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DCB - Cancer Systems Biology Consortium - NCI
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If you have questions or need additional information, we invite you to contact NCI's LiveHelp instant messaging service at https://livehelp.cancer.gov, or call the NCI's Contact Center 1-800-4-CANCER (1-800-422-6237) (toll-free from the United States)."> <svg xmlns="http://www.w3.org/2000/svg" height="24" viewBox="0 0 24 24" width="24" class="usa-icon" role="img" aria-hidden="true" focusable="false"> <path d="M0 0h24v24H0z" fill="none"/> <path d="M20 4H4c-1.1 0-1.99.9-1.99 2L2 18c0 1.1.9 2 2 2h16c1.1 0 2-.9 2-2V6c0-1.1-.9-2-2-2zm0 14H4V8l8 5 8-5v10zm-8-7L4 6h16l-8 5z"/> </svg> <span class="usa-sr-only"> Email </span> </a> </section> </div> </div> <div id="page" class="grid-container"> <div class="grid-row grid-gap"> <!-- SECTION NAVIGATION --> <div class="desktop:grid-col-3 nci-no-print"> <nav aria-label="Secondary navigation"> <ul class="usa-sidenav"> <li class="usa-sidenav__item"> <a href="/about-nci/organization/dcb" data-menu-id="988377" class="usa-current usa-current--nci-ancestor">DCB</a> <ul class="usa-sidenav__sublist"> <li class="usa-sidenav__item"> <a href="/about-nci/organization/dcb/research-portfolio" data-menu-id="988383" class="nci-has-children">Research Portfolio</a> </li> <li class="usa-sidenav__item"> <a href="/about-nci/organization/dcb/research-programs" data-menu-id="1042135" class="usa-current usa-current--nci-ancestor">Research Programs</a> <ul class="usa-sidenav__sublist"> <li class="usa-sidenav__item"> <a href="/about-nci/organization/dcb/research-programs/past-programs" data-menu-id="1151696">Past Programs</a> </li> </ul> </li> <li class="usa-sidenav__item"> <a href="/about-nci/organization/dcb/funding" data-menu-id="988385" class="nci-has-children">Funding</a> </li> <li class="usa-sidenav__item"> <a href="/about-nci/organization/dcb/researcher-resources" data-menu-id="1047031">Researcher Resources</a> </li> <li class="usa-sidenav__item"> <a href="/about-nci/organization/dcb/news" data-menu-id="1151616" class="nci-has-children">News & Events</a> </li> <li class="usa-sidenav__item"> <a href="/about-nci/organization/dcb/about" data-menu-id="988387" class="nci-has-children">About DCB</a> </li> <li class="usa-sidenav__item"> <a href="/about-nci/organization/dcb/progress" data-menu-id="1153066" class="nci-has-children">Progress </a> </li> </ul> </li> </ul> </nav> </div> <div class="cgdpl desktop:grid-col-9"> <div id="content" class=""> <main class="contentzone has-section-nav" id="main-content"> <div data-drupal-messages-fallback class="hidden"></div> <!-- ********************************* BEGIN Page Content ********************************** --> <article> <div class="resize-content"> <h1> Cancer Systems Biology Consortium (CSBC) </h1> <div id="cgvBody"> <div data-entity-embed-display="view_mode:media.image_display_article_medium" class="embedded-entity align-right"> <figure class="image-medium centered-set"> <div class="centered-element"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_article/public/cgov_image/media_image/100/100/7/files/csbc-feature-card.jpg?h=982f41e1&itok=FKaiTOw_" width="425" height="319" alt="Cancer Systems Biology Consortium" /> </div> </figure> </div> <div class="blog-intro-text"> <p>Cancer systems biology is uniquely poised to address the complexity associated with cancer through its unique integration of experimental biology and computational and mathematical analysis. Instead of viewing cancer through the lens of a single mutation or alteration, the goal of cancer systems biology is to provide a bird’s eye view of the changing cancer ecosystem, thus allowing cancer biologists and oncologists to understand and predict how one alteration affects an entire tumor system.</p> <p>The multidisciplinary Cancer Systems Biology Consortium (CSBC), which includes cancer biologists, engineers, mathematicians, physicists, and oncologists, aims to tackle the most perplexing issues in cancer to increase our understanding of tumor biology, treatment options, and patient outcome.</p></div> <div class="accordion"> <nav class="on-this-page hide-otp-on-collapse" role="navigation"> <span class="on-this-page__header">On This Page</span> <ul> <li> <a href="#impact-of-cancer-systems-biology-research"> <p>Impact of Cancer Systems Biology Research</p> </a> </li> <li> <a href="#csbc-news"> <p>CSBC News</p> </a> </li> <li> <a href="#csbc-social-media"> <p>CSBC Social Media</p> </a> </li> <li> <a href="#csbc-resources-for-researchers"> <p>CSBC Resources for Researchers</p> </a> </li> <li> <a href="#csbc-associate-membership"> <p>CSBC Associate Membership</p> </a> </li> <li> <a href="#contacts-for-the-csbc"> <p>Contacts for the CSBC</p> </a> </li> <li> <a href="#funded-projects"> <p>Funded Projects</p> </a> </li> <li> <a href="#past-projects"> <p>Past Projects</p> </a> </li> </ul> </nav> <section> <h2 id="impact-of-cancer-systems-biology-research"> <p>Impact of Cancer Systems Biology Research</p> </h2> <p>There has been an explosion in the quantity of available experimental data from high-throughput and single-cell technologies, such as genomic sequencing, transcriptomics, metabolomics, and proteomics. Additionally, targeted experiments on a smaller scale focused on a small number of genes and proteins have provided important information about complex interactions within and between cells. Systems analyses and predictive modeling are necessary to integrate across these datasets that span different length and time scales to convert them into actionable knowledge. </p> <p>DCB has supported development and growth of the cancer systems biology field since <span style="font-weight: 400;">2004. The Cancer Systems Biology Consortium (CSBC), DCB’s most recent effort to support cancer systems biology research, has three main goals:</span></p> <div data-embed-button="cgov_featured_content_button" data-entity-embed-display="view_mode:node.embedded_feature_card_no_image" data-entity-type="node" data-entity-uuid="fab34e9b-d117-4a2a-8589-241195a73dfe" data-langcode="en" data-entity-embed-display-settings="[]" class="embedded-entity align-right"> <div class="feature-card"> <a href="/about-nci/organization/dcb/research-programs/csbc/research-advances"> <h3>Research Advances from the CSBC</h3> <p>Discoveries from the CSBC have led to a better fundamental understanding of cancer biology and are being translated into clinical studies to improve cancer treatment. </p> </a> </div> </div> <ul> <li>Advance our understanding of mechanisms that underlie fundamental processes in cancer</li> <li>Support the broad application of systems biology approaches in cancer research</li> <li>Support the growth of a strong, stable, and diverse research community in cancer systems biology</li> </ul> <p>An external expert panel evaluated the progress towards accomplishment of these goals in 2020. The panel found that CSBC investigators were contributing significant tools and knowledge towards our understanding of the tumor microenvironment, mechanisms of drug resistance and sensitivity, and cancer metastasis. <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="afe35a1c-7a6e-48bb-ba69-3334720bce88" href="/about-nci/organization/dcb/research-programs/csbc/evaluation">A summary of CSBC progress and data describing the impact of the CSBC are publicly available, as is the external expert panel report</a>.</p> <p>It is envisioned that the success of cancer systems biology will encourage investigators to bring a systems biology approach to bear on emerging and difficult cancer questions that will require a systems approach to fully comprehend.</p> </section> <section> <h2 id="csbc-news"> <p>CSBC News</p> </h2> <div data-embed-button="cgov_featured_content_button" data-entity-embed-display="view_mode:node.embedded_feature_card_no_image" data-entity-type="node" data-entity-uuid="c525807b-9c2e-4bbf-8dd3-9c72e93378b5" data-langcode="en" data-entity-embed-display-settings="[]" class="embedded-entity align-right"> <div class="feature-card"> <a href="/about-nci/organization/dcb/research-programs/csbc/investigator-highlights"> <h3>CSBC Investigator Highlights</h3> </a> </div> </div> <p><a href="https://arpa-h.gov/news-and-events/arpa-h-launches-program-transform-cancer-care">ARPA-H recently announced the ADvanced Analysis for Precision cancer Therapy (ADAPT) program</a>, which is “a visionary collaboration between scientists, clinicians, and patients to usher in a new era of cancer care by harnessing advanced technologies to provide a deeper understanding of and treatment response to tumor biology.”</p> <p>ADAPT builds on the impact of cancer systems biology research and complements existing efforts of the CSBC by developing, testing, and validating therapy response biomarkers within a linked clinical trial infrastructure. This new program also incorporates ideas and discussions from the <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="d70909a3-e7f3-4e90-8851-1eec1f24c9cf" href="/about-nci/organization/dcb/news/translationalsysbio">Translational Systems Biology Symposium</a>. </p> <p>Initiatives like ADAPT and the development of new treatment approaches, technologies, and trial design strategies to improve cancer care rely on support for fundamental cancer biology research to increase our understanding of the complexities of cancer. NCI-supported investigator-initiated awards and NCI-led programs, such as CSBC, the <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="a587b994-9a70-44b8-8ce4-f68008a4a512" href="/about-nci/organization/dcb/research-programs/metnet">Metastasis Research Network (MetNet)</a>, and the <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="396869db-2cbc-4d6d-b1a5-232505dc27e9" href="/about-nci/organization/dcb/research-programs/artnet">Acquired Resistance to Therapy Network (ARTNet)</a>, are providing the foundation on which strategies incorporated into ADAPT will benefit patients. </p> </section> <section> <h2 id="csbc-social-media"> <p>CSBC Social Media</p> </h2> <p>CSBC research and funding opportunities are shared on Twitter: <a href="https://twitter.com/NCIsysbio">@NCIsysbio</a></p> </section> <section> <h2 id="csbc-resources-for-researchers"> <p>CSBC Resources for Researchers</p> </h2> <p>The <a href="https://www.cancercomplexity.synapse.org/">Cancer Complexity Knowledge Portal</a> contains the latest available resources generated through the CSBC. Information in the database includes:</p> <ul> <li>Grants</li> <li>Investigators</li> <li>Publications</li> <li>Datasets</li> <li>Tools</li> </ul> </section> <section> <h2 id="csbc-associate-membership"> <p>CSBC Associate Membership</p> </h2> <p>The CSBC offers the opportunity for Associate Membership in the consortium to those who are not currently funded through a CSBC award. Additional information, including eligibility criteria, expectations of associate members, and the application form can be found on the <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="7823e0ce-b58c-495f-9893-93fb59a64948" href="/about-nci/organization/dcb/research-programs/csbc/associate-membership">CSBC Associate Membership webpage</a>. </p> </section> <section> <h2 id="contacts-for-the-csbc"> <p>Contacts for the CSBC</p> </h2> <p>For additional information about the CSBC, please contact <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="d1f7fcf4-c09c-4539-a55b-4d0fcb4852f2" href="/about-nci/organization/dcb/about/contact/hannah-dueck">Dr. Hannah Dueck</a> or <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="246b9cf0-4a20-4abd-89ba-74fb6c3689c2" href="/about-nci/organization/dcb/about/contact/monica-zamisch">Dr. Monica Zamisch</a>. </p> </section> <section> <h2 id="funded-projects"> <p>Funded Projects</p> </h2> <p><strong>Research Centers for Cancer Systems Biology (U54s)</strong></p> <table class="table-default"> <thead> <tr style="height: 13px;"> <th scope="col" style="height: 13px;">Institution</th> <th scope="col" style="height: 13px;">Principal Investigator(s)</th> <th scope="col" style="height: 13px;">Center Title</th> </tr> </thead> <tbody> <tr> <td style="height: 12px;">Columbia University </td> <td style="height: 12px;">Andrea Califano, Barry H. Honig</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/project-details/10931548">Center for Cancer Systems Therapeutics (CaST)</a></td> </tr> <tr> <td style="height: 12px;">Institute for Systems Biology</td> <td style="height: 12px;">James Heath</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/3ueMy-Pax06LT-xTzk6iCQ/project-details/10526101">Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor: Immunotherapy Combinations (ST-Analytics)</a></td> </tr> <tr> <td style="height: 12px;">Massachusetts Institute of Technology</td> <td style="height: 12px;">Forest M. White, Franziska Michor</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/70JOWezrgkmzv7YvtZPw3A/project-details/10729273">Quantitative Systems Biology of Glioblastoma Cells and Their Interactions with the Neuronal and Immunological Milieu</a></td> </tr> <tr> <td style="height: 12px;">Memorial Sloan Kettering Cancer Center</td> <td style="height: 12px;">Christina S. Leslie, Alexander Y. Rudensky</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/cbmS1fiyDEOh3hamr8bCOQ/project-details/10525190">The Center for Tumor-Immune Systems Biology at MSKCC</a></td> </tr> <tr> <td style="height: 12px;">Mayo Clinic Arizona</td> <td style="height: 12px;">Kristin R. Swanson, Peter Canoll</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/84Ku8wGmD0WpPKP2_pcQHg/project-details/10729420">Mathematical Oncology Systems Analysis Imaging Center (MOSAIC)</a></td> </tr> <tr> <td style="height: 12px;">Moffitt Cancer Center</td> <td style="height: 12px;">Alexander R.A. Anderson, Robert A. Gatenby</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/ylMxOcRO1kSMkx6ZdyzATQ/project-details/10730403">The Delta Ecology of NSCLC Treatment</a></td> </tr> <tr> <td style="height: 12px;">Stanford University </td> <td style="height: 12px;">Sylvia K. Plevritis, Edgar G. Engleman</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/E25AM-zOrEeaTcryhi6Rhg/project-details/10729464">Systems Biology of Tumor-Immune-Stromal Interactions in Metastatic Progression</a></td> </tr> <tr> <td style="height: 12px;">University of California, San Francisco</td> <td style="height: 12px;">Nevan Krogan, Trey Ideker</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/lV-7BH6Aw0yv0QldDB7o2w/project-details/10525586">The Cancer Cell Map Initiative v2.0</a></td> </tr> <tr> <td style="height: 12px;">University of Virginia</td> <td style="height: 12px;">Kevin A. Janes, Matthew J. Lazzara</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/MXZSzPaqMUa5BlIUgAc8KQ/project-details/10525280">Systems Analysis of Stress-adapted Cancer Organelles (SASCO) Center</a></td> </tr> </tbody> </table> <p><strong>Research Projects in Cancer Systems Biology (U01s)</strong></p> <table class="table-default"> <thead> <tr style="height: 13px;"> <th scope="col" style="height: 13px;">Institution</th> <th scope="col" style="height: 13px;">Principal Investigator(s)</th> <th scope="col" style="height: 13px;">Center Title</th> </tr> </thead> <tbody> <tr style="height: 12px;"> <td style="height: 12px;">Battelle Pacific Northwest Laboratories</td> <td style="height: 12px;">H. Steven Wiley, Wei-Jun Qian, Herbert M. Sauro</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/g_eOr0cfTkCn-hGEupFbIg/project-details/10148720">Reverse Sensitivity Analysis for Identifying Predictive Proteomics Signatures of Cancer</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">Boston University</td> <td style="height: 12px;">Gerald V. Denis, Andrew Emili, Stefano Monti, Senthil K. Muthuswamy</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/5sHZOyp6fUO7kcXdvWecdA/project-details/10259753">Multiscale Analysis of Metabolic Inflammation as a Driver of Breast Cancer</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">Children’s Hospital of Philadelphia</td> <td style="height: 12px;">Kai Tan, Sarah K. Tasian</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/SEQlkVrXVEifZLDI_s-kCw/project-details/10163819">Towards Rational Design of Combination Therapeutic Targets</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">City of Hope</td> <td style="height: 12px;">Aritro Nath</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/project-details/10909954">Mechanism of Estrogen Independent Proliferation in ER+ Breast Cancer Cells</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">Houston Methodist Research Institute</td> <td style="height: 12px;">Stephen T.C. Wong, Xiang Zhang</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/BmruRF5c-k6GaHUeI33wSQ/project-details/10260556">Spatiotemporal Modeling of Cancer-Niche Interactions in Breast Cancer Bone Metastasis</a></td> </tr> <tr> <td style="height: 12px;">John Hopkins University</td> <td style="height: 12px;">Laura D. Wood, Elana J. Fertig, Rachel Karchin</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/keo_onxpYUyTPUs98zKVGA/project-details/10556018">Interrogation of the Impact of Selection on the Evolution of Human Pancreatic Cancer Precursor Lesions</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">Massachusetts Institute of Technology</td> <td style="height: 12px;">Ernest Fraenkel, Jill P. Mesirov</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/E2Ve1L1XQUWMAmnTRHdRhg/project-details/10219682">Identifying Therapeutic Pathways Targeting Medulloblastoma-Immune Cell Interactions</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">Massachusetts Institute of Technology</td> <td style="height: 12px;">Forest M. White, Nataly Kravchenko-Balasha</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/gufT60oKwUqRBHn470K2Tg/project-details/10190851">Identification of Adaptive Response Mechanisms in Breast Cancer by Information Theory and Proteomics</a></td> </tr> <tr> <td style="height: 12px;">New York University School of Medicine</td> <td style="height: 12px;">Itai Yanai, Richard Mark White</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/w7uSsqg6q0mHykao8Snkkw/project-details/10448890">Identification and Characterization of Cancer Cell States by Novel Computational and Experimental Technologies</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">Oregon Health & Science University</td> <td style="height: 12px;">Gordon B. Mills, Anil Korkut, Han Liang</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/0mFjMi-dDU2dtzhQg9SFQw/project-details/10212771">Mechanistic Maps of Adaptive Responses to Therapeutic Stress to Optimize Combination Therapies</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">St. Jude Children’s Research Hospital</td> <td style="height: 12px;">Jiyang Yu, Jun J. Yang</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/UW-c9RenSEyTx2duc6bhhg/project-details/10304780">Clonal Therapy for Pediatric T-cell Acute Lymphoblastic Leukemia</a></td> </tr> <tr> <td style="height: 12px;">Stanford University</td> <td style="height: 12px;">Andrew J. Gentles</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/-uE8sI6QUEuBqLlmVs3rkg/project-details/10554766">Systems analysis of mechanisms driving response to immunotherapy in clear cell cancers</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">University of Colorado, Denver</td> <td style="height: 12px;">James C. Costello, Scott D. Cramer</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/RunSXdrzHUiUQcWqlD7afA/project-details/10247753">Systems Analysis of Aggressive Prostate Cancer Pathology</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">University of Michigan</td> <td style="height: 12px;">Trachette Jackson</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/5Vnm6syZb0CIGQNzZg3fxQ/project-details/10144947">Multiscale Computational Models Guided By Emerging Cellular Dynamics Quantification for Predicting Optimum Immune Checkpoint and Targeted Therapy Schedules</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">University of North Carolina, Chapel Hill</td> <td style="height: 12px;">Charles M. Perou, Timothy C. Elston</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/oI1EAHa6OEOoW8_ngYiRig/project-details/10140308">Predictive Modeling of the EGFR-MAPK pathway for Triple Negative Breast Cancer Patients</a></td> </tr> <tr> <td style="height: 12px;">University of Southern California</td> <td style="height: 12px;">Stacey D. Finley, Nicholas A. Graham</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/xb8Mbt37xEO5MhSqAhNPhQ/project-details/10557760">Modeling based design of chimeric antigen receptors for Natural Killer cell-based immunotherapy</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">University of Southern California</td> <td style="height: 12px;">Stacey D. Finley, Paul T. Macklin, Shannon M. Mumenthaler</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/K2LOPFDkNEqGzxXdAKo2aA/project-details/10251884">Multiscale Systems Biology Modeling to Exploit Tumor-Stromal Metabolic Crosstalk in Colorectal Cancer</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">University of Texas, Austin</td> <td style="height: 12px;">Amy Brock, Thomas E. Yankeelov</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/DREz-8qi102TBEkdWDfsZQ/project-details/10057183">Systems Approaches to Understanding Subpopulation Heterogeneity in Therapeutic Resistance</a></td> </tr> <tr> <td style="height: 12px;">University of Texas, MD Anderson Cancer Center </td> <td style="height: 12px;">Humam Kadara, Linghua Wang</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/BqViFjiFGU-jOn-ojZSKbA/project-details/10447468">Spatial and Temporal Tumor-Immune Co-Evolution and Interactions that Model Lung Adenocarcinoma Development</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">University of Virginia</td> <td style="height: 12px;">Matthew J. Lazzara</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/baozEdocEki5rzo8UQgC4g/project-details/10218122">Optimal Control Models of Epithelial-Mesenchymal Transition for the Design of Pancreas Cancer Combination Therapy</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">Yale University</td> <td style="height: 12px;">Kathryn Miller-Jensen, Marcus W. Bosenberg</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/G27gEH0zFU20ryK7CCVhpA/project-details/10171565">Systems Analysis of Cell-Cell Communication Networks and Immune Activity in the Melanoma Tumor Microenvironment</a></td> </tr> </tbody> </table> <p><strong>Multi-Consortia Coordinating Center (U24)</strong></p> <table class="table-default"> <thead> <tr style="height: 13px;"> <th scope="col" style="height: 13px;">Institution</th> <th scope="col" style="height: 13px;">Principal Investigator(s)</th> <th scope="col" style="height: 13px;">Center Title</th> </tr> </thead> <tbody> <tr style="height: 12px;"> <td style="height: 12px;">Sage Bionetworks</td> <td style="height: 12px;">Susheel Varma, Jineta Banerjee</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/project-details/10909997">Multi-Consortia Coordinating Center (MC2 Center) for Cancer Biology: Building Interdisciplinary Scientific Communities, Coordinating Impactful Resource Sharing, and Advancing Cancer Research</a></td> </tr> </tbody> </table> </section> <section> <h2 id="past-projects"> <p>Past Projects</p> </h2> <p><strong>Research Centers for Cancer Systems Biology (U54s)</strong></p> <table class="table-default"> <thead> <tr style="height: 13px;"> <th scope="col" style="height: 13px;">Institution</th> <th scope="col" style="height: 13px;">Principal Investigator(s)</th> <th scope="col" style="height: 13px;">Center Title</th> </tr> </thead> <tbody> <tr> <td style="height: 12px;">Arizona State University</td> <td style="height: 12px;">Carlo Maley, Darryl K. Shibata</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/project-details/10392864">Arizona Cancer and Evolution Center (ACE)</a></td> </tr> <tr> <td style="height: 12px;">City of Hope</td> <td style="height: 12px;">Andrea H. Bild</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/G0kVnasyEEuEZ73UEOh58w/project-details/10207524">Combating Subclonal Evolution of Resistant Cancer Phenotypes</a></td> </tr> <tr> <td style="height: 12px;">Columbia University</td> <td style="height: 12px;">Andrea Califano, Barry H. Honig </td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/Ymo-kxI210C2j_rNKm6rGA/project-details/9976471">Centers for Cancer Systems Therapeutics (CaST)</a></td> </tr> <tr> <td style="height: 12px;">Harvard Medical School</td> <td style="height: 12px;">Peter K. Sorger</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/ROxi2hfqckSKt4h0XCvv0g/project-details/10114985">Systems Pharmacology of Therapeutic and Adverse Responses to Immune Checkpoint and Small Molecule Drugs</a></td> </tr> <tr> <td style="height: 12px;">Massachusetts Institute of Technology</td> <td style="height: 12px;">Scott R. Manalis, Douglas A. Lauffenburger</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/aJ5Jmd1Nh0qrUrazHo6fSw/project-details/10162303">Quantitative and Functional Characterization of Therapeutic Resistance in Cancer</a></td> </tr> <tr> <td style="height: 12px;">Memorial Sloan Kettering Cancer Center</td> <td style="height: 12px;">Christina S. Leslie, Alexander Y. Rudensky</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/vaetlXKs006T-Vm5M4b0yQ/project-details/9980798">The CSBC Research Center for Cancer Systems Immunology at MSKCC</a></td> </tr> <tr> <td style="height: 12px;">Oregon Health & Science University</td> <td style="height: 12px;">Laura M. Heiser, Emek Demir, Gordon B. Mills, Rosalie C. Sears, Claire J. Tomlin</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/T2pANEOe90iz7MRjNJ0dmw/project-details/10166783">Measuring, Modeling and Controlling Heterogeneity</a></td> </tr> <tr> <td style="height: 12px;">University of California, Irvine</td> <td style="height: 12px;">John Lowengrub, Arthur D. Lander, Marian L. Waterman</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/project-details/10392892">Complexity, Cooperation and Community in Cancer</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">University of California, San Francisco</td> <td style="height: 12px;">Nevan Krogan, Trey Ideker</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/dI3o7hoqSE-TkDVG3mNkmg/project-details/10142376">Research Center for Cancer Systems Biology: Cancer Cell Map Initiative</a></td> </tr> <tr> <td style="height: 12px;">University of Texas Health Science Center at San Antonio</td> <td style="height: 12px;">Tim H.M. Huang, Victor Jin, Qianben Wang</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/lPY9rKvhZUmpDoBpzbvw8A/project-details/10151542">Systems Analysis of Epigenomic Architecture in Cancer Progression</a></td> </tr> <tr> <td style="height: 12px;">Vanderbilt University</td> <td style="height: 12px;">Vito Quaranta</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/project-details/10375418">Phenotype Heterogeneity and Dynamics in SCLC</a></td> </tr> <tr> <td style="height: 12px;">Yale University</td> <td style="height: 12px;">Andre Levchenko</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/Z0L00CQ570uiagGNsl52SQ/project-details/10003175">Systems Analysis of Phenotypic Switch in Control of Cancer Invasion</a></td> </tr> </tbody> </table> <p><strong>Research Projects in Cancer Systems Biology (U01s)</strong></p> <table class="table-default"> <thead> <tr style="height: 13px;"> <th scope="col" style="height: 13px;">Institution</th> <th scope="col" style="height: 13px;">Principal Investigator(s)</th> <th scope="col" style="height: 13px;">Project Title</th> </tr> </thead> <tbody> <tr> <td style="height: 12px;">City of Hope</td> <td style="height: 12px;">Peter P.H. Lee, Russell C. Rockne, Andrei Rodin</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/project-details/10682540">Experimental-Computational Synthesis of Altered Immune Signaling in Breast Cancer</a></td> </tr> <tr> <td style="height: 12px;">Columbia University</td> <td style="height: 12px;">Raul Rabadan, Teresa Palomero</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/project-details/10675452">Single-Cell Characterization of Tumor and Microenvironment Co-evolution in Peripheral T-cell Lymphomas</a></td> </tr> <tr> <td style="height: 12px;">Dana-Farber Cancer Institute</td> <td style="height: 12px;">Marc Vidal, Martha L. Bulyk, Juan I. Fuxman Bass</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/project-details/10479840">Rewiring of Regulatory Networks in Breast Cancer by Transcription Factor Isoforms</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">Georgia Institute of Technology</td> <td style="height: 12px;">Melissa L. Kemp, Cristina M. Furdui</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/project-details/9769699">Model-based Prediction of Redox-Modulated Responses to Cancer Treatments</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">Massachusetts Institute of Technology</td> <td style="height: 12px;">Douglas A. Lauffenburger, Wilhelm Haas, Kevin Haigis</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/vABnsqKSq0eGzX8QNtfCgQ/project-details/10128402">Systems Approaches to Understanding the Relationships Between Genotype, Signaling, and Therapeutic Efficacy</a></td> </tr> <tr> <td style="height: 12px;">Mayo Clinic Arizona</td> <td style="height: 12px;">Kristin R. Swanson, Leland Hu, Nhan L. Tran</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/35Ru51z7eEid41QCpVSLRQ/project-details/10226953">Quantifying Multiscale Competitive Landscapes of Clonal Diversity in Glioblastoma</a></td> </tr> <tr> <td style="height: 12px;">Moffitt Cancer Center</td> <td style="height: 12px;">Alexander R.A. Anderson, Scott J. Antonia, Robert A. Gatenby</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/ouEnUSRRV0CpKjYhRGYqJg/project-details/10238921">Eco-Evolutionary dynamics of NSCLC to immunotherapy: Response and Resistance</a></td> </tr> <tr> <td style="height: 12px;">University of California, Los Angeles</td> <td style="height: 12px;">Aaron S. Meyer, Eric B. Haura</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/RnTd1Rsdrkq4zMIc_PBjgQ/project-details/10246394">Precision Lung Cancer Therapy Design Through Multiplexed Adapter Measurement</a></td> </tr> <tr> <td style="height: 12px;">University of Pennsylvania</td> <td style="height: 12px;">Arjun Raj, Ravi Radhakrishnan, Ashani T. Weeraratna</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/ljUHXkPWgkmfyyeG72zo8g/project-details/10187526">A Plasticity and Reprogramming Paradigm for Therapy Resistance at the Single Cell Level</a></td> </tr> <tr style="height: 12px;"> <td style="height: 12px;">University of Virginia</td> <td style="height: 12px;">Kevin A. Janes</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/_D6_3QrFKEaBanU0Lb3-Hg/project-details/10208800">An Integrated Systems Approach for Incompletely Penetrant Onco-phenotypes</a></td> </tr> <tr> <td style="height: 12px;">Vanderbilt University</td> <td style="height: 12px;">Vito Quaranta, Carlos F. Lopez</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/k959Ps2yuEqaCnuiPPQDfg/project-details/10176419">Phenotype Transitions in Small Cell Lung Cancer</a></td> </tr> </tbody> </table> <p><strong>Coordinating Center for the CSBC (U24)</strong></p> <table class="table-default"> <thead> <tr style="height: 13px;"> <th scope="col" style="height: 13px;">Institution</th> <th scope="col" style="height: 13px;">Principal Investigator(s)</th> <th scope="col" style="height: 13px;">Center Title</th> </tr> </thead> <tbody> <tr style="height: 12px;"> <td style="height: 12px;">Sage Bionetworks</td> <td style="height: 12px;">Julie Bletz</td> <td style="height: 12px;"><a href="https://reporter.nih.gov/search/U-Pogv2o6U6nCCkVcFNhnQ/project-details/9983640">Coordination Center for Open Collaboration in Systems Biology</a></td> </tr> </tbody> </table> </section> </div> </div> </div> <footer class="article-footer"> <div class="document-dates horizontal"> <ul class="clearfix"> <li> <strong>Updated:</strong> <time datetime="2024-09-16T12:00:00Z">September 16, 2024</time> </li> </ul> </div> <div id="nvcgSlPublicUse"> <div class="slot-item only-SI"> <div class="public-use"> <div id="block-ncids-trans-public-use"> <p><em>If you would like to reproduce some or all of this content, see <a href="/policies/copyright-reuse">Reuse of NCI Information</a> for guidance about copyright and permissions. 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