Translating Discoveries into Effective Devices to Treat Pain

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class="breadcrumb"> <li class="breadcrumb-item gtm-breadcrumb"><a href="/" class="gtm-breadcrumb">Home</a></li> <li class="breadcrumb-item gtm-breadcrumb"><a href="/research" class="gtm-breadcrumb">Research</a></li> <li class="breadcrumb-item gtm-breadcrumb"><a href="/research/preclinical-translational" class="gtm-breadcrumb">Preclinical and Translational Research In Pain Management</a></li> <li class="breadcrumb-item active is-active gtm-breadcrumb" aria-current="page">Translating Discoveries into Effective Devices to Treat Pain</li> </ol> </nav> </div> </div> <div class="col-sm-12 col-md-5"> </div> </div> </div> <div class="layout-content"> <div> <div id="block-particle-content"> <h1> Translating Discoveries into Effective Devices to Treat Pain </h1> <div> <div class="paragraph paragraph--type--content-and-view paragraph--view-mode--default"> <div class="container"> <div class="pattern"> <div class='row'> <div> <div class="col-12 col-xl-6 float-right"> <div class="views-element-container form-group"><div class="carousel-view js-view-dom-id-bd044d0ccc88a29e2084389d5e50a1f1b0e75b63daee99074787c0595fc25189"> <div id="carousel-573871909" class="callout carousel slide" data-ride="carousel"> <button type=button class="btn carousel-pause" target="" > <span class="pause-icon"></span> </button> <button type=button class="btn carousel-play" target="" > <span class="play-icon"></span> </button> <ol class="carousel-indicators"> <li data-target="#carousel-573871909" data-slide-to="0" class="active"></li> <li data-target="#carousel-573871909" data-slide-to="1" class=""></li> <li data-target="#carousel-573871909" data-slide-to="2" class=""></li> </ol> <div class="carousel-inner"> <p><strong>Research Spotlights</strong></p> <div class="carousel-item active"> <span class="carousel-item-container"> <div class="card overlay-body" id="finding-new-options-for-sickle-cell-disease-pain"> <a href="/news/stories/new-options-sickle-cell-disease-pain" aria-label="Finding New Options for Sickle Cell Disease Pain"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/sickle-cell-landing-page.jpg?itok=K5u97IEp" width="900" height="507" alt="woman sitting in a chair looking at a laptop and wearing headphones" class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/new-options-sickle-cell-disease-pain"> Finding New Options for Sickle Cell Disease Pain </a> </p> </div> </div> </div> </div> </span> </div> <div class="carousel-item "> <span class="carousel-item-container"> <div class="card overlay-body" id="next-gen-device-could-relieve-phantom-limb-pain"> <a href="/news/stories/phantom-limb-pain" aria-label="Next-gen Device Could Relieve Phantom Limb Pain"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/Peripheral%20Nerve%20Stimulator%20System.jpg?itok=4o6yyK3f" width="900" height="507" alt="Illustration of a device that stimulates the nerves and alleviates phantom limb pain." class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/phantom-limb-pain"> Next-gen Device Could Relieve Phantom Limb Pain </a> </p> </div> </div> </div> </div> </span> </div> <div class="carousel-item "> <span class="carousel-item-container"> <div class="card overlay-body" id="nerve-stimulation-helps-manage-pain-without-opioids"> <a href="/news/stories/nerve-stimulation" aria-label="Nerve Stimulation Helps Manage Pain Without Opioids"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/nerve%20stim.small_.png?itok=aSTmTHrt" width="900" height="507" alt="Image of a nerve stimulator, a kind of electrode, being applied. " class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/nerve-stimulation"> Nerve Stimulation Helps Manage Pain Without Opioids </a> </p> </div> </div> </div> </div> </span> </div> <a class="carousel-control-prev" href="#carousel-573871909" role="button" data-slide="prev"> <span class="carousel-control-prev-icon" aria-hidden="true"> <span class="angle-left-icon"></span> </span> <span class="sr-only">Previous</span> </a> <a class="carousel-control-next" href="#carousel-573871909" role="button" data-slide="next"> <span class="carousel-control-next-icon" aria-hidden="true"> <span class="angle-right-icon"></span> </span> </span> <span class="sr-only">Next</span> </a> </div> </div> </div> </div> </div> <p class='col-12'> <h2>Overview </h2><h3>The Research Need </h3><p>Opioid misuse is a major factor in the development of opioid use disorder. Advances in technology show promise for identifying new, safer pain management options to improve quality of life and reduce reliance on opioids. Innovative technology designs may also reduce side effects compared to medication-based strategies. Several effective devices for pain have already received approval or clearance from the U.S. Food and Drug Administration.</p><h3>About the Program </h3><p>This program fosters the development of next-generation medical devices to diagnose and treat both pain and opioid use disorder. The research supports preclinical development and translational research efforts to advance promising technologies to readiness for testing in clinical trials.</p><p>The program also promotes development of groundbreaking, safe, and effective medical devices via the NIH Blueprint MedTech incubator program. This program supports and de-risks the development of medical devices targeting nervous system disorders, including chronic pain and opioid use disorder, from early development stages through first-in-human clinical trials.</p><p>Another focus of the program is to support interdisciplinary team science and academic-industry partnerships to understand how medical devices work to relieve pain. This new body of knowledge will uncover new pain biomarkers and optimize clinical approaches to enhance pain relief for patients.</p> </p> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default"> <div class='container'> <div class="dynamic_content"> <div class="views-element-container form-group"><div class="viewsreference--view-title"> </div> <div class="js-view-dom-id-466a5cf55451f5011392650460361358327ab618cb590f798824c1b48860f753"> <h2>Open Funding Opportunities</h2> <div class="pattern"> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2022 </div> <div class="col-lg-6 col-md-12"> HEAL Initiative: Translational Development of Diagnostic and Therapeutic Devices (R18 Clinical Trial Not Allowed) </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=https://grants.nih.gov/grants/guide/rfa-files/rfa-eb-22-002.html> NOFO Link </a> </div> <div class="col-6 d-lg-none"> Aug 23, 2022 </div> <div class="col-6 d-lg-none"> <a href="https://grants.nih.gov/grants/guide/rfa-files/rfa-eb-22-002.html">NOFO Link</a> </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2023 </div> <div class="col-lg-6 col-md-12"> HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional) </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=https://grants.nih.gov/grants/guide/rfa-files/rfa-ns-23-028.html> NOFO Link </a> </div> <div class="col-6 d-lg-none"> Apr 27, 2023 </div> <div class="col-6 d-lg-none"> <a href="https://grants.nih.gov/grants/guide/rfa-files/rfa-ns-23-028.html">NOFO Link</a> </div> </div> </div> <div style="text-align:right;"> <a class="btn btn-primary" target="" href=/funding/open?research_program=201> View all </a> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--basic-content paragraph--view-mode--default"> <div class="container"> <div class='basic-content content-align-left pattern'> <div class='basic-content-grid-container ' style=''> <h2 class='basic-content-grid-h2-no-media'> Program Details </h2> <div class="basic-content-grid-no-media"> <div> <p>To date, through the Helping to End Addiction Long-term<sup>®</sup> Initiative, or NIH HEAL Initiative<sup>®</sup>, NIH has contributed $51.5 million to fund this program, which has funded 18 awards.</p> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--basic-content paragraph--view-mode--default"> <div class="container"> <div class='basic-content content-align-left pattern'> <div class='basic-content-grid-container ' style=''> <h2 class='basic-content-grid-h2-no-media'> Research Examples </h2> <div class="basic-content-grid-no-media"> <div> <p>Research examples supported by this program include: </p><ul><li>Developing an injectable electrode to be inserted into the spinal cord to treat chronic back pain</li><li>Using image-guided technologies such as magnetic resonance imaging (MRI) or electroencephalograms to aim focused ultrasound at specific brain regions to interrupt pain circuits related to chronic pain conditions, such as sickle cell disease pain</li><li>Developing a non-invasive electroacupuncture device to treat pain associated with irritable bowel syndrome</li><li>Developing nanoparticles for intravenous delivery of ketamine using focused ultrasound in specific regions of the brain to treat chronic osteoarthritic pain while avoiding off-target effects</li><li>Using MRI-guided, focused ultrasound to treat head and neck cancer pain</li><li>Using multisite, closed-loop deep brain stimulation to treat chronic neuropathic pain</li><li>Conducting a mechanistic clinical trial to uncover mechanisms underlying pain relief by transcutaneous auricular neurostimulation</li><li>Developing and validating pain-associated outcome measures in non-rodent mammalian models</li></ul> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--accordion paragraph--view-mode--default"> <div class="container"> <div class="pattern"> <div id="accordion-1032660630" class="col-12 accordion"> <div class="card-header col-12" id="heading-1032660630-0"> <h2 class="mb-0"> <button class="btn btn-link h2 expand-link" data-toggle="collapse" data-target="#collapse-1032660630-0" aria-expanded="false" aria-controls="collapse-1032660630-0"> Funded Institutions and Locations </button> </h2> </div> <div id="collapse-1032660630-0" class="collapse " aria-labelledby="heading-1032660630-0" data-parent="#accordion-1032660630"> <div class="card-body"> <ul><li><strong>Baylor College of Medicine </strong>– Texas</li><li><strong>Carnegie-Mellon University</strong> – Pennsylvania</li><li><strong>Duke University</strong> – North Carolina</li><li><strong>Massachusetts General Hospital</strong> – Massachusetts</li><li><strong>Micro-Leads, Inc.</strong> – Massachusetts</li><li><strong>Novaflux, Inc.</strong> – New Jersey</li><li><strong>Ripple, LLC</strong> – Utah</li><li><strong>Stanford University</strong> – California</li><li><strong>University of California, Los Angeles</strong> – California</li><li><strong>University of California, San Francisco</strong> – California</li><li><strong>University of Michigan </strong>– Michigan</li><li><strong>University of Pittsburgh</strong> – Pennsylvania</li><li><strong>University of Texas Medical Branch</strong> – Texas</li><li><strong>University of Utah</strong> - Utah</li><li><strong>University of Virginia</strong> – Virginia</li><li><strong>University of Wisconsin–Madison</strong> – Wisconsin</li><li><strong>Vanderbilt University Medical Center</strong> – Tennessee</li></ul> </div> </div> </div> <div id="accordion-1536298949" class="col-12 accordion"> <div class="card-header col-12" id="heading-1536298949-1"> <h2 class="mb-0"> <button class="btn btn-link h2 expand-link" data-toggle="collapse" data-target="#collapse-1536298949-1" aria-expanded="false" aria-controls="collapse-1536298949-1"> Funded Projects </button> </h2> </div> <div id="collapse-1536298949-1" class="collapse " aria-labelledby="heading-1536298949-1" data-parent="#accordion-1536298949"> <div class="card-body"> <div class="views-element-container form-group"><div class="viewsreference--view-title"> </div> <div class="js-view-dom-id-81d88effc4d4a9219aab5052b81a65f519ca110f74e4b513a2071f415fbc2b7f"> <div class="pattern"> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2024 </div> <div class="col-lg-6 col-md-12"> NeuroTech Harbor: Our nation's first equitech ecosystem for neuromedical technologies </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=/funding/awarded?research_program=201#project-title-46976> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=201#project-title-46976">Summary</a> </div> <div class="col-6 d-lg-none"> Nov 24, 2024 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2024 </div> <div class="col-lg-6 col-md-12"> Discovery of Biomarker Signatures Prognostic for Neuropathic Pain after Acute Spinal Cord Injury </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=/funding/awarded?research_program=201#project-title-46981> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=201#project-title-46981">Summary</a> </div> <div class="col-6 d-lg-none"> Nov 24, 2024 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2024 </div> <div class="col-lg-6 col-md-12"> An innovative device for management of neuropathic pain after spinal cord injury </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=/funding/awarded?research_program=201#project-title-46971> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=201#project-title-46971">Summary</a> </div> <div class="col-6 d-lg-none"> Nov 24, 2024 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2024 </div> <div class="col-lg-6 col-md-12"> Transspinal Magnetic Stimulation for the Treatment of Neuropathic Pain </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=/funding/awarded?research_program=201#project-title-47331> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=201#project-title-47331">Summary</a> </div> <div class="col-6 d-lg-none"> Nov 24, 2024 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2023 </div> <div class="col-lg-6 col-md-12"> Translating an MR-guided focused ultrasound system for first-in-human precision neuromodulation of pain circuits </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=/funding/awarded?research_program=201#project-title-46271> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=201#project-title-46271">Summary</a> </div> <div class="col-6 d-lg-none"> Nov 28, 2023 </div> </div> </div> <div style="text-align:right;"> <a class="btn btn-primary" target="" href=/funding/awarded?research_program=201> View all </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--basic-content paragraph--view-mode--default"> <div class="container"> <div class='basic-content content-align-left pattern'> <div class='basic-content-grid-container ' style=''> <h2 class='basic-content-grid-h2-no-media'> Participating NIH Institutes, Centers, and Offices </h2> <div class="basic-content-grid-no-media"> <div> <ul><li><a href="https://www.cancer.gov/">National Cancer Institute (NCI)</a> </li><li><a href="https://ncats.nih.gov/">National Center for Advancing Translational Sciences (NCATS)</a> </li><li><a href="https://nccih.nih.gov/">National Center for Complementary and Integrative Health (NCCIH)</a> </li><li><a href="https://www.nei.nih.gov/">National Eye Institute (NEI) </a></li><li><a href="https://www.niams.nih.gov/">National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)</a> </li><li><a href="https://www.nibib.nih.gov/">National Institute of Biomedical Imaging and Bioengineering (NIBIB)</a> </li><li><a href="https://www.nidcr.nih.gov/">National Institute of Dental and Craniofacial Research (NIDCR) </a></li><li><a href="https://www.niddk.nih.gov/">National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)</a> </li><li><a href="https://www.ninds.nih.gov/">National Institute of Neurological Disorders and Stroke (NINDS)</a> </li><li><a href="https://nia.nih.gov/">National Institute on Aging (NIA) </a></li><li><a href="https://www.niaaa.nih.gov/">National Institute on Alcohol Abuse and Alcoholism (NIAAA) </a></li><li><a href="https://www.nida.nih.gov/">National Institute on Drug Abuse (NIDA)</a> </li><li><a href="https://commonfund.nih.gov/">NIH Common Fund</a></li></ul> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--gradient-card paragraph--view-mode--default"> <div class='container'> <div class='pattern'> <div class="content-card-grid"> <div class="row"> <div class="col-md-4 order-1"> <div class='card gradient'> <div class='card-body'> <h3 class='card-title'> Contacts </h3> <div class='card-text'> <p><a href="/cdn-cgi/l/email-protection#8dc3c4c3c9dea0c9e8fbe4eee8fecde3e4e5a3eae2fb">Eric Hudak, Ph.D.</a><br>NINDS</p> </div> </div> </div> </div> <div class="col-md-8 order-2"> <h3>Resources</h3> <p><ul><li><a href="https://www.nibib.nih.gov/research-program/medical-devices-to-treat-pain">Developing Medical Devices to Treat Pain webinar</a></li><li><a href="https://www.nibib.nih.gov/node/81436">Developing Medical Devices to Treat Pain FAQs</a></li></ul></p> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default"> <div class='container'> <div class="dynamic_content"> </div> </div> </div> <div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default"> <div class='container'> <div class="dynamic_content"> </div> </div> </div> <div class="paragraph paragraph--type--basic-content paragraph--view-mode--default"> <div class="container"> <div class='basic-content content-align-left pattern'> <div class='basic-content-grid-container ' style=''> <h2 class='basic-content-grid-h2-no-media'> View Other Research Programs in This Focus Area </h2> <div class="basic-content-grid-no-media"> <div> <ul><li><a href="https://heal.nih.gov/research/preclinical-translational/optimization-non-addictive-therapies">Development and Optimization of Non-Addictive Therapies to Treat Pain</a></li><li><a href="https://heal.nih.gov/research/preclinical-translational/novel-targets">Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain</a> </li><li><a href="https://heal.nih.gov/research/preclinical-translational/screening-platform">Preclinical Screening Platform for Pain (PSPP)</a></li><li><a href="https://heal.nih.gov/research/preclinical-translational/restoring-joint-health-function-reduce-pain">Restoring Joint Health and Function to Reduce Pain Consortium (Re-JOIN)</a></li><li><a href="https://heal.nih.gov/research/preclinical-translational/novel-drugs-screening-platforms">Translational Research to Advance Testing of Novel Drugs and Human Cell-based Screening Platforms to Treat Pain and Opioid Use Disorder</a></li><li><a href="https://heal.nih.gov/research/preclinical-translational/integrated-research" hreflang="en">Integrated Basic and Clinical Team-Based Research in Pain</a></li></ul> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </main> <div class="container"> <p class="last-updated">Page last updated August 20, 2024</p> </div> </div> </div> <footer class="fluid-container p-3 footer" role="contentinfo"> <div class="container"> <div class="row"> <div class="col-12 col-md-3"> <div class="footer-logo"><a href="/"><img alt="NIH HEAL Initiative" 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Translating Discoveries into Effective Devices to Treat Pain | NIH HEAL Initiative