CINXE.COM

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id="pathways_development_pathways" action="/pathways/developmental-biology" method="post"> <a href="/pathways/developmental-biology" data-form="pathways_development_pathways" class="pathway_link"> <span class="icon-"> Development Pathways </span> </a> <input type="hidden" name="pw_parent" value="developmental-biology"> </form> </li> <li class="pathways-li "> <form id="pathways_glycobiology_pathways" action="/pathways/glycobiology" method="post"> <a href="/pathways/glycobiology" data-form="pathways_glycobiology_pathways" class="pathway_link"> <span class="icon-"> Glycobiology Pathways </span> </a> <input type="hidden" name="pw_parent" value="Glycobiology"> </form> </li> <li class="pathways-li active"> <form id="pathways_immunology_pathways" action="/pathways/immunology" method="post"> <a href="/pathways/immunology" data-form="pathways_immunology_pathways" class="pathway_link"> <span class="icon-"> Immunology Pathways </span> </a> <input type="hidden" name="pw_parent" value="Immunology"> </form> <ul> <form id="pathways_adipokines__insulin_signaling_pathways" action="/pathways/adipokines-insulin-signaling-pathways" method="post"> <li class=""> <a href="/pathways/adipokines-insulin-signaling-pathways" class="pathway_link" data-form="pathways_adipokines__insulin_signaling_pathways"> Adipokines & Insulin Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_apoptosis_signaling_pathway" action="/pathways/apoptosis-signaling-pathway" method="post"> <li class=""> <a href="/pathways/apoptosis-signaling-pathway" class="pathway_link" data-form="pathways_apoptosis_signaling_pathway"> Apoptosis Signaling Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_b_cell_development_pathways" action="/pathways/b-cell-development-pathways" method="post"> <li class=""> <a href="/pathways/b-cell-development-pathways" class="pathway_link" data-form="pathways_b_cell_development_pathways"> B Cell Development Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_blood_coagulation_signaling_pathways" action="/pathways/blood-coagulation-signaling-pathways" method="post"> <li class=""> <a href="/pathways/blood-coagulation-signaling-pathways" class="pathway_link" data-form="pathways_blood_coagulation_signaling_pathways"> Blood Coagulation Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_cardiotrophin-1_signaling_pathways" action="/pathways/cardiotrophin-signaling-pathways" method="post"> <li class=""> <a href="/pathways/cardiotrophin-signaling-pathways" class="pathway_link" data-form="pathways_cardiotrophin-1_signaling_pathways"> Cardiotrophin-1 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_cardiotrophin-like_cytokine_clc_signaling_pathways" action="/pathways/cardiotrophin-cytokine-clc-signaling-pathways" method="post"> <li class=""> <a href="/pathways/cardiotrophin-cytokine-clc-signaling-pathways" class="pathway_link" data-form="pathways_cardiotrophin-like_cytokine_clc_signaling_pathways"> Cardiotrophin-like Cytokine CLC Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_chemokine_signaling_pathways" action="/pathways/chemokine-signaling-pathways" method="post"> <li class=""> <a href="/pathways/chemokine-signaling-pathways" class="pathway_link" data-form="pathways_chemokine_signaling_pathways"> Chemokine Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_chemokine_superfamily_pathway__human_mouse_ligand-receptor_interactions" action="/pathways/chemokine-superfamily-pathway-human-mouse-lig-recept-interactions" method="post"> <li class=""> <a href="/pathways/chemokine-superfamily-pathway-human-mouse-lig-recept-interactions" class="pathway_link" data-form="pathways_chemokine_superfamily_pathway__human_mouse_ligand-receptor_interactions"> Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_cntf_signaling_pathways" action="/pathways/cntf-signaling-pathways" method="post"> <li class=""> <a href="/pathways/cntf-signaling-pathways" class="pathway_link" data-form="pathways_cntf_signaling_pathways"> CNTF Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_common_cytokine_receptor_gamma-chain_family_signaling_pathways" action="/pathways/common-cytokine-receptor-gamma-chain-family-signaling-pathways" method="post"> <li class=""> <a href="/pathways/common-cytokine-receptor-gamma-chain-family-signaling-pathways" class="pathway_link" data-form="pathways_common_cytokine_receptor_gamma-chain_family_signaling_pathways"> Common Cytokine Receptor Gamma-Chain Family Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_dendritic_cell_lineage_development_pathways" action="/pathways/dendritic-cell-lineage-development-pathways" method="post"> <li class=""> <a href="/pathways/dendritic-cell-lineage-development-pathways" class="pathway_link" data-form="pathways_dendritic_cell_lineage_development_pathways"> Dendritic Cell Lineage Development Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_fgf_family_signaling_pathways" action="/pathways/fgf-signaling-pathways" method="post"> <li class=""> <a href="/pathways/fgf-signaling-pathways" class="pathway_link" data-form="pathways_fgf_family_signaling_pathways"> FGF Family Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_iga-producing_b_cells_in_the_intestine" action="/pathways/iga-producing-b-cells-in-the-intestine" method="post"> <li class=""> <a href="/pathways/iga-producing-b-cells-in-the-intestine" class="pathway_link" data-form="pathways_iga-producing_b_cells_in_the_intestine"> IgA-Producing B Cells in the Intestine </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-1_family_signaling_pathways" action="/pathways/il-1-family-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-1-family-signaling-pathways" class="pathway_link" data-form="pathways_il-1_family_signaling_pathways"> IL-1 Family Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-10_cytokine_family_signaling_pathway" action="/pathways/il-10-cytokine-family-signaling-pathway" method="post"> <li class=""> <a href="/pathways/il-10-cytokine-family-signaling-pathway" class="pathway_link" data-form="pathways_il-10_cytokine_family_signaling_pathway"> IL-10 Cytokine Family Signaling Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-11_signaling_pathways" action="/pathways/il-11-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-11-signaling-pathways" class="pathway_link" data-form="pathways_il-11_signaling_pathways"> IL-11 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-12_family_signaling_pathways" action="/pathways/il-12-family-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-12-family-signaling-pathways" class="pathway_link" data-form="pathways_il-12_family_signaling_pathways"> IL-12 Family Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-15_signaling_pathways" action="/pathways/il15-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il15-signaling-pathways" class="pathway_link" data-form="pathways_il-15_signaling_pathways"> IL-15 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-15_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-15-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-15-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-15_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-17_family_signaling_pathways" action="/pathways/il17-family-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il17-family-signaling-pathways" class="pathway_link" data-form="pathways_il-17_family_signaling_pathways"> IL-17 Family Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-2_signaling_pathways" action="/pathways/il2-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il2-signaling-pathways" class="pathway_link" data-form="pathways_il-2_signaling_pathways"> IL-2 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-2_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-2-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-2-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-2_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-2 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-21_signaling_pathways" action="/pathways/il21-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il21-signaling-pathways" class="pathway_link" data-form="pathways_il-21_signaling_pathways"> IL-21 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-21_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-21-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-21-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-21_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-27_p28_il-30_signaling_pathways" action="/pathways/il-27-p28il-30-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-27-p28il-30-signaling-pathways" class="pathway_link" data-form="pathways_il-27_p28_il-30_signaling_pathways"> IL-27 p28/IL-30 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-31_signaling_pathways" action="/pathways/il-31-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-31-signaling-pathways" class="pathway_link" data-form="pathways_il-31_signaling_pathways"> IL-31 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-4_signaling_pathways" action="/pathways/il4-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il4-signaling-pathways" class="pathway_link" data-form="pathways_il-4_signaling_pathways"> IL-4 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-4_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-4-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-4-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-4_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-6_signaling_pathways" action="/pathways/il-6-family-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-6-family-signaling-pathways" class="pathway_link" data-form="pathways_il-6_signaling_pathways"> IL-6 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-7_signaling_pathways" action="/pathways/il7-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il7-signaling-pathways" class="pathway_link" data-form="pathways_il-7_signaling_pathways"> IL-7 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-7_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-7-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-7-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-7_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-7 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-9_signaling_pathways" action="/pathways/il9-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il9-signaling-pathways" class="pathway_link" data-form="pathways_il-9_signaling_pathways"> IL-9 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-9_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-9-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-9-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-9_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_inflammasome_activation_pathways" action="/pathways/inflammasome-activation-pathways" method="post"> <li class=""> <a href="/pathways/inflammasome-activation-pathways" class="pathway_link" data-form="pathways_inflammasome_activation_pathways"> Inflammasome Activation Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_innate_lymphoid_cell_differentiation_pathways" action="/pathways/innate-lymphoid-cell-differentiation-pathways" method="post"> <li class=""> <a href="/pathways/innate-lymphoid-cell-differentiation-pathways" class="pathway_link" data-form="pathways_innate_lymphoid_cell_differentiation_pathways"> Innate Lymphoid Cell Differentiation Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_lif_signaling_pathways" action="/pathways/lif-signaling-pathways" method="post"> <li class=""> <a href="/pathways/lif-signaling-pathways" class="pathway_link" data-form="pathways_lif_signaling_pathways"> LIF Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mdsc-mediated_mechanisms_of_immunosuppression" action="/pathways/mdsc-mediated-mechanisms-of-immunosuppression" method="post"> <li class=""> <a href="/pathways/mdsc-mediated-mechanisms-of-immunosuppression" class="pathway_link" data-form="pathways_mdsc-mediated_mechanisms_of_immunosuppression"> MDSC-Mediated Mechanisms of Immunosuppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mechanisms_of_regulatory_t_cell-mediated_suppression" action="/pathways/mechanisms-of-regulatory-t-cell-mediated-suppression" method="post"> <li class=""> <a href="/pathways/mechanisms-of-regulatory-t-cell-mediated-suppression" class="pathway_link" data-form="pathways_mechanisms_of_regulatory_t_cell-mediated_suppression"> Mechanisms of Regulatory T Cell-Mediated Suppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mechanisms_of_tumor-associated_macrophage_tam-mediated_immunosuppression" action="/pathways/tumor-associated-macrophage-tam" method="post"> <li class=""> <a href="/pathways/tumor-associated-macrophage-tam" class="pathway_link" data-form="pathways_mechanisms_of_tumor-associated_macrophage_tam-mediated_immunosuppression"> Mechanisms of Tumor-Associated Macrophage TAM-Mediated Immunosuppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mechanisms_of_tumor-derived_exosome_tex-mediated_immunosuppression" action="/pathways/mechanisms-tumor-derived-exosome-tex-mediated-immunosuppression" method="post"> <li class=""> <a href="/pathways/mechanisms-tumor-derived-exosome-tex-mediated-immunosuppression" class="pathway_link" data-form="pathways_mechanisms_of_tumor-derived_exosome_tex-mediated_immunosuppression"> Mechanisms of Tumor-derived Exosome TEX-mediated Immunosuppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_natural_killer_cell_receptors__human_target_cell_–_nk_cell_ligand-receptor_interactions" action="/pathways/natural-killer-cell-receptors-human-target-cell-nk-cell-ligand-receptor-interactions-pathway" method="post"> <li class=""> <a href="/pathways/natural-killer-cell-receptors-human-target-cell-nk-cell-ligand-receptor-interactions-pathway" class="pathway_link" data-form="pathways_natural_killer_cell_receptors__human_target_cell_–_nk_cell_ligand-receptor_interactions"> Natural Killer Cell Receptors: Human Target Cell – NK Cell Ligand-Receptor Interactions </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_neuropoietin_signaling_pathways" action="/pathways/neuropoietin-signaling-pathways" method="post"> <li class=""> <a href="/pathways/neuropoietin-signaling-pathways" class="pathway_link" data-form="pathways_neuropoietin_signaling_pathways"> Neuropoietin Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_nod-like_receptor_signaling_pathways" action="/pathways/nod-like-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/nod-like-receptor-signaling-pathways" class="pathway_link" data-form="pathways_nod-like_receptor_signaling_pathways"> NOD-like Receptor Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_oncostatin_m_signaling_pathways" action="/pathways/oncostatin-m-signaling-pathways" method="post"> <li class=""> <a href="/pathways/oncostatin-m-signaling-pathways" class="pathway_link" data-form="pathways_oncostatin_m_signaling_pathways"> Oncostatin M Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_pathogen_or_damage-activated_c-type_lectin_receptor_signaling_pathways" action="/pathways/pathogen-damage-activated-c-type-lectin-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/pathogen-damage-activated-c-type-lectin-receptor-signaling-pathways" class="pathway_link" data-form="pathways_pathogen_or_damage-activated_c-type_lectin_receptor_signaling_pathways"> Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_t_cell_co-signaling_pathway__ligand-receptor_interactions" action="/pathways/t-cell-co-signaling-pathway-lig-recept-interactions" method="post"> <li class=""> <a href="/pathways/t-cell-co-signaling-pathway-lig-recept-interactions" class="pathway_link" data-form="pathways_t_cell_co-signaling_pathway__ligand-receptor_interactions"> T Cell Co-Signaling Pathway: Ligand-Receptor Interactions </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_tgf-beta_signaling_pathways" action="/pathways/tgf-beta-signaling-pathways" method="post"> <li class=""> <a href="/pathways/tgf-beta-signaling-pathways" class="pathway_link" data-form="pathways_tgf-beta_signaling_pathways"> TGF-beta Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_th1_differentiation_pathway" action="/pathways/th1-differentiation-pathway" method="post"> <li class="active"> <a href="/pathways/th1-differentiation-pathway" class="pathway_link" data-form="pathways_th1_differentiation_pathway"> Th1 Differentiation Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_th17_differentiation_pathway" action="/pathways/th17-differentiation-pathway" method="post"> <li class=""> <a href="/pathways/th17-differentiation-pathway" class="pathway_link" data-form="pathways_th17_differentiation_pathway"> Th17 Differentiation Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_th2_differentiation_pathway" action="/pathways/th2-differentiation-pathway" method="post"> <li class=""> <a href="/pathways/th2-differentiation-pathway" class="pathway_link" data-form="pathways_th2_differentiation_pathway"> Th2 Differentiation Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_tnf_superfamily_pathway__human_ligand-receptor_interactions__their_associated_functions" action="/pathways/tnf-superfamily-pathway-human-lig-recept-interactions-their-associated-functions" method="post"> <li class=""> <a href="/pathways/tnf-superfamily-pathway-human-lig-recept-interactions-their-associated-functions" class="pathway_link" data-form="pathways_tnf_superfamily_pathway__human_ligand-receptor_interactions__their_associated_functions"> TNF Superfamily Pathway: Human Ligand-Receptor Interactions & their Associated Functions </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_toll-like_receptor_signaling_pathways" action="/pathways/toll-like-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/toll-like-receptor-signaling-pathways" class="pathway_link" data-form="pathways_toll-like_receptor_signaling_pathways"> Toll-Like Receptor Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_type_i_interferon_signaling_pathways" action="/pathways/type-i-interferon-signaling-pathways" method="post"> <li class=""> <a href="/pathways/type-i-interferon-signaling-pathways" class="pathway_link" data-form="pathways_type_i_interferon_signaling_pathways"> Type I Interferon Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_type_ii_interferon_signaling_pathways" action="/pathways/type-ii-interferon-signaling-pathways" method="post"> <li class=""> <a href="/pathways/type-ii-interferon-signaling-pathways" class="pathway_link" data-form="pathways_type_ii_interferon_signaling_pathways"> Type II Interferon Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_type_iii_interferon_signaling_pathways" action="/pathways/type-iii-interferon-signaling-pathways" method="post"> <li class=""> <a 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data-form="pathways_virus_detection_and_induction_of_antiviral_signaling_pathways_by_rig-i-like_receptors_rlr"> Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors RLR </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> </ul> </li> <li class="pathways-li "> <form id="pathways_neuroscience_pathways" action="/pathways/neuroscience" method="post"> <a href="/pathways/neuroscience" data-form="pathways_neuroscience_pathways" class="pathway_link"> <span class="icon-"> Neuroscience Pathways </span> </a> <input type="hidden" name="pw_parent" value="Neuroscience"> </form> </li> <li class="pathways-li "> <form id="pathways_proteases__other_enzymes_pathways" action="/pathways/proteases" method="post"> <a href="/pathways/proteases" data-form="pathways_proteases__other_enzymes_pathways" class="pathway_link"> <span class="icon-"> Proteases & Other Enzymes Pathways </span> </a> <input type="hidden" name="pw_parent" value="proteases"> </form> </li> <li class="pathways-li "> <form id="pathways_signal_transduction_pathways" action="/pathways/signal-transduction" method="post"> <a href="/pathways/signal-transduction" data-form="pathways_signal_transduction_pathways" class="pathway_link"> <span class="icon-"> Signal Transduction Pathways </span> </a> <input type="hidden" name="pw_parent" value="signal-transduction"> </form> </li> <li class="pathways-li "> <form id="pathways_stem_cell_pathways" action="/pathways/stem-cells" method="post"> <a href="/pathways/stem-cells" data-form="pathways_stem_cell_pathways" class="pathway_link"> <span class="icon-"> Stem Cell Pathways </span> </a> <input type="hidden" name="pw_parent" value="stem-cells"> </form> </li> <li class="pathways-li "> <form id="pathways_ubiquitin_related_modifiers__pathways" action="/pathways/ubiquitin-related-modifiers-and-pathways" method="post"> <a href="/pathways/ubiquitin-related-modifiers-and-pathways" data-form="pathways_ubiquitin_related_modifiers__pathways" class="pathway_link"> <span class="icon-"> Ubiquitin, Related Modifiers, & Pathways </span> </a> <input type="hidden" name="pw_parent" value="ubiquitin-related-modifiers-and-pathways"> </form> </li> </ul> </div> </div> </div> </div> </div> <div class="pw_right col-xs-12 col-sm-8 col-md-9"> <div class="search_mobile_buttons"> <div class="pw_menu_toggle btn btn-tertiary">Show Categories</div> </div> <div class="pw_header"> <h1>Th1 Differentiation Pathway</h1> <p id="pw-intro-txt">Click on one of the links shown in the Explore Pathways box below to see the processes that promote Th1 differentiation and the transcription factors, secreted molecules, and some of the cell surface markers that distinguish a differentiated Th1 cell from the other T helper cell subtypes.<br></p> <div id="pw-con" data-mapname="Th1 Antigen Presentation & Co-Stimulation" data-primary_segment="th1_all"> <div id="pw-main-nav-wrapper"> <div class="row"> <div id="pw-button-nav-top" class="col-xs-12 col-sm-12"> <div class="row"> <div id="pw-button-nav"> <div class="dropdown col-xs-12 col-sm-6 col-md-4"> <button class="btn-pw" type="button" data-toggle="dropup">Explore Pathways<span class="caret"></span></button> <ul id="pathwaynav" class="dropdown-content"> <li data-segment="th1_antigen" data-background_image="Th1_Step1.png" data-pathway_segment="Pathway_Th1 Antigen Presentation &amp Co-Stimulation" class="pw_rdblue_sm pw_sm_btn"><span>Antigen Presentation & Co-stimulation</span></li> <li data-segment="th1_lineage" data-background_image="Th1_Step2.png" data-pathway_segment="Pathway_Th1 Lineage Commitment" class="pw_rdblue_sm pw_sm_btn"><span>Th1 Lineage Commitment</span></li> <li data-segment="th1_differentiated" data-background_image="Th1_Step3.png" data-pathway_segment="Pathway_Th1 Differentiated Th1 Cell" class="pw_rdblue_sm pw_sm_btn"><span>Differentiated Th1 Cell</span></li> <li data-segment="Th1_All" data-background_image="Th1_all.png" data-pathway_segment="Pathway_Th1_All" class="pw_sm_btn-active"><span>View Full Pathway</span></li> </ul> </div> </div> <div class="col-xs-12 col-sm-6 col-md-5" > <div id="pw-nav-subtitle"> Th1 Differentiation Pathway </div> </div> <div id="pw-print-button-col" class="col-xs-12 col-sm-6 col-md-3" > <a href="#print-copy-form" id="btn-get-print-copy" class="btn btn-primary"><img class="btn-icon" src="https://resources.rndsystems.com/images/Pathways/icons/icon-image.svg"/> Get Print Copy</a> </div> </div> </div> </div> </div> <div id="pw-map"> <div id="pw-maps"> <div id="el1_gry" class="th1_all th1_antigen pw-sprite el-gray1 pw-gray" style="top:28px;left:477px;"> </div> <div id="el1_off" data-id="1" data-set="TLR1" data-type="" class="th1_all th1_antigen pw-sprite el-off1" style="top:28px;left:477px;"> </div> <div id="el1_ct" class="pw-tooltip" data-id="1"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/tlr1">TLR1</a><br> <a target="_blank" 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th1_antigen pw-label el-off37" style="top:167px;left:250px;"> STAT1 Dimer</div> <div id="el37_ct" class="pw-tooltip" data-id="37"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el38_gry" class="th1_all th1_antigen pw-sprite el-gray38 pw-gray" style="top:214px;left:254px;"> </div> <div id="el38_off" data-id="38" data-set="STAT1Dimer21" data-type="No Products Click" class="th1_all th1_antigen pw-sprite el-off38" style="top:214px;left:254px;"> </div> <div id="el38_ct" class="pw-tooltip" data-id="38"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el39_gry" class="th1_all th1_antigen pw-label el-gray39 pw-gray" style="top:222px;left:238px;"> STAT1 Dimer </div> <div id="el39_off" data-id="39" data-set="STAT1Dimer21" data-type="No Products Click" class="th1_all th1_antigen pw-label el-off39" style="top:222px;left:238px;"> STAT1 Dimer</div> <div id="el39_ct" class="pw-tooltip" data-id="39"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el40_gry" class="th1_all th1_antigen pw-label el-gray40 pw-gray" style="top:161px;left:355px;"> T-bet </div> <div id="el40_off" data-id="40" data-set="T-bet" data-type="No Products Click" class="th1_all th1_antigen pw-label el-off40" style="top:161px;left:355px;"> T-bet</div> <div id="el40_ct" class="pw-tooltip" data-id="40"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/t-bet-tbx21">T-bet/TBX21</a><br> </div> </div> <div id="el41_gry" class="th1_all th1_antigen pw-label el-gray41 pw-gray" style="top:224px;left:338px;"> GATA-3 </div> <div id="el41_off" data-id="41" data-set="GATA-3" data-type="No Products Click" class="th1_all th1_antigen pw-label el-off41" style="top:224px;left:338px;"> GATA-3</div> <div id="el41_ct" class="pw-tooltip" data-id="41"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/gata-3">GATA-3</a><br> </div> </div> <div id="el42_gry" class="th1_all th1_antigen pw-sprite el-gray42 pw-gray" style="top:13px;left:464px;"> </div> <div id="el42_off" data-id="42" data-set="Pathogen130" data-type="No Products Click" class="th1_all th1_antigen pw-sprite el-off42" style="top:13px;left:464px;"> </div> <div id="el42_ct" class="pw-tooltip" data-id="42"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el43_gry" class="th1_all th1_antigen pw-label el-gray43 pw-gray" style="top:21px;left:418px;"> Pathogen </div> <div id="el43_off" data-id="43" data-set="Pathogen130" data-type="No Products Click" class="th1_all th1_antigen pw-label el-off43" style="top:21px;left:418px;"> Pathogen</div> <div id="el43_ct" class="pw-tooltip" data-id="43"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el44_gry" class="th1_all th1_antigen pw-label2 el-gray44 pw-gray" style="top:143px;left:531px;"> Dendritic Cell </div> <div id="el44_off" data-id="44" data-set="DendriticCell" data-type="" class="th1_all th1_antigen pw-label2 el-off44" style="top:143px;left:531px;"> Dendritic Cell</div> <div id="el44_ct" class="pw-tooltip" data-id="44"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el45_gry" class="th1_all th1_antigen pw-label2 el-gray45 pw-gray" style="top:291px;left:34px;"> Naive CD4<sup>+</sup> T Cell </div> <div id="el45_off" data-id="45" data-set="NaiveCD4TCell" data-type="" class="th1_all th1_antigen pw-label2 el-off45" style="top:291px;left:34px;"> Naive CD4<sup>+</sup> T Cell</div> <div id="el45_ct" class="pw-tooltip" data-id="45"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el46_gry" class="th1_all th1_differentiated pw-label el-gray46 pw-gray" style="top:372px;left:205px;"> IL-18 </div> <div id="el46_off" data-id="46" data-set="IL-18" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off46" style="top:372px;left:205px;"> IL-18</div> <div id="el46_ct" class="pw-tooltip" data-id="46"> <div 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style="top:429px;left:153px;"> IL-18 R alpha</div> <div id="el48_ct" class="pw-tooltip" data-id="48"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-18-r-alpha-il-1-r5">IL-18 R alpha/IL-1 R5</a><br> </div> </div> <div id="el49_gry" class="th1_all th1_differentiated pw-sprite el-gray49 pw-gray" style="top:399px;left:225px;"> </div> <div id="el49_off" data-id="49" data-set="IL-18Rbeta48" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off49" style="top:399px;left:225px;"> </div> <div id="el49_ct" class="pw-tooltip" data-id="49"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-18-r-beta-il-1-r7">IL-18 R beta/IL-1 R7</a><br> </div> </div> <div id="el50_gry" class="th1_all th1_differentiated pw-label el-gray50 pw-gray" style="top:388px;left:119px;"> IL-18 R beta </div> <div id="el50_off" data-id="50" data-set="IL-18Rbeta48" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off50" style="top:388px;left:119px;"> IL-18 R beta</div> <div id="el50_ct" class="pw-tooltip" data-id="50"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-18-r-beta-il-1-r7">IL-18 R beta/IL-1 R7</a><br> </div> </div> <div id="el51_gry" class="th1_all th1_differentiated pw-sprite el-gray51 pw-gray" style="top:435px;left:114px;"> </div> <div id="el51_off" data-id="51" data-set="IL-27RalphaWSX-149" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off51" style="top:435px;left:114px;"> </div> <div id="el51_ct" class="pw-tooltip" data-id="51"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-27-r-alpha-wsx-1-tccr">IL-27 R alpha/WSX-1/TCCR</a><br> </div> </div> <div id="el52_gry" class="th1_all th1_differentiated pw-label pw-center el-gray52 pw-gray" style="top:411px;left:27px;"> IL-27 R alpha/<br>WSX-1 </div> <div id="el52_off" data-id="52" data-set="IL-27RalphaWSX-149" data-type="No Products Click" class="th1_all th1_differentiated pw-label pw-center el-off52" style="top:411px;left:27px;"> IL-27 R alpha/<br>WSX-1</div> <div id="el52_ct" class="pw-tooltip" data-id="52"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-27-r-alpha-wsx-1-tccr">IL-27 R alpha/WSX-1/TCCR</a><br> </div> </div> <div id="el53_gry" class="th1_all th1_differentiated pw-sprite el-gray53 pw-gray" style="top:434px;left:95px;"> </div> <div id="el53_off" data-id="53" data-set="gp13050" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off53" style="top:434px;left:95px;"> </div> <div id="el53_ct" class="pw-tooltip" data-id="53"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/gp130">gp130</a><br> </div> </div> <div id="el54_gry" class="th1_all th1_differentiated pw-label el-gray54 pw-gray" style="top:460px;left:81px;"> gp130 </div> <div id="el54_off" data-id="54" data-set="gp13050" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off54" style="top:460px;left:81px;"> gp130</div> <div id="el54_ct" class="pw-tooltip" data-id="54"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/gp130">gp130</a><br> </div> </div> <div id="el55_gry" class="th1_all th1_differentiated pw-label el-gray55 pw-gray" style="top:487px;left:17px;"> IL-12 </div> <div id="el55_off" data-id="55" data-set="IL-12" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off55" style="top:487px;left:17px;"> IL-12</div> <div id="el55_ct" class="pw-tooltip" data-id="55"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-12">IL-12</a><br> <a target="_blank" href="/target/il-12 p70">IL-12 p70</a><br> <a target="_blank" href="/target/il-12/IL-35 p35">IL-12/IL-35 p35</a><br> <a target="_blank" href="/target/il-12/IL-23 p40">IL-12/IL-23 p40</a><br> </div> </div> <div id="el56_gry" class="th1_all th1_differentiated pw-sprite el-gray56 pw-gray" style="top:502px;left:54px;"> </div> <div id="el56_off" data-id="56" data-set="IL-12Rbeta152" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off56" style="top:502px;left:54px;"> </div> <div id="el56_ct" class="pw-tooltip" data-id="56"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-12-r-beta-1">IL-12 R beta 1</a><br> </div> </div> <div id="el57_gry" class="th1_all th1_differentiated pw-label el-gray57 pw-gray" style="top:494px;left:73px;"> IL-12 R beta 1 </div> <div id="el57_off" data-id="57" data-set="IL-12Rbeta152" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off57" style="top:494px;left:73px;"> IL-12 R beta 1</div> <div id="el57_ct" class="pw-tooltip" data-id="57"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-12-r-beta-1">IL-12 R beta 1</a><br> </div> </div> <div id="el58_gry" class="th1_all th1_differentiated pw-sprite el-gray58 pw-gray" style="top:504px;left:41px;"> </div> <div id="el58_off" data-id="58" data-set="IL-12Rbeta253" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off58" style="top:504px;left:41px;"> </div> <div id="el58_ct" class="pw-tooltip" data-id="58"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-12-r-beta-2">IL-12 R beta 2</a><br> </div> </div> <div id="el59_gry" class="th1_all th1_differentiated pw-label el-gray59 pw-gray" style="top:548px;left:32px;"> IL-12 R beta 2 </div> <div id="el59_off" data-id="59" data-set="IL-12Rbeta253" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off59" style="top:548px;left:32px;"> IL-12 R beta 2</div> <div id="el59_ct" class="pw-tooltip" data-id="59"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-12-r-beta-2">IL-12 R beta 2</a><br> </div> </div> <div id="el60_gry" class="th1_all th1_differentiated pw-sprite el-gray60 pw-gray" style="top:527px;left:135px;"> </div> <div id="el60_off" data-id="60" data-set="Tyk254" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off60" style="top:527px;left:135px;"> </div> <div id="el60_ct" class="pw-tooltip" data-id="60"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/tyk2">Tyk2</a><br> </div> </div> <div id="el61_gry" class="th1_all th1_differentiated pw-label el-gray61 pw-gray" style="top:534px;left:158px;"> Tyk2 </div> <div id="el61_off" data-id="61" data-set="Tyk254" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off61" style="top:534px;left:158px;"> Tyk2</div> <div id="el61_ct" class="pw-tooltip" data-id="61"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/tyk2">Tyk2</a><br> </div> </div> <div id="el62_gry" class="th1_all th1_differentiated pw-sprite el-gray62 pw-gray" style="top:554px;left:122px;"> </div> <div id="el62_off" data-id="62" data-set="Jak255" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off62" style="top:554px;left:122px;"> </div> <div id="el62_ct" class="pw-tooltip" data-id="62"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak2">Jak2</a><br> </div> </div> <div id="el63_gry" class="th1_all th1_differentiated pw-label el-gray63 pw-gray" style="top:576px;left:120px;"> Jak2 </div> <div id="el63_off" data-id="63" data-set="Jak255" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off63" style="top:576px;left:120px;"> Jak2</div> <div id="el63_ct" class="pw-tooltip" data-id="63"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak2">Jak2</a><br> </div> </div> <div id="el64_gry" class="th1_all th1_differentiated pw-sprite el-gray64 pw-gray" style="top:622px;left:102px;"> </div> <div id="el64_off" data-id="64" data-set="Jak256" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off64" style="top:622px;left:102px;"> </div> <div id="el64_ct" class="pw-tooltip" data-id="64"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak2">Jak2</a><br> </div> </div> <div id="el65_gry" class="th1_all th1_differentiated pw-label el-gray65 pw-gray" style="top:617px;left:106px;"> Jak2 </div> <div id="el65_off" data-id="65" data-set="Jak256" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off65" style="top:617px;left:106px;"> Jak2</div> <div id="el65_ct" class="pw-tooltip" data-id="65"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak2">Jak2</a><br> </div> </div> <div id="el66_gry" class="th1_all th1_differentiated pw-label el-gray66 pw-gray" style="top:615px;left:0px;"> IFN-gamma </div> <div id="el66_off" data-id="66" data-set="IFN-gamma" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off66" style="top:615px;left:0px;"> IFN-gamma</div> <div id="el66_ct" class="pw-tooltip" data-id="66"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-gamma">IFN-gamma</a><br> </div> </div> <div id="el67_gry" class="th1_all th1_differentiated pw-sprite el-gray67 pw-gray" style="top:633px;left:66px;"> </div> <div id="el67_off" data-id="67" data-set="IFN-gammaR158" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off67" style="top:633px;left:66px;"> </div> <div id="el67_ct" class="pw-tooltip" data-id="67"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-gamma-r1-cd119">IFN-gamma R1/CD119</a><br> </div> </div> <div id="el68_gry" class="th1_all th1_differentiated pw-label el-gray68 pw-gray" style="top:664px;left:5px;"> IFN-gamma R1 </div> <div id="el68_off" data-id="68" data-set="IFN-gammaR158" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off68" style="top:664px;left:5px;"> IFN-gamma R1</div> <div id="el68_ct" class="pw-tooltip" data-id="68"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-gamma-r1-cd119">IFN-gamma R1/CD119</a><br> </div> </div> <div id="el69_gry" class="th1_all th1_differentiated pw-sprite el-gray69 pw-gray" style="top:631px;left:63px;"> </div> <div id="el69_off" data-id="69" data-set="IFN-gammaR259" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off69" style="top:631px;left:63px;"> </div> <div id="el69_ct" class="pw-tooltip" data-id="69"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-gamma-r2">IFN-gamma R2</a><br> </div> </div> <div id="el70_gry" class="th1_all th1_differentiated pw-label el-gray70 pw-gray" style="top:588px;left:11px;"> IFN-gamma R2 </div> <div id="el70_off" data-id="70" data-set="IFN-gammaR259" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off70" style="top:588px;left:11px;"> IFN-gamma R2</div> <div id="el70_ct" class="pw-tooltip" data-id="70"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-gamma-r2">IFN-gamma R2</a><br> </div> </div> <div id="el71_gry" class="th1_all th1_differentiated pw-sprite el-gray71 pw-gray" style="top:626px;left:115px;"> </div> <div id="el71_off" data-id="71" data-set="Jak160" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off71" style="top:626px;left:115px;"> </div> <div id="el71_ct" class="pw-tooltip" data-id="71"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak1">Jak1</a><br> </div> </div> <div id="el72_gry" class="th1_all th1_differentiated pw-label el-gray72 pw-gray" style="top:631px;left:139px;"> Jak1 </div> <div id="el72_off" data-id="72" data-set="Jak160" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off72" style="top:631px;left:139px;"> Jak1</div> <div id="el72_ct" class="pw-tooltip" data-id="72"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak1">Jak1</a><br> </div> </div> <div id="el73_gry" class="th1_all th1_differentiated pw-sprite el-gray73 pw-gray" style="top:639px;left:115px;"> </div> <div id="el73_off" data-id="73" data-set="Jak161" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off73" style="top:639px;left:115px;"> </div> <div id="el73_ct" class="pw-tooltip" data-id="73"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak1">Jak1</a><br> </div> </div> <div id="el74_gry" class="th1_all th1_differentiated pw-label el-gray74 pw-gray" style="top:654px;left:138px;"> Jak1 </div> <div id="el74_off" data-id="74" data-set="Jak161" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off74" style="top:654px;left:138px;"> Jak1</div> <div id="el74_ct" class="pw-tooltip" data-id="74"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak1">Jak1</a><br> </div> </div> <div id="el75_gry" class="th1_all th1_differentiated pw-sprite el-gray75 pw-gray" style="top:642px;left:102px;"> </div> <div id="el75_off" data-id="75" data-set="Jak262" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off75" style="top:642px;left:102px;"> </div> <div id="el75_ct" class="pw-tooltip" data-id="75"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak2">Jak2</a><br> </div> </div> <div id="el76_gry" class="th1_all th1_differentiated pw-label el-gray76 pw-gray" style="top:664px;left:105px;"> Jak2 </div> <div id="el76_off" data-id="76" data-set="Jak262" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off76" style="top:664px;left:105px;"> Jak2</div> <div id="el76_ct" class="pw-tooltip" data-id="76"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak2">Jak2</a><br> </div> </div> <div id="el77_gry" class="th1_all th1_differentiated pw-sprite el-gray77 pw-gray" style="top:517px;left:223px;"> </div> <div id="el77_off" data-id="77" data-set="STAT463" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off77" style="top:517px;left:223px;"> </div> <div id="el77_ct" class="pw-tooltip" data-id="77"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat4">STAT4</a><br> </div> </div> <div id="el78_gry" class="th1_all th1_differentiated pw-label el-gray78 pw-gray" style="top:527px;left:222px;"> STAT4 </div> <div id="el78_off" data-id="78" data-set="STAT463" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off78" style="top:527px;left:222px;"> STAT4</div> <div id="el78_ct" class="pw-tooltip" data-id="78"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat4">STAT4</a><br> </div> </div> <div id="el79_gry" class="th1_all th1_differentiated pw-sprite el-gray79 pw-gray" style="top:559px;left:208px;"> </div> <div id="el79_off" data-id="79" data-set="STAT364" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off79" style="top:559px;left:208px;"> </div> <div id="el79_ct" class="pw-tooltip" data-id="79"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat3">STAT3</a><br> </div> </div> <div id="el80_gry" class="th1_all th1_differentiated pw-label el-gray80 pw-gray" style="top:568px;left:207px;"> STAT3 </div> <div id="el80_off" data-id="80" data-set="STAT364" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off80" style="top:568px;left:207px;"> STAT3</div> <div id="el80_ct" class="pw-tooltip" data-id="80"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat3">STAT3</a><br> </div> </div> <div id="el81_gry" class="th1_all th1_differentiated pw-sprite el-gray81 pw-gray" style="top:599px;left:179px;"> </div> <div id="el81_off" data-id="81" data-set="STAT565" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off81" style="top:599px;left:179px;"> </div> <div id="el81_ct" class="pw-tooltip" data-id="81"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat5a">STAT5a</a><br> <a target="_blank" href="/target/stat5a/b">STAT5a/b</a><br> <a target="_blank" href="/target/stat5b">STAT5b</a><br> </div> </div> <div id="el82_gry" class="th1_all th1_differentiated pw-label el-gray82 pw-gray" style="top:609px;left:178px;"> STAT5 </div> <div id="el82_off" data-id="82" data-set="STAT565" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off82" style="top:609px;left:178px;"> STAT5</div> <div id="el82_ct" class="pw-tooltip" data-id="82"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat5a">STAT5a</a><br> <a target="_blank" href="/target/stat5a/b">STAT5a/b</a><br> <a target="_blank" href="/target/stat5b">STAT5b</a><br> </div> </div> <div id="el83_gry" class="th1_all th1_differentiated pw-sprite el-gray83 pw-gray" style="top:638px;left:179px;"> </div> <div id="el83_off" data-id="83" data-set="STAT166" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off83" style="top:638px;left:179px;"> </div> <div id="el83_ct" class="pw-tooltip" data-id="83"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el84_gry" class="th1_all th1_differentiated pw-label el-gray84 pw-gray" style="top:648px;left:175px;"> STAT1 </div> <div id="el84_off" data-id="84" data-set="STAT166" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off84" style="top:648px;left:175px;"> STAT1</div> <div id="el84_ct" class="pw-tooltip" data-id="84"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el85_gry" class="th1_all th1_differentiated pw-sprite el-gray85 pw-gray" style="top:544px;left:260px;"> </div> <div id="el85_off" data-id="85" data-set="STAT4Dimer67" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off85" style="top:544px;left:260px;"> </div> <div id="el85_ct" class="pw-tooltip" data-id="85"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat4">STAT4</a><br> </div> </div> <div id="el86_gry" class="th1_all th1_differentiated pw-label el-gray86 pw-gray" style="top:552px;left:243px;"> STAT4 Dimer </div> <div id="el86_off" data-id="86" data-set="STAT4Dimer67" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off86" style="top:552px;left:243px;"> STAT4 Dimer</div> <div id="el86_ct" class="pw-tooltip" data-id="86"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat4">STAT4</a><br> </div> </div> <div id="el87_gry" class="th1_all th1_differentiated pw-sprite el-gray87 pw-gray" style="top:590px;left:238px;"> </div> <div id="el87_off" data-id="87" data-set="STAT1Dimer68" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off87" style="top:590px;left:238px;"> </div> <div id="el87_ct" class="pw-tooltip" data-id="87"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el88_gry" class="th1_all th1_differentiated pw-label el-gray88 pw-gray" style="top:598px;left:220px;"> STAT1 Dimer </div> <div id="el88_off" data-id="88" data-set="STAT1Dimer68" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off88" style="top:598px;left:220px;"> STAT1 Dimer</div> <div id="el88_ct" class="pw-tooltip" data-id="88"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el89_gry" class="th1_all th1_differentiated pw-sprite el-gray89 pw-gray" style="top:566px;left:396px;"> </div> <div id="el89_off" data-id="89" data-set="AP-169" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off89" style="top:566px;left:396px;"> </div> <div id="el89_ct" class="pw-tooltip" data-id="89"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/c-jun">c-Jun</a><br> <a target="_blank" href="/target/c-fos">c-Fos</a><br> <a target="_blank" href="/target/junb">JunB</a><br> <a target="_blank" href="/target/jund">JunD</a><br> <a target="_blank" href="/target/fosb-g0s3">FosB/G0S3</a><br> <a target="_blank" href="/target/fra-1">FRA-1</a><br> </div> </div> <div id="el90_gry" class="th1_all th1_differentiated pw-label el-gray90 pw-gray" style="top:573px;left:406px;"> AP-1 </div> <div id="el90_off" data-id="90" data-set="AP-169" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off90" style="top:573px;left:406px;"> AP-1</div> <div id="el90_ct" class="pw-tooltip" data-id="90"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/c-jun">c-Jun</a><br> <a target="_blank" href="/target/c-fos">c-Fos</a><br> <a target="_blank" href="/target/junb">JunB</a><br> <a target="_blank" href="/target/jund">JunD</a><br> <a target="_blank" href="/target/fosb-g0s3">FosB/G0S3</a><br> <a target="_blank" href="/target/fra-1">FRA-1</a><br> </div> </div> <div id="el91_gry" class="th1_all th1_differentiated pw-label el-gray91 pw-gray" style="top:563px;left:454px;"> IFN-gamma </div> <div id="el91_off" data-id="91" data-set="IFN-gamma" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off91" style="top:563px;left:454px;"> IFN-gamma</div> <div id="el91_ct" class="pw-tooltip" data-id="91"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-gamma">IFN-gamma</a><br> </div> </div> <div id="el92_gry" class="th1_all th1_differentiated pw-sprite el-gray92 pw-gray" style="top:620px;left:346px;"> </div> <div id="el92_off" data-id="92" data-set="STAT4Dimer71" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off92" style="top:620px;left:346px;"> </div> <div id="el92_ct" class="pw-tooltip" data-id="92"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat4">STAT4</a><br> </div> </div> <div id="el93_gry" class="th1_all th1_differentiated pw-label el-gray93 pw-gray" style="top:625px;left:308px;"> STAT4 Dimer </div> <div id="el93_off" data-id="93" data-set="STAT4Dimer71" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off93" style="top:625px;left:308px;"> STAT4 Dimer</div> <div id="el93_ct" class="pw-tooltip" data-id="93"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat4">STAT4</a><br> </div> </div> <div id="el94_gry" class="th1_all th1_differentiated pw-label el-gray94 pw-gray" style="top:618px;left:406px;"> IFN-gamma </div> <div id="el94_off" data-id="94" data-set="IFN-gamma" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off94" style="top:618px;left:406px;"> IFN-gamma</div> <div id="el94_ct" class="pw-tooltip" data-id="94"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-gamma">IFN-gamma</a><br> </div> </div> <div id="el95_gry" class="th1_all th1_differentiated pw-label el-gray95 pw-gray" style="top:633px;left:406px;"> IL-18 R beta </div> <div id="el95_off" data-id="95" data-set="IL-18Rbeta" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off95" style="top:633px;left:406px;"> IL-18 R beta</div> <div id="el95_ct" class="pw-tooltip" data-id="95"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-18-r-beta-il-1-r7">IL-18 R beta/IL-1 R7</a><br> </div> </div> <div id="el96_gry" class="th1_all th1_differentiated pw-sprite el-gray96 pw-gray" style="top:670px;left:310px;"> </div> <div id="el96_off" data-id="96" data-set="STAT1Dimer74" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off96" style="top:670px;left:310px;"> </div> <div id="el96_ct" class="pw-tooltip" data-id="96"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el97_gry" class="th1_all th1_differentiated pw-label el-gray97 pw-gray" style="top:676px;left:280px;"> STAT1 Dimer </div> <div id="el97_off" data-id="97" data-set="STAT1Dimer74" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off97" style="top:676px;left:280px;"> STAT1 Dimer</div> <div id="el97_ct" class="pw-tooltip" data-id="97"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el98_gry" class="th1_all th1_differentiated pw-label el-gray98 pw-gray" style="top:674px;left:375px;"> T-bet </div> <div id="el98_off" data-id="98" data-set="T-bet" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off98" style="top:674px;left:375px;"> T-bet</div> <div id="el98_ct" class="pw-tooltip" data-id="98"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/t-bet-tbx21">T-bet/TBX21</a><br> </div> </div> <div id="el99_gry" class="th1_all th1_differentiated pw-sprite el-gray99 pw-gray" style="top:700px;left:377px;"> </div> <div id="el99_off" data-id="99" data-set="T-bet76" data-type="No Products Click" class="th1_all th1_differentiated pw-sprite el-off99" style="top:700px;left:377px;"> </div> <div id="el99_ct" class="pw-tooltip" data-id="99"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/t-bet-tbx21">T-bet/TBX21</a><br> </div> </div> <div id="el100_gry" class="th1_all th1_differentiated pw-label el-gray100 pw-gray" style="top:707px;left:379px;"> T-bet </div> <div id="el100_off" data-id="100" data-set="T-bet76" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off100" style="top:707px;left:379px;"> T-bet</div> <div id="el100_ct" class="pw-tooltip" data-id="100"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/t-bet-tbx21">T-bet/TBX21</a><br> </div> </div> <div id="el101_gry" class="th1_all th1_differentiated pw-label el-gray101 pw-gray" style="top:704px;left:425px;"> IFN-gamma </div> <div id="el101_off" data-id="101" data-set="IFN-gamma" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off101" style="top:704px;left:425px;"> IFN-gamma</div> <div id="el101_ct" class="pw-tooltip" data-id="101"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-gamma">IFN-gamma</a><br> </div> </div> <div id="el102_gry" class="th1_all th1_differentiated pw-label el-gray102 pw-gray" style="top:713px;left:48px;"> IL-10 </div> <div id="el102_off" data-id="102" data-set="IL-10" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off102" style="top:713px;left:48px;"> IL-10</div> <div id="el102_ct" class="pw-tooltip" data-id="102"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-10">IL-10</a><br> </div> </div> <div id="el103_gry" class="th1_all th1_differentiated pw-label el-gray103 pw-gray" style="top:799px;left:106px;"> TNF-alpha </div> <div id="el103_off" data-id="103" data-set="TNF-alpha" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off103" style="top:799px;left:106px;"> TNF-alpha</div> <div id="el103_ct" class="pw-tooltip" data-id="103"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/tnf-alpha">TNF-alpha</a><br> </div> </div> <div id="el104_gry" class="th1_all th1_differentiated pw-label el-gray104 pw-gray" style="top:814px;left:106px;"> TNF-beta </div> <div id="el104_off" data-id="104" data-set="TNF-beta" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off104" style="top:814px;left:106px;"> TNF-beta</div> <div id="el104_ct" class="pw-tooltip" data-id="104"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/lymphotoxin-alpha-tnf-beta">Lymphotoxin-alpha/TNF-beta</a><br> </div> </div> <div id="el105_gry" class="th1_all th1_differentiated pw-label el-gray105 pw-gray" style="top:843px;left:217px;"> IFN-gamma </div> <div id="el105_off" data-id="105" data-set="IFN-gamma" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off105" style="top:843px;left:217px;"> IFN-gamma</div> <div id="el105_ct" class="pw-tooltip" data-id="105"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-gamma">IFN-gamma</a><br> </div> </div> <div id="el106_gry" class="th1_all th1_differentiated pw-label el-gray106 pw-gray" style="top:838px;left:353px;"> IL-2 </div> <div id="el106_off" data-id="106" data-set="IL-2" data-type="No Products Click" class="th1_all th1_differentiated pw-label el-off106" style="top:838px;left:353px;"> IL-2</div> <div id="el106_ct" class="pw-tooltip" data-id="106"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-2">IL-2</a><br> </div> </div> <div id="el107_gry" class="th1_all th1_differentiated pw-label2 el-gray107 pw-gray" style="top:662px;left:507px;"> Th1 Cell </div> <div id="el107_off" data-id="107" data-set="Th1Cell" data-type="" class="th1_all th1_differentiated pw-label2 el-off107" style="top:662px;left:507px;"> Th1 Cell</div> <div id="el107_ct" class="pw-tooltip" data-id="107"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el108_gry" class="th1_all th1_lineage pw-label el-gray108 pw-gray" style="top:190px;left:629px;"> IL-27 </div> <div id="el108_off" data-id="108" data-set="IL-27" data-type="No Products Click" class="th1_all th1_lineage pw-label el-off108" style="top:190px;left:629px;"> IL-27</div> <div id="el108_ct" class="pw-tooltip" data-id="108"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-27">IL-27</a><br> <a target="_blank" href="/target/il-27 p28/IL-30">IL-27 p28/IL-30</a><br> <a target="_blank" href="/target/il-27/IL-35 EBI3 Subunit">IL-27/IL-35 EBI3 Subunit</a><br> </div> </div> <div id="el109_gry" class="th1_all th1_lineage pw-label el-gray109 pw-gray" style="top:264px;left:706px;"> IL-12 </div> <div id="el109_off" data-id="109" data-set="IL-12" data-type="No Products Click" class="th1_all th1_lineage pw-label el-off109" style="top:264px;left:706px;"> IL-12</div> <div id="el109_ct" class="pw-tooltip" data-id="109"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-12">IL-12</a><br> <a target="_blank" href="/target/il-12 p70">IL-12 p70</a><br> <a target="_blank" href="/target/il-12/IL-35 p35">IL-12/IL-35 p35</a><br> <a target="_blank" href="/target/il-12/IL-23 p40">IL-12/IL-23 p40</a><br> </div> </div> <div id="el110_gry" class="th1_all th1_lineage pw-sprite el-gray110 pw-gray" style="top:203px;left:527px;"> </div> <div id="el110_off" data-id="110" data-set="IL-27Ralpha-WSX-1126" data-type="No Products Click" class="th1_all th1_lineage pw-sprite el-off110" style="top:203px;left:527px;"> </div> <div id="el110_ct" class="pw-tooltip" data-id="110"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-27-r-alpha-wsx-1-tccr">IL-27 R alpha/WSX-1/TCCR</a><br> </div> </div> <div id="el111_gry" class="th1_all th1_lineage pw-label pw-center el-gray111 pw-gray" style="top:202px;left:513px;"> IL-27 R alpha/<br>WSX-1 </div> <div id="el111_off" data-id="111" data-set="IL-27Ralpha-WSX-1126" data-type="No Products Click" class="th1_all th1_lineage pw-label pw-center el-off111" style="top:202px;left:513px;"> IL-27 R alpha/<br>WSX-1</div> <div id="el111_ct" class="pw-tooltip" data-id="111"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-27-r-alpha-wsx-1-tccr">IL-27 R alpha/WSX-1/TCCR</a><br> </div> </div> <div id="el112_gry" class="th1_all th1_lineage pw-sprite el-gray112 pw-gray" style="top:201px;left:538px;"> </div> <div id="el112_off" data-id="112" data-set="gp130127" data-type="No Products Click" class="th1_all th1_lineage pw-sprite el-off112" style="top:201px;left:538px;"> </div> <div id="el112_ct" class="pw-tooltip" data-id="112"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/gp130">gp130</a><br> </div> </div> <div id="el113_gry" class="th1_all th1_lineage pw-label el-gray113 pw-gray" style="top:224px;left:605px;"> gp130 </div> <div id="el113_off" data-id="113" data-set="gp130127" data-type="No Products Click" class="th1_all th1_lineage pw-label el-off113" style="top:224px;left:605px;"> gp130</div> <div id="el113_ct" class="pw-tooltip" data-id="113"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/gp130">gp130</a><br> </div> </div> <div id="el114_gry" class="th1_all th1_lineage pw-sprite el-gray114 pw-gray" style="top:273px;left:576px;"> </div> <div id="el114_off" data-id="114" data-set="IL-12Rbeta1128" data-type="No Products Click" class="th1_all th1_lineage pw-sprite el-off114" style="top:273px;left:576px;"> </div> <div id="el114_ct" class="pw-tooltip" data-id="114"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-12-r-beta-1">IL-12 R beta 1</a><br> </div> </div> <div id="el115_gry" class="th1_all th1_lineage pw-label el-gray115 pw-gray" style="top:239px;left:660px;"> IL-12 R beta 1 </div> <div id="el115_off" data-id="115" data-set="IL-12Rbeta1128" data-type="No Products Click" class="th1_all th1_lineage pw-label el-off115" style="top:239px;left:660px;"> IL-12 R beta 1</div> <div id="el115_ct" class="pw-tooltip" data-id="115"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-12-r-beta-1">IL-12 R beta 1</a><br> </div> </div> <div id="el116_gry" class="th1_all th1_lineage pw-sprite el-gray116 pw-gray" style="top:271px;left:584px;"> </div> <div id="el116_off" data-id="116" data-set="IL-12Rbeta2129" data-type="No Products Click" class="th1_all th1_lineage pw-sprite el-off116" style="top:271px;left:584px;"> </div> <div id="el116_ct" class="pw-tooltip" data-id="116"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-12-r-beta-2">IL-12 R beta 2</a><br> </div> </div> <div id="el117_gry" class="th1_all th1_lineage pw-label el-gray117 pw-gray" style="top:299px;left:661px;"> IL-12 R beta 2 </div> <div id="el117_off" data-id="117" data-set="IL-12Rbeta2129" data-type="No Products Click" class="th1_all th1_lineage pw-label el-off117" style="top:299px;left:661px;"> IL-12 R beta 2</div> <div id="el117_ct" class="pw-tooltip" data-id="117"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/il-12-r-beta-2">IL-12 R beta 2</a><br> </div> </div> <div id="el118_gry" class="th1_all th1_lineage pw-sprite el-gray118 pw-gray" style="top:261px;left:517px;"> </div> <div id="el118_off" data-id="118" data-set="Jak1130" data-type="No Products Click" class="th1_all th1_lineage pw-sprite el-off118" style="top:261px;left:517px;"> </div> <div id="el118_ct" class="pw-tooltip" data-id="118"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak1">Jak1</a><br> </div> </div> <div id="el119_gry" class="th1_all th1_lineage pw-label el-gray119 pw-gray" style="top:266px;left:503px;"> Jak1 </div> <div id="el119_off" data-id="119" data-set="Jak1130" data-type="No Products Click" class="th1_all th1_lineage pw-label el-off119" style="top:266px;left:503px;"> Jak1</div> <div id="el119_ct" class="pw-tooltip" data-id="119"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak1">Jak1</a><br> </div> </div> <div id="el120_gry" class="th1_all th1_lineage pw-sprite el-gray120 pw-gray" style="top:276px;left:541px;"> </div> <div id="el120_off" data-id="120" data-set="Jak1131" data-type="No Products Click" class="th1_all th1_lineage pw-sprite el-off120" style="top:276px;left:541px;"> </div> <div id="el120_ct" class="pw-tooltip" data-id="120"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak1">Jak1</a><br> </div> </div> <div id="el121_gry" class="th1_all th1_lineage pw-label el-gray121 pw-gray" style="top:278px;left:571px;"> Jak1 </div> <div id="el121_off" data-id="121" data-set="Jak1131" data-type="No Products Click" class="th1_all th1_lineage pw-label el-off121" style="top:278px;left:571px;"> Jak1</div> <div id="el121_ct" class="pw-tooltip" data-id="121"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak1">Jak1</a><br> </div> </div> <div id="el122_gry" class="th1_all th1_lineage pw-sprite el-gray122 pw-gray" style="top:278px;left:536px;"> </div> <div id="el122_off" data-id="122" data-set="Jak2132" data-type="No Products Click" class="th1_all th1_lineage pw-sprite el-off122" style="top:278px;left:536px;"> </div> <div id="el122_ct" class="pw-tooltip" data-id="122"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak2">Jak2</a><br> </div> </div> <div id="el123_gry" class="th1_all th1_lineage pw-label el-gray123 pw-gray" style="top:296px;left:565px;"> Jak2 </div> <div id="el123_off" data-id="123" data-set="Jak2132" data-type="No Products Click" class="th1_all th1_lineage pw-label el-off123" style="top:296px;left:565px;"> Jak2</div> <div id="el123_ct" class="pw-tooltip" data-id="123"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak2">Jak2</a><br> </div> </div> <div id="el124_gry" class="th1_all th1_lineage pw-sprite el-gray124 pw-gray" style="top:277px;left:529px;"> </div> <div id="el124_off" data-id="124" data-set="Tyk2133" data-type="No Products Click" class="th1_all th1_lineage pw-sprite el-off124" style="top:277px;left:529px;"> </div> <div id="el124_ct" class="pw-tooltip" data-id="124"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/tyk2">Tyk2</a><br> </div> </div> <div id="el125_gry" class="th1_all th1_lineage pw-label el-gray125 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src="https://resources.rndsystems.com/images/Pathways/pathway-images/th1_all.png" alt="Th1 Differentiation Pathway" style="height:892px"> </div> </div> <div id="pathway-description"><p><div class="row"> <div class="col-md-4 col-xs-12"> <div class="featured-box"> <h2>Featured Literature</h2> <img src="//resources.rndsystems.com/images/site/pathway-resource-t-cell-poster-tn.jpg" alt="CD4+ T Cell Subset Characterization Brochure" width="100%"> <h3>T Cell Subsets Poster</h3> <a href="/resources/posters/t-cell-subsets" class="btn btn-senary" target="_blank">View Poster</a> </div> </div> <div class="col-md-4 col-xs-12"> <div class="featured-box"> <h2>Featured Products</h2> <img src="//resources.rndsystems.com/images/site/pathway-resource-t-cell-subset-tn.jpg" alt="CD4+ T Cell Subset Characterization Brochure" width="100%"> <h3>CD4<sup>+</sup> T Cell Subset Characterization Brochure</h3> <a href="/resources/literature/methods-isolation-differentiation-and-characterization-cd4-t-cell-subsets" class="btn btn-senary" target="_blank">View Brochure</a> </div> </div> <div style="clear:both"> </div> </div> <h2>Overview of Th1 Differentiation</h2> <style type="text/css"> .container_16 {padding:0px !important;} .main.grid_16, .grid_16.base_rnd_css {width:1170px !important;} #pw-nav-con { width: 750px; height: inherit !important; background: none; } #pw-nav-con H2 { margin: 7px 0 5px 16px; padding: 5px 0; font-size: 19px; font-weight: inherit; width: 730px; border: none; } #pw-nav-con ul { margin: 0; padding: 0; height: 40px; } .pw-blu-btn { width: inherit; float: left; margin-left: 15px;} #pw-nav-con .pw-blu-btn a { background: #005F9E; border-top: 1px solid #005f9f;} #pw-nav-con .pw-blu-btn-active { border-top: none;} #pw-nav-con .pw-drk-blu-btn, #pw-nav-con li a /*request print button*/ { display: initial; padding: 5px 10px; font-weight: bold; background: #ffffff; border: 1px solid #005f9f; color: #090909; border-radius: 4px;} #pw-nav-con .pw-blu-btn-active { margin-left: 15px; float: left;} .related-information { background: #efefef; border: 1px solid #cccccc; position: relative; top: -54px;} .featured-links { display: block; text-decoration: none;} </style> <p>CD4<sup>+</sup> T cells play a central role in the adaptive immune response. Following T cell receptor activation and co-stimulation by antigen-presenting cells, naïve CD4<sup>+</sup> T cells differentiate into one of several lineages of T helper cell subtypes depending primarily on cytokines present in the extracellular environment. In the presence of IL-27 and IL-12, naïve CD4<sup>+</sup> T cells differentiate into T helper type 1 (Th1) cells. Th1 cells are required for host defense against intracellular viral and bacterial pathogens. IL-27 promotes early commitment to the Th1 lineage by activating STAT1 signaling to induce expression of the Th1-specific transcription factor, T-bet, and inhibit expression of the Th2-specific transcription factor, GATA-3. T-bet serves as the master regulator of Th1 differentiation. It promotes expression of both IL-12 R beta 2 and IFN-gamma, the signature cytokine produced by Th1 cells. IL-12 R beta 2 dimerizes with IL-12 R beta 1 to form a functional IL-12 receptor complex. This renders the cells responsive to IL-12, which is critical for Th1 differentiation. IL-12 signaling stimulates STAT4-dependent expression of IFN-gamma and IL-18 R beta. Formation of the IL-18 receptor complex allows IL-18 signaling to further drive IFN-gamma expression through AP-1-dependent transcription. In addition to activation of STAT4, IL-12, along with IFN-gamma, activates STAT1 to maintain T-bet expression and Th1-specific cytokine production.</p> <p>To learn more, please visit our <a href="/research-area/th1-cells">Th1 Cells Research Area</a>.</p> </p></div> <div id="print-copy-form" class="accordion-wrapper"> <h3 class="builder-header builder-bead-type ui-accordion-header ui-helper-reset ui-state-default ui-corner-all ui-accordion-icons" data-toggle="collapse" data-target="#collapsePathwayRequest" aria-expanded="false" id="pathwayRequestAccordionHeader"> <span class="ui-accordion-header-icon" id="accordionArrow"></span> Get Print Copy of this Pathway </h3> <div class="collapse" id="collapsePathwayRequest"> <div id="pathwayRequestWebformWrapper"> <form class="webform-client-form webform-client-form-27981" action="/pathways/th1-differentiation-pathway" method="post" id="webform-client-form-27981" accept-charset="UTF-8"><div><div class="form-item webform-component webform-component-textfield webform-component--first-name form-group form-item form-item-submitted-first-name form-type-textfield form-group"> <label class="control-label" for="edit-submitted-first-name">First Name <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" type="text" id="edit-submitted-first-name" name="submitted[first_name]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-textfield webform-component--last-name form-group form-item form-item-submitted-last-name form-type-textfield form-group"> <label class="control-label" for="edit-submitted-last-name">Last Name <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" type="text" id="edit-submitted-last-name" name="submitted[last_name]" value="" size="60" maxlength="128" /></div><div 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