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A 22 years old, 158 cm of height, 40 kg weight, female, was under Spinal Anesthesia for tibia reconstruction on the right leg. Past medical history was normal. The patient had a right tibia fracture, scheduled for tibia fixation.","author":[{"@context":"https://schema.org","@type":"Person","name":"Innovationinfo Publishing"}],"contributor":[],"dateCreated":"2018-12-03","dateModified":"2018-12-03","datePublished":"2018-01-01","headline":"Local Anesthesia Reversal (LAR) of Total Spinal Anesthesia (TSA) by Lipofun- din (Lipid Emulsion)","inLanguage":"en","keywords":["Spinal Anesthesia","Linoleic Acid","Intralipid","Local anesthesia reversal","Lipofundin"],"locationCreated":null,"publication":"Journal of Health Science and Development","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/37900445/Local_Anesthesia_Reversal_LAR_of_Total_Spinal_Anesthesia_TSA_by_Lipofun_din_Lipid_Emulsion_","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}]}</script><link rel="stylesheet" media="all" 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"https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F37900445%2FLocal_Anesthesia_Reversal_LAR_of_Total_Spinal_Anesthesia_TSA_by_Lipofun_din_Lipid_Emulsion_%3Fauto%3Ddownload"; window.loswp.translateUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F37900445%2FLocal_Anesthesia_Reversal_LAR_of_Total_Spinal_Anesthesia_TSA_by_Lipofun_din_Lipid_Emulsion_%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":57910190,"identifier":"Attachment_57910190","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":37900445,"created_at":"2018-12-03T01:40:49.731-08:00","from_world_paper_id":null,"updated_at":"2021-01-18T10:26:10.050-08:00","_data":{"issue":"1","volume":"1","abstract":"These 3 case reports are the first reports in the medical literature regarding the Local Anesthesia Reversal (LAR) of Total Spinal Anesthesia (TSA) by Lipofundin which is similar to Intralipid having soybean oil fatty acids including Linoleic acid. A 22 years old, 158 cm of height, 40 kg weight, female, was under Spinal Anesthesia for tibia reconstruction on the right leg. Past medical history was normal. The patient had a right tibia fracture, scheduled for tibia fixation.","more_info":"Citation: Joseph Eldor, Pham V, Tran TP, Nguyen XL, Kien NT, et al. (2018) Local Anesthesia Reversal (LAR) of Total Spinal Anesthesia (TSA) by Lipofundin (Lipid Emulsion). Jor Health Sci Development Vol: 1, Issu: 1 (67-72).","journal_name":"Journal of Health Science and Development","page_numbers":"67-72","publication_date":"2018,,","publication_name":"Journal of Health Science and Development"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Local Anesthesia Reversal (LAR) of Total Spinal Anesthesia (TSA) by Lipofun- din (Lipid Emulsion)","broadcastable":true,"draft":false,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [95758512]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":57910190,"attachmentType":"pdf"}"><img alt="First page of “Local Anesthesia Reversal (LAR) of Total Spinal Anesthesia (TSA) by Lipofun- din (Lipid Emulsion)”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/57910190/mini_magick20190110-13823-97skem.png?1547116455" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Local Anesthesia Reversal (LAR) of Total Spinal Anesthesia (TSA) by Lipofun- din (Lipid Emulsion)</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="95758512" href="https://independent.academia.edu/InnovationInfo"><img alt="Profile image of Innovationinfo Publishing" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/95758512/20971427/20815640/s65_innovationinfo.publishing.jpg" />Innovationinfo Publishing</a></div><p class="ds-work-card--detail ds2-5-body-sm">2018, Journal of Health Science and Development</p><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">These 3 case reports are the first reports in the medical literature regarding the Local Anesthesia Reversal (LAR) of Total Spinal Anesthesia (TSA) by Lipofundin which is similar to Intralipid having soybean oil fatty acids including Linoleic acid. A 22 years old, 158 cm of height, 40 kg weight, female, was under Spinal Anesthesia for tibia reconstruction on the right leg. Past medical history was normal. The patient had a right tibia fracture, scheduled for tibia fixation.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":57910190,"attachmentType":"pdf","workUrl":"https://www.academia.edu/37900445/Local_Anesthesia_Reversal_LAR_of_Total_Spinal_Anesthesia_TSA_by_Lipofun_din_Lipid_Emulsion_"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":57910190,"attachmentType":"pdf","workUrl":"https://www.academia.edu/37900445/Local_Anesthesia_Reversal_LAR_of_Total_Spinal_Anesthesia_TSA_by_Lipofun_din_Lipid_Emulsion_"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="57910190" data-landing_url="https://www.academia.edu/37900445/Local_Anesthesia_Reversal_LAR_of_Total_Spinal_Anesthesia_TSA_by_Lipofun_din_Lipid_Emulsion_" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="37900512" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/37900512/Local_Anesthesia_Reversal_LAR_of_Spinal_Anesthesia_by_Lipid_Emulsion_Lipofundin_20_for_Day_Case_Surgery">Local Anesthesia Reversal (LAR) of Spinal Anesthesia by Lipid Emulsion (Lipofundin 20%) for Day Case Surgery</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="95758512" href="https://independent.academia.edu/InnovationInfo">Innovationinfo Publishing</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Health Science and Development, 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">A 46 years old Male was diagnosed with penis fracture due to sexual intercourse. A 72 years old Male was diagnosed as having a tumor on the upper pole of the femur.A 41 years old Female had a Cesarean section. All of them underwent spinal anesthesia for their operations. All of them underwent at the end of their operations Local anesthesia reversal (LAR) of Spinal anesthesia by Lipid Emulsion (Lipofundin 20%) using Bolus and Infusion. The local anesthesia reversal was started in approximately 3 minutes after starting the bolus injection and completed in approximately 30 minutes afterwards.This new modality of LAR can make a great change in the use of spinal anesthesia in day case surgery facilities.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Local Anesthesia Reversal (LAR) of Spinal Anesthesia by Lipid Emulsion (Lipofundin 20%) for Day Case Surgery","attachmentId":57910250,"attachmentType":"pdf","work_url":"https://www.academia.edu/37900512/Local_Anesthesia_Reversal_LAR_of_Spinal_Anesthesia_by_Lipid_Emulsion_Lipofundin_20_for_Day_Case_Surgery","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/37900512/Local_Anesthesia_Reversal_LAR_of_Spinal_Anesthesia_by_Lipid_Emulsion_Lipofundin_20_for_Day_Case_Surgery"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="37900392" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/37900392/Lipid_Emulsion_for_Local_Anesthesia_Reversal_LAR_after_Prolonged_Spinal_Epidural_Anesthesia">Lipid Emulsion for Local Anesthesia Reversal (LAR) after Prolonged Spinal/Epidural Anesthesia</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="95758512" href="https://independent.academia.edu/InnovationInfo">Innovationinfo Publishing</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Health Science and Development, 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">A 71-year-old woman was scheduled for total knee replacement on left side. Combined Spinal Epidural Anesthesia (CSEA) was performed at L3-4 and L2-3 separately and was technically uneventful. Epidural Anesthesia (EA) with levobupivacaine 0.1%+fentanyl (2mcg/ml) was effective at 5 ml/h for postoperative analgesia. Eight hours post-op, she complained of having lost all feeling on the non-operative leg. On examination, she had diminished both touch sensory and motor power on the non-operative leg, but intact on the operative side with VAS at 2/10. Epidural catheter was receded 2 cm and the dose was lowered and paused. Despite of these adjustments after 4 hours, her experience was not improved. It was decided to use lipid emulsion as a challenging therapy. After completion of the lipid therapy, the sensory and movement of the non-operative leg regained normal after 60 min. The severe pain recurred which needed IV morphine titration. The EA of 2-5ml/h was recontinued and effective for pain control for 3 days without no incident. It is the first time in the medical literature that Lipid Emulsion is used for the purpose of LAR (Local Anesthesia Reversal) not connected to LAST (Local Anesthetic Systemic Toxicity). A 71-year-old woman was scheduled for total knee replacement on left side. Past medical history was hypertension, type 2 diabetes, bilateral degenerative knee pain. Combined Spinal Epidural Anesthesia (CSEA) was performed at L3-4 and L2-3 separately and was technically uneventful. Spinal Anesthesia (SA) with 10 mg bupivacaine 0.5% heavy+20mcg fentanyl was effective for surgery. Epidural Anesthesia (EA) with levobupivacaine 0.1%+fentanyl (2mcg/ml) was effective at 5ml/h for postoperative analgesia. She was sent back to ward after free movement of both knees. Eight hours post-op, she complained of having lost all feeling on the non-operative leg. On examination, she had diminished both touch sensory and motor power on the non-operative leg, but intact on the operative side with VAS at 2/10. After Local Anesthetic Systemic Toxicity (LAST) was ruled out, epidural catheter was receded 2cm and the dose was lowered and paused. Despite of these adjustments after 4 hours, her experience was not improved. It was decided to use lipid emulsion as a challenging therapy. A vial of 250ml of Lipidem 20% (B. Braun) was infused over 30 min as regimen in ASRA's checklist for treatment of LAST. After completion of the lipid therapy, the sensory and movement of the non-operative leg regained normal after 60min. The severe pain recurred which needed IV morphine titration. The EA of 2-5ml/h was recontinued and effective for pain control for 3 days without no incident.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Lipid Emulsion for Local Anesthesia Reversal (LAR) after Prolonged Spinal/Epidural Anesthesia","attachmentId":57910132,"attachmentType":"pdf","work_url":"https://www.academia.edu/37900392/Lipid_Emulsion_for_Local_Anesthesia_Reversal_LAR_after_Prolonged_Spinal_Epidural_Anesthesia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/37900392/Lipid_Emulsion_for_Local_Anesthesia_Reversal_LAR_after_Prolonged_Spinal_Epidural_Anesthesia"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="37900487" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/37900487/Upper_Arm_Local_Anesthesia_Reversal_LAR_Using_Lipofundin_3_Case_Reports_">Upper Arm Local Anesthesia Reversal (LAR) Using Lipofundin (3 Case Reports)</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="95758512" href="https://independent.academia.edu/InnovationInfo">Innovationinfo Publishing</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Health Science and Development, 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">Local anesthesia reversal(LAR) is a new idea based on the history of Local Anesthetic Systemic Toxicity (LAST). If Intralipid and other specific Lipid emulsions can reverse the cardiac toxicity, why it cannot reverse other features connected to the local anesthesia toxicity?It is a very logical idea. The illogical issue is why it took almost 20 years from the first article on Intralipid and bupivacaine to invent it…? In our 3 cases the first patient " after finishing the lipofundin bolus injection after 4 mins (137 min after the brachial plexus block), she could move slightly her right finger.The patient could move her hand at 34 mins after the lipofundin bolus injection (166 mins after the brachial plexus block), and she could move her forearm 102 mins after the lipofundin bolus injection ". In the 2nd case " after 80-84 mins of the LE bolus injection (180 min after the brachial plexus block) the patient could move slightly his left thumb.After 184 mins since the lipid emulsion bolus injection (290 mins after the brachial block) the patient could move his hand and arm easily ". In the 3rd case " 85-87 mins after the LE bolus injection (220 min after the brachial plexus block), the patient could move slightly his arm. 128 mins after the lipid emulsion bolus injection (261 mins after the brachial plexus block), the patient could move his hand easily ". In all the 3 cases the reversal of the sensory and motor blocks were much faster than in the non-LAR cases as described in the medical literature. In that regards the LAR by Intralipid, Lipofundin and other similar lipid emulsions is a new method for postoperative care of patients after brachial plexus block. A 37 years old female was diagnosed an ununion radial bone. She performed a radial bone surgery on 1 st March 2018 at Military Hospital 103,Vietnam Military Medical University:http://www.csen.com/ upper4.JPG Patient was anesthetized by ultrasound guided brachial plexus block, upper clavicular approach with lidocaine 4 mg/kg combined with ropivacaine 1mg/kg and epinephrine 1/200.000 in a total volume of 30 ml.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Upper Arm Local Anesthesia Reversal (LAR) Using Lipofundin (3 Case Reports)","attachmentId":57910236,"attachmentType":"pdf","work_url":"https://www.academia.edu/37900487/Upper_Arm_Local_Anesthesia_Reversal_LAR_Using_Lipofundin_3_Case_Reports_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/37900487/Upper_Arm_Local_Anesthesia_Reversal_LAR_Using_Lipofundin_3_Case_Reports_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="37900342" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/37900342/Lipid_Emulsion_Treatment_for_Post_Spinal_Anesthesia_Myoclonus">Lipid Emulsion Treatment for Post Spinal Anesthesia Myoclonus</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="95758512" href="https://independent.academia.edu/InnovationInfo">Innovationinfo Publishing</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Health Science and Development, 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">Two case reports of myoclonus of legs post spinal anesthesia treated successfully by IV lipid emulsion are first described in the medical literature. A review of cases of myoclonus post regional anesthesia (spinal or epidural) are discussed with the hypothesis that the Lipid Emulsion effects are on the mitochondria and the intracellular calcium.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Lipid Emulsion Treatment for Post Spinal Anesthesia Myoclonus","attachmentId":57910064,"attachmentType":"pdf","work_url":"https://www.academia.edu/37900342/Lipid_Emulsion_Treatment_for_Post_Spinal_Anesthesia_Myoclonus","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/37900342/Lipid_Emulsion_Treatment_for_Post_Spinal_Anesthesia_Myoclonus"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="63350404" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/63350404/Systematic_review_of_the_effect_of_intravenous_lipid_emulsion_therapy_for_local_anesthetic_toxicity">Systematic review of the effect of intravenous lipid emulsion therapy for local anesthetic toxicity</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="52104935" href="https://independent.academia.edu/SheldonMagder">Sheldon Magder</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinical toxicology (Philadelphia, Pa.), 2016</p><p class="ds-related-work--abstract ds2-5-body-sm">Following national and regional recommendations, intravenous lipid emulsion (ILE) has become established in clinical practice as a treatment for acute local anesthetic (LA) toxicity, although evidence of efficacy is limited to animal studies and human case reports. A collaborative lipid emulsion workgroup was therefore established by the American Academy of Clinical Toxicology to review the evidence on the effect of ILE for LA toxicity. We performed a systematic review of the literature published through 15 December 2014. Relevant articles were determined based on pre-defined inclusion and exclusion criteria. Pre-treatment experiments, pharmacokinetic studies not involving toxicity and studies that did not address antidotal use of ILE were excluded. We included 113 studies and reports. Of these, 76 were human and 38 animal studies. One publication included both a human case report and an animal study. Human studies included one randomized controlled crossover trial involving 16 heal...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Systematic review of the effect of intravenous lipid emulsion therapy for local anesthetic toxicity","attachmentId":75809235,"attachmentType":"pdf","work_url":"https://www.academia.edu/63350404/Systematic_review_of_the_effect_of_intravenous_lipid_emulsion_therapy_for_local_anesthetic_toxicity","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/63350404/Systematic_review_of_the_effect_of_intravenous_lipid_emulsion_therapy_for_local_anesthetic_toxicity"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="35569813" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/35569813/KarnatakaAnaesthJ_Apnoes_during_spinal_anaesthesia_pdf">KarnatakaAnaesthJ Apnoes during spinal anaesthesia.pdf</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43200655" href="https://aiimsjodhpur.academia.edu/BharatPaliwal">Dr. Bharat Paliwal</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"KarnatakaAnaesthJ Apnoes during spinal anaesthesia.pdf","attachmentId":55436070,"attachmentType":"pdf","work_url":"https://www.academia.edu/35569813/KarnatakaAnaesthJ_Apnoes_during_spinal_anaesthesia_pdf","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/35569813/KarnatakaAnaesthJ_Apnoes_during_spinal_anaesthesia_pdf"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="82791834" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/82791834/Dentists_Knowledge_of_Local_Anesthetics_Local_Anesthetic_Toxicity_and_Lipid_Therapy_A_Survey_Study">Dentists' Knowledge of Local Anesthetics, Local Anesthetic Toxicity and Lipid Therapy: A Survey Study</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="189942642" href="https://independent.academia.edu/%C5%9E%C3%96zg%C3%BCnay">Şeyda Özgünay</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Ege University School of Dentistry, 2019</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Dentists' Knowledge of Local Anesthetics, Local Anesthetic Toxicity and Lipid Therapy: A Survey Study","attachmentId":88380193,"attachmentType":"pdf","work_url":"https://www.academia.edu/82791834/Dentists_Knowledge_of_Local_Anesthetics_Local_Anesthetic_Toxicity_and_Lipid_Therapy_A_Survey_Study","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/82791834/Dentists_Knowledge_of_Local_Anesthetics_Local_Anesthetic_Toxicity_and_Lipid_Therapy_A_Survey_Study"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="83032821" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/83032821/Lipid_emulsion_injection_induced_reversal_of_cardiac_toxicity_and_acceleration_of_emergence_from_general_anesthesia_after_scalp_infiltration_of_a_local_anesthetic_a_case_report">Lipid emulsion injection-induced reversal of cardiac toxicity and acceleration of emergence from general anesthesia after scalp infiltration of a local anesthetic: a case report</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33766931" href="https://uonuma-kikan-hospital.academia.edu/YoshinoriKamiya">Yoshinori Kamiya</a></div><p class="ds-related-work--metadata ds2-5-body-xs">JA Clinical Reports, 2017</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Lipid emulsion injection-induced reversal of cardiac toxicity and acceleration of emergence from general anesthesia after scalp infiltration of a local anesthetic: a case report","attachmentId":88526915,"attachmentType":"pdf","work_url":"https://www.academia.edu/83032821/Lipid_emulsion_injection_induced_reversal_of_cardiac_toxicity_and_acceleration_of_emergence_from_general_anesthesia_after_scalp_infiltration_of_a_local_anesthetic_a_case_report","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/83032821/Lipid_emulsion_injection_induced_reversal_of_cardiac_toxicity_and_acceleration_of_emergence_from_general_anesthesia_after_scalp_infiltration_of_a_local_anesthetic_a_case_report"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="98059330" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/98059330/Single_dose_lidocaine_spinal_anesthesia_in_hip_and_knee_arthroplasty">Single-dose lidocaine spinal anesthesia in hip and knee arthroplasty</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="41192708" href="https://independent.academia.edu/RichardBerger3">Richard Berger</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Arthroplasty today, 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">With the increasing interest in fast recovery and outpatient joint arthroplasty, short-acting local anesthetic agents and minimal narcotic use are preferred. Lidocaine is a fast-onset, short-duration local anesthetic that has been used for many years in spinal anesthesia. However, lidocaine spinal anesthesia has been reported to have a risk of transient neurologic symptoms (TNSs). The purpose of this study is to determine the safety and efficacy of single-dose lidocaine spinal anesthesia in the setting of outpatient joint arthroplasty. We performed a prospective study on 50 patients who received lidocaine spinal anesthesia in the setting of outpatient hip and knee arthroplasty. All patients received a single-shot spinal injection, with 2% isobaric lidocaine along with titrated propofol sedation. We evaluated demographic data, length of motor blockage, time to ambulation, time to discharge readiness, patient-reported symptoms of TNS. Of the 50 patients studied, 11 had total hip arthr...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Single-dose lidocaine spinal anesthesia in hip and knee arthroplasty","attachmentId":99514342,"attachmentType":"pdf","work_url":"https://www.academia.edu/98059330/Single_dose_lidocaine_spinal_anesthesia_in_hip_and_knee_arthroplasty","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/98059330/Single_dose_lidocaine_spinal_anesthesia_in_hip_and_knee_arthroplasty"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="90600627" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/90600627/Lipid_Emulsion_for_the_Treatment_of_Local_Anesthetic_Toxicity_Patient_Safety_Implications">Lipid Emulsion for the Treatment of Local Anesthetic Toxicity: Patient Safety Implications</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37190301" href="https://independent.academia.edu/SorinBrull">Sorin Brull</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Anesthesia & Analgesia, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Lipid Emulsion for the Treatment of Local Anesthetic Toxicity: Patient Safety Implications","attachmentId":94119885,"attachmentType":"pdf","work_url":"https://www.academia.edu/90600627/Lipid_Emulsion_for_the_Treatment_of_Local_Anesthetic_Toxicity_Patient_Safety_Implications","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/90600627/Lipid_Emulsion_for_the_Treatment_of_Local_Anesthetic_Toxicity_Patient_Safety_Implications"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":57910190,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":57910190,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_57910190" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="97882639" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/97882639/The_role_of_liposomal_bupivacaine_in_reduction_of_post_operative_pain_after_Transforaminal_Lumbar_Interbody_Fusion_TLIF_A_clinical_study">The role of liposomal bupivacaine in reduction of post-operative pain after Transforaminal Lumbar Interbody Fusion (TLIF): A clinical study</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="260005205" href="https://independent.academia.edu/PennyLiu8">Penny 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data-collection-position="3" data-entity-id="37900417" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/37900417/The_First_Case_Report_of_Local_Anesthesia_Reversal_LAR_of_the_Upper_Arm_Brachial_Plexus_Block_by_Lipid_Emulsion">The First Case Report of Local Anesthesia Reversal (LAR) of the Upper Arm Brachial Plexus Block by Lipid Emulsion</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="95758512" href="https://independent.academia.edu/InnovationInfo">Innovationinfo Publishing</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Health Science and Development, 2018</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The First Case Report of 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