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Tocriscreen Kinase Inhibitor 3.0 (7844) by Tocris, Part of Bio-Techne
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<li> Products </li> <li> <a href="/t/compound-libraries">Compound Libraries</a> </li> <li> <a href="/t/compound-libraries/small-molecules-peptides">Compound Libraries Small Molecules and Peptides</a> </li> <li> Tocriscreen Kinase Inhibitor 3.0 (7844) </li> </ol> </nav> </div> </div> </div> </div> <div class="row"> <div class="col-md-12"> <main> <section class="section"> <div> <div id="block-bio-techne-global-content" class="system_main_block"> <div class="top_region"><div class="mb-2 o___product-summary"><div id="pp-page-title-brand-wrapper"> <div id="header-subheader" data-section="section-base--header-subheader"> <div class="row" id="pp-page-title-brand-wrapper"> <div class="col-lg-9 col-md-12"> <h1 class="font-weight-bold"> Tocriscreen Kinase Inhibitor 3.0 </h1> <h2 class="font-weight-normal h4"> Tocris Bioscience, part of Bio-Techne <span id="product-code"> | Catalog # <span class="font-weight-bold">7844</span> </span> </h2> <div id="pp-reviews-citations-row"> <div id="header_left" class="row"> <div id="citation_quick_link_wrapper" class="col-auto d-flex align-self-center"> <div id="citation_quicklink"> <a href="#citations" id="citation_count" data-tab="2" class="citations"> <span class="icon-icon-product-citations d-none d-lg-inline pr-1"></span> Citations (38) </a> </div> </div> <div class="col-auto d-flex align-self-center"> <div> <a href="#product-documents" class="datasheet_link product-documents" rel="nofollow">COA / SDS</a> </div> </div> </div> </div> <div id="new_version_available"> </div> <div class="row mb-2" id="extended-description"> <div class="col-md-10 extended-description-wrapper" id="extended-description-wrapper"> A bioactive compound library of 210 kinase inhibitors (100 μL 10 mM DMSO solutions) for high-throughput screening, high-content screening, target validation and assay development </div> </div> </div> <div class="col-lg-3 col-md-12"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-tocris.svg" alt="Tocris Bioscience, part of Bio-Techne" class="d-flex h-100 w-100"> </div> </div> </div> </div> <div id="product_alerts_wrapper"><article class="product-data-wrapper"> </article> </div> </div> <div class="row border-top mb-2" id="images_atc_orderinfo_wrapper"><div class="col-xl-9 mt-2" id="image_atc_keydetails_wrapper"><div class="row" id="image_atc_wrapper"><div class="col-xl-4 order-xl-first" id="image_wrapper"><article class="product-data-wrapper"> <div class="image-slider-container"> <div class="product-image-lightbox tocris-image" data-brand="tocris"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="https://resources.bio-techne.com/images/products/7844_tocriscreen-kinase-inhibitor-3-0-compound-library.jpg" alt="" title="Kinase phylogenetic tree illustrating the pharmacological diversity of the Tocriscreen Kinase Inhibitor 3.0 Library." data-caption="The 210 compounds in the Tocriscreen Kinase Inhibitor 3.0 compound library target over 230 kinases. Targets are evenly spread across all the major IUPHAR kinase subfamilies, with a mix of well-established targets such as VEFGR and AKT, and “dark” kinases such as CDK19 and DYRK1B. To view a larger PDF version of this image, please click on the 'kinase tree' link in the product description." data-badges="" data-application="N/A" width="250" height="250" fetchpriority=high as=image class="search_result_thumbnail_image" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> <span class="image-count-text align-middle">(3)</span> </div> </div> </div> <i data-src="https://resources.bio-techne.com/images/products/7844_tocriscreen-kinase-inhibitor-3-0.png" data-alt="chemical diversity of the tocriscreen kinase inhibitor 3.0 compound library" title="Chemical diversity of the Tocriscreen Kinase Inhibitor 3.0 compound library." data-caption="The images show the overlapping chemical space of the 210 compounds in the Tocriscreen Kinase Inhibitor 3.0 compound library (green dots) in relation to the chemical space occupied by the ChEMBL kinase inhibitors (grey dots). Each dot represents a unique fingerprint generated from each compound's 3D molecular structure. The even distribution of the fingerprints of the compounds in the Tocriscreen Kinase Inhibitor 3.0 compound library highlights the chemical diversity of this library." data-badges="" data-application="N/A" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/7844_tocriscreen-kinase-inhibitor-3-0.jpg" data-alt="Tocriscreen Kinase Inhibitors logo" title="Tocriscreen Kinase Inhibitor 3.0 | A bioactive compound library of 210 kinase inhibitors (100 μL 10 mM DMSO solutions) for high-throughput screening, high-content screening and chemical biology application" data-caption="" data-badges="" data-application="N/A" data-width="250" data-height="250" class="none"></i> </div> </div> </article> </div> <div class="col-xl-8" id="atc_wrapper"><article class="product-data-wrapper"> <div class="atc-container"> <div class="atc-block" data-type="ds" data-blockid="ProductCart" > <form action="/commerce/addtocart" method="post" class="add-to-cart-block" data-productcode="7844"> <input type="hidden" name="print-quote" class="print-quote-input" value=""> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-3 font-weight-bold p-0">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-4 p-0 font-weight-bold d-none d-md-block">Availability</div> <div class="commerce-atc-price atc-head col-4 col-md-3 p-0 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-4 col-3 col-md-2 text-right font-weight-bold p-0">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart" class="atc-lines"> <div class="commerce-atc-ds-productline productline col-four row my-2 mx-0 text-left" data-catalog="7844/1 SET" data-hidden=""> <div class="commerce-atc-catnum col-3 col-md-3 pl-0 m-0">7844/1 SET</div> <div class="commerce-atc-availability col-md-4 pl-0 m-0 d-none d-md-block"> </div> <div class="commerce-atc-price col-4 col-md-3 pl-0 m-0"> </div> <div class="commerce-atc-quantity col-4 col-md-2 text-right px-0 m-0"> </div> </div> </div> <div class="atc-control ProductCart-control text-right"> <div class="row container d-flex justify-content-end mx-0 mb-3 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="" class="atc-print-quote-button btn btn-secondary m-1 col-xs-4 btn-md-block w-100">Print Quote</a> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=7844" class="atc-bulk-button btn btn-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </article> </div> </div> <div class="row datapoint_list border-top" id="key_details_wrapper"><div class="col-xl-12 mt-2" id="key_details_col_wrapper"></div> </div> </div> <div class="col-xl-3 mt-2" id="orderinfo_guarantee_wrapper"><div id="order_information_wrapper"><div id="product_shipping_block_wrapper" data-brand="tocris" data-shipping="" data-source="ep-data" data-sub_category_id="96"> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"><span class="sr-only">Loading...</span></div> </div> </div> <div id="video-tile-wrapper"><article class="product-data-wrapper"> <div class="video_tile_wrapper"> <article> <div> <lite-youtube videoid="J-YqGoL3m_c" style="background-image: url('https://resources.tocris.com/images/webinars/about-tocris-video.jpg');"> <a href="https://www.youtube.com/embed/J-YqGoL3m_c?autoplay=1" class="lty-playbtn" title="Introduction to Tocris"> <span class="lyt-visually-hidden">Introduction to Tocris</span> </a> </lite-youtube> </div> </article> </div> </article> </div> <div id="product_ads_wrapper"><article class="product-data-wrapper"> </article> </div> </div> </div> <div class="datapoint_list" id="key_details"><h3>Key Product Details</h3><table class=" table" id="key_details_table_wrapper"><tr class="product-data"> <td class="product-data-label py-2 align-top text-md-left">Description: </td> <td class="product-data-value py-2 align-top w-75 text-break"> A bioactive compound library of 210 kinase inhibitors (100 μL 10 mM DMSO solutions) for high-throughput screening, high-content screening, target validation and assay development </td> </tr> <tr class="product-data"> <td class="product-data-label py-2 align-top text-md-left">Key Format Details: </td> <td class="product-data-value py-2 align-top w-75 text-break"> <div style='float:left; width:50%'> <ul> <li>96-well racks with TrakMate tubes & SepraSeal caps</li> <li>Pre-dissolved in DMSO</li> <li>Compounds arranged 80 per rack with 3 racks per library</li> </ul> </div> <div style='float:left; width:50%'> <ul> <li>Many compounds are exclusive to Tocris</li> <li>Full chemical and biological data available</li> <li>Exceptional purity</li> </ul> </div> <div style='clear:left'></div> <img src='https://resources.tocris.com/images/tocriscreen/tocriscreen-kinase-inhibitor-library-target-classes.jpg' style='max-width:100%; margin:20px 0 10px 0' alt='Kinase subfamilies targeted by the Tocriscreen Kinase Inhibitor 3.0 library'> <p><strong>Major IUPHAR kinase subfamilies covered by Tocriscreen Kinase Inhibitor 3.0 Library</strong>. TK (tyrosine kinase, 29%); CMGC (includes CDK, MAPK, GSK3 and CLK families, 19%); TKL (tyrosine kinase-like, 16%); AGC (includes PKA, PKG and PKC families, 11%); Atypical (7%); CAMK, (calcium/calmodulin-dependent protein kinases, 4%) and Other Kinases (includes CAMKK, CK1 and STE, 14%).</p> </td> </tr> </table> </div> <div id="view_technical_detail_links"><div class="text-center"> <a id="view_technical" href="#technical-data-tab-tab">View Full Technical Details for Tocriscreen Kinase Inhibitor 3.0</a> </div> </div> </div> <div class="tab-content"><div id="about-data-tab-tab"></div> <ul class="nav nav-tabs nav-fill " id="productTab" role="tablist"> <li class="nav-item"> <a class="nav-link active" id="technical-data-tab-tab" href="#technical-data-tab" data-toggle="tab" role="tab" aria-controls="region-8571588723637" aria-selected="true" >Technical Data</a> </li> <li class="nav-item"> <a class="nav-link" id="citations-tab-tab" href="#citations-tab" data-toggle="tab" role="tab" aria-controls="region-3311588723784" aria-selected="false" >Citations</a> </li> </ul> <div class="tab-content rounded-bottom border-left border-right border-bottom mb-3" id="ProductTabContent"><div class="tab-pane fade show active mx-4" id="technical-data-tab" data-tab-label="Technical Data" role="tabpanel" aria-labelledby="technical-data-tab-tab"><div class="product_details_anchors"><div class="product-pages-anchors nav mx-0 pt-4 pb-2 m___nav-anchors d-none d-lg-flex"><li id="product-description_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor active" href="#product-description" id="product-description_li" >Product Description</a> </li> <li id="request-compound-list_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#request-compound-list" id="request-compound-list_li" >Request Compound List</a> </li> <li id="technical-data_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#technical-data" id="technical-data_li" >Technical Data</a> </li> <li id="references_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#references" id="references_li" >References</a> </li> <li id="product-documents_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 product-documents datasheet_static_link" href="#product-documents" id="product-documents_li" >Product Datasheets</a> </li> </div> <div id="product-description" class="nav-link px-0" data-anchor-label="Product Description"><div id="product_description_wrapper"><h3>Product Description for Tocriscreen Kinase Inhibitor 3.0</h3><div class="product-data-wrapper"> <p> Tocriscreen Kinase Inhibitor 3.0 compound library is a collection of 210 kinase inhibitors supplied pre-dissolved in DMSO (100 μL 10 mM solution). The Tocriscreen Kinase Inhibitor 3.0 Library contains compounds targeting >60 different kinases, including extensive coverage of well-established targets such as VEFGR and AKT, as well as novel targets such as Haspin and DYRK. The Tocriscreen Kinase Inhibitor 3.0 library is suitable for high-throughput screening (HTS), cell based high-content screening (HCS), target validation and assay development. Please view the <a href="https://resources.tocris.com/pdfs/guidelines/tocriscreen-kinase-inhibitor-pharm-diversity.pdf" title="View the kinase tree for Tocriscreen Kinase Inhibitor 3.0 Compound Library" target="_blank" class="a___link-external">kinase tree</a> image for a closer look at the pharmacological diversity of this compound library.<p>If this library does not suit your needs, please submit your requirements through our <a href="https://www.tocris.com/about-tocris/tocriscreen-pro-custom-compound-library-service" target="_blank" class="a___link-external">Tocriscreen PRO custom compound library service</a>.</p> </p> </div> </div> </div> <div id="request-compound-list" class="nav-link px-0" data-anchor-label="Request Compound List"><div id="request_compound_list_wrapper"> <h3>Request Compound List</h3> <p> A list of the compounds available in the Tocriscreen Kinase Inhibitor 3.0 can be requested in Excel or SD format via our <a rel="nofollow" target="_blank" href="https://www.tocris.com/support/screening-inquiry/">Tocriscreen & Custom Library Inquiries</a> form. </p> </div> </div> <div id="technical-data" class="nav-link px-0" data-anchor-label="Technical Data"><div id="technical_data_wrapper"><h3>Technical Data for Tocriscreen Kinase Inhibitor 3.0</h3><table class="tablesaw tablesaw-stack table-bordered table" id="technical_data_product-data-wrapper"><tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Storage</td> <td class="product-data-value p-3 px-4 text-break"> Store at -20°C </td> </tr> </table> <p class="small">The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.</p> <p class="small">Tocris products are intended for laboratory research use only, unless stated otherwise.</p> </div> </div> <div id="references" class="nav-link px-0" data-anchor-label="References"></div> <div id="product-datasheets-anchor" class="nav-link static-anchor p-0" data-anchor-label="Product Datasheets"></div> </div> </div> <div class="tab-pane fade mx-4 py-4" id="citations-tab" data-tab-label="Citations" role="tabpanel" aria-labelledby="citations-tab-tab"><div class="product_details_anchors mb-2"> <div class="nav mx-0 pt-4 pb-2 m___nav-anchors d-none d-lg-flex"> <li class="nav-item m-0"> <a class="nav-link jump-anchor active" href="#citations"> Citations </a> </li> </div> </div> <div id="citations"> <section id="citations-tab-content-placeholder" class="tab-content-placeholder" data-id="citations" data-product_code="7844"> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> </section> </div> </div> </div> </div> <div id="product-documents"> <div id="datasheet-accordion" class="accordion border mb-4"> <div class="rounded-top bg-white"> <h3 class="m-0 p-3">Product Documents for Tocriscreen Kinase Inhibitor 3.0</h3> </div> <div class="card-header"> <a data-toggle="collapse" data-target="#collapse_one" aria-expanded="false" class="collapsed" aria-controls="collapse_one"> <h5 class="mb-0"> COA </h5> </a> </div> <div id="collapse_one" class="collapse " aria-labelledby="heading_one" data-parent="#datasheet-accordion"> <div class="card-body"> Certificate of Analysis is currently unavailable on-line. Please contact <a href="/support/contact-us">Customer Service</a>. </div> </div> <div class="card-header"> <a class="collapsed" data-toggle="collapse" data-target="#collapse_three" aria-expanded="false" aria-controls="collapse_three" > <h5 class="mb-0"> SDS </h5> </a> </div> <div id="collapse_three" class="collapse rounded-bottom" aria-labelledby="heading_three" data-parent="#datasheet-accordion"> <div class="card-body"> <div class="row sds-row"> <div class="col text-bt-blue nowrap mt-3" id="sds-tocris-wrap"> <button id="sds_link" class="sds-link datasheet_link datasheet-button-link" data-uri="/sds-pdf-tocris?pdf=7844_sds.pdf"> Download SDS </button> </div> <div class="col-md-5 sds-pdf-result datasheet-loading"></div> </div> </div> </div> </div> </div> <div id="product-page-details" data-time-Total="0" data-time-ToCompile="0" data-time-ToBuild="0" data-time-Datapoints="0" data-time-Template="0" data-time-Post-EPCC="0" data-time-EPCC="0" data-renderTime="Friday 22nd of November 2024 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