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data-nav="trigger" data-nav-search data-nav-target="nav-search" href="/search.aspx"><span class="a11y-sr-only">Search</span></a> <div class="nav__primary__dropdown" data-nav="target" id="nav-search"> <p data-module="label-float"> <label for="site-search"> <span class="nav-search__label--desktop">What are you searching for?</span> <span class="nav-search__label--mobile">Search</span> </label> <input type="search" id="site-search" value=""> <button class="fat-button"><span class="a11y-sr-only">Submit</span></button> </p> </div> </li> </ul> </nav> </header>    <main class="site-main" id="main-content" tabindex="-1"> <div id="panelMainContent"> <section class="layout-columns"> <div class="layout-columns__sidebar -padding--horizontal -padding--vertical -background--blue"> <div class="layout-columns__sidebar__content"> <h1 class="sidebar-heading"> <span class="sidebar-heading__subheading">Topic</span>Colorectal Cancer </h1> </div> </div> <div class="layout-columns__main -padding--vertical -padding--horizontal"> <div class="layout-columns__main__content"> <ul class="content-tease__list"> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Featured</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=1531" itemprop="url"> Review: Pathways of Colorectal Carcinogenesis</a> </h3> <p itemprop="description"> <p></p> <p></p> <p>Dozens of different somatic mutations have been identified in colorectal tumors, but colorectal cancer appears to develop via one of only a few distinct pathways.</p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p></p> <p class="content-tease__related"> <a href="/digestive-health/topic.aspx?id=1040" itemprop="relatedLink">Bowel Disease</a>, <a href="/oncology/topic.aspx?id=1059" itemprop="relatedLink">Colorectal Cancer</a>, <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a>, <a href="/oncology/specialty.aspx?id=1008" itemprop="relatedLink">Oncology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2020-04-22" itemprop="datePublished">April 22, 2020</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Featured</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=1388" itemprop="url"> Review: Lifestyle Factors, Changes in Gut Microbiota Are Linked in Development of Colorectal Cancer</a> </h3> <p itemprop="description"> <p>Both diet, lifestyle and the gut microbiome have been implicated in colorectal tumorigenesis. Accumulating evidence suggests these two influences are related and may point the way to better prevention strategies.</p></p> <p class="content-tease__related"> <a href="/oncology/topic.aspx?id=1059" itemprop="relatedLink">Colorectal Cancer</a>, <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a>, <a href="/oncology/specialty.aspx?id=1008" itemprop="relatedLink">Oncology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2019-10-23" itemprop="datePublished">October 23, 2019</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Featured</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=1238" itemprop="url"> Fiber Intake Has Survival Benefit in Patients Already Diagnosed with Colorectal Cancer</a> </h3> <p itemprop="description"> <p>In the first prospective study of the topic, gastroenterologists and epidemiologists at Massachusetts General Hospital found that higher fiber intake after a diagnosis of nonmetastatic colorectal cancer is associated with longer survival.</p></p> <p class="content-tease__related"> <a href="/oncology/topic.aspx?id=1059" itemprop="relatedLink">Colorectal Cancer</a>, <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a>, <a href="/oncology/specialty.aspx?id=1008" itemprop="relatedLink">Oncology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2019-03-13" itemprop="datePublished">March 13, 2019</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/article-external.aspx?id=1169" itemprop="url"> Taking Aspirin Associated With Reduction in Colorectal Cancer Among High-Risk Population</a> </h3> <p itemprop="description"> <p>Massachusetts General Hospital researchers found that regular aspirin use was associated with the greatest reduction of colorectal cancer among those at the highest risk.</p></p> <p class="content-tease__related"> <a href="/oncology/topic.aspx?id=1059" itemprop="relatedLink">Colorectal Cancer</a>, <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a>, <a href="/oncology/specialty.aspx?id=1008" itemprop="relatedLink">Oncology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -article">Article</span> <time class="date" datetime="2024-09-11" itemprop="datePublished">September 11, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=2619" itemprop="url"> Post-Diagnosis Multivitamin Supplementation May Prolong Survival Among Patients With Nonmetastatic CRC</a> </h3> <p itemprop="description"> <p><span>Mingyang Song, MBBS, ScD, and colleagues present evidence that the benefit of multivitamin supplements may extend beyond primary prevention of colorectal cancer (CRC). They linked the use of three to five multivitamin tablets/week after diagnosis of nonmetastatic CRC to lower CRC-specific and overall mortality.</span></p></p> <p class="content-tease__related"> <a href="/oncology/topic.aspx?id=1059" itemprop="relatedLink">Colorectal Cancer</a>, <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a>, <a href="/oncology/specialty.aspx?id=1008" itemprop="relatedLink">Oncology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2024-05-09" itemprop="datePublished">May 9, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=2594" itemprop="url"> Vitamin C Might Have Clinical Benefit Against KRAS- and BRAF-mutated CRC</a> </h3> <p itemprop="description"> <p><span>Shuji Ogino, MD, PhD, Mingyang Song, MBBS, ScD, and colleagues leveraged data from two large, prospective U.S. studies that showed the use of vitamin C after diagnosis of colorectal cancer with KRAS or BRAF mutations was associated with a 26% reduction in the risk of disease-specific mortality.</span></p></p> <p class="content-tease__related"> <a href="/oncology/topic.aspx?id=1059" itemprop="relatedLink">Colorectal Cancer</a>, <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a>, <a href="/oncology/specialty.aspx?id=1008" itemprop="relatedLink">Oncology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2024-02-27" itemprop="datePublished">February 27, 2024</time> </p> </div> </li> </ui> <p class="fat-link__cta u-flush u-text-right"> <a class="fat-link -caret -large" href="https://advances.massgeneral.org/search.aspx?q=*&st=1&topic=colorectal%20cancer&maxResults=15">View All Colorectal Cancer Updates</a> </p> </div> </div> </section> <section class="-background--grey -padding--vertical -padding--horizontal"> <div class="content-container -width--wide -centered"> <h2 class="section-heading -centered">Mass General Cancer Center Contributors</h2> <ul class="profile-card__list" id="profile-cards"> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/daniel_chung_advances.png, /assets/images/contributors/daniel_chung_advances_2x.png 2x" src="/assets/images/contributors/daniel_chung_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1331" itemprop="url">Daniel C. Chung, MD</a> </h3> <p itemprop="jobTitle"> Medical Co-Director, Center for Cancer Risk Assessment, Director, High-Risk GI Cancer Clinic, Mass General Cancer Center, Professor of Medicine, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/digestive-health/journal.aspx?id=1999">Pilot Study: Virtual Reality Is a Feasible Alternative to Narcotics During Colonoscopy</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/daniel_chung_advances.png, /assets/images/contributors/daniel_chung_advances_2x.png 2x" src="/assets/images/contributors/daniel_chung_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="Dr. David Berger" itemprop="image" srcset="/assets/images/contributors/Berger_advances.png, /assets/images/contributors/Berger_advances_2x.png 2x" src="/assets/images/contributors/Berger_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1424" itemprop="url">David L. Berger, MD</a> </h3> <p itemprop="jobTitle"> Colorectal and Gastrointestinal Surgeon, Division of Gastrointestinal & Oncologic Surgery, Mass General, Associate Professor of Surgery, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/digestive-health/journal.aspx?id=2560">Likelihood of Death at Home Is Improving in Colorectal Cancer, but Sociodemographic Disparities Persist</a> </p> </div> <p class="profile-card__image"> <img alt="Dr. David Berger" itemprop="image" srcset="/assets/images/contributors/Berger_advances.png, /assets/images/contributors/Berger_advances_2x.png 2x" src="/assets/images/contributors/Berger_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1427" itemprop="url">Hiroko Kunitake, MD, MPH</a> </h3> <p itemprop="jobTitle"> Gastrointestinal and Colorectal Surgeon, Surgical Director, Perioperative Optimization of Senior Health (POSH) Clinic, Massachusetts General Hospital, Assistant Professor of Surgery, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/geriatrics/article.aspx?id=1538">New Multidisciplinary Clinic Aims to Improve Surgical Outcomes in Older Adults</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset=", 2x" src=""> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="Dr. Bordeianou" itemprop="image" srcset="/assets/images/contributors/GenGastroSurg_Lillian_Bordeianou_advances.png, /assets/images/contributors/GenGastroSurg_Lillian_Bordeianou_advances_2x.png 2x" src="/assets/images/contributors/GenGastroSurg_Lillian_Bordeianou_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1389" itemprop="url">Liliana G. Bordeianou, MD, MPH, FACS, FASCRS</a> </h3> <p itemprop="jobTitle"> Site Director of the Colorectal Surgery Program, Co-Director, Pelvic Floor Disorders Center, Mass General, Co-Chair, Mass General Brigham Colorectal Surgery Collaborative, Professor of Surgery, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/digestive-health/journal.aspx?id=2364">New Scoring System Allows Assessment of the Severity of Ileoanal Pouch Syndrome</a> </p> </div> <p class="profile-card__image"> <img alt="Dr. Bordeianou" itemprop="image" srcset="/assets/images/contributors/GenGastroSurg_Lillian_Bordeianou_advances.png, /assets/images/contributors/GenGastroSurg_Lillian_Bordeianou_advances_2x.png 2x" src="/assets/images/contributors/GenGastroSurg_Lillian_Bordeianou_advances.png"> </p> </li> </ul> </div> </section> <div class="content-container -width--xwide -centered specialty-block__wrapper" id="specialty-block"> <style> #specialty-block 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