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Parghi</title> <meta name="description" content="Search results for: Anant Parghi"> <meta name="keywords" content="Anant Parghi"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="Anant Parghi" name="q" aria-label="Search"> <button class="btn btn-light my-2 my-sm-0" type="submit"><i class="fas fa-search"></i></button> </form> </div> <div class="collapse navbar-collapse mt-1" id="navbarMenu"> <ul class="navbar-nav ml-auto align-items-center" id="mainNavMenu"> <li class="nav-item"> <a class="nav-link" href="https://waset.org/conferences" title="Conferences in 2024/2025/2026">Conferences</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/disciplines" title="Disciplines">Disciplines</a> </li> <li 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Anant Parghi"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 16</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Anant Parghi</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">16</span> Application of Shape Memory Alloy as Shear Connector in Composite Bridges: Overview of State-of-the-Art</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Apurwa%20Rastogi">Apurwa Rastogi</a>, <a href="https://publications.waset.org/abstracts/search?q=Anant%20Parghi"> Anant Parghi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Shape memory alloys (SMAs) are memory metals with a high calibre to outperform as a civil construction material. They showcase novel functionality of undergoing large deformations and self-healing capability (pseudoelasticity) that leads to its emerging applications in a variety of areas. In the existing literature, most of the studies focused on the behaviour of SMA when used in critical regions of the smart buildings/bridges designed to withstand severe earthquakes without collapse and also its various applications in retrofitting works. However, despite having high ductility, their uses as construction joints and shear connectors in composite bridges are still unexplored in the research domain. This article presents to gain a broad outlook on whether SMAs can be partially used as shear connectors in composite bridges. In this regard, existing papers on the characteristics of shear connectors in the composite bridges will be discussed thoroughly and matched with the fundamental characteristics and properties of SMA. Since due to the high strength, stiffness, and ductility phenomena of SMAs, it is expected to be a good material for the shear connectors in composite bridges, and the collected evidence encourages the prior scrutiny of its partial use in the composite constructions. Based on the comprehensive review, important and necessary conclusions will be affirmed, and further emergence of research direction on the use of SMA will be discussed. This opens the window of new possibilities of using smart materials to enhance the performance of bridges even more in the near future. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=composite%20bridges" title="composite bridges">composite bridges</a>, <a href="https://publications.waset.org/abstracts/search?q=ductility" title=" ductility"> ductility</a>, <a href="https://publications.waset.org/abstracts/search?q=pseudoelasticity" title=" pseudoelasticity"> pseudoelasticity</a>, <a href="https://publications.waset.org/abstracts/search?q=shape%20memory%20alloy" title=" shape memory alloy"> shape memory alloy</a>, <a href="https://publications.waset.org/abstracts/search?q=shear%20connectors" title=" shear connectors"> shear connectors</a> </p> <a href="https://publications.waset.org/abstracts/139173/application-of-shape-memory-alloy-as-shear-connector-in-composite-bridges-overview-of-state-of-the-art" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/139173.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">190</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">15</span> Research Developments in Vibration Control of Structure Using Tuned Liquid Column Dampers: A State-of-the-Art Review</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jay%20Gohel">Jay Gohel</a>, <a href="https://publications.waset.org/abstracts/search?q=Anant%20Parghi"> Anant Parghi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A tuned liquid column damper (TLCD) is a modified passive system of tuned mass damper, where a liquid is used in place of mass in the structure. A TLCD consists of U-shaped tube with an orifice that produces damping against the liquid motion in the tube. This paper provides a state-of-the-art review on the vibration control of wind and earthquake excited structures using liquid dampers. Further, the paper will also discuss the theoretical background of TCLD, history of liquid dampers and existing literature on experimental, numerical, and analytical study. The review will also include different configuration of TLCD viz single TLCD, multi tuned liquid column damper (MTLCD), TLCD-Interior (TLCDI), tuned liquid column ball damper (TLCBD), tuned liquid column ball gas damper (TLCBGD), and pendulum liquid column damper (PLCD). The dynamic characteristics of the different configurate TLCD system and their effectiveness in reducing the vibration of structure will be discussed. The effectiveness of semi-active TLCD will be also discussed with reference to experimental and analytical results. In addition, the review will also provide the numerous examples of implemented TLCD to control the vibration in real structures. Based on the comprehensive review of literature, some important conclusions will be made and the need for future research will be identified for vibration control of structures using TLCD. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=earthquake" title="earthquake">earthquake</a>, <a href="https://publications.waset.org/abstracts/search?q=wind" title=" wind"> wind</a>, <a href="https://publications.waset.org/abstracts/search?q=tuned%20liquid%20column%20damper" title=" tuned liquid column damper"> tuned liquid column damper</a>, <a href="https://publications.waset.org/abstracts/search?q=passive%20response%20control" title=" passive response control"> passive response control</a>, <a href="https://publications.waset.org/abstracts/search?q=structures" title=" structures"> structures</a> </p> <a href="https://publications.waset.org/abstracts/139053/research-developments-in-vibration-control-of-structure-using-tuned-liquid-column-dampers-a-state-of-the-art-review" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/139053.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">208</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14</span> Gesture-Controlled Interface Using Computer Vision and Python</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vedant%20Vardhan%20Rathour">Vedant Vardhan Rathour</a>, <a href="https://publications.waset.org/abstracts/search?q=Anant%20Agrawal"> Anant Agrawal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The project aims to provide a touchless, intuitive interface for human-computer interaction, enabling users to control their computer using hand gestures and voice commands. The system leverages advanced computer vision techniques using the MediaPipe framework and OpenCV to detect and interpret real time hand gestures, transforming them into mouse actions such as clicking, dragging, and scrolling. Additionally, the integration of a voice assistant powered by the Speech Recognition library allows for seamless execution of tasks like web searches, location navigation and gesture control on the system through voice commands. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=gesture%20recognition" title="gesture recognition">gesture recognition</a>, <a href="https://publications.waset.org/abstracts/search?q=hand%20tracking" title=" hand tracking"> hand tracking</a>, <a href="https://publications.waset.org/abstracts/search?q=machine%20learning" title=" machine learning"> machine learning</a>, <a href="https://publications.waset.org/abstracts/search?q=convolutional%20neural%20networks" title=" convolutional neural networks"> convolutional neural networks</a> </p> <a href="https://publications.waset.org/abstracts/193844/gesture-controlled-interface-using-computer-vision-and-python" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/193844.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">12</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">13</span> Assessing Effectiveness of Manager-Subordinate Relationships at Workplace</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anant%20Sagar">Anant Sagar</a>, <a href="https://publications.waset.org/abstracts/search?q=Manisha%20Rana"> Manisha Rana</a>, <a href="https://publications.waset.org/abstracts/search?q=Surabhi%20Singhal"> Surabhi Singhal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study was aimed at analysing the effectiveness of manager-subordinate relationship and the different factors contributing to its effectiveness in a mid-sized IT organization. To define effectiveness in context of a manager-subordinate relationship, a model was framed which analyses personal and professional need fulfilment of subordinates. On basis of this need satisfaction based effectiveness model, relationships are categorized into four types anchored on two scales; Personal Need Satisfaction and Professional Need Satisfaction. These spatial effectiveness scores of a managerial relationship are further mapped with the relationship style of the manager to identify relationship styles which are associated with different effectiveness levels. The relationship style is analysed by using Impact Message Inventory-Circumplex (IMI-C). The results show that managerial relationship’s effectiveness is contingent on manager’s affiliation scores, subordinate’s previous work experience and the ability of managers to influence the personal and professional needs of employees through organizational policies. The findings reflect that effectiveness of manager-subordinate relationship increased in a friendly workplace where managers were adequately empowered to acknowledge employee needs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=relationship%20effectiveness" title="relationship effectiveness">relationship effectiveness</a>, <a href="https://publications.waset.org/abstracts/search?q=need%20fulfilment" title=" need fulfilment"> need fulfilment</a>, <a href="https://publications.waset.org/abstracts/search?q=managerial%20style" title=" managerial style"> managerial style</a>, <a href="https://publications.waset.org/abstracts/search?q=impact%20message%20inventory-circumplex" title=" impact message inventory-circumplex"> impact message inventory-circumplex</a> </p> <a href="https://publications.waset.org/abstracts/4397/assessing-effectiveness-of-manager-subordinate-relationships-at-workplace" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/4397.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">381</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">12</span> Synthesis and Thermoluminescence Study of Nanocrystalline Radiation Dosimeter CaSO₄:Ce/Sm/Dy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anant%20Pandey">Anant Pandey</a>, <a href="https://publications.waset.org/abstracts/search?q=Kanika%20Sharma"> Kanika Sharma</a>, <a href="https://publications.waset.org/abstracts/search?q=Vibha%20Chopra"> Vibha Chopra</a>, <a href="https://publications.waset.org/abstracts/search?q=Shaila%20Bahl"> Shaila Bahl</a>, <a href="https://publications.waset.org/abstracts/search?q=Pratik%20Kumar"> Pratik Kumar</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20P.%20Lochab"> S. P. Lochab</a>, <a href="https://publications.waset.org/abstracts/search?q=Birendra%20Singh"> Birendra Singh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper reports the thermoluminescence (TL) properties of nanocrystalline CaSO₄ activated by Ce, Sm, and Dy. TL properties are investigated by chiefly changing the dopant element and also by varying the concentration of the dopant elements (from 0.05 mol % to 0.5 mol %) so as to establish the optimized dopant concentration for each of the activators. The method of salt preparation used is the typical chemical co-precipitation method and the technique used for characterization of the prepared samples is the X-Ray Diffraction (XRD) technique. Further, the phosphors are irradiated with gamma radiation from Co-60 (1.25 MeV) source (dose range- 30 Gy to 500 Gy). The optimized concentration (vis-a-vis TL peak intensity) of activator for CaSO₄:Ce is found to be 0.2 mol %, for CaSO₄:Sm it is 0.1 mol % and for CaSO₄:Dy it is 0.2 mol %. Further, the primary study of the TL response curves for all the three phosphors confirms linearity in the studied dose range (i.e., 30 Gy to 500 Gy). Finally, CaSO₄:Dy was also studied for its energy dependence property which plays an important role in defining the utility of a phosphor for dosimetric applications. The range of doses used for the energy dependence study was from 30 Gy to 500 Gy from Cs-137 (0.662 MeV). The nano-phosphors showed potential to be used as radiation dosimeter in the studied range of gamma radiation and thus must be studied for a wider range of doses. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=gamma%20radiation" title="gamma radiation">gamma radiation</a>, <a href="https://publications.waset.org/abstracts/search?q=nanocrystalline" title=" nanocrystalline"> nanocrystalline</a>, <a href="https://publications.waset.org/abstracts/search?q=radiation%20dosimetry" title=" radiation dosimetry"> radiation dosimetry</a>, <a href="https://publications.waset.org/abstracts/search?q=thermoluminescence" title=" thermoluminescence"> thermoluminescence</a> </p> <a href="https://publications.waset.org/abstracts/89842/synthesis-and-thermoluminescence-study-of-nanocrystalline-radiation-dosimeter-caso4cesmdy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/89842.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">175</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> Securing Online Voting With Blockchain and Smart Contracts</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anant%20Mehrotra">Anant Mehrotra</a>, <a href="https://publications.waset.org/abstracts/search?q=Krish%20Phagwani"> Krish Phagwani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Democratic voting is vital for any country, but current methods like ballot papers or EVMs have drawbacks, including transparency issues, low voter turnout, and security concerns. Blockchain technology offers a potential solution by providing a secure, decentralized, and transparent platform for e-voting. With features like immutability, security, and anonymity, blockchain combined with smart contracts can enhance trust and prevent vote tampering. This paper explores an Ethereum-based e-voting application using Solidity, showcasing a web app that prevents duplicate voting through a token-based system, while also discussing the advantages and limitations of blockchain in digital voting. Voting is a crucial component of democratic decision-making, yet current methods, like paper ballots, remain outdated and inefficient. This paper reviews blockchain-based voting systems, highlighting strategies and guidelines to create a comprehensive electronic voting system that leverages cryptographic techniques, such as zero-knowledge proofs, to enhance privacy. It addresses limitations of existing e-voting solutions, including cost, identity management, and scalability, and provides key insights for organizations looking to design their own blockchain-based voting systems. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=electronic%20voting" title="electronic voting">electronic voting</a>, <a href="https://publications.waset.org/abstracts/search?q=smart%20contracts" title=" smart contracts"> smart contracts</a>, <a href="https://publications.waset.org/abstracts/search?q=blockchain%20nased%20voting" title=" blockchain nased voting"> blockchain nased voting</a>, <a href="https://publications.waset.org/abstracts/search?q=security" title=" security"> security</a> </p> <a href="https://publications.waset.org/abstracts/193842/securing-online-voting-with-blockchain-and-smart-contracts" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/193842.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">9</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> Evaluation of Promoter Hypermethylation in Tissue and Blood of Non-Small Cell Lung Cancer Patients and Association with Survival</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ashraf%20Ali">Ashraf Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Kriti%20Upadhyay"> Kriti Upadhyay</a>, <a href="https://publications.waset.org/abstracts/search?q=Puja%20Sohal"> Puja Sohal</a>, <a href="https://publications.waset.org/abstracts/search?q=Anant%20Mohan"> Anant Mohan</a>, <a href="https://publications.waset.org/abstracts/search?q=Randeep%20Guleria"> Randeep Guleria</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Gene silencing by aberrant promoter hypermethylation is common in lung cancer and is an initiating event in its development. Aim: To evaluate the gene promoter hypermethylation frequency in serum and tissue of lung cancer patients. Method: 95 newly diagnosed untreated advance stage lung cancer patients and 50 cancer free matched controls were studied. Bisulfite modification of tissue and serum DNA was done; modified DNA was used as a template for methylation-specific PCR analysis. Survival was assessed for one year. Results: Of 95 patients, 82% were non-small cell lung cancer (34% squamous cell carcinoma, 34% non-small cell lung cancer and 14% adenocarcinoma) and 18% were small cell lung cancer. Biopsy revealed that tissue of 89% and 75% of lung cancer patients and 85% and 52% of controls had promoter hypermethylated for MGMT (p=0.35) and p16(p<0.001) gene, respectively. In serum, 33% and 49% of lung cancer patients and 28% and 43% controls were positive for MGMT and p16 gene. No significant correlation was found between survival and clinico-pathological parameters. Conclusion: High gene promoter methylation frequency of p16 gene in tissue biopsy may be linked with early stages of carcinogenesis. Appropriate follow-up is required for confirmation of this finding. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=lung%20cancer" title="lung cancer">lung cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=MS-%20PCR" title=" MS- PCR"> MS- PCR</a>, <a href="https://publications.waset.org/abstracts/search?q=methylation" title=" methylation"> methylation</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20biology" title=" molecular biology"> molecular biology</a> </p> <a href="https://publications.waset.org/abstracts/96415/evaluation-of-promoter-hypermethylation-in-tissue-and-blood-of-non-small-cell-lung-cancer-patients-and-association-with-survival" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/96415.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">194</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> Framework to Quantify Customer Experience</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anant%20Sharma">Anant Sharma</a>, <a href="https://publications.waset.org/abstracts/search?q=Ashwin%20Rajan"> Ashwin Rajan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Customer experience is measured today based on defining a set of metrics and KPIs, setting up thresholds and defining triggers across those thresholds. While this is an effective way of measuring against a Key Performance Indicator ( referred to as KPI in the rest of the paper ), this approach cannot capture the various nuances that make up the overall customer experience. Customers consume a product or service at various levels, which is not reflected in metrics like Customer Satisfaction or Net Promoter Score, but also across other measurements like recurring revenue, frequency of service usage, e-learning and depth of usage. Here we explore an alternative method of measuring customer experience by flipping the traditional views. Rather than rolling customers up to a metric, we roll up metrics to hierarchies and then measure customer experience. This method allows any team to quantify customer experience across multiple touchpoints in a customer’s journey. We make use of various data sources which contain information for metrics like CXSAT, NPS, Renewals, and depths of service usage collected across a customer lifecycle. This data can be mined systematically to get linkages between different data points like geographies, business groups, products and time. Additional views can be generated by blending synthetic contexts into the data to show trends and top/bottom types of reports. We have created a framework that allows us to measure customer experience using the above logic. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=analytics" title="analytics">analytics</a>, <a href="https://publications.waset.org/abstracts/search?q=customers%20experience" title=" customers experience"> customers experience</a>, <a href="https://publications.waset.org/abstracts/search?q=BI" title=" BI"> BI</a>, <a href="https://publications.waset.org/abstracts/search?q=business%20operations" title=" business operations"> business operations</a>, <a href="https://publications.waset.org/abstracts/search?q=KPIs" title=" KPIs"> KPIs</a>, <a href="https://publications.waset.org/abstracts/search?q=metrics" title=" metrics"> metrics</a> </p> <a href="https://publications.waset.org/abstracts/152386/framework-to-quantify-customer-experience" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/152386.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">74</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Improving Human Resources Management in Indian Civil Service </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anant%20Deogaonkar">Anant Deogaonkar</a>, <a href="https://publications.waset.org/abstracts/search?q=Archana%20Nanoty"> Archana Nanoty</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The term civil service plays a vital role in functioning of any government. In today’s modern era of globalization civil services essentially contribute for the success of the good governance system. The civil service in India refers to the body of government officials employed in civil occupations that are neither political nor judicial. The Indian Civil Services were created to foster the idea of unity in diversity with the expectation of giving continuity and change in administration independent of the political scenario and turmoil affecting the country. The civil service is an integral part of administration and the structures of administration to determine the way civil service functions. The concept of good governance necessarily precludes the effective human resource management ensuring the root level reach of the good governance. The serious matter of concern is the element of change. The civil service in general has maintained status quo instead of sweeping changes in social and economic scenario. One may disagree for this but it is a fact on the street that the Indian civil service was not able to deliver up to the expectations of the people and was lacking on the service front. The effective management of human resources at civil service needs to be prioritized and will form a key factor in successful delivery of the desired results may be in minimum duration. This paper focuses on the various ways of effective management of human resources in civil services. It also highlights the importance of improvement in human resource management in civil services with the detailed discussion of positives and negatives if any of the human resource management in civil services. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=civil%20services" title="civil services">civil services</a>, <a href="https://publications.waset.org/abstracts/search?q=human%20resources%20management" title=" human resources management"> human resources management</a>, <a href="https://publications.waset.org/abstracts/search?q=India" title=" India"> India</a>, <a href="https://publications.waset.org/abstracts/search?q=governance" title=" governance "> governance </a> </p> <a href="https://publications.waset.org/abstracts/15103/improving-human-resources-management-in-indian-civil-service" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/15103.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">318</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Numerical Approach for Characterization of Flow Field in Pump Intake Using Two Phase Model: Detached Eddy Simulation </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rahul%20Paliwal">Rahul Paliwal</a>, <a href="https://publications.waset.org/abstracts/search?q=Gulshan%20Maheshwari"> Gulshan Maheshwari</a>, <a href="https://publications.waset.org/abstracts/search?q=Anant%20S.%20Jhaveri"> Anant S. Jhaveri</a>, <a href="https://publications.waset.org/abstracts/search?q=Channamallikarjun%20S.%20Mathpati"> Channamallikarjun S. Mathpati</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Large pumping facility is the necessary requirement of the cooling water systems for power plants, process and manufacturing facilities, flood control and water or waste water treatment plant. With a large capacity of few hundred to 50,000 m3/hr, cares must be taken to ensure the uniform flow to the pump to limit vibration, flow induced cavitation and performance problems due to formation of air entrained vortex and swirl flow. Successful prediction of these phenomena requires numerical method and turbulence model to characterize the dynamics of these flows. In the past years, single phase shear stress transport (SST) Reynolds averaged Navier Stokes Models (like k-ε, k-ω and RSM) were used to predict the behavior of flow. Literature study showed that two phase model will be more accurate over single phase model. In this paper, a 3D geometries simulated using detached eddy simulation (LES) is used to predict the behavior of the fluid and the results are compared with experimental results. Effect of different grid structure and boundary condition is also studied. It is observed that two phase flow model can more accurately predict the mean flow and turbulence statistics compared to the steady SST model. These validate model will be used for further analysis of vortex structure in lab scale model to generate their frequency-plot and intensity at different location in the set-up. This study will help in minimizing the ill effect of vortex on pump performance. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=grid%20structure" title="grid structure">grid structure</a>, <a href="https://publications.waset.org/abstracts/search?q=pump%20intake" title=" pump intake"> pump intake</a>, <a href="https://publications.waset.org/abstracts/search?q=simulation" title=" simulation"> simulation</a>, <a href="https://publications.waset.org/abstracts/search?q=vibration" title=" vibration"> vibration</a>, <a href="https://publications.waset.org/abstracts/search?q=vortex" title=" vortex"> vortex</a> </p> <a href="https://publications.waset.org/abstracts/85171/numerical-approach-for-characterization-of-flow-field-in-pump-intake-using-two-phase-model-detached-eddy-simulation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85171.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">175</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Evaluating the Impact of Landscape Values Associated With the Landscape Developemnt Approach of Neighbourhood Gardens; In Tier Two Cities of India; On Users’ Perception Towards the Space. Case: City of Nashik, Maharashtra, India</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anandi%20Anant%20Lale">Anandi Anant Lale</a>, <a href="https://publications.waset.org/abstracts/search?q=Pooja%20Sadananda%20Patil"> Pooja Sadananda Patil</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Neighbourhood gardens (NGs), in the rapidly growing tier two cities of India, play a pivotal role in maintaining and enhancing the quality of life of the dwellers in terms of mental, physical and socio- cultural well-being. They are the breathing areas which avail the opportunity of accessing nature while being in the close proximity of modern infrastructural provisions of the neighbourhood. In this article, the landscape values (viz. Cultural, Functional, Environmental and Perceptual) associated with the landscape development approach of neighbourhood gardens in the city of Nashik; one of the major tier two cities of Maharashtra; India, are studied through physical survey of selected NGs and the respective neighborhoods. Contextual study of the selected neighbourhood with the emphasis on dwellers' response in terms of physical as well as mental associations with the NGs is recorded through visitors' interviews. Analysis of interrelation of the landscape values and the users' response to the NGs revealed that each landscape value associated with the landscape development approach, has impact of diverse intensity on the users' perception, in different neighbourhoods. Contextual needs of selected neighbourhoods govern the user's perception towards the respective NGs and eventually define the role of landscape value/s associated with the landscape development approach of NG in deciding the competence of the space. The findings of the study can form the basis to redefine the landscape development approach for the future NGs in tier two cities of India that will justify the contextual needs of every neighbourhood through the emphasis of landscape values. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=neighbourhood%20garden" title="neighbourhood garden">neighbourhood garden</a>, <a href="https://publications.waset.org/abstracts/search?q=landscape%20value" title=" landscape value"> landscape value</a>, <a href="https://publications.waset.org/abstracts/search?q=user%E2%80%99s%20perception" title=" user’s perception"> user’s perception</a>, <a href="https://publications.waset.org/abstracts/search?q=context" title=" context"> context</a>, <a href="https://publications.waset.org/abstracts/search?q=landscape%20development" title=" landscape development"> landscape development</a> </p> <a href="https://publications.waset.org/abstracts/154049/evaluating-the-impact-of-landscape-values-associated-with-the-landscape-developemnt-approach-of-neighbourhood-gardens-in-tier-two-cities-of-india-on-users-perception-towards-the-space-case-city-of-nashik-maharashtra-india" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/154049.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">113</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Effect of Climate Change on Aridity Index in South Bihar</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Aayush%20Anant">Aayush Anant</a>, <a href="https://publications.waset.org/abstracts/search?q=Roshni%20Thendiyath"> Roshni Thendiyath</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aridity impacts on agriculture, as well as ecological, human health, and economic activities. In the present study, the effect of climate change on aridity index has been analysed in South Bihar for the past 30 year period by five types of aridity indices as Lang AI, De-Martonne AI, Erinc AI, Pinna combinative AI and UNEP AI. For the study of aridity index, the analysis of rainfall and temperature is significant. Rainfall was analysed for 30 year period from data of 23 gridded stations in for the period 1991-2020. The results show that rainfall pattern was decreasing with respect to previous decades for majority of stations. Trend of maximum, minimum and mean annual temperature has been observed, which shows increasing trend. Structural breakpoint was observed for mean annual temperature data series in year 2004. In period 1991-2004 mean annual temperature was 25.25 ºC, and in period 2005-2020, mean annual temperature was 25.7 ºC. Average aridity index has been calculated by all the above mentioned methods for whole 30 period. Lang AI shows that eastern part of study area is Humid type, and rest all is semi arid. De-Martonne AI also reveals that east part is humid, but rest of the study area is moist sub humid. According to Erinc AI and Pinna, combinative AI shows that whole south Bihar is dry sub humid and semi dry, respectively. UNEP AI shows most of the part as sub humid, and very small part in west is semi arid, while small part of east is humid. Temporal distribution of all the aridity indices shows a decreasing trend. This indicates a decrease in the humid areas in south Bihar for the selected time period. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drought" title="drought">drought</a>, <a href="https://publications.waset.org/abstracts/search?q=aridity%20index" title=" aridity index"> aridity index</a>, <a href="https://publications.waset.org/abstracts/search?q=climate%20change" title=" climate change"> climate change</a>, <a href="https://publications.waset.org/abstracts/search?q=rainfall" title=" rainfall"> rainfall</a>, <a href="https://publications.waset.org/abstracts/search?q=temperature" title=" temperature"> temperature</a> </p> <a href="https://publications.waset.org/abstracts/174900/effect-of-climate-change-on-aridity-index-in-south-bihar" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/174900.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">82</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Comparison of 18F-FDG and 11C-Methionine PET-CT for Assessment of Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Carcinoma</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sonia%20Mahajan%20Dinesh">Sonia Mahajan Dinesh</a>, <a href="https://publications.waset.org/abstracts/search?q=Anant%20Dinesh"> Anant Dinesh</a>, <a href="https://publications.waset.org/abstracts/search?q=Madhavi%20Tripathi"> Madhavi Tripathi</a>, <a href="https://publications.waset.org/abstracts/search?q=Vinod%20Kumar%20Ramteke"> Vinod Kumar Ramteke</a>, <a href="https://publications.waset.org/abstracts/search?q=Rajnish%20Sharma"> Rajnish Sharma</a>, <a href="https://publications.waset.org/abstracts/search?q=Anupam%20Mondal"> Anupam Mondal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Neo-adjuvant chemotherapy plays an important role in treatment of breast cancer by decreasing the tumour load and it offers an opportunity to evaluate response of primary tumour to chemotherapy. Standard anatomical imaging modalities are unable to accurately reflect the response to chemotherapy until several cycles of drug treatment have been completed. Metabolic imaging using tracers like 18F-fluorodeoxyglucose (FDG) as a marker of glucose metabolism or amino acid tracers like L-methyl-11C methionine (MET) have potential role for the measurement of treatment response. In this study, our objective was to compare these two PET tracers for assessment of response to neoadjuvant chemotherapy, in locally advanced breast carcinoma. Methods: In our prospective study, 20 female patients with histology proven locally advanced breast carcinoma underwent PET-CT imaging using FDG and MET before and after three cycles of neoadjuvant chemotherapy (CAF regimen). Thereafter, all patients were taken for MRM and the resected specimen was sent for histo-pathological analysis. Tumour response to the neoadjuvant chemotherapy was evaluated by PET-CT imaging using PERCIST criteria and correlated with histological results. Responses calculated were compared for statistical significance using paired t- test. Results: Mean SUVmax for primary lesion in FDG PET and MET PET was 15.88±11.12 and 5.01±2.14 respectively (p<0.001) and for axillary lymph nodes was 7.61±7.31 and 2.75±2.27 respectively (p=0.001). Statistically significant response in primary tumour and axilla was noted on both FDG and MET PET after three cycles of NAC. Complete response in primary tumour was seen in only 1 patient in FDG and 7 patients in MET PET (p=0.001) whereas there was no histological complete resolution of tumor in any patient. Response to therapy in axillary nodes noted on both PET scans were similar (p=0.45) and correlated well with histological findings. Conclusions: For the primary breast tumour, FDG PET has a higher sensitivity and accuracy than MET PET and for axilla both have comparable sensitivity and specificity. FDG PET shows higher target to background ratios so response is better predicted for primary breast tumour and axilla. Also, FDG-PET is widely available and has the advantage of a whole body evaluation in one study. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=11C-methionine" title="11C-methionine">11C-methionine</a>, <a href="https://publications.waset.org/abstracts/search?q=18F-FDG" title=" 18F-FDG"> 18F-FDG</a>, <a href="https://publications.waset.org/abstracts/search?q=breast%20carcinoma" title=" breast carcinoma"> breast carcinoma</a>, <a href="https://publications.waset.org/abstracts/search?q=neoadjuvant%20chemotherapy" title=" neoadjuvant chemotherapy"> neoadjuvant chemotherapy</a> </p> <a href="https://publications.waset.org/abstracts/1987/comparison-of-18f-fdg-and-11c-methionine-pet-ct-for-assessment-of-response-to-neoadjuvant-chemotherapy-in-locally-advanced-breast-carcinoma" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1987.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">510</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Evaluation of Mito-Uncoupler Induced Hyper Metabolic and Aggressive Phenotype in Glioma Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yogesh%20Rai">Yogesh Rai</a>, <a href="https://publications.waset.org/abstracts/search?q=Saurabh%20Singh"> Saurabh Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanjay%20Pandey"> Sanjay Pandey</a>, <a href="https://publications.waset.org/abstracts/search?q=Dhananjay%20K.%20Sah"> Dhananjay K. Sah</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20G.%20Roy"> B. G. Roy</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20S.%20Dwarakanath"> B. S. Dwarakanath</a>, <a href="https://publications.waset.org/abstracts/search?q=Anant%20N.%20Bhatt"> Anant N. Bhatt</a> </p> <p class="card-text"><strong>Abstract:</strong></p> One of the most common signatures of highly malignant gliomas is their capacity to metabolize more glucose to lactic acid than normal brain tissues, even under normoxic conditions (Warburg effect), indicating that aerobic glycolysis is constitutively upregulated through stable genetic or epigenetic changes. However, oxidative phosphorylation (OxPhos) is also required to maintain the mitochondrial membrane potential for tumor cell survival. In the process of tumorigenesis, tumor cells during fastest growth rate exhibit both high glycolytic and high OxPhos. Therefore, metabolically reprogrammed cancer cells with combination of both aerobic glycolysis and altered OxPhos develop a robust metabolic phenotype, which confers a selective growth advantage. In our study, we grew the high glycolytic BMG-1 (glioma) cells with continuous exposure of mitochondrial uncoupler 2, 4, dinitro phenol (DNP) for 10 passages to obtain a phenotype of high glycolysis with enhanced altered OxPhos. We found that OxPhos modified BMG (OPMBMG) cells has similar growth rate and cell cycle distribution but high mitochondrial mass and functional enzymatic activity than parental cells. In in-vitro studies, OPMBMG cells showed enhanced invasion, proliferation and migration properties. Moreover, it also showed enhanced angiogenesis in matrigel plug assay. Xenografted tumors from OPMBMG cells showed reduced latent period, faster growth rate and nearly five folds reduction in the tumor take in nude mice compared to BMG-1 cells, suggesting that robust metabolic phenotype facilitates tumor formation and growth. OPMBMG cells which were found radio-resistant, showed enhanced radio-sensitization by 2-DG as compared to the parental BMG-1 cells. This study suggests that metabolic reprogramming in cancer cells enhances the potential of migration, invasion and proliferation. It also strengthens the cancer cells to escape the death processes, conferring resistance to therapeutic modalities. Our data also suggest that combining metabolic inhibitors like 2-DG with conventional therapeutic modalities can sensitize such metabolically aggressive cancer cells more than the therapies alone. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=2-DG" title="2-DG">2-DG</a>, <a href="https://publications.waset.org/abstracts/search?q=BMG" title=" BMG"> BMG</a>, <a href="https://publications.waset.org/abstracts/search?q=DNP" title=" DNP"> DNP</a>, <a href="https://publications.waset.org/abstracts/search?q=OPM-BMG" title=" OPM-BMG"> OPM-BMG</a> </p> <a href="https://publications.waset.org/abstracts/61952/evaluation-of-mito-uncoupler-induced-hyper-metabolic-and-aggressive-phenotype-in-glioma-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/61952.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">226</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Reviving Customs: Examining the Vernacular Habitus in Modern Marathi Film via the Tamasha Genre</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amar%20Ramesh%20Wayal">Amar Ramesh Wayal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Marathi cinema, an integral part of India’s diverse film industry, has significantly evolved in its storytelling and aesthetics, with the Tamasha genre being central to this evolution. Tamasha, a traditional form of Marathi theatre, features vibrant dance and music, especially the rhythmic and often suggestive musical genre, lavani. It gained cinematic prominence in the 1960s with Anant Mane’s Sangtye Aika (1959), which brought and popularized Tamasha to the silver screen, and V. Shantaram’s Pinjra (1972), an iconic Tamasha drama. Despite early success, Tamasha films declined in popularity until Natarang (2010) revitalized interest in this traditional form. This study examines the relevance and evolution of the Tamasha genre in Marathi cinema through contemporary films like Ek Hota Vidushak by Jabbar Patel (1992), Natarang (2010) by Ravi Jadhav, and Tamasha Live (2022) by Sanjay Jadhav. The selection of the films is based on their significant roles in the evolution of the Tamasha in Marathi cinema. Ek Hota Vidushak explores socio-political themes through Tamasha, Natarang depicts the struggles and emotional depth of Tamasha performers, and Tamasha Live integrates traditional Tamasha into modern cinema. By analysing films from different periods, this study highlights the genre’s reinterpretation and adaptation over time. The study employs a qualitative approach, utilizing textual analysis and cultural critique to examine the portrayal and evolution of Tamasha in selected films. It aims to illuminate the complex relationship between tradition and modernity in Marathi cinema through Foucauldian discourse analysis and Pierre Bourdieu’s concept of “vernacular habitus,” which refers to local, indigenous cultural spaces that shape people’s perceptions and expressions. By analyzing these films, the study seeks to understand how traditional cultural forms are integrated into contemporary cinematic narratives. However, this method has limitations, such as subjectivity in interpretation and the need for extensive contextual knowledge. Qualitative research can be subject to researcher bias, affecting analysis and conclusions. To mitigate this, this study maintains rigorous reflexivity and transparency regarding the researcher’s positionality. Furthermore, findings from specific film analyses may not be universally applicable to all Tamasha films or broader Marathi cinema. To enhance the study’s robustness, future research could incorporate comparative or quantitative data to complement qualitative insights. Despite these challenges, qualitative research is crucial for exploring cultural artifacts and their significance within specific contexts. By triangulating qualitative findings with diverse perspectives and acknowledging limitations, this study aims to provide a nuanced understanding of how Tamasha cinema preserves and revitalizes Maharashtra’s folk traditions while adapting them to contemporary contexts. Analyzing films by Jabbar Patel, Ravi Jadhav, and Sanjay Jadhav shows how these filmmakers balance traditional aesthetics with modern storytelling, bridging historical continuity with contemporary relevance. This study offers insights into how indigenous traditions like Tamasha continue to shape and define cinematic narratives in Maharashtra. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Marathi%20cinema" title="Marathi cinema">Marathi cinema</a>, <a href="https://publications.waset.org/abstracts/search?q=Tamasha%20genre" title=" Tamasha genre"> Tamasha genre</a>, <a href="https://publications.waset.org/abstracts/search?q=vernacular%20habitus" title=" vernacular habitus"> vernacular habitus</a>, <a href="https://publications.waset.org/abstracts/search?q=discourse%20analysis" title=" discourse analysis"> discourse analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=cultural%20evolution" title=" cultural evolution"> cultural evolution</a> </p> <a href="https://publications.waset.org/abstracts/187576/reviving-customs-examining-the-vernacular-habitus-in-modern-marathi-film-via-the-tamasha-genre" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/187576.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">32</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Amifostine Analogue, Drde-30, Attenuates Radiation-Induced Lung Injury in Mice</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Aastha%20Arora">Aastha Arora</a>, <a href="https://publications.waset.org/abstracts/search?q=Vikas%20Bhuria"> Vikas Bhuria</a>, <a href="https://publications.waset.org/abstracts/search?q=Saurabh%20Singh"> Saurabh Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=Uma%20Pathak"> Uma Pathak</a>, <a href="https://publications.waset.org/abstracts/search?q=Shweta%20Mathur"> Shweta Mathur</a>, <a href="https://publications.waset.org/abstracts/search?q=Puja%20P.%20Hazari"> Puja P. Hazari</a>, <a href="https://publications.waset.org/abstracts/search?q=Rajat%20Sandhir"> Rajat Sandhir</a>, <a href="https://publications.waset.org/abstracts/search?q=Ravi%20Soni"> Ravi Soni</a>, <a href="https://publications.waset.org/abstracts/search?q=Anant%20N.%20Bhatt"> Anant N. Bhatt</a>, <a href="https://publications.waset.org/abstracts/search?q=Bilikere%20S.%20Dwarakanath"> Bilikere S. Dwarakanath</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Radiotherapy is an effective curative and palliative option for patients with thoracic malignancies. However, lung injury, comprising of pneumonitis and fibrosis, remains a significant clin¬ical complication of thoracic radiation, thus making it a dose-limiting factor. Also, injury to the lung is often reported as part of multi-organ failure in victims of accidental radiation exposures. Radiation induced inflammatory response in the lung, characterized by leukocyte infiltration and vascular changes, is an important contributing factor for the injury. Therefore, countermeasure agents to attenuate radiation induced inflammatory response are considered as an important approach to prevent chronic lung damage. Although Amifostine, the widely used, FDA approved radio-protector, has been found to reduce the radiation induced pneumonitis during radiation therapy of non-small cell lung carcinoma, its application during mass and field exposure is limited due to associated toxicity and ineffectiveness with the oral administration. The amifostine analogue (DRDE-30) overcomes this limitation as it is orally effective in reducing the mortality of whole body irradiated mice. The current study was undertaken to investigate the potential of DRDE-30 to ameliorate radiation induced lung damage. DRDE-30 was administered intra-peritoneally, 30 minutes prior to 13.5 Gy thoracic (60Co-gamma) radiation in C57BL/6 mice. Broncheo- alveolar lavage fluid (BALF) and lung tissues were harvested at 12 and 24 weeks post irradiation for studying inflammatory and fibrotic markers. Lactate dehydrogenase (LDH) leakage, leukocyte count and protein content in BALF were used as parameters to evaluate lung vascular permeability. Inflammatory cell signaling (p38 phosphorylation) and anti-oxidant status (MnSOD and Catalase level) was assessed by Western blot, while X-ray CT scan, H & E staining and trichrome staining were done to study the lung architecture and collagen deposition. Irradiation of the lung increased the total protein content, LDH leakage and total leukocyte count in the BALF, reflecting endothelial barrier dysfunction. These disruptive effects were significantly abolished by DRDE-30, which appear to be linked to the DRDE-30 mediated abrogation of activation of the redox-sensitive pro- inflammatory signaling cascade, the MAPK pathway. Concurrent administration of DRDE-30 with radiation inhibited radiation-induced oxidative stress by strengthening the anti-oxidant defense system and abrogated p38 mitogen-activated protein kinase activation, which was associated with reduced vascular leak and macrophage recruitment to the lungs. Histopathological examination (by H & E staining) of the lung showed radiation-induced inflammation of the lungs, characterized by cellular infiltration, interstitial oedema, alveolar wall thickening, perivascular fibrosis and obstruction of alveolar spaces, which were all reduced by pre-administration of DRDE-30. Structural analysis with X-ray CT indicated lung architecture (linked to the degree of opacity) comparable to un-irradiated mice that correlated well with the lung morphology and reduced collagen deposition. Reduction in the radiation-induced inflammation and fibrosis brought about by DRDE-30 resulted in a profound increase in animal survival (72 % in the combination vs 24% with radiation) observed at the end of 24 weeks following irradiation. These findings establish the potential of the Amifostine analogue, DRDE-30, in reducing radiation induced pulmonary injury by attenuating the inflammatory and fibrotic responses. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=amifostine" title="amifostine">amifostine</a>, <a href="https://publications.waset.org/abstracts/search?q=fibrosis" title=" fibrosis"> fibrosis</a>, <a href="https://publications.waset.org/abstracts/search?q=inflammation" title=" inflammation"> inflammation</a>, <a href="https://publications.waset.org/abstracts/search?q=lung%20injury%20radiation" title=" lung injury radiation"> lung injury radiation</a> </p> <a href="https://publications.waset.org/abstracts/40537/amifostine-analogue-drde-30-attenuates-radiation-induced-lung-injury-in-mice" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/40537.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">510</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); 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