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These publications provide an evidence-based overview of basic and clinical science topics and identify areas that require additional research."> <svg class="connect__social-icon" role="img" aria-label="print"> <title> print </title><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="/web/20210214102730im_/https://www.endocrine.org/assets/img/common/svg-sprite.svg#social-print"> </use> </svg> </a> </li> </ul> </section> <div class="rich-text end-page-header"> <h1>Scientific Statements</h1> <p class="subtitle"> an evidence-based comprehensive overview of select basic and clinical science topics</p> </div> <div class="rich-text"> <p>Scientific statements explore the scientific basis of disease, discuss how this knowledge can be applied in clinical practice, and identify areas that require additional research. Topics are selected on the basis of their emerging scientific impact on disease and their clinical relevance to the general population. Scientific Statements are developed by a Task Force of experts with review by committees of the Endocrine Society.</p> <h3>Current Scientific Statements</h3> <div class="end-more-text js-more-text"> </div> </div> <section class="child-page-list"> <ul class="child-page-list__list"> <li class="child-page-list__item"> <article> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/the-science-of-obesity-management" title="The Science of Obesity Management"> <div class="child-page-list__item-content"> <h3 class="child-page-list__item-title">The Science of Obesity Management</h3> <p class="child-page-list__item-description">The prevalence of obesity, measured by body mass index, has risen to unacceptable levels in both men and women in the United States and worldwide with resultant hazardous health implications. Genetic, environmental, and behavioral factors influence the development of obesity, and both the general public and health professionals stigmatize those who suffer from the disease. </p> </div> </a> </article> </li> <li class="child-page-list__item"> <article> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/diabetic-microvascular-disease" title="Diabetic Microvascular Disease"> <div class="child-page-list__item-content"> <h3 class="child-page-list__item-title">Diabetic Microvascular Disease</h3> <p class="child-page-list__item-description">Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs. Our understanding of the genesis of this injury and of potential interventions to prevent, limit, or reverse injury/dysfunction is continuously evolving.</p> </div> </a> </article> </li> <li class="child-page-list__item"> <article> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/obesity-pathogenesis" title="Obesity Pathogenesis"> <div class="child-page-list__item-content"> <h3 class="child-page-list__item-title">Obesity Pathogenesis</h3> <p class="child-page-list__item-description">Obesity is among the most common and costly chronic disorders worldwide. Estimates suggest that in the United States obesity affects one-third of adults, accounts for up to one-third of total mortality, is concentrated among lower income groups, and increasingly affects children as well as adults. </p> </div> </a> </article> </li> <li class="child-page-list__item"> <article> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/screening-for-endocrine-hypertension" title="Screening for Endocrine Hypertension"> <div class="child-page-list__item-content"> <h3 class="child-page-list__item-title">Screening for Endocrine Hypertension</h3> <p class="child-page-list__item-description">Hypertension may be the initial clinical presentation for at least 15 endocrine disorders. An accurate diagnosis of endocrine hypertension provides clinicians with the opportunity to render a surgical cure or to achieve an optimal clinical response with specific pharmacologic therapy.</p> </div> </a> </article> </li> <li class="child-page-list__item"> <article> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/adverse-health-consequences-of-performance-enhancing-drugs" title="Adverse Health Consequences of Performance-Enhancing Drugs"> <div class="child-page-list__item-content"> <h3 class="child-page-list__item-title">Adverse Health Consequences of Performance-Enhancing Drugs</h3> <p class="child-page-list__item-description">Despite the high prevalence of performance-enhancing drug (PED) use, media attention has focused almost entirely on PED use by elite athletes to illicitly gain a competitive advantage in sports, and not on the health risks of PEDs.</p> </div> </a> </article> </li> <li class="child-page-list__item"> <article> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/compounded-bioidentical-hormones-in-endocrinology-practice" title="Compounded Bioidentical Hormones in Endocrinology Practice"> <div class="child-page-list__item-content"> <h3 class="child-page-list__item-title">Compounded Bioidentical Hormones in Endocrinology Practice</h3> <p class="child-page-list__item-description">Custom-compounded bioidentical hormone therapy (HT) has become widely used in current endocrine practice, which has led to unnecessary risks with treatment.</p> </div> </a> </article> </li> <li class="child-page-list__item"> <article> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/edc2" title="Endocrine-Disrupting Chemicals 2"> <div class="child-page-list__item-content"> <h3 class="child-page-list__item-title">Endocrine-Disrupting Chemicals 2</h3> <p class="child-page-list__item-description">The Endocrine Society's first Scientific Statement in 2009 provided a wake-up call to the scientific community about how environmental endocrine-disrupting chemicals (EDCs) affect health and disease. Five years later, a substantially larger body of literature has solidified our understanding of plausible mechanisms underlying EDC actions and how exposures in animals and humans鈥攅specially during development鈥攎ay lay the foundations for disease later in life. </p> </div> </a> </article> </li> <li class="child-page-list__item"> <article> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/polycystic-ovary-syndrome" title="Polycystic Ovary Syndrome"> <div class="child-page-list__item-content"> <h3 class="child-page-list__item-title">Polycystic Ovary Syndrome</h3> <p class="child-page-list__item-description">Polycystic ovary syndrome (PCOS) is a heterogeneous and complex disorder that has both adverse reproductive and metabolic implications for affected women. However, there is generally poor understanding of its etiology.</p> </div> </a> </article> </li> <li class="child-page-list__item"> <article> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/health-disparities-in-endocrine-disorders" title="Health Disparities in Endocrine Disorders: Biological, Clinical, and Nonclinical Factors"> <div class="child-page-list__item-content"> <h3 class="child-page-list__item-title">Health Disparities in Endocrine Disorders: Biological, Clinical, and Nonclinical Factors</h3> <p class="child-page-list__item-description">Several themes emerged in the statement, including a need for basic science, population-based, translational and health services studies to explore underlying mechanisms contributing to endocrine health disparities.</p> </div> </a> </article> </li> <li class="child-page-list__item"> <article> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/nonskeletal-effects-of-vitamin-d" title="Nonskeletal Effects of Vitamin D: An Endocrine Society Scientific Statement"> <div class="child-page-list__item-content"> <h3 class="child-page-list__item-title">Nonskeletal Effects of Vitamin D: An Endocrine Society Scientific Statement</h3> <p class="child-page-list__item-description">Significant controversy has emerged over the last decade concerning the effects of vitamin D on skeletal and nonskeletal tissues. The demonstration that the vitamin D receptor is expressed in virtually all cells of the body and the growing body of observational data supporting a relationship of serum 25-hydroxyvitamin D to chronic metabolic, cardiovascular, and neoplastic diseases have led to widespread utilization of vitamin D supplementation for the prevention and treatment of numerous disorders.</p> </div> </a> </article> </li> <li class="child-page-list__item"> <article> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/postmenopausal-hormone-therapy" title="Postmenopausal Hormone Therapy"> <div class="child-page-list__item-content"> <h3 class="child-page-list__item-title">Postmenopausal Hormone Therapy</h3> <p class="child-page-list__item-description">Our objective was to provide a scholarly review of the published literature on menopausal hormonal therapy (MHT), make scientifically valid assessments of the available data, and grade the level of evidence available for each clinically important endpoint.</p> </div> </a> </article> </li> <li class="child-page-list__item"> <article> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/edc" title="Endocrine-Disrupting Chemicals"> <div class="child-page-list__item-content"> <h3 class="child-page-list__item-title">Endocrine-Disrupting Chemicals</h3> <p class="child-page-list__item-description">In this first Scientific Statement of The Endocrine Society, we present the evidence that endocrine disruptors have effects on male and female reproduction, breast development and cancer, prostate cancer, neuroendocrinology, thyroid, metabolism and obesity, and cardiovascular endocrinology. </p> </div> </a> </article> </li> </ul> </section> </div> </div> <div class="container__col"> <div class="container__inner"> <nav class="end-lp-secondary-nav js-secondary-nav" style="transform:translateY(52px);margin-bottom:52px;" aria-label="Site Sub navigation"> <a 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Obesity Management</a> </li> <li class="end-lp-secondary-nav__subitem "> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/diabetic-microvascular-disease" id="fd64043d-bbc8-4a20-9fc2-f25083461d29">Diabetic Microvascular Disease</a> </li> <li class="end-lp-secondary-nav__subitem "> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/obesity-pathogenesis" id="34b7396c-fedb-4c12-96f8-6f71389ecea9">Obesity Pathogenesis</a> </li> <li class="end-lp-secondary-nav__subitem "> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/screening-for-endocrine-hypertension" id="37c5f850-5ca8-4b6d-8c48-910528cff3e0">Screening for Endocrine Hypertension</a> </li> <li class="end-lp-secondary-nav__subitem "> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/adverse-health-consequences-of-performance-enhancing-drugs" id="5918b0a2-4fc6-42f9-b0be-d8bc1b0ad36a">Adverse Health Consequences of Performance-Enhancing Drugs</a> </li> <li class="end-lp-secondary-nav__subitem "> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/compounded-bioidentical-hormones-in-endocrinology-practice" id="4f6428d5-14ad-43bb-9b5b-72df466a7201">Compounded Bioidentical Hormones in Endocrinology Practice</a> </li> <li class="end-lp-secondary-nav__subitem "> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/edc2" id="96a86ed9-1ef5-4cd6-9eb7-6aa23d3c71e0">Endocrine-Disrupting Chemicals 2</a> </li> <li class="end-lp-secondary-nav__subitem "> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/polycystic-ovary-syndrome" id="24185cb3-2ccf-43d6-937d-48b81001f1ba">Polycystic Ovary Syndrome</a> </li> <li class="end-lp-secondary-nav__subitem "> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/health-disparities-in-endocrine-disorders" id="840245fe-179a-4592-bcb5-e46f9c20c724">Health Disparities in Endocrine Disorders: Biological, Clinical, and Nonclinical Factors</a> </li> <li class="end-lp-secondary-nav__subitem "> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/nonskeletal-effects-of-vitamin-d" id="4a0bba88-7b9e-4d4b-8060-251570b2b9b3">Nonskeletal Effects of Vitamin D: An Endocrine Society Scientific Statement</a> </li> <li class="end-lp-secondary-nav__subitem "> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/postmenopausal-hormone-therapy" id="3cbc72fe-cdbc-4e37-b66c-4368417458b4">Postmenopausal Hormone Therapy</a> </li> <li class="end-lp-secondary-nav__subitem "> <a href="/web/20210214102730/https://www.endocrine.org/advancing-research/scientific-statements/edc" 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/web/20210214102730im_/https://www.endocrine.org/-/media/endocrine/images/iamendocrinology/emilia_modolo_pinto.jpg?w=760&hash=B23334420440307039CE271D218D3371 2x" media="(min-width: 56.9375em)"> <source srcset="/web/20210214102730im_/https://www.endocrine.org/-/media/endocrine/images/iamendocrinology/emilia_modolo_pinto.jpg?w=260&hash=FF419484D4A5FC2F3CE659D7F3DB93C5 1x, /web/20210214102730im_/https://www.endocrine.org/-/media/endocrine/images/iamendocrinology/emilia_modolo_pinto.jpg?w=520&hash=DC651A5B74ADD0D6B7A9B60B6897FA70 2x" media="(min-width: 29.4375em)"> <source srcset="/web/20210214102730im_/https://www.endocrine.org/-/media/endocrine/images/iamendocrinology/emilia_modolo_pinto.jpg?w=470&hash=DFADDEB75AEB8C2BF952668EE7B125C3 1x, /web/20210214102730im_/https://www.endocrine.org/-/media/endocrine/images/iamendocrinology/emilia_modolo_pinto.jpg?w=940&hash=16CDDA050391F2E30B3029D1862954DC 2x" media="(min-width: 29.375em)"> <img src="/web/20210214102730im_/https://www.endocrine.org/-/media/endocrine/images/iamendocrinology/emilia_modolo_pinto.jpg?la=en&h=380&w=380&mw=380&hash=7E72F6D154F8BA0C4525F2A961F31A26" srcset="/web/20210214102730im_/https://www.endocrine.org/-/media/endocrine/images/iamendocrinology/emilia_modolo_pinto.jpg?w=380&hash=8FFCB06A099B82E4EA3D4E8E2945860D 1x" alt="Emilia Modolo Pinto"/> </picture> </a> <figcaption class="u-visuallyhidden">"In the coming years, I hope to widen my horizons and spread awareness and knowledge about adrenocortical tumorigenesis, not just among my peers and students but also patients and healthcare professionals across the world."</figcaption> </figure> <div class="end-promo__content"> <div class="end-promo__content-header"> <div class="end-promo__eyebrow">Member Spotlight</div> <a href="https://web.archive.org/web/20210214102730/https://endocrinenews.endocrine.org/expanding-horizons-research-adrenocortical-tumors/"> <h2 class="end-promo__title"> Expanding Horizons in Research on Adrenocortical Tumors</h2> </a> </div> <h3 class="end-promo__subtitle"> Emilia Modolo Pinto, Ph.D.</h3> <p class="end-promo__description">"In the coming years, I hope to widen my horizons and spread awareness and knowledge about adrenocortical tumorigenesis, not just among my peers and students but also patients and healthcare professionals across the world."</p> <div class="end-promo__cta"> <a href="https://web.archive.org/web/20210214102730/https://endocrinenews.endocrine.org/expanding-horizons-research-adrenocortical-tumors/"> <span class="end-promo__cta-text">Your Stories </span> <span class="see-more-arrow"></span> </a> </div> </div> </section> <section class="end-promo "> <header class="end-promo__top-header"> <div class="end-promo__eyebrow">Endocrine News Podcast</div> <a href="/web/20210214102730/https://www.endocrine.org/podcast/enp21-getting-published"> <h2 class="end-promo__title"> Advice for Getting Published</h2> </a> </header> <figure class="end-promo__media"> <a href="/web/20210214102730/https://www.endocrine.org/podcast/enp21-getting-published"> <picture> <source srcset="/web/20210214102730im_/https://www.endocrine.org/-/media/endocrine/images/profiles/gore_andrea.jpg?w=380&hash=C7799945207BFCD50ADAD55B5EEC7A51 1x, /web/20210214102730im_/https://www.endocrine.org/-/media/endocrine/images/profiles/gore_andrea.jpg?w=760&hash=AC37EA9F921CB7D2FB42DA0DB7D2CE75 2x" media="(min-width: 56.9375em)"> <source srcset="/web/20210214102730im_/https://www.endocrine.org/-/media/endocrine/images/profiles/gore_andrea.jpg?w=260&hash=616E609B74968F31C1FE8BFCEF34147C 1x, /web/20210214102730im_/https://www.endocrine.org/-/media/endocrine/images/profiles/gore_andrea.jpg?w=520&hash=9F078F66D053948DEAD8632CFC7357EC 2x" media="(min-width: 29.4375em)"> <source srcset="/web/20210214102730im_/https://www.endocrine.org/-/media/endocrine/images/profiles/gore_andrea.jpg?w=470&hash=B51DE8729CB16EB4BE96AE3A4F0F3811 1x, /web/20210214102730im_/https://www.endocrine.org/-/media/endocrine/images/profiles/gore_andrea.jpg?w=940&hash=10E12C781F2C277C6156594EDAB92E56 2x" media="(min-width: 29.375em)"> <img src="/web/20210214102730im_/https://www.endocrine.org/-/media/endocrine/images/profiles/gore_andrea.jpg?la=en&h=380&w=330&mw=380&hash=D7ABB7DCBFDC85CD4A187846E671138F" srcset="/web/20210214102730im_/https://www.endocrine.org/-/media/endocrine/images/profiles/gore_andrea.jpg?w=380&hash=C7799945207BFCD50ADAD55B5EEC7A51 1x" alt="Andrea Gore, PhD"/> </picture> </a> <figcaption class="u-visuallyhidden">Getting published can be a challenging journey. Andrea Gore, Ph.D., from the University of Texas at Austin talks about what makes for a well-written scientific paper and about the peer review process: what to expect and how to understand the feedback from editors.</figcaption> </figure> <div class="end-promo__content"> <div class="end-promo__content-header"> <div class="end-promo__eyebrow">Endocrine News Podcast</div> <a href="/web/20210214102730/https://www.endocrine.org/podcast/enp21-getting-published"> <h2 class="end-promo__title"> Advice for Getting Published</h2> </a> </div> <p class="end-promo__description">Getting published can be a challenging journey. Andrea Gore, Ph.D., from the University of Texas at Austin talks about what makes for a well-written scientific paper and about the peer review process: what to expect and how to understand the feedback from editors.</p> <div class="end-promo__cta"> <a href="/web/20210214102730/https://www.endocrine.org/podcast/enp21-getting-published"> <span class="end-promo__cta-text">Listen up... </span> <span class="see-more-arrow"></span> </a> </div> </div> </section> <section class="end-promo "> <header class="end-promo__top-header"> <div class="end-promo__eyebrow">Store</div> <a href="/web/20210214102730/https://www.endocrine.org/store/gifts-and-apparel/endocrine-socks"> <h2 class="end-promo__title"> New Gland Socks</h2> </a> </header> <figure class="end-promo__media"> <a href="/web/20210214102730/https://www.endocrine.org/store/gifts-and-apparel/endocrine-socks"> <picture> <source srcset="/web/20210214102730im_/https://www.endocrine.org/-/media/endosociety/images/store/gifts-and-apparel/sockglands.jpg?w=380&hash=B4F670CA3E70EA48954E80053E1F5FB7 1x, /web/20210214102730im_/https://www.endocrine.org/-/media/endosociety/images/store/gifts-and-apparel/sockglands.jpg?w=760&hash=E8EAD44BF63540AA26914F82A1BE04D4 2x" media="(min-width: 56.9375em)"> <source srcset="/web/20210214102730im_/https://www.endocrine.org/-/media/endosociety/images/store/gifts-and-apparel/sockglands.jpg?w=260&hash=A8164B3EECE9F3CA0C4199D00E554B2D 1x, /web/20210214102730im_/https://www.endocrine.org/-/media/endosociety/images/store/gifts-and-apparel/sockglands.jpg?w=520&hash=E788EBAA4C971F4714E9A86AD1EA98E1 2x" media="(min-width: 29.4375em)"> <source srcset="/web/20210214102730im_/https://www.endocrine.org/-/media/endosociety/images/store/gifts-and-apparel/sockglands.jpg?w=470&hash=91CCC2EFD98AD791DB4F8BAF4CBAA6B5 1x, /web/20210214102730im_/https://www.endocrine.org/-/media/endosociety/images/store/gifts-and-apparel/sockglands.jpg?w=940&hash=FAEC0994CC854DB3393FC89BAD777B95 2x" media="(min-width: 29.375em)"> <img src="/web/20210214102730im_/https://www.endocrine.org/-/media/endosociety/images/store/gifts-and-apparel/sockglands.jpg?la=en&h=500&w=373&mw=380&hash=C5F9418574C0E1F2FA7C36C893C86990" srcset="/web/20210214102730im_/https://www.endocrine.org/-/media/endosociety/images/store/gifts-and-apparel/sockglands.jpg?w=380&hash=B4F670CA3E70EA48954E80053E1F5FB7 1x" alt=""/> </picture> </a> <figcaption class="u-visuallyhidden">We know you've heard of wearing your heart on your sleeve, but what about wearing your glands on your feet? 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