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width="1.25rem" xmlns="http://www.w3.org/2000/svg"><polyline points="6 9 6 2 18 2 18 9"></polyline><path d="M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2"></path><rect x="6" y="14" width="12" height="8"></rect></svg></a></button></div></div><div><div class="flex flex-wrap"><p class=" text-primary font-semibold">News</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1"></div><p class=" text-primary font-semibold">Article</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1 "></div><time class="text-gray-500 " dateTime="2024-09-03T16:11:07.825">September 3, 2024</time></div><h1 class="text-[26px] font-medium leading-8">The Connection Between Cancer Treatment Choices and Suicide Mortality</h1><div class="py-3 text-gray-600 md:flex flex-col md:justify-between"><div class="flex flex-col xs:flex-row"><p class="mr-1 self-start">Author(s):</p><div class="flex flex-col xs:flex-row mb-3 md:mb-0"><div class="flex flex-wrap"><span class="text-md mr-2"><a class="text-author text-gray-500 hover:text-primary underline hover:no-underline decoration-gray-400" href="/authors/pearl-steinzor">Pearl Steinzor</a></span></div></div></div><div class="max-w-full"><div class="flex flex-wrap sm:flex-nowrap items-center w-fit my-2"></div><div class="w-full flex flex-col sm:flex-row justify-between mt-2"><div class="block md:hidden "><div class="mt-2 flex items-center max-w-fit"><button title="The Connection Between Cancer Treatment Choices and Suicide Mortality" aria-label="facebook" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#3b5998"></circle><path d="M34.1,47V33.3h4.6l0.7-5.3h-5.3v-3.4c0-1.5,0.4-2.6,2.6-2.6l2.8,0v-4.8c-0.5-0.1-2.2-0.2-4.1-0.2 c-4.1,0-6.9,2.5-6.9,7V28H24v5.3h4.6V47H34.1z" fill="white"></path></svg></button><button aria-label="twitter" 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viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#7f7f7f"></circle><path d="M17,22v20h30V22H17z M41.1,25L32,32.1L22.9,25H41.1z M20,39V26.6l12,9.3l12-9.3V39H20z" fill="white"></path></svg></button><a class="print-wrap flex justify-center items-center cursor-pointer"><svg id="print" xmlns="http://www.w3.org/2000/svg" width="24" height="24" fill="currentColor" class="print bi bi-printer" viewBox="0 0 16 16"> <path d="M2.5 8a.5.5 0 1 0 0-1 .5.5 0 0 0 0 1z"></path> <path d="M5 1a2 2 0 0 0-2 2v2H2a2 2 0 0 0-2 2v3a2 2 0 0 0 2 2h1v1a2 2 0 0 0 2 2h6a2 2 0 0 0 2-2v-1h1a2 2 0 0 0 2-2V7a2 2 0 0 0-2-2h-1V3a2 2 0 0 0-2-2H5zM4 3a1 1 0 0 1 1-1h6a1 1 0 0 1 1 1v2H4V3zm1 5a2 2 0 0 0-2 2v1H2a1 1 0 0 1-1-1V7a1 1 0 0 1 1-1h12a1 1 0 0 1 1 1v3a1 1 0 0 1-1 1h-1v-1a2 2 0 0 0-2-2H5zm7 2v3a1 1 0 0 1-1 1H5a1 1 0 0 1-1-1v-3a1 1 0 0 1 1-1h6a1 1 0 0 1 1 1z"></path></svg></a></div><style> .print-wrap { width: 32px; height: 32px; background: #7F7F7F; border-radius: 100%; } .print { background: #7F7F7F; color: white; padding: 2px; border-radius: 100%; } </style></div></div></div></div><div class=" lg:w-full flex flex-col lg:flex-row lg:items-center lg:justify-end"></div><p class="py-2 mb-2 text-sm italic text-gray-600">Patients with cancer who forego surgery have higher suicide incidence than those who undergo treatment, a study finds.</p><div class="py-2"><div class="blockText_blockContent__TbCXh"><p class="pb-2">Patients with <a target="_blank" href="https://www.ajmc.com/compendium/oncology">cancer</a> who did not undergo surgery faced a significantly higher risk of suicide, particularly among those for whom surgery was recommended, according to a recent study.<sup class="text-inherit">1</sup> In contrast, undergoing radiotherapy or chemotherapy did not show similar increases in suicide mortality. </p><div class=""><div style="width:35%;float:left;max-width:525px;margin:0 1.5rem 1.5rem 0;clear:both;cursor:" class=" figure"><div class="flex-none relative text-center"><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;max-width:100%"><img style="display:block;max-width:100%;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0" alt="" aria-hidden="true" src="data:image/svg+xml,%3csvg%20xmlns=%27http://www.w3.org/2000/svg%27%20version=%271.1%27%20width=%275416%27%20height=%273611%27/%3e"/></span><img alt="Doctor and patient with breast cancer. | Image Credit: Pixel-Shot - stock.adobe.com .jpeg" title="Doctor and patient with breast cancer. | Image Credit: Pixel-Shot - stock.adobe.com .jpeg" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="Doctor and patient with breast cancer. | Image Credit: Pixel-Shot - stock.adobe.com .jpeg" title="Doctor and patient with breast cancer. | Image Credit: Pixel-Shot - stock.adobe.com .jpeg" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F9fb5b784d1fe5baee7f4b6916f89a8e68ffb7a39-5416x3611.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 1x" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F9fb5b784d1fe5baee7f4b6916f89a8e68ffb7a39-5416x3611.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div id="image-caption" class="text-gray-500 italic"><div class="blockText_blockContent__TbCXh"><p class="pb-2"><div style="text-align:center">Researchers aimed to investigate whether specific cancer treatment modalities were associated with suicide deaths. | Image Credit: Pixel-Shot - stock.adobe.com </div></p></div></div><div class="top-[-100%] block w-[1px] transition-opacity duration-500 ease-in-out opacity-0 overflow-hidden"><img class="m-auto absolute inset-0 max-w-[0%] max-h-[0%] border-[3px] border-solid border-white shadow-[0px_0px_8px_rgba(0,0,0,0.3)] box-border transition ease-in-out duration-500" src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9fb5b784d1fe5baee7f4b6916f89a8e68ffb7a39-5416x3611.jpg?fit=crop&auto=format"/></div></div><style> #image-caption p{ font-size: 12px; max-width: 525px; margin: 0 auto; text-align: center; } </style></div><p class="pb-2">The study suggests that surgical treatment may provide patients with a sense of hope, potentially lowering suicide risk.</p><p class="pb-2"></p><p class="pb-2">“The association of undergoing different cancer treatments with suicide risk are not well understood,” wrote the researchers of the study. “We investigated whether specific cancer treatment modalities were associated with suicide deaths.”</p><p class="pb-2"></p><p class="pb-2">The risk of suicide among patients undergoing cancer treatments is significantly elevated compared with the general population.<sup class="text-inherit">2</sup> Therefore, it is important to implement suicide screening among patients undergoing cancer operations, especially those whose demographic and tumor characteristics are associated with the highest suicide risk.</p><p class="pb-2"></p><p class="pb-2">However, the associations of different cancer treatments with suicide risk are not well understood.<sup class="text-inherit">1</sup> Therefore, the researchers aimed to investigate whether specific cancer treatment modalities were associated with suicide deaths.</p><p class="pb-2"></p><p class="pb-2">The study was based on data from the Surveillance, Epidemiology, and End Results (SEER) Program Registries from 2000 to 2020 for patients with a first primary diagnosis of the 15 most common solid organ cancers.</p><p class="pb-2"></p><p class="pb-2">The researchers identified each patient's surgical status, surgical recommendations, radiotherapy, and chemotherapy for first-course treatment. Standardized mortality ratios (SMRs) based on suicide deaths were calculated, while 2-sided <em>P </em>values less than .05 indicated statistical significance. All data analyses were performed from September 2023 to July 2024.</p><p class="pb-2"></p><p class="pb-2">A total of 5,164,987 patients were identified with a first primary cancer diagnosis, including 48.8% female and 51.2% male patients. The median (IQR) age at diagnosis was 62 (52-72) years. Of these patients, 7132 (0.1%) died by suicide. The mean person-years at risk was 5.87 years.</p><p class="pb-2"></p><p class="pb-2">Patients who did not undergo surgery experienced the highest suicide deaths, particularly among those with pancreatic, esophageal, lung or bronchial, and stomach cancers. SMRs showed a significant increase in suicide rates for these patients compared with those who underwent surgery. For instance, patients with pancreatic cancer had a 331% higher suicide rate than the general population, with variations depending on treatment: 77% higher with surgery, 598% higher without surgery, and 1011% higher without surgery despite a recommendation for it.</p><p class="pb-2"></p><p class="pb-2">The highest rates of suicide deaths were observed among patients who were recommended surgery but did not proceed with it, across all cancer stages. This pattern was consistent regardless of cancer stage, race, ethnicity, age, or sex. In contrast, patients who underwent radiotherapy or chemotherapy did not show a significant association with increased suicide deaths.</p><p class="pb-2"></p><p class="pb-2">The researchers believe that higher suicide deaths among patients who did not undergo recommended surgery may be explained by 3 potential reasons: patients who refuse surgery may be an early sign of higher suicide risk; patient-elected death may suggest their loss of autonomy, dignity, or functional status; and varying access to cancer surgery may increase disparities in access to recommended surgery.</p><p class="pb-2"></p><p class="pb-2">The researchers acknowledged some limitations to the study, including lack of information on psychiatric conditions and the inability to know a patient’s reason to pursue or decline therapy.</p><p class="pb-2"></p><p class="pb-2">Despite these limitations, the researchers believe the study suggests that surgical treatment may provide patients with a sense of hope, potentially lowering suicide risk.</p><p class="pb-2"></p><p class="pb-2">“These findings warrant further investigation into reasons for higher suicide deaths among patients who did not undergo surgery, including the role played by comorbid psychiatric conditions, lack of hope for the future, quality-of-life changes, and surgical access barriers,” wrote the researchers.</p><p class="pb-2"></p><p class="pb-2"><strong>References</strong></p><p class="pb-2">1. Chen ML, Gomez SL, O’Hara R, et al. Surgery and suicide deaths among patients with cancer. <em>JAMA Netw Open.</em> 2024;7(9):e2431414. doi:10.1001/jamanetworkopen.2024.31414</p><p class="pb-2">2. Potter AL, Haridas C, Neumann K, et al. Incidence, timing, and factors associated with suicide among patients undergoing surgery for cancer in the US. <em>JAMA Oncol</em>. 2023;9(3):308-315. doi:<a rel="nofollow noreferrer noopener" target="_blank" href="http://jamanetwork.com/article.aspx?doi=10.1001/jamaoncol.2022.6549">10.1001/jamaoncol.2022.6549</a></p><p class="pb-2"></p></div></div><div class="flex items-center lg:w-3/4 mb-4 pb-12"></div><div class="jsx-19ede9f0a5a45918 py-4 relative bg-primary md:px-8 -ml-6 xs:ml-0 w-screen xs:w-auto"><div class="jsx-19ede9f0a5a45918 px-4 sm:px-0"><div class="flex justify-between items-center py-1 space-x-4 border-0 select-none sm:border-b border-secondary"><div class="text-3xl text-white text-lg sm:text-3xl">Related Videos</div></div></div><div style="scroll-snap-type:none" class="jsx-19ede9f0a5a45918 flex items-start overflow-x-auto space-x-4 py-4 relative mx-auto w-full pl-4"><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" 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src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4b49b8eefe53296c5969788aa0136aad30f4af41-2880x1620.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div class="w-full flex-wrap text-center text-sm mt-4 font-light no-underline text-white"></div></a></div></div><div class="relative block sm:hidden"><div class="mt-4 overflow-hidden"><div class="flex justify-between"><div class="flex items-center clear-both pt-4 pb-2 text-3xl lg:text-2xl xl:text-3xl min-w-fit ">Related Content </div><div class="hidden lg:flex w-full flex-col justify-end items-end"><div class="hidden w-full lg:flex flex-wrap pb-2 gap-x-2 gap-y-1 justify-end items-end"></div></div></div><div class="w-full mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-zanidatamab-hrii-for-her2-biliary-tract-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/2f366a4ab7421a6a697b539c22b8aedf46713899-6000x4000.jpg?fit=crop&auto=format" alt="FDA approval. | Image Credit: syahrir - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 21st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-zanidatamab-hrii-for-her2-biliary-tract-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent">FDA Approves Zanidatamab-hrii for HER2+ Biliary Tract Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-zanidatamab-hrii-for-her2-biliary-tract-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Currently, chemotherapy remains a common treatment for biliary tract cancers, which have a limited survival rate. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/exploring-racial-ethnic-disparities-in-cancer-care-prior-authorization-decisions?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="managed care cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/exploring-racial-ethnic-disparities-in-cancer-care-prior-authorization-decisions?utm_source=www.ajmc.com&utm_medium=relatedContent">Exploring Racial, Ethnic Disparities in Cancer Care Prior Authorization Decisions</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/exploring-racial-ethnic-disparities-in-cancer-care-prior-authorization-decisions?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we're talking with the author of a study published in the October 2024 issue of The American Journal of Managed Care® that explored prior authorization decisions in cancer care by race and ethnicity for commercially insured patients.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/psoriasis-risk-linked-to-elevated-non-hdl-to-hdl-cholesterol-ratio-study-finds?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/8b7cfa2a3f3dbbd749e3d7e2823b76e3c8c7ecbf-4563x3287.jpg?fit=crop&auto=format" alt="Cleansing vessels and veins from cholesterol. | Image credit: Kudryavtsev - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 19th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/psoriasis-risk-linked-to-elevated-non-hdl-to-hdl-cholesterol-ratio-study-finds?utm_source=www.ajmc.com&utm_medium=relatedContent">Psoriasis Risk Linked to Elevated Non-HDL to HDL Cholesterol Ratio, Study Finds</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/psoriasis-risk-linked-to-elevated-non-hdl-to-hdl-cholesterol-ratio-study-finds?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Data reveal a strong association between non–high-density lipoprotein (non-HDL) cholesterol to HDL cholesterol ratio and psoriasis onset in US adults. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/examining-low-value-cancer-care-trends-amidst-the-covid-19-pandemic?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/453ff95d3edc29442e2af71658751e2f26adc78e-2500x2500.jpg?fit=crop&auto=format" alt="Managed Care Cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 25th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/examining-low-value-cancer-care-trends-amidst-the-covid-19-pandemic?utm_source=www.ajmc.com&utm_medium=relatedContent">Examining Low-Value Cancer Care Trends Amidst the COVID-19 Pandemic</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/examining-low-value-cancer-care-trends-amidst-the-covid-19-pandemic?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we're talking with the authors of a study published in the April 2024 issue of The American Journal of Managed Care® about their findings on the rates of low-value cancer care services throughout the COVID-19 pandemic. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/uniting-to-support-patients-with-cancer-beyond-treatment?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/7b19fa1e939847d53496336b563fea0181d9d5dc-1200x675.jpg?fit=crop&auto=format" alt="Kasey Bond, MPH, Perlmutter Cancer Center" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 17th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/uniting-to-support-patients-with-cancer-beyond-treatment?utm_source=www.ajmc.com&utm_medium=relatedContent">Uniting to Support Patients With Cancer Beyond Treatment</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/uniting-to-support-patients-with-cancer-beyond-treatment?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Kasey Bond, MPH, of Perlmutter Cancer Center at NYU Langone Health, speaks to why it’s vital to keep patients at the center of all strategic partnerships between academic institutions and community-based oncology practices.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/rsv-vaccine-proven-effective-in-reducing-rsv-related-hospitalizations?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/d1024943b40e0b87ca36ca1c2a1de913f336757d-7360x4912.jpg?fit=crop&auto=format" alt="Blood sample tube for RSV test. | Image credit: JUN LI - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 15th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/rsv-vaccine-proven-effective-in-reducing-rsv-related-hospitalizations?utm_source=www.ajmc.com&utm_medium=relatedContent"> RSV Vaccine Proven Effective in Reducing RSV-Related Hospitalizations</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kennedy-ferruggia">Kennedy Ferruggia</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/rsv-vaccine-proven-effective-in-reducing-rsv-related-hospitalizations?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Respiratory syncytial virus (RSV) vaccination is approximately 77% to 81% effective against hospital and emergency department encounters among older adults, study finds. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="relative hidden sm:block"><div class="mt-4 overflow-hidden"><div class="flex justify-between"><div class="flex items-center clear-both pt-4 pb-2 text-3xl lg:text-2xl xl:text-3xl min-w-fit ">Related Content </div><div class="hidden lg:flex w-full flex-col justify-end items-end"><div class="hidden w-full lg:flex flex-wrap pb-2 gap-x-2 gap-y-1 justify-end items-end"></div></div></div><div class="w-full mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-zanidatamab-hrii-for-her2-biliary-tract-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/2f366a4ab7421a6a697b539c22b8aedf46713899-6000x4000.jpg?fit=crop&auto=format" alt="FDA approval. | Image Credit: syahrir - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 21st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-zanidatamab-hrii-for-her2-biliary-tract-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent">FDA Approves Zanidatamab-hrii for HER2+ Biliary Tract Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-zanidatamab-hrii-for-her2-biliary-tract-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Currently, chemotherapy remains a common treatment for biliary tract cancers, which have a limited survival rate. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/exploring-racial-ethnic-disparities-in-cancer-care-prior-authorization-decisions?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="managed care cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/exploring-racial-ethnic-disparities-in-cancer-care-prior-authorization-decisions?utm_source=www.ajmc.com&utm_medium=relatedContent">Exploring Racial, Ethnic Disparities in Cancer Care Prior Authorization Decisions</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/exploring-racial-ethnic-disparities-in-cancer-care-prior-authorization-decisions?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we're talking with the author of a study published in the October 2024 issue of The American Journal of Managed Care® that explored prior authorization decisions in cancer care by race and ethnicity for commercially insured patients.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/psoriasis-risk-linked-to-elevated-non-hdl-to-hdl-cholesterol-ratio-study-finds?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/8b7cfa2a3f3dbbd749e3d7e2823b76e3c8c7ecbf-4563x3287.jpg?fit=crop&auto=format" alt="Cleansing vessels and veins from cholesterol. | Image credit: Kudryavtsev - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 19th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/psoriasis-risk-linked-to-elevated-non-hdl-to-hdl-cholesterol-ratio-study-finds?utm_source=www.ajmc.com&utm_medium=relatedContent">Psoriasis Risk Linked to Elevated Non-HDL to HDL Cholesterol Ratio, Study Finds</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/psoriasis-risk-linked-to-elevated-non-hdl-to-hdl-cholesterol-ratio-study-finds?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Data reveal a strong association between non–high-density lipoprotein (non-HDL) cholesterol to HDL cholesterol ratio and psoriasis onset in US adults. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/examining-low-value-cancer-care-trends-amidst-the-covid-19-pandemic?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/453ff95d3edc29442e2af71658751e2f26adc78e-2500x2500.jpg?fit=crop&auto=format" alt="Managed Care Cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 25th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/examining-low-value-cancer-care-trends-amidst-the-covid-19-pandemic?utm_source=www.ajmc.com&utm_medium=relatedContent">Examining Low-Value Cancer Care Trends Amidst the COVID-19 Pandemic</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/examining-low-value-cancer-care-trends-amidst-the-covid-19-pandemic?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we're talking with the authors of a study published in the April 2024 issue of The American Journal of Managed Care® about their findings on the rates of low-value cancer care services throughout the COVID-19 pandemic. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/uniting-to-support-patients-with-cancer-beyond-treatment?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/7b19fa1e939847d53496336b563fea0181d9d5dc-1200x675.jpg?fit=crop&auto=format" alt="Kasey Bond, MPH, Perlmutter Cancer Center" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 17th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/uniting-to-support-patients-with-cancer-beyond-treatment?utm_source=www.ajmc.com&utm_medium=relatedContent">Uniting to Support Patients With Cancer Beyond Treatment</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/uniting-to-support-patients-with-cancer-beyond-treatment?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Kasey Bond, MPH, of Perlmutter Cancer Center at NYU Langone Health, speaks to why it’s vital to keep patients at the center of all strategic partnerships between academic institutions and community-based oncology practices.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/rsv-vaccine-proven-effective-in-reducing-rsv-related-hospitalizations?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/d1024943b40e0b87ca36ca1c2a1de913f336757d-7360x4912.jpg?fit=crop&auto=format" alt="Blood sample tube for RSV test. | Image credit: JUN LI - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 15th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/rsv-vaccine-proven-effective-in-reducing-rsv-related-hospitalizations?utm_source=www.ajmc.com&utm_medium=relatedContent"> RSV Vaccine Proven Effective in Reducing RSV-Related Hospitalizations</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kennedy-ferruggia">Kennedy Ferruggia</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/rsv-vaccine-proven-effective-in-reducing-rsv-related-hospitalizations?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Respiratory syncytial virus (RSV) vaccination is approximately 77% to 81% effective against hospital and emergency department encounters among older adults, study finds. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="pb-24"></div></div><script type="application/ld+json">{"@context":"https://schema.org","@type":"NewsArticle","headline":"The Connection Between Cancer Treatment Choices and Suicide Mortality","datePublished":"2024-09-03T16:11:07.825Z","dateModified":"2024-09-03T16:11:15Z","inLanguage":"en-US","image":"https://cdn.sanity.io/images/0vv8moc6/ajmc/9fb5b784d1fe5baee7f4b6916f89a8e68ffb7a39-5416x3611.jpg?fit=crop&auto=format","mainEntityOfPage":{"@type":"WebPage","@id":"https://www.ajmc.com/view/the-connection-between-cancer-treatment-choices-and-suicide-mortality"},"publisher":{"@type":"Organization","name":"AJMC","logo":{"@type":"ImageObject","url":"https://www.ajmc.com/ajmc_logo_inverted.png"}},"keywords":"Cancer Surgery and Suicide Risk,Suicide Rates in Cancer Patients,Impact of Cancer Treatment on Mental Health","articleBody":"Patients with cancer who did not undergo surgery faced a significantly higher risk of suicide, particularly among those for whom surgery was recommended, according to a recent study.1 In contrast, undergoing radiotherapy or chemotherapy did not show similar increases in suicide mortality. \n\n\n\nThe study suggests that surgical treatment may provide patients with a sense of hope, potentially lowering suicide risk.\n\n\n\n“The association of undergoing different cancer treatments with suicide risk are not well understood,” wrote the researchers of the study. “We investigated whether specific cancer treatment modalities were associated with suicide deaths.”\n\n\n\nThe risk of suicide among patients undergoing cancer treatments is significantly elevated compared with the general population.2 Therefore, it is important to implement suicide screening among patients undergoing cancer operations, especially those whose demographic and tumor characteristics are associated with the highest suicide risk.\n\n\n\nHowever, the associations of different cancer treatments with suicide risk are not well understood.1 Therefore, the researchers aimed to investigate whether specific cancer treatment modalities were associated with suicide deaths.\n\n\n\nThe study was based on data from the Surveillance, Epidemiology, and End Results (SEER) Program Registries from 2000 to 2020 for patients with a first primary diagnosis of the 15 most common solid organ cancers.\n\n\n\nThe researchers identified each patient's surgical status, surgical recommendations, radiotherapy, and chemotherapy for first-course treatment. Standardized mortality ratios (SMRs) based on suicide deaths were calculated, while 2-sided P values less than .05 indicated statistical significance. All data analyses were performed from September 2023 to July 2024.\n\n\n\nA total of 5,164,987 patients were identified with a first primary cancer diagnosis, including 48.8% female and 51.2% male patients. The median (IQR) age at diagnosis was 62 (52-72) years. Of these patients, 7132 (0.1%) died by suicide. The mean person-years at risk was 5.87 years.\n\n\n\nPatients who did not undergo surgery experienced the highest suicide deaths, particularly among those with pancreatic, esophageal, lung or bronchial, and stomach cancers. SMRs showed a significant increase in suicide rates for these patients compared with those who underwent surgery. For instance, patients with pancreatic cancer had a 331% higher suicide rate than the general population, with variations depending on treatment: 77% higher with surgery, 598% higher without surgery, and 1011% higher without surgery despite a recommendation for it.\n\n\n\nThe highest rates of suicide deaths were observed among patients who were recommended surgery but did not proceed with it, across all cancer stages. This pattern was consistent regardless of cancer stage, race, ethnicity, age, or sex. In contrast, patients who underwent radiotherapy or chemotherapy did not show a significant association with increased suicide deaths.\n\n\n\nThe researchers believe that higher suicide deaths among patients who did not undergo recommended surgery may be explained by 3 potential reasons: patients who refuse surgery may be an early sign of higher suicide risk; patient-elected death may suggest their loss of autonomy, dignity, or functional status; and varying access to cancer surgery may increase disparities in access to recommended surgery.\n\n\n\nThe researchers acknowledged some limitations to the study, including lack of information on psychiatric conditions and the inability to know a patient’s reason to pursue or decline therapy.\n\n\n\nDespite these limitations, the researchers believe the study suggests that surgical treatment may provide patients with a sense of hope, potentially lowering suicide risk.\n\n\n\n“These findings warrant further investigation into reasons for higher suicide deaths among patients who did not undergo surgery, including the role played by comorbid psychiatric conditions, lack of hope for the future, quality-of-life changes, and surgical access barriers,” wrote the researchers.\n\n\n\nReferences\n\n1. Chen ML, Gomez SL, O’Hara R, et al. Surgery and suicide deaths among patients with cancer. JAMA Netw Open. 2024;7(9):e2431414. doi:10.1001/jamanetworkopen.2024.31414\n\n2. Potter AL, Haridas C, Neumann K, et al. Incidence, timing, and factors associated with suicide among patients undergoing surgery for cancer in the US. JAMA Oncol. 2023;9(3):308-315. doi:10.1001/jamaoncol.2022.6549\n\n","description":"Patients with cancer who forego surgery have higher suicide incidence than those who undergo treatment, a study finds.","author":[{"@type":"Person","name":"Pearl Steinzor"}]}</script></div></div><div class="flex-none w-[300px] z-[9999] relative hidden md:block"><div style="top:5rem" class="sticky custom-spacing"><div class="collapse-container " style="overflow:hidden;max-height:900px;transition:max-height .4s ease-in-out"></div></div></div></div><div id="div-gpt-ad-pixel" style="width:1px;height:1px" class=""></div><noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NK5KQXS" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript><div id="footerOuterWrap" class=" mx-auto flex"><div class="bg-[#00598D] xl:w-[70%] w-[70%] py-12 pl-auto"><div class="xxl:w-[75%] w-[90%] ml-auto"><div><span 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","_key":"2792ac1aa214"}],"_type":"block","style":"normal","_key":"75040848d781"},{"disableTextWrap":false,"_type":"figure","alignment":"left","disableLightBox":true,"_key":"86b45e8dd304","upload_doc":null,"uploadAudio":null,"asset":{"_ref":"image-9fb5b784d1fe5baee7f4b6916f89a8e68ffb7a39-5416x3611-jpg","_type":"reference"},"medias":null,"imgcaption":[{"_type":"block","style":"normal","_key":"8e2b8da51e1f","markDefs":[],"children":[{"_type":"span","marks":["aligncenter"],"text":"Researchers aimed to investigate whether specific cancer treatment modalities were associated with suicide deaths. | Image Credit: Pixel-Shot - stock.adobe.com ","_key":"e1b4e3f78c010"}]}],"widthP":35,"alt":"Doctor and patient with breast cancer. | Image Credit: Pixel-Shot - stock.adobe.com .jpeg"},{"children":[{"text":"The study suggests that surgical treatment may provide patients with a sense of hope, potentially lowering suicide risk.","_key":"7b2867f5c4580","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"7175c675316d","upload_doc":null,"uploadAudio":null,"medias":null,"markDefs":[]},{"_key":"80e2ae237507","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"9316062c90a60"}],"_type":"block","upload_doc":null,"uploadAudio":null,"medias":null,"style":"normal"},{"_key":"70de84ebe290","upload_doc":null,"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"_type":"span","marks":[],"text":"“The association of undergoing different cancer treatments with suicide risk are not well understood,” wrote the researchers of the study. “We investigated whether specific cancer treatment modalities were associated with suicide deaths.”","_key":"d437f81099d30"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"text":"","_key":"e4c00900f5c10","_type":"span","marks":[]}],"upload_doc":null,"uploadAudio":null,"medias":null,"_type":"block","style":"normal","_key":"dd7754d5b88d"},{"uploadAudio":null,"medias":null,"children":[{"_type":"span","marks":[],"text":"The risk of suicide among patients undergoing cancer treatments is significantly elevated compared with the general population.","_key":"c46d630032da0"},{"_type":"span","marks":["superscript"],"text":"2","_key":"a85154cfc2a7"},{"marks":[],"text":" Therefore, it is important to implement suicide screening among patients undergoing cancer operations, especially those whose demographic and tumor characteristics are associated with the highest suicide risk.","_key":"920d23d7c0ba","_type":"span"}],"_type":"block","style":"normal","_key":"0f23eb4201c0","markDefs":[],"upload_doc":null},{"_type":"block","style":"normal","_key":"4f06d37f293b","upload_doc":null,"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"129a932f44440"}]},{"upload_doc":null,"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"_type":"span","marks":[],"text":"However, the associations of different cancer treatments with suicide risk are not well understood.","_key":"67546647a0360"},{"_type":"span","marks":["superscript"],"text":"1","_key":"e0dd723be1c8"},{"marks":[],"text":" Therefore, the researchers aimed to investigate whether specific cancer treatment modalities were associated with suicide deaths.","_key":"f9a5f4d187c7","_type":"span"}],"_type":"block","style":"normal","_key":"ab19b2868c40"},{"medias":null,"_type":"block","style":"normal","_key":"7850c6ee3e97","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"3aa882f4ce320"}],"upload_doc":null,"uploadAudio":null},{"children":[{"marks":[],"text":"The study was based on data from the Surveillance, Epidemiology, and End Results (SEER) Program Registries from 2000 to 2020 for patients with a first primary diagnosis of the 15 most common solid organ cancers.","_key":"0dee9294ac970","_type":"span"}],"_type":"block","style":"normal","upload_doc":null,"uploadAudio":null,"medias":null,"_key":"4ee2596a5e76","markDefs":[]},{"uploadAudio":null,"medias":null,"_type":"block","style":"normal","_key":"81e1c943e640","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"cfd3835eeebf0"}],"upload_doc":null},{"uploadAudio":null,"medias":null,"_type":"block","style":"normal","_key":"6dad1dca3e5a","markDefs":[],"children":[{"_key":"8191842a36a30","_type":"span","marks":[],"text":"The researchers identified each patient's surgical status, surgical recommendations, radiotherapy, and chemotherapy for first-course treatment. Standardized mortality ratios (SMRs) based on suicide deaths were calculated, while 2-sided "},{"_type":"span","marks":["em"],"text":"P ","_key":"8191842a36a31"},{"_type":"span","marks":[],"text":"values less than .05 indicated statistical significance. All data analyses were performed from September 2023 to July 2024.","_key":"8191842a36a32"}],"upload_doc":null},{"_key":"098978f3d26e","markDefs":[],"children":[{"_key":"3dc91e42744a0","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","upload_doc":null,"uploadAudio":null,"medias":null},{"children":[{"_key":"3f015274482a0","_type":"span","marks":[],"text":"A total of 5,164,987 patients were identified with a first primary cancer diagnosis, including 48.8% female and 51.2% male patients. The median (IQR) age at diagnosis was 62 (52-72) years. Of these patients, 7132 (0.1%) died by suicide. The mean person-years at risk was 5.87 years."}],"_type":"block","style":"normal","upload_doc":null,"uploadAudio":null,"medias":null,"_key":"b416e0e6f5b6","markDefs":[]},{"_key":"e500d643a28d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"1f7559978e970"}],"_type":"block","style":"normal","upload_doc":null,"uploadAudio":null,"medias":null},{"medias":null,"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Patients who did not undergo surgery experienced the highest suicide deaths, particularly among those with pancreatic, esophageal, lung or bronchial, and stomach cancers. SMRs showed a significant increase in suicide rates for these patients compared with those who underwent surgery. For instance, patients with pancreatic cancer had a 331% higher suicide rate than the general population, with variations depending on treatment: 77% higher with surgery, 598% higher without surgery, and 1011% higher without surgery despite a recommendation for it.","_key":"82bf4dde378a0"}],"_type":"block","style":"normal","_key":"f283965fabdb","upload_doc":null,"uploadAudio":null},{"style":"normal","_key":"4706a0517415","markDefs":[],"upload_doc":null,"uploadAudio":null,"medias":null,"children":[{"marks":[],"text":"","_key":"730573dff6550","_type":"span"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"The highest rates of suicide deaths were observed among patients who were recommended surgery but did not proceed with it, across all cancer stages. This pattern was consistent regardless of cancer stage, race, ethnicity, age, or sex. In contrast, patients who underwent radiotherapy or chemotherapy did not show a significant association with increased suicide deaths.","_key":"e41aa2e1761d0"}],"_type":"block","style":"normal","_key":"f526256c7378","upload_doc":null,"uploadAudio":null,"medias":null,"markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"","_key":"39355f2411910"}],"_type":"block","style":"normal","_key":"67e2648e0a67","markDefs":[],"upload_doc":null,"uploadAudio":null,"medias":null},{"upload_doc":null,"uploadAudio":null,"medias":null,"children":[{"_type":"span","marks":[],"text":"The researchers believe that higher suicide deaths among patients who did not undergo recommended surgery may be explained by 3 potential reasons: patients who refuse surgery may be an early sign of higher suicide risk; patient-elected death may suggest their loss of autonomy, dignity, or functional status; and varying access to cancer surgery may increase disparities in access to recommended surgery.","_key":"b70d17da785f0"}],"_type":"block","style":"normal","_key":"0d6d05b0b64f","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"","_key":"28b45e63949d0"}],"_type":"block","style":"normal","_key":"5357f887be59","upload_doc":null,"uploadAudio":null,"medias":null,"markDefs":[]},{"style":"normal","_key":"ad3667a8f9e1","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The researchers acknowledged some limitations to the study, including lack of information on psychiatric conditions and the inability to know a patient’s reason to pursue or decline therapy.","_key":"b3ff8c8d00b80"}],"_type":"block","upload_doc":null,"uploadAudio":null,"medias":null},{"upload_doc":null,"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"1d928d19a1bd0"}],"_type":"block","style":"normal","_key":"1c91b567d031"},{"_type":"block","style":"normal","upload_doc":null,"uploadAudio":null,"medias":null,"_key":"57e7dee8a0eb","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Despite these limitations, the researchers believe the study suggests that surgical treatment may provide patients with a sense of hope, potentially lowering suicide risk.","_key":"1043c91ebffe0"}]},{"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"1f9eb29e80490"}],"_type":"block","style":"normal","_key":"ffb214aa0f5a","upload_doc":null},{"children":[{"_type":"span","marks":[],"text":"“These findings warrant further investigation into reasons for higher suicide deaths among patients who did not undergo surgery, including the role played by comorbid psychiatric conditions, lack of hope for the future, quality-of-life changes, and surgical access barriers,” wrote the researchers.","_key":"47af25ee10eb0"}],"upload_doc":null,"uploadAudio":null,"medias":null,"_type":"block","style":"normal","_key":"efc340a865bb","markDefs":[]},{"style":"normal","upload_doc":null,"uploadAudio":null,"medias":null,"_key":"2ef9723e02d9","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"fb99fee160b40"}],"_type":"block"},{"style":"normal","_key":"d955f1c3d576","upload_doc":null,"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"References","_key":"209d71e0b4910"}],"_type":"block"},{"_type":"block","upload_doc":null,"uploadAudio":null,"medias":null,"style":"normal","_key":"ca475adb8ddf","markDefs":[],"children":[{"_type":"span","marks":[],"text":"1. 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This association between elevated NHHR and increased psoriasis risk was consistently observed across various subgroups, further supporting the robustness of the findings.","_key":"e06fdef117140"}],"_type":"block"},{"style":"normal","_key":"49cf15c116c4","markDefs":[],"children":[{"_type":"span","marks":[],"text":"However, the researchers noted some limitations. First, the diagnosis of psoriasis was based on self-reported data from medical professionals or health care practitioners, and this reliance on self-reporting could introduce reporting bias and lacks clinical validation. Second, the relatively small sample size of patients with psoriasis in this study may have affected the reliability of the results. Third, given the cross-sectional nature of the study, it was impossible to establish a definitive cause-and-effect relationship between psoriasis and NHHR. Last, although potential confounders were adjusted for, other unmeasured factors, such as daily medication usage and lifestyle choices, could have influenced the study's findings.","_key":"1fa736ca47a90"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"9e68ca795edc0"}],"_type":"block","style":"normal","_key":"c70cdf538ab0"},{"_key":"51a8ec2b390a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Despite these limitations, the researchers believe the study suggests a connection between an elevated NHHR and a higher chance of developing psoriasis.","_key":"a4818ff3a2d70"}],"_type":"block","style":"normal"},{"_key":"98011d21a431","markDefs":[],"children":[{"marks":[],"text":"","_key":"b97224ad66d70","_type":"span"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"c0c306c9ef85","markDefs":[],"children":[{"_type":"span","marks":[],"text":"“Strong clinical significance exists for the study’s findings, especially when it comes to patient care and illness prevention,” wrote the researchers. “The study’s identification of the relationship between NHHR and psoriasis offers clinicians a potential biomarker for identifying at-risk patients in the clinic and putting targeted preventative measures in place.”","_key":"57a3871ec33c0"}]},{"children":[{"_type":"span","marks":[],"text":"","_key":"764d1a9214510"}],"_type":"block","style":"normal","_key":"92e93a04e31d","markDefs":[]},{"_key":"782a05370409","markDefs":[],"children":[{"marks":[],"text":"","_key":"25677b4e5c1b0","_type":"span"}],"_type":"block","style":"normal"},{"_key":"9ceaf64d089e","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"References","_key":"31f00f7170e80"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"1. Jiang Y, Jia M. Association between non-HDL to HDL cholesterol ratio (NHHR) and psoriasis in adults: a cross-sectional study using 2009-2014 data. ","_key":"586a6c9495230"},{"_type":"span","marks":["em"],"text":"Clin Cosmet Investig Dermatol","_key":"586a6c9495231"},{"_type":"span","marks":[],"text":". 2024;17:2523-2531. doi:10.2147/CCID.S492053","_key":"586a6c9495232"}],"_type":"block","style":"normal","_key":"7d797c7c7994"},{"children":[{"_type":"span","marks":[],"text":"2. Huang X, Li J, Zhang L, Zhang C, Li C. The association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and non-alcoholic fatty liver disease in US adults: a cross-sectional study. ","_key":"e33828e0e6d90"},{"_type":"span","marks":["em"],"text":"Sci Rep","_key":"6b38b8adeb5d"},{"_type":"span","marks":[],"text":". 2024;14(1):24847. doi:10.1038/s41598-024-76002-y","_key":"2df6d923a614"}],"_type":"block","style":"normal","_key":"6736d85f0b82","markDefs":[]},{"_key":"74e11263a221","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"538525230e750"}],"_type":"block","style":"normal"}],"_updatedAt":"2024-11-19T18:46:59Z","published":"2024-11-19T18:46:54.867Z","title":"Psoriasis Risk Linked to Elevated Non-HDL to HDL Cholesterol Ratio, Study Finds","_createdAt":"2024-11-19T18:14:57Z","gptSummary":"A cross-sectional study found a significant positive correlation between elevated non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and increased psoriasis risk in US adults. This association remained consistent across various subgroups, suggesting NHHR's potential as a biomarker for early psoriasis risk assessment. The study utilized data from the National Health and Nutrition Examination Survey (NHANES) and adjusted for multiple covariates. Despite limitations such as reliance on self-reported data and the study's cross-sectional nature, the findings highlight NHHR's clinical significance in identifying at-risk patients.","ExcludeFromPubMedXML":false,"is_visible":true,"_rev":"N06nnxz6bPVwWf6YI4MHtF","authorMapping":[{"lastName":"Steinzor","_rev":"r4x1XD7WYsdf9YL1ZVgDGC","_type":"author","_id":"8f51e09f-2c76-4ef0-83e7-d577a5dfcdd1","_updatedAt":"2024-10-25T15:48:33Z","url":{"_type":"slug","current":"pearl-steinzor"},"firstName":"Pearl ","_createdAt":"2022-10-05T15:22:49Z","profileImage":{"_type":"mainImage","alt":"Pearl Steinzor","asset":{"_ref":"image-aaad3972f041cf080c4994a923d62017c74f0ac3-512x512-jpg","_type":"reference"}},"displayName":"Pearl Steinzor"}],"summary":"Data reveal a strong association between non–high-density lipoprotein (non-HDL) cholesterol to HDL cholesterol ratio and psoriasis onset in US adults. ","_type":"article","audioUrl":"https://s3.us-east-1.amazonaws.com/ai-generated-audios/www.ajmc.com/eb4d7964-7163-40a7-90a4-3f6a56e21fd5_1732040102362.addae219-8452-4c45-9ac2-8379576c2ec8.mp3","articleType":"News","_id":"eb4d7964-7163-40a7-90a4-3f6a56e21fd5","url":"psoriasis-risk-linked-to-elevated-non-hdl-to-hdl-cholesterol-ratio-study-finds","gptTakeaways":"• Elevated NHHR is linked to a 7% increased risk of psoriasis per unit increase, with a 39% higher risk in the highest NHHR tertile.\n\n• The study's findings were consistent across subgroups, reinforcing NHHR's potential as a biomarker for early psoriasis risk assessment.\n\n• Limitations include reliance on self-reported data, small psoriasis sample size, and inability to establish causality due to the study's cross-sectional design.\n\n• Despite limitations, NHHR offers clinicians a potential tool for identifying at-risk patients and implementing targeted preventative 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the NYU Langone Health network, which includes Manhattan, Brooklyn, Queens, and Long Island.","_key":"b8bc0b26f7ec0"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"","_key":"022b5dc8e9330"}],"_type":"block","style":"normal","_key":"059d1b58884b","markDefs":[]},{"markDefs":[],"children":[{"_key":"39f553439e6a0","_type":"span","marks":["em"],"text":"This transcript has been lightly 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cancer?","_key":"eb9b7289b1650"}],"_type":"block","style":"normal","_key":"67cd821c8205"},{"_type":"block","style":"normal","_key":"050118f28e4f","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"dc15524e53d90"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"What I liked so much about it is that all 3 of the presentations touched on a different aspect of those partnerships.","_key":"175aa297b5380"}],"_type":"block","style":"normal","_key":"b46924db2b66"},{"_type":"block","style":"normal","_key":"9e52906791ff","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"e132018a00fc0"}]},{"style":"normal","_key":"57164a9cf698","markDefs":[],"children":[{"_key":"ed7c1c5475e40","_type":"span","marks":[],"text":"I think Dr Mullangi’s [Samyukta Mullangi, MD, MBA, medical director, Thyme Care] presentation really highlighted the importance of our academic institutions and our community-based practices partnering together on policy reform and really being able to advocate for things that improve the care of our cancer patients, improve the lives of our cancer patients. My takeaway from that was really that there's power in numbers and that all of us have a responsibility to do right by the patient. I think that same theme was carried through the other discussions from Dr Roy [Brita Roy, MD, MPH, MHS, NYU Grossman School of Medicine] and Dr Lacouture [Mario Lacouture, MD, NYU Langone Health]."}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"","_key":"c40b1e4700890"}],"_type":"block","style":"normal","_key":"fa59c3ec95ea","markDefs":[]},{"_type":"block","style":"normal","_key":"f92fcd06e540","markDefs":[],"children":[{"_key":"e197a62d86430","_type":"span","marks":[],"text":"Dr Lacouture, I've had the pleasure of working with quite a bit, and with Dr Roy as well. And they sort of came at it from 2 different angles. Dr Lacouture was talking about the need to use specialists across all of our communities to help treat the symptoms for our cancer patients. I think a lot of people think about cancer treatment only as the patient getting chemo or the patient getting radiation or the patient having surgery. But the importance of his talk was to say that there are lots of other things associated with those treatments that are affecting these patients, and it's really important that we partner with those providers in the community and those that are part of some of our larger systems to provide that support to the patients close to where they live."}]},{"_type":"block","style":"normal","_key":"59d059e1c8b3","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"18e4472a762b0"}]},{"style":"normal","_key":"e4c74bf2b663","markDefs":[],"children":[{"_key":"24e0c41cf1b50","_type":"span","marks":[],"text":"It can already be a lot for them to have to travel into the city or out to Long Island or to South Brooklyn for some kind of treatment, and being able to say, “Oh, I have this rash from my chemotherapy. I need to go see a dermatologist,” and these partnerships are allowing us to provide those services as close as possible to where the patient lives."}],"_type":"block"},{"_type":"block","style":"normal","_key":"c519ea27112e","markDefs":[],"children":[{"marks":[],"text":"","_key":"e1aa629596150","_type":"span"}]},{"children":[{"_type":"span","marks":[],"text":"And then I think Dr Roy was coming at it from the perspective of being able to offer services to patients using community-based organizations [CBOs] and how important it is for our academic systems and our community-based practices to work with these CBOs to provide services that undoubtedly affect the patient's health outcomes, but are not services that our institutions might have the ability to provide—so things like supporting patients that have housing insecurity, or helping to provide food to those who might have food insecurity, or dealing with transportation or childcare issues.","_key":"37fda9f2061b0"}],"_type":"block","style":"normal","_key":"d8ada0f105f1","markDefs":[]},{"_key":"b1bd262eba7b","markDefs":[],"children":[{"marks":[],"text":"","_key":"17da22514e2d0","_type":"span"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_key":"a31a31cf78940","_type":"span","marks":[],"text":"I think the takeaway from all 3 of these discussions is that no one entity in any of these areas is able to do everything for everyone, and we really need to come together and identify what each of our strengths is, and then make sure that we're leaning on each other to support the patient for things that might not be in our wheelhouse."}],"_type":"block","style":"normal","_key":"edebdacde6c6"},{"_key":"d9e05cb7f3f1","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"586b9492b15c0"}],"_type":"block","style":"normal"},{"style":"normal","_key":"e58bee079839","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The patient is at the center of everything regardless of what kind of institution you're working in, whether that's a community-based organization, an academic medical center, or a community-based medical practice. Part of it is what I said earlier about the fact that we need to leverage each other's strengths. It’s our responsibility to treat the whole person and not just the patient's cancer. That is even another reason why we need to all come together and partner.The last thing we want to do is make somebody feel like they are only a diagnosis. And so I think that's another big takeaway.","_key":"ead0d2a4f2540"}],"_type":"block"},{"_key":"94c6ed571b52","markDefs":[],"children":[{"_key":"c2a6e253ef410","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"And then the last one I would say is that it's important, especially in academic medicine, that we are collaborating with trusted members of the community, and that it's important that our patients feel comfortable to speak up and feel like they're being heard and feel like they're being represented. 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The study confirmed the vaccines' efficacy, previously demonstrated in clinical trials, using real-world data. Conducted across eight US states, the research found that RSV vaccines were 80% effective against hospitalizations and 81% effective against critical illness in non-immunocompromised individuals. For immunocompromised individuals, effectiveness was 73% for hospitalizations and 77% for emergency department encounters, highlighting the vaccines' success in the 2023-2024 RSV season.","url":"rsv-vaccine-proven-effective-in-reducing-rsv-related-hospitalizations","_createdAt":"2024-11-15T17:08:18Z","_type":"article","body":[{"markDefs":[{"href":"https://www.pharmacytimes.com/","_key":"ea3fbe79d53f","nofollow":false,"blank":true,"_type":"link"}],"children":[{"_type":"span","marks":[],"text":"This article was originally published on ","_key":"a688fcfd8aad"},{"_type":"span","marks":["em","ea3fbe79d53f"],"text":"Pharmacy Times","_key":"bb67bd4f0e95"},{"marks":[],"text":"®","_key":"8ecbde0a7a1e","_type":"span"},{"marks":["em"],"text":". ","_key":"12d6ea011c21","_type":"span"}],"_type":"block","style":"normal","_key":"657cb2934aec"},{"_key":"0e171b4d07ce","markDefs":[],"children":[{"_type":"span","marks":["em"],"text":"","_key":"5c733f284c71"}],"_type":"block","style":"normal"},{"alignment":"left","asset":{"_type":"reference","_ref":"image-d1024943b40e0b87ca36ca1c2a1de913f336757d-7360x4912-jpg"},"disableTextWrap":false,"imgcaption":[{"_key":"5e012a436301","markDefs":[],"children":[{"_type":"span","marks":["aligncenter"],"text":"The findings suggest that RSV vaccination was proved to be 77% to 81% effective against associated critical illness, hospitalization, and emergency department encounters in the 2023-2024 season. | Image credit: JUN LI - stock.adobe.com","_key":"4989572dc44a0"}],"_type":"block","style":"normal"}],"_type":"figure","widthP":35,"disableLightBox":true,"alt":"Blood sample tube for RSV test. | Image credit: JUN LI - stock.adobe.com","_key":"00226861ae47"},{"children":[{"_type":"span","marks":[],"text":"A new study findings published in ","_key":"7f1c755163620"},{"_type":"span","marks":["em","1331ff2d59d9"],"text":"The Lancet","_key":"619da0a1313e"},{"_type":"span","marks":[],"text":" assessed the effectiveness of respiratory syncytial virus (RSV) vaccines against RSV-associated hospitalizations and emergency department encounters among individuals at least 60 years of age. The study was conducted to confirm RSV vaccine effectiveness found in clinical trials against lower respiratory tract disease using real world data.","_key":"5f21390bbfbd"},{"_type":"span","marks":["superscript"],"text":"1","_key":"f41fbe9996d1"}],"_type":"block","style":"normal","_key":"8b56b3711987","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://pubmed.ncbi.nlm.nih.gov/39426837/","_key":"1331ff2d59d9"}]},{"_type":"block","style":"normal","_key":"855f348fe562","markDefs":[],"children":[{"_type":"span","marks":["superscript"],"text":"","_key":"034898ed767f"}]},{"_type":"block","style":"normal","_key":"2f1d8525370a","markDefs":[],"children":[{"text":"According to the CDC, the US experiences up to 160,000 hospitalizations and around 10,000 deaths among older adults due to RSV infection each year. Symptoms typically present like a mild cold but could become more severe among older adults.","_key":"0e2bd22cb7150","_type":"span","marks":[]},{"_type":"span","marks":["superscript"],"text":"2","_key":"d7f311e73d5c"}]},{"_key":"d8102d0d58c3","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"14840b82fafc"}],"_type":"block","style":"normal"},{"style":"normal","_key":"cf0352f85f51","markDefs":[],"children":[{"_type":"span","marks":[],"text":"In June of 2023, the CDC recommended individuals 60 years and older to receive an RSV vaccine after proving to be effective against RSV-associated lower respiratory tract disease in clinical trials.","_key":"030d1248973f0"},{"marks":["superscript"],"text":"1,2 ","_key":"1306743e347d","_type":"span"},{"_type":"span","marks":[],"text":"The trials displayed that RSVPreF3 (Arexvy; GSK) provided 87.5% efficacy against RSV-associated lower respiratory tract disease and RSVpreF (Abrysvo; Pfizer) provided 84.6% efficacy.","_key":"1b5cdcd8919e"},{"_type":"span","marks":["superscript"],"text":"3","_key":"e426f1472f0c"}],"_type":"block"},{"style":"normal","_key":"f6836809cd3e","markDefs":[],"children":[{"_type":"span","marks":["superscript"],"text":"","_key":"7106e62e6e46"}],"_type":"block"},{"style":"normal","_key":"09a1d37d5b8c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"However, researchers found that there was limited real-world data on the vaccine’s effectiveness. To address the gaps in research from the clinical trials, investigators assessed hospitalizations and emergency department encounters among individuals that reported RSV illness for patients that were at least 60 years of age.","_key":"ae8d647d1e650"},{"_type":"span","marks":["superscript"],"text":"1,2","_key":"24068db3d56e"}],"_type":"block"},{"children":[{"_type":"span","marks":["superscript"],"text":"","_key":"4c95c598c63d"}],"_type":"block","style":"normal","_key":"afca1c3157d2","markDefs":[]},{"style":"normal","_key":"b6085ddae71e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The researchers conducted a test-negative design analysis in an electronic health records-based network in 8 US states, which contributed data on inpatient, emergency department, and urgent care encounters among individuals that experienced RSV-associated illness from October 1, 2023, to March 31, 2024. The study authors noted that status of RSV vaccination was confirmed from electronic health record documents, state and city immunization registries, and medical claims.","_key":"b7c77c5b99d60"},{"_key":"3c0c84f5cb32","_type":"span","marks":["superscript"],"text":"1,3"}],"_type":"block"},{"children":[{"marks":["superscript"],"text":"","_key":"b678cc2c35bd","_type":"span"}],"_type":"block","style":"normal","_key":"77a82e50b97b","markDefs":[]},{"markDefs":[],"children":[{"text":"According to the study authors, vaccine effectiveness was measured by an individual’s immunocompromised status, which compared the odds of vaccination among RSV-positive cases and RSV-negative cases. The estimated effectiveness was adjusted for age, race, ethnicity, sex, calendar day, social vulnerability index, amount of non-respiratory medical conditions, presence of underlying respiratory medical conditions, and geographical region.","_key":"eb6cbc8c267a0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"2927d05882fb"},{"style":"normal","_key":"af53d9fda4a5","markDefs":[],"children":[{"marks":[],"text":"","_key":"550345f0be7d","_type":"span"}],"_type":"block"},{"_key":"4ddc52e6eed6","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The results found that, among 28,271 hospitalizations for RSV-like illness in individuals at least 60 years of age and were not immunocompromised, vaccine effectiveness was 80% against RSV-associated hospitalizations and 81% effective against RSV-associated critical illness. Further results found that vaccine effectiveness was 73% among 8435 individuals that were immunocompromised. Additionally, among 36,521 emergency department encounters for RSV-like illness, vaccine effectiveness was 77% in individuals that were immunocompromised, against RSV-associated emergency department encounters.","_key":"b394a1a6aa480"}],"_type":"block","style":"normal"},{"_key":"468d55531325","markDefs":[],"children":[{"text":"","_key":"1a690fbb6c45","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"style":"normal","_key":"a52c5df73e9a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The findings suggest that RSV vaccination was proved to be 77% to 81% effective against associated critical illness, hospitalization, and emergency department encounters in the 2023-2024 season. This marked the first RSV season following the release of the approved vaccines, emphasizing their success.","_key":"808b2f6901b60"}],"_type":"block"},{"_key":"d0f256ef95eb","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"023440be59ec"}],"_type":"block","style":"normal"},{"style":"normal","_key":"1d5c26fa047c","markDefs":[],"children":[{"text":"References","_key":"688c69599085","_type":"span","marks":["strong"]}],"_type":"block"},{"_type":"block","style":"normal","_key":"b5ff7ba14c23","markDefs":[],"children":[{"_type":"span","marks":[],"text":"1. Payne AB, Watts JA, Mitchell PK, et al. Respiratory syncytial virus (RSV) vaccine effectiveness against RSV-associated hospitalisations and emergency department encounters among adults aged 60 years and older in the USA, October, 2023, to March, 2024: a test-negative design analysis. ","_key":"0e186a2f87710"},{"_key":"0e186a2f87711","_type":"span","marks":["em"],"text":"Lancet"},{"_type":"span","marks":[],"text":". 2024;404(10462):1547-1559. doi:10.1016/S0140-6736(24)01738-0","_key":"0e186a2f87712"}]},{"_type":"block","style":"normal","_key":"3699705bce37","markDefs":[],"children":[{"_key":"ffb14ec7f6db0","_type":"span","marks":[],"text":"2. Ferruggia K. RSV Vaccination Could Decrease Hospitalization Among Adults 60 Years and Older. "},{"_type":"span","marks":["em"],"text":"Pharmacy Times","_key":"ffb14ec7f6db1"},{"_key":"ffb14ec7f6db2","_type":"span","marks":[],"text":". News release. September 6, 2024. Accessed November 13, 2024. https://www.pharmacytimes.com/view/rsv-vaccination-could-decrease-hospitalization-among-adults-60-years-and-older"}]},{"_type":"block","style":"normal","_key":"4236bbb54016","markDefs":[],"children":[{"_type":"span","marks":[],"text":"3. Respiratory syncytial virus (RSV) vaccine effectiveness against RSV-associated hospitalisations and emergency department encounters among adults aged 60 years and older in the USA, October, 2023, to March, 2024: a test-negative design analysis. Science Direct. News release. October 19, 2024. Accessed November 13, 2024. https://www.sciencedirect.com/science/article/abs/pii/S0140673624017380","_key":"1ec0495159f90"}]}],"summary":"Respiratory syncytial virus (RSV) vaccination is approximately 77% to 81% effective against hospital and emergency department encounters among older adults, study finds. 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