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class="vector-toc-list"> <li id="toc-Mutations_of_STAT1" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Mutations_of_STAT1"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1</span> <span>Mutations of STAT1</span> </div> </a> <ul id="toc-Mutations_of_STAT1-sublist" class="vector-toc-list"> <li id="toc-Loss_of_function" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Loss_of_function"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1.1</span> <span>Loss of function</span> </div> </a> <ul id="toc-Loss_of_function-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Gain_of_function" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Gain_of_function"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1.2</span> <span>Gain of function</span> </div> </a> <ul id="toc-Gain_of_function-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </li> <li id="toc-Interactions" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Interactions"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Interactions</span> </div> </a> <ul id="toc-Interactions-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" 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lang="cy" hreflang="cy" data-title="STAT1" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/STAT1" title="STAT1 – Persian" lang="fa" hreflang="fa" data-title="STAT1" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/STAT1" title="STAT1 – Korean" lang="ko" hreflang="ko" data-title="STAT1" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/STAT-1" title="STAT-1 – Indonesian" lang="id" hreflang="id" data-title="STAT-1" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%B7%E3%82%B0%E3%83%8A%E3%83%AB%E4%BC%9D%E9%81%94%E5%85%BC%E8%BB%A2%E5%86%99%E6%B4%BB%E6%80%A7%E5%8C%96%E5%9B%A0%E5%AD%901" title="シグナル伝達兼転写活性化因子1 – Japanese" lang="ja" hreflang="ja" data-title="シグナル伝達兼転写活性化因子1" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/STAT1" title="STAT1 – Russian" lang="ru" hreflang="ru" data-title="STAT1" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/STAT1" title="STAT1 – Tatar" lang="tt" hreflang="tt" data-title="STAT1" data-language-autonym="Татарча / tatarça" data-language-local-name="Tatar" class="interlanguage-link-target"><span>Татарча / tatarça</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/STAT1" title="STAT1 – Ukrainian" lang="uk" hreflang="uk" data-title="STAT1" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/STAT1" title="STAT1 – Chinese" lang="zh" hreflang="zh" data-title="STAT1" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q14912030#sitelinks-wikipedia" title="Edit interlanguage links" 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</div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to 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style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:Stat1_stucture.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/30/Stat1_stucture.png/250px-Stat1_stucture.png" decoding="async" width="250" height="113" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/30/Stat1_stucture.png/375px-Stat1_stucture.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/30/Stat1_stucture.png/500px-Stat1_stucture.png 2x" data-file-width="600" data-file-height="270" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P42225%20or%20P42224%20or%20H7BZB5">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P42225,P42224,H7BZB5">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3WWT">3WWT</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1BF5">1BF5</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1YVL">1YVL</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2KA6">2KA6</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/11362">STAT1</a></span>, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/600555">600555</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:103063">103063</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=21428">21428</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=STAT1">STAT1</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000115415">STAT1 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_2.svg" class="mw-file-description" title="Chromosome 2 (human)"><img alt="Chromosome 2 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Ideogram_human_chromosome_2.svg/300px-Ideogram_human_chromosome_2.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Ideogram_human_chromosome_2.svg/450px-Ideogram_human_chromosome_2.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Ideogram_human_chromosome_2.svg/600px-Ideogram_human_chromosome_2.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_2_(human)" class="mw-redirect" title="Chromosome 2 (human)">Chromosome 2 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_2_ideogram.svg" class="mw-file-description" title="Chromosome 2 (human)"><img alt="Chromosome 2 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/77/Human_chromosome_2_ideogram.svg/300px-Human_chromosome_2_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/77/Human_chromosome_2_ideogram.svg/450px-Human_chromosome_2_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/77/Human_chromosome_2_ideogram.svg/600px-Human_chromosome_2_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 226.51809240854px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for STAT1"><img alt="Genomic location for STAT1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 232.5px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for STAT1"><img alt="Genomic location for STAT1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">2q32.2</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">190,908,460 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">191,020,960 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_1.svg" class="mw-file-description" title="Chromosome 1 (mouse)"><img alt="Chromosome 1 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Ideogram_house_mouse_chromosome_1.svg/260px-Ideogram_house_mouse_chromosome_1.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Ideogram_house_mouse_chromosome_1.svg/390px-Ideogram_house_mouse_chromosome_1.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Ideogram_house_mouse_chromosome_1.svg/520px-Ideogram_house_mouse_chromosome_1.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 1 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_1.svg" class="mw-file-description" title="Chromosome 1 (mouse)"><img alt="Chromosome 1 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Ideogram_of_house_mouse_chromosome_1.svg/300px-Ideogram_of_house_mouse_chromosome_1.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Ideogram_of_house_mouse_chromosome_1.svg/450px-Ideogram_of_house_mouse_chromosome_1.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Ideogram_of_house_mouse_chromosome_1.svg/600px-Ideogram_of_house_mouse_chromosome_1.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 73.116704228105px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for STAT1"><img alt="Genomic location for STAT1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 79.1px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for STAT1"><img alt="Genomic location for STAT1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">1 C1.1|1 26.81 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">52,158,599 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">52,201,024 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000115415">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">epithelium of nasopharynx</li><br /><li style="line-height: 137%;">appendix</li><br /><li style="line-height: 137%;">mononuclear cell</li><br /><li style="line-height: 137%;">monocyte</li><br /><li style="line-height: 137%;">decidua</li><br /><li style="line-height: 137%;">endothelial cell</li><br /><li style="line-height: 137%;">lymph node</li><br /><li style="line-height: 137%;">glomerulus</li><br /><li style="line-height: 137%;">granulocyte</li><br /><li style="line-height: 137%;">metanephric glomerulus</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000026104">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">granulocyte</li><br /><li style="line-height: 137%;">thymus</li><br /><li style="line-height: 137%;">spleen</li><br /><li style="line-height: 137%;">mesenteric lymph nodes</li><br /><li style="line-height: 137%;">gastrula</li><br /><li style="line-height: 137%;">submandibular gland</li><br /><li style="line-height: 137%;">blood</li><br /><li style="line-height: 137%;">epithelium of lens</li><br /><li style="line-height: 137%;">subcutaneous adipose tissue</li><br /><li style="line-height: 137%;">mucous cell of stomach</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000115415">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_STAT1_200887_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/PBB_GE_STAT1_200887_s_at_fs.png/250px-PBB_GE_STAT1_200887_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/PBB_GE_STAT1_200887_s_at_fs.png/375px-PBB_GE_STAT1_200887_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4e/PBB_GE_STAT1_200887_s_at_fs.png/500px-PBB_GE_STAT1_200887_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/6772/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003677">DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042803">protein homodimerization activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003700">DNA-binding transcription factor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016251">RNA polymerase II general transcription initiation factor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/">signal transducer activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000978">RNA polymerase II cis-regulatory region sequence-specific DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042802">identical protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019899">enzyme binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005164">tumor necrosis factor receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003690">double-stranded DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000979">RNA polymerase II core promoter sequence-specific DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045296">cadherin binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035035">histone acetyltransferase binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042393">histone binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044389">ubiquitin-like protein ligase binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1990841">promoter-specific chromatin binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043565">sequence-specific DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000981">DNA-binding transcription factor activity, RNA polymerase II-specific</a></li> <li><a href="https://www.wikidata.org/wiki/Q14864824" class="extiw" title="d:Q14864824">transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031730">CCR5 chemokine receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051721">protein phosphatase 2A binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001228">DNA-binding transcription activator activity, RNA polymerase II-specific</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005654">nucleoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005730">nucleolus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048471">perinuclear region of cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030424">axon</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030425">dendrite</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032991">protein-containing complex</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042981">regulation of apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0072136">metanephric mesenchymal cell proliferation involved in metanephros development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006355">regulation of transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035458">cellular response to interferon-beta</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006357">regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003340">negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0072162">metanephric mesenchymal cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033209">tumor necrosis factor-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000122">negative regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0061326">renal tubule development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035456">response to interferon-beta</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043124">negative regulation of I-kappaB kinase/NF-kappaB signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006351">transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001937">negative regulation of endothelial cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060338">regulation of type I interferon-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060334">regulation of interferon-gamma-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002053">positive regulation of mesenchymal cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0072308">negative regulation of metanephric nephron tubule epithelial cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016525">negative regulation of angiogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046725">negative regulation by virus of viral protein levels in host cell</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016032">viral process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043542">endothelial cell migration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045944">positive regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007165">signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010742">macrophage derived foam cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045648">positive regulation of erythrocyte differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060337">type I interferon signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071346">cellular response to interferon-gamma</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002230">positive regulation of defense response to virus by host</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032727">positive regulation of interferon-alpha production</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045893">positive regulation of transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051607">defense response to virus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060333">interferon-gamma-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007259">receptor signaling pathway via JAK-STAT</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007584">response to nutrient</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008015">blood circulation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008284">positive regulation of cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009612">response to mechanical stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0014070">response to organic cyclic compound</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032869">cellular response to insulin stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034097">response to cytokine</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042542">response to hydrogen peroxide</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043434">response to peptide hormone</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048661">positive regulation of smooth muscle cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051591">response to cAMP</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051770">positive regulation of nitric-oxide synthase biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071345">cellular response to cytokine stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071407">cellular response to organic cyclic compound</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007221">positive regulation of transcription of Notch receptor target</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019221">cytokine-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0038114">interleukin-21-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070102">interleukin-6-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070106">interleukin-27-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070757">interleukin-35-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0038113">interleukin-9-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006952">defense response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042127">regulation of cell population proliferation</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=6772&rn=1">6772</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=20846&rn=1">20846</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000115415;db=core">ENSG00000115415</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000026104;db=core">ENSMUSG00000026104</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P42224">P42224</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P42225">P42225</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_007315">NM_007315</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_139266">NM_139266</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001205313">NM_001205313</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001205314">NM_001205314</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_009283">NM_009283</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001357627">NM_001357627</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_009330">NP_009330</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_644671">NP_644671</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks">n/a</span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr2:190908460-191020960">Chr 2: 190.91 – 191.02 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr1:52158599-52201024">Chr 1: 52.16 – 52.2 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14912030" class="extiw" title="d:Q14912030">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14912031" class="extiw" title="d:Q14912031">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Signal transducer and activator of transcription 1</b> (<b>STAT1</b>) is a <a href="/wiki/Transcription_factor" title="Transcription factor">transcription factor</a> which in humans is encoded by the <i>STAT1</i> <a href="/wiki/Gene" title="Gene">gene</a>. It is a member of the <a href="/wiki/STAT_protein" title="STAT protein">STAT protein</a> family.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=STAT1&action=edit&section=1" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>All STAT molecules are phosphorylated by receptor associated kinases, that causes activation, dimerization by forming homo- or heterodimers and finally translocate to nucleus to work as transcription factors. Specifically STAT1 can be activated by several ligands such as Interferon alpha (IFNα), Interferon gamma (IFNγ), Epidermal Growth Factor (EGF), Platelet Derived Growth Factor (PDGF), Interleukin 6 (IL-6), or IL-27.<sup id="cite_ref-:0_6-0" class="reference"><a href="#cite_note-:0-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p><a href="/wiki/Interferon_type_I" title="Interferon type I">Type I interferons</a> (IFN-α, IFN-ß) bind to receptors, cause signaling via kinases, phosphorylate and activate the Jak kinases TYK2 and JAK1 and also STAT1 and STAT2. STAT molecules form dimers and bind to ISGF3G/IRF-9, which is Interferon stimulated gene factor 3 complex with Interferon regulatory Factor 9.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> This allows STAT1 to enter the nucleus.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> STAT1 has a key role in many gene expressions that cause survival of the cell, viability or pathogen response. There are two possible transcripts (due to alternative splicing) that encode 2 isoforms of STAT1.<sup id="cite_ref-uniprot_9-0" class="reference"><a href="#cite_note-uniprot-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> STAT1α, the full-length version of the protein, is the main active isoform, responsible for most of the known functions of STAT1. STAT1ß, which lacks a portion of the C-terminus of the protein, is less-studied, but has variously been reported to negatively regulate activation of STAT1 or to mediate IFN-γ-dependent anti-tumor and anti-infection activities.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p><p>STAT1 is involved in upregulating genes due to a signal by either <a href="/wiki/Interferon_type_I" title="Interferon type I">type I</a>, <a href="/wiki/Interferon_type_II" class="mw-redirect" title="Interferon type II">type II</a>, or <a href="/wiki/Interferon_type_III" title="Interferon type III">type III</a> <a href="/wiki/Interferons" class="mw-redirect" title="Interferons">interferons</a>. In response to <a href="/wiki/Interferon-gamma" class="mw-redirect" title="Interferon-gamma">IFN-γ</a> stimulation, STAT1 forms homodimers or heterodimers with <a href="/wiki/STAT3" title="STAT3">STAT3</a> that bind to the <b>GAS</b> (Interferon-<b>G</b>amma-<b>A</b>ctivated <b>S</b>equence) promoter element; in response to either <a href="/wiki/Interferon_type_I" title="Interferon type I">IFN-α or IFN-β</a> stimulation, STAT1 forms a heterodimer with <a href="/wiki/STAT2" title="STAT2">STAT2</a> that can bind the <b>ISRE</b> (<b>I</b>nterferon-<b>S</b>timulated <b>R</b>esponse <b>E</b>lement) promoter element.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> In either case, binding of the promoter element leads to an increased expression of <b>ISG</b> (<b>I</b>nterferon-<b>S</b>timulated <b>G</b>enes). </p><p>Expression of STAT1 can be induced with <a href="/wiki/Diallyl_disulfide" title="Diallyl disulfide">diallyl disulfide</a>, a compound in garlic.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Mutations_of_STAT1">Mutations of STAT1</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=STAT1&action=edit&section=2" title="Edit section: Mutations of STAT1"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Mutations in the STAT1 molecule can be gain of function (GOF) or loss of function (LOF). Both of them can cause different phenotypes and symptoms. Recurring common infections are frequent in both GOF and LOF mutations. In humans STAT1 has been particularly under strong purifying selection when populations shifted from hunting and gathering to farming, because this went along with a change in the pathogen spectrum.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Loss_of_function">Loss of function</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=STAT1&action=edit&section=3" title="Edit section: Loss of function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>STAT1 loss of function, therefore STAT1 deficiency can have many variants. There are two main genetic impairments that can cause response to interferons type I and III. First there can be autosomal recessive partial or even complete deficiency of STAT1. That causes intracellular bacterial diseases or viral infections and impaired IFN a, b, g and IL27 responses are diagnosed. In partial form there can also be found high levels of IFNg in blood serum. When tested from whole blood, monocytes do not respond to BCG and IFNg doses with IL-12 production. In complete recessive form there is a very low response to anti-viral and antimycotical medication. Second, partial STAT1 deficiency can also be an autosomal dominant mutation; phenotypically causing impaired IFNg responses and causing patients to suffer with selective intracellular bacterial diseases (MSMD).<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p><p>In knock-out mice prepared in the 90s, a low amount of CD4<sup>+</sup> and CD25<sup>+</sup> regulatory T-cells and almost no IFNa, b and g response was discovered, which lead to parasital, viral and bacterial infections. The very first reported case of STAT1 deficiency in human was an autosomal dominant mutation and patients were showing propensity to mycobacterial infections.<sup id="cite_ref-uniprot_9-1" class="reference"><a href="#cite_note-uniprot-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Another case reported was about an autosomal recessive form. 2 related patients had a homozygous missense STAT1 mutation which caused impaired splicing, therefore a defect in mature protein. Patients had partially damaged response to both IFNa and IFNg. Scientists now claim that recessive STAT1 deficiency is a new form of primary immunodeficiency and whenever a patient suffers sudden, severe and unexpected bacterial and viral infections, should be considered as potentially STAT1 deficient.<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p><p><a href="/wiki/Interferons" class="mw-redirect" title="Interferons">Interferons</a> induce the formation of two transcriptional activators: gamma-activating factor (GAF) and interferon-stimulated gamma factor 3 (ISGF3). A natural heterozygous germline STAT1 mutation associated with susceptibility to mycobacterial but not viral disease was found in two unrelated patients with unexplained mycobacterial disease.<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> This <a href="/wiki/Mutation" title="Mutation">mutation</a> caused a loss of GAF and ISGF3 activation but was dominant for one cellular <a href="/wiki/Phenotype" title="Phenotype">phenotype</a> and recessive for the other. It impaired the nuclear accumulation of GAF but not of ISGF3 in cells stimulated by interferons, implying that the antimycobacterial but not the antiviral effects of human interferons are mediated by GAF. More recently, two patients have been identified with homozygous STAT-1 mutations who developed both post–BCG vaccination disseminated disease and lethal viral infections. The mutations in these patients caused a complete lack of STAT-1 and resulted in a lack of formation of both GAF and ISGF3.<sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Gain_of_function">Gain of function</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=STAT1&action=edit&section=4" title="Edit section: Gain of function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Gain of function mutation was first discovered in patients with chronic mucocutaneous candidiasis (CMC). This disease is characteristic with its symptoms as persistent infections of the skin, mucosae - oral or genital and nails infections caused by <i>Candida</i>, mostly <i><a href="/wiki/Candida_albicans" title="Candida albicans">Candida albicans</a></i>. CMC may very often result from primary immunodeficiency. Patients with CMC often suffer also with bacterial infections (mostly <i><a href="/wiki/Staphylococcus_aureus" title="Staphylococcus aureus">Staphylococcus aureus</a></i>), also with infections of the respiratory system and skin. In these patients we can also find viral infections caused mostly by <a href="/wiki/Herpesviridae" title="Herpesviridae">Herpesviridae</a>, that also affect the skin. The mycobacterial infections are often caused by <i><a href="/wiki/Mycobacterium_tuberculosis" title="Mycobacterium tuberculosis">Mycobacterium tuberculosis</a></i> or environmental bacteria. Very common are also autoimmune symptoms like type 1 <a href="/wiki/Diabetes" title="Diabetes">diabetes</a>, cytopenia, regression of the <a href="/wiki/Thymus" title="Thymus">thymus</a> or <a href="/wiki/Systemic_lupus_erythematosus" class="mw-redirect" title="Systemic lupus erythematosus">systemic lupus erythematosus</a>. When T-cell deficient, these autoimmune díseases are very common. CMC was also reported as a common symptom in patients with hyper immunoglobulin E syndrome (hyper-IgE) and with <a href="/wiki/Autoimmune_polyendocrine_syndrome" title="Autoimmune polyendocrine syndrome">autoimmune polyendocrine syndrome</a> type I. There was reported an interleukin 17A role, because of low levels of IL-17A producing T-cells in CMC patients. </p><p>With various genomic and genetic methods was discovered, that a heterozygous gain of function mutation of STAT1 is a cause of more than a half CMC cases. This mutation is caused by defect in the coiled-coil domain, domain that binds DNA, N-terminal domain or SH2 domain. Because of this there is increased phosphorylation because of impossible dephosphorylation in nucleus. These processes are dependent on cytokines like interferon alpha or beta, interferon gamma or interleukin 27. As mentioned above, low levels of interleukin 17A were observed, therefore impaired the Th17 polarization of the immune response. </p><p>Patients with STAT1 gain of function mutation and CMC poorly or not at all respond to treatment with azole drugs such as <a href="/wiki/Fluconazole" title="Fluconazole">Fluconazole</a>, <a href="/wiki/Itraconazole" title="Itraconazole">Itraconazole</a> or <a href="/wiki/Posaconazole" title="Posaconazole">Posaconazole</a>. Besides common viral and bacterial infections, these patients develop autoimmunities or even carcinomas. It is very complicated to find a treatment because of various symptoms and resistances, inhibitors of JAK/STAT pathway such as <a href="/wiki/Ruxolitinib" title="Ruxolitinib">Ruxolitinib</a> are being tested and are a possible choice of treatment for these patients.<sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:0_6-1" class="reference"><a href="#cite_note-:0-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=STAT1&action=edit&section=5" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>STAT1 has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with: </p> <style data-mw-deduplicate="TemplateStyles:r1184024115">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/BRCA1" title="BRCA1">BRCA1</a>,<sup id="cite_ref-pmid10792030_24-0" class="reference"><a href="#cite_note-pmid10792030-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/C-jun" class="mw-redirect" title="C-jun">C-jun</a>,<sup id="cite_ref-pmid10490649_25-0" class="reference"><a href="#cite_note-pmid10490649-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/CD117" class="mw-redirect" title="CD117">CD117</a>,<sup id="cite_ref-pmid9355737_26-0" class="reference"><a href="#cite_note-pmid9355737-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/CREB-binding_protein" title="CREB-binding protein">CREB-binding protein</a>,<sup id="cite_ref-pmid8986769_27-0" class="reference"><a href="#cite_note-pmid8986769-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Calcitriol_receptor" class="mw-redirect" title="Calcitriol receptor">Calcitriol receptor</a>,<sup id="cite_ref-pmid11909970_28-0" class="reference"><a href="#cite_note-pmid11909970-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">Epidermal growth factor receptor</a>,<sup id="cite_ref-pmid10358079_29-0" class="reference"><a href="#cite_note-pmid10358079-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12070153_30-0" class="reference"><a href="#cite_note-pmid12070153-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Fanconi_anemia,_complementation_group_C" title="Fanconi anemia, complementation group C">Fanconi anemia, complementation group C</a>,<sup id="cite_ref-pmid10848598_31-0" class="reference"><a href="#cite_note-pmid10848598-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid14499622_32-0" class="reference"><a href="#cite_note-pmid14499622-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11520787_33-0" class="reference"><a href="#cite_note-pmid11520787-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/GNB2L1" class="mw-redirect" title="GNB2L1">GNB2L1</a>,<sup id="cite_ref-pmid11301323_34-0" class="reference"><a href="#cite_note-pmid11301323-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12960323_35-0" class="reference"><a href="#cite_note-pmid12960323-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/IFNAR2" title="IFNAR2">IFNAR2</a>,<sup id="cite_ref-pmid11301323_34-1" class="reference"><a href="#cite_note-pmid11301323-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9121453_36-0" class="reference"><a href="#cite_note-pmid9121453-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/IRF1" title="IRF1">IRF1</a>,<sup id="cite_ref-pmid10764778_37-0" class="reference"><a href="#cite_note-pmid10764778-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/ISGF3G" class="mw-redirect" title="ISGF3G">ISGF3G</a><sup id="cite_ref-pmid8943351_38-0" class="reference"><a href="#cite_note-pmid8943351-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Interleukin_27_receptor,_alpha_subunit" title="Interleukin 27 receptor, alpha subunit">Interleukin 27 receptor, alpha subunit</a>,<sup id="cite_ref-pmid12734330_39-0" class="reference"><a href="#cite_note-pmid12734330-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/MCM5" title="MCM5">MCM5</a>,<sup id="cite_ref-pmid9843502_40-0" class="reference"><a href="#cite_note-pmid9843502-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11248027_41-0" class="reference"><a href="#cite_note-pmid11248027-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Mammalian_target_of_rapamycin" class="mw-redirect" title="Mammalian target of rapamycin">Mammalian target of rapamycin</a>,<sup id="cite_ref-pmid12807916_42-0" class="reference"><a href="#cite_note-pmid12807916-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PIAS1" title="PIAS1">PIAS1</a>,<sup id="cite_ref-pmid10805787_43-0" class="reference"><a href="#cite_note-pmid10805787-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PRKCD" title="PRKCD">PRKCD</a>,<sup id="cite_ref-pmid12807916_42-1" class="reference"><a href="#cite_note-pmid12807916-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PTK2" title="PTK2">PTK2</a>,<sup id="cite_ref-pmid11278462_44-0" class="reference"><a href="#cite_note-pmid11278462-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Protein_kinase_R" title="Protein kinase R">Protein kinase R</a>,<sup id="cite_ref-pmid9135145_45-0" class="reference"><a href="#cite_note-pmid9135145-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11278865_46-0" class="reference"><a href="#cite_note-pmid11278865-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/STAT2" title="STAT2">STAT2</a>,<sup id="cite_ref-pmid8621447_47-0" class="reference"><a href="#cite_note-pmid8621447-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10446176_48-0" class="reference"><a href="#cite_note-pmid10446176-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12048190_49-0" class="reference"><a href="#cite_note-pmid12048190-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/STAT3" title="STAT3">STAT3</a>,<sup id="cite_ref-pmid12070153_30-1" class="reference"><a href="#cite_note-pmid12070153-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11594781_50-0" class="reference"><a href="#cite_note-pmid11594781-50"><span class="cite-bracket">[</span>50<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11722592_51-0" class="reference"><a href="#cite_note-pmid11722592-51"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Src_(gene)" class="mw-redirect" title="Src (gene)">Src</a>,<sup id="cite_ref-pmid10358079_29-1" class="reference"><a href="#cite_note-pmid10358079-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9344858_52-0" class="reference"><a href="#cite_note-pmid9344858-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup> and</li> <li><a href="/wiki/TRADD" title="TRADD">TRADD</a>.<sup id="cite_ref-pmid10848577_53-0" class="reference"><a href="#cite_note-pmid10848577-53"><span class="cite-bracket">[</span>53<span class="cite-bracket">]</span></a></sup></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=STAT1&action=edit&section=6" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 35em;"> <ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000115415">GRCh38: Ensembl release 89: ENSG00000115415</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000026104">GRCm38: Ensembl release 89: ENSMUSG00000026104</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=6772">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of 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class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11278865">11278865</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Enhanced+antiviral+and+antiproliferative+properties+of+a+STAT1+mutant+unable+to+interact+with+the+protein+kinase+PKR&rft.volume=276&rft.issue=17&rft.pages=13727-37&rft.date=2001-04&rft_id=info%3Adoi%2F10.1074%2Fjbc.M011240200&rft_id=info%3Apmid%2F11278865&rft.aulast=Wong&rft.aufirst=AH&rft.au=Durbin%2C+JE&rft.au=Li%2C+S&rft.au=Dever%2C+TE&rft.au=Decker%2C+T&rft.au=Koromilas%2C+AE&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M011240200&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASTAT1" class="Z3988"></span></span> </li> <li id="cite_note-pmid8621447-47"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid8621447_47-0">^</a></b></span> <span 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Formation+of+STAT1-STAT2+heterodimers+and+their+role+in+the+activation+of+IRF-1+gene+transcription+by+interferon-alpha&rft.volume=271&rft.issue=10&rft.pages=5790-4&rft.date=1996-03&rft_id=info%3Adoi%2F10.1074%2Fjbc.271.10.5790&rft_id=info%3Apmid%2F8621447&rft.aulast=Li&rft.aufirst=X&rft.au=Leung%2C+S&rft.au=Qureshi%2C+S&rft.au=Darnell%2C+JE&rft.au=Stark%2C+GR&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.271.10.5790&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASTAT1" class="Z3988"></span></span> </li> <li id="cite_note-pmid10446176-48"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid10446176_48-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDumlerKopmannWagnerMayboroda1999" class="citation journal cs1">Dumler I, Kopmann A, Wagner K, Mayboroda OA, Jerke U, Dietz R, Haller H, Gulba DC (August 1999). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.274.34.24059">"Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells"</a>. <i>The Journal of Biological Chemistry</i>. <b>274</b> (34): 24059–65. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.274.34.24059">10.1074/jbc.274.34.24059</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10446176">10446176</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Urokinase+induces+activation+and+formation+of+Stat4+and+Stat1-Stat2+complexes+in+human+vascular+smooth+muscle+cells&rft.volume=274&rft.issue=34&rft.pages=24059-65&rft.date=1999-08&rft_id=info%3Adoi%2F10.1074%2Fjbc.274.34.24059&rft_id=info%3Apmid%2F10446176&rft.aulast=Dumler&rft.aufirst=I&rft.au=Kopmann%2C+A&rft.au=Wagner%2C+K&rft.au=Mayboroda%2C+OA&rft.au=Jerke%2C+U&rft.au=Dietz%2C+R&rft.au=Haller%2C+H&rft.au=Gulba%2C+DC&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.274.34.24059&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASTAT1" class="Z3988"></span></span> </li> <li id="cite_note-pmid12048190-49"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid12048190_49-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFagerlundMélenKinnunenJulkunen2002" class="citation journal cs1">Fagerlund R, Mélen K, Kinnunen L, Julkunen I (August 2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M202943200">"Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5"</a>. <i>The Journal of Biological Chemistry</i>. <b>277</b> (33): 30072–8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M202943200">10.1074/jbc.M202943200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12048190">12048190</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Arginine%2Flysine-rich+nuclear+localization+signals+mediate+interactions+between+dimeric+STATs+and+importin+alpha+5&rft.volume=277&rft.issue=33&rft.pages=30072-8&rft.date=2002-08&rft_id=info%3Adoi%2F10.1074%2Fjbc.M202943200&rft_id=info%3Apmid%2F12048190&rft.aulast=Fagerlund&rft.aufirst=R&rft.au=M%C3%A9len%2C+K&rft.au=Kinnunen%2C+L&rft.au=Julkunen%2C+I&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M202943200&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASTAT1" class="Z3988"></span></span> </li> <li id="cite_note-pmid11594781-50"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11594781_50-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGunajeBhat2001" class="citation journal cs1">Gunaje JJ, Bhat GJ (October 2001). "Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin". <i>Biochemical and Biophysical Research Communications</i>. <b>288</b> (1): 252–7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fbbrc.2001.5759">10.1006/bbrc.2001.5759</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11594781">11594781</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Involvement+of+tyrosine+phosphatase+PTP1D+in+the+inhibition+of+interleukin-6-induced+Stat3+signaling+by+alpha-thrombin&rft.volume=288&rft.issue=1&rft.pages=252-7&rft.date=2001-10&rft_id=info%3Adoi%2F10.1006%2Fbbrc.2001.5759&rft_id=info%3Apmid%2F11594781&rft.aulast=Gunaje&rft.aufirst=JJ&rft.au=Bhat%2C+GJ&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASTAT1" class="Z3988"></span></span> </li> <li id="cite_note-pmid11722592-51"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11722592_51-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSpiekermannBiethahnWildeHiddemann2001" class="citation journal cs1">Spiekermann K, Biethahn S, Wilde S, Hiddemann W, Alves F (August 2001). "Constitutive activation of STAT transcription factors in acute myelogenous leukemia". <i>European Journal of Haematology</i>. <b>67</b> (2): 63–71. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1034%2Fj.1600-0609.2001.t01-1-00385.x">10.1034/j.1600-0609.2001.t01-1-00385.x</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11722592">11722592</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:38074766">38074766</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=European+Journal+of+Haematology&rft.atitle=Constitutive+activation+of+STAT+transcription+factors+in+acute+myelogenous+leukemia&rft.volume=67&rft.issue=2&rft.pages=63-71&rft.date=2001-08&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A38074766%23id-name%3DS2CID&rft_id=info%3Apmid%2F11722592&rft_id=info%3Adoi%2F10.1034%2Fj.1600-0609.2001.t01-1-00385.x&rft.aulast=Spiekermann&rft.aufirst=K&rft.au=Biethahn%2C+S&rft.au=Wilde%2C+S&rft.au=Hiddemann%2C+W&rft.au=Alves%2C+F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASTAT1" class="Z3988"></span></span> </li> <li id="cite_note-pmid9344858-52"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid9344858_52-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCirriChiarugiMarraRaugei1997" class="citation journal cs1">Cirri P, Chiarugi P, Marra F, Raugei G, Camici G, Manao G, Ramponi G (October 1997). "c-Src activates both STAT1 and STAT3 in PDGF-stimulated NIH3T3 cells". <i>Biochemical and Biophysical Research Communications</i>. <b>239</b> (2): 493–7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fbbrc.1997.7493">10.1006/bbrc.1997.7493</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9344858">9344858</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=c-Src+activates+both+STAT1+and+STAT3+in+PDGF-stimulated+NIH3T3+cells&rft.volume=239&rft.issue=2&rft.pages=493-7&rft.date=1997-10&rft_id=info%3Adoi%2F10.1006%2Fbbrc.1997.7493&rft_id=info%3Apmid%2F9344858&rft.aulast=Cirri&rft.aufirst=P&rft.au=Chiarugi%2C+P&rft.au=Marra%2C+F&rft.au=Raugei%2C+G&rft.au=Camici%2C+G&rft.au=Manao%2C+G&rft.au=Ramponi%2C+G&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASTAT1" class="Z3988"></span></span> </li> <li id="cite_note-pmid10848577-53"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid10848577_53-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWangWuCaiWelte2000" class="citation journal cs1">Wang Y, Wu TR, Cai S, Welte T, Chin YE (July 2000). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85828">"Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation"</a>. <i>Molecular and Cellular Biology</i>. <b>20</b> (13): 4505–12. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2Fmcb.20.13.4505-4512.2000">10.1128/mcb.20.13.4505-4512.2000</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85828">85828</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10848577">10848577</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=Stat1+as+a+component+of+tumor+necrosis+factor+alpha+receptor+1-TRADD+signaling+complex+to+inhibit+NF-kappaB+activation&rft.volume=20&rft.issue=13&rft.pages=4505-12&rft.date=2000-07&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC85828%23id-name%3DPMC&rft_id=info%3Apmid%2F10848577&rft_id=info%3Adoi%2F10.1128%2Fmcb.20.13.4505-4512.2000&rft.aulast=Wang&rft.aufirst=Y&rft.au=Wu%2C+TR&rft.au=Cai%2C+S&rft.au=Welte%2C+T&rft.au=Chin%2C+YE&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC85828&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASTAT1" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=STAT1&action=edit&section=7" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 35em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCebullaMillerSedmak2000" class="citation journal cs1">Cebulla CM, Miller DM, Sedmak DD (2000). "Viral inhibition of interferon signal transduction". <i>Intervirology</i>. <b>42</b> (5–6): 325–30. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1159%2F000053968">10.1159/000053968</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10702714">10702714</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:22135982">22135982</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Intervirology&rft.atitle=Viral+inhibition+of+interferon+signal+transduction&rft.volume=42&rft.issue=5%E2%80%936&rft.pages=325-30&rft.date=2000&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A22135982%23id-name%3DS2CID&rft_id=info%3Apmid%2F10702714&rft_id=info%3Adoi%2F10.1159%2F000053968&rft.aulast=Cebulla&rft.aufirst=CM&rft.au=Miller%2C+DM&rft.au=Sedmak%2C+DD&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASTAT1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKisselevaBhattacharyaBraunsteinSchindler2002" class="citation journal cs1">Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (February 2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges". <i>Gene</i>. <b>285</b> (1–2): 1–24. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0378-1119%2802%2900398-0">10.1016/S0378-1119(02)00398-0</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12039028">12039028</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Signaling+through+the+JAK%2FSTAT+pathway%2C+recent+advances+and+future+challenges&rft.volume=285&rft.issue=1%E2%80%932&rft.pages=1-24&rft.date=2002-02&rft_id=info%3Adoi%2F10.1016%2FS0378-1119%2802%2900398-0&rft_id=info%3Apmid%2F12039028&rft.aulast=Kisseleva&rft.aufirst=T&rft.au=Bhattacharya%2C+S&rft.au=Braunstein%2C+J&rft.au=Schindler%2C+CW&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASTAT1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFJosephKumarMitra2005" class="citation journal cs1">Joseph AM, Kumar M, Mitra D (January 2005). "Nef: "necessary and enforcing factor" in HIV infection". <i>Current HIV Research</i>. <b>3</b> (1): 87–94. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2174%2F1570162052773013">10.2174/1570162052773013</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15638726">15638726</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Current+HIV+Research&rft.atitle=Nef%3A+%22necessary+and+enforcing+factor%22+in+HIV+infection&rft.volume=3&rft.issue=1&rft.pages=87-94&rft.date=2005-01&rft_id=info%3Adoi%2F10.2174%2F1570162052773013&rft_id=info%3Apmid%2F15638726&rft.aulast=Joseph&rft.aufirst=AM&rft.au=Kumar%2C+M&rft.au=Mitra%2C+D&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASTAT1" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=STAT1&action=edit&section=8" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/ENCODE#FactorBook" title="ENCODE">FactorBook</a> <a rel="nofollow" class="external text" href="http://www.factorbook.org/mediawiki/index.php/STAT1">STAT1</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl 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srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f0/PDB_1bf5_EBI.jpg/270px-PDB_1bf5_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f0/PDB_1bf5_EBI.jpg/360px-PDB_1bf5_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1bf5</b>: TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1yvl_EBI.png" class="mw-file-description" title="1yvl: Structure of Unphosphorylated STAT1"><img alt="1yvl: Structure of Unphosphorylated STAT1" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/02/PDB_1yvl_EBI.png/180px-PDB_1yvl_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/02/PDB_1yvl_EBI.png/270px-PDB_1yvl_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/02/PDB_1yvl_EBI.png/360px-PDB_1yvl_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1yvl</b>: Structure of Unphosphorylated STAT1</div> </li> </ul></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Transcription_factors_and_intracellular_receptors" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3;"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Transcription_factors_and_intracellular_receptors" title="Template:Transcription factors and intracellular receptors"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Transcription_factors_and_intracellular_receptors" title="Template talk:Transcription factors and intracellular receptors"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Transcription_factors_and_intracellular_receptors" title="Special:EditPage/Template:Transcription factors and intracellular receptors"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Transcription_factors_and_intracellular_receptors" style="font-size:114%;margin:0 4em"><a href="/wiki/Transcription_factor" title="Transcription factor">Transcription factors</a> and <a href="/wiki/Intracellular_receptor" title="Intracellular receptor">intracellular receptors</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(1)_Basic_domains" style="font-size:114%;margin:0 4em"><i>(1) Basic domains</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.1) Basic</i> <a href="/wiki/Leucine_zipper" title="Leucine zipper">leucine zipper</a> (<a href="/wiki/BZIP_domain" title="BZIP domain">bZIP</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activating_transcription_factor" title="Activating transcription factor">Activating transcription factor</a> <ul><li><a href="/wiki/Apoptosis-antagonizing_transcription_factor" class="mw-redirect" title="Apoptosis-antagonizing transcription factor">AATF</a></li> <li><a href="/wiki/ATF1" title="ATF1">1</a></li> <li><a href="/wiki/Activating_transcription_factor_2" title="Activating transcription factor 2">2</a></li> <li><a href="/wiki/ATF3" title="ATF3">3</a></li> <li><a href="/wiki/ATF4" title="ATF4">4</a></li> <li><a href="/wiki/ATF5" title="ATF5">5</a></li> <li><a href="/wiki/ATF6" title="ATF6">6</a></li> <li><a href="/wiki/ATF7" title="ATF7">7</a></li></ul></li> <li><a href="/wiki/AP-1_transcription_factor" title="AP-1 transcription factor">AP-1</a> <ul><li><a href="/wiki/C-Fos" class="mw-redirect" title="C-Fos">c-Fos</a></li> <li><a href="/wiki/FOSB" title="FOSB">FOSB</a></li> <li><a href="/wiki/FOSL1" title="FOSL1">FOSL1</a></li> <li><a href="/wiki/FOSL2" title="FOSL2">FOSL2</a></li> <li><a href="/wiki/Jun_dimerization_protein" title="Jun dimerization protein">JDP2</a></li> <li><a href="/wiki/C-jun" class="mw-redirect" title="C-jun">c-Jun</a></li> <li><a href="/wiki/JUNB" title="JUNB">JUNB</a></li> <li><a href="/wiki/JunD" title="JunD">JunD</a></li></ul></li> <li><i>BACH</i> <ul><li><a href="/wiki/BACH1" title="BACH1">1</a></li> <li><a href="/wiki/BACH2" title="BACH2">2</a></li></ul></li> <li><a href="/wiki/BATF_(gene)" title="BATF (gene)">BATF</a></li> <li><a href="/wiki/BLZF1" title="BLZF1">BLZF1</a></li> <li><a href="/wiki/Ccaat-enhancer-binding_proteins" class="mw-redirect" title="Ccaat-enhancer-binding proteins">C/EBP</a> <ul><li><a href="/wiki/CEBPA" title="CEBPA">α</a></li> <li><a href="/wiki/CEBPB" title="CEBPB">β</a></li> <li><a href="/wiki/CEBPG" title="CEBPG">γ</a></li> <li><a href="/wiki/CEBPD" title="CEBPD">δ</a></li> <li><a href="/wiki/CEBPE" title="CEBPE">ε</a></li> <li><a href="/wiki/CCAAT/enhancer_binding_protein_zeta" title="CCAAT/enhancer binding protein zeta">ζ</a></li></ul></li> <li><a href="/wiki/CREB" title="CREB">CREB</a> <ul><li><a href="/wiki/CREB1" title="CREB1">1</a></li> <li><a href="/wiki/CREB3" title="CREB3">3</a></li> <li><a href="/wiki/CREBL1" title="CREBL1">L1</a></li></ul></li> <li><a href="/wiki/CAMP_responsive_element_modulator" title="CAMP responsive element modulator">CREM</a></li> <li><a href="/wiki/DBP_(gene)" title="DBP (gene)">DBP</a></li> <li><a href="/wiki/DNA_damage-inducible_transcript_3" title="DNA damage-inducible transcript 3">DDIT3</a></li> <li><a href="/wiki/GABPA" title="GABPA">GABPA</a></li> <li><a href="/wiki/Gcn4" title="Gcn4">GCN4</a></li> <li><a href="/wiki/HLF_(gene)" title="HLF (gene)">HLF</a></li> <li><a href="/wiki/MAF_(gene)" title="MAF (gene)">MAF</a> <ul><li><a href="/wiki/MAFB_(gene)" title="MAFB (gene)">B</a></li> <li><a href="/wiki/MAFF_(gene)" title="MAFF (gene)">F</a></li> <li><a href="/wiki/MAFG" title="MAFG">G</a></li> <li><a href="/wiki/MAFK" title="MAFK">K</a></li></ul></li> <li><i>NFE</i> <ul><li><a href="/wiki/NFE2" title="NFE2">2</a></li> <li><a href="/wiki/NFE2L1" title="NFE2L1">L1</a></li> <li><a href="/wiki/NFE2L2" title="NFE2L2">L2</a></li> <li><a href="/wiki/NFE2L3" title="NFE2L3">L3</a></li></ul></li> <li><a href="/wiki/NFIL3" title="NFIL3">NFIL3</a></li> <li><a href="/wiki/NRL_(gene)" title="NRL (gene)">NRL</a></li> <li><i>NRF</i> <ul><li><a href="/wiki/NRF1" title="NRF1">1</a></li> <li><a href="/wiki/NFE2L2" title="NFE2L2">2</a></li> <li><a href="/wiki/NFE2L3" title="NFE2L3">3</a></li></ul></li> <li><a href="/wiki/XBP1" title="XBP1">XBP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.2) Basic helix-loop-helix</i> (<a href="/wiki/Basic_helix-loop-helix" class="mw-redirect" title="Basic helix-loop-helix">bHLH</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group A</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Achaete-scute_complex" title="Achaete-scute complex">AS-C</a> <ul><li><a href="/wiki/ASCL1" title="ASCL1">ASCL1</a></li> <li><a href="/wiki/ASCL2" title="ASCL2">ASCL2</a></li></ul></li> <li><a href="/wiki/ATOH1" title="ATOH1">ATOH1</a></li> <li><i>HAND</i> <ul><li><a href="/wiki/HAND1" title="HAND1">1</a></li> <li><a href="/wiki/HAND2" title="HAND2">2</a></li></ul></li> <li><a href="/wiki/MESP2" title="MESP2">MESP2</a></li> <li><a href="/wiki/Myogenic_regulatory_factors" title="Myogenic regulatory factors">Myogenic regulatory factors</a> <ul><li><a href="/wiki/MyoD" title="MyoD">MyoD</a></li> <li><a href="/wiki/Myogenin" title="Myogenin">Myogenin</a></li> <li><a href="/wiki/MYF5" title="MYF5">MYF5</a></li> <li><a href="/wiki/MYF6" title="MYF6">MYF6</a></li></ul></li> <li><a href="/wiki/NeuroD" title="NeuroD">NeuroD</a> <ul><li><a href="/wiki/NEUROD1" title="NEUROD1">1</a></li> <li><a href="/wiki/NEUROD2" title="NEUROD2">2</a></li></ul></li> <li><a href="/wiki/Neurogenins" title="Neurogenins">Neurogenins</a> <ul><li><a href="/wiki/NEUROG1" class="mw-redirect" title="NEUROG1">1</a></li> <li><a href="/wiki/NEUROG2" class="mw-redirect" title="NEUROG2">2</a></li> <li><a href="/wiki/NEUROG3" class="mw-redirect" title="NEUROG3">3</a></li></ul></li> <li><i>OLIG</i> <ul><li><a href="/wiki/OLIG1" title="OLIG1">1</a></li> <li><a href="/wiki/OLIG2" title="OLIG2">2</a></li></ul></li> <li><i>Paraxis</i> <ul><li><a href="/wiki/TCF15" title="TCF15">TCF15</a></li> <li><a href="/wiki/Scleraxis" title="Scleraxis">Scleraxis</a></li></ul></li> <li><i>SLC</i> <ul><li><a href="/wiki/LYL1" title="LYL1">LYL1</a></li> <li><i>TAL</i> <ul><li><a href="/wiki/TAL1" title="TAL1">1</a></li> <li><a href="/wiki/TAL2" title="TAL2">2</a></li></ul></li></ul></li> <li><a href="/wiki/Twist_transcription_factor" class="mw-redirect" title="Twist transcription factor">Twist</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group B</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/FIGLA" title="FIGLA">FIGLA</a></li> <li><a href="/wiki/Myc" title="Myc">Myc</a> <ul><li><a href="/wiki/MYC" title="MYC">c-Myc</a></li> <li><a href="/wiki/MYCL" title="MYCL">l-Myc</a></li> <li><a href="/wiki/N-Myc" title="N-Myc">n-Myc</a></li></ul></li> <li><a href="/wiki/MXD4" title="MXD4">MXD4</a></li> <li><a href="/wiki/TCF4" title="TCF4">TCF4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group C<br />bHLH-<a href="/wiki/PAS_domain" title="PAS domain">PAS</a></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aryl_hydrocarbon_receptor" title="Aryl hydrocarbon receptor">AhR</a></li> <li><a href="/wiki/Aryl_hydrocarbon_receptor_repressor" title="Aryl hydrocarbon receptor repressor">AHRR</a></li> <li><a href="/wiki/Aryl_hydrocarbon_receptor_nuclear_translocator" title="Aryl hydrocarbon receptor nuclear translocator">ARNT</a> <ul><li><a href="/wiki/ARNTL" class="mw-redirect" title="ARNTL">ARNTL</a></li> <li><a href="/wiki/ARNTL2" title="ARNTL2">ARNTL2</a></li></ul></li> <li><a href="/wiki/CLOCK" title="CLOCK">CLOCK</a></li> <li><a href="/wiki/Hypoxia-inducible_factor" title="Hypoxia-inducible factor">HIF</a> <ul><li><a href="/wiki/HIF1A" title="HIF1A">1A</a></li> <li><a href="/wiki/EPAS1" title="EPAS1">EPAS1</a></li> <li><a href="/wiki/HIF3A" title="HIF3A">3A</a></li></ul></li> <li>NPAS <ul><li><a href="/wiki/NPAS1" title="NPAS1">1</a></li> <li><a href="/wiki/NPAS2" title="NPAS2">2</a></li> <li><a href="/wiki/NPAS3" title="NPAS3">3</a></li></ul></li> <li><i>PER</i> <ul><li><a href="/wiki/PER1" class="mw-redirect" title="PER1">1</a></li> <li><a href="/wiki/PER2" title="PER2">2</a></li> <li><a href="/wiki/PER3" title="PER3">3</a></li> <li><a href="/wiki/Period_(gene)" title="Period (gene)">Period</a></li></ul></li> <li><i>SIM</i> <ul><li><a href="/wiki/SIM1" title="SIM1">1</a></li> <li><a href="/wiki/SIM2" title="SIM2">2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group D</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>BHLH</i> <ul><li><a href="/wiki/BHLHB2" title="BHLHB2">2</a></li> <li><a href="/wiki/BHLHB3" class="mw-redirect" title="BHLHB3">3</a></li> <li><a href="/wiki/BHLHA9" title="BHLHA9">9</a></li></ul></li> <li><a href="/wiki/Pho4" title="Pho4">Pho4</a></li> <li><i>ID</i> <ul><li><a href="/wiki/ID1" title="ID1">1</a></li> <li><a href="/wiki/ID2" title="ID2">2</a></li> <li><a href="/wiki/ID3_(gene)" title="ID3 (gene)">3</a></li> <li><a href="/wiki/ID4" title="ID4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group E</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>HES</i> <ul><li><a href="/wiki/HES1" title="HES1">1</a></li> <li><a href="/wiki/Hes_family_bhlh_transcription_factor_2" title="Hes family bhlh transcription factor 2">2</a></li> <li><a href="/wiki/HES3" title="HES3">3</a></li> <li><a href="/wiki/HES4" title="HES4">4</a></li> <li><a href="/wiki/HES5" title="HES5">5</a></li> <li><a href="/wiki/HES6" title="HES6">6</a></li> <li><a href="/wiki/HES7_gene" title="HES7 gene">7</a></li></ul></li> <li><i>HEY</i> <ul><li><a href="/wiki/HEY1" title="HEY1">1</a></li> <li><a href="/wiki/HEY2" title="HEY2">2</a></li> <li><a href="/wiki/HEYL" title="HEYL">L</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group F<br />bHLH-COE</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/EBF1" title="EBF1">EBF1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.3)</i> <a href="/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors" title="Basic helix-loop-helix leucine zipper transcription factors">bHLH-ZIP</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TFAP4" title="TFAP4">AP-4</a></li> <li><a href="/wiki/MAX_(gene)" title="MAX (gene)">MAX</a> <ul><li><a href="/wiki/MXD1" title="MXD1">MXD1</a></li> <li><a href="/wiki/MXD3" title="MXD3">MXD3</a></li></ul></li> <li><a href="/wiki/Microphthalmia-associated_transcription_factor" title="Microphthalmia-associated transcription factor">MITF</a></li> <li><a href="/wiki/MNT_(gene)" title="MNT (gene)">MNT</a></li> <li><a href="/wiki/MLX_(gene)" title="MLX (gene)">MLX</a></li> <li><a href="/wiki/Carbohydrate-responsive_element-binding_protein" title="Carbohydrate-responsive element-binding protein">MLXIPL</a></li> <li><a href="/wiki/MXI1" title="MXI1">MXI1</a></li> <li><a href="/wiki/Myc" title="Myc">Myc</a></li> <li><a href="/wiki/Sterol_regulatory_element-binding_protein" title="Sterol regulatory element-binding protein">SREBP</a> <ul><li><a href="/wiki/SREBF1" class="mw-redirect" title="SREBF1">1</a></li> <li><a href="/wiki/SREBF2" class="mw-redirect" title="SREBF2">2</a></li></ul></li> <li><a href="/wiki/USF1" title="USF1">USF1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.4) NF-1</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nuclear_factor_I" title="Nuclear factor I">NFI</a> <ul><li><a href="/wiki/NFIA" title="NFIA">A</a></li> <li><a href="/wiki/NFIB_(gene)" title="NFIB (gene)">B</a></li> <li><a href="/wiki/NFIC_(gene)" title="NFIC (gene)">C</a></li> <li><a href="/wiki/NFIX" title="NFIX">X</a></li></ul></li> <li><a href="/wiki/SMAD_(protein)" title="SMAD (protein)">SMAD</a> <ul><li><a href="/wiki/R-SMAD" title="R-SMAD">R-SMAD</a> <ul><li><a href="/wiki/Mothers_against_decapentaplegic_homolog_1" title="Mothers against decapentaplegic homolog 1">1</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_2" title="Mothers against decapentaplegic homolog 2">2</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_3" title="Mothers against decapentaplegic homolog 3">3</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_5" title="Mothers against decapentaplegic homolog 5">5</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_9" title="Mothers against decapentaplegic homolog 9">9</a></li></ul></li> <li><a href="/wiki/I-SMAD" title="I-SMAD">I-SMAD</a> <ul><li><a href="/wiki/Mothers_against_decapentaplegic_homolog_6" title="Mothers against decapentaplegic homolog 6">6</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_7" title="Mothers against decapentaplegic homolog 7">7</a></li></ul></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_4" title="Mothers against decapentaplegic homolog 4">4</a>)</li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.5) RF-X</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><i>RFX</i> <ul><li><a href="/wiki/RFX1" title="RFX1">1</a></li> <li><a href="/wiki/RFX2" title="RFX2">2</a></li> <li><a href="/wiki/RFX3" title="RFX3">3</a></li> <li><a href="/wiki/RFX4" title="RFX4">4</a></li> <li><a href="/wiki/RFX5" title="RFX5">5</a></li> <li><a href="/wiki/RFX6" title="RFX6">6</a></li> <li><a href="/wiki/RFXANK" title="RFXANK">ANK</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.6) Basic helix-span-helix (bHSH)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activating_protein_2" title="Activating protein 2">AP-2</a> <ul><li><a href="/wiki/TFAP2A" title="TFAP2A">α</a></li> <li><a href="/wiki/TFAP2B" title="TFAP2B">β</a></li> <li><a href="/wiki/TFAP2C" title="TFAP2C">γ</a></li> <li><a href="/wiki/TFAP2D" title="TFAP2D">δ</a></li> <li><a href="/wiki/TFAP2E" title="TFAP2E">ε</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(2)_Zinc_finger_DNA-binding_domains" style="font-size:114%;margin:0 4em"><i>(2)</i> <a href="/wiki/Zinc_finger" title="Zinc finger">Zinc finger</a> DNA-binding domains</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.1)</i> <a href="/wiki/Nuclear_receptor" title="Nuclear receptor">Nuclear receptor</a> <i>(Cys<sub>4</sub>)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 1</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Thyroid_hormone_receptor" title="Thyroid hormone receptor">Thyroid hormone</a> <ul><li><a href="/wiki/Thyroid_hormone_receptor_alpha" title="Thyroid hormone receptor alpha">α</a></li> <li><a href="/wiki/Thyroid_hormone_receptor_beta" title="Thyroid hormone receptor beta">β</a></li></ul></li> <li><a href="/wiki/Constitutive_androstane_receptor" title="Constitutive androstane receptor">CAR</a></li> <li><a href="/wiki/Farnesoid_X_receptor" title="Farnesoid X receptor">FXR</a></li> <li><a href="/wiki/Liver_X_receptor" title="Liver X receptor">LXR</a> <ul><li><a href="/wiki/Liver_X_receptor_alpha" title="Liver X receptor alpha">α</a></li> <li><a href="/wiki/Liver_X_receptor_beta" title="Liver X receptor beta">β</a></li></ul></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor" title="Peroxisome proliferator-activated receptor">PPAR</a> <ul><li><a href="/wiki/Peroxisome_proliferator-activated_receptor_alpha" title="Peroxisome proliferator-activated receptor alpha">α</a></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor_delta" title="Peroxisome proliferator-activated receptor delta">β/δ</a></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor_gamma" title="Peroxisome proliferator-activated receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/Pregnane_X_receptor" title="Pregnane X receptor">PXR</a></li> <li><a href="/wiki/Retinoic_acid_receptor" title="Retinoic acid receptor">RAR</a> <ul><li><a href="/wiki/Retinoic_acid_receptor_alpha" title="Retinoic acid receptor alpha">α</a></li> <li><a href="/wiki/Retinoic_acid_receptor_beta" title="Retinoic acid receptor beta">β</a></li> <li><a href="/wiki/Retinoic_acid_receptor_gamma" title="Retinoic acid receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/RAR-related_orphan_receptor" title="RAR-related orphan receptor">ROR</a> <ul><li><a href="/wiki/RAR-related_orphan_receptor_alpha" title="RAR-related orphan receptor alpha">α</a></li> <li><a href="/wiki/RAR-related_orphan_receptor_beta" title="RAR-related orphan receptor beta">β</a></li> <li><a href="/wiki/RAR-related_orphan_receptor_gamma" title="RAR-related orphan receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/Rev-ErbA" class="mw-redirect" title="Rev-ErbA">Rev-ErbA</a> <ul><li><a href="/wiki/Rev-ErbA_alpha" title="Rev-ErbA alpha">α</a></li> <li><a href="/wiki/Rev-ErbA_beta" title="Rev-ErbA beta">β</a></li></ul></li> <li><a href="/wiki/Calcitriol_receptor" class="mw-redirect" title="Calcitriol receptor">VDR</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 2</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chicken_ovalbumin_upstream_promoter-transcription_factor" title="Chicken ovalbumin upstream promoter-transcription factor">COUP-TF</a> <ul><li>(<a href="/wiki/COUP-TFI" title="COUP-TFI">I</a></li> <li><a href="/wiki/COUP-TFII" title="COUP-TFII">II</a></li></ul></li> <li><a href="/wiki/V-erbA-related_gene" title="V-erbA-related gene">Ear-2</a></li> <li><a href="/wiki/Hepatocyte_nuclear_factor_4" title="Hepatocyte nuclear factor 4">HNF4</a> <ul><li><a href="/wiki/Hepatocyte_nuclear_factor_4_alpha" title="Hepatocyte nuclear factor 4 alpha">α</a></li> <li><a href="/wiki/Hepatocyte_nuclear_factor_4_gamma" title="Hepatocyte nuclear factor 4 gamma">γ</a></li></ul></li> <li><a href="/wiki/Photoreceptor_cell-specific_nuclear_receptor" title="Photoreceptor cell-specific nuclear receptor">PNR</a></li> <li><a href="/wiki/Retinoid_X_receptor" title="Retinoid X receptor">RXR</a> <ul><li><a href="/wiki/Retinoid_X_receptor_alpha" title="Retinoid X receptor alpha">α</a></li> <li><a href="/wiki/Retinoid_X_receptor_beta" title="Retinoid X receptor beta">β</a></li> <li><a href="/wiki/Retinoid_X_receptor_gamma" title="Retinoid X receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/Testicular_receptor" title="Testicular receptor">Testicular receptor</a> <ul><li><a href="/wiki/Testicular_receptor_2" title="Testicular receptor 2">2</a></li> <li><a href="/wiki/Testicular_receptor_4" title="Testicular receptor 4">4</a></li></ul></li> <li><a href="/wiki/TLX" title="TLX">TLX</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 3</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Steroid_hormone_receptor" title="Steroid hormone receptor">Steroid hormone</a> <ul><li><a href="/wiki/Androgen_receptor" title="Androgen receptor">Androgen</a></li> <li><a href="/wiki/Estrogen_receptor" title="Estrogen receptor">Estrogen</a> <ul><li><a href="/wiki/Estrogen_receptor_alpha" title="Estrogen receptor alpha">α</a></li> <li><a href="/wiki/Estrogen_receptor_beta" title="Estrogen receptor beta">β</a></li></ul></li> <li><a href="/wiki/Glucocorticoid_receptor" title="Glucocorticoid receptor">Glucocorticoid</a></li> <li><a href="/wiki/Mineralocorticoid_receptor" title="Mineralocorticoid receptor">Mineralocorticoid</a></li> <li><a href="/wiki/Progesterone_receptor" title="Progesterone receptor">Progesterone</a></li></ul></li> <li><a href="/wiki/Estrogen-related_receptor" title="Estrogen-related receptor">Estrogen related</a> <ul><li><a href="/wiki/Estrogen-related_receptor_alpha" title="Estrogen-related receptor alpha">α</a></li> <li><a href="/wiki/Estrogen-related_receptor_beta" title="Estrogen-related receptor beta">β</a></li> <li><a href="/wiki/Estrogen-related_receptor_gamma" title="Estrogen-related receptor gamma">γ</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 4</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nur_(biology)" class="mw-redirect" title="Nur (biology)">NUR</a> <ul><li><a href="/wiki/Nuclear_receptor_4A1" title="Nuclear receptor 4A1">NGFIB</a></li> <li><a href="/wiki/Nuclear_receptor_4A3" title="Nuclear receptor 4A3">NOR1</a></li> <li><a href="/wiki/Nuclear_receptor_4A2" title="Nuclear receptor 4A2">NURR1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 5</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Liver_receptor_homolog-1" title="Liver receptor homolog-1">LRH-1</a></li> <li><a href="/wiki/Steroidogenic_factor_1" title="Steroidogenic factor 1">SF1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 6</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Germ_cell_nuclear_factor" title="Germ cell nuclear factor">GCNF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 0</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/DAX1" title="DAX1">DAX1</a></li> <li><a href="/wiki/Small_heterodimer_partner" title="Small heterodimer partner">SHP</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.2) Other Cys<sub>4</sub></i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/GATA_transcription_factor" title="GATA transcription factor">GATA</a> <ul><li><a href="/wiki/GATA1" title="GATA1">1</a></li> <li><a href="/wiki/GATA2" title="GATA2">2</a></li> <li><a href="/wiki/GATA3" title="GATA3">3</a></li> <li><a href="/wiki/GATA4" title="GATA4">4</a></li> <li><a href="/wiki/GATA5" title="GATA5">5</a></li> <li><a href="/wiki/GATA6" title="GATA6">6</a></li></ul></li> <li><i>MTA</i> <ul><li><a href="/wiki/MTA1" title="MTA1">1</a></li> <li><a href="/wiki/MTA2" title="MTA2">2</a></li> <li><a href="/wiki/MTA3" title="MTA3">3</a></li></ul></li> <li><a href="/wiki/Tricho-rhino-phalangeal_syndrome_Type_1" title="Tricho-rhino-phalangeal syndrome Type 1">TRPS1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.3) Cys<sub>2</sub>His<sub>2</sub></i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/General_transcription_factor" title="General transcription factor">General transcription factors</a> <ul><li><a href="/wiki/Transcription_factor_II_A" title="Transcription factor II A">TFIIA</a></li> <li><a href="/wiki/Transcription_factor_II_B" title="Transcription factor II B">TFIIB</a></li> <li><a href="/wiki/Transcription_factor_II_D" title="Transcription factor II D">TFIID</a></li> <li><a href="/wiki/Transcription_factor_II_E" title="Transcription factor II E">TFIIE</a> <ul><li><a href="/wiki/GTF2E1" title="GTF2E1">1</a></li> <li><a href="/wiki/GTF2E2" title="GTF2E2">2</a></li></ul></li> <li><a href="/wiki/Transcription_factor_II_F" title="Transcription factor II F">TFIIF</a></li> <li><a href="/wiki/GTF2F1" title="GTF2F1">1</a></li> <li><a href="/wiki/GTF2F2" title="GTF2F2">2</a> <ul><li><a href="/wiki/Transcription_factor_II_H" title="Transcription factor II H">TFIIH</a></li> <li><a href="/wiki/GTF2H1" title="GTF2H1">1</a></li> <li><a href="/wiki/GTF2H2" title="GTF2H2">2</a></li> <li><a href="/wiki/GTF2H4" title="GTF2H4">4</a></li> <li><a href="/wiki/GTF2I" title="GTF2I">2I</a></li> <li><a href="/wiki/GTF3A" title="GTF3A">3A</a></li> <li><a href="/wiki/GTF3C1" title="GTF3C1">3C1</a></li> <li><a href="/wiki/GTF3C2" title="GTF3C2">3C2</a></li></ul></li></ul></li></ul> <ul><li><a href="/wiki/ATBF1" title="ATBF1">ATBF1</a></li> <li><i><a href="/wiki/B-cell_CLL/lymphoma" title="B-cell CLL/lymphoma">BCL</a></i> <ul><li><a href="/wiki/BCL6" title="BCL6">6</a></li> <li><a href="/wiki/BCL11A" title="BCL11A">11A</a></li> <li><a href="/wiki/BCL11B" title="BCL11B">11B</a></li></ul></li> <li><a href="/wiki/CTCF" title="CTCF">CTCF</a></li> <li><a href="/wiki/E4F1" title="E4F1">E4F1</a></li> <li><a href="/wiki/Early_growth_response_proteins" title="Early growth response proteins">EGR</a> <ul><li><a href="/wiki/EGR1" title="EGR1">1</a></li> <li><a href="/wiki/EGR2" title="EGR2">2</a></li> <li><a href="/wiki/EGR3" title="EGR3">3</a></li> <li><a href="/wiki/EGR4" title="EGR4">4</a></li></ul></li> <li><a href="/wiki/ERV3" title="ERV3">ERV3</a></li> <li><a href="/wiki/GFI1" title="GFI1">GFI1</a></li> <li><i>GLI family</i> <ul><li><a href="/wiki/GLI1" title="GLI1">1</a></li> <li><a href="/wiki/GLI2" title="GLI2">2</a></li> <li><a href="/wiki/GLI3" title="GLI3">3</a></li> <li><a href="/wiki/RE1-silencing_transcription_factor" title="RE1-silencing transcription factor">REST</a></li> <li><a href="/wiki/GLIS1" title="GLIS1">S1</a></li> <li><a href="/wiki/GLIS2" title="GLIS2">S2</a></li> <li><a href="/wiki/YY1" title="YY1">YY1</a></li></ul></li> <li><i>HIC</i> <ul><li><a href="/wiki/HIC1" title="HIC1">1</a></li> <li><a href="/wiki/HIC2" title="HIC2">2</a></li></ul></li> <li><i>HIVEP</i> <ul><li><a href="/wiki/HIVEP1" title="HIVEP1">1</a></li> <li><a href="/wiki/HIVEP2" title="HIVEP2">2</a></li> <li><a href="/wiki/HIVEP3" title="HIVEP3">3</a></li></ul></li> <li><i>IKZF</i> <ul><li><a href="/wiki/IKZF1" title="IKZF1">1</a></li> <li><a href="/wiki/IKZF2" title="IKZF2">2</a></li> <li><a href="/wiki/IKZF3" title="IKZF3">3</a></li></ul></li> <li><i>ILF</i> <ul><li><a href="/wiki/ILF2" title="ILF2">2</a></li> <li><a href="/wiki/ILF3" title="ILF3">3</a></li></ul></li> <li><a href="/wiki/Kruppel-like_factors" title="Kruppel-like factors">Sp/KLF family</a> <ul><li><i>KLF</i> <ul><li><a href="/wiki/KLF1" title="KLF1">1</a></li> <li><a href="/wiki/KLF2" title="KLF2">2</a></li> <li><a href="/wiki/KLF3" title="KLF3">3</a></li> <li><a href="/wiki/KLF4" title="KLF4">4</a></li> <li><a href="/wiki/KLF5" title="KLF5">5</a></li> <li><a href="/wiki/KLF6" title="KLF6">6</a></li> <li><a href="/wiki/KLF7" title="KLF7">7</a></li> <li><a href="/wiki/KLF8" title="KLF8">8</a></li> <li><a href="/wiki/KLF9" title="KLF9">9</a></li> <li><a href="/wiki/KLF10" title="KLF10">10</a></li> <li><a href="/wiki/KLF11" title="KLF11">11</a></li> <li><a href="/wiki/KLF12" title="KLF12">12</a></li> <li><a href="/wiki/KLF13" title="KLF13">13</a></li> <li><a href="/wiki/KLF14" title="KLF14">14</a></li> <li><a href="/wiki/KLF15" title="KLF15">15</a></li> <li><a href="/wiki/KLF17" title="KLF17">17</a></li></ul></li> <li><i>SP</i> <ul><li><a href="/wiki/Sp1_transcription_factor" class="mw-redirect" title="Sp1 transcription factor">1</a></li> <li><a href="/wiki/SP2_(gene)" class="mw-redirect" title="SP2 (gene)">2</a></li> <li><a href="/wiki/SP4_(gene)" class="mw-redirect" title="SP4 (gene)">4</a></li> <li><a href="/wiki/Sp7_transcription_factor" title="Sp7 transcription factor">7</a></li> <li><a href="/wiki/Sp8_transcription_factor" title="Sp8 transcription factor">8</a></li></ul></li></ul></li> <li><a href="/wiki/MTF1" title="MTF1">MTF1</a></li> <li><a href="/wiki/MYT1" title="MYT1">MYT1</a></li> <li><a href="/wiki/OSR1" title="OSR1">OSR1</a></li> <li><a href="/wiki/PRDM9" title="PRDM9">PRDM9</a></li> <li><i>SALL</i> <ul><li><a href="/wiki/SALL1" title="SALL1">1</a></li> <li><a href="/wiki/SALL2" title="SALL2">2</a></li> <li><a href="/wiki/SALL3" title="SALL3">3</a></li> <li><a href="/wiki/SALL4" title="SALL4">4</a></li></ul></li> <li><a href="/wiki/TSHZ3" title="TSHZ3">TSHZ3</a></li> <li><a href="/wiki/WT1" class="mw-redirect" title="WT1">WT1</a></li> <li><a href="/wiki/Zbtb7" title="Zbtb7">Zbtb7</a> <ul><li><a href="/wiki/ZBTB7A" title="ZBTB7A">7A</a></li> <li><a href="/wiki/ZBTB7B" title="ZBTB7B">7B</a></li></ul></li> <li><i>ZBTB</i> <ul><li><a href="/wiki/ZBTB11" title="ZBTB11">11</a></li> <li><a href="/wiki/Zinc_finger_and_BTB_domain-containing_protein_16" title="Zinc finger and BTB domain-containing protein 16">16</a></li> <li><a href="/wiki/ZBTB17" title="ZBTB17">17</a></li> <li><a href="/wiki/ZBTB20" title="ZBTB20">20</a></li> <li><a href="/wiki/ZBTB21" title="ZBTB21">21</a></li> <li><a href="/wiki/ZBTB32" title="ZBTB32">32</a></li> <li><a href="/wiki/ZBTB33" title="ZBTB33">33</a></li> <li><a href="/wiki/ZBTB40" title="ZBTB40">40</a></li></ul></li> <li><i>zinc finger</i> <ul><li><a href="/wiki/ZNF3" title="ZNF3">3</a></li> <li><a href="/wiki/ZNF7" title="ZNF7">7</a></li> <li><a href="/wiki/CNBP" title="CNBP">9</a></li> <li><a href="/wiki/ZNF10" title="ZNF10">10</a></li> <li><a href="/wiki/ZNF19" title="ZNF19">19</a></li> <li><a href="/wiki/ZNF22" title="ZNF22">22</a></li> <li><a href="/wiki/ZNF24" title="ZNF24">24</a></li> <li><a href="/wiki/ZNF33B" title="ZNF33B">33B</a></li> <li><a href="/wiki/ZNF34" title="ZNF34">34</a></li> <li><a href="/wiki/ZNF35" title="ZNF35">35</a></li> <li><a href="/wiki/ZNF41" title="ZNF41">41</a></li> <li><a href="/wiki/ZNF43" title="ZNF43">43</a></li> <li><a href="/wiki/ZNF44" title="ZNF44">44</a></li> <li><a href="/wiki/BCL6" title="BCL6">51</a></li> <li><a href="/wiki/ZNF74" title="ZNF74">74</a></li> <li><a href="/wiki/ZNF143" title="ZNF143">143</a></li> <li><a href="/wiki/ZNF146" title="ZNF146">146</a></li> <li><a href="/wiki/ZNF148" title="ZNF148">148</a></li> <li><a href="/wiki/Zinc_finger_protein_165" title="Zinc finger protein 165">165</a></li> <li><a href="/wiki/ZNF202" title="ZNF202">202</a></li> <li><a href="/wiki/ZNF217" title="ZNF217">217</a></li> <li><a href="/wiki/ZNF219" title="ZNF219">219</a></li> <li><a href="/wiki/ZNF238" title="ZNF238">238</a></li> <li><a href="/wiki/ZNF239" title="ZNF239">239</a></li> <li><a href="/wiki/ZNF259" title="ZNF259">259</a></li> <li><a href="/wiki/ZNF267" title="ZNF267">267</a></li> <li><a href="/wiki/EGR1" title="EGR1">268</a></li> <li><a href="/wiki/ZNF281" title="ZNF281">281</a></li> <li><a href="/wiki/ZNF300" title="ZNF300">300</a></li> <li><a href="/wiki/ZNF318" title="ZNF318">318</a></li> <li><a href="/wiki/ZNF330" title="ZNF330">330</a></li> <li><a href="/wiki/ZNF346" title="ZNF346">346</a></li> <li><a href="/wiki/ZNF350" title="ZNF350">350</a></li> <li><a href="/wiki/ZNF365" title="ZNF365">365</a></li> <li><a href="/wiki/ZNF366" title="ZNF366">366</a></li> <li><a href="/wiki/ZNF384" title="ZNF384">384</a></li> <li><a href="/wiki/ZNF423" title="ZNF423">423</a></li> <li><a href="/wiki/ZNF451" title="ZNF451">451</a></li> <li><a href="/wiki/ZNF452" title="ZNF452">452</a></li> <li><a href="/wiki/ZNF471" title="ZNF471">471</a></li> <li><a href="/wiki/ZNF593" title="ZNF593">593</a></li> <li><a href="/wiki/ZNF638" title="ZNF638">638</a></li> <li><a href="/wiki/ZNF644" title="ZNF644">644</a></li> <li><a href="/wiki/ZNF649" title="ZNF649">649</a></li> <li><a href="/wiki/ZNF655" title="ZNF655">655</a></li> <li><a href="/wiki/ZNF804A" class="mw-redirect" title="ZNF804A">804A</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.4) Cys<sub>6</sub></i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HIVEP1" title="HIVEP1">HIVEP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.5) Alternating composition</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Autoimmune_regulator" title="Autoimmune regulator">AIRE</a></li> <li><a href="/wiki/DIDO1" title="DIDO1">DIDO1</a></li> <li><a href="/wiki/GRLF1" title="GRLF1">GRLF1</a></li> <li><i>ING</i> <ul><li><a href="/wiki/ING1" title="ING1">1</a></li> <li><a href="/wiki/ING2" title="ING2">2</a></li> <li><a href="/wiki/ING4" title="ING4">4</a></li></ul></li> <li><i>JARID</i> <ul><li><a href="/wiki/KDM5A" title="KDM5A">1A</a></li> <li><a href="/wiki/KDM5B" class="mw-redirect" title="KDM5B">1B</a></li> <li><a href="/wiki/KDM5C" title="KDM5C">1C</a></li> <li><a href="/wiki/KDM5D" title="KDM5D">1D</a></li> <li><a href="/wiki/JARID2" title="JARID2">2</a></li></ul></li> <li><a href="/wiki/KDM3B" title="KDM3B">JMJD1B</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.6) WRKY</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/WRKY_protein_domain" title="WRKY protein domain">WRKY</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(3)_Helix-turn-helix_domains" style="font-size:114%;margin:0 4em"><i>(3)</i> <a href="/wiki/Helix-turn-helix" title="Helix-turn-helix">Helix-turn-helix</a> <i>domains</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.1)</i> <a href="/wiki/Homeodomain_fold" class="mw-redirect" title="Homeodomain fold">Homeodomain</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i><a href="/wiki/Antennapedia" title="Antennapedia">Antennapedia</a></i></span><br /><span class="nobold"><i>ANTP class</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>protoHOX</i></span><br /><span class="nobold"><i>Hox-like</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ParaHox" title="ParaHox">ParaHox</a> <ul><li><a href="/wiki/Gsx_(gene_family)" title="Gsx (gene family)">Gsx</a> <ul><li><a href="/wiki/GSX1" title="GSX1">1</a></li> <li><a href="/wiki/GSX2" title="GSX2">2</a></li></ul></li> <li><a href="/wiki/Xlox" class="mw-redirect" title="Xlox">Xlox</a> <ul><li><a href="/wiki/PDX1" title="PDX1">PDX1</a></li></ul></li> <li><a href="/wiki/Cdx" title="Cdx">Cdx</a> <ul><li><a href="/wiki/CDX1" class="mw-redirect" title="CDX1">1</a></li> <li><a href="/wiki/CDX2" class="mw-redirect" title="CDX2">2</a></li> <li><a href="/wiki/CDX4_(gene)" class="mw-redirect" title="CDX4 (gene)">4</a></li></ul></li></ul></li> <li>extended Hox: <a href="/wiki/Evx1" title="Evx1">Evx1</a></li> <li><a href="/w/index.php?title=Evx2&action=edit&redlink=1" class="new" title="Evx2 (page does not exist)">Evx2</a></li> <li><a href="/wiki/MEOX1" title="MEOX1">MEOX1</a></li> <li><a href="/wiki/MEOX2" title="MEOX2">MEOX2</a></li> <li><a href="/wiki/Homeobox" title="Homeobox">Homeobox</a> <ul><li><a href="/wiki/Homeobox_A1" title="Homeobox A1">A1</a></li> <li><a href="/wiki/HOXA2" title="HOXA2">A2</a></li> <li><a href="/wiki/HOXA3" title="HOXA3">A3</a></li> <li><a href="/wiki/HOXA4" title="HOXA4">A4</a></li> <li><a href="/wiki/HOXA5" title="HOXA5">A5</a></li> <li><a href="/wiki/HOXA7" title="HOXA7">A7</a></li> <li><a href="/wiki/HOXA9" title="HOXA9">A9</a></li> <li><a href="/wiki/Homeobox_A10" title="Homeobox A10">A10</a></li> <li><a href="/wiki/HOXA11" title="HOXA11">A11</a></li> <li><a href="/wiki/HOXA13" title="HOXA13">A13</a></li> <li><a href="/wiki/HOXB1" title="HOXB1">B1</a></li> <li><a href="/wiki/HOXB2" title="HOXB2">B2</a></li> <li><a href="/wiki/HOXB3" title="HOXB3">B3</a></li> <li><a href="/wiki/HOXB4" title="HOXB4">B4</a></li> <li><a href="/wiki/HOXB5" title="HOXB5">B5</a></li> <li><a href="/wiki/HOXB6" title="HOXB6">B6</a></li> <li><a href="/wiki/HOXB7" title="HOXB7">B7</a></li> <li><a href="/wiki/HOXB8" title="HOXB8">B8</a></li> <li><a href="/wiki/HOXB9" title="HOXB9">B9</a></li> <li><a href="/wiki/HOXB13" title="HOXB13">B13</a></li> <li><a href="/wiki/HOXC4" title="HOXC4">C4</a></li> <li><a href="/wiki/HOXC5" title="HOXC5">C5</a></li> <li><a href="/wiki/HOXC6" title="HOXC6">C6</a></li> <li><a href="/wiki/HOXC8" title="HOXC8">C8</a></li> <li><a href="/wiki/HOXC9" title="HOXC9">C9</a></li> <li><a href="/wiki/HOXC10" title="HOXC10">C10</a></li> <li><a href="/wiki/HOXC11" title="HOXC11">C11</a></li> <li><a href="/wiki/HOXC12" title="HOXC12">C12</a></li> <li><a href="/wiki/HOXC13" title="HOXC13">C13</a></li> <li><a href="/wiki/HOXD1" title="HOXD1">D1</a></li> <li><a href="/wiki/HOXD3" title="HOXD3">D3</a></li> <li><a href="/wiki/HOXD4" title="HOXD4">D4</a></li> <li><a href="/wiki/HOXD8" title="HOXD8">D8</a></li> <li><a href="/wiki/HOXD9" title="HOXD9">D9</a></li> <li><a href="/wiki/HOXD10" title="HOXD10">D10</a></li> <li><a href="/wiki/HOXD11" title="HOXD11">D11</a></li> <li><a href="/wiki/HOXD12" title="HOXD12">D12</a></li> <li><a href="/wiki/HOXD13" title="HOXD13">D13</a></li></ul></li> <li><a href="/w/index.php?title=GBX1&action=edit&redlink=1" class="new" title="GBX1 (page does not exist)">GBX1</a></li> <li><a href="/wiki/GBX2" title="GBX2">GBX2</a></li> <li><a href="/wiki/MNX1" title="MNX1">MNX1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>metaHOX</i></span><br /><span class="nobold"><i>NK-like</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=BARHL1&action=edit&redlink=1" class="new" title="BARHL1 (page does not exist)">BARHL1</a></li> <li><a href="/wiki/BARHL2" title="BARHL2">BARHL2</a></li> <li><a href="/w/index.php?title=BARX1&action=edit&redlink=1" class="new" title="BARX1 (page does not exist)">BARX1</a></li> <li><a href="/w/index.php?title=BARX2&action=edit&redlink=1" class="new" title="BARX2 (page does not exist)">BARX2</a></li> <li><a href="/wiki/Brain-specific_homeobox" title="Brain-specific homeobox">BSX</a></li> <li><i>DBX</i> <ul><li><a href="/wiki/DBX1" title="DBX1">1</a></li> <li><a href="/wiki/DBX2" title="DBX2">2</a></li></ul></li> <li><a href="/wiki/DLX_gene_family" title="DLX gene family">DLX</a> <ul><li><a href="/wiki/DLX1" title="DLX1">1</a></li> <li><a href="/wiki/DLX2" title="DLX2">2</a></li> <li><a href="/wiki/DLX3_(gene)" class="mw-redirect" title="DLX3 (gene)">3</a></li> <li><a href="/wiki/DLX4" title="DLX4">4</a></li> <li><a href="/wiki/DLX5" title="DLX5">5</a></li> <li><a href="/wiki/DLX6" title="DLX6">6</a></li></ul></li> <li><i><a href="/wiki/EMX_homeogene" title="EMX homeogene">EMX</a></i> <ul><li><a href="/wiki/EMX1" title="EMX1">1</a></li> <li><a href="/wiki/EMX2" title="EMX2">2</a></li></ul></li> <li><i>EN</i> <ul><li><a href="/wiki/EN1_(gene)" title="EN1 (gene)">1</a></li> <li><a href="/wiki/EN2_(gene)" title="EN2 (gene)">2</a></li></ul></li> <li><a href="/wiki/HHEX" title="HHEX">HHEX</a></li> <li><a href="/wiki/HLX_(gene)" title="HLX (gene)">HLX</a></li> <li><a href="/wiki/LBX1" title="LBX1">LBX1</a></li> <li><a href="/wiki/LBX2" title="LBX2">LBX2</a></li> <li><i>MSX</i> <ul><li><a href="/wiki/MSX1" class="mw-redirect" title="MSX1">1</a></li> <li><a href="/wiki/Msh_homeobox_2" title="Msh homeobox 2">2</a></li></ul></li> <li><a href="/wiki/Homeobox_protein_NANOG" title="Homeobox protein NANOG">NANOG</a></li> <li><a href="/wiki/NKX-homeodomain_factor" title="NKX-homeodomain factor">NKX</a> <ul><li><a href="/wiki/NK2_homeobox_1" title="NK2 homeobox 1">2-1</a></li> <li><a href="/wiki/NKX2-2" title="NKX2-2">2-2</a></li> <li><a href="/wiki/NKX2-3" title="NKX2-3">2-3</a></li> <li><a href="/wiki/Homeobox_protein_Nkx-2.5" title="Homeobox protein Nkx-2.5">2-5</a></li> <li><a href="/wiki/NKX3-1" title="NKX3-1">3-1</a></li> <li><a href="/wiki/NKX3-2" title="NKX3-2">3-2</a></li> <li><a href="/w/index.php?title=HMX1&action=edit&redlink=1" class="new" title="HMX1 (page does not exist)">HMX1</a></li> <li><a href="/w/index.php?title=HMX2&action=edit&redlink=1" class="new" title="HMX2 (page does not exist)">HMX2</a></li> <li><a href="/w/index.php?title=HMX3&action=edit&redlink=1" class="new" title="HMX3 (page does not exist)">HMX3</a></li> <li><a href="/wiki/NKX6-1" title="NKX6-1">6-1</a></li> <li><a href="/wiki/NKX6-2" title="NKX6-2">6-2</a></li></ul></li> <li><a href="/wiki/NATO" title="NATO">NATO</a></li> <li><a href="/wiki/TLX1" title="TLX1">TLX1</a></li> <li><a href="/wiki/TLX2" title="TLX2">TLX2</a></li> <li><a href="/wiki/TLX3" title="TLX3">TLX3</a></li> <li><a href="/wiki/VAX1" title="VAX1">VAX1</a></li> <li><a href="/w/index.php?title=VAX2&action=edit&redlink=1" class="new" title="VAX2 (page does not exist)">VAX2</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">other</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aristaless_related_homeobox" title="Aristaless related homeobox">ARX</a></li> <li><a href="/wiki/CRX_(gene)" title="CRX (gene)">CRX</a></li> <li><a href="/wiki/CUTL1" title="CUTL1">CUTL1</a></li> <li><i>FHL</i> <ul><li><a href="/wiki/FHL1" title="FHL1">1</a></li> <li><a href="/wiki/FHL2" title="FHL2">2</a></li> <li><a href="/wiki/FHL3" title="FHL3">3</a></li></ul></li> <li><a href="/wiki/HESX1" title="HESX1">HESX1</a></li> <li><a href="/wiki/HOPX" title="HOPX">HOPX</a></li> <li><i>LMX</i> <ul><li><a href="/wiki/LMX1A" title="LMX1A">1A</a></li> <li><a href="/wiki/LMX1B" title="LMX1B">1B</a></li></ul></li> <li><a href="/wiki/NOBOX" title="NOBOX">NOBOX</a></li> <li>TALE <ul><li><a href="/wiki/Iroquois_homeobox_factor" title="Iroquois homeobox factor">IRX</a> <ul><li><a href="/wiki/IRX1" title="IRX1">1</a></li> <li><a href="/wiki/IRX2" title="IRX2">2</a></li> <li><a href="/wiki/IRX3" title="IRX3">3</a></li> <li><a href="/wiki/IRX4" title="IRX4">4</a></li> <li><a href="/wiki/IRX5" title="IRX5">5</a></li> <li><a href="/wiki/IRX6" title="IRX6">6</a></li> <li><a href="/wiki/MKX" title="MKX">MKX</a></li></ul></li> <li><i>MEIS</i> <ul><li><a href="/wiki/MEIS1" title="MEIS1">1</a></li> <li><a href="/wiki/MEIS2" title="MEIS2">2</a></li></ul></li> <li><i>PBX</i> <ul><li><a href="/wiki/PBX1" title="PBX1">1</a></li> <li><a href="/wiki/PBX2" title="PBX2">2</a></li> <li><a href="/wiki/PBX3" title="PBX3">3</a></li></ul></li> <li><i>PKNOX</i> <ul><li><a href="/wiki/PKNOX1" title="PKNOX1">1</a></li> <li><a href="/wiki/PKNOX2" title="PKNOX2">2</a></li></ul></li> <li><i>SIX</i> <ul><li><a href="/wiki/SIX1" class="mw-redirect" title="SIX1">1</a></li> <li><a href="/wiki/SIX2" title="SIX2">2</a></li> <li><a href="/wiki/SIX3" title="SIX3">3</a></li> <li><a href="/wiki/SIX4" title="SIX4">4</a></li> <li><a href="/wiki/SIX5" title="SIX5">5</a></li></ul></li></ul></li> <li><i>PHF</i> <ul><li><a href="/wiki/PHF1" title="PHF1">1</a></li> <li><a href="/wiki/PHF3" title="PHF3">3</a></li> <li><a href="/wiki/PHF6" title="PHF6">6</a></li> <li><a href="/wiki/PHF8" title="PHF8">8</a></li> <li><a href="/wiki/PHF10" title="PHF10">10</a></li> <li><a href="/wiki/PHF16" title="PHF16">16</a></li> <li><a href="/wiki/PHF17" class="mw-redirect" title="PHF17">17</a></li> <li><a href="/wiki/PHF20" title="PHF20">20</a></li> <li><a href="/wiki/PHF21A" title="PHF21A">21A</a></li></ul></li> <li><a href="/wiki/POU_domain" title="POU domain">POU domain</a> <ul><li><a href="/wiki/Pituitary-specific_positive_transcription_factor_1" title="Pituitary-specific positive transcription factor 1">PIT-1</a></li> <li><a href="/wiki/BRN-3" title="BRN-3">BRN-3</a>: <a href="/wiki/POU4F1" title="POU4F1">A</a></li> <li><a href="/wiki/POU4F2" title="POU4F2">B</a></li> <li><a href="/wiki/POU4F3" title="POU4F3">C</a></li> <li><a href="/wiki/Octamer_transcription_factor" title="Octamer transcription factor">Octamer transcription factor</a>: <a href="/wiki/POU2F1" title="POU2F1">1</a></li> <li><a href="/wiki/Oct-2" title="Oct-2">2</a></li> <li><a href="/wiki/Oct-4" title="Oct-4">3/4</a></li> <li><a href="/wiki/POU3F1" title="POU3F1">6</a></li> <li><a href="/wiki/POU3F2" title="POU3F2">7</a></li> <li><a href="/wiki/POU3F4" title="POU3F4">11</a></li></ul></li> <li><a href="/wiki/SATB2" title="SATB2">SATB2</a></li> <li><i>ZEB</i> <ul><li><a href="/wiki/ZEB1" title="ZEB1">1</a></li> <li><a href="/wiki/ZEB2" title="ZEB2">2</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.2) Paired box</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pax_genes" title="Pax genes">PAX</a> <ul><li><a href="/wiki/PAX1" title="PAX1">1</a></li> <li><a href="/wiki/PAX2" title="PAX2">2</a></li> <li><a href="/wiki/PAX3" title="PAX3">3</a></li> <li><a href="/wiki/PAX4" title="PAX4">4</a></li> <li><a href="/wiki/PAX5" title="PAX5">5</a></li> <li><a href="/wiki/PAX6" title="PAX6">6</a></li> <li><a href="/wiki/PAX7" title="PAX7">7</a></li> <li><a href="/wiki/PAX8" title="PAX8">8</a></li> <li><a href="/wiki/PAX9" title="PAX9">9</a></li></ul></li> <li>PRRX <ul><li><a href="/wiki/PRRX1" title="PRRX1">1</a></li> <li><a href="/wiki/PRRX2" title="PRRX2">2</a></li></ul></li> <li><a href="/wiki/PROP1" title="PROP1">PROP1</a></li> <li><i>PHOX</i> <ul><li><a href="/wiki/PHOX2A" title="PHOX2A">2A</a></li> <li><a href="/wiki/PHOX2B" title="PHOX2B">2B</a></li></ul></li> <li><a href="/wiki/Retinal_homeobox_protein_Rx" title="Retinal homeobox protein Rx">RAX</a></li> <li><a href="/wiki/Short-stature_homeobox_gene" title="Short-stature homeobox gene">SHOX</a></li> <li><a href="/wiki/SHOX2" title="SHOX2">SHOX2</a></li> <li><a href="/wiki/VSX1" title="VSX1">VSX1</a></li> <li><a href="/wiki/VSX2" title="VSX2">VSX2</a></li> <li><a href="/wiki/Bicoid_(gene)" class="mw-redirect" title="Bicoid (gene)">Bicoid</a> <ul><li><a href="/wiki/Goosecoid_protein" class="mw-redirect" title="Goosecoid protein">GSC</a></li> <li><a href="/wiki/BICD2" title="BICD2">BICD2</a></li> <li><i>OTX</i> <ul><li><a href="/wiki/OTX1" title="OTX1">1</a></li> <li><a href="/wiki/Orthodenticle_homeobox_2" title="Orthodenticle homeobox 2">2</a></li></ul></li> <li><i>PITX</i> <ul><li><a href="/wiki/PITX1" title="PITX1">1</a></li> <li><a href="/wiki/PITX2" title="PITX2">2</a></li> <li><a href="/wiki/PITX3" title="PITX3">3</a></li></ul></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.3)</i> <a href="/wiki/FOX_proteins" title="FOX proteins">Fork head</a> / <a href="/wiki/Winged-helix_transcription_factors" title="Winged-helix transcription factors">winged helix</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/E2F" title="E2F">E2F</a> <ul><li><a href="/wiki/E2F1" title="E2F1">1</a></li> <li><a href="/wiki/E2F2" title="E2F2">2</a></li> <li><a href="/wiki/E2F3" title="E2F3">3</a></li> <li><a href="/wiki/E2F4" title="E2F4">4</a></li> <li><a href="/wiki/E2F5" title="E2F5">5</a></li></ul></li> <li><a href="/wiki/FOX_proteins" title="FOX proteins">FOX proteins</a> <ul><li><a href="/wiki/FOXA1" title="FOXA1">A1</a></li> <li><a href="/wiki/FOXA2" title="FOXA2">A2</a></li> <li><a href="/wiki/FOXA3" title="FOXA3">A3</a></li> <li><a href="/wiki/FOXB1" class="mw-redirect" title="FOXB1">B1</a></li> <li><a href="/w/index.php?title=FOXB2&action=edit&redlink=1" class="new" title="FOXB2 (page does not exist)">B2</a></li> <li><a href="/wiki/Forkhead_box_C1" title="Forkhead box C1">C1</a></li> <li><a href="/wiki/FOXC2" title="FOXC2">C2</a></li> <li><a href="/wiki/FOXD1" class="mw-redirect" title="FOXD1">D1</a></li> <li><a href="/w/index.php?title=FOXD2&action=edit&redlink=1" class="new" title="FOXD2 (page does not exist)">D2</a></li> <li><a href="/wiki/FOXD3" title="FOXD3">D3</a></li> <li><a href="/wiki/FOXD4" title="FOXD4">D4</a></li> <li><a href="/w/index.php?title=FOXD4L1&action=edit&redlink=1" class="new" title="FOXD4L1 (page does not exist)">D4L1</a></li> <li><a href="/w/index.php?title=FOXD4L3&action=edit&redlink=1" class="new" title="FOXD4L3 (page does not exist)">D4L3</a></li> <li><a href="/w/index.php?title=FOXD4L4&action=edit&redlink=1" class="new" title="FOXD4L4 (page does not exist)">D4L4</a></li> <li><a href="/w/index.php?title=FOXD4L5&action=edit&redlink=1" class="new" title="FOXD4L5 (page does not exist)">D4L5</a></li> <li><a href="/w/index.php?title=FOXD4L6&action=edit&redlink=1" class="new" title="FOXD4L6 (page does not exist)">D4L6</a></li> <li><a href="/wiki/FOXE1" title="FOXE1">E1</a></li> <li><a href="/wiki/FOXE3" title="FOXE3">E3</a></li> <li><a href="/wiki/FOXF1" title="FOXF1">F1</a></li> <li><a href="/wiki/FOXF2" title="FOXF2">F2</a></li> <li><a href="/wiki/FOXG1" title="FOXG1">G1</a></li> <li><a href="/wiki/FOXH1" title="FOXH1">H1</a></li> <li><a href="/wiki/FOXI1" title="FOXI1">I1</a></li> <li><a href="/w/index.php?title=FOXI2&action=edit&redlink=1" class="new" title="FOXI2 (page does not exist)">I2</a></li> <li><a href="/wiki/FOXI3" title="FOXI3">I3</a></li> <li><a href="/wiki/FOXJ1" title="FOXJ1">J1</a></li> <li><a href="/wiki/FOXJ2" title="FOXJ2">J2</a></li> <li><a href="/w/index.php?title=FOXJ3&action=edit&redlink=1" class="new" title="FOXJ3 (page does not exist)">J3</a></li> <li><a href="/wiki/FOXK1" title="FOXK1">K1</a></li> <li><a href="/wiki/FOXK2" title="FOXK2">K2</a></li> <li><a href="/w/index.php?title=FOXL1&action=edit&redlink=1" class="new" title="FOXL1 (page does not exist)">L1</a></li> <li><a href="/wiki/Forkhead_box_L2" class="mw-redirect" title="Forkhead box L2">L2</a></li> <li><a href="/wiki/FOXM1" title="FOXM1">M1</a></li> <li><a href="/wiki/FOXN1" title="FOXN1">N1</a></li> <li><a href="/w/index.php?title=FOXN2&action=edit&redlink=1" class="new" title="FOXN2 (page does not exist)">N2</a></li> <li><a href="/wiki/FOXN3" title="FOXN3">N3</a></li> <li><a href="/w/index.php?title=FOXN4&action=edit&redlink=1" class="new" title="FOXN4 (page does not exist)">N4</a></li> <li><a href="/wiki/FOXO1" class="mw-redirect" title="FOXO1">O1</a></li> <li><a href="/wiki/FOXO3" title="FOXO3">O3</a></li> <li><a href="/wiki/FOXO4" title="FOXO4">O4</a></li> <li><a href="/wiki/FOXO6" title="FOXO6">O6</a></li> <li><a href="/wiki/FOXP1" title="FOXP1">P1</a></li> <li><a href="/wiki/FOXP2" title="FOXP2">P2</a></li> <li><a href="/wiki/FOXP3" title="FOXP3">P3</a></li> <li><a href="/wiki/FOXP4" title="FOXP4">P4</a></li> <li><a href="/wiki/FOXQ1" title="FOXQ1">Q1</a></li> <li><a href="/w/index.php?title=FOXR1&action=edit&redlink=1" class="new" title="FOXR1 (page does not exist)">R1</a></li> <li><a href="/w/index.php?title=FOXR2&action=edit&redlink=1" class="new" title="FOXR2 (page does not exist)">R2</a></li> <li><a href="/wiki/FOXS1" title="FOXS1">S1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.4)</i> <a href="/wiki/Heat_shock_factor" title="Heat shock factor">Heat shock factors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Heat_shock_factor" title="Heat shock factor">HSF</a></i> <ul><li><a href="/wiki/HSF1" class="mw-redirect" title="HSF1">1</a></li> <li><a href="/wiki/HSF2" title="HSF2">2</a></li> <li><a href="/wiki/HSF4" title="HSF4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.5) Tryptophan clusters</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><i>ELF</i> <ul><li><a href="/wiki/ELF2" title="ELF2">2</a></li> <li><a href="/wiki/ELF4" title="ELF4">4</a></li> <li><a href="/wiki/ELF5" title="ELF5">5</a></li></ul></li> <li><a href="/wiki/EHF_(gene)" title="EHF (gene)">EGF</a></li> <li><i>ELK</i> <ul><li><a href="/wiki/ELK1" title="ELK1">1</a></li> <li><a href="/wiki/ELK3" title="ELK3">3</a></li> <li><a href="/wiki/ELK4" title="ELK4">4</a></li></ul></li> <li><a href="/wiki/ERF_(gene)" title="ERF (gene)">ERF</a></li> <li><a href="/wiki/ETS_transcription_factor_family" title="ETS transcription factor family">ETS</a> <ul><li><a href="/wiki/ETS1" title="ETS1">1</a></li> <li><a href="/wiki/ETS2" title="ETS2">2</a></li> <li><a href="/wiki/ERG_(gene)" title="ERG (gene)">ERG</a></li> <li><a href="/wiki/SPIB" title="SPIB">SPIB</a></li></ul></li> <li><i>ETV</i> <ul><li><a href="/wiki/ETV1" title="ETV1">1</a></li> <li><a href="/wiki/ETV4" title="ETV4">4</a></li> <li><a href="/wiki/ERM_transcription_factor" class="mw-redirect" title="ERM transcription factor">5</a></li> <li><a href="/wiki/ETV6" title="ETV6">6</a></li></ul></li> <li><a href="/wiki/FLI1" title="FLI1">FLI1</a></li> <li><a href="/wiki/Interferon_regulatory_factors" title="Interferon regulatory factors">Interferon regulatory factors</a> <ul><li><a href="/wiki/IRF1" title="IRF1">1</a></li> <li><a href="/wiki/IRF2" title="IRF2">2</a></li> <li><a href="/wiki/IRF3" title="IRF3">3</a></li> <li><a href="/wiki/IRF4" title="IRF4">4</a></li> <li><a href="/wiki/IRF5" title="IRF5">5</a></li> <li><a href="/wiki/IRF6" title="IRF6">6</a></li> <li><a href="/wiki/IRF7" title="IRF7">7</a></li> <li><a href="/wiki/IRF8" title="IRF8">8</a></li></ul></li> <li><a href="/wiki/MYB_(gene)" title="MYB (gene)">MYB</a></li> <li><a href="/wiki/MYBL2" title="MYBL2">MYBL2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.6) TEA domain</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>transcriptional enhancer factor</i> <ul><li><a href="/wiki/TEAD1" title="TEAD1">1</a></li> <li><a href="/wiki/TEAD2" title="TEAD2">2</a></li> <li><a href="/wiki/TEAD3" title="TEAD3">3</a></li> <li><a href="/wiki/TEAD4" title="TEAD4">4</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible uncollapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(4)_β-Scaffold_factors_with_minor_groove_contacts" style="font-size:114%;margin:0 4em">(4) <i>β-Scaffold factors with minor groove contacts</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.1)</i> <a href="/wiki/Rel_homology_domain" title="Rel homology domain">Rel homology region</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/NF-%CE%BAB" title="NF-κB">NF-κB</a> <ul><li><a href="/wiki/NFKB1" title="NFKB1">NFKB1</a></li> <li><a href="/wiki/NFKB2" title="NFKB2">NFKB2</a></li> <li><a href="/wiki/REL" title="REL">REL</a></li> <li><a href="/wiki/RELA" title="RELA">RELA</a></li> <li><a href="/wiki/RELB" title="RELB">RELB</a></li></ul></li> <li><a href="/wiki/NFAT" title="NFAT">NFAT</a> <ul><li><a href="/wiki/NFATC1" title="NFATC1">C1</a></li> <li><a href="/wiki/NFATC2" title="NFATC2">C2</a></li> <li><a href="/wiki/NFATC3" title="NFATC3">C3</a></li> <li><a href="/wiki/NFATC4" title="NFATC4">C4</a></li> <li><a href="/wiki/NFAT5" title="NFAT5">5</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.2)</i> <a href="/wiki/STAT_protein" title="STAT protein">STAT</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/STAT_protein" title="STAT protein">STAT</a> <ul><li><a class="mw-selflink selflink">1</a></li> <li><a href="/wiki/STAT2" title="STAT2">2</a></li> <li><a href="/wiki/STAT3" title="STAT3">3</a></li> <li><a href="/wiki/STAT4" title="STAT4">4</a></li> <li><a href="/wiki/STAT5" title="STAT5">5</a></li> <li><a href="/wiki/STAT6" title="STAT6">6</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.3) p53-like</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/P53_p63_p73_family" title="P53 p63 p73 family">p53 p63 p73 family</a> <ul><li><a href="/wiki/P53" title="P53">p53</a></li> <li><a href="/wiki/TP63" title="TP63">TP63</a></li> <li><a href="/wiki/P73" title="P73">p73</a></li></ul></li> <li><a href="/wiki/T-box" title="T-box">TBX</a> <ul><li><a href="/wiki/TBX1" title="TBX1">1</a></li> <li><a href="/wiki/TBX2" title="TBX2">2</a></li> <li><a href="/wiki/TBX3" title="TBX3">3</a></li> <li><a href="/wiki/TBX5_(gene)" title="TBX5 (gene)">5</a></li> <li><a href="/wiki/TBX19" title="TBX19">19</a></li> <li><a href="/wiki/TBX21" title="TBX21">21</a></li> <li><a href="/wiki/TBX22" title="TBX22">22</a></li> <li><a href="/wiki/TBR1" title="TBR1">TBR1</a></li> <li><a href="/wiki/Eomesodermin" title="Eomesodermin">TBR2</a></li> <li><a href="/wiki/Brachyury" class="mw-redirect" title="Brachyury">TFT</a></li></ul></li> <li><a href="/wiki/Myelin_regulatory_factor" title="Myelin regulatory factor">MYRF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.4)</i> <a href="/wiki/MADS-box" title="MADS-box">MADS box</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mef2" title="Mef2">Mef2</a> <ul><li><a href="/wiki/Myocyte-specific_enhancer_factor_2A" title="Myocyte-specific enhancer factor 2A">A</a></li> <li><a href="/wiki/MEF2B" title="MEF2B">B</a></li> <li><a href="/wiki/MEF2C" title="MEF2C">C</a></li> <li><a href="/wiki/MEF2D" title="MEF2D">D</a></li></ul></li> <li><a href="/wiki/Serum_response_factor" title="Serum response factor">SRF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.6)</i> <a href="/wiki/TATA-binding_protein" title="TATA-binding protein">TATA-binding proteins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TATA-binding_protein" title="TATA-binding protein">TBP</a></li> <li><a href="/wiki/TBPL1" title="TBPL1">TBPL1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.7)</i> <a href="/wiki/High-mobility_group" title="High-mobility group">High-mobility group</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/BBX_(gene)" title="BBX (gene)">BBX</a></li> <li><a href="/wiki/HMG-box" title="HMG-box">HMGB</a> <ul><li><a href="/wiki/HMGB1" title="HMGB1">1</a></li> <li><a href="/wiki/HMGB2" title="HMGB2">2</a></li> <li><a href="/wiki/HMGB3" title="HMGB3">3</a></li> <li><a href="/wiki/HMGB4" title="HMGB4">4</a></li></ul></li> <li><a href="/wiki/HMGN" title="HMGN">HMGN</a> <ul><li><a href="/wiki/HMGN1" title="HMGN1">1</a></li> <li><a href="/wiki/HMGN2" title="HMGN2">2</a></li> <li><a href="/wiki/HMGN3" title="HMGN3">3</a></li> <li><a href="/wiki/HMGN4" title="HMGN4">4</a></li></ul></li> <li><i>HNF</i> <ul><li><a href="/wiki/HNF1A" title="HNF1A">1A</a></li> <li><a href="/wiki/HNF1B" title="HNF1B">1B</a></li></ul></li> <li><a href="/wiki/SOX_gene_family" title="SOX gene family">SOX</a> <ul><li><a href="/wiki/SOX1" title="SOX1">1</a></li> <li><a href="/wiki/SOX2" title="SOX2">2</a></li> <li><a href="/wiki/SOX3" title="SOX3">3</a></li> <li><a href="/wiki/SOX4" title="SOX4">4</a></li> <li><a href="/wiki/SOX5" title="SOX5">5</a></li> <li><a href="/wiki/SOX6" title="SOX6">6</a></li> <li><a href="/wiki/SOX8" title="SOX8">8</a></li> <li><a href="/wiki/SOX9" title="SOX9">9</a></li> <li><a href="/wiki/SOX10" title="SOX10">10</a></li> <li><a href="/wiki/SOX11" title="SOX11">11</a></li> <li><a href="/wiki/SOX12" title="SOX12">12</a></li> <li><a href="/wiki/SOX13" title="SOX13">13</a></li> <li><a href="/wiki/SOX14" title="SOX14">14</a></li> <li><a href="/wiki/SOX15" title="SOX15">15</a></li> <li><a href="/wiki/SOX18" title="SOX18">18</a></li> <li><a href="/wiki/SOX21" title="SOX21">21</a></li></ul></li> <li><a href="/wiki/Testis_determining_factor" class="mw-redirect" title="Testis determining factor">SRY</a></li> <li><a href="/wiki/Structure_specific_recognition_protein_1" title="Structure specific recognition protein 1">SSRP1</a></li> <li><a href="/wiki/TCF/LEF_family" title="TCF/LEF family">TCF/LEF</a> <ul><li><i>TCF</i> <ul><li><a href="/wiki/TCF7" title="TCF7">1</a></li> <li><a href="/wiki/TCF3" title="TCF3">3</a></li> <li><a href="/wiki/TCF7L2" title="TCF7L2">4</a></li></ul></li> <li><a href="/wiki/Lymphoid_enhancer-binding_factor_1" title="Lymphoid enhancer-binding factor 1">LEF1</a></li></ul></li> <li><i>TOX</i> <ul><li><a href="/wiki/TOX" title="TOX">1</a></li> <li><a href="/wiki/TOX2" title="TOX2">2</a></li> <li><a href="/wiki/TOX3" title="TOX3">3</a></li> <li><a href="/wiki/TOX4" title="TOX4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.9) Grainyhead</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TFCP2" title="TFCP2">TFCP2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.10) Cold-shock domain</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CSDA_(gene)" title="CSDA (gene)">CSDA</a></li> <li><a href="/wiki/Y_box_binding_protein_1" title="Y box binding protein 1">YBX1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.11) Runt</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Core_binding_factor" title="Core binding factor">CBF</a> <ul><li><a href="/wiki/CBFA2T2" title="CBFA2T2">CBFA2T2</a></li> <li><a href="/wiki/CBFA2T3" title="CBFA2T3">CBFA2T3</a></li> <li><a href="/wiki/RUNX1" title="RUNX1">RUNX1</a></li> <li><a href="/wiki/RUNX2" title="RUNX2">RUNX2</a></li> <li><a href="/wiki/RUNX3" title="RUNX3">RUNX3</a></li> <li><a href="/wiki/RUNX1T1" title="RUNX1T1">RUNX1T1</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(0)_Other_transcription_factors" style="font-size:114%;margin:0 4em"><i> (0) Other transcription factors</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.2) HMGI(Y)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HMGA" title="HMGA">HMGA</a> <ul><li><a href="/wiki/HMGA1" title="HMGA1">1</a></li> <li><a href="/wiki/HMGA2" title="HMGA2">2</a></li></ul></li> <li><a href="/wiki/HBP1" title="HBP1">HBP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.3)</i> <a href="/wiki/Pocket_protein_family" title="Pocket protein family">Pocket domain</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Retinoblastoma_protein" title="Retinoblastoma protein">Rb</a></li> <li><a href="/wiki/Retinoblastoma-like_protein_1" title="Retinoblastoma-like protein 1">RBL1</a></li> <li><a href="/wiki/Retinoblastoma-like_protein_2" title="Retinoblastoma-like protein 2">RBL2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.5)</i> <a href="/wiki/Apetala_2" title="Apetala 2">AP-2</a><i>/</i><a href="/wiki/Ethylene-responsive_element_binding_protein" title="Ethylene-responsive element binding protein">EREBP</a><i>-related factors</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Apetala_2" title="Apetala 2">Apetala 2</a></li> <li><a href="/wiki/Ethylene-responsive_element_binding_protein" title="Ethylene-responsive element binding protein">EREBP</a></li> <li><a href="/wiki/B3_domain" title="B3 domain">B3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.6) Miscellaneous</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>ARID</i> <ul><li><a href="/wiki/ARID1A" title="ARID1A">1A</a></li> <li><a href="/wiki/ARID1B" title="ARID1B">1B</a></li> <li><a href="/wiki/ARID2" title="ARID2">2</a></li> <li><a href="/wiki/ARID3A" title="ARID3A">3A</a></li> <li><a href="/wiki/ARID3B" title="ARID3B">3B</a></li> <li><a href="/wiki/ARID4A" title="ARID4A">4A</a></li></ul></li> <li><a href="/wiki/Catabolite_activator_protein" title="Catabolite activator protein">CAP</a></li> <li><i>IFI</i> <ul><li><a href="/wiki/IFI16" title="IFI16">16</a></li> <li><a href="/wiki/IFI35" title="IFI35">35</a></li></ul></li> <li><a href="/wiki/MLL_(gene)" class="mw-redirect" title="MLL (gene)">MLL</a> <ul><li><a href="/wiki/MLL2" class="mw-redirect" title="MLL2">2</a></li> <li><a href="/wiki/MLL3" class="mw-redirect" title="MLL3">3</a></li> <li><a href="/wiki/MLLT1" title="MLLT1">T1</a></li></ul></li> <li><a href="/wiki/MNDA" title="MNDA">MNDA</a></li> <li><i>NFY</i> <ul><li><a href="/wiki/NFYA" title="NFYA">A</a></li> <li><a href="/wiki/NFYB" title="NFYB">B</a></li> <li><a href="/wiki/NFYC" title="NFYC">C</a></li></ul></li> <li><a href="/wiki/Rho_factor" title="Rho factor">Rho</a>/<a href="/wiki/Sigma_factor" title="Sigma factor">Sigma</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background-color: AntiqueWhite"><div><i>see also <a href="/wiki/Template:Transcription_factor_and_coregulator_deficiencies" title="Template:Transcription factor and coregulator deficiencies">transcription factor/coregulator deficiencies</a></i></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="JAK-STAT_signaling_pathway" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:JAK-STAT_signaling_pathway" title="Template:JAK-STAT signaling pathway"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:JAK-STAT_signaling_pathway" title="Template talk:JAK-STAT signaling pathway"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:JAK-STAT_signaling_pathway" title="Special:EditPage/Template:JAK-STAT signaling pathway"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="JAK-STAT_signaling_pathway" style="font-size:114%;margin:0 4em"><a href="/wiki/JAK-STAT_signaling_pathway" title="JAK-STAT signaling pathway">JAK-STAT signaling pathway</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">Ligand</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cytokine" title="Cytokine">Cytokine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cytokine_receptor" title="Cytokine receptor">Cytokine receptor</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Type_I_cytokine_receptor" title="Type I cytokine receptor">Type I cytokine receptor</a></li> <li><a href="/wiki/Type_II_cytokine_receptor" title="Type II cytokine receptor">Type II cytokine receptor</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Janus_kinase" title="Janus kinase">Janus kinase</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Janus_kinase_1" title="Janus kinase 1">JAK1</a></li> <li><a href="/wiki/Janus_kinase_2" title="Janus kinase 2">JAK2</a></li> <li><a href="/wiki/Janus_kinase_3" title="Janus kinase 3">JAK3</a></li> <li><a href="/wiki/Tyrosine_kinase_2" title="Tyrosine kinase 2">TYK2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Signal_transducing_adaptor_protein" title="Signal transducing adaptor protein">Adaptor proteins</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/STAT_protein" title="STAT protein">STAT</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">STAT1</a></li> <li><a href="/wiki/STAT2" title="STAT2">STAT2</a></li> <li><a href="/wiki/STAT3" title="STAT3">STAT3</a></li> <li><a href="/wiki/STAT4" title="STAT4">STAT4</a></li> <li><a href="/wiki/STAT5" title="STAT5">STAT5</a></li> <li><a href="/wiki/STAT6" title="STAT6">STAT6</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Protein_inhibitor_of_activated_STAT" title="Protein inhibitor of activated STAT">PIAS</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/PIAS1" title="PIAS1">PIAS1</a></li> <li><a href="/wiki/PIAS2" class="mw-redirect" title="PIAS2">PIAS2</a></li> <li><a href="/wiki/PIAS3" title="PIAS3">PIAS3</a></li> <li><a href="/wiki/PIAS4" title="PIAS4">PIAS4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Suppressor_of_cytokine_signalling" title="Suppressor of cytokine signalling">SOCS</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/SOCS1" class="mw-redirect" title="SOCS1">1</a></li> <li><a href="/wiki/SOCS2" title="SOCS2">2</a></li> <li><a href="/wiki/SOCS3" title="SOCS3">3</a></li> <li><a href="/wiki/SOCS4" title="SOCS4">4</a></li> <li><a href="/wiki/SOCS5" title="SOCS5">5</a></li> <li><a href="/wiki/SOCS6" title="SOCS6">6</a></li> <li><a href="/wiki/SOCS7" title="SOCS7">7</a></li> <li><a href="/wiki/CISH_(gene)" class="mw-redirect" title="CISH (gene)">CISH</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interferon_regulatory_factors" title="Interferon regulatory factors">IRF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/IRF1" title="IRF1">IRF1</a></li> <li><a href="/wiki/IRF2" title="IRF2">IRF2</a></li> <li><a href="/wiki/IRF3" title="IRF3">IRF3</a></li> <li><a href="/wiki/IRF4" title="IRF4">IRF4</a></li> <li><a href="/wiki/IRF5" title="IRF5">IRF5</a></li> <li><a href="/wiki/IRF6" title="IRF6">IRF6</a></li> <li><a href="/wiki/IRF7" title="IRF7">IRF7</a></li> <li><a href="/wiki/IRF8" title="IRF8">IRF8</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Cytokine_receptor_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Cytokine_receptor_modulators" title="Template talk:Cytokine receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Cytokine_receptor_modulators" title="Special:EditPage/Template:Cytokine receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cytokine_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Cytokine_receptor" title="Cytokine receptor">Cytokine receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Chemokine_receptor" title="Chemokine receptor">Chemokine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Chemokine_receptor_modulators" title="Template:Chemokine receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Colony-stimulating_factor_receptor" class="mw-redirect" title="Colony-stimulating factor receptor">CSF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Erythropoietin_receptor" title="Erythropoietin receptor">Erythropoietin</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=ARA-290&action=edit&redlink=1" class="new" title="ARA-290 (page does not exist)">ARA-290</a></li> <li><a href="/w/index.php?title=Asialo_erythropoietin&action=edit&redlink=1" class="new" title="Asialo erythropoietin (page does not exist)">Asialo erythropoietin</a></li> <li><a href="/w/index.php?title=Carbamylated_erythropoietin&action=edit&redlink=1" class="new" title="Carbamylated erythropoietin (page does not exist)">Carbamylated erythropoietin</a></li> <li><a href="/w/index.php?title=CNTO-530&action=edit&redlink=1" class="new" title="CNTO-530 (page does not exist)">CNTO-530</a></li> <li><a href="/wiki/Darbepoetin_alfa" title="Darbepoetin alfa">Darbepoetin alfa</a></li> <li><a href="/wiki/Epoetin_alfa" title="Epoetin alfa">Epoetin alfa</a></li> <li><a href="/wiki/Epoetin_beta" title="Epoetin beta">Epoetin beta</a></li> <li><a href="/w/index.php?title=Epoetin_delta&action=edit&redlink=1" class="new" title="Epoetin delta (page does not exist)">Epoetin delta</a></li> <li><a href="/w/index.php?title=Epoetin_epsilon&action=edit&redlink=1" class="new" title="Epoetin epsilon (page does not exist)">Epoetin epsilon</a></li> <li><a href="/w/index.php?title=Epoetin_gamma&action=edit&redlink=1" class="new" title="Epoetin gamma (page does not exist)">Epoetin gamma</a></li> <li><a href="/w/index.php?title=Epoetin_kappa&action=edit&redlink=1" class="new" title="Epoetin kappa (page does not exist)">Epoetin kappa</a></li> <li><a href="/w/index.php?title=Epoetin_omega&action=edit&redlink=1" class="new" title="Epoetin omega (page does not exist)">Epoetin omega</a></li> <li><a href="/wiki/Epoetin_theta" title="Epoetin theta">Epoetin theta</a></li> <li><a href="/wiki/Epoetin_zeta" class="mw-redirect" title="Epoetin zeta">Epoetin zeta</a></li> <li><a href="/wiki/Erythropoietin" title="Erythropoietin">Erythropoietin (EPO)</a></li> <li><a href="/w/index.php?title=Erythropoietin-Fc&action=edit&redlink=1" class="new" title="Erythropoietin-Fc (page does not exist)">Erythropoietin-Fc</a></li> <li><a href="/wiki/Methoxy_polyethylene_glycol-epoetin_beta" title="Methoxy polyethylene glycol-epoetin beta">Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)</a></li> <li><a href="/wiki/Peginesatide" title="Peginesatide">Peginesatide</a></li> <li><a href="/w/index.php?title=Pegol_sihematide&action=edit&redlink=1" class="new" title="Pegol sihematide (page does not exist)">Pegol sihematide (EPO-018B)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Granulocyte_colony-stimulating_factor_receptor" title="Granulocyte colony-stimulating factor receptor">G-CSF (CSF3)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Filgrastim" title="Filgrastim">Filgrastim</a></li> <li><a href="/wiki/Granulocyte_colony-stimulating_factor" title="Granulocyte colony-stimulating factor">Granulocyte colony-stimulating factor</a></li> <li><a href="/wiki/Lenograstim" title="Lenograstim">Lenograstim</a></li> <li><a href="/w/index.php?title=Leridistim&action=edit&redlink=1" class="new" title="Leridistim (page does not exist)">Leridistim</a></li> <li><a href="/wiki/Lipegfilgrastim" title="Lipegfilgrastim">Lipegfilgrastim</a></li> <li><a href="/w/index.php?title=Nartograstim&action=edit&redlink=1" class="new" title="Nartograstim (page does not exist)">Nartograstim</a></li> <li><a href="/wiki/Pegfilgrastim" title="Pegfilgrastim">Pegfilgrastim</a></li> <li><a href="/w/index.php?title=Pegnartograstim&action=edit&redlink=1" class="new" title="Pegnartograstim (page does not exist)">Pegnartograstim</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor_receptor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor receptor">GM-CSF (CSF2)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ecogramostim&action=edit&redlink=1" class="new" title="Ecogramostim (page does not exist)">Ecogramostim</a></li> <li><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor">Granulocyte macrophage colony-stimulating factor</a></li> <li><a href="/w/index.php?title=Milodistim&action=edit&redlink=1" class="new" title="Milodistim (page does not exist)">Milodistim</a></li> <li><a href="/wiki/Molgramostim" title="Molgramostim">Molgramostim</a></li> <li><a href="/w/index.php?title=Regramostim&action=edit&redlink=1" class="new" title="Regramostim (page does not exist)">Regramostim</a></li> <li><a href="/wiki/Sargramostim" title="Sargramostim">Sargramostim</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Mavrilimumab" title="Mavrilimumab">Mavrilimumab</a></li> <li><a href="/wiki/Namilumab" title="Namilumab">Namilumab</a></li> <li><a href="/wiki/Otilimab" title="Otilimab">Otilimab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Macrophage_colony-stimulating_factor_receptor" class="mw-redirect" title="Macrophage colony-stimulating factor receptor">M-CSF (CSF1)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Cilmostim&action=edit&redlink=1" class="new" title="Cilmostim (page does not exist)">Cilmostim</a></li> <li><a href="/wiki/Interleukin-34" class="mw-redirect" title="Interleukin-34">Interleukin-34</a></li> <li><a href="/w/index.php?title=Lanimostim&action=edit&redlink=1" class="new" title="Lanimostim (page does not exist)">Lanimostim</a></li> <li><a href="/wiki/Macrophage_colony-stimulating_factor" title="Macrophage colony-stimulating factor">Macrophage colony-stimulating factor</a></li> <li><a href="/w/index.php?title=Mirimostim&action=edit&redlink=1" class="new" title="Mirimostim (page does not exist)">Mirimostim</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CD117" class="mw-redirect" title="CD117">SCF (c-Kit)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Growth_factor_receptor_modulators" title="Template:Growth factor receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Thrombopoietin_receptor" title="Thrombopoietin receptor">Thrombopoietin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Eltrombopag" title="Eltrombopag">Eltrombopag</a></li> <li><a href="/w/index.php?title=Pegacaristim&action=edit&redlink=1" class="new" title="Pegacaristim (page does not exist)">Pegacaristim</a></li> <li><a href="/wiki/Promegapoietin" title="Promegapoietin">Promegapoietin</a></li> <li><a href="/wiki/Romiplostim" title="Romiplostim">Romiplostim</a></li> <li><a href="/wiki/Thrombopoietin" title="Thrombopoietin">Thrombopoietin (THPO, MGDF)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interferon_receptor" class="mw-redirect" title="Interferon receptor">Interferon</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interferon-alpha/beta_receptor" title="Interferon-alpha/beta receptor">IFNAR (α/β, I)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Albinterferon" title="Albinterferon">Albinterferon</a></li> <li><a href="/wiki/Interferon_alpha" class="mw-redirect" title="Interferon alpha">Interferon alpha (interferon alfa, IFN-α)</a></li> <li><a href="/wiki/Interferon_alfa" title="Interferon alfa">Interferon alfa</a> (<a href="/wiki/Interferon_alpha_1" class="mw-redirect" title="Interferon alpha 1">IFNA1</a>, <a href="/wiki/IFNA2" title="IFNA2">IFNA2</a>, <a href="/wiki/IFNA4" title="IFNA4">IFNA4</a>, <a href="/wiki/IFNA5" title="IFNA5">IFNA5</a>, <a href="/wiki/IFNA6" title="IFNA6">IFNA6</a>, <a href="/wiki/IFNA7" title="IFNA7">IFNA7</a>, <a href="/wiki/IFNA8" title="IFNA8">IFNA8</a>, <a href="/wiki/IFNA10" title="IFNA10">IFNA10</a>, <a href="/wiki/IFNA13" title="IFNA13">IFNA13</a>, <a href="/wiki/IFNA14" title="IFNA14">IFNA14</a>, <a href="/wiki/IFNA16" title="IFNA16">IFNA16</a>, <a href="/wiki/IFNA17" title="IFNA17">IFNA17</a>, <a href="/wiki/IFNA21" title="IFNA21">IFNA21</a>)</li> <li><a href="/wiki/Interferon_alfa_2a" class="mw-redirect" title="Interferon alfa 2a">Interferon alfa 2a</a></li> <li><a href="/wiki/Interferon_alfa_2b" class="mw-redirect" title="Interferon alfa 2b">Interferon alfa 2b</a></li> <li><a href="/w/index.php?title=Interferon_alfa_n1&action=edit&redlink=1" class="new" title="Interferon alfa n1 (page does not exist)">Interferon alfa n1</a></li> <li><a href="/wiki/Interferon_alfacon-1" title="Interferon alfacon-1">Interferon alfacon-1</a></li> <li><a href="/wiki/Interferon_alpha-n3" title="Interferon alpha-n3">Interferon alpha-n3</a></li> <li><a href="/wiki/Interferon_beta" class="mw-redirect" title="Interferon beta">Interferon beta (IFN-β)</a> (<a href="/wiki/IFNB1" title="IFNB1">IFNB1</a>, <a href="/w/index.php?title=IFNB3&action=edit&redlink=1" class="new" title="IFNB3 (page does not exist)">IFNB3</a>)</li> <li><a href="/wiki/Interferon_beta_1a" class="mw-redirect" title="Interferon beta 1a">Interferon beta 1a</a></li> <li><a href="/wiki/Interferon_beta_1b" class="mw-redirect" title="Interferon beta 1b">Interferon beta 1b</a></li> <li><a href="/wiki/Interferon_kappa" class="mw-redirect" title="Interferon kappa">Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)</a></li> <li><a href="/wiki/Interferon_omega" class="mw-redirect" title="Interferon omega">Interferon omega (IFN-ω, IFNW1)</a></li> <li><a href="/wiki/Peginterferon_alfa-2a" title="Peginterferon alfa-2a">Peginterferon alfa-2a</a></li> <li><a href="/wiki/Peginterferon_alfa-2b" title="Peginterferon alfa-2b">Peginterferon alfa-2b</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Anifrolumab" title="Anifrolumab">Anifrolumab</a></li> <li><a href="/wiki/Faralimomab" title="Faralimomab">Faralimomab</a></li> <li><a href="/w/index.php?title=MEDI-545&action=edit&redlink=1" class="new" title="MEDI-545 (page does not exist)">MEDI-545</a></li> <li><a href="/wiki/Rontalizumab" title="Rontalizumab">Rontalizumab</a></li> <li><a href="/wiki/Sifalimumab" title="Sifalimumab">Sifalimumab</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/w/index.php?title=Bifarcept&action=edit&redlink=1" class="new" title="Bifarcept (page does not exist)">Bifarcept</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interferon-gamma_receptor" title="Interferon-gamma receptor">IFNGR (γ, II)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interferon_gamma" title="Interferon gamma">Interferon gamma (IFN-γ)</a></li> <li><a href="/wiki/Interferon_gamma_1b" class="mw-redirect" title="Interferon gamma 1b">Interferon gamma 1b</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Emapalumab" title="Emapalumab">Emapalumab</a></li> <li><a href="/wiki/Fontolizumab" title="Fontolizumab">Fontolizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interferon-lambda_receptor" class="mw-redirect" title="Interferon-lambda receptor">IFNLR (λ, III)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See IL-28R (IFNLR) <a href="/wiki/Template:Interleukin_receptor_modulators" title="Template:Interleukin receptor modulators">here</a> instead.</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Interleukin_receptor_modulators" title="Template:Interleukin receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Transforming_growth_factor_beta_receptor" class="mw-redirect" title="Transforming growth factor beta receptor">TGFβ</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:TGF%CE%B2_receptor_superfamily_modulators" title="Template:TGFβ receptor superfamily modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Tumor_necrosis_factor_receptor" class="mw-redirect" title="Tumor necrosis factor receptor">TNF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:TNF_receptor_superfamily_modulators" title="Template:TNF receptor superfamily modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Janus_kinase" title="Janus kinase">JAK</a><br /><small>(<a href="/wiki/Janus_kinase_inhibitor" title="Janus kinase inhibitor">inhibitors</a>)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/JAK1" class="mw-redirect" title="JAK1">JAK1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Abrocitinib" title="Abrocitinib">Abrocitinib</a></li> <li><a href="/wiki/Baricitinib" title="Baricitinib">Baricitinib</a></li> <li><a href="/wiki/Deuruxolitinib" title="Deuruxolitinib">Deuruxolitinib</a></li> <li><a href="/wiki/Filgotinib" title="Filgotinib">Filgotinib</a></li> <li><a href="/wiki/Momelotinib" title="Momelotinib">Momelotinib</a></li> <li><a href="/wiki/Oclacitinib" title="Oclacitinib">Oclacitinib</a></li> <li><a href="/wiki/Peficitinib" title="Peficitinib">Peficitinib</a></li> <li><a href="/wiki/Ruxolitinib" title="Ruxolitinib">Ruxolitinib</a></li> <li><a href="/wiki/Tofacitinib" title="Tofacitinib">Tofacitinib (tasocitinib)</a></li> <li><a href="/wiki/Upadacitinib" title="Upadacitinib">Upadacitinib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/JAK2" class="mw-redirect" title="JAK2">JAK2</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Atiprimod" title="Atiprimod">Atiprimod</a></li> <li><a href="/w/index.php?title=AZD-1480&action=edit&redlink=1" class="new" title="AZD-1480 (page does not exist)">AZD-1480</a></li> <li><a href="/wiki/Baricitinib" title="Baricitinib">Baricitinib</a></li> <li><a href="/wiki/CHZ868" title="CHZ868">CHZ868</a></li> <li><a href="/wiki/Cucurbitacin_I" class="mw-redirect" title="Cucurbitacin I">Cucurbitacin I (elatericin B, JSI-124)</a></li> <li><a href="/wiki/CYT387" class="mw-redirect" title="CYT387">CYT387</a></li> <li><a href="/wiki/Deuruxolitinib" title="Deuruxolitinib">Deuruxolitinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/w/index.php?title=NSC-7908&action=edit&redlink=1" class="new" title="NSC-7908 (page does not exist)">NSC-7908</a></li> <li><a href="/w/index.php?title=NSC-33994&action=edit&redlink=1" class="new" title="NSC-33994 (page does not exist)">NSC-33994</a></li> <li><a href="/wiki/Pacritinib" title="Pacritinib">Pacritinib</a></li> <li><a href="/wiki/Peficitinib" title="Peficitinib">Peficitinib</a></li> <li><a href="/wiki/Ruxolitinib" title="Ruxolitinib">Ruxolitinib</a></li> <li><a href="/w/index.php?title=SD-1008&action=edit&redlink=1" class="new" title="SD-1008 (page does not exist)">SD-1008</a></li> <li><a href="/wiki/Tofacitinib" title="Tofacitinib">Tofacitinib (tasocitinib)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/JAK3" class="mw-redirect" title="JAK3">JAK3</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Cercosporamide&action=edit&redlink=1" class="new" title="Cercosporamide (page does not exist)">Cercosporamide</a></li> <li><a href="/wiki/Decernotinib" title="Decernotinib">Decernotinib (VX-509)</a></li> <li><a href="/wiki/Peficitinib" title="Peficitinib">Peficitinib</a></li> <li><a href="/wiki/Ritlecitinib" title="Ritlecitinib">Ritlecitinib</a></li> <li><a href="/w/index.php?title=TCS-21311&action=edit&redlink=1" class="new" title="TCS-21311 (page does not exist)">TCS-21311</a></li> <li><a href="/wiki/Tofacitinib" title="Tofacitinib">Tofacitinib (tasocitinib)</a></li> <li><a href="/w/index.php?title=WHI-P_154&action=edit&redlink=1" class="new" title="WHI-P 154 (page does not exist)">WHI-P 154</a></li> <li><a href="/w/index.php?title=ZM-39923&action=edit&redlink=1" class="new" title="ZM-39923 (page does not exist)">ZM-39923</a></li> <li><a href="/w/index.php?title=ZM-449829&action=edit&redlink=1" class="new" title="ZM-449829 (page does not exist)">ZM-449829</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Tyrosine_kinase_2" title="Tyrosine kinase 2">TYK2</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Deucravacitinib" title="Deucravacitinib">Deucravacitinib</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Additional cytokines:</i> <a href="/wiki/Cardiotrophin_1" title="Cardiotrophin 1">Cardiotrophin 1 (CT-1)</a></li> <li><a href="/wiki/FMS-like_tyrosine_kinase_3_ligand" title="FMS-like tyrosine kinase 3 ligand">FMS-like tyrosine kinase 3 ligand (FLT3L)</a></li> <li><a href="/wiki/Leukemia_inhibitory_factor" title="Leukemia inhibitory factor">Leukemia/leukocyte inhibitory factor (LIF)</a></li> <li><a href="/wiki/Oncostatin_M" title="Oncostatin M">Oncostatin M (OSM)</a></li> <li><a href="/wiki/Thymic_stromal_lymphopoietin" title="Thymic stromal lymphopoietin">Thymic stromal lymphopoietin (TSLP)</a></li></ul> <ul><li><i>Additional cytokine receptor modulators:</i> <a href="/w/index.php?title=Emfilermin&action=edit&redlink=1" class="new" title="Emfilermin (page does not exist)">Emfilermin</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/wiki/Midostaurin" title="Midostaurin">Midostaurin</a></li> <li><a href="/wiki/Quizartinib" title="Quizartinib">Quizartinib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" 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