CINXE.COM
Patients - Calico
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pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default" style=""> <div class="sizing-container_wrapper"> <h1 id="heading_block_1c5be78a4dcaa93c7b959a7eb4d27280" class="custom_heading from-bottom__0 mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default h2 align-left align-left-mobile"> Clinical Trials </h1> <p>Calico is committed to translating our research focused on aging and age-related diseases into insights that enable the development of novel therapies.</p> <p>With our collaborative partners we are designing and conducting clinical studies with the highest integrity and ethical standards, in accordance with applicable regulations. We are devoted to the safety and well-being of all the people who take part in our clinical trials.</p> <h2 id="heading_block_5e5d2d64ebd918db5a46fbea500720d5" class="custom_heading from-bottom__0 mt-5 mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default align-left align-left-mobile"> Programs </h2> <ul class="table_list mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default label-font-size-medium content-font-size-auto" id="table_listblock_ad24846da7e75099b06b4273294fdddd" style="--label-color:#28a059;"> <li class="table_list__item from-bottom__0"> <div class="table_list__heading"> <a href="https://www.calicolabs.com/clinical-trial-vanishing-white-matter/" target="_self">Vanishing White Matter</a> </div> <div class="table_list__content"> <p><a href="https://clinicaltrials.gov/study/NCT05757141">A Phase 1b/2 Open-label Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy Following Fosigotifator Administration in Adult and Pediatric Subjects With Vanishing White Matter Disease</a></p> </div> </li> <li class="table_list__item from-bottom__0"> <div class="table_list__heading"> <a href="https://www.calicolabs.com/clinical-trial-amyotrophic-lateral-sclerosis-als/" target="_self">Amyotrophic Lateral Sclerosis</a> </div> <div class="table_list__content"> <p><a href="https://clinicaltrials.gov/ct2/show/NCT05740813?term=NCT05740813&draw=2&rank=1" target="_blank" rel="noopener">HEALEY ALS Platform trial – Regimen F ABBV-CLS-7262</a></p> <hr /> <p><a href="https://www.clinicaltrials.gov/ct2/show/NCT04948645?term=calico&draw=2" target="_blank" rel="noopener">A Randomized, Double-Blind, Placebo-Controlled Study to Assess Safety and Pharmacokinetics of ABBV-CLS-7262 in Patients With Amyotrophic Lateral Sclerosis.</a></p> </div> </li> <li class="table_list__item from-bottom__0"> <div class="table_list__heading"> Oncology </div> <div class="table_list__content"> <p><a href="https://clinicaltrials.gov/ct2/show/NCT04417465?term=calico&draw=2&rank=3" target="_blank" rel="noopener"><span class="s1">First-In-Human Study With ABBV-CLS-579 When Given Alone Or In Combination With Programmed Cell Death-1 Inhibitor In Participants With Locally Advanced Or Metastatic Tumors</span></a></p> <hr /> <p><a href="https://clinicaltrials.gov/ct2/show/NCT04777994?term=calico&draw=2&rank=2" target="_blank" rel="noopener"><span class="s1">A Phase 1 Study With ABBV-CLS-484 in Subjects With Locally Advanced or Metastatic Tumors</span></a></p> </div> </li> </ul> <p>Calico registers interventional clinical trials conducted in patients on <a href="https://www.clinicaltrials.gov/" target="_blank" rel="noreferrer noopener"><strong>www.clinicaltrials.gov</strong></a>.</p> <p>If you are a patient interested in one of our clinical trials, please visit <a href="https://www.clinicaltrials.gov/" target="_blank" rel="noreferrer noopener"><strong>www.clinicaltrials.gov</strong></a> to learn more.</p> <h2 id="heading_block_29438dd746e1b8dfa0d3a85c79f3b0e0" class="custom_heading from-bottom__0 mt-5 mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default align-left align-left-mobile"> Expanded Access </h2> <p>Sometimes called “compassionate use”, Expanded Access involves the use of an investigational drug when a patient with a serious disease or life-threatening condition is unable to participate in a clinical trial. Calico does not currently offer an Expanded Access program; participation in our clinical trials is the only way for patients to gain access to any of Calico’s investigational drugs. As more data on the safety and efficacy of our investigational drugs become available, we will continuously review and may update our policy on Expanded Access.</p> <p>If you have additional questions, please contact us at <a href="mailto:clinicaltrialcommunication@calicolabs.com"><strong>clinicaltrialcommunication@calicolabs.com</strong></a>.</p> </div> </div> </div> </section> </div><!-- .entry-content --> </article><!-- #post-2390 --> </main><!-- #main --> </div><!-- #primary --> </div><!-- #content --> <footer id="colophon" class="site-footer"> <div class="site-footer__container container"> <div class="site-footer__logo from-bottom__0"> <svg height="95" viewBox="0 0 95 95" width="95"><g fill="none" fill-rule="evenodd"><path fill="#25BD56" d="M53.646 55.464c-4.063 3.286-9.981 2.608-13.22-1.514-3.237-4.122-2.57-10.127 1.492-13.414a9.3 9.3 0 0 1 11.73.002L57 36.275c-6.382-5.167-15.682-4.105-20.773 2.371-5.09 6.476-4.045 15.914 2.337 21.08a14.613 14.613 0 0 0 18.432.003l-3.35-4.265z"></path><path fill="#25BD56" d="M56.852 65.326c-9.845 5.165-22.014 1.371-27.18-8.474-5.164-9.846-1.37-22.014 8.476-27.18 9.845-5.164 22.014-1.37 27.18 8.475a20.131 20.131 0 0 1-4.48 24.423l3.558 4.019c10.543-9.337 11.52-25.453 2.183-35.996-9.337-10.542-25.452-11.52-35.995-2.183-10.543 9.337-11.52 25.453-2.184 35.995a25.5 25.5 0 0 0 30.936 5.675l-2.494-4.754z"></path><path fill="#25BD56" d="M77.47 36.48c6.165 16.058-2.033 34.005-18.31 40.086-16.271 6.08-34.458-1.999-40.63-18.047-6.169-16.055 2.024-34.004 18.3-40.09 13.559-5.07 28.875-.36 37.11 11.415l4.511-3.071C66.847 10.183 43.807 6.013 26.99 17.46c-16.818 11.448-21.044 34.177-9.44 50.767 11.604 16.59 34.644 20.76 51.462 9.313 14.011-9.537 19.617-27.274 13.584-42.976l-5.125 1.917z"></path><g><path fill="#25BD56" d="M27.92 10.348C48.47-.432 73.87 7.488 84.65 28.04c10.78 20.55 2.861 45.948-17.687 56.73-20.551 10.78-45.951 2.86-56.732-17.69C1.249 49.96 5.108 28.92 19.582 16.1l-3.595-4.059c-19.614 17.372-21.432 47.356-4.06 66.97C29.3 98.627 59.28 100.446 78.896 83.076c19.615-17.371 21.434-47.355 4.063-66.97C68.486-.236 44.73-4.595 25.4 5.547l2.519 4.801z" mask="url(#b)"></path></g></g></svg> </div> <div class="site-footer__content"> <div class="site-footer__menus"> <div class="site-footer__menu from-bottom__1 from-bottom-mb__0 hide_on_mobile"> <h5 class="h5_small">About Us</h5> <ul> <li> <a class="animated_underline_link small" href="/research-technology/" target="">Research & Technology</a> </li> <li> <a class="animated_underline_link small" href="/drug-development/" target="">Drug Development</a> </li> <li> <a class="animated_underline_link small" href="/people/" target="">Leadership</a> </li> <li> <a class="animated_underline_link small" href="/partnering/" target="">Partnering</a> </li> <li> <a class="animated_underline_link small" href="/life-at-calico/" target="">Life at Calico</a> </li> </ul> </div> <div class="site-footer__menu from-bottom__2 from-bottom-mb__0 hide_on_mobile"> <h5 class="h5_small">Resources</h5> <ul> <li> <a class="animated_underline_link small" href="/publications/" target="">Publications</a> </li> <li> <a class="animated_underline_link small" href="/calico-stories/" target="">Calico Stories</a> </li> <li> <a class="animated_underline_link small" href="/news-and-media/" target="">News & Media</a> </li> <li> <a class="animated_underline_link small" href="/patients/" target="">Patients</a> </li> </ul> </div> <div class="site-footer__menu from-bottom__3 from-bottom-mb__0 hide_on_mobile"> <h5 class="h5_small">Contact Us</h5> <ul> <li> <a class="animated_underline_link small" href="/contact-us/" target="">Contact Us</a> </li> <li> <a class="animated_underline_link small" href="/careers/" target="">Join Us</a> </li> </ul> </div> <div class="site-footer__menu from-bottom__4 from-bottom-mb__1 show_on_mobile"> <h5 class="h5_small">Follow Us</h5> <ul> <li> <a class="animated_underline_link small" href="https://twitter.com/calico" target="_blank">X</a> </li> <li> <a class="animated_underline_link small" href="https://www.linkedin.com/company/calico-life-sciences-llc" target="_blank">LinkedIn</a> </li> </ul> </div> <div class="site-footer__menu from-bottom__0 from-bottom-mb__2 show_on_mobile"> <ul> <li> <a class="animated_underline_link small" href="/privacy-policy/" target="">Privacy Policy</a> </li> <li> <a class="animated_underline_link small" href="/privacy-policy/#collection-notice" target="">Notice at Collection</a> </li> <li> <a class="animated_underline_link small" href="/terms-of-use/" target="">Terms of Use</a> </li> <li> <a class="animated_underline_link small" href="/code-of-conduct/" target="">Code of Conduct</a> </li> </ul> </div> </div> <div class="site-footer__copyright from-bottom__0 from-bottom-mb__3"> <span>2024 Calico Life Sciences LLC. 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We can't have a reference of the opened windows, so we should attempt to refresh only the windows that has opened popups. */ window._nslHasOpenedPopup = false; window._nslWebViewNoticeElement = null; window.NSLPopup = function (url, title, w, h) { /** * Cross-Origin-Opener-Policy blocked the access to the opener */ if (typeof BroadcastChannel === "function") { const _nslLoginBroadCastChannel = new BroadcastChannel('nsl_login_broadcast_channel'); _nslLoginBroadCastChannel.onmessage = (event) => { if (window?._nslHasOpenedPopup && event.data?.action === 'redirect') { window._nslHasOpenedPopup = false; const url = event.data?.href; _nslLoginBroadCastChannel.close(); if (typeof window.nslRedirect === 'function') { window.nslRedirect(url); } else { window.opener.location = url; } } }; } const userAgent = navigator.userAgent, mobile = function () { return /\b(iPhone|iP[ao]d)/.test(userAgent) || /\b(iP[ao]d)/.test(userAgent) || /Android/i.test(userAgent) || /Mobile/i.test(userAgent); }, screenX = window.screenX !== undefined ? window.screenX : window.screenLeft, screenY = window.screenY !== undefined ? window.screenY : window.screenTop, outerWidth = window.outerWidth !== undefined ? window.outerWidth : document.documentElement.clientWidth, outerHeight = window.outerHeight !== undefined ? window.outerHeight : document.documentElement.clientHeight - 22, targetWidth = mobile() ? null : w, targetHeight = mobile() ? null : h, left = parseInt(screenX + (outerWidth - targetWidth) / 2, 10), right = parseInt(screenY + (outerHeight - targetHeight) / 2.5, 10), features = []; if (targetWidth !== null) { features.push('width=' + targetWidth); } if (targetHeight !== null) { features.push('height=' + targetHeight); } features.push('left=' + left); features.push('top=' + right); features.push('scrollbars=1'); const newWindow = window.open(url, title, features.join(',')); if (window.focus) { newWindow.focus(); } window._nslHasOpenedPopup = true; return newWindow; }; let isWebView = null; function checkWebView() { if (isWebView === null) { function _detectOS(ua) { if (/Android/.test(ua)) { return "Android"; } else if (/iPhone|iPad|iPod/.test(ua)) { return "iOS"; } else if (/Windows/.test(ua)) { return "Windows"; } else if (/Mac OS X/.test(ua)) { return "Mac"; } else if (/CrOS/.test(ua)) { return "Chrome OS"; } else if (/Firefox/.test(ua)) { return "Firefox OS"; } return ""; } function _detectBrowser(ua) { let android = /Android/.test(ua); if (/Opera Mini/.test(ua) || / OPR/.test(ua) || / OPT/.test(ua)) { return "Opera"; } else if (/CriOS/.test(ua)) { return "Chrome for iOS"; } else if (/Edge/.test(ua)) { return "Edge"; } else if (android && /Silk\//.test(ua)) { return "Silk"; } else if (/Chrome/.test(ua)) { return "Chrome"; } else if (/Firefox/.test(ua)) { return "Firefox"; } else if (android) { return "AOSP"; } else if (/MSIE|Trident/.test(ua)) { return "IE"; } else if (/Safari\//.test(ua)) { return "Safari"; } else if (/AppleWebKit/.test(ua)) { return "WebKit"; } return ""; } function _detectBrowserVersion(ua, browser) { if (browser === "Opera") { return /Opera Mini/.test(ua) ? _getVersion(ua, "Opera Mini/") : / OPR/.test(ua) ? _getVersion(ua, " OPR/") : _getVersion(ua, " OPT/"); } else if (browser === "Chrome for iOS") { return _getVersion(ua, "CriOS/"); } else if (browser === "Edge") { return _getVersion(ua, "Edge/"); } else if (browser === "Chrome") { return _getVersion(ua, "Chrome/"); } else if (browser === "Firefox") { return _getVersion(ua, "Firefox/"); } else if (browser === "Silk") { return _getVersion(ua, "Silk/"); } else if (browser === "AOSP") { return _getVersion(ua, "Version/"); } else if (browser === "IE") { return /IEMobile/.test(ua) ? _getVersion(ua, "IEMobile/") : /MSIE/.test(ua) ? _getVersion(ua, "MSIE ") : _getVersion(ua, "rv:"); } else if (browser === "Safari") { return _getVersion(ua, "Version/"); } else if (browser === "WebKit") { return _getVersion(ua, "WebKit/"); } return "0.0.0"; } function _getVersion(ua, token) { try { return _normalizeSemverString(ua.split(token)[1].trim().split(/[^\w\.]/)[0]); } catch (o_O) { } return "0.0.0"; } function _normalizeSemverString(version) { const ary = version.split(/[\._]/); return (parseInt(ary[0], 10) || 0) + "." + (parseInt(ary[1], 10) || 0) + "." + (parseInt(ary[2], 10) || 0); } function _isWebView(ua, os, browser, version, options) { switch (os + browser) { case "iOSSafari": return false; case "iOSWebKit": return _isWebView_iOS(options); case "AndroidAOSP": return false; case "AndroidChrome": return parseFloat(version) >= 42 ? /; wv/.test(ua) : /\d{2}\.0\.0/.test(version) ? true : _isWebView_Android(options); } return false; } function _isWebView_iOS(options) { const document = (window["document"] || {}); if ("WEB_VIEW" in options) { return options["WEB_VIEW"]; } return !("fullscreenEnabled" in document || "webkitFullscreenEnabled" in document || false); } function _isWebView_Android(options) { if ("WEB_VIEW" in options) { return options["WEB_VIEW"]; } return !("requestFileSystem" in window || "webkitRequestFileSystem" in window || false); } const options = {}, nav = window.navigator || {}, ua = nav.userAgent || "", os = _detectOS(ua), browser = _detectBrowser(ua), browserVersion = _detectBrowserVersion(ua, browser); isWebView = _isWebView(ua, os, browser, browserVersion, options); } return isWebView; } function isAllowedWebViewForUserAgent(provider) { const facebookAllowedWebViews = [ 'Instagram', 'FBAV', 'FBAN' ]; let whitelist = []; if (provider && provider === 'facebook') { whitelist = facebookAllowedWebViews; } const nav = window.navigator || {}, ua = nav.userAgent || ""; if (whitelist.length && ua.match(new RegExp(whitelist.join('|')))) { return true; } return false; } function disableButtonInWebView(providerButtonElement) { if (providerButtonElement) { providerButtonElement.classList.add('nsl-disabled-provider'); providerButtonElement.setAttribute('href', '#'); providerButtonElement.addEventListener('pointerdown', (e) => { if (!window._nslWebViewNoticeElement) { window._nslWebViewNoticeElement = document.createElement('div'); window._nslWebViewNoticeElement.id = "nsl-notices-fallback"; window._nslWebViewNoticeElement.addEventListener('pointerdown', function (e) { this.parentNode.removeChild(this); window._nslWebViewNoticeElement = null; }); const webviewNoticeHTML = '<div class="error"><p>' + scriptOptions._localizedStrings.webview_notification_text + '</p></div>'; window._nslWebViewNoticeElement.insertAdjacentHTML("afterbegin", webviewNoticeHTML); document.body.appendChild(window._nslWebViewNoticeElement); } }); } } window._nslDOMReady(function () { window.nslRedirect = function (url) { if (scriptOptions._redirectOverlay) { const overlay = document.createElement('div'); overlay.id = "nsl-redirect-overlay"; let overlayHTML = ''; const overlayContainer = "<div id='nsl-redirect-overlay-container'>", overlayContainerClose = "</div>", overlaySpinner = "<div id='nsl-redirect-overlay-spinner'></div>", overlayTitle = "<p id='nsl-redirect-overlay-title'>" + scriptOptions._localizedStrings.redirect_overlay_title + "</p>", overlayText = "<p id='nsl-redirect-overlay-text'>" + scriptOptions._localizedStrings.redirect_overlay_text + "</p>"; switch (scriptOptions._redirectOverlay) { case "overlay-only": break; case "overlay-with-spinner": overlayHTML = overlayContainer + overlaySpinner + overlayContainerClose; break; default: overlayHTML = overlayContainer + overlaySpinner + overlayTitle + overlayText + overlayContainerClose; break; } overlay.insertAdjacentHTML("afterbegin", overlayHTML); document.body.appendChild(overlay); } window.location = url; }; let targetWindow = scriptOptions._targetWindow || 'prefer-popup', lastPopup = false; document.addEventListener('click', function (e) { if (e.target) { const buttonLinkElement = e.target.closest('a[data-plugin="nsl"][data-action="connect"]') || e.target.closest('a[data-plugin="nsl"][data-action="link"]'); if (buttonLinkElement) { if (lastPopup && !lastPopup.closed) { e.preventDefault(); lastPopup.focus(); } else { let href = buttonLinkElement.href, success = false; if (href.indexOf('?') !== -1) { href += '&'; } else { href += '?'; } const redirectTo = buttonLinkElement.dataset.redirect; if (redirectTo === 'current') { href += 'redirect=' + encodeURIComponent(window.location.href) + '&'; } else if (redirectTo && redirectTo !== '') { href += 'redirect=' + encodeURIComponent(redirectTo) + '&'; } if (targetWindow !== 'prefer-same-window' && checkWebView()) { targetWindow = 'prefer-same-window'; } if (targetWindow === 'prefer-popup') { lastPopup = NSLPopup(href + 'display=popup', 'nsl-social-connect', buttonLinkElement.dataset.popupwidth, buttonLinkElement.dataset.popupheight); if (lastPopup) { success = true; e.preventDefault(); } } else if (targetWindow === 'prefer-new-tab') { const newTab = window.open(href + 'display=popup', '_blank'); if (newTab) { if (window.focus) { newTab.focus(); } success = true; window._nslHasOpenedPopup = true; e.preventDefault(); } } if (!success) { window.location = href; e.preventDefault(); } } } } }); let buttonCountChanged = false; const googleLoginButtons = document.querySelectorAll(' a[data-plugin="nsl"][data-provider="google"]'); if (googleLoginButtons.length && checkWebView()) { googleLoginButtons.forEach(function (googleLoginButton) { if (scriptOptions._unsupportedWebviewBehavior === 'disable-button') { disableButtonInWebView(googleLoginButton); } else { googleLoginButton.remove(); buttonCountChanged = true; } }); } const facebookLoginButtons = document.querySelectorAll(' a[data-plugin="nsl"][data-provider="facebook"]'); if (facebookLoginButtons.length && checkWebView() && /Android/.test(window.navigator.userAgent) && !isAllowedWebViewForUserAgent('facebook')) { facebookLoginButtons.forEach(function (facebookLoginButton) { if (scriptOptions._unsupportedWebviewBehavior === 'disable-button') { disableButtonInWebView(facebookLoginButton); } else { facebookLoginButton.remove(); buttonCountChanged = true; } }); } const separators = document.querySelectorAll('div.nsl-separator'); if (buttonCountChanged && separators.length) { separators.forEach(function (separator) { const separatorParentNode = separator.parentNode; if (separatorParentNode) { const separatorButtonContainer = separatorParentNode.querySelector('div.nsl-container-buttons'); if (separatorButtonContainer && !separatorButtonContainer.hasChildNodes()) { separator.remove(); } } }) } });})();</script> </body> </html>