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768px) { .mainBanner__txt br, .linkBox .elementor-icon-box-title br { display: none; } .growing-network .elementor-heading-title br { display: none; } } @media (max-width: 767px) { .txtLinkWI .elementor-icon-box-wrapper .elementor-icon-box-icon { margin: 0; margin-left: 15px !important; margin-top: 2px; } } /****__ Footer __****/ #menu-why-omniab, #menu-partnerships, #menu-contact, #menu-privacy-policy, #menu-disclaimer, #menu-about-us { font-weight: 700; } #nav_menu-12 { margin-bottom: 15px; } h2.widget-title { font-weight: 700; } .site-footer-section .menu li { margin-bottom: 10px; } .site-primary-footer-wrap.ast-builder-grid-row-2-lheavy .ast-builder-grid-row { grid-template-columns: 2.5fr 0.5fr; } .site-footer-primary-section-1 .footer-widget-area { display: flex; flex-wrap: wrap; } .site-footer-primary-section-1 .footer-widget-area > * { padding-right: 60px; } .site-footer-primary-section-1 #media_image-3 { flex: 1 0 100%; } .site-primary-footer-wrap .widget { margin-bottom: 30px; } .site-primary-footer-wrap .widget_text { margin-bottom: 0px; } .site-footer-primary-section-2 { padding-bottom: 25px; } .site-footer-below-section-2 { text-align: right; } .site-footer-below-section-2 .footer-widget-area .ast-header-html { display: inline-block; width: auto; } .site-below-footer-inner-wrap { border-top: 1px solid #fff; padding-top: 20px; } #nav_menu-6 .widget-title { line-height: 24px; } @media (max-width: 767px) { .site-primary-footer-wrap.ast-builder-grid-row-2-lheavy .ast-builder-grid-row { grid-template-columns: repeat(1, 12fr); } } @media (max-width: 540px) { .site-above-footer-inner-wrap .site-footer-section:not(:last-child) { margin-bottom: 25px !important; } .site-footer-above-section-2 .footer-widget-area .widget:not(:last-child), .site-footer-above-section-4 .footer-widget-area .widget:not(:last-child) { margin-bottom: 10px; } } /****__ Footer __/****/ @media (max-width: 1024px) { .mainBanner__heading br, .bInfo__col br { display: none; } } /****__ Tech page __****/ .absCell { transition: all 1s ease; transform: translate(-50%, -50%); } .objAnim .absCell { transform: unset; } .absCol--tech2.objAnim .absCell--1 { top: unset !important; left: unset !important; right: 80px; bottom: -80px; } .absCol--tech2.objAnim .absCell--2 { top: unset !important; left: 100px !important; bottom: 0px; } .absCol--tech2.objAnim .absCell--3 { left: 30px !important; top: -90px !important; } .absCol--tech2.objAnim .absCell--4 { left: unset !important; right: 80px; top: -140px !important; } .absCol--tech3.objAnim .absTCell--1 { top: -130px !important; left: -30px !important; } .absCol--tech3.objAnim .absTCell--2 { top: unset !important; left: unset !important; right: 10px; bottom: -60px } .absCol--tech3.objAnim .absTCell--3 { top: unset !important; left: unset !important; right: 185px; bottom: -110px } .absCol--tech4 .elementor-widget-wrap { min-height: 300px; width: 650px; max-width: 100%; margin-left: auto; margin-right: auto; } .absCol--tech4.objAnim .absCell--1 { top: -60px !important; left: 50px !important; } .absCol--tech4.objAnim .absCell--2 { top: unset !important; left: unset !important; right: 0; bottom: -80px; } .absCol--tech4.objAnim .absCell--3 { top: unset !important; left: 10px !important; bottom: -130px; } .absCol--tech5.objAnim .absTCell--1 { top: unset !important; left: unset !important; right: -20px; bottom: -80px; } .absCol--tech5.objAnim .absTCell--2 { top: -130px !important; left: -100px !important; } .absCol--tech5.objAnim .absTCell--3 { top: -140px !important; left: 100px !important; } /**_ Cells Animation _**/ @keyframes float { 0% { transform: translatey(0px); } 50% { transform: translatey(-20px); } 100% { transform: translatey(0px); } } @keyframes spin { 0% { transform: rotate(360deg); } 100% { transform: rotate(0deg); } } @-moz-keyframes spin { 0% { -moz-transform: rotate(360deg); } 100% { -moz-transform: rotate(0deg); } } @-webkit-keyframes spin { 0% {-webkit-transform: rotate(360deg); } 100% { -webkit-transform: rotate(0deg); } } @-o-keyframes spin { 0% { -o-transform: rotate(360deg); } 100% { -o-transform: rotate(0deg); } } .objAnim .absCell { animation: float 6s ease-in-out infinite; animation-delay: 1s; } /* .objAnim .absScreening { animation: spin 8s linear 0s infinite reverse; animation-delay: 1s; } */ /**_ Cells Animation _/**/ /**_ Scroll Snap _**/ /**_ Scroll Snap _**/ /**_ Responsive _**/ @media (max-width: 1366px) { .absCol--tech4.objAnim .absCell--1 { /* width: 320px; */ top: -70px !important; left: 0px !important; } .absCol--tech4.objAnim .absCell--2 { /* width: 390px; */ bottom: -50px !important; right: -40px !important; } .absCol--tech4.objAnim .absCell--3 { width: 290px; bottom: -60px !important; left: 50px !important; } .absCol--tech5.objAnim .absTCell--1 { width: 180px; right: 15px; bottom: -100px; } } @media (max-width: 1024px) { .omniLogos .elementor-widget-wrap { justify-content: flex-start !important; } .absCol--tech2.objAnim .absCell--1 { bottom: -90px !important; right: 20px !important; } .absCol--tech2.objAnim .absCell--4 { top: -140px !important; right: 20px !important; } .absCol--tech2.objAnim .absCell--2 { bottom: -20px !important; left: 20px !important; } .absCol--tech3.objAnim .absTCell--1 { top: -140px !important; left: -30px !important; } .absCol--tech3.objAnim .absTCell--2 { bottom: -90px !important; right: 0px !important; } .absCol--tech3.objAnim .absTCell--3 { bottom: -110px !important; right: 150px !important; } .absCol--tech4.objAnim .absCell--3 { bottom: -20px !important; left: 60px !important; } .absCol--tech5.objAnim .absTCell--1 { bottom: -100px !important; right: 30px !important; } .absCol--tech5.objAnim .absTCell--2 { top: -110px !important; left: 0px !important; } .absCol--tech5.objAnim .absTCell--3 { top: -130px !important; left: 150px !important; } } @media (max-width: 992px) { .scrollSnap { height: auto !important; } } @media (max-width: 768px) { .absCol--tech2.objAnim .absCell--1, .absCol--tech2.objAnim .absCell--3, .absCol--tech2.objAnim .absCell--4 { width: 140px !important; } .absCol--tech3.objAnim .absTCell--1, .absCol--tech3.objAnim .absTCell--2 { width: 110px !important; } .absCol--tech3.objAnim .absTCell--1 { top: -40px !important; left: -30px !important; } .absCol--tech4.objAnim .absCell--2 { width: 170px !important; } .absCol--tech5.objAnim .absTCell--1, .absCol--tech5.objAnim .absTCell--2 { width: 115px !important; } .absCol--tech5.objAnim .absTCell--1 { bottom: -50px !important; right: 30px !important; } .absCol--tech5.objAnim .absTCell--2 { top: -50px !important; left: 0px !important; } } @media (max-width:767px) { .absCell:not(.absScreening) { width: 130px !important; } .absCol--tech2.objAnim .absCell--1 { bottom: 0px !important; right: 120px !important; } .absCol--tech2.objAnim .absCell--2 { bottom: 20px !important; left: 120px !important; } .absCol--tech2.objAnim .absCell--3 { top: -50px !important; left: 60px !important; } .absCol--tech2.objAnim .absCell--4 { top: -50px !important; right: 60px !important; } .absCol--tech3.objAnim .absTCell--1 { width: 100px; top: -10px !important; left: 60px !important; } .absCol--tech3.objAnim .absTCell--2 { bottom: -60px !important; right: 10px !important; } .absCol--tech3.objAnim .absTCell--3 { bottom: -10px !important; right: unset !important; } .absCol--tech4 .elementor-widget-wrap { min-height: 300px; margin-left: auto; margin-right: auto; } .absCol--tech4.objAnim .absCell--1 { top: -60px !important; left: 200px !important; } .absCol--tech4.objAnim .absCell--2 { bottom: 20px !important; right: 120px !important; } .absCol--tech5.objAnim .absTCell--1 { bottom: -60px !important; right: 100px !important; } .absCol--tech5.objAnim .absTCell--2 { top: 20px !important; left: 30px !important; } .absCol--tech5.objAnim .absTCell--3 { top: -10px !important; right: 100px !important; } } @media (max-width: 480px) { .absCol--tech4 .elementor-widget-wrap { min-height: 200px; } .absCol--tech4.objAnim .absScreening { width: 120px !important; left: 30px !important; } .absCol--tech4.objAnim .absCell--2 { bottom: 20px !important; right: 80px !important; } .absCol--tech2.objAnim .absCell { width: 100px !important; } } @media (max-width: 411px) { .omniTechLogos__item { width: 50% !important; } .absCol--tech2.objAnim .absCell--2 { bottom: 20px !important; left: 20px !important; } } @media (max-width: 375px) { .absCol--tech2.objAnim .absCell, .absCol--tech5.objAnim .absCell { width: 80px !important; } .absCol--tech2.objAnim .absCell--2 { left: 10px !important; } } /**_ Responsive _/**/ /****__ Tech Page __/****/ /****__ Antibody Generation __****/ .pageMenu .menu { list-style-type: none; display: flex; margin: 0; padding: 0; flex-wrap: wrap; } .pageMenu .menu li { margin-right: 35px; } .pageMenu .menu li a { font-size: 20px; font-weight: 400; color: var(--e-global-color-primary); } .pageMenu .menu li a:hover, .pageMenu .menu li.current_page_item a { color: var(--e-global-color-0f09fdb); } .dOmni__txt.elementor-widget { margin-bottom: 0; } .dOmni__txt p:last-child { margin-bottom: 0; } .dOmni__inner .elementor-container { flex-wrap: wrap; } .dOmni__inner .elementor-container .dOmni__col { width: 33.33% !important; } @media (max-width: 1024px) { .pageMenu .menu li a { font-size: 18px; } .dOmni__inner .elementor-container .dOmni__col { width: 50% !important; } .dOmni__col--4 .dOmni__title .elementor-widget-container { margin-top: 15px !important; } .mTextShadow .elementor-heading-title { text-shadow: 0 0 20px rgb(0 0 0 / 50%); } } @media (max-width: 767px) { .dOmni__inner .elementor-container .dOmni__col { width: 100% !important; } .pageMenu .menu li { margin-right: 12px; line-height: 26px; } .pageMenu .menu li a { font-size: 16px; } .wBr br { display: none; } } /****__ Antibody Generation __/****/ .elementor-icon-list-icon { line-height: 19px; } /****__ Form __****/ .formField { margin-bottom: 30px; } .formField .wpcf7-form-control-wrap { margin-top: 10px; } .formField--dd .inquiry-dropdown { background: transparent; } .formField--dd .inquiry-dropdown:focus { border-color: var(--e-global-color-secondary); } /****__ Form __/****/ .post-template-default .site-content, .blog .site-content, .broadcast-template-default .site-content { padding: 200px 0 80px; } .post-template-default .site-header, .blog .site-header, .archive .site-header, .error404 .site-header, .broadcast-template-default .site-header, .search .site-header { background-color: #09163a; } @media (max-width: 920px) { .post-template-default .site-content, .blog .site-content, .broadcast-template-default .site-content { padding-top: 150px; } } /****__ About-us link boxe __****/ .aboutLinks__box .elementor-icon-box-title { margin-bottom: 0; } .aboutLinks__box { position: static; } .aboutLinks .elementor-widget-wrap { position: relative; } .aboutLinks__box .elementor-icon:before { content: ""; position: absolute; left: 0; top: 0; width: 100%; height: 100%; } .aboutLinks__box .elementor-icon-box-content { position: relative; } .aboutLinks .elementor-icon-box-content a { display: inline-block; width: 100%; } .aboutLinks .elementor-widget-wrap:hover .elementor-icon-box-content a { color: var(--e-global-color-secondary); } .aboutLinks__box .elementor-icon-box-icon { margin-top: 6px; } .aboutLinks .elementor-icon-box-icon { position: absolute; top: 0; left: 0; width: 100%; height: 100%; display: flex; justify-content: flex-end; align-items: flex-end; margin: 0 !important; padding: 30px; } /****__ About-us link box __/****/ .elementor-heading-title a:hover { color: var(--e-global-color-secondary) !important; } /****__ Posts __****/ .entry-header .entry-title { font-weight: 700; } /****__ Posts __/****/ @media (max-width: 1366px) { .elementor-container { padding-left: 4px; padding-right: 4px; } } @media (max-width: 1280px) { .elementor-container { padding-left: 10px; padding-right: 10px; } } .rPost__col .rPost__icon { width: 100px !important; height: 62px; } .rPost__col .rPost__cont { width: calc(100% - 100px); } .rPost__col .rPost__cont .elementor-widget-wrap { padding: 0; } .rPost__col .rPost__content .ae-element-post-read-more a:before { content: "\f04b"; font-family: "Font Awesome 5 Free"; font-weight: 900; -moz-osx-font-smoothing: grayscale; -webkit-font-smoothing: antialiased; display: inline-block; font-style: normal; font-variant: normal; text-rendering: auto; line-height: 1; } .rPost__content .elementor-widget-wrap { flex-wrap: unset; } .rPost__content .rPost__title { margin-bottom: 0; -webkit-box-flex: 1; -ms-flex-positive: 1; flex-grow: 1; width: auto; position: relative; z-index: 1; } .rPost__content .elementor-widget-wrap .rPost__readmore { align-items: flex-end; display: -webkit-inline-box; display: -ms-inline-flexbox; display: inline-flex; -webkit-box-flex: 0; -ms-flex: 0 1 auto; flex: 0 1 auto; width: auto; } .rPost__content .elementor-widget-wrap .rPost__readmore a { padding: 0; line-height: 20px; color: var(--e-global-color-0f09fdb); } .rPost__content .ae-element-post-title { transition: all 0.4s ease; margin-bottom: 0; } .rPost__content .elementor-widget-wrap, .rPost__content, .rPost__col .rPost__cont, .rPost__content .elementor-widget-wrap .rPost__readmore, .rPost__cont .elementor-container { position: static; } .rPost__content .elementor-widget-wrap .rPost__readmore a:after { content: ""; width: 100%; height: 100%; position: absolute; left: 0; top: 0; } .rPost__col:hover .ae-element-post-title { color: var(--e-global-color-secondary); } .rPost__cont > .elementor-container { padding: 0; } .ae-post-collection .ae-post-item-inner { overflow: unset !important; } @media (max-width: 767px) { .rPost__col .rPost__icon { width: 70px !important; padding-right: 15px; } .rPost__col .rPost__cont { width: calc(100% - 70px); } } @media (max-width: 480px) { .rPost__col .rPost__cont .elementor-widget-wrap { display: block; } .rPost__content .elementor-widget-wrap .rPost__readmore { text-align: right; margin-top: 10px; display: block; } .linkBox2 .elementor-icon-box-icon { margin: 0 !important; margin-top: 15px !important; justify-content: flex-end; } .linkBox2 .elementor-icon-box-wrapper { flex-wrap: wrap; flex-direction: column-reverse; } } /****__ Pipeline Image __****/ @media (max-width: 992px) { .omniabPipeline .elementor-widget-container { overflow-x: auto; } .omniabPipeline .elementor-widget-container img { width: 1000px; max-width: unset; } } /****__ Pipeline Image __/****/ .site-above-footer-wrap { display: none !important; } @media (min-width: 768px) { .main-header-menu .sub-menu .menu-item#menu-item-9856:hover>.sub-menu, .main-header-menu .sub-menu .menu-item#menu-item-9861:hover>.sub-menu { left: auto; right: 100%; } } .d-none { display: none !important; } /* PORTFOLIO 1-OFF BAR EDIT STARTS */ #portfolio-table tbody > tr:nth-child(4) .phaseBarContainer { padding-right: 90px; } /* PORTFOLIO 1-OFF BAR EDIT ENDS */ body.page-id-9 .last-logo-row > div { -webkit-box-pack: center; -ms-flex-pack: center; justify-content: center; -ms-flex-wrap: wrap; flex-wrap: wrap; } body.page-id-9 .last-logo-row > div > div { width: 100% !important; } @media (min-width: 768px) { body.page-id-9 .last-logo-row > div > div { width: 25% !important; } } .footer-social-item { border-radius: 50%; } </style> </head> <body itemtype='https://schema.org/WebPage' itemscope='itemscope' class="page-template-default page page-id-27 page-parent page-child parent-pageid-9 wp-custom-logo ast-desktop ast-page-builder-template ast-no-sidebar astra-4.8.0 group-blog ast-single-post ast-inherit-site-logo-transparent ast-theme-transparent-header ast-hfb-header elementor-default elementor-kit-5 elementor-page elementor-page-27"> <a class="skip-link screen-reader-text" href="#content" role="link" title="Skip to content"> Skip to content</a> <div class="hfeed site" id="page"> <header class="site-header header-main-layout-1 ast-primary-menu-enabled ast-logo-title-inline ast-hide-custom-menu-mobile ast-builder-menu-toggle-icon ast-mobile-header-inline" id="masthead" itemtype="https://schema.org/WPHeader" itemscope="itemscope" itemid="#masthead" > <div id="ast-desktop-header" data-toggle-type="dropdown"> <div class="ast-main-header-wrap main-header-bar-wrap "> <div class="ast-primary-header-bar ast-primary-header main-header-bar site-header-focus-item" data-section="section-primary-header-builder"> <div class="site-primary-header-wrap ast-builder-grid-row-container site-header-focus-item ast-container" data-section="section-primary-header-builder"> <div class="ast-builder-grid-row ast-builder-grid-row-has-sides ast-builder-grid-row-no-center"> <div class="site-header-primary-section-left site-header-section ast-flex site-header-section-left"> <div class="ast-builder-layout-element ast-flex site-header-focus-item" data-section="title_tagline"> <div class="site-branding ast-site-identity" itemtype="https://schema.org/Organization" itemscope="itemscope" > <span class="site-logo-img"><a href="https://www.omniab.com/" class="custom-logo-link" rel="home"><img width="262" height="59" src="https://www.omniab.com/wp-content/uploads/2021/08/OmniLogo-Small.png" class="custom-logo" alt="OmniAb" decoding="async" /></a></span> </div>  </div> </div> <div class="site-header-primary-section-right site-header-section ast-flex ast-grid-right-section"> <div class="ast-builder-menu-1 ast-builder-menu ast-flex ast-builder-menu-1-focus-item ast-builder-layout-element site-header-focus-item" data-section="section-hb-menu-1"> <div class="ast-main-header-bar-alignment"><div class="main-header-bar-navigation"><nav class="site-navigation ast-flex-grow-1 navigation-accessibility site-header-focus-item" id="primary-site-navigation-desktop" aria-label="Site Navigation: Main" itemtype="https://schema.org/SiteNavigationElement" itemscope="itemscope"><div class="main-navigation ast-inline-flex"><ul id="ast-hf-menu-1" class="main-header-menu ast-menu-shadow ast-nav-menu ast-flex submenu-with-border stack-on-mobile"><li id="menu-item-3973" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-3973"><a aria-expanded="false" href="#" class="menu-link">About<span role="application" class="dropdown-menu-toggle ast-header-navigation-arrow" tabindex="0" aria-expanded="false" aria-label="Menu Toggle" ><span class="ast-icon icon-arrow"><svg class="ast-arrow-svg" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" version="1.1" x="0px" y="0px" width="26px" height="16.043px" viewBox="57 35.171 26 16.043" enable-background="new 57 35.171 26 16.043" xml:space="preserve"> <path d="M57.5,38.193l12.5,12.5l12.5-12.5l-2.5-2.5l-10,10l-10-10L57.5,38.193z"/> </svg></span></span></a><button class="ast-menu-toggle" aria-expanded="false"><span class="screen-reader-text">Menu Toggle</span><span class="ast-icon icon-arrow"><svg class="ast-arrow-svg" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" version="1.1" x="0px" y="0px" width="26px" height="16.043px" viewBox="57 35.171 26 16.043" enable-background="new 57 35.171 26 16.043" xml:space="preserve"> <path d="M57.5,38.193l12.5,12.5l12.5-12.5l-2.5-2.5l-10,10l-10-10L57.5,38.193z"/> </svg></span></button> <ul class="sub-menu"> <li id="menu-item-1730" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1730"><a href="https://www.omniab.com/about-us/management-team/" class="menu-link"><span class="ast-icon icon-arrow"><svg class="ast-arrow-svg" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" version="1.1" x="0px" y="0px" width="26px" height="16.043px" viewBox="57 35.171 26 16.043" enable-background="new 57 35.171 26 16.043" xml:space="preserve"> <path d="M57.5,38.193l12.5,12.5l12.5-12.5l-2.5-2.5l-10,10l-10-10L57.5,38.193z"/> </svg></span>Team</a></li> <li id="menu-item-9677" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-9677"><a href="https://www.omniab.com/about-us/board-of-directors/" class="menu-link"><span class="ast-icon icon-arrow"><svg class="ast-arrow-svg" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" version="1.1" x="0px" y="0px" width="26px" height="16.043px" viewBox="57 35.171 26 16.043" enable-background="new 57 35.171 26 16.043" xml:space="preserve"> <path d="M57.5,38.193l12.5,12.5l12.5-12.5l-2.5-2.5l-10,10l-10-10L57.5,38.193z"/> </svg></span>Board of Directors</a></li> <li id="menu-item-15362" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-15362"><a href="https://www.omniab.com/about-us/careers/" class="menu-link"><span class="ast-icon icon-arrow"><svg class="ast-arrow-svg" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" version="1.1" x="0px" y="0px" width="26px" height="16.043px" viewBox="57 35.171 26 16.043" enable-background="new 57 35.171 26 16.043" xml:space="preserve"> <path 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<div class="elementor-background-overlay"></div> <div class="elementor-container elementor-column-gap-default"> <div class="has_ae_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-1f1bc24d ae-bg-gallery-type-default" data-id="1f1bc24d" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-18a855db pageBanner__heading mTextShadow elementor-widget elementor-widget-heading" data-id="18a855db" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h1 class="elementor-heading-title elementor-size-default">Antibody Optimization </h1> </div> </div> </div> </div> <div class="has_ae_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-3cb8631a ae-bg-gallery-type-default" data-id="3cb8631a" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> </div> </section> <section class="has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-8c24a75 pageMenu-wrap elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default" data-id="8c24a75" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="has_ae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7d27095 ae-bg-gallery-type-default" data-id="7d27095" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-e332482 pageMenu elementor-widget-tablet__width-auto elementor-widget elementor-widget-wp-widget-nav_menu" data-id="e332482" data-element_type="widget" data-widget_type="wp-widget-nav_menu.default"> <div class="elementor-widget-container"> <nav class="menu-antibody-optimization-container" aria-label="Menu"><ul id="menu-antibody-optimization" class="menu"><li id="menu-item-11472" class="menu-item menu-item-type-post_type menu-item-object-page current-menu-item page_item page-item-27 current_page_item menu-item-11472"><a href="https://www.omniab.com/technology/optimization/" aria-current="page" class="menu-link">Antibody Optimization</a></li> <li id="menu-item-11470" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-11470"><a href="https://www.omniab.com/technology/optimization/fc-silencing-technology/" class="menu-link">Fc-Silencing Technology</a></li> </ul></nav> </div> </div> </div> </div> </div> </section> <section class="has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-5be78cd0 agOverview elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default" data-id="5be78cd0" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="has_ae_slider elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-75768298 agOverview__col agOverview__col--1 ae-bg-gallery-type-default" data-id="75768298" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-1b418073 elementor-widget elementor-widget-heading" data-id="1b418073" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Naturally optimized human antibodies<sup>庐</sup></h2> </div> </div> <div class="elementor-element elementor-element-75890b69 agOverview__txt elementor-widget elementor-widget-text-editor" data-id="75890b69" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>The in vivo immune response pairs intrinsic genetic diversification mechanisms with powerful cellular selection to generate diverse antibody repertoires directed against virtually any type of protein target. Many iterations of mutation and selection result in rapid molecular evolution that efficiently samples vast sequence space to generate antibodies with optimal binding characteristics. When this natural process takes place in animals that have been engineered to harbor human Ig transgenes, it creates a facile and versatile path to therapeutic agents capable of addressing a wide variety of human disease.</p> </div> </div> </div> </div> <div class="has_ae_slider elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-1af27ce2 ae-bg-gallery-type-default" data-id="1af27ce2" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-33eb4bd elementor-invisible elementor-widget elementor-widget-image" data-id="33eb4bd" data-element_type="widget" data-settings="{"_animation":"fadeInRight"}" data-widget_type="image.default"> <div class="elementor-widget-container"> <img fetchpriority="high" decoding="async" width="1024" height="683" src="https://www.omniab.com/wp-content/uploads/2024/04/NRB3011-1024x683.jpg" class="attachment-large size-large wp-image-15043" alt="Durham Lab" srcset="https://www.omniab.com/wp-content/uploads/2024/04/NRB3011-1024x683.jpg 1024w, https://www.omniab.com/wp-content/uploads/2024/04/NRB3011-300x200.jpg 300w, https://www.omniab.com/wp-content/uploads/2024/04/NRB3011-768x512.jpg 768w, https://www.omniab.com/wp-content/uploads/2024/04/NRB3011-1536x1024.jpg 1536w, https://www.omniab.com/wp-content/uploads/2024/04/NRB3011-scaled.jpg 2048w" sizes="(max-width: 1024px) 100vw, 1024px" /> </div> </div> </div> </div> </div> </section> <section class="has_ae_slider elementor-section elementor-top-section elementor-element elementor-element-7df7975 elementor-section-boxed elementor-section-height-default elementor-section-height-default ae-bg-gallery-type-default" data-id="7df7975" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="has_ae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d93dc0f ae-bg-gallery-type-default" data-id="d93dc0f" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-5245e7e elementor-widget elementor-widget-heading" data-id="5245e7e" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Phenotypic Sampling of the Immune Repertoire</h2> </div> </div> <div class="elementor-element elementor-element-716ea9f elementor-widget elementor-widget-text-editor" data-id="716ea9f" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Antibodies of interest can be identified in immunized animals using <a href="/technology/screening/">single B-cell screening</a> methods, which allow phenotypic characterization of mAbs secreted by individual cells. This allows for the selective recovery of desired mAb clones and efficient sampling of an immune repertoire, and is particularly useful when evaluating immunization strategies and response differences between individual animals in a campaign. When large numbers of clones are obtained it is possible to correlate antibody performance profiles with particular sequences (clonotypes).</p> </div> </div> <div class="elementor-element elementor-element-c57fbce elementor-widget elementor-widget-heading" data-id="c57fbce" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Diving Deeper into Immune Repertoires</h2> </div> </div> <div class="elementor-element elementor-element-b7dc813 elementor-widget elementor-widget-text-editor" data-id="b7dc813" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>When phenotypic screening reveals one or more clonotypes with favorable therapeutic potential, it is possible to further expand the pool of candidates by performing additional phenotypic screening focused on selected antibody repertoires. Additionally, it is possible to use the phenotypic data and chain pairing information to leverage NGS data sets to explore entire antibody repertoires to find highly related sequences that may have been missed in phenotypic screening.</p> </div> </div> <div class="elementor-element elementor-element-27560e9 elementor-widget elementor-widget-heading" data-id="27560e9" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Identifying Therapeutic Leads</h2> </div> </div> <div class="elementor-element elementor-element-a2b767f elementor-widget elementor-widget-text-editor" data-id="a2b767f" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Through phenotypic screening and hit expansion, a large number of variant sequences can be discovered for each clonotype determined to have therapeutic potential. These sequences are filtered through a battery of in silico evaluations to remove sequences with liabilities or potential developability problems, and potentially improve potency. Naturally optimized sequences are then re-expressed in antibody format of choice and performance is confirmed in analytical and bioassay evaluation to create a ranked list of potential leads. </p> </div> </div> </div> </div> </div> </section> </div> </div> </article> </main> </div> </div>  </div> <footer class="site-footer" id="colophon" itemtype="https://schema.org/WPFooter" itemscope="itemscope" itemid="#colophon"> <div class="site-above-footer-wrap ast-builder-grid-row-container site-footer-focus-item ast-builder-grid-row-4-equal ast-builder-grid-row-tablet-4-equal ast-builder-grid-row-mobile-full ast-footer-row-stack ast-footer-row-tablet-stack ast-footer-row-mobile-stack" data-section="section-above-footer-builder"> <div class="ast-builder-grid-row-container-inner"> <div class="ast-builder-footer-grid-columns site-above-footer-inner-wrap ast-builder-grid-row"> <div class="site-footer-above-section-1 site-footer-section site-footer-section-1"> <div class="footer-widget-area widget-area site-footer-focus-item ast-footer-html-1" data-section="section-fb-html-1"> <div class="ast-header-html inner-link-style-"><div class="ast-builder-html-element"><p><strong>About</strong></p> </div></div> </div> <div class="footer-widget-area widget-area site-footer-focus-item" data-section="section-footer-menu"> <div class="footer-bar-navigation"><nav class="site-navigation ast-flex-grow-1 navigation-accessibility footer-navigation" id="footer-site-navigation" aria-label="Site Navigation: About pages" itemtype="https://schema.org/SiteNavigationElement" itemscope="itemscope"><div class="footer-nav-wrap"><ul id="astra-footer-menu" class="ast-nav-menu ast-flex astra-footer-vertical-menu astra-footer-tablet-vertical-menu astra-footer-mobile-vertical-menu"><li id="menu-item-1735" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1735"><a href="https://www.omniab.com/about-us/management-team/" class="menu-link">Team</a></li> <li id="menu-item-9871" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-9871"><a href="https://www.omniab.com/about-us/board-of-directors/" class="menu-link">Board of Directors</a></li> <li id="menu-item-15367" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-15367"><a href="https://www.omniab.com/about-us/careers/" class="menu-link">Careers</a></li> </ul></div></nav></div> </div> </div> <div class="site-footer-above-section-2 site-footer-section site-footer-section-2"> <aside class="footer-widget-area widget-area site-footer-focus-item footer-widget-area-inner" data-section="sidebar-widgets-footer-widget-1" aria-label="Footer Widget 1" > <section id="block-14" class="widget widget_block"><section id="block-13" class="widget widget_block"> <h2 style=" color: #fff; 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