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Multimodal MR images can directly or indirectly help in identifying the substantia nigra, locus ceruleus, and raphe nuclei that contain monoamine neurons. Neuromelanin-sensitive magnetic resonance imaging can detect signal alterations in the substantia nigra pars compacta and/or locus ceruleus that occur in Parkinson's disease and psychiatric disorders such as depression and schizophrenia. 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{ return "ctl00_ctl29_g_300fb869_ef4b_49a4_a34e_a5196700ee6f_ctl00_emailToColleague"; }function image(id, nextImageId, previousImageId, title, description, rolloverUrl, popupUrl, fullSizeUrl, originalUrl, imageGalleryUrl, windowId){this.id = id;this.title = title;this.description = description;this.rolloverUrl = rolloverUrl;this.popupUrl = popupUrl;this.nextImageId = nextImageId;this.previousImageId = previousImageId; this.fullsizeUrl = fullSizeUrl; this.originalUrl = originalUrl;this.imageGalleryUrl = imageGalleryUrl; this.windowId=windowId}function Global_GetImagesCollection(){var images = new Object();images["T1-1"]=new image("T1-1","F1-1","","Table 1"," Monoaminergic nuclei in the brain stem","https://images.journals.lww.com/neuroreport/Rollover.00001756-200811190-00001.T1-1.jpeg","https://images.journals.lww.com/neuroreport/Gallery.00001756-200811190-00001.T1-1.jpeg","https://journals.lww.com/neuroreport/_layouts/oaks.journals/ImageView.aspx?k=neuroreport:2008:11190:00001&i=T1-1&year=2008&issue=11190&article=00001&type=Abstract","https://images.journals.lww.com/neuroreport/Original.00001756-200811190-00001.T1-1.jpeg","/neuroreport/pages/imagegallery.aspx?year=2008&issue=11190&article=00001", "neuroreport_2008_11190_00001_T1-1");images["F1-1"]=new image("F1-1","F2-1","T1-1","Fig. 1","Schematic drawing of the monoamine nuclei in the brain stem.","https://images.journals.lww.com/neuroreport/Rollover.00001756-200811190-00001.F1-1.jpeg","https://images.journals.lww.com/neuroreport/Gallery.00001756-200811190-00001.F1-1.jpeg","https://journals.lww.com/neuroreport/_layouts/oaks.journals/ImageView.aspx?k=neuroreport:2008:11190:00001&i=F1-1&year=2008&issue=11190&article=00001&type=Abstract","https://images.journals.lww.com/neuroreport/Original.00001756-200811190-00001.F1-1.jpeg","/neuroreport/pages/imagegallery.aspx?year=2008&issue=11190&article=00001", "neuroreport_2008_11190_00001_F1-1");images["F2-1"]=new image("F2-1","F3-1","F1-1","Fig. 2","Conventional magnetic resonance imaging of the substantia nigra in 40-year-old female volunteer. (a鈥揹) Axial sections at the level of the upper midbrain. (e鈥揾) Axial sections at the level of the lower midbrain. (i鈥搇) Coronal sections at the level of the red nucleus. (a and e) Myelin-stained microscopic specimens. (i) Macroscopic specimen. (b, f, j) Proton-density weighted images (PDWIs) at 1.5T. (c, g, k) T2-weighted images (T2WIs) at 1.5T. (d, h, l) T2WIs at 3T. On PDWIs at 1.5T, the substantia nigra is depicted as a gray matter signal area at the level of the upper as well as lower midbrain (b, f, j). On T2WIs at 1.5T, a hypointensity area is mainly distributed not at the substantia nigra but at the medial part of the peduncular fibers (c, g, k). On T2WIs at 3T, the area that corresponds with the substantia nigra becomes marked hypointensity in addition to the peduncular fibers (d, h, l). D, decussation of the superior cerebellar peduncle; I, inferior colliculus; N, substantia nigra; P, peduncular fibers; R, red nucleus; S, superior colliculus. Dotted lines indicate estimated boundary between the substantia nigra and peduncular fibers.","https://images.journals.lww.com/neuroreport/Rollover.00001756-200811190-00001.F2-1.jpeg","https://images.journals.lww.com/neuroreport/Gallery.00001756-200811190-00001.F2-1.jpeg","https://journals.lww.com/neuroreport/_layouts/oaks.journals/ImageView.aspx?k=neuroreport:2008:11190:00001&i=F2-1&year=2008&issue=11190&article=00001&type=Abstract","https://images.journals.lww.com/neuroreport/Original.00001756-200811190-00001.F2-1.jpeg","/neuroreport/pages/imagegallery.aspx?year=2008&issue=11190&article=00001", "neuroreport_2008_11190_00001_F2-1");images["F3-1"]=new image("F3-1","F4-1","F2-1","Fig. 3","Neuromelanin-sensitive magnetic resonance imaging of the substantia nigra and locus ceruleus. (a鈥揷) Axial sections at the level of the lower midbrain. (d鈥揻) Axial sections at the level of the upper pons. (a and d) Macroscopic specimens. (b and e) Neuromelanin-sensitive MR images of the healthy individual (64-year-old woman). (c and f) Neuromelanin-sensitive MR images of the patient with Parkinson\'s disease (PD) (65-year-old woman). On neuromelanin-sensitive MR images of the healthy subject, marked hyperintensity areas are visualized (b, e: arrows) at locations corresponding with the substantia nigra pars compacta (SNc) and locus ceruleus (LC) in the specimens (a, d: arrows). On images of the PD patient, signal intensity of these areas is diminished (c, f: arrows) as compared with that in the healthy control, suggesting degeneration of the SNc and LC.","https://images.journals.lww.com/neuroreport/Rollover.00001756-200811190-00001.F3-1.jpeg","https://images.journals.lww.com/neuroreport/Gallery.00001756-200811190-00001.F3-1.jpeg","https://journals.lww.com/neuroreport/_layouts/oaks.journals/ImageView.aspx?k=neuroreport:2008:11190:00001&i=F3-1&year=2008&issue=11190&article=00001&type=Abstract","https://images.journals.lww.com/neuroreport/Original.00001756-200811190-00001.F3-1.jpeg","/neuroreport/pages/imagegallery.aspx?year=2008&issue=11190&article=00001", "neuroreport_2008_11190_00001_F3-1");images["F4-1"]=new image("F4-1","F5-1","F3-1","Fig. 4","Short inversion-time inversion recovery (STIR) images of the raphe nuclei. Axial sections at the levels of the lower midbrain (a), upper pons (b), and pontomedullary junction (c). Locations of the dorsal raphe nucleus (dr), central superior nucleus (cs), and raphe magnus nucleus (rm) can be estimated as relatively bright areas at the midline zone of the brain stem tegmentum. Small arrow indicates medial longitudinal fasciculus.","https://images.journals.lww.com/neuroreport/Rollover.00001756-200811190-00001.F4-1.jpeg","https://images.journals.lww.com/neuroreport/Gallery.00001756-200811190-00001.F4-1.jpeg","https://journals.lww.com/neuroreport/_layouts/oaks.journals/ImageView.aspx?k=neuroreport:2008:11190:00001&i=F4-1&year=2008&issue=11190&article=00001&type=Abstract","https://images.journals.lww.com/neuroreport/Original.00001756-200811190-00001.F4-1.jpeg","/neuroreport/pages/imagegallery.aspx?year=2008&issue=11190&article=00001", "neuroreport_2008_11190_00001_F4-1");images["F5-1"]=new image("F5-1","","F4-1","Fig. 5","Neuromelanin-sensitive MR images of patients with psychiatric disorders. (a鈥揷) Axial sections at the level of the lower midbrain. (d鈥揻) Axial sections at the level of the upper pons. (a and d) Sections of healthy individual (38-year-old woman). (b and e) Sections of patient with depression (43-year-old man). (c and f) Sections of patient with schizophrenia (37-year-old woman). The signal of the locus ceruleus is reduced in the depressive patient (e; arrow) as compared with that in the control and the schizophrenic patient; whereas the signal in the substantia nigra pars compacta is increased in the schizophrenic patient (c; arrow) as compared with that in the control and the depressive patient.","https://images.journals.lww.com/neuroreport/Rollover.00001756-200811190-00001.F5-1.jpeg","https://images.journals.lww.com/neuroreport/Gallery.00001756-200811190-00001.F5-1.jpeg","https://journals.lww.com/neuroreport/_layouts/oaks.journals/ImageView.aspx?k=neuroreport:2008:11190:00001&i=F5-1&year=2008&issue=11190&article=00001&type=Abstract","https://images.journals.lww.com/neuroreport/Original.00001756-200811190-00001.F5-1.jpeg","/neuroreport/pages/imagegallery.aspx?year=2008&issue=11190&article=00001", "neuroreport_2008_11190_00001_F5-1"); return images; }function getPopupImageId() { return 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<div class="wk-button-group-left"> <p id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pUnsubscribeButtons" Style="display: none;"> <input type="submit" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$btnContinue" value="Yes" onclick="javascript:WebForm_DoPostBackWithOptions(new WebForm_PostBackOptions("ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$btnContinue", "", true, "", "", false, false))" id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_btnContinue" class="primary-button" /> <input type="button" value="No" id="btnCancel" aria-label="close dialog" class="js-close secondary-button" /> </p> </div> </div> </div> </div> </section> </div> </div> </div> </div> </div> <div id="ej-clear-float"> </div> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$hiddenUnSubscribeAlertType" id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnSubscribeAlertType" /> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$hiddenUnsubscribeJournalId" id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeJournalId" /> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$hiddenUnsubscribeMessage" id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeMessage" /> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$hiddenTopicalCollectionId" id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenTopicalCollectionId" /> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$hiddenOvidId" id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenOvidId" /> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$hiddenJournalId" id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId" /> <script type="text/javascript"> function alerts_ShowUnSubscribeeTOCPopup(title, alertType, journalId) { var unSubscribeeTocPopup = $find('unSubscribeToAlerts'); var lblUnsubscribeMessage = document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_lblUnsubscribeMessage'); lblUnsubscribeMessage.innerHTML = title; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnSubscribeAlertType').value = alertType; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeMessage').value = title; $('#' + 'ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pUnsubscribeButtons').show(); if (document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value == null || document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value == '') { document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value = journalId; } if (unSubscribeeTocPopup != null) { unSubscribeeTocPopup.show(); } } function alerts_ShowUnSubscribeeTOCPopup_Root(title, journalId, alertType) { var unSubscribeeTocPopup = $find('unSubscribeToAlerts'); var lblUnsubscribeMessage = document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_lblUnsubscribeMessage'); lblUnsubscribeMessage.innerHTML = title; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeMessage').value = title; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnSubscribeAlertType').value = alertType; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeJournalId').value = journalId; $('#' + 'ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pUnsubscribeButtons').show(); if (unSubscribeeTocPopup != null) { unSubscribeeTocPopup.show(); } } function alerts_ShowUnSubscribeeTOCPopup_Citation(title, journalId, ovidId) { var unSubscribeeTocPopup = $find('unSubscribeToAlerts'); var lblUnsubscribeMessage = document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_lblUnsubscribeMessage'); lblUnsubscribeMessage.innerHTML = title; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeMessage').value = title; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnSubscribeAlertType').value = 'Citation'; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeJournalId').value = journalId; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenOvidId').value = ovidId; $('#' + 'ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pUnsubscribeButtons').show(); if (unSubscribeeTocPopup != null) { unSubscribeeTocPopup.show(); } } function alerts_ShowUnSubscribeeTOCPopup_Topical(title, journalId, topicalCollectionId) { var unSubscribeeTocPopup = $find('unSubscribeToAlerts'); var lblUnsubscribeMessage = document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_lblUnsubscribeMessage'); lblUnsubscribeMessage.innerHTML = title; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeMessage').value = title; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnSubscribeAlertType').value = 'Topical'; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeJournalId').value = journalId; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenTopicalCollectionId').value = topicalCollectionId; $('#' + 'ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pUnsubscribeButtons').show(); if (document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value == null || document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value == '') { document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value = journalId; } if (unSubscribeeTocPopup != null) { unSubscribeeTocPopup.show(); } } function alerts_ShowUnSubscribeeTOCSuccessPopup() { var unSubscribeeTocPopup = $find('unSubscribeToAlerts'); if (unSubscribeeTocPopup != null) { unSubscribeeTocPopup.show(); } } $('.js-close').on('click', function() { var unSubscribeeTocPopup = $find('unSubscribeToAlerts'); if (unSubscribeeTocPopup != null) { unSubscribeeTocPopup.hide(); } return false; }); </script> <span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_dummyTargetControl"></span> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$hiddenSubscribeToEtocPopupState" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenSubscribeToEtocPopupState" value="showemail" /> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$hiddenConfirmSubscriptionPageUrl" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenConfirmSubscriptionPageUrl" /> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$hiddenJournalId" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenJournalId" /> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$hiddenSubscriptionType" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenSubscriptionType" /> <div id="divPopupOverLay" class="Popup-Overlay" style="display: none; position: fixed; left: 0; top: 0; z-index: 3800; width: 1920px; height: 4517px;"></div> <div id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlSubscribeToEtoc" class="etoc-popup ej-box-modal-drop-shadow" style="display: none;"> <div tabindex="-1" role="dialog" class="wk-modal horizontally-centered small wk-modal-with-overlay wk-modal-small ejp-modal"> <div id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlMain" onkeypress="javascript:return WebForm_FireDefaultButton(event, 'ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_btnContinue')"> <section class="wk-modal-content"> <header class="wk-modal-header ejp-modal-header"> <div class="wk-modal-title ejp-modal-title"> <span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblTitle"></span> </div> <button aria-label="close dialog" class="js-close primary-button wk-button-icon wk-modal-close ejp-modal-close "> <i class="fa fa-times"></i> </button> </header> <div class="wk-modal-body"> <div class="wk-field-item"> <div class="wk-field-body"> <strong> <span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblThankYouMessage"></span></strong> </div> <div class="wk-field-body"> <span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_cvEmailError" style="color:Black;display:none;"> <div class="ej-error-message"> <p class="ej-error-message-icon error-red"> </p> </div> </span> <label for="Email input">Enter your Email address:</label> <div class="wk-field-body"> <input name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$txtEmailAddress" type="text" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_txtEmailAddress" class="ej-box-modal-style-1-input" /> </div> </div> <div class="wk-button-bar"> <div class="wk-button-group-left"> <input type="submit" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$btnContinue" value="Continue" onclick="javascript:WebForm_DoPostBackWithOptions(new WebForm_PostBackOptions("ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$btnContinue", "", true, "", "", false, false))" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_btnContinue" class="primary-button" /> <input type="button" value="Cancel" id="btnCancel" class="js-close secondary-button" /> </div> </div> </div> <div class="wk-field-item"> <div class="wk-field-body"> <a id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hypPrivacy" href="https://journals.lww.com/neuroreport/_layouts/oaks.journals/privacy.aspx" target="_blank">Privacy Policy</a> </div> </div> </div> </section> </div> <div id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlAuthenticatedUser" style="display: none;"> <section class="wk-modal-content"> <header class="wk-modal-header ejp-modal-header"> <div class="wk-modal-title ejp-modal-title"></div> <button aria-label="close dialog" class="js-close primary-button wk-button-icon wk-modal-close ejp-modal-close "><i class="fa fa-times"></i></button> </header> <div class="wk-modal-body"> <div class="wk-field-item"> <p> <strong> <span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblAuthenticatedUserTitle"></span> </strong> </p> </div> <p id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pAuthenticatedUserMessage"> </p> </div> </section> </div> </div> </div> <div id="ej-clear-float"> </div> <script type="text/javascript"> function alerts_SaveSubscriptionTypeInHiddenField(url, subscriptionType, journalId, yearId, issueId, articleId) { if (journalId && yearId && issueId && articleId) { logCounterDataAlertWhenCitedSynchronously(journalId, yearId, issueId, articleId); } $('#' + 'ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenSubscriptionType').val(subscriptionType); $('#' + 'ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenJournalId').val(journalId); if (url) window.location = url; else __doPostBack('hypSubscribeToAlerts'); return false; } function alerts_ShowSubscribeeTOCPopup(journalTitle, journalId, subscriptionType, displaySubscriptionType) { $('#' + 'ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenSubscriptionType').val(subscriptionType); var subscribeToEtocPopup = $find('subscribeToEtoc'); subscribeToEtocPopup.show(); document.getElementsByTagName( 'html' )[0].classList.add('no-scroll'); var modelPopupState = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenSubscribeToEtocPopupState'); var emailTextBox = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_txtEmailAddress'); var thanksPanel = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlAuthenticatedUser'); var mainPanel = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlMain'); var thankYouMessageUnAuthenticated = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblThankYouMessage'); var thankYouMessageAuthenticated = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblAuthenticatedUserTitle'); if (!displaySubscriptionType) { displaySubscriptionType = subscriptionType; } if (modelPopupState.value == 'showthanksmessage') { thanksPanel.style.display = "block"; mainPanel.style.display = "none"; thankYouMessageAuthenticated.innerHTML = "Thank you for subscribing to the " + displaySubscriptionType + " for " + journalTitle + "."; } if (modelPopupState.value == 'showemail') { thanksPanel.style.display = "none"; mainPanel.style.display = "block"; thankYouMessageUnAuthenticated.innerHTML = "Thank you for choosing to subscribe to the " + displaySubscriptionType + " for " + journalTitle + "."; } if ($('.etoc-popup') != null) { document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenJournalId').value = journalId; if (modelPopupState.value == 'showemail') emailTextBox.focus(); } } $('.js-close').on('click', function () { document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_txtEmailAddress').value = ""; document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_cvEmailError').style.display = "none"; var pageUrl = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenConfirmSubscriptionPageUrl'); var subscribeeTocPopup = $find('subscribeToEtoc'); if (subscribeeTocPopup != null) { subscribeeTocPopup.hide(); document.getElementsByTagName( 'html' )[0].classList.remove('no-scroll'); if (pageUrl.value !== '' && pageUrl.value !== window.location.pathname) window.location = pageUrl.value; } return false; }); </script> <div id="ctl00_ctl51_Header_UserActionTools_eTocTopContainer"> <div id="eTocTop" style="display: none;"> <a rel="nofollow" title href="javascript:javascript: alerts_ShowSubscribeeTOCPopup('NeuroReport','neuroreport','eTOC', 'eTOC');;" onclick="javascript: alerts_ShowSubscribeeTOCPopup('NeuroReport','neuroreport','eTOC', 'eTOC');"><span id="ctl00_ctl51_Header_UserActionTools_alertLinkControlTop_defaultText" class="hideOnFixed">Subscribe to eTOC</span></a> </div> </div> <script> $(function () { //find recent searches link and move container var recentSearchesControl = $("a[id$='RecentSearches']"); if (recentSearchesControl.length) { recentSearchesControl.click(function (e) { e.stopPropagation(); if ($("#ResentSearchContainer").is(":hidden")) { $("#ResentSearchContainer").slideDown("slow"); recentSearchesControl.addClass('open'); } else { $("#ResentSearchContainer").hide(); recentSearchesControl.removeClass('open'); } }); } var eTocAccountLink = $("ul.js-user-action-toolbar__dropdown>li>a[id='SubscribeToEToc']"); if (eTocAccountLink.length) { eTocAccountLink.parent().html($("#eTocTop>a")); } }); </script> <a class="logo-secondary" href="" target="_blank"> <h3 class="logo-secondary-text">Secondary Logo</h3> </a> <a href="#" class="sticky-search"><i class="fa fa-search"></i></a> </div> <div class="header__layout-bottom wk-grid-page-container"> <a id="hypJournals" class="logo-main" href="https://journals.lww.com/neuroreport/pages/default.aspx"> <h3 class="logo-main-text">Journal Logo </h3> </a> <div class="search-v2"> <div class="search-wrapper"> <select name="ctl00$ctl51$Header$SearchTopBoxControl$ddlContentScope" id="ctl00_ctl51_Header_SearchTopBoxControl_ddlContentScope"> <option value="All">All</option> <option selected="selected" value="Articles">Articles</option> <option value="Images">Images</option> <option value="Videos">Videos</option> <option value="Podcasts">Podcasts</option> <option value="Blogs">Blogs</option> </select> <div class="input-group" id="globalSearch"> <input name="ctl00$ctl51$Header$SearchTopBoxControl$txtKeywords" type="text" value="Search" id="ctl00_ctl51_Header_SearchTopBoxControl_txtKeywords" class="form-control searchText" /> <span class="input-group-btn"> <button id="ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearchMagnifier" type="submit" class="btn btn-default"><i class="fa fa-search"></i></button> </span> <input type="hidden" name="ctl00$ctl51$Header$SearchTopBoxControl$IsAutoCompleteEnabled" id="ctl00_ctl51_Header_SearchTopBoxControl_IsAutoCompleteEnabled" value="true" /> <input type="hidden" name="ctl00$ctl51$Header$SearchTopBoxControl$AutocompleteApiUrl" id="ctl00_ctl51_Header_SearchTopBoxControl_AutocompleteApiUrl" value="https://platformservices.wolterskluwerhealth.com/autocomplete/NEREP/shingle/" /> </div> </div> <div class="advance-search" style=""> <a id="ctl00_ctl51_Header_SearchTopBoxControl_lnkAdvanceSearch" href="https://journals.lww.com/neuroreport/pages/advancedsearch.aspx">Advanced Search</a> <input type="submit" name="ctl00$ctl51$Header$SearchTopBoxControl$btnGlobalSearch" value="" id="ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearch" disabled="disabled" class="aspNetDisabled btnGlobalSearch" style="display: none;" /> <input name="ctl00$ctl51$Header$SearchTopBoxControl$hfldKeywords" type="hidden" id="ctl00_ctl51_Header_SearchTopBoxControl_hfldKeywords" class="hfldKeywords" value="disableButton" /> </div> </div> <script> $(function() { try { var objSearchBox = { btnGlobalSearchMagnifierId: 'ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearchMagnifier', searchButtonId: 'ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearch', txtKeywordsId: 'ctl00_ctl51_Header_SearchTopBoxControl_txtKeywords', hfldKeywordsHiddenId: 'ctl00_ctl51_Header_SearchTopBoxControl_hfldKeywords', defaultSearchText: 'Search' }; new Searchbox(objSearchBox).Init(); } catch (e) { console.error(e); } }); //autocomplete functionality for basic search //this functionality will call the SBA url and start suggesting after typing 3rd character var textKeywords = null; var hiddenAutocompleteApiUrl = null; var buttonGlobalSearch = null; $(function () { try { var objAutocomplete = { hiddenIsAutoCompleteEnabled: $('#ctl00_ctl51_Header_SearchTopBoxControl_IsAutoCompleteEnabled'), textKeywords: $('#ctl00_ctl51_Header_SearchTopBoxControl_txtKeywords'), hiddenAutocompleteApiUrl: $('#ctl00_ctl51_Header_SearchTopBoxControl_AutocompleteApiUrl'), buttonGlobalSearch: $('#ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearch'), enableNewAutoComplete: true, newAutoCompleteUrl: 'https://dxg-search-na-prd.wkgposvc.cloud/Query.svc/Query_Expand', newAutoCompleteMaxSuggestions: '10', newAutoCompleteDictionaryIds: 'ovid_sted28_mesh22' }; autoComplete(objAutocomplete); } catch (e) { console.error(e); } }); $(function () { let searchSelect = $('select[id$="ddlContentScope"]');; if (searchSelect.length){ searchSelect.selectize(); } }); </script> </div> <div id="main-nav-container-v2"> <nav id="main-nav" class="navbar navbar-default yamm wk-grid-page-container"> <div class="navbar-header"> <button id="fatJuicy" type="button" class="navbar-hamburger-button navbar-toggle collapsed pull-left" data-bs-toggle="collapse" data-bs-target="#zz1_TopNavigationMenu" aria-expanded="false" aria-controls="navbar"> <span class="visually-hidden">Toggle navigation</span> <span class="icon-bar"></span> <span class="icon-bar"></span> <span class="icon-bar"></span> <span class="navbar-hamburger-button__text"></span> </button> </div> <div id="navActionButtons" class="btn-group navbar-hover-color" role="group" aria-label="..."> <a id="ctl00_ctl51_lnkSubscribe" class="btn btn-default navbar-button" href="https://shop.lww.com/p/0959-4965" target="_blank">Subscribe</a> <a id="ctl00_ctl51_lnkRegister" class="btn btn-default navbar-button" href="https://journals.lww.com/neuroreport/pages/register.aspx?ContextUrl=%2fneuroreport%2fabstract%2f2008%2f11190%2fmonoamine_neurons_in_the_human_brain_stem_.1.aspx">Register</a> <button class="user-menu__link user-menu__link--login js-ejp-login-btn btn btn-default navbar-button" type="button" data-config="{"eventName":"login","eventDetail":{},"isNull":false}"> <span>Login</span> </button> </div> <div id="ctl00_ctl51_TopNavigationMenuConfiguration" style="display:none" class="js-top-navigation-menu-configuration" data-config="{"browsingHistory":{"isEnabled":true,"serviceUrl":"https://apim-hlrp-ejp-prod.azure-api.net/ee","pdfDownloadUrl":"/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=HistoryTab"}}"></div> <div id="zz1_TopNavigationMenu" class="navbar-collapse collapse js-top-navigation-menu noindex ms-core-listMenu-horizontalBox"> <ul id="zz2_RootAspMenu" class="root ms-core-listMenu-root static"> <li class="static dynamic-children"><span class="static dynamic-children menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode"><span aria-haspopup="true" class="additional-background ms-navedit-flyoutArrow dynamic-children"><span class="menu-item-text">Articles & Issues</span></span></span><ul aria-hidden="true" class="dynamic"> <li class="dynamic"><a class="dynamic menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode" href="/neuroreport/Pages/currenttoc.aspx" accesskey="1"><span class="additional-background 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'Monoamine neurons in the human brain stem: anatomy, magnetic resonance imaging findings, and clinical implications', '11192008', 'Makoto Sasaki, Eri Shibata, Koujiro Tohyama, et al', '19', '17', '\u00A9 2008 Lippincott Williams & Wilkins, Inc.', '00001756-200811190-00001', '', false, ''); } </script> <div id="ArticleContainer"> <article id="ej-abstract-view" xmlns:ssr="http://ssr-eus-go-csi.cloudapp.net/v1/assets" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xhtml="http://www.w3.org/1999/xhtml"><section class="ejp-r-article-subsection"><div class="ejp-r-article-subsection__text">REVIEW</div></section><header class="ejp-article-header"><h1 class="ejp-article-title">Monoamine neurons in the human brain stem: anatomy, magnetic resonance imaging findings, and clinical implications</h1></header><section id="ejp-article-authors"><p id="P7">Sasaki, Makoto<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">a</sup>; Shibata, Eri<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">a b</sup>; Tohyama, Koujiro<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">c</sup>; Kudo, Kohsuke<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">a</sup>; Endoh, Jin<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">b</sup>; Otsuka, Kotaro<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">b</sup>; Sakai, Akio<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">b</sup></p><section><a href="#" id="ejp-article-authors-link"> Author Information <i class="wk-icon-arrow-down-r"></i></a></section></section><section id="ejp-article-authors-info" class="ejp-article-authors-info ejp-article-authors-info--hidden"><div class="ejp-article-authors-info-holder"> <p id="AF_ID_d7e78"><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">a</sup>Advanced Medical Research Center</p> <p id="AF_ID_d7e78"><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">b</sup>Department of Neuropsychiatry</p> <p id="AF_ID_d7e78"><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">c</sup>Center for EM and Bio-Imaging Research, Iwate Medical University, Uchimaru, Morioka, Japan</p> <p id="BT_ID_d7e99">Correspondence to Makoto Sasaki, MD, Advanced Medical Research Center, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, Japan</p> <p id="BT_ID_d7e99">Tel: +81 19 651 5111; fax: +81 19 622 1091; e-mail: <span><a href="/cdn-cgi/l/email-protection#c0ada1b3a1b3a1aba980a9b7a1b4a5edada5a4eea1a3eeaab0" onclick="javascript:window.open('mailto:masasaki@iwate-med.ac.jp');return false"><span class="__cf_email__" data-cfemail="ed808c9e8c9e8c8684ad849a8c9988c0808889c38c8ec3879d">[email protected]</span></a></span></p> <p id="BT_ID_d7e99">Received 18 August 2008; accepted 18 August 2008</p> </div></section><section id="article-journal-info"><div class="ej-journal-info"><span class="ej-journal-name">NeuroReport </span><span id="ej-journal-date-volume-issue-pg"><a href="/neuroreport/toc/2008/11190">19(17):p 1649-1654, November 19, 2008.</a></span><span> | </span><span class="ej-journal-doi">DOI: </span>10.1097/WNR.0b013e328315a637</div></section><section id="ejp-article-indicators" class="ejp-article-indicators"><ul class="ejp-article-indicators__list"> <li id="ej-article-indicators-buy" class="ejp-article-indicators__list-item" onmouseover="javascript:Tooltip_Buy()" onmouseout="javascript:Tooltip_MouseOut()"><a href="#ContentAccessOptions"><span class="ejp-indicator">Buy</span></a></li> </ul><button id="openArticleMetricsPopupButton" type="button" class="wk-button wk-button-ghost wk-button-icon-left ejp-article-metrics-btn" data-articleMetricsEndpoint="//services.journals.lww.com/IntegrationServices/ArticleMetricsService.svc" data-articleMetricsDetailsUrl="https://wolterskluwer.altmetric.com/details/" data-doi="10.1097/WNR.0b013e328315a637" data-suiteId="vrs_woltere_journalsglobalvrs" data-articlePublicationDate="2008-11-19" data-articlePublicationDateString="November 19, 2008" data-receivedDate="" data-revisionReceivedDate="" data-acceptedDate="" data-crossrefRefLinkRoot="https://doi.org/" data-medlineRefLinkRoot="http://www.ncbi.nlm.nih.gov/pubmed/" data-pubMedId=""><i class="wk-icon-filled-chart-r"></i><i class="wk-icon-filled-chart-white-r"></i> Metrics </button></section><section class="ejp-article-tabs" id="abstractWrap"><h2 class="ejp-article-tabs-heading">Abstract</h2> <div class="ejp-article-tabs__tabpanel" id="panel1" role="tabpanel" aria-labelledby="tab1"> <div id="article-abstract-content1"> <div class="ejp-article-text-abstract"> <p>By using high-resolution, conventional, and neuromelanin-sensitive magnetic resonance imaging techniques, we reviewed the normal anatomy of the nuclei consisting of monoamine neurons such as dopaminergic, noradrenergic, and serotoninergic neurons and noted the changes in these nuclei that occur in some degenerative and psychiatric disorders. Multimodal MR images can directly or indirectly help in identifying the substantia nigra, locus ceruleus, and raphe nuclei that contain monoamine neurons. Neuromelanin-sensitive magnetic resonance imaging can detect signal alterations in the substantia nigra pars compacta and/or locus ceruleus that occur in Parkinson's disease and psychiatric disorders such as depression and schizophrenia. This technique seems to be promising for the noninvasive evaluation of the pathological or functional changes in the monoamine system that occur in degenerative and psychiatric disorders.</p> </div> </div> </div></section><section class="ej-article-copyright">漏 2008 Lippincott Williams & Wilkins, Inc.</section></article> </div> </div> <section id="ContentAccessOptions" class="article-not-authorized-msg"> <div class="ejp-access-options-wrapper"> <div class="ejp-access-options ejp-access-options--desktop"> <div id="ctl00_ctl29_g_300fb869_ef4b_49a4_a34e_a5196700ee6f_ctl00_FullTextAccessOptionsContainer" class="ejp-access-options__subscriber-access"> <h3 class="ejp-access-options__subscriber-access-title">Full Text Access for Subscribers:</h3> <div class="ejp-access-options__subscriber-access-society-list"> <div id="ctl00_ctl29_g_300fb869_ef4b_49a4_a34e_a5196700ee6f_ctl00_PrimaryLoginBox" class="box-ssologin primary-login-box"> <a 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