9.92,3.54,14.78,13.89,14.78a14.56,14.56,0,0,0,8.23-2.22,9.52,9.52,0,0,0,4.49-7.29H380.1a4.14,4.14,0,0,1-4.48,4.07c-3.59,0-4.33-3.43-4.28-6.76Zm-9-5.12H371.5c.21-2.8.84-5.65,4.33-5.8a3.51,3.51,0,0,1,3.33,1.85,7.38,7.38,0,0,1,1,4Zm-75.39-10h-9.39V114.1h9.39ZM292.5,83l2.22-7H269.47v38.11h9.92v-15h8l2.21-7H279.39V83Zm12.32,0,2.23-7h-9.29l-2.22,7Z"/> <path class="tf-logo-cls-2" d="M162.45,125.26h3.44v21.61h-3.44Zm232,22c-7.21,0-12.59-4-12.59-11s6-11.42,12.81-11.42a13.4,13.4,0,0,1,6.78,1.9l-1.77,2.09a10.44,10.44,0,0,0-5-1.41,9,9,0,0,0-6.85,2.64,8.89,8.89,0,0,0-2.18,6.33,7.9,7.9,0,0,0,2.56,6.3c1.65,1.63,4.18,2.08,6.66,2.08a12.1,12.1,0,0,0,5.46-1.55l1.68,2a14.64,14.64,0,0,1-7.59,2m-36.24-22h3.44v21.61h-3.44Zm-77.92,2.58h-8.05v19h-3.36v-19h-8v-2.58h19.77ZM100.78,146.1a13.66,13.66,0,0,1-6.09,1.22A20.13,20.13,0,0,1,86,145.37l1.43-2.45a16.3,16.3,0,0,0,7.54,1.82,7.65,7.65,0,0,0,3.93-.88,3.14,3.14,0,0,0,1.9-2.79c0-1.81-1.39-2.93-4.73-3.71l-3.51-.82c-3.5-.82-5.7-3-5.7-5.56,0-3.68,3.62-6.29,8.78-6.29a16.39,16.39,0,0,1,8.29,2.06L102.33,129a13.46,13.46,0,0,0-6.55-1.73c-3.07,0-5.2,1.19-5.2,3.22,0,1.56,1.3,2.49,4.31,3.22l3.25.78a11.33,11.33,0,0,1,4.78,2.18,5.38,5.38,0,0,1,1.68,3.86,6.4,6.4,0,0,1-3.82,5.57m138.41.77-8.58-11.52c-1.61-2.16-4.33-6.38-4.33-6.38s.3,3.65.32,6.85l.09,11.05h-3.43V125.26h4.09L236,137c1.69,2.29,4,5.92,4,5.92s-.52-4-.54-6.84l-.08-10.85h3.4v21.61Zm59.2-21.61h3.45v21.61h-3.45Zm41,2.54H327.56v6.4h10v2.54h-10v10.13h-3.45V125.26h15.76ZM188.17,146.87V125.26H204.1l-.46,2.58h-12v6.44h10.24v2.58h-10.2v7.3h12.86v2.71Zm-52.36.37c-7.2,0-12.58-4-12.58-11s6-11.42,12.8-11.42a13.4,13.4,0,0,1,6.78,1.9l-1.76,2.09a10.44,10.44,0,0,0-5-1.41,9,9,0,0,0-6.86,2.64,8.89,8.89,0,0,0-2.18,6.33,7.9,7.9,0,0,0,2.57,6.3c1.65,1.63,4.17,2.08,6.65,2.08a12.1,12.1,0,0,0,5.46-1.55l1.68,2a14.59,14.59,0,0,1-7.59,2"/> </svg> </div> <div class="footer-legal-list"> <ul class="footer-legal-list"> <li class=""> <a href="/sg/en/home/global/terms-and-conditions.html" id="hfTermsOfServiceLink" data-analytics-section="footer" data-analytics-container="legal" data-analytics-text="Terms & Conditions">Terms & Conditions</a> </li> <li class=""> <a href="/sg/en/home/global/privacy-policy.html" id="hfPrivacyPolicyLink" data-analytics-section="footer" data-analytics-container="legal" data-analytics-text="Privacy Policy">Privacy Policy</a> </li> <li class=""> <a href="/sg/en/home/global/online-pricing-policy.html" id="hfOnlinePricePolicyLink" data-analytics-section="footer" data-analytics-container="legal" data-analytics-text="Price & Freight Policy">Price & Freight Policy</a> </li> <li> <div id="teconsent"></div> <div id="consent_blackbar"></div> </li> </ul> <div class="all-rights">© 2006-2024 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.</div> </div> <style> .test-svg { font-size: 14px; } </style> <div class="footer-legal-country"> <div class="country-flag"> <img class="country-flag-img" src="/store/global-header-footer-static/global/images/flags/sg.gif" alt="Singapore flag icon" data-uw-rm-ima-original="Singapore flag icon"> </div> <div class="country-name">Singapore</div> </div> </div>  <script type="text/javascript"> if(document.getElementById('language-select')){ var myOpts = document.getElementById('language-select').options; for(var i = 0; i < myOpts.length; i++){ if((window.location.pathname.split("/")[2] == myOpts[i].value) || (getCookie('CK_LANG_CODE') == myOpts[i].value)){ myOpts[i].setAttribute("selected", "selected"); } } } </script> </div> </div> <script> // DTM footer init if ( window._satellite && window._satellite.pageBottom ) { window._satellite.pageBottom(); } </script> <script> /* START: Global header promo config */ // var globalHeaderPromoConfig = { // "Promos": [ // { // "Text":"Ordering online is fast & simple.", // "LinkText":"Register today", // "ISO": "us ca", //use this if you need to restrict to an iso // "LANG": "en", //use this if you need to restrict to a certain language // "URL": "/auth/create-account&ICID=L0-HP-TB-EBIZ-RS001-registeronline-20160921-SG", // "URLAppendISO": false //If using an ICID, you can use this to have the current ISO automatically appended // } // ], // "Config": { // 'HideDisplayTypes':'B2B SCMS' // } // }; /* END: Global header promo config */ /* START: Global Header Promo Display Logic */ // function initGlobalHeaderPromo(){ // if ( typeof(globalHeaderPromoConfig) === 'object' ) { // $('.global-promo').remove(); //Do not display promo for B2B. You can change these display types in the config file. // var hideDisplayTypes = globalHeaderPromoConfig.Config.HideDisplayTypes.split(" "); // for( var i=0; i< hideDisplayTypes.length;i++){ // if ( _lt.displayTypeMatch( hideDisplayTypes[i]) ) return false; // } //Ok Usertype? Let's go for it, then... Let's loop through our promos and see if they can be displayed for this user // for ( var promoKey in globalHeaderPromoConfig.Promos ) { // var thisPromo = globalHeaderPromoConfig.Promos[promoKey]; // if ( thisPromo.ISO && !_lt.displayIsoMatch( thisPromo.ISO ) ) continue; // if ( thisPromo.LANG && !_lt.displayLangMatch( thisPromo.LANG ) ) continue; //Append the current user's ISO code to the end of the URL ( for tracking ) // if ( thisPromo.URLAppendISO && thisPromo.URLAppendISO !== false ) { // thisPromo.URL = thisPromo.URL+'-'+_lt.user.displayIso; // } // if ( window.messagingBar ) window.messagingBar.addPromo(thisPromo.Text,thisPromo.LinkText,thisPromo.URL); //Promo displayed - let's return true // return true; // } //Promo Loop // } //Config Check //Promo did not display.. Return false. // return false; // } // $(document).ready(initGlobalHeaderPromo) ; /* END: Global Header Promo Display Logic */ </script>  <style> /* turn bar red - THIS IS ONLY for emergencies */ /* #messagingBar.messaging-bar-promos { background: #ee3134; }*/ /* #messagingBarClose{display:none !important } */ </style>  <style> @media(min-width: 980px) { .template-2-column .mondrian-module-f { height: auto !important; } .mondrian-featured-list { display: table; height: 100%; margin: 0; padding: 0; position: relative; width: 100%; } .mondrian-module-list ul li, .mondrian-module-list ul.default li, .mondrian-module-list ul.mondrian-featured-list li { display: table-row !important; border-bottom: 1px solid #fff !important; border-bottom-width: 1px !important; border-bottom-style: solid !important; border-bottom-color: rgb(255, 255, 255) !important; word-break: normal !important; } } @media(min-width:767px) { .mondrian-module-list ul li, .mondrian-module-list ul.default li, .mondrian-module-list ul.mondrian-featured-list li { display: table-row!important; border-bottom: 1px solid #fff !important; word-break: normal !important; } } </style> </div>    <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("globalFooter:renderEnd"); </script> <script id="localizedCountriesInfoURL" type="text/javascript"> var ltCountryInfo = {"af":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/af.gif","name":"Afghanistan","phone":"\t<a href='/af/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"al":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/al.gif","name":"Albania","phone":"<a href='/al/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"dz":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/dz.gif","name":"Algeria","phone":"<a href='/dz/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ad":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ad.gif","name":"Andorra","phone":"<a href='/ad/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ao":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ao.gif","name":"Angola","phone":"<a href='/ao/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"aq":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/emptyflag.gif","name":"Antarctica","phone":"<a href='/aq/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":true,"registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"ag":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ag.gif","name":"Antigua and Barbuda","phone":"<a href='/ag/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ar":{"defaultLanguage":"es","flag":"/shared-static/images/icons/flags/ar.gif","name":"Argentina","phone":"<a href='/ar/en/home/technical-resources/contact-us.html'>Contacto</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_AR"},"aw":{"defaultLanguage":"en","name":"Aruba","phone":"<a href='/aw/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"am":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/am.gif","name":"Armenia","phone":"<a href='/am/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"au":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/au.gif","name":"Australia","phone":"<a href='/au/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_AA"},"at":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/at.gif","name":"Austria","phone":"<a href='/at/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"az":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/az.gif","name":"Azerbaijan","phone":"<a href='/az/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"bs":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bs.gif","name":"Bahamas","phone":"<a href='/bs/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"bh":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bh.gif","name":"Bahrain","phone":"<a href='/bh/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"bd":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bd.gif","name":"Bangladesh","phone":"<a href='/bd/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SA"},"bb":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bb.gif","name":"Barbados","phone":"<a href='/bb/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"by":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/by.gif","name":"Belarus","phone":"<a href='/by/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"be":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/be.gif","name":"Belgium","phone":"<a href='/be/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"bz":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bz.gif","name":"Belize","phone":"<a href='/bz/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"bj":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bj.gif","name":"Benin","phone":"<a href='/bj/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"bm":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bm.gif","name":"Bermuda","phone":"<a href='/bm/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"bt":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bt.gif","name":"Bhutan","phone":"<a href='/in/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"IPAC_SA"},"bo":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bo.gif","name":"Bolivia","phone":"<a href='/bo/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"ba":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ba.gif","name":"Bosnia and Herzegovina","phone":"<a href='/ba/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"bw":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bw.gif","name":"Botswana","phone":"<a href='/bw/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"bv":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bv.gif","name":"Bouvet Island","phone":"<a href='/bv/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"br":{"defaultLanguage":"pt","flag":"/shared-static/images/icons/flags/br.gif","name":"Brasil","phone":"<a href='/br/en/home/technical-resources/contact-us.html'>Contato</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_BR"},"bn":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bn.gif","name":"Brunei Darussalam","phone":"<a href='/bn/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SEA"},"bg":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bg.gif","name":"Bulgaria","phone":"<a href='/bg/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"bf":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bf.gif","name":"Burkina Faso","phone":"<a href='/bf/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"bi":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bi.gif","name":"Burundi","phone":"<a href='/bi/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"kh":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/kh.gif","name":"Cambodia","phone":"<a href='/kh/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SEA"},"cm":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cm.gif","name":"Cameroon","phone":"<a href='/cm/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ca":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ca.gif","name":"Canada","phone":"<a href='/ca/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","quickLinkIndex":"1","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.ca","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"NA"},"ic":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ic.gif","name":"Canary Islands","phone":"<a href='/ic/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"cv":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cv.gif","name":"Cape Verde","phone":"<a href='/cv/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ky":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ky.gif","name":"Cayman Islands","phone":"<a href='/ky/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"cf":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cf.gif","name":"Central African Republic","phone":"<a href='/cf/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"td":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/td.gif","name":"Chad","phone":"<a href='/td/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"cl":{"defaultLanguage":"es","flag":"/shared-static/images/icons/flags/cl.gif","name":"Chile","phone":"<a href='/cl/en/home/technical-resources/contact-us.html'>Contacto</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_CL"},"cn":{"defaultLanguage":"zh","flag":"/shared-static/images/icons/flags/cn.gif","name":"China | 中国","phone":"<a href='/cn/en/home/technical-resources/contact-us.html'>联系我们</a>","signInHidden":"","registerHidden":"","euCountry":"","quickLinkIndex":"2","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brandGroup":"1","groupDisplay":"","regionMapping":"GC_CN"},"co":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/co.gif","name":"Colombia","phone":"<a href='/co/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"km":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/km.gif","name":"Comoros","phone":"<a href='/km/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"cg":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cg.gif","name":"Congo","phone":"<a href='/cg/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":" Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"cd":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cd.gif","name":"Congo (Democratic Republic of)","phone":"<a href='/cd/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"cr":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cr.gif","name":"Costa Rica","phone":"<a href='/cr/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"ci":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ci.gif","name":"Cote Dlvoire (Ivory Coast)","phone":"<a href='/ci/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"hr":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/hr.gif","name":"Croatia (Hrvatska)","phone":"<a href='/hr/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"cw":{"defaultLanguage":"en","name":"Curaçao","phone":"<a href='/cw/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":true,"registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"cy":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cy.gif","name":"Cyprus","phone":"<a href='/cy/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"cz":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cz.gif","name":"Czech Republic","phone":"<a href='/cz/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"dk":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/dk.gif","name":"Denmark","phone":"<a href='/dk/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"dj":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/dj.gif","name":"Djibouti","phone":"<a href='/dj/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"dm":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/dm.gif","name":"Dominica","phone":"<a href='/dm/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"do":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/do.gif","name":"Dominican Republic","phone":"<a href='/do/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"ec":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ec.gif","name":"Ecuador","phone":"<a href='/ec/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"eg":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/eg.gif","name":"Egypt","phone":"<a href='/eg/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services ","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"sv":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sv.gif","name":"El Salvador","phone":"<a href='/sv/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"er":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/er.gif","name":"Eritrea","phone":"<a href='/er/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ee":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ee.gif","name":"Estonia","phone":"<a href='/ee/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"et":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/et.gif","name":"Ethiopia","phone":"<a href='/et/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"fo":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/fo.gif","name":"Faroe Islands","phone":"<a href='/fo/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"fj":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/fj.gif","name":"Fiji","phone":"<a href='/fj/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_AA"},"fi":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/fi.gif","name":"Finland","phone":"<a href='/fi/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"fr":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/fr.gif","name":"France Metropolitan","phone":"<a href='/fx/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"gf":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gf.gif","name":"French Guyana","phone":"<a href='/gf/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"pf":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/pf.gif","name":"French Polynesia","phone":"<a href='/pf/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"IPAC_AA"},"ga":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ga.gif","name":"Gabon","phone":"<a href='/ga/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"gm":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gm.gif","name":"Gambia","phone":"<a href='/gm/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ge":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ge.gif","name":"Georgia","phone":"<a href='/ge/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"de":{"defaultLanguage":"de","flag":"/shared-static/images/icons/flags/de.gif","name":"Germany | Deutschland","phone":"<a href='/de/en/home/technical-resources/contact-us.html'>Kontaktieren Sie uns</a>","signInHidden":"","registerHidden":"","euCountry":true,"quickLinkIndex":"3","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"gh":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gh.gif","name":"Ghana","phone":"<a href='/gh/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"gi":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gi.gif","name":"Gibraltar","phone":"<a href='/gi/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"gr":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gr.gif","name":"Greece","phone":"<a href='/gr/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"gl":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gl.gif","name":"Greenland","phone":"<a href='/gl/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":true,"registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"gd":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gd.gif","name":"Grenada","phone":"<a href='/gd/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"gp":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gp.gif","name":"Guadeloupe","phone":"<a href='/gp/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"gu":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gu.gif","name":"Guam","phone":"<a href='/gu/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"IPAC_SEA"},"gt":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gt.gif","name":"Guatemala","phone":"<a href='/gt/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"gn":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gn.gif","name":"Guinea","phone":"<a href='/gn/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"gy":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gy.gif","name":"Guyana","phone":"<a href='/gy/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"ht":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ht.gif","name":"Haiti","phone":"<a href='/ht/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"hn":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/hn.gif","name":"Honduras","phone":"<a href='/hn/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"hk":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cn.gif","name":"Hong Kong","phone":"<a href='/tw/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"GC"},"hu":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/hu.gif","name":"Hungary","phone":"<a href='/hu/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"is":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/is.gif","name":"Iceland","phone":"<a href='/is/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"in":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/in.gif","name":"India","phone":"<a href='/in/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","quickLinkIndex":"4","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.in","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SA"},"id":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/id.gif","name":"Indonesia","phone":"<a href='/id/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SEA"},"iq":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/iq.gif","name":"Iraq","phone":"<a href='/iq/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ie":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ie.gif","name":"Ireland","phone":"<a href='/ie/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"il":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/il.gif","name":"Israel","phone":"<a href='/il/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"it":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/it.gif","name":"Italy","phone":"<a href='/it/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"jm":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/jm.gif","name":"Jamaica","phone":"<a href='/jm/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"jp":{"defaultLanguage":"ja","flag":"/shared-static/images/icons/flags/jp.gif","name":"Japan | 日本","phone":"<a href='/jp/en/home/technical-resources/contact-us.html'>お問い合わせ</a>","signInHidden":"","registerHidden":"","euCountry":"","quickLinkIndex":"5","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"/jp/ja/home/brands/fisher-scientific.html","brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"JP"},"jo":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/jo.gif","name":"Jordan","phone":"<a href='/jo/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"kz":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/kz.gif","name":"Kazakhstan","phone":"<a href='/kz/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ke":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ke.gif","name":"Kenya","phone":"<a href='/ke/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"kr":{"defaultLanguage":"ko","flag":"/shared-static/images/icons/flags/kr.gif","name":"Korea | 대한민국","phone":"<a href='/kr/en/home/technical-resources/contact-us.html'>연락처</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"/content/lifetech/global/en/home/brands/fisher-scientific","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"IPAC_KR"},"kw":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/kw.gif","name":"Kuwait","phone":"<a href='/kw/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"kg":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/kg.gif","name":"Kyrgyzstan","phone":"<a href='/kg/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"la":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/la.gif","name":"Laos","phone":"<a href='/la/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"IPAC_SEA"},"lv":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/lv.gif","name":"Latvia","phone":"<a href='/lv/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"lb":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/lb.gif","name":"Lebanon","phone":"<a href='/lb/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ls":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ls.gif","name":"Lesotho","phone":"<a href='/ls/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"defaultcountry":{"defaultLanguage":"en","name":"Default Country","phone":"","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"groupDisplay":""},"lr":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/lr.gif","name":"Liberia","phone":"<a href='/lr/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ly":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ly.gif","name":"Libya","phone":"<a href='/ly/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"li":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/li.gif","name":"Liechtenstein","phone":"<a href='/li/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":" Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"lt":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/lt.gif","name":"Lithuania","phone":"<a href='/lt/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"lu":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/lu.gif","name":"Luxembourg","phone":"<a href='/lu/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"mo":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cn.gif","name":"Macau","phone":"<a href='/mo/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mk":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mk.gif","name":"Macedonia","phone":"<a href='/mk/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mg":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mg.gif","name":"Madagascar","phone":"<a href='/mg/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mw":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mw.gif","name":"Malawi","phone":"<a href='/mw/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"my":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/my.gif","name":"Malaysia","phone":"<a href='/my/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com.my","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SEA"},"mv":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mv.gif","name":"Maldives","phone":"<a href='/mv/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SA"},"ml":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ml.gif","name":"Mali","phone":"<a href='/ml/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mt":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mt.gif","name":"Malta","phone":"<a href='/mt/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mq":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mq.gif","name":"Martinique","phone":"<a href='/mq/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"mr":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mr.gif","name":"Mauritania","phone":"<a href='/mr/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mu":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mu.gif","name":"Mauritius","phone":"<a href='/mu/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"yt":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/yt.gif","name":"Mayotte","phone":"<a href='/yt/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mx":{"defaultLanguage":"es","flag":"/shared-static/images/icons/flags/mx.gif","name":"México","phone":"<a href='/mx/en/home/technical-resources/contact-us.html'>Contacto</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_MX"},"md":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/md.gif","name":"Moldova","phone":"<a href='/md/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mc":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mc.gif","name":"Monaco","phone":"<a href='/mc/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"mn":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mn.gif","name":"Mongolia","phone":"<a href='/mn/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"me":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/me.gif","name":"Montenegro","phone":"<a href='/me/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ms":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ms.gif","name":"Montserrat","phone":"<a href='/ms/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":true,"registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"ma":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ma.gif","name":"Morocco","phone":"<a href='/ma/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mz":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mz.gif","name":"Mozambique","phone":"<a href='/mz/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mm":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mm.gif","name":"Myanmar","phone":"<a href='/mm/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SEA"},"na":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/na.gif","name":"Namibia","phone":"<a href='/na/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"np":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/np.gif","name":"Nepal","phone":"<a href='/np/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SA"},"nl":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/nl.gif","name":"Netherlands","phone":"<a href='/nl/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"nc":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/nc.gif","name":"New Caledonia","phone":"<a href='/nc/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":""},"nz":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/nz.gif","name":"New Zealand (Aotearoa)","phone":"<a href='/nz/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_AA"},"ni":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ni.gif","name":"Nicaragua","phone":"<a href='/ni/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"ne":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ne.gif","name":"Niger","phone":"<a href='/ne/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ng":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ng.gif","name":"Nigeria","phone":"<a href='/ng/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"no":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/no.gif","name":"Norway","phone":"<a href='/no/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"om":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/om.gif","name":"Oman","phone":"<a href='/om/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"pk":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/pk.gif","name":"Pakistan","phone":"<a href='/pk/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":""},"ps":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ps.gif","name":"Palestine","phone":"<a href='/ps/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"pa":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/pa.gif","name":"Panamá","phone":"<a href='/pa/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"pg":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/pg.gif","name":"Papua New Guinea","phone":"<a href='/pg/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_AA"},"py":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/py.gif","name":"Paraguay","phone":"<a href='/py/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"pe":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/pe.gif","name":"Perú","phone":"<a href='/pe/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"ph":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ph.gif","name":"Philippines","phone":"<a href='/ph/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":true,"registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SEA"},"pl":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/pl.gif","name":"Poland","phone":"<a href='/pl/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"pt":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/pt.gif","name":"Portugal","phone":"<a href='/pt/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"pr":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/pr.gif","name":"Puerto Rico","phone":"<a href='/pr/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"qa":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/qa.gif","name":"Qatar","phone":"<a href='/qa/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"re":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/re.gif","name":"Reunion","phone":"<a href='/re/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ro":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ro.gif","name":"Romania","phone":"<a href='/ro/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ru":{"defaultLanguage":"ru","flag":"/shared-static/images/icons/flags/ru.gif","name":"Russia | Россия","phone":"<a href='/ru/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"rw":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/rw.gif","name":"Rwanda","phone":"<a href='/rw/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"gs":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gs.gif","name":"S. Georgia and S. Sandwich Isls.","phone":"<a href='/gs/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"kn":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/kn.gif","name":"Saint Kitts and Nevis","phone":"<a href='/kn/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"lc":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/lc.gif","name":"Saint Lucia","phone":"<a href='/lc/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"vc":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/vc.gif","name":"Saint Vincent and the Grenadines","phone":"<a href='/vc/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"sm":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sm.gif","name":"San Marino","phone":"<a href='/sm/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"st":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/st.gif","name":"Sao Tome and Principe","phone":"<a href='/st/en/home/technical-resources/contact-us.html?supportType=OS#ordersupport'>Order Support</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"sa":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sa.gif","name":"Saudi Arabia","phone":"<a href='/sa/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"sn":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sn.gif","name":"Senegal","phone":"<a href='/sn/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"rs":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/rs.gif","name":"Serbia","phone":"<a href='/rs/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"sc":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sc.gif","name":"Seychelles","phone":"<a href='/sc/en/home/technical-resources/contact-us.html?supportType=OS#ordersupport'>Order Support</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"sl":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sl.gif","name":"Sierra Leone","phone":"<a href='/sl/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"sg":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sg.gif","name":"Singapore","phone":"<a href='/sg/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"http://myfisherstore.com/singapore/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SP"},"sk":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sk.gif","name":"Slovak Republic","phone":"<a href='/sk/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":" Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"si":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/si.gif","name":"Slovenia","phone":"<a href='/si/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"so":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/so.gif","name":"Somalia","phone":"<a href='/so/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"za":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/za.gif","name":"South Africa","phone":"<a href='/za/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"es":{"defaultLanguage":"es","flag":"/shared-static/images/icons/flags/es.gif","name":"Spain","phone":"<a href='/es/en/home/technical-resources/contact-us.html'>Contáctenos</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"lk":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/lk.gif","name":"Sri Lanka","phone":"<a href='/lk/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SA"},"sh":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sh.gif","name":"St. Helena","phone":"<a href='/sh/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"sr":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sr.gif","name":"Suriname","phone":"<a href='/sr/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"sj":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sj.gif","name":"Svalbard and Jan Mayen Islands","phone":"<a href='/sj/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"sz":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sz.gif","name":"Swaziland","phone":"<a href='/sz/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"se":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/se.gif","name":"Sweden","phone":"<a href='/se/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"ch":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ch.gif","name":"Switzerland","phone":"<a href='/ch/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"sy":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sy.gif","name":"Syria","phone":"<a href='/sy/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":true,"registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"tw":{"defaultLanguage":"zt","name":"Taiwan | 台灣","phone":"<a href='/tw/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_TW"},"tj":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/tj.gif","name":"Tajikistan","phone":"<a href='/tj/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"tz":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/tz.gif","name":"Tanzania","phone":"<a href='/tz/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"th":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/th.gif","name":"Thailand","phone":"<a href='/th/en/home/technical-resources/contact-us.html?supportType=OS#ordersupport'>Order Support</a>","signInHidden":true,"registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SEA"},"tg":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/tg.gif","name":"Togo","phone":"<a href='/tg/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"to":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/to.gif","name":"Tonga","phone":"<a href='/to/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":true,"registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"IPAC_AA"},"tt":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/tt.gif","name":"Trinidad and Tobago","phone":"<a href='/tt/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"tn":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/tn.gif","name":"Tunisia","phone":"<a href='/tn/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"tr":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/tr.gif","name":"Turkey","phone":"<a href='/tr/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"tm":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/tm.gif","name":"Turkmenistan","phone":"<a href='/tm/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"tc":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/tc.gif","name":"Turks and Caicos Islands","phone":"<a href='/tc/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ug":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ug.gif","name":"Uganda","phone":"<a href='/ug/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ua":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ua.gif","name":"Ukraine","phone":"<a href='/ua/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ae":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ae.gif","name":"United Arab Emirates","phone":"<a href='/ae/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"uk":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gb.gif","name":"United Kingdom","phone":"<a href='/uk/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"quickLinkIndex":"6","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"us":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/us.gif","name":"United States","signInHidden":"","registerHidden":"","euCountry":"","quickLinkIndex":"7","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar3.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"//www.unitylabservices.com","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"NA"},"um":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/um.gif","name":"United States Minor Outlying Islands","phone":"<a href='/um/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":true,"registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"uy":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/uy.gif","name":"Uruguay","phone":"<a href='/uy/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"uz":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/uz.gif","name":"Uzbekistan","phone":"<a href='/uz/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"va":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/va.gif","name":"Vatican City State (Holy See)","phone":"<a href='/va/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ve":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ve.gif","name":"Venezuela","phone":"<a href='/ve/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"vn":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/vn.gif","name":"Vietnam","phone":"<a href='/vn/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SEA"},"vg":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/vg.gif","name":"Virgin Islands (British)","phone":"<a href='/vg/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"vi":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/vi.gif","name":"Virgin Islands (U.S.)","phone":"<a href='/vi/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"eh":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/eh.gif","name":"Western Sahara","phone":"<a href='/eh/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ye":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ye.gif","name":"Yemen","phone":"<a href='/ye/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"zm":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/zm.gif","name":"Zambia","phone":"<a href='/zm/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"zw":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/zw.gif","name":"Zimbabwe","phone":"<a href='/zw/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""}}; </script> <script type="text/javascript" src="/store/global-header-footer-static/tf/js/footer-base.min.468bd07150dbbf.js" async></script> <script id="minicartScript" src="/store/minicartv3/minicart.js"></script> <script id="identityGlobal" src="/account-center/scripts/identityGlobal.min.js"></script>  <script data-inline-file-name='sec-assets-redirect.min.js' data-inline-site='tf'>/* Hash: 468bd07150dbbf Source: /tf/js/dist/sec-assets-redirect.min.js */ !function(e){let t=document.querySelectorAll("a[href^='https://sec-assets']");for(var n=0;n<t.length;n++)t[n].setAttribute("target","_blank"),t[n].addEventListener("click",function(t){t.preventDefault(),o(t,e(this))});function o(t,n){storageAssets=function(){var e,t,n,o=[],a={},s=0,i=document.getElementsByTagName("body")[0];function l(){if(0===s){if(!window.environmentURL)return!1;e="https://"+window.location.host,(t=!0)?(s=1,r()):(s=5,(n=document.createElement("iframe")).src=e+"/shared-static/support/_lt.localStorage.html",n.style.display="none",n.onload=function(){s=1,r()},n.onerror=function(){s=9},i.appendChild(n),window.attachEvent?window.attachEvent("message",d):window.addEventListener("message",d,!1))}}function d(e){if(e&&e.data&&"string"==typeof e.data){var t=e.data.split(":"),n=e.origin,o=decodeURIComponent(t[0]),s=decodeURIComponent(t[1]),i=(decodeURIComponent(t[2]),decodeURIComponent(t[3]));-1!==n.indexOf("thermofisher.")&&c(i,a[o+":"+s])}}function c(e,t){e?"lsFailure"===e&&(e=!1):e=null,t&&t(e)}function r(){for(var e,t=0;t<o.length;t++)u((e=o[t]).action,e.key,e.value,e.callback)}function u(i,d,r,u){if(l(),1!==s)o.push({action:i,key:d,value:r,callback:u});else if(t){var m=null;try{m=d&&r?window.localStorage[i](d,r):d?window.localStorage[i](d):window.localStorage[i]()}catch(e){m="lsFailure"}c(m,u)}else{var g="ls-"+i+":"+Math.floor(1e6*Math.random()+1),p=g;d&&(p+=":"+encodeURIComponent(d),r&&(p+=":"+encodeURIComponent(r))),a[g]=u,n.contentWindow.postMessage(p,e)}}return{getItem:function(e,t){u("getItem",e,null,t)},setItem:function(e,t,n){u("setItem",e,t,n)}}}();var o,a,s=window.location.hostname,i="/"+_lt.user.displayIso+"/"+_lt.user.displayLang+"/syndicated-content/snippets/terms-secure-file.html",l=s.split("thermofisher.")[1],d="https://"+s+"/api-gateway/tfdocs/signedurl?objectKey="+n.attr("href").split(l+"/")[1],c=localizedStrings.ACCEPTANCE||"Acceptance to Terms of Use",r=localizedStrings.BTN_AGREE||"Agree",u=localizedStrings.BTN_DISAGREE||"Disagree",m=localizedStrings.SUBMIT_ERROR_SERVER||"Error - please try again.";storageAssets.getItem("secureFileAccepted",function(n){if(_lt.user.isLoggedIn)if(e.ajax({type:"GET",url:d,dataType:"text",cache:!1,async:!1,success:function(e){try{o=JSON.parse(e)}catch(e){console.log("Error in Parsing Json File")}},error:function(e,t,n){},complete:function(){null!=o&&void 0!==o?a=o.success.preSignedURL:console.log("Error in getting presigned URL")}}),null!=n&&"Y"==n)window.open(a,"_blank"),_lt.user.initLoginChecks();else{var s=e('<div class="modal hide modal-loading modal-secure-file-acceptance"><div class="modal-header"><button type="button" class="close" data-dismiss="modal" aria-hidden="true">×</button><h3>'+c+'</h3></div><div class="modal-body"><div class="text-center"><span class="loading-wheel loading-wheel-md"></span></div></div><div class="modal-footer"><button type="button" class="btn btn-disagree" data-dismiss="modal">'+u+'</button><a href="'+a+'" target="_blank" class="btn btn-primary btn-agree">'+r+"</a></div></div>"),l=e(".modal-body",s);e(".btn-disagree",s),e(".btn-agree",s).click(function(){storageAssets.setItem("secureFileAccepted","Y"),s.modal("hide"),s.remove(),_lt.user.initLoginChecks()}),s.on("hidden",function(){s.remove()}),e.get(i).success(function(e){l.html(e),s.removeClass("modal-loading")}).error(function(e){l.text(m)}),s.appendTo("body"),s.modal({backdrop:"static",keyboard:!1}),s.modal("show"),e("body").append("<style>.modal-secure-file-acceptance.modal-loading .modal-footer { display:none; }</style>"),t.stopImmediatePropagation()}else invokeOidcLogin(window.location.href)})}}(window.$j);</script> <script type="text/javascript" id="dmOffers" src="/dm-offers/offers.min.js" defer></script> <script type="text/javascript"> var preferences = document.cookie.match(new RegExp("(^| )notice_preferences=([^;]+)")); var deployLaunch = ((preferences && parseInt(preferences[2] || 0) > 0) || (!true && !window.location.href.includes("eta=true"))); if (!document.querySelector("#tagmanager") && deployLaunch && !(/how-cookies-are-used|privacy-policy/i.test(window.location.href))) { var script = document.createElement("script"); script.id = "tagmanager"; script.src = "https://assets.adobedtm.com/launch-ENeecb77f1160a4928a492ff040f7110c7.min.js"; script.type = "text/javascript"; document.head.appendChild(script); } else { var script = document.createElement("script"); script.src = "https://assets.adobedtm.com/7e08552ade3f/1a8047d2b483/launch-f46125d37e44.min.js"; script.type = "text/javascript"; document.head.appendChild(script); } </script>  <script data-inline-file-name='digitalDataAnalyticsListener.min.js' data-inline-site='tf'>/* Hash: 468bd07150dbbf Source: /tf/js/dist/digitalDataAnalyticsListener.min.js */ !function(){"use strict";window.digitalDataAnalyticsListener={initted:!1,init:function(){this.emailCampaignRecord()},emailCampaignRecordFired:!1,emailCampaignRecord:function(){if(0!=digitalData.merchandisingDataInitted)if(1!=this.emailCampaignRecordFired){var i=digitalData.merchandising,a=i.emid;void 0!==a&&null!=a&&""!=a?(console.log("digitalDataAnalyticsListener: Email campaign tracking recored about to fire"),$.ajax({headers:{"Content-Type":"application/json; charset=utf-8"},url:environmentURL.DATAHUB+"/datahub/api/v1/datalayer/record",dataType:"json",type:"POST",contentType:"application/json",data:JSON.stringify({hit_domain:window.location.hostname,referrer:i.referrer,analyticsVisitorid:i.analyticsVisitorID,marketingCloudid:i.marketingCloudVisitorID,dmOfferSessionid:i.sessionId,s_vi_low:i.s_vi_low,s_vi_high:i.s_vi_high,icid:i.icid,cid:i.cid,emid:i.emid,amoid:i.amoid,formid:digitalData.form,gigya_uid:digitalData.user.gigyaId}),success:function(i){console.log("digitalDataAnalyticsListener: Success",i),digitalDataAnalyticsListener.emailCampaignRecordFired=!0},error:function(i){console.log("digitalDataAnalyticsListener: Data not persisted",i),digitalDataAnalyticsListener.emailCampaignRecordFired=!1}})):console.log("digitalDataAnalyticsListener: Email campaign tracking NOT triggered as emid is not present")}else console.log("digitalDataAnalyticsListener: Email campaign record was successfully fired once before");else console.log("digitalDataAnalyticsListener: Not ready to fire email campaing record")}}}(),window.digitalDataAnalyticsListener.init();</script> <script id="chatLauncher" src="//chat-api.thermofisher.com/search/chat-launcher/chat-launcher.js" defer></script>  <div id="landscape-banner"> <div class="interactoffers"> <div class="dynamic-offer" id="tf-headerfooter-lb" data-placement-type="headerfooter" data-placement-code="lb" data-default-snippet=""> </div> </div> </div> </div> </footer> </div> <form id="productForm" name="productForm" method="POST"></form>  <form action="&CID=&ICID=" method="POST" id="IVGNaddToCartForm"> <input id="IVGNAddToCartXML" name="AddToCartXML" type="hidden" value="" /> </form> <iframe style="display:none;" id="addToFavoritesTarget">AddToFavs result goes here(DO NOT DELETE ME!)</iframe> <div id="pop-add" class="mag-dialog on-top" style="display: none;"> <div class="dialog-content" style="padding-bottom: 20px;"> <button class="close pop-add-cls" type="button">Close X</button> <h3 style="margin-bottom: 0px;"> Your item<span id="pop-plural" style="display: none; float: none;">s have</span><span id="pop-sing" style="float: none;"> has</span> been added! </h3> <br /> <input type="button" class="pop-b button primary-button core-view" value="View Cart" /> <input type="button" class="button commerce-button checkout pop pop-b core-checkout" value="Checkout" /> </div> </div>  <script> var _savedJQuery = window.$; window.jQuery = window.$j; </script> <script> window.$ = _savedJQuery; window.jQuery = _savedJQuery; </script> <script> $m.assayType = ''; </script>  <div style="display:none" id="debugMessage"> Host server : magellan-search-blue-5c9c5c4749-vpmkj:80/100.66.78.144:80. <br>git-commit: d22414ba47b22cc02ffc24003f0e179da61511a6 <br>git-url: https://github.com/thermofisher/magellan-search <br>git-branch: release/2.21.0-Offline </div> <script> $m.translations = {"antibody.serp.filter.ptm":"PTM","antibody.serp.footer.talk":"Talk to a specialist now","immunoassay.elisa.zero.results.reason.one":"Spelling or typing errors. You can use the product search to modify your search.","antibody.pdp.documents":"Documents","antibody.pdp.productDetail.conjugate":"Conjugate","common.search.modal.faq.heading.success":"Thank you for your feedback","microbe.zero.results.reason":"Possible reasons that no Assays were found:","global.search.results.faqCard.feedback":"Provide Feedback on this Answer","global.search.secondaryResults.navigators.manualsAndProtocols.nav1":"Document Types","antibody.zero.results.other.subtype.two":"Zero results for \"{0}\" but we found \u003ca href\u003d\"{1}query/{0}\"\u003e{2} {3}\u003c/a\u003e and \u003ca href\u003d\"{4}query/{0}\"\u003e{5} {6}\u003c/a\u003e that match your search.","global.search.results.cmgtProdCard.specifications":"General Specifications","antibody.pdp.reference.zeroResultBtnTxt":"Cite this product","antibody.pdp.productDetail.elisa":"ELISA","common.wsp.tooltip.info":"Web orders only. Excludes Supply Centers.","global.search.filter.persona.allResults":"All Results","common.search.modal.search.heading":"What were you looking for?","antibody.pdp.reference.benchscilink":"View published figure on \u003cimg class\u003d\"benchsci-logo\" src\u003d\"/order/genome-database/assets/img/benchsci-logo.svg\"\u003e\u003cimg src\u003d\"/content/dam/LifeTech/Images/Header/jumpout-link.png\"\u003e","crispr.zero.results.contact":"GEMServices@thermofisher.com","global.search.results.genomicsHelperCard.productType":"Product Type","antibody.pdp.hero.viewOther.proteinFamilyPageExist":"View all {0} {1}s","elisa.sitemap.description":"ELISA (enzyme-linked immunosorbent assay) is a plate-based technique for detection and quantification of antibodies or proteins such as cytokines, chemokines, growth factors, hormones, and intracellular phosphorylated proteins.","global.search.results.probesStructureCard.casNameAndNumber":"CAS Name/Number","global.search.results.geneCard.entrezGeneID":"Entrez Gene ID","antibody.searchresults.rowheader.host":"Host","elisa.crossSellCard.select.antibody.forKit":"Select Antibodies for your kit","global.search.noResults.resources.requestMsds":"Request an MSDS","antibody.pdp.productDetail.cytotoxicityassay":"Cytotoxicity Assay","antibody.pdp.bioinformatics.proteinAliases":"Protein Aliases:","global.search.qty.invalid":"Please enter a quantity in the range of 1 to 9999.","global.search.results.faqCard.answerId":"Answer Id: {0}","serp.nav.tabs.isotype.controls":"Isotype Controls","global.search.results.handbookCard.resultType":"Molecular Probes Handbook","antibody.pdp.reference.less":"less ","elisa.pdp.hero.reference":" Reference","elisa.crossSellCard.find.exact.antibody":"Find the exact antibody for your Elisa kit.","global.search.results.probesStructureCard.resultType":"Chemical Structure","elisa.sitemap.titleprefix":"ELISA Kits","elisa.pdp.productdetails.speciesreported":"Species (reported)","serp.filter.lessText":"Less","elisa.searchresults.rowheader.timetoresult":"Time To Result","antibody.serp.compare.storage.conditions":"Storage Conditions","global.search.results.cmgtProdCard.supportDocuments":"Support Docs","global.search.button.configure":"Configure","serp.filtertext.displayname.species":"Species","global.search.noResults.needHelp.contactUs":"Contact Us","antibody.pdp.productDetail.chipassay":"ChIP assay","global.search.results.mediaFormulationCard.catNo":"Catalog #s","antibody.searchresults.rowheader.product":"Product","antibody.serp.compare.class.type":"Class / Type","antibody.searchresults.sop.save":"Save","global.search.results.probesStructureCard.viewMoreComponents":"View More","antibody.serp.compare.reference":"Reference","oligos.jpOligos.bulkUpload.uploadOptionsHeader":"Select the default options below to apply to your imported sequences.","antibody.tfp.desc.viewmore":"View more","antibody.pdp.productDetail.fluorescenceresonanceenergytransfer":"Fluorescence Resonance Energy Transfer ","info.tout.footer.createTxt":"Create","immunoassay.elisa.zero.results.other":"However, we found \u003ca href\u003d\"{0}\"\u003e{1} other\u003c/a\u003e results on the site","antibody.pdp.productDetail.westernblot":"Western Blot","global.search.noResults.heading":"No Results","global.search.results.vectorCard.resultType":"Vector Map","antibody.pdp.productDetail.readytouseimmunoassay":"Ready-To-Use Immunoassay","elisa.pdp.productdetails.genesymbol":"Gene symbol","global.search.results.geneCard.species":"Species","antibody.pdp.reference.mostrecent":"Most recent ","global.search.noResults.querySuggestionWithResults":"Search for: \"\u003ca href\u003d\"{0}\"\u003e{1}\u003c/a\u003e\" ({2} matches)","oligos.jpOligos.bulkUpload.pasteSequence":"Copy/Paste Upload","info.modal.header.sharedListdescmobile":"Shared lists are a new way to save products. Create \n a list for each of your projects to share with \n collaborators like your lab manager. Then \n select and buy products as a team. ","antibody.searchresults.row.with.numeric.figure":" figure","elisa.pdp.productdetails.productsize":"Product size","global.search.results.cmgtProdCard.price":"List Price","antibody.pdp.productDetail.immunogen":"Immunogen ","global.search.sharedList.addedTo":"Added to","serp.filtertext.displayname.host":"Host","crispr.searchresults.rowheader.species":"Species","antibody.pdp.productDetail.storagebuffer":"Storage buffer","global.search.button.saveToList":"Save to list","oligos.jpOligos.addOligo.delivery":"Delivery *","info.modal.header.sharedListdesc":"Shared lists are a new way to save products. Create a list for each of your projects to share \n with collaborators like your lab manager. Then select and buy products as a team.","global.search.results.citationCard.productUsage":"Product Usage","antigen.onboarding.message":"Adjust the sliders to select your desired sequence range","antibody.pdp.productDetail.Viewimmunogen":"View immunogen","common.search.modal.search.button.submit":"submit","info.modal.header.createsharedListDesc":"Click \"Save to list\" to create your first list, \n give it a name, and add the product. Access \n your shared lists in the Account link on \n Thermofisher.com. ","global.search.results.featuredResultCard.resultType":"Overview","support.search.techSupport.navigation.productFaqs":"Product FAQs","antibody.pdp.bioinformatics.uniProtID":"UniProt ID:","global.search.results.probesStructureCard.molWeight":"Molecular Weight","proteinnpeptide.sitemap.titleprefix":"Proteins \u0026 Peptides","antibody.searchresults.row.bestseller":"Best Seller","proteinnpeptide.sitemap.description":"Wide range of recombinant proteins, native proteins, and synthetic peptides for cell culture, functional studies and other immunoassays. Select a target to view all proteins.","oligos.jpOligos.bulkUpload.processingWait":"We are processing your request. This may take a few moments. Thank you for your patience.","antibody.searchresults.row.mobile.continue":"Continue","antibody.pdp.productDetail.immunohistochemistrypfafixed":"Immunohistochemistry (PFA fixed)","common.search.modal.faq.button.cancel":"cancel","support.search.techSupport.navigation.orderingAndWebFaqs":"Ordering \u0026amp; Web FAQs","common.search.modal.search.validation.required.feedback":"Please provide feedback","antibody.serp.spellcheck.singleSearchTextKeywordSingular":"\u003cspan class\u003d\"regWeight\"\u003eNo result for\u003c/span\u003e \u003cstrong\u003e{1}\u003c/strong\u003e. \u003cspan class\u003d\"regWeight\"\u003eShowing \u003cstrong\u003e{0} results\u003c/strong\u003e for\u003c/span\u003e {2}","antibody.pdp.footer.helpText":"Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.","antibody.pdp.productDetail.flowcytometry":"Flow Cytometry","global.search.results.genericContentCard.heading":"Buying Guide","serp.flt.srch.placeholder.brand":"Search Brand","serp.flt.srch.placeholder.conjugate":"Search Conjugate","antibody.tfp.subheader.targetinformation":"Target Information","support.search.techSupport.navigation.technicalReferenceLibrary":"Technical Reference Library","global.search.results.cmgtProdCard.numCitations":"View \u003cb\u003e{0}\u003c/b\u003e Citations ","antibody.pdp.productDetail.clone":"Clone","antibody.pdp.productDetail.form":"Form","global.search.noResults.additionalResource.content":"Looking for a \u003ca href\u003d\"/site/us/en/home/support/Certificate-of-Analysis-Request-Form.html\"\u003eCertificate of Analysis\u003c/a\u003e or a \u003ca href\u003d\"/site/us/en/home/support/MSDS-Request-Form.html\"\u003eMSDS\u003c/a\u003e?","global.search.results.msdsCard.resultType":"MSDS","oligos.jpOligos.messages.noProjects":"Please add one or more projects","antibody.pdp.commerceCard.dateTooltipMessage":"Items usually ship within 1 business day from the estimated availability date.","serp.filtertext.displayname.crossadsorbed":"Cross Adsorbed","antibody.pdp.productDetail.antibodiesbyimmunogen":"antibodies by immunogen","antibody.pdp.productDetail.affinitypurification":"Affinity Purification","antibody.pdp.productDetail.immunostaining":"Immunostaining","antibody.searchresults.row.mostfigures":"Most Figures","antibody.pdp.productDetail.inhibitionassays":"Inhibition Assays","antibody.searchresults.row.account.price.tooltip":"Your account price is the best price.","global.search.noResults.searchTips.heading":"Search Tips:","antibody.searchresults.row.mobile.select":"Select","unified.card.mirna":"miRNA mimics and inhibitors","oligos.jpOligos.addOligo.modificationsAndOptions":"Modifications and options","antibody.searchresults.row.mobile.done":"Done","global.button.sharedList.createTxt":"Create","antibody.pdp.hero.proteins.viewOther":"View all ({0}) {1} proteins","antibody.searchresults.tabheader.products":"Products","antibody.pdp.productDetail.expressionSystem":"Expression System","elisa.pdp.productdesc.have.you.cited.this.product":"Have you cited this product in a publication? ","antigen.searchresults.nosearchresults":"No search results","global.search.results.minipdp.manuls.heading":"Manuals \u0026 Product Inserts ","support.search.searchTips":"Search Tips","antibody.pdp.productDetail.activity":"Activity","serp.tabheader.searchby":"Search by","antibody.pdp.productDetail.blockingassay":"Blocking Assay","crispr.zero.results.contact.assistance":"for assistance.","antibody.pdp.productDetail.dotblot":"Dot blot","antibody.pdp.reference.citation":"citation","global.search.results.vectorCard.map":"Map","support.search.noResults.heading":"No Results","antibody.pdp.hero.dataSheets":"Datasheet","antibody.pdp.commerceCard.checkYourPrice":"Check your price","antibody.searchresults.row.guest.user.tooltip":"now to see your best price.","global.search.results.probesStructureCard.molFormula":"Molecular Formula","microbe.zero.results":"No results found","antigen.searchresults.rowheader.sequenceRange":"Sequence Range","antibody.pdp.productDetail.endotoxinconcentration":"Endotoxin concentration","serp.filtertext.displayname.new":"New","serp.filtertext.displayname.format":"Format","oligos.jpOligos.addOligo.baseCount":"Base Count","antibody.pdp.productDetail.species":"Species","antibody.searchresults.row.online.offer":"Online offer: ","oligos.jpOligos.addOligo.reverseComplementOligoName":"Reverse Complement Oligo Name *","antibody.pdp.productDetail.radioimmuneassays":"Radioimmune Assays","serp.panel.builder.adText.tryPB":"Try Panel Builder","global.search.results.itemsPerPage":"Results per page","antibody.pdp.imageGallery.dataGallery":"Data Gallery","antibody.pdp.reference.year":"Year","antibody.pdp.hero.viewOther":"View all ({0}) {1} antibodies","antibody.pdp.bioinformatics.entrezGeneID":"Entrez Gene ID:","antibody.pdp.productDetail.testedApplication":"Applications","global.search.results.assayCard.assayId":"Assay ID","antibody.searchresults.row.mobile.filter.results":"Filter results","antibody.pdp.productDetail.chipsequencing":"ChIP-sequencing","support.search.techSupport.navigation.allSupportDocs":"MSDS, COA \u0026amp; other Support Documents","antibody.serp.compare.references":"s","antibody.serp.filter.protein.name":"Protein Name","antibody.pdp.commerceCard.pdlt.2-4weeks":"2-4 Weeks","zrp.no.results":"No results for \"{0}\" in {1}","global.search.noResults.needHelp.detailedSearchTips":"Detailed Search Tips","antigen.searchresults.rangeText":"Select your sequence range","serp.flt.srch.placeholder.proteintarget":"Search Protein Target","serp.filtertext.displayname.proteintarget":"Protein Target","antigen.searchresults.resetsearchbtn":"Reset search","antibody.searchresults.rowheader.offer.ends":"Offer ends ","antibody.pdp.bioinformatics.processes":"Process(es)","antibody.pdp.footer.helpTitle":"We\u0027\u0027\u0027re here to help","antibody.pdp.productDetail.neutralization":"Neutralization","antibody.pdp.productDetail.tcellactivation":"T-Cell Activation","global.search.results.cmgtProdCard.productApplications.label":"Product Applications","antibody.serp.compare.antibody.form":"Antibody Form","antibody.pdp.productDetail.immunofluorescence":"Immunofluorescence ","global.search.results.dayCard.heading":"Learn more about","antibody.comparepage.compare":"Compare","global.search.results.msdsCard.msdsFiles":"MSDS Files","global.search.results.assayCard.productType":"Product Type","support.search.navigator.documentType.label.lull":"Limited Use Label Licenses","support.search.placeholder.tip.msds":"by catalog number or product name","antibody.serp.compare.concentration":"Concentration","unified.card.proteins":"Recombinant proteins and peptides","support.search.techSupport.navigation.contactOrderSupport":"Contact Order Support","crispr.zero.results.reason.two":"The products are listed under an alternate gene name. Try using Entrez Gene ID or a synonym as an identifier.","antibody.pdp.bioinformatics.header":"Bioinformatics","antibody.searchresults.row.advanced.verification":"Advanced Verification","antibody.pdp.productDetail.purification":"Purification","support.search.placeholder.tip.citationsAndReferences":"by catalog number or keyword","antibody.pdp.productDetail.immunoradiometricassay":"Immunoradiometric Assay","antibody.searchresults.rowheader.price.symbol":"CNY","elisa.pdp.productdetails.analyticalsensitivity":"Analytical sensitivity","support.search.navigator.documentType.label.all":"All Support Documents","antibody.pdp.productDetail.immunodiffusion":"Immunodiffusion","antibody.searchresults.row.load.more.results":"Load {0} more results","support.search.results.found":"[{0} matches]","antibody.searchresults.row.special.offer":"Special offer: ","antibody.serp.compare.target":"Target","support.search.placeholder.tip.mediaFormulations":"by catalog number","global.search.pagination.nextPage":"Next \u0026gt;","elisa.pdp.showLess.button":"Show Less","common.search.modal.faq.label.expectations.exceeded":"Exceeded","elisa.serp.createOwn.section":"Create Your Own ELISA","global.search.results.lullCard.lullFiles":"Limited Use Label Licenses","serp.loadmore.viewText":"Viewing {0} {1} {2}","oligos.jpOligos.addOligo.scale":"Synthesis Scale *","global.search.form.searchWithin.message":"Search Within","antibody.pdp.commerceCard.offerends":"Offer ends","global.search.error.heading":"An error occurred during search.","antibody.serp.filter.showLess.filters":"Show Less","antibody.pdp.reference.citations":"citations","common.search.modal.faq.validation.invalid.email":"Please enter a valid email address","antibody.serp.compare.cross.adsorption":"Cross Adsorption ","antibody.serp.compare.immunogen":"Immunogen","oligos.jpOligos.bulkUpload.templateDownloadButton":"Download Sequence Template","antibody.sitemap.primary.titleprefix":"Primary Antibodies","antibody.searchresults.row.best.price.tooltip":"This is your best price.","common.search.modal.faq.label.body":"Feedback on FAQ:","global.search.noResults.additionalResource.heading":"Additional Resources:","global.search.results.geneCard.resultType":"Gene","support.search.navigator.documentType.label.brochures":"Product Literature","antibody.pdp.reference.see":"See","microbe.zero.results.contact.three":"for direct assistance. In most cases, our service desk will respond within 1 business day.","global.search.sortingOptions.dateSort.descending":"Newest First","antibody.pdp.productDetail.contains":"Contains","global.search.enterListName.watermark":"Enter list name","oligos.jpOligos.messages.emptyProject":"One or more projects do not contain any oligos","antibody.searchresults.row.cat":"Cat #","support.search.navigator.documentType.label.coa":"Certificates of Analysis","elisa.pdp.productdetails.labelordye":"Label or dye","oligos.jpOligos.common.buttons.newProject":"New Project","antibody.searchresults.row.special.price.tooltip":"Special offer is your best price.","serp.filtertext.displayname.conjugate":"Conjugate","antibody.serp.filter.brand":"Brand","global.search.results.manualCard.catNo":"Cat. No.","antibody.pdp.productDetail.aminoacidsequence":"Amino acid sequence","antibody.searchresults.row.online.price":"Online price: ","serp.flt.srch.placeholder.cellline":"Search Cell Line","serp.nav.tabs.proteins.peptides":"Proteins and Peptides","antibody.comparepage.print":"Print","global.search.results.posterCard.resultType":"Scientific Poster","antibody.pdp.productDetail.purity":"Purity","antibody.pdp.commerceCard.contactus":"Contact Us","antibody.pdp.productDetail.relativeexpression":"Relative expression","elisa.pdp.productdetails.timetoresult":"Time-to-result","global.search.results.manualCard.resultType":"Manual / Product Insert","global.search.results.protocolCard.resultType":"Experiment Protocol","antibody.zero.results.other":"Zero results for \"{0}\" but we found \u003ca href\u003d\"{1}\"\u003e{2} other results\u003c/a\u003e on the site.","global.search.noResults.resources.requestCoa":"Request a Certificate of Analysis","global.search.results.citationCard.id":"ID","antibody.pdp.commerceCard.pdlt.1-2weeks":"1-2 Weeks","support.search.form.searcharea.refine.label":"Refine your search","global.search.error.body":"Please review your keyword and try again.","antibody.pdp.productDetail.immunomicroscopy":"Immunomicroscopy","support.search.placeholder.tip.vectors":"by catalog number or product name","crispr.zero.results.reason":"Possible reasons that no CRISPR Guide RNA were found:","unified.card.isotype":"Isotype controls","serp.flt.srch.placeholder.clone":"Search Clone","antibody.serp.filter.antibody.form":"Antibody Form","global.search.button.quickProductInfo":"Quick Product Info","common.search.modal.faq.validation.required.feedback":"Please provide feedback","antibody.pdp.commerceCard.quantity":"Quantity","antibody.pdp.productDetail.storageconditions":"Storage conditions","antibody.serp.compare.clone":"Clone","crispr.searchresults.rowheader.assayId":"Assay ID","global.search.results.manualCard.download":"Download","oligos.jpOligos.bulkUpload.fileUpload":"DNA File Upload","elisa.pdp.productdetails.proteinfamily":"Protein family","antibody.pdp.hero.references":"{0} Reference{1}","antibody.pdp.productDetail.peptidearray":"Peptide Array","antibody.pdp.imageGallery.benchsciImageText":"View full figure on","common.search.modal.faq.label.expectations.notMet":"Not Met","global.search.results.genomicsHelperCard.resultType.mirna":"miRNA Mimic, Inhibitor and Assay","antibody.serp.compare.conjugate":"Conjugate","global.search.noResults.resources.heading":"Resources","oligos.jpOligos.addProject.addOligo":"Add Oligo","antibody.pdp.productDetail.crossadsorption":"Cross Adsorption","unified.card.antibody":"Antibodies","antibody.serp.singleSearchText":"{0} results","unified.card.taqman":"TaqMan™ assays and arrays","info.modal.header.learnMoresharedList":"Learn More","global.search.results.dayCard.resultType":"Overview","oligos.jpOligos.basicEntry.help":"Help","antibody.pdp.footer.helpButton":"Contact tech support","global.search.results.brochureCard.version":"Version","elisa.searchresults.rowheader.sensitivity":"Sensitivity","antibody.pdp.commerceCard.pendingTooltipChinaSCMessage":"We can\u0027t get availability information for you right now. Items usually ship with the next Supply Center shipment.","crispr.searchresults.rowheader.price":"Price (USD)","oligos.jpOligos.bulkUpload.invalidFileFormat":"Invalid file type - please save file as .xls, .csv or .txt and upload again.","elisa.pdp.productdetails.assaykitformat":"Assay kit format","support.search.placeholder.tip.spectra":"by catalog number","global.search.results.genericContentCard.resultType":"Buying Guide","serp.filtertext.displayname.producttype":"Product Type","antibody.pdp.productDetail.antibodyform":"Antibody Form","antibody.pdp.commerceCard.availability.text":"Estimated availability date: ","global.search.results.faqCard.answer":"Answer","antibody.pdp.productDetail.immunoprecipitation":"Immunoprecipitation","antibody.comparepage.addtocart":"Add to cart","antibody.pdp.productDetail.Viewall":"View all","antibody.serp.comapre.not.in.region":"Product not available in your region","antibody.pdp.reference.authors":"Authors","antibody.pdp.productDetail.targetInformation":"Target Information","oligos.jpOligos.common.buttons.import":"Import","common.search.modal.search.validation.invalid.email":"Please enter a valid email address","microbe.zero.results.contact.one":"Please contact","antibody.serp.filter.protein.target":"Protein Target","microbe.zero.results.reason.two":"The assay is listed under an alternate gene/protein name. Try searching for synonyms.","unified.card.secondary":"Secondary antibodies","global.search.results.featuredResultCard.heading":"Featured Product","antibody.pdp.hero.publishedFigures":"{0} Published Figure{1}","antibody.pdp.productDetail.forresearchuseonlynotforuseindiagnosticproceduresnotforresalewithoutexpressauthorization":"For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.","info.modal.header.collaboratesharedListHeader":"Collaborate","antibody.searchresults.row.reference":" Reference","global.search.results.cmgtProdCard.contactUs.Url":"http://template.day.fqdn/site/us/en/home/Global/Contact-Us.html","global.search.noResults.searchTips.list":"\u003cli\u003eRe-check spelling of search word(s).\u003c/li\u003e\u003cli\u003eSearch with fewer words. For example, instead of searching for \"Countess Automated Cell Counter\", try searching for \"Countess\".\u003c/li\u003e\u003cli\u003eRemove any special characters from catalog numbers. For example, instead of searching for \"XYZ-123\", try searching for \"XYZ123\".\u003c/li\u003e","oligos.jpOligos.addProject.researcherName":"Researcher Name *","antibody.pdp.commerceCard.performanceGuarantee":"Performance Guarantee","oligos.jpOligos.basicEntry.mainHeading":"Custom DNA Oligos","antibody.searchresults.rowheader.clearall":"Clear all","antibody.pdp.imageGallery.validationinfo":"validation info.","global.search.sortingOptions.dateSort.ascending":"Oldest First","antibody.serp.filter.product.type":"Product Type","microbe.zero.results.reason.three":"Spelling or typing errors. You can use the search above to modify your search,","global.search.results.cmgtProdCard.ratings.heading":"User Ratings","global.search.results.cmgtProdCard.seeAll":"See all","antibody.pdp.productDetail.immunohistochemistryfrozen":"Immunohistochemistry (Frozen)","elisa.pdp.productdetails.genealiases":"Gene aliases","antibody.searchresults.sop.price":"Price","crispr.searchresults.rowheader.gene":"Gene","antibody.searchresults.row.sop.online.price":"Online exclusive","antibody.pdp.reference.species":"Species","elisa.pdp.hero.about.this.kit.rigorousvalidation":"Rigorous validation","antibody.pdp.productDetail.publishedSpecies":"Published species","antibody.searchresults.row.with.numeric.figures":" figures","elisa.crossSellCard.customAssay.service":"Custom Assay Services","antibody.serp.footer.desc1":"Searching for an antibody we don\u0027\u0027t offer? We make custom antibodies for specific targets, species and applications.","antibody.serp.footer.desc2":"More than 18,000 custom antibodies created so far.","global.search.results.lullCard.resultType":"Limited Use Label License","oligos.jpOligos.deleteOligo.title":"Confirmation","antibody.pdp.productDetail.rrid":"RRID","antibody.pdp.productDetail.competitionassay":"Competition Assay","antibody.pdp.productDetail.agglutination":"Agglutination","common.search.modal.faq.label.expectations":"Expectations:","serp.filtertext.displayname.tag":"Tag","global.search.noResults.resources.realTimePCRCatalog":"Looking for TaqMan\u0026reg; Assay or Silencer\u0026reg; siRNA products? View our \u003ca href\u003d\"http://template.day.fqdn/site/us/en/home/Products-and-Services/Applications/Nucleic-Acid-Amplification-and-Expression-Profiling/Real-Time-PCR.html\"\u003eReal-Time PCR catalog\u003c/a\u003e.","elisa.pdp.productdetails.homogenousnowash":"Homogenous (no wash)","oligos.jpOligos.bulkUpload.field.scale":"Synthesis Scale *","antibody.serp.filter.laser.compatibility":"Laser Compatibility","antibody.searchresults.rowheader.expressionSystem":"Expression System","antibody.pdp.productDetail.hemagglutinationassay":"Hemagglutination Assay","antibody.pdp.productDetail.immunohistochemistryparaffin":"Immunohistochemistry (Paraffin) ","antibody.searchresults.rowheader.compare":"Compare","serp.filtertext.displayname.expressionsystem":"Expression System","global.search.results.mediaFormulationCard.resultType":"Media Formulation","elisa.crossSellCard.shopFor.antibody":"Shop for Antibodies","global.search.results.genomicsHelperCard.find":"Find {0} that match your search term \"\u003ca href\u003d\"{1}\"\u003e\u003cstrong\u003e{2}\u003c/strong\u003e\u003c/a\u003e\"","antibody.serp.filter.application":"Application","antibody.serp.compare.published.application":"Published Application","support.search.navigator.documentType.label.citations":"Citations \u0026amp; References","oligos.jpOligos.common.buttons.cancel":"Cancel","antibody.zero.results.reason.one":"Spelling or typing errors. You can use the product search to modify your search.","antibody.pdp.imageGallery.figure":"FIGURE","antibody.pdp.commerceCard.pendingTooltipMessage":"We can\u0027t get availability information for you right now. Items usually ship within 1 business day of when they become available.","antibody.pdp.productDetail.proteineassaysandanalysis":"Proteine Assays and Analysis","elisa.pdp.hero.techsupport":"Tech Support","antibody.pdp.reference.dilution":"Dilution ","global.search.results.cmgtProdCard.description":"Description","oligos.jpOligos.addOligo.minMaxOligoSequence":"Please enter a minimum of 7 and maximum of 30. Please make sure that there are no spaces before, after, or inside the sequence. U/I/F/E/O/Z are not allowed.","antibody.pdp.productDetail.lateralflow":"Lateral Flow","global.search.pagination.previousPage":"\u0026lt; Prev","antibody.pdp.productDetail.target":"Target","elisa.pdp.productdetails.detectorantibodyconjugate":"Detector antibody conjugate","antibody.zero.results.browse.all":"Browse all ","antibody.searchresults.rowheader.results":" results","antibody.pdp.commerceCard.requestBulkOrCustomFormat":"Request bulk or custom format","antibody.pdp.productDetail.tag":"Tag","antibody.zero.results.other.one":"Zero results for \"{0}\" but we found \u003ca href\u003d\"{1}\"\u003e{2} other result\u003c/a\u003e on the site.","antibody.pdp.imageGallery.benchsci.disclaimer2":"Disclaimer","antibody.pdp.imageGallery.benchsci.disclaimer1":"By clicking this image or link above, you will be redirected to the Benchsci website. ","support.search.techSupport.navigation.contactProductSupport":"Contact Product Support","elisa.pdp.productdetails.unitproid":"UniProt ID","antibody.pdp.productDetail.orthoganalmethod":"Orthoganal method","antibody.pdp.commerceCard.catalog":"Catalog # ","global.search.noResults.youSearchedFor":"\u003cstrong\u003eSearch for:\u003c/strong\u003e \u003ch1\u003e${query}\u003c/h1\u003e \u003cem\u003e(0 matches)\u003c/em\u003e","antibody.serp.filter.clear.filters":"Clear","antibody.serp.compare.host.isotype":"Host/Isotype","antibody.pdp.productDetail.viewmore":"View more","support.search.techSupport.navigation.training":"Training","serp.filtertext.displayname.productgrade":"Product Grade","global.search.results.cmgtProdCard.resultType":"Catalog Product","common.search.modal.search.label.body":"*Please provide feedback to help improve our search:","support.search.placeholder.tip.structures":"by catalog number or product name","global.search.results.found":"You searched for: ","antibody.pdp.productDetail.independentantibody":"Independent antibody","antibody.pdp.imageGallery.benchsci.disclaimerMessage":"Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.","global.search.results.faqCard.askNewQuestion":"Ask a New Question","antibody.pdp.productDetail.hostIsotype":"Host/Isotype","antibody.pdp.imageGallery.advancedVerification":"Advanced Verification","global.search.results.geneCard.aliases":"Aliases","antibody.serp.compare.tested.applications.dilution":"Tested Applications / Dilution","antibody.serp.compare.contains":"Contains","immunoassay.elisa.zero.results.reason.two":"The protein target is listed under an alternate gene/protein name. Try searching for synonyms.","secondary.sitemap.description":"Secondary antibodies for fluorescent, colorimetric, and chemiluminescent detection. Wide selection of antibodies for Western blot, IHC, ICC/IF, Flow Cytometry \u0026 ELISA. Select a target species to view all formats.","global.search.results.cmgtProdCard.catNo":"Catalog #","oligos.jpOligos.addOligo.oligoNameMessage":"You may enter up to 30 single-byte alphanumeric characters, including (,), -, _, and spaces.","global.search.button.supportDocuments":"Support Documents","global.search.filter.productAttributeFilters":"PRODUCT FILTERS","antibody.searchresults.rowheader.remove":"Remove","antibody.pdp.relatedAntibodiesHeader":"Related Antibodies","oligos.jpOligos.bulkUpload.uploadOptionsDescription":"Selected options will be applied to all \u003cu\u003eblank\u003c/u\u003e entries of the spreadsheet and will not overwrite any existing spreadsheet selections.","serp.filtertext.displayname.antibodyform":"Antibody Form","global.search.secondaryResults.navigators.faq.nav1":"Applications","global.search.secondaryResults.navigators.faq.nav3":"Brands","antibody.searchresults.tabheader.antigens":"Epitopes","antibody.searchresults.row.figure":"figure","global.search.secondaryResults.navigators.faq.nav2":"Product Categories","antibody.pdp.hero.textProtocols":"Protocols","antibody.pdp.productDetail.viewless":"View less","antibody.serp.filter.protein.length":"Protein Length","info.tout.footer.exportTxt":"Export","antigen.searchresults.nosearchresultsmsg":"There are no antigen sequence ranges that match your search. Try resizing the end points in your range.","elisa.pdp.showMore.button":"Show More","elisa.crossSellCard.requestQuote":"Request a quote","serp.filtertext.displayname.researcharea":"Research Area","antibody.pdp.productDetail.viewadditionalformats":"View additional formats","antibody.serp.filter.host":"Host","antibody.pdp.commerceCard.checkYourPriceAndAvailability":"Check your price \u0026 availability","antibody.pdp.reference.journal":"Journal ","global.search.results.cmgtProdCard.contactUs":"Contact Us","info.modal.header.collaboratesharedListDesc":"You can invite collaborators like your lab \n manager or procurement staff to any shared \n list. They can add more items, leave \n comments and complete the final purchase. ","antibody.zero.results":"Zero Results.","antibody.pdp.panelBuilder.videoHeading":"How to use the Panel Builder","serp.filtertext.displayname.recombinant":"Recombinant","antibody.pdp.documents.msds":"Material safety data sheets (MSDS)","unified.card.gene":"Branched DNA gene expression assays","elisa.pdp.productdetails.proteinaliases":"Protein aliases","antibody.pdp.productDetail.knockdown":"KnockDown","antibody.pdp.imageGallery.testingData":"Testing Data","serp.filtertext.displayname.adv.verification":"Adv. Verification","crispr.zero.results.reason.four":"The product has been discontinued.","oligos.jpOligos.addOligo.complementOligo":"Complement Oligo","secondary.sitemap.titleprefix":"Secondary Antibodies","antibody.pdp.footer.performanceGuaranteeButton":"Learn more","info.modal.header.exportsharedListDesc":"Export your list as a spreadsheet for \n easy documentation or hand off to your lab’s \n designated buyer. ","antibody.pdp.imageGallery.relativeexpression":"Relative expression","antibody.searchresults.rowheader.application":"Application","serp.filtertext.displayname.clonality":"Clonality","antibody.pdp.commerceCard.productnotavailableinyourregion":"Product not available in your region","common.search.modal.search.button.cancel":"cancel","info.tout.footer.collaborateTxt":"Collaborate","unified.card.sirna":"siRNA","common.search.modal.faq.label.email":"Email Address:","global.search.results.brochureCard.download":"Download","antibody.serp.compare.tested.species.reactivity":"Tested Species Reactivity","global.search.results.citationCard.resultType":"Citations \u0026amp; References","antibody.pdp.productDetail.insituhybridization":"In Situ Hybridization","oligos.jpOligos.bulkUpload.templateDownloadHeader":"Click below to download the Excel template to your local computer","global.search.results.assayCard.resultType":"Assay","antibody.pdp.hero.techSupport":"Tech Support","antibody.serp.filter.target.class":"Target Class","support.search.techSupport.navigation.events":"Events","unified.card.crispr":"CRISPR guide RNA","flow.cytometry.search.text":"Target, gene symbol","support.search.noResults.noResultsFoundForQuery":"We did not find results for: \u003cstrong\u003e${query}\u003c/strong\u003e in \u003cstrong\u003e${supportSearchArea}\u003c/strong\u003e.","antibody.serp.filter.clone":"Clone","antibody.searchresults.row.price.not.available":"Price not available","antibody.serp.singleSearchTextKeywordSingular":"{0} result","common.search.modal.faq.validation.required.email":"Please provide an email address","global.search.button.addToCart":"Add To Cart","global.search.results.cmgtProdCard.miniPdp.heading":"Product Detail","elisa.serp.notFinding.section":"Not finding what you\u0027re looking for?","elisa.pdp.productdetails.intraassaycv":"Intraassay CV","antibody.pdp.productDetail.rnaimmunoprecipitation":"RNA Immunoprecipitation","antibody.serp.compare.description":"For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.","oligos.jpOligos.bulkUpload.pasteSequenceDescription2":"","oligos.jpOligos.bulkUpload.pasteSequenceDescription1":"Please enter sequence individually, one record per line, separated by commas, with no space after the comma.","antibody.pdp.productDetail.miscellaneous":"Miscellaneous","antibody.serp.compare.storage.buffer":"Storage Buffer","elisa.pdp.hero.technicalguideprotocol":"Technical guide \u0026 protocol","antibody.pdp.productDetail.productSpecificationHeader":"Product Specific Information","antibody.pdp.productDetail.productspecifications":"Product Specifications","elisa.pdp.bioinformatics.proteinAliases":"Protein Aliases","serp.filtertext.displayname.application":"Application","global.search.listName.invalid":"Please enter a different list name that does not include the following: ?,/,\\,%,^,!","support.search.techSupport.navigation.instrumentRepair":"Instrument Repair","elisa.pdp.productdetails.proteinsubtype":"Protein subtype","oligos.jpOligos.common.buttons.addToCart":"Add To Cart","oligos.jpOligos.addProject.project":"Project","immunoassay.elisa.zero.results":"Zero Results.","common.search.results.catalogNumbers.label":"Catalog #s","serp.filtertext.displayname.uniprotid":"Uniprot ID","support.search.navigator.documentType.label.manualsAndProtocols":"Manuals \u0026amp; Protocols","serp.filtertext.displayname.proteinlength":"Protein Length","global.search.results.orderingWebFaq.heading":"Ordering \u0026amp; Web FAQ","antibody.pdp.hero.viewDetails":"View Details","serp.filter.moreText":"More","antibody.comparepage.disclaimer":"For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.","support.search.techSupport.navigation.manualsAndProtocols":"Manuals \u0026amp; Protocols","antibody.pdp.productDetail.control":"Control","antibody.serp.compare.expression.system":"Expression System","antibody.pdp.productDetail.concentration":"Concentration","microbe.zero.results.reason.four":"The Assay ID you entered does not match the species you selected. Note that you do not need to select a species to search by Assay ID.","serp.filtertext.displayname.proteinname":"Protein Name","antibody.pdp.productDetail.speciesReactivity":"Species Reactivity","antibody.pdp.suggestedSecondaryAntibodyHeader":"Suggested Secondary Antibodies","antibody.searchresults.tabheader.images":"Images","antibody.pdp.productDetail.molecularweight":"Molecular weight","control.sitemap.titleprefix":"Isotype Controls","oligos.jpOligos.addOligo.optional":"(optional)","antibody.searchresults.row.mostfigures.references":"Most Figures and References","global.search.results.coaCard.catNo":"Catalog #","antibody.pdp.commerceCard.pricenotavailable":"Price not available","antibody.searchresults.rowheader.figures":"Figures","oligos.jpOligos.common.buttons.bulkUpload":"Bulk Upload","elisa.pdp.productdetails.sampletypevolume":"Sample type/volume","antibody.pdp.productDetail.class":"Class","support.search.placeholder.tip.orderingWebFaq":"by keyword","antibody.pdp.productDetail.westernblotagglutination":"Western Blot (Agglutination)","antibody.comparepage.share":"Share","antibody.pdp.imageGallery.published.figure.supplied.by":"Published figure supplied by","antibody.serp.singleSearchTextKeywordPlural":"{0} results","antibody.pdp.imageGallery.antibodyTestingData":"Antibody Testing Data","support.search.placeholder.tip.coa":"by lot number or catalog number","antibody.pdp.commerceCard.availability.pending":"Pending","antibody.serp.filter.less.filters":"Less","antibody.pdp.productDetail.monoclonal":"Monoclonal","global.search.noResults.needHelp.heading":"Need Help?","antibody.serp.spellcheck.singleSearchTextKeywordPlural":"\u003cspan class\u003d\"regWeight\"\u003eNo results for\u003c/span\u003e \u003cstrong\u003e{1}\u003c/strong\u003e. \u003cspan class\u003d\"regWeight\"\u003eShowing \u003cstrong\u003e{0} results\u003c/strong\u003e for\u003c/span\u003e {2}","elisa.pdp.hero.target.information":"Target information","antibody.searchresults.row.figures":"figures","antibody.pdp.panelBuilder.videoDescription":"Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.","bid.common.tooltip.new.price.info":"\u003cstrong\u003ePrice:\u003c/strong\u003e Manufacturer suggested price \u003cbr\u003e \u003cstrong\u003eOnline price:\u003c/strong\u003e Web channel price","support.search.placeholder.tip.default":"by catalog number or product name","antibody.searchresults.rowheader.details":"Details","global.search.noResults.needHelp.technicalResources":"Technical Resources","antibody.pdp.productDetail.shippingcondition":"Shipping conditions","global.search.filter.persona.hitCount":"[{0}]","elisa.pdp.productdetails.speciestested":"Species (tested)","crispr.zero.results.reason.three":"The Assay ID you entered does not match the species you selected. Note that you do not need to select a species to search by Assay ID.","common.search.modal.search.heading.success":"Thank you for your feedback","global.search.filter.appliedFilters":"CURRENT FILTERS","antibody.pdp.reference.benchsci.disclaimer1":"By clicking the link above, you will be redirected to the Benchsci website. ","zrp.similar.results":"Search similar results in {0}","antibody.pdp.reference.benchsci.disclaimer2":"Disclaimer","antibody.serp.local.contactus":"Contact Us","antibody.searchresults.row.mostreferences":"Most References","support.search.placeholder.tip.productLiterature":"by catalog number or product name","supply.center.tooltip.info":"Products will be shipped from the nearest supply center.","antibody.searchresults.row.references":" References","serp.filtertext.displayname.clone":"Clone","antibody.searchresults.row.publishedfigures":" Published Figures","global.search.results.vectorCard.restrictions":"Restriction","global.search.results.msdsCard.catNo":"Catalog #","crispr.searchresults.rowheader.product":"Product","antibody.searchresults.rowheader.result":" result","global.search.noResults.querySuggestionWithNoResults":"Search for: \"\u003cstrike\u003e{0}\u003c/strike\u003e\" ({1} matches)","serp.filtertext.displayname.antigenspecies":"Antigen Species","antibody.pdp.reference.title":"Title ","global.search.results.geneCard.products":"Gene Based Products","oligos.jpOligos.bulkUpload.fileUploadDescription":"To upload multiple custom DNA oligo sequences, download the Sequence Template, enter the sequence information, and save as an .xls, .csv, or .txt file.","serp.nav.tabs.primary.antibodies":"Primary Antibodies","antibody.searchresults.row.without.keyword":"{0} {3}","antibody.serp.local.tfs":"This product is only available through your local Thermo Scientific supplier","oligos.jpOligos.bulkUpload.example":"Example","support.search.placeholder.tip.lull":"by catalog number or product name ","support.search.navigator.documentType.label.msds":"Material Safety Data Sheets","antibody.zero.results.reason":"Possible reasons that no {0} were found:","antibody.searchresults.row.not.orderable.online":"Not Orderable Online","antibody.serp.compare.add.to.cart":"Add to Cart","global.search.results.genomicsHelperCard.resultType.sirna":"siRNA","oligos.jpOligos.addProject.researcherNameMessage":"Only single-byte alphanumeric characters can be entered.","antibody.searchresults.row.with.keyword.results.header":"\u003cstrong\u003e{0} {3}\u003c/strong\u003e","antibody.searchresults.rowheader.target":"Target","antibody.pdp.productDetail.immunoelectrophoresis":"Immunoelectrophoresis","global.search.results.spectraCard.resultType":"Spectra Data","antibody.tfp.subheader.proteininformation":"Protein Information","global.search.results.brochureCard.documentType":"Product Literature","antibody.pdp.reference.subheading1":"Have you cited this product in a publication? ","antibody.pdp.commerceCard.yourprice":"Your Price","antibody.pdp.reference.subheading2":"Let us know","antibody.pdp.reference.subheading3":"so we can reference it in this datasheet.","crispr.zero.results.reason.one":"Spelling or typing errors. Use the product search above to modify your search.","global.search.results.minipdp.error.message":"This product cannot be ordered online or may be discontinued. For product status please contact \u003ca href\u003d\"http://template.lt.day.fqdn/content/lifetech/global/en/home/technical-resources/contact-us.html\"\u003eOrder Support\u003c/a\u003e.","antibody.pdp.commerceCard.onlineoffer":"Online Offer","antibody.searchresults.row.online.price.tooltip":"Online price is your best price.","support.search.noResults.executeQueryInSiteSearch":"Try this search against our \u003ca href\u003d\"{0}\"\u003eentire website results\u003c/a\u003e.","elisa.pdp.productdetails.geneid":"Gene ID","oligos.jpOligos.addOligo.reverseOligoName":"Reverse Oligo Name *","global.search.results.genomicsHelperCard.resultType.assay":"Assay","oligos.jpOligos.bulkUpload.uploadSelectFileDetails":"(.xls, .csv, or .txt format only; .csv or .txt only if using a procurement system)","oligos.jpOligos.addOligo.reverseComplementOligo":"Reverse Complement Oligo","antibody.serp.filter.target.species":"Target Species","antibody.pdp.reference.sortby":"Sort by","antibody.pdp.productDetail.invitroassay":"In vitro Assay","supply.center.button.text":"Supply Center","immunoassay.elisa.zero.results.reason":"Possible reasons that no {0} kits were found","global.search.results.cmgtProdCard.readMore":"View full product details \u0026gt;","antibody.sitemap.primary.description":"Extensively-validated primary antibodies for Western blot, IHC, ICC/IF, Flow Cytometry, Immunopreciption, ChIP, Functional assays, and other applications. Select a target to view all monoclonal and polyclonal antibodies.","serp.filtertext.displayname.lasercompatibility":"Laser Compatibility","global.search.results.manualCard.version":"Version","pdp.reference.text":"{0} Reference{1}","antibody.pdp.productDetail.gelshift":"Gel Shift","serp.filtertext.displayname.cellline":"Cell Line","antibody.pdp.productDetail.miscellaneouspubmed":"Miscellaneous PubMed ","oligos.jpOligos.messages.invalidOligos":"Please verify oligo parameters below","global.search.results.faqCard.resultType":"Product FAQ","serp.filtertext.displayname.targetclass":"Target Class","antibody.pdp.imageGallery.publishedFigures":"Published Figures","antibody.pdp.commerceCard.instock":"In stock","global.search.results.matches":"[{0} matches]","elisa.pdp.hero.about.this.kit.principleofmethod":"Principle of the method","support.search.placeholder.tip.manualsAndProtocols":"by catalog number or product name","antibody.pdp.hero.advancedVerification":"Advanced Verification","antibody.searchresults.rowheader.productGrade":"Product Grade","antibody.pdp.productDetail.gstpulldown":"GST Pull Down","global.search.results.vectorCard.polylinker":"Polylinker","antibody.pdp.productDetail.functionalassay":"Functional Assay","antibody.pdp.productDetail.immunohistochemistryfreefloating":"Immunohistochemistry - Free Floating","antibody.searchresults.rowheader.your.price":"Your Price ","global.search.listName.required":"Please enter a list name.","global.search.results.cmgtProdCard.quickProductInfo":"Quick Product Info","common.search.modal.search.label.email":"Email Address (Optional):","global.search.results.citationCard.authors":"Authors","support.search.techSupport.navigation.softwareDownloads":"Software Downloads","microbe.zero.results.header":"Your search for {0} returned {1} TaqMan® Microbe \u0026 ABR Detection Assays","elisa.pdp.productdetails.interassaycv":"Interassay CV","antibody.pdp.reference.more":"more","global.search.results.didyoumean":"Your search for \u003cb\u003e{0}\u003c/b\u003e returned no results. Showing results for \u003cb\u003e{1}\u003c/b\u003e.","antibody.pdp.productDetail.immunohistochemistry":"Immunohistochemistry ","elisa.pdp.productdetails.targetsubspecificity":"Target sub-specificity","global.search.results.assayCard.find":"Find {0} that match your search term \"{1}\"","global.search.noResults.resources.support":"View all Product Support Documents","oligos.jpOligos.bulkUpload.uploadSelectFile":"Please select your upload file","immunoassay.elisa.zero.results.browse.all":"Browse all ","elisa.pdp.productdesc.let.us.know":"Let us know so we can reference it here.","antibody.pdp.productDetail.seepublishedapplication":"View {0} publication{1}","antibody.pdp.productDetail.immunocytochemistry":"Immunocytochemistry","antibody.pdp.footer.performanceGuaranteeTitle":"Performance Guarantee","oligos.jpOligos.deleteOligo.message":"Are you sure you want to do this?","antibody.serp.compare.rrid":"RRID","crispr.searchresults.rowheader.compare":"Compare","tout.whatIsSharedList.titleTxt":"What is a shared list?","antibody.searchresults.rowheader.price":"Price ","antibody.serp.compare.species":"Species","antibody.searchresults.row.publishedfigure":" Published Figure","antibody.pdp.productDetail.recommendedHostIsotype":"Recommended Isotype Control","info.tout.header.sharedList":"Introducing shared lists","global.search.secondaryResults.navigators.orderingWebFaq.nav1":"Categories","antibody.pdp.productDetail.mobilepublishedapplication":"{0} publication{1}","oligos.jpOligos.bulkUpload.fileUploadDescriptionNote":"Note: Procurement system users must save as a .csv or .txt file.","antibody.pdp.productDetail.fluorescentquenching":"Fluorescent Quenching","serp.filtertext.displayname.tissuetype":"Tissue Type","oligos.jpOligos.basicEntry.subHeader1":"Order using the tool below or","oligos.jpOligos.basicEntry.subHeader2":"up to 200 oligo sequences at one time.","oligos.jpOligos.addOligo.primerName":"Oligo Name *","antibody.pdp.productDetail.proteinbiology":"Protein biology","antibody.searchresults.row.signin.user.tooltip":"Sign in","global.search.filter.topLevelFilters":"FILTER RESULTS BY","global.search.results.vectorCard.sequence":"Sequence","antibody.serp.filter.keepMyFilter":"Keep filters for Search","elisa.searchresults.rowheader.samplevolume":"Sample Volume","common.wsp.tooltip.supply.center.info":"Web orders only.","antibody.serp.compare.quantity":"Quantity","elisa.pdp.productdetails.targetsitespeificity":"Target site-specificity","global.search.results.cmgtProdCard.rfq":"request a quote","global.search.form.search.text.validation.message":"Please enter a search term","antibody.tfp.desc.viewless":"View less","serp.panel.builder.adText":"Building a flow cytometry panel?","common.search.modal.faq.button.submit":"submit","antibody.pdp.bioinformatics.functions":"Function(s)","antibody.pdp.bioinformatics.geneAliases":"Gene Aliases:","antibody.searchresults.sop.ends":"Ends","global.search.results.coaCard.resultType":"Certificate of Analysis","global.search.results.cmgtProdCard.unitSize":"Unit Size","global.search.noResults.noResultsFoundForQuery":"We did not find results for: \u003cstrong\u003e${query}\u003c/strong\u003e. ","global.search.results.coaCard.download":"Download","oligos.jpOligos.bulkUpload.field.purity":"Purification *","antibody.pdp.productDetail.peptideelisa":"peptide-ELISA","oligos.jpOligos.addOligo.reverseOligo":"Reverse Oligo","microbe.zero.results.contact.two":"QuantStudioFrontDesk@thermofisher.com","support.search.form.searcharea.dropdown.label":"in","antibody.pdp.hero.createCitation":"Create Citation","support.search.placeholder.tip.faq":"by catalog number, product name or keyword","support.search.form.query.input.label":"With these keywords","antibody.serp.compare.form":"Form","global.sharedList.noListTxt":"Create your first list","unified.card.mirna.dna":"Branched DNA miRNA assays","serp.filtertext.displayname.targetspecies":"Target Species","antibody.pdp.commerceCard.onlineprice":"Online Price","antibody.pdp.productDetail.publishedApplication":"Publications","antibody.pdp.productDetail.notapplicable":"Not applicable","antibody.searchresults.rowheader.species":"Species","unified.card.elisa":"ELISA kits","elisa.crossSellCard.assayDevelopment.specific.protein":"We provide assay development of your specific protein target.","antibody.serp.filter.clonality":"Clonality","antibody.serp.filter.conjugate":"Conjugate","global.search.results.vectorCard.catNo":"Cat. No.","antibody.pdp.commerceCard.longtermunavailablemsg":"This product is temporarily unavailable.","antibody.searchresults.row.from.invitrogen":"({2} {3} from Invitrogen)","global.search.form.search.button":"Search","antibody.pdp.imageGallery.view.product":"View Product","oligos.jpOligos.addOligo.purity":"Purification *","serp.filtertext.displayname.ptm":"PTM","antibody.searchresults.row.sop.special.offer":"Special offer","info.modal.header.createsharedListHeader":"Creating a shared list","antibody.tfp.subheader.synonyms":"Synonyms","antibody.searchresults.compare.add.product.to.compare":"+ Add a product to compare","antibody.pdp.productDetail.dilution":"Tested Dilution","antibody.serp.filter.cross.adsorbed":"Cross Adsorbed","microbe.zero.results.reason.one":"The product has been discontinued.","crispr.zero.results":"Zero Results.","elisa.pdp.hero.about.this.kit":"About This Kit","oligos.jpOligos.common.buttons.confirm":"Confirm","global.search.results.cmgtProdCard.ratings.notYetRatedLabel":"Rate this product","global.search.sortingOptions.dateSort.default":"Relevancy","common.search.modal.faq.validation.required.expectations":"Please select your expectation","antibody.searchresults.row.mobile.filters":"Filters","elisa.pdp.productdetails.shippingcondition":"Shipping conditions","antibody.pdp.reference.heading":"References","oligos.jpOligos.bulkUpload.header":"Custom DNA Oligos","global.search.results.lullCard.catNo":"Catalog #","elisa.pdp.hero.references":" References","common.search.modal.faq.label.expectations.met":"Met","elisa.pdp.productdetails.contents":"Contents","unified.card.pcr":"PCR and Sanger sequencing primers","antibody.serp.compare.published.species.reactivity":"Published Species Reactivity","antibody.pdp.relatedProductsHeader":"Related Products","antibody.pdp.productDetail.antibody":"Antibody","antibody.pdp.productDetail.knockout":"KnockOut","antibody.pdp.productDetail.viewspectra":"View spectra","antibody.pdp.footer.performanceGuaranteeText":"If an Invitrogen™ antibody doesn\u0027\u0027\u0027t perform as described on our website or datasheet,we\u0027\u0027\u0027ll replace the product at no cost to you, or provide you with a credit for a future purchase.*","antibody.searchresults.row.sop.online.purchase.only":"Online exclusive","antibody.pdp.commerceCard.discontinuedmsg":"This product has been discontinued","common.search.modal.search.label.contactMe":"May we contact you?","antibody.serp.filter.species":"Species","antibody.serp.compare.product.information":"Product Information","antibody.pdp.productDetail.excitationemissionprofile":"Excitation/Emission Max","global.search.results.minipdp.msds.heading":"MSDS","antibody.serp.filter.more.filters":"More","antibody.pdp.productDetail.immunoblot":"Immunoblot","serp.flt.srch.nomatchfound":"No match found","serp.panel.builder.adText.tryPBcn":" ","global.search.results.citationCard.journal":"Journal","control.sitemap.description":"Isotype control antibodies to help differentiate signal from background. Wide selection of negative controls for Flow Cytometry, IHC, Immunopreciptation, ChIP and other applications. Select a target class to view all formats.","antibody.pdp.productDetail.productDetails":"Product Details","elisa.pdp.productdetails.assayrange":"Assay range","info.modal.header.exportsharedListHeader":"Export as a spreadsheet","oligos.jpOligos.addOligo.complementOligoName":"Complement Oligo Name*","elisa.pdp.product.specifications":"Product Specifications","antibody.serp.compare.purification":"Purification","support.search.techSupport.navigation.heading":"Technical Resources","global.search.results.minipdp.vectors.heading":"Vector Maps","antibody.pdp.productDetail.celltreatment":"Cell Treatment","antibody.pdp.commerceCard.notorderableonline":"Not orderable online","oligos.jpOligos.bulkUpload.templateDownloadDescription":"Upload your saved sequence file here (.xls, .csv, or .txt format only; .csv or .txt only if using a procurement system).","elisa.pdp.productdetails.handsontime":"Hands-on time","elisa.pdp.productdetails.storage":"Storage","global.search.results.coaCard.lotNo":"Lot #","global.search.secondaryResults.navigators.citations.nav1":"Citation Journal","serp.nav.tabs.secondary.antibodies":"Secondary Antibodies","elisa.pdp.productdetails.proteinname":"Protein name","antibody.zero.results.reason.two":"The {0} is listed under an alternate gene/protein name. Try searching for synonyms.","global.search.sortingOptions.dateSort.label":"Sort By","elisa.searchresults.rowheader.assayrange":"Assay Range","info.modal.header.sharedList":"About shared lists","serp.filtertext.displayname.kitformat":"Kit Format","global.search.results.genomicsHelperCard.assayId":"Assay ID","oligos.jpOligos.addOligo.sequence":"Oligo Sequence (5\u0027 to 3\u0027) *","antibody.pdp.productDetail.type":"Type","antibody.zero.results.other.subtype":"Zero results for \"{0}\" but we found \u003ca href\u003d\"{1}query/{0}\"\u003e{2} {3}\u003c/a\u003e that match your search.","elisa.pdp.productdetails.instrument":"Instrument","serp.filtertext.displayname.brand":"Brand","antibody.serp.footer.custom.service":"Custom Antibody Service","elisa.pdp.hero.viewOther":"View all ({0}) {1} ELISA Kits","antibody.pdp.bioinformatics.molecularFunctions":"Molecular Function:","crispr.zero.results.reason.five":"The designated gene has no predesigned guide RNAs. Contact","common.search.modal.faq.heading":"Provide Feedback on this Answer"}; $m.magellanConfig = {"PlatesEnabled":"yes","newUserDataAPI":"https://tfcommerce-api-eks.cloud.thermofisher.net/api/store/v1/users/details","redisReplica":"magellan-redis-prod-us-east-1-ro.8k5m7q.ng.0001.use1.cache.amazonaws.com:6379","uglifyElisaSerp":"true","displayAssaySelectionVideo":"true","promoCodeEnabled":"true","sharedListUserName":"mguser","requeryOnZeroResults":"true","mediaGalleryServerSideRender":"true","oligoBaseURL":"/order/custom-oligo","saveItemToListURL":"/shared-list/addItemToList/","relatedProductsWidgetV2":"true","useMagellanPricingAPI":"true","ComergentBasePathAdirect":"/order/catalog/en/US/adirect/lt?cmd\u003d","pathwaysQueryPath":"/order/genome-database/pathwaysQuery?keyword\u003d","targetDetailsFromMetadataHandlerEnabled":"true","biozRestEndpoint":"https://back-gene-8.bioz.com/get_widget_data_multi/","regionalizedHostForCom":"www.thermofisher.com","useNewRedisCluster":"false","UserTrackingEnabled":"false","enableFishersciPriceUrl":"true","domain":"LT","citeAbUrl":"https://widget.citeab.com/citations?key\u003d15f4e791-1de2-4fad-b413-70c8829ee4c2\u0026code\u003d","promotionAvailabilityAPI":"/api/store/coupons/eligiblePromos","saveItemToListUrlNew":"/shared-list/addItemToList","removeUserBasedCookies":"false","enableBioz":"true","newSearchFormFiltersEnabled":"true","availabilityApiNotEnabledCountries":"US;CA","mapDataServer":"/api/magellan/alignmap/map-server","tfpDescriptionPreviewWordSize":"100","applicationsBySortOrderEnabled":"true","secAntibodyAdditionalFormat":"ON","useAlternateObjectCache":"ON","configurationSource":"YAML","uglifyCommonSerp":"true","magWebSvcsBase":"http://magellan-data.prod.magellanprod.thermofisher.net/MagWebSvcs","webCacheStatus":"ON","queryWithQuotes":"false","pearExpVerAllocations":"12","aspireAntibodyLink":"/us/en/home/products-and-services/aspire-member-program.html?cid\u003dbid_asp_sbu_r02_co_cp1438_pjt7721_col015466_0wm_tfs_df_awa_at_s00_PCAAntibodyPDP2021","environmentConfig":"FrontEndAppServers,fastInstance,solrBaseUrl,genDBIdentifier,magWebSvcsBase,webMethodsBase,aimsSvcsBase,ComergentHost,assayValidationBase,assayDetailsServiceURL","ninetyNineImageCapEnabled":"true","maxSpellCheckOptionsToFetch":"5","clientId":"app-magellan-search","newFilterEnabledProductSubTypes":"ANTIBODY_PRIMARY,ANTIBODY_SECONDARY,ANTIBODY_CONTROL","resultCountForProductSubTypesForMobileAndTFP":"antibody_primary:10","uglifyLegacyScripts":"true","MirnaSiteSearchLinkEnabled":"true","uglifyCompare":"true","geneOntologyPageSize":"40","addExtraCookieEnabled":"false","promotionalAdAPI":"/product/v1/promopod/","imagesS3Enabled":"true","newLogInpath":"/auth/login","newUserDetailsAPI":"/api/store/customer/users/v1/","enableElisaQuoteForKeywordSearch":"true","solrBaseUrl":"https://magellan-solr-prod-blue-solrcloud.magellanprod.thermofisher.net/solr","antibodyFamilyRedirects":"OFF","resultCount":"25","imageSearchEnabled":"true","microbeAssayUrl":"/microbe-detection/taqman/query/","awsFileNameForRedirectUrlRegEx":"Url_Redirect_RegEx.json","jsUnifier":"ON","galleryFilterEnabled":"true","mixedFamilyBrandSearch":"true","crisprSERPURL":"/crispr/invitrogen/query/","showUnreleased":"OFF","isProductionEnvironment":"true","scrollUpMinRowTablet":"1","useOptimizedResources":"ANTIBODY;IMMUNOASSAY;sirna;ge-quantigene;microrna;ceprimer;GE;GT;CNV;MIRNA;DPCR;CRISPRSRE","pdpHijackDisabledProducts":"CRISPR,MICROBE","CrossSellConjugateRule":"*Common_Applications \u003c Conjugate \u003c TradeName ^ Conjugate \u003c TradeName + Conjugate \u003c SKU","spellCheckEnabled":"true","magellanPathwaysBaseURL":"https://magellan.tfcom-eks-na-magellanprod.magellanprod.thermofisher.net/order/magellan-pathways","default-genePartURL":"/gene","ComergentUserInfoAPI":"/api/store/user-type/","antigenCacheControlTimestamp":"20220613","pathwaysImagemapPath":"/rest/PathwayDetailService/imagemap/","inventoryLocationCountryLists":"UK-AT-BE-BG-HR-CZ-DK-EE-FI-FR-DE-GB-GR-HU-IS-IE-IL-IT-LT-LU-MT-NL-NO-PL-PT-RO-SK-ES-SE-CH-TR","brightCovePanelBuilderVideoId":"6206990159001","ApplicationHost":"www.thermofisher.com","pantherPageSize":"40","techSupportEnabledCountries":"us;ca","availableReplicatesMCRB":"1,2,3,4,5,6","ComergentBasePath":"/order/catalog/en/US/direct/lt?cmd\u003d","aimsSvcsBase":"http://f1opd.corp.life:8080/aims-rest-service","spellCheckDisplayCount":"3","newPricingApi":"/api/magellan/pricing/","microbeEnabled":"true","awsRegion":"us-east-1","pricingAPICallGroupDelay":"200","custom_id_api_host":"/order/custom-genomic-products","DBSNPUrl":"//www.ncbi.nlm.nih.gov/projects/SNP","createOrRetrieveCartService":"https://tfcommerce-api-eks.cloud.thermofisher.net/api/store/carts/tp/retrieveCart?cartName\u003d","crsprTrueguideEnabled":"YES","unifiedAntibodySearchEnabled":"false","enableNewHeaderFooterForFisherSciForEU":"true","fisherSciStaticHost":"beta-static.fishersci.com","pricingWebWorkerEnabled":"true","useLegacyJsLibraries":"true","default-productPartURL":"/details","emailNotificationList":"marty.sherrill@lifetech.com","uglifyAntibodySerp":"true","aimsDescriptionServiceURL":"http://f1opd.corp.life:8080/aims-rest-service/descriptionForName","scrollUpMinRowMobile":"1","ComergentBasePathEntMgr":"/order/catalog/en/US/enterpriseMgr/lt?cmd\u003d","ApplicationHost-FISHERSCI_US":"www.fishersci.com","SolrEnabledProducts":"IMMUNO_ASSAY, ANTIBODY_TF, CRISPR_TF, MICROBE_TF, GENOTYPING","newAvailabilityApiEnabledCountries":"CN;KR;UK;AT;BE;BG;CM;HR;CZ;DK;EG;EE;FI;FR;GE;DE;GB;GR;HU;IS;IE;IL;JO;KZ;KE;LV;IT;LT;LU;MT;NL;NO;PL;PT;QA;RE;RO;RU;RS;SK;SI;ZA;ES;SE;CH;TN;TR;UA;AE","newPricingApiEnabledProducts":"ANTIBODY;IMMUNOASSAY","MyAvailabilityAPI":"/order/catalog/en/US/partnerMkt/lt?cmd\u003dvalidateAuthentication\u0026targetMessageType\u003dcommercePodOperations\u0026operation\u003dAvailability","HotJarID":"4539","coreRedisCacheTTLs":"productPDPHijackURL:604800,RelatedArraysCountCache:86400,KeywordGeneDataCache:86400,packageDataCache:90000,myPriceDataCache:43200,familyPageDetailsCache:86400,elisaFamilyPageDetailsCache:86400,antigenCountOnTFP:604800,catalogItemCache:86400,redirectProducts:-1,globalSearchResultsCache:86400","keepMyFiltersEnabled":"true","elisaSolrReQueryDisabled":"false","DomainName":"thermofisher.com","awsFolderNameForRedirectUrl":"productlist/","enableAdobeLaunch":"true","genePageSize":"100","secondaryConjugateOrder":"Functional Grade,Unconjugated,Biotin,AP,FITC,DyLight,Alexa Fluor,HRP,All Conjugates","pricingCacheMaxAge":"43200","techSupportModalEnabled":"true","isNewUserDataAPIEnabled":"false","dayServerBaseURL":"www.thermofisher.com","FASTSearchViewCache":"ON","brightcoveAccountId":"3663210762001","newAvailabilityAPI":"/api/store/sku/availability/","targetPageVideoEnabled":"true","chatEnabled":"false","catalogSearchEnabled":"true","ApplicationHost-fishersci":"www.fishersci.com","Authorization":"Bearer eyJ0eXAiOiJKV1QiLCJhbGciOiJIUzI1NiJ9.eyJpc3MiOiJ3d3cudGhlcm1vZmlzaGVyLmNvbSIsImlhdCI6OTQ2Njg0ODAwLCJleHAiOjQwNzA5MDg4MDAsImF1ZCI6Ind3dy50aGVybW9maXNoZXIuY29tIiwic3ViIjoibWFnZWxsYW4ifQ.cHEqJM4Z9C8r_p4q8bJBAcj2SKdjqITlGkhHor9_Eig","headerFooterStyle":"DYNAMIC","awsBucketNameForRedirectUrl":"magellan-url-redirects-prod","microbeGlobalDyeSizeEnable":"false","jpPearUXVerAllocations":"2","relatedProductsEnabledProductSubTypes":"ANTIBODY_PRIMARY, ANTIBODY_SECONDARY, ANTIBODY_CONTROL","newAvailabilityAPIWithOAuth2":"/api/store/product/availability/v1/","advVerificationTag":"true","catalogAPI":"/api/store/product/catalog/v1/","fastInstance":"uspgh-tfmfa2-p2.amer.thermo.com:15100,uspgh-tfmfa2-p3.amer.thermo.com:15100,uspgh-tfmfa2-p4.amer.thermo.com:15100","resultCountForProductSubTypes":"antibody_primary:25,antibody_secondary:25,antibody_control:50,antibody_protein:50,elisa:50","allowShowMoreShowLess":"false","ComergentHost":"www.thermofisher.com","crsprEnabled":"YES","hideStackTracesInLogs":"false","catalogClientSecretKey":"magellan/prod/catalog-client-secret","tfpDescriptionPreviewConfig":"sm:66,700;md:110,500;lg:132,900","magellanPricingAPIPath":"/api/magellan/pricing/","customSearchAPI":"/api/magellan/product/customSearch","fishersci-priceUrl":"https://www.fishersci.com/shop/service/price","maxSKUsInPricingCall":"20","pearUXVerAllocations":"2","metadataHandlerEnabledProductSubTypes":"ANTIBODY_PRIMARY,ANTIBODY_SECONDARY,ELISA,ANTIBODY_PROTEIN","imageSearchEnabledSubTypes":"ANTIBODY_PRIMARY,ANTIBODY_SECONDARY","addToCartService":"http://tfcom-api.cloud.thermofisher.net/api/store/third-party-addtocart/add","elcanoNewToolEnabledProducts":"ge:ST,ge:PT,genotyping:ST,cnv:ST","useGlobalStyles":"ON","AntibodiesEuropeanCountryList":"UK-AT-BE-BG-CM-HR-CZ-DK-EG-EE-FI-FR-GE-DE-GB-GR-HU-IS-IE-IL-JO-KZ-KE-LV-IT-LT-LU-MT-NL-NO-PL-PT-QA-RE-RO-RU-RS-SK-SI-ZA-ES-SE-CH-TN-TR-UA-AE","bulkQuoteCustomFormPricingApiPath":"/fields/specifications,antibodyCustomForms","techSupportExtUrlForConjugatedPAB":"true","briefXmlFlag":"false","genomicProductSearchQueryPath":"/order/genome-database/genomicProductsQuery?keyword\u003d","siteSearchQueryPath":"/search/service/results?query\u003d","elisaPageSize":"80","pricingApiTimeout":"10000","primaryConjugateOrder":"Agarose,Functional Grade,Unconjugated,All Conjugates","newCatalogAPI":"https://tfpc-catalog.qa1.cloudqa.thermofisher.net/api/store/sku?catalogNumbers\u003d","multiplexEnabled":"NO","citeAbEnabled":"true","referenceCount":"true","crossContextHeaderFooter":"OFF","flexiblePanelAssayTypes":"sirius,tlda,tap1,tap2,beamr,tesli,teslc","newTFPProteinUrlEnabled":"true","promoAdEnabledSubTypes":"ANTIBODY_PRIMARY,ANTIBODY_SECONDARY,ANTIBODY_CONTROL,ANTIBODY_PROTEIN,ELISA","pricingCallTimeoutSeconds":"10","enableBadges":"false","ComergentCookiePath":"/order","siteSearchProductApiTimeout":"5000","scrollUpMinRow":"1","debugProductSiteRegion":"false","epitopesModalImageMultiSizeEnabled":"true","antigenSearchEnabledSubTypes":"ANTIBODY_PRIMARY","regionalizedHostForCn":"www.thermofisher.cn","uglifyCoreScript":"true","useResponsiveOptIn":"false","enableProductSiteLogger":"false","newAvailabilityAPIWithOAuth2Enabled":"true","pearCookiesReductionEnabled":"true","browserCacheControl":"OFF","newGshEnabled":"true","filtersUrlEnabledProducts":"antibody;crispr;immunoassay;microbe","pearUXCookieName":"pearUXVerMar","panelBuilderMagWebApi":"http://magellan-data.prod.magellanprod.thermofisher.net/MagWebSvcs/PanelBuilder.jsp","EHCache_memory_setting":"ehcache-aws-prod","orderedApplications":"WB,IHC,IHC (P),IHC (PFA),IHC (F),IHC (Free),ICC/IF,ICC,IF,Flow,ELISA,IP,ChIP,ChIP-seq,Neu,FN,LUM,RIA,Ctrl,PLA,ARRAY,DB,IM,IA,GS,pep-ELISA,IDF,RIP,BLOCK,IE,TCA,LF,AGG,ISH,CT,HA,AP,IV,FQ,CA,IRMA,WB-Ag,GPD,FRET,MISC","HeaderFooterMicroServiceHost":"tfpt-header-footer.tfcom-eks-na-comerce-gateway-prd.commerceprod.thermofisher.net","fishersci-newpriceUrlEU":"api.fishersci.eu/fishersci-pricing/priceandavail","referenceSortByFilterRemoved":"true","compareAnalyticsEnabled":"true","enableNjord":"false","JapanPVNOEnabledForOnlinePrice":"true","qandaEnabledProductSubTypes":"ANTIBODY_PRIMARY, ANTIBODY_SECONDARY, ANTIBODY_CONTROL","fullSizeImageEnabled":"true","oldFischerSciPricingUrl":"shop/service/price","pathwaysApplicationBase":"https://magellan.tfcom-eks-na-magellanprod.magellanprod.thermofisher.net","enableShippingCondition":"true","filterSearchEnabled":"true","useMinifiedAssets":"false","adminEmail":"magellan.life@gmail.com","enablePdltMessage":"false","qnaWidgetAPI":"/api/magellan/qanda-ui/qna/widget/","hideTooltipForNewAvailabilityCountries":"CN","usePreloadedJS":"true","elcanoNewToolEnabled":"true","AssayDetailsServiceWarningThreshold":"3000","assayValidationBase":"http://f1opd.corp.life:8080/AssayValidation","ThirdPartySolrEnabledProducts":"ANTIBODY_TF","enableArrayConfiguratorCVIT":"true","thermoNonDotComEnabledCountries":"cn","magellanSearchFilter":"true","biozURL":"//nlpsearch-ptenlab-gene-8.appspot.com","tppEndCapEnabled":"false","techSupportModalEnabledSubTypes":"ANTIBODY_PRIMARY;ANTIBODY_SECONDARY;ANTIBODY_CONTROL","getAntigenCountInBackend":"true","newLogOutpath":"/auth/logout","hostName":"magellan-search-blue-5c9c5c4749-vpmkj","enableProductTabsForMicrobe":"true","uglifyVendorScripts":"true","eksCluster":"magellan.tfcom-eks-na-magellanprod.magellanprod.thermofisher.net","allowCommergentHostOverrides":"false","assaysEuropeanCountryList":"N/A","newTypeAheadEnabledProductSubTypes":"ANTIBODY_PRIMARY,ELISA","usePatternLibrary":"OFF","CmgtAddToCartService":"IVGNThirdPartyAddToCart","useRedis":"true","qnaLoaderThreshold":"#tf-related-products-container","errorLogDBInstance":"orcl_pri_gart","updateRegionalizedCanonicalUrlHost":"true","brightcoveApiSecretName":"magellan/prod/bcovpolicykey","SpeciesSortRelevancy":"ON","baseCatalogApi":"tfcommerce-api-eks-prod.commerceprod.thermofisher.net","ge-productPartURL":"/taqman-gene-expression/product","antigenSearchEnabled":"true","relatedProductsModuleURL":"/api/magellan/related-products-ui/widget/","techSupportExtUrl":"/home/technical-resources/contact-us/ext-antibody-technical-support","enablePrimaryEpitopeSrch":"true","assayIdsCount":"10","newTypeAheadEnabled":"true","redisCacheTTLs":"productPDPHijackURL:604800,RelatedArraysCountCache:86400,KeywordGeneDataCache:86400,packageDataCache:90000,myPriceDataCache:43200,familyPageDetailsCache:86400,elisaFamilyPageDetailsCache:86400,antigenCountOnTFP:604800,catalogItemCache:86400,redirectProducts:-1,globalSearchResultsCache:86400","ABPortalBaseURL":"(obsolete)","fastInstanceKey":"com.fastsearch.esp.search.http.qrservers","referenceFilterEnabled":"true","embeddedSearchFormDelay":"50","build-date":"2024-11-22T02:34:09Z","googleKey":"lW0Xt-iQmhGMfRn12R1YjbD1","KongGateway":"https://api.thermofisher.com","enableEstimatedAvailability":"true","qnaEnabledCountries":"CA,US","ComergentFilePath":"/order/catalog/en/US/css/ivgn/","biozHome":"https://www.bioz.com/tf_widget/","coreBuyerEmailAddress":"rashwor2@jhmi.edu,customorders@jhmi.edu,Manuel.Paniagua@thermofisher.com,Jose.Gutierrez@thermofisher.com,dave.kim@thermofisher.com","configurationInstance":"aws-prod-blue","newSourceIDToggle":"true","k8s-app-name":"magellan-search","CrossSellDbInstance":"orcl_pri_gart","solrSkuHijackEnabled":"true","enableOTMM":"true","sharedListURL":"/shared-list/getLists/","FisherSciEuropeanCountryList":"AT-BE-DK-FR-FI-DE-IE-IT-NL-NO-PT-ES-SE-CH-UK","medalliaEmbedJsToggle":"false","primaryPTMOrder":"Phosphorylated,Methylated,Acetylated,None","sequenceSearchServiceURL":"http://wmprd.thermofisher.com:5555/invoke/Life_GenomicsDesigns.process/receiveXML","newAvailabilityApiEnabled":"true","qnaModuleEnabled":"true","allConjugateEnabledProductSubTypes":"ANTIBODY_PRIMARY,ANTIBODY_SECONDARY,ANTIBODY_CONTROL","debugMode":"OFF","redirectToSiteSearchForMagellanZR":"false","sharedListsURL":"/us/en/home/technical-resources/ordering-web-faqs/shopping-cart-checkout/how-to-order/order.html#container-217a2","awsFileNameForRedirectUrl":"URL_Redirects.xlsx","productSearchCountAPI":"/api/magellan/product-service/getProductSearchCount?keyword\u003d","newGlobalSearchAPIEnabled":"true","HttpProtocol":"https://","elcanoNewToolBasePath":"/taqman","keywordTypeaheadBaseURL":"https://magellan.tfcom-eks-na-magellanprod.magellanprod.thermofisher.net/solr/lt-magellan-search-core/select","1000GenomesUrl":"//www.ncbi.nlm.nih.gov/variation/tools/1000genomes","jpPearExpVerAllocations":"1","enableNewHeaderFooter":"true","useFisherSciMfgPart":"false","MicrobeConfiguratorPath":"/microbe-detection/taqman/target-list/array-configurator-open","sharedListEligibleURL":"/order/catalog/msg/lt/rest/adirect/countries/SharedListEligible/","pathwaysReferencesPath":"/rest/PathwayDetailService/references/","pathwaysDescriptionPath":"/rest/PathwayDetailService/description/","benchSciImageLimit":"40","hideGeneDetailsProdTypes":"taqman,ge,plate,genotyping,cnv,microrna,dpcr,mutation,sirna,antibody","maxNoOfPublishedImages":"40","enableSOLRSearch":"true","redisMaster":"magellan-redis-prod-us-east-1.8k5m7q.ng.0001.use1.cache.amazonaws.com:6379","pubmedUrl":"http://pubmed.ncbi.nlm.nih.gov/pubmed/","loggingLevel":"DEBUG","pearExpSetupCookies":"NA","alternateSEOUrl":"EN-US;ZH-CN;EN-CN;x-default","bannerMessagesEnabled":"true","antibodyCacheControlTimestamp":"20240507","uglifyCommonPrimaryScripts":"true","ComergentProductPath":"/order/catalog/product/","isTfKongEnabled":"true","catalogAPIGatewayWithOauth2Enabled":"true","kongCreateCartService":"/api/store/carts/tp/retrieveCart","maxKeywordLength":"250","packageSource":"LT","enableJPSpecificStyle":"false","ProtectedBatchSearchMode":"OFF","newDocumentsApiExpanded":"true","newPricingApiDisabledCountries":";","ConfigurationSource":"YAML/aws-prod-blue/pgres_pri_gart_new","technicalSupportContactURL":"/global/en/home/technical-resources/contact-us.html","hostIp":"100.66.78.144","cacheStatus":"ON","userProfileService":"http://tfcom-api.cloud.thermofisher.net/api/store/v1/users/basicDetails","redirectUrlEnabled":"false","relatedProductsEnabled":"true","x-application":"magellan","chinaSupplyCenterEnabled":"true","proteinPageSize":"80","assayValidationApi":"http://f1opd.corp.life:8080/AssayValidation/processXml","videoInImageGalleryToggle":"true","HeaderFooterHost":"www.thermofisher.com","renderHeaderFooterViaSSI":"true","cacheControlTimestamp":"20240917","kongCartAddService":"/api/store/ordering/cart/v1","enableSop":"true","newDocumentsApiEnabled":"true","TargetRedirectEnabled":"true","keepMyFiltersEnabledSubTypes":"ANTIBODY_PRIMARY,ANTIBODY_SECONDARY,ANTIBODY_CONTROL,ANTIBODY_PROTEIN,ELISA","aspireElisaLink":"/us/en/home/products-and-services/aspire-member-program.html?cid\u003dbid_asp_sbu_r02_co_cp1438_pjt7721_col015466_0wm_tfs_df_awa_at_s00_PCAELISAPDP2021","citationLinks":"5","enableBulkQuoteCustomForm":"true","awsMetadataURL":"http://169.254.169.254/latest/meta-data/local-ipv4","webMethodsBase":"http://wmprd.thermofisher.com:5555","ge-genePartURL":"/taqman-gene-expression/gene","fischerSciPricingUrl":"fishersci-pricing/priceandavail","enableNewHeaderFooterForFisherSci":"true","allConjugateCountThreshold":"5","assayStatusServiceURL":"http://magellan-data.prod.magellanprod.thermofisher.net/MagWebSvcs/AssayStatus.jsp","magellanPricingAPILogs":"false","pdpProductSchemaEnabled":"true","regionalizedEnabledCountries":"CN","elisaTFPEnabled":"true","techSupportExtUrlForUnConjugatedPAB":"true","specialOfferPricingEnabledCountries":"US;CA;FI;ZA;DK;ES;NL;UK;OM;AT;CZ;HU;BG;FR;SI;SE;JO;LB;NO;CH;IE;PL;RO;BE;MK;MT;EG;GR;HR;SK;RS;AL;BA;BH;KW;KE;GB;DE;IT;IQ;QA;AE;SA;LY;ME;YE;CY;IL;PT;AD;AF;AI;AM;AO;AS;AW;AZ;BF;BI;BJ;BV;BW;BY;CC;CF;CG;CI;CM;CV;CX;DJ;DZ;EE;EH;ER;ET;FK;FO;FX;GA;GE;GF;GH;GL;GM;GN;GP;GQ;GS;GW;HM;IM;IO;IS;KG;KI;KM;KN;KZ;LC;LR;LS;LT;LU;LV;MA;MC;MD;MG;ML;MN;MQ;MR;MU;MW;MZ;NA;NC;NE;NF;NG;NR;NU;PF;PM;PN;PS;PW;RE;RU;RW;SB;SC;SH;SJ;SL;SM;SN;ST;SZ;TC;TD;TF;TG;TJ;TK;TM;TN;TR;TV;TZ;UA;UG;UZ;VA;VC;VG;VU;WF;YT;ZM;ZW","formatFilterEnabled":"true","useNewBrightCoveVideoPlayer":"true","genDBIdentifier":"orcl_pri_gen2","sharedListUserPwd":"mgprd@user","fisherSciSearchFormPageId":"IU5R4C73","chatBaseApiUrl":"https://chat-api.thermofisher.com","schemaMarkupEnabledForSERP":"true","newComparePanelEnable":"true","schemaMarkupEnabled":"true","spectraHost":"/order/fluorescence-spectraviewer","newChatGateWayEnabled":"false","searchXmlServiceURL":"http://magellan-data.prod.magellanprod.thermofisher.net/MagWebSvcs/AssayAnnotSearch.jsp","pearUXSetupCookies":"NA","IVGNaddToCartServiceURL":"/order/catalog/en/US/adirect/lt?cmd\u003dIVGNThirdPartyAddToCart","outboundEmailServer":"smtp.cloud.thermofisher.net","siteSearchProcessTimeout":"100","filterSearchExactFacetEnabled":"false","magellanClusterBaseURL":"https://magellan.tfcom-eks-na-magellanprod.magellanprod.thermofisher.net","pathwaysDetailsPath":"/rest/PathwayDetailService/detail/","translationEnabledProducts":"antibody;immunoassay","solrReQueryDisabled":"true","techSupportModalEmailFormUrl":"/home/technical-resources/contact-us/antibody-technical-support","geneDetailDataEnabled":"true","panelBuilderResultCount":"300","customToolBaseURL_sansProtocol":"/order/custom-genomic-products","redisSecret":"magellan/redis","lucidWorksAPIHostURL":"tfsearch-store-nginx-prod.srchcloudprod.thermofisher.net","newProteinUrlEnabled":"true","FrontEndAppServers":"http://magellan-srch-1-prod-blue.cloud.thermofisher.net:8080~~~http://magellan-srch-2-prod-blue.cloud.thermofisher.net:8080~~~http://magellan-srch-3-prod-blue.cloud.thermofisher.net:8080","userDataAPI":"http://tfam-users.prod.cloud.thermofisher.net/api/store/users/details","inventoryDataServiceUrl":"http://magellan-data.prod.magellanprod.thermofisher.net/MagWebSvcs/AssayInvLoc.jsp","pdltApplicableCountryList":"KR;CN","ApplicationBasePath":"/order/genome-database","spellCheckKeywords":"{\u0027keywords\u0027: [{\u0027antibody\u0027: \u0027anibody;anitbody;antabody;antbodie;antbody;anti-body;antibode;antibodi;antobody\u0027}]}","CommerceServiceYourPricePerSKUWarningThreshold":"5000","skuSummary":"/search/api/summary/sku/en/US/","assayDetailsServiceURL":"http://magellan-data.prod.magellanprod.thermofisher.net/MagWebSvcs/AssayAnnot.jsp","microbeBatchTermsLimit":"1000","mixedBrandSearch":"true","showUnentitled":"OFF","enableNewPricingTooltip":"true","sortSpellCheckCollations":"true","moveJqueryToBody":"true","blockPooledAssaysFormat":"TACMIRNA,SIRIUS,TLDA,TAP2,TAP1","packageServiceURL":"http://magellan-data.prod.magellanprod.thermofisher.net/MagWebSvcs/Package.jsp","crisprV2Enabled":"true","CommerceServiceListPricePerSKUWarningThreshold":"2000","fishersci-newpriceUrlUS":"api.fishersci.com/fishersci-pricing/priceandavail","categoryPageServiceURL":"http://magellan-data.prod.magellanprod.thermofisher.net/MagWebSvcs/GenomicListData.jsp","elisaImageGalleryToggle":"true","FisherSciEuropeanDomain":"www.fishersci"}; $m.countryCode = ""; // to point the header urls to local.thermofisher.com for local environment if ("aws-prod-blue".toLowerCase() === "local") { window.environmentURL.WCMSERVER = $m.magellanConfig['ApplicationHost']; } </script> </body> </html>