CINXE.COM

<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="3eOpDhdJHEkc3EzHL76uYK+A/WPBO9nTRdAdlUhdEla+QN0wS2LZdV2Tx2QXVlbsONL1l8w7IoS96enHRTbzbQ==" /> <meta name="citation_title" content="Differential control of insulin secretion and somatostatin-receptor recruitment in isolated pancreatic islets" /> <meta name="citation_publication_date" content="1983/07/15" /> <meta name="citation_journal_title" content="Biochemical Journal" /> <meta name="citation_author" content="Harvey Pollard" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/125970477/Differential_control_of_insulin_secretion_and_somatostatin_receptor_recruitment_in_isolated_pancreatic_islets" /> <meta name="twitter:title" content="Differential control of insulin secretion and somatostatin-receptor recruitment in isolated pancreatic islets" /> <meta name="twitter:description" content="Academia.edu is a platform for academics to share research papers." /> <meta name="twitter:image" content="http://a.academia-assets.com/images/twitter-card.jpeg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/125970477/Differential_control_of_insulin_secretion_and_somatostatin_receptor_recruitment_in_isolated_pancreatic_islets" /> <meta property="og:title" content="Differential control of insulin secretion and somatostatin-receptor recruitment in isolated pancreatic islets" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="Differential control of insulin secretion and somatostatin-receptor recruitment in isolated pancreatic islets" /> <meta property="article:author" content="https://independent.academia.edu/HarveyPollard1" /> <meta name="description" content="Differential control of insulin secretion and somatostatin-receptor recruitment in isolated pancreatic islets" /> <title>(PDF) Differential control of insulin secretion and somatostatin-receptor recruitment in isolated pancreatic islets | Harvey Pollard - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/125970477/Differential_control_of_insulin_secretion_and_somatostatin_receptor_recruitment_in_isolated_pancreatic_islets" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = 'a780cc88a085c47718c74cbee01ed38f9303fee5'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1733268819000); window.Aedu.timeDifference = new Date().getTime() - 1733268819000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","author":[{"@context":"https://schema.org","@type":"Person","name":"Harvey Pollard"}],"contributor":[],"dateCreated":"2024-11-30","datePublished":"1983-07-15","headline":"Differential control of insulin secretion and somatostatin-receptor recruitment in isolated pancreatic islets","image":"https://attachments.academia-assets.com/119920343/thumbnails/1.jpg","inLanguage":"en","keywords":["Endocrinology","Kinetics","Biology","Medicine","Biological Sciences","Somatostatin","Internal Medicine","Glucose","Insulin","Biochemical","CHEMICAL SCIENCES","Promethazine","Rats","Receptor","Exocytosis","Arvicolinae","islets of Langerhans","Somatostatin Receptor","Medical and Health Sciences","In Vitro Techniques"],"publication":"Biochemical Journal","publisher":{"@context":"https://schema.org","@type":"Organization","name":"Portland Press"},"sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}],"thumbnailUrl":"https://attachments.academia-assets.com/119920343/thumbnails/1.jpg","url":"https://www.academia.edu/125970477/Differential_control_of_insulin_secretion_and_somatostatin_receptor_recruitment_in_isolated_pancreatic_islets"}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-102fa537001ba4d8dcd921ad9bd56c474abc201906ea4843e7e7efe9dfbf561d.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-8d679e925718b5e8e4b18e9a4fab37f7eaa99e43386459376559080ac8f2856a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/text_button-73590134e40cdb49f9abdc8e796cc00dc362693f3f0f6137d6cf9bb78c318ce7.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-10fa40af19d25203774df2d4a03b9b5771b45109c2304968038e88a81d1215c5.css" /> </head> <body> <div id='react-modal'></div> <div class="js-upgrade-ie-banner" style="display: none; text-align: center; padding: 8px 0; background-color: #ebe480;"><p style="color: #000; font-size: 12px; margin: 0 0 4px;">Academia.edu no longer supports Internet Explorer.</p><p style="color: #000; font-size: 12px; margin: 0;">To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.querySelector('.js-upgrade-ie-banner').style.display = 'block'; }</script> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "cee8a6af3b8e3dbcd469123a5a706bc27a8a5e892033b096a16f6a49ddae9732", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="868fLMbfJXz8cmOxxRAnGJIxDmAapmA4CO32x+2oPW2QDGsSmvTgQL096BL9+N+UBWMGlBemm2/w1AKV4MPcVg==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://www.academia.edu/125970477/Differential_control_of_insulin_secretion_and_somatostatin_receptor_recruitment_in_isolated_pancreatic_islets" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="LtSFne9skbMlhIjO/5dPbShBoZf6ZtghxIW0CpaxahxNd/Gjs0dUj2TLA23Hf7fhvxOpY/dmI3Y8vEBYm9qLJw==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><input class="btn btn-primary btn-block g-recaptcha js-password-reset-submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" type="submit" value="Email me a link" /></form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script> <div class="header--container" id="main-header-container"><div class="header--inner-container header--inner-container-ds2"><div class="header-ds2--left-wrapper"><div class="header-ds2--left-wrapper-inner"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="hide-on-desktop-redesign" style="height: 24px; width: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hide-on-mobile-redesign" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a><div class="header--search-container header--search-container-ds2"><form class="js-SiteSearch-form select2-no-default-pills" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><svg style="width: 14px; height: 14px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="search" class="header--search-icon svg-inline--fa fa-search fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M505 442.7L405.3 343c-4.5-4.5-10.6-7-17-7H372c27.6-35.3 44-79.7 44-128C416 93.1 322.9 0 208 0S0 93.1 0 208s93.1 208 208 208c48.3 0 92.7-16.4 128-44v16.3c0 6.4 2.5 12.5 7 17l99.7 99.7c9.4 9.4 24.6 9.4 33.9 0l28.3-28.3c9.4-9.4 9.4-24.6.1-34zM208 336c-70.7 0-128-57.2-128-128 0-70.7 57.2-128 128-128 70.7 0 128 57.2 128 128 0 70.7-57.2 128-128 128z"></path></svg><input class="header--search-input header--search-input-ds2 js-SiteSearch-form-input" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" /></form></div></div></div><nav class="header--nav-buttons header--nav-buttons-ds2 js-main-nav"><a class="ds2-5-button ds2-5-button--secondary js-header-login-url header-button-ds2 header-login-ds2 hide-on-mobile-redesign" href="https://www.academia.edu/login" rel="nofollow">Log In</a><a class="ds2-5-button ds2-5-button--secondary header-button-ds2 hide-on-mobile-redesign" href="https://www.academia.edu/signup" rel="nofollow">Sign Up</a><button class="header--hamburger-button header--hamburger-button-ds2 hide-on-desktop-redesign js-header-hamburger-button"><div class="icon-bar"></div><div class="icon-bar" style="margin-top: 4px;"></div><div class="icon-bar" style="margin-top: 4px;"></div></button></nav></div><ul class="header--dropdown-container js-header-dropdown"><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/login" rel="nofollow">Log In</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/signup" rel="nofollow">Sign Up</a></li><li class="header--dropdown-row js-header-dropdown-expand-button"><button class="header--dropdown-button">more<svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="caret-down" class="header--dropdown-button-icon svg-inline--fa fa-caret-down fa-w-10" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path fill="currentColor" d="M31.3 192h257.3c17.8 0 26.7 21.5 14.1 34.1L174.1 354.8c-7.8 7.8-20.5 7.8-28.3 0L17.2 226.1C4.6 213.5 13.5 192 31.3 192z"></path></svg></button></li><li><ul class="header--expanded-dropdown-container"><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/about">About</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/press">Press</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://medium.com/@academia">Blog</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/documents">Papers</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/terms">Terms</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/privacy">Privacy</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/copyright">Copyright</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/hiring"><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="header--dropdown-row-icon svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg>We're Hiring!</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://support.academia.edu/"><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="header--dropdown-row-icon svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg>Help Center</a></li><li class="header--dropdown-row js-header-dropdown-collapse-button"><button class="header--dropdown-button">less<svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="caret-up" class="header--dropdown-button-icon svg-inline--fa fa-caret-up fa-w-10" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path fill="currentColor" d="M288.662 352H31.338c-17.818 0-26.741-21.543-14.142-34.142l128.662-128.662c7.81-7.81 20.474-7.81 28.284 0l128.662 128.662c12.6 12.599 3.676 34.142-14.142 34.142z"></path></svg></button></li></ul></li></ul></div> <script src="//a.academia-assets.com/assets/webpack_bundles/fast_loswp-bundle-97865a4b41eebf6819eddc4c76d29598fe6b0336be57e9b6cde63060c39bfa02.js" defer="defer"></script><script>window.loswp = {}; window.loswp.author = 33654583; window.loswp.bulkDownloadFilterCounts = {}; window.loswp.hasDownloadableAttachment = true; window.loswp.hasViewableAttachments = true; // TODO: just use routes for this window.loswp.loginUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F125970477%2FDifferential_control_of_insulin_secretion_and_somatostatin_receptor_recruitment_in_isolated_pancreatic_islets%3Fauto%3Ddownload"; window.loswp.translateUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F125970477%2FDifferential_control_of_insulin_secretion_and_somatostatin_receptor_recruitment_in_isolated_pancreatic_islets%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":119920343,"identifier":"Attachment_119920343","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":125970477,"created_at":"2024-11-30T15:46:31.424-08:00","from_world_paper_id":261474345,"updated_at":"2024-11-30T16:13:04.201-08:00","_data":{"publisher":"Portland Press","publication_date":"1983,7,15","publication_name":"Biochemical Journal"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Differential control of insulin secretion and somatostatin-receptor recruitment in isolated pancreatic islets","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [33654583]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":119920343,"attachmentType":"pdf"}"><img alt="First page of “Differential control of insulin secretion and somatostatin-receptor recruitment in isolated pancreatic islets”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/119920343/mini_magick20241130-1-ik01aa.png?1733010708" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Differential control of insulin secretion and somatostatin-receptor recruitment in isolated pancreatic islets</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="33654583" href="https://independent.academia.edu/HarveyPollard1"><img alt="Profile image of Harvey Pollard" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Harvey Pollard</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">1983, Biochemical Journal</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">6 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 125970477; const worksViewsPath = "/v0/works/views?subdomain_param=api&work_ids%5B%5D=125970477"; const getWorkViews = async (workId) => { const response = await fetch(worksViewsPath); if (!response.ok) { throw new Error('Failed to load work views'); } const data = await response.json(); return data.views[workId]; }; // Get the view count for the work - we send this immediately rather than waiting for // the DOM to load, so it can be available as soon as possible (but without holding up // the backend or other resource requests, because it's a bit expensive and not critical). const viewCount = await getWorkViews(workId); const updateViewCount = (viewCount) => { const viewCountNumber = Number(viewCount); if (!viewCountNumber) { throw new Error('Failed to parse view count'); } const commaizedViewCount = viewCountNumber.toLocaleString(); const viewCountBody = document.getElementById('work-metadata-view-count'); if (viewCountBody) { viewCountBody.textContent = `${commaizedViewCount} views`; } else { throw new Error('Failed to find work views element'); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":119920343,"attachmentType":"pdf","workUrl":"https://www.academia.edu/125970477/Differential_control_of_insulin_secretion_and_somatostatin_receptor_recruitment_in_isolated_pancreatic_islets"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":119920343,"attachmentType":"pdf","workUrl":"https://www.academia.edu/125970477/Differential_control_of_insulin_secretion_and_somatostatin_receptor_recruitment_in_isolated_pancreatic_islets"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="119920343" data-landing_url="https://www.academia.edu/125970477/Differential_control_of_insulin_secretion_and_somatostatin_receptor_recruitment_in_isolated_pancreatic_islets" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="85762553" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/85762553/Dynamics_of_somatostatin_release_from_isolated_rat_pancreatic_islets">Dynamics of somatostatin release from isolated rat pancreatic islets</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="160638373" href="https://uni-freiburg.academia.edu/JannArends">Jann Arends</a></div><p class="ds-related-work--metadata ds2-5-body-xs">FEBS Letters, 1977</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Dynamics of somatostatin release from isolated rat pancreatic islets","attachmentId":90364664,"attachmentType":"pdf","work_url":"https://www.academia.edu/85762553/Dynamics_of_somatostatin_release_from_isolated_rat_pancreatic_islets","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/85762553/Dynamics_of_somatostatin_release_from_isolated_rat_pancreatic_islets"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="66678279" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/66678279/Solubilization_of_somatostatin_receptors_in_hamster_pancreatic_beta_cells">Solubilization of somatostatin receptors in hamster pancreatic beta cells</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37144652" href="https://univ-paris7.academia.edu/JeanclaudeMarie">Jean-claude Marie</a></div><p class="ds-related-work--metadata ds2-5-body-xs">European Journal …, 1989</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Solubilization of somatostatin receptors in hamster pancreatic beta cells","attachmentId":77776899,"attachmentType":"pdf","work_url":"https://www.academia.edu/66678279/Solubilization_of_somatostatin_receptors_in_hamster_pancreatic_beta_cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/66678279/Solubilization_of_somatostatin_receptors_in_hamster_pancreatic_beta_cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="6144527" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/6144527/Stimulation_and_inhibition_of_insulin_release_by_an_amino_reactive_probe_of_plasma_membrane">Stimulation and inhibition of insulin release by an amino-reactive probe of plasma membrane</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42200675" href="https://independent.academia.edu/BoHellman">Bo Hellman</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="9330913" href="https://umu.academia.edu/IngeBertT%C3%A4ljedal">Inge-Bert Täljedal</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Membrane Biology, 1973</p><p class="ds-related-work--abstract ds2-5-body-sm">4-Acetamido-4′-isothiocyanostilbene-2,2′-disulphonic acid (SITS), an amino-reacting probe of plasma membranes, stimulated the release of insulin from micro-dissected pancreatic islets ofob/ob-mice. This effect of SITS was inhibited by adrenaline or by calcium deficiency. SITS did not inhibit the insulin-releasing action of glucose or leucine but rather potentiated the effect of glucose. In contrast, SITS markedly depressed the insulin secretory response to chloromercuribenzene-p-sulphonic acid. It is suggested that by reacting with the plasma membranes SITS may induce secretagogic ionic fluxes in the β-cells. In addition, SITS apparently inhibits the secretagogic recognition of chloromercuribenzene-p-sulphonic acid, presumably by preventing the organic mercurial from reacting with certain membrane thiol groups.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Stimulation and inhibition of insulin release by an amino-reactive probe of plasma membrane","attachmentId":49000614,"attachmentType":"pdf","work_url":"https://www.academia.edu/6144527/Stimulation_and_inhibition_of_insulin_release_by_an_amino_reactive_probe_of_plasma_membrane","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/6144527/Stimulation_and_inhibition_of_insulin_release_by_an_amino_reactive_probe_of_plasma_membrane"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="16763962" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/16763962/Characterization_of_Somatostatin_Receptor_Subtype_Specific_Regulation_of_Insulin_and_Glucagon_Secretion_An_in_Vitro_Study_on_Isolated_Human_Pancreatic_Islets">Characterization of Somatostatin Receptor Subtype-Specific Regulation of Insulin and Glucagon Secretion: An in Vitro Study on Isolated Human Pancreatic Islets</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36191706" href="https://charite-de.academia.edu/UrsulaPl%C3%B6ckinger">Ursula Plöckinger</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Clinical Endocrinology & Metabolism, 2007</p><p class="ds-related-work--abstract ds2-5-body-sm">Pancreatic A- and B-cells express somatostatin receptors (SSTRs). Five pharmacologically distinct SSTR subtypes are known (SSTR1-SSTR5). In rodents, SSTR2 inhibits glucagon secretion, whereas SSTR5 suppresses the release of insulin. Human pancreatic A- and B-cells express SSTR1-3 and SSTR5; however, their contribution to the regulation of glucagon and insulin secretion is not well known. The goal of this study was to characterize the role of individual SSTR subtypes in regulating human glucagon and insulin secretion in vitro. Human pancreatic islets were isolated from healthy donors and incubated with somatostatin, SSTR1-3-selective and SSTR5-selective agonists, or an SSTR2-selective antagonist (DC-41-33). Stimulation of insulin secretion was induced by glucose (10, 20 mm) alone or in combination with 10 nm exendin-4 or 10 mm L-arginine. Glucagon secretion was induced by 20 mm L-arginine. Basal secretion of insulin and glucagon was measured at 2.8 or 3.3 mm glucose. SSTR1-, SSTR2-, and SSTR5-selective agonists inhibited insulin secretion with the following order of potency: SSTR2 (EC50, 0.08 nm) &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; SSTR5 (EC50, 5.3 nm) &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; SSTR1 (EC50, 35 nm). Glucagon secretion was inhibited by SSTR-selective agonists with the following order of potency: SSTR2 (EC50, 0.05 nm) &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; SSTR1 (EC50, 1.8 nm) &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; SSTR5 (EC50, 28 nm). DC-41-33 dose-dependently reversed the effects of the SSTR2-selective agonist on insulin and glucagon secretion. Our study demonstrates that SSTR2-agonist is the most potent inhibitor of insulin and glucagon secretion from isolated human pancreatic islets. Furthermore, we identify SSTR1- and SSTR5-selective agonists as additional inhibitors of insulin and glucagon secretion from human pancreas.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Characterization of Somatostatin Receptor Subtype-Specific Regulation of Insulin and Glucagon Secretion: An in Vitro Study on Isolated Human Pancreatic Islets","attachmentId":42402203,"attachmentType":"pdf","work_url":"https://www.academia.edu/16763962/Characterization_of_Somatostatin_Receptor_Subtype_Specific_Regulation_of_Insulin_and_Glucagon_Secretion_An_in_Vitro_Study_on_Isolated_Human_Pancreatic_Islets","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/16763962/Characterization_of_Somatostatin_Receptor_Subtype_Specific_Regulation_of_Insulin_and_Glucagon_Secretion_An_in_Vitro_Study_on_Isolated_Human_Pancreatic_Islets"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="70177968" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/70177968/Glucose_stimulation_of_somatostatin_and_insulin_release_from_the_isolated_perfused_rat_pancreas">Glucose stimulation of somatostatin and insulin release from the isolated, perfused rat pancreas</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="44577716" href="https://independent.academia.edu/RobertElde">Robert Elde</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Diabetes, 1980</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Glucose stimulation of somatostatin and insulin release from the isolated, perfused rat pancreas","attachmentId":80025487,"attachmentType":"pdf","work_url":"https://www.academia.edu/70177968/Glucose_stimulation_of_somatostatin_and_insulin_release_from_the_isolated_perfused_rat_pancreas","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/70177968/Glucose_stimulation_of_somatostatin_and_insulin_release_from_the_isolated_perfused_rat_pancreas"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="59415860" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/59415860/Somatostatin_inhibits_insulin_release_via_SSTR2_in_hamster_clonal_%CE%B2_cells_and_pancreatic_islets">Somatostatin inhibits insulin release via SSTR2 in hamster clonal β-cells and pancreatic islets</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42429872" href="https://independent.academia.edu/WHsu4">W. Hsu</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Regulatory Peptides, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Somatostatin inhibits insulin release via SSTR2 in hamster clonal β-cells and pancreatic islets","attachmentId":73350173,"attachmentType":"pdf","work_url":"https://www.academia.edu/59415860/Somatostatin_inhibits_insulin_release_via_SSTR2_in_hamster_clonal_%CE%B2_cells_and_pancreatic_islets","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/59415860/Somatostatin_inhibits_insulin_release_via_SSTR2_in_hamster_clonal_%CE%B2_cells_and_pancreatic_islets"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="55877478" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/55877478/Paracrine_regulation_of_somatostatin_secretion_by_insulin_and_glucagon_in_mouse_pancreatic_islets">Paracrine regulation of somatostatin secretion by insulin and glucagon in mouse pancreatic islets</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32489242" href="https://ku-dk.academia.edu/JensJuulHolst">Jens Juul Holst</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Diabetologia</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Paracrine regulation of somatostatin secretion by insulin and glucagon in mouse pancreatic islets","attachmentId":71538476,"attachmentType":"pdf","work_url":"https://www.academia.edu/55877478/Paracrine_regulation_of_somatostatin_secretion_by_insulin_and_glucagon_in_mouse_pancreatic_islets","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/55877478/Paracrine_regulation_of_somatostatin_secretion_by_insulin_and_glucagon_in_mouse_pancreatic_islets"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="52661445" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/52661445/Colocalization_of_Somatostatin_Receptor_sst5_and_Insulin_in_Rat_Pancreatic_%CE%B2_Cells_1">Colocalization of Somatostatin Receptor sst5 and Insulin in Rat Pancreatic β-Cells 1</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="14436250" href="https://nih.academia.edu/EvaMezey">Eva Mezey</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Endocrinology, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Colocalization of Somatostatin Receptor sst5 and Insulin in Rat Pancreatic β-Cells 1","attachmentId":69819262,"attachmentType":"pdf","work_url":"https://www.academia.edu/52661445/Colocalization_of_Somatostatin_Receptor_sst5_and_Insulin_in_Rat_Pancreatic_%CE%B2_Cells_1","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/52661445/Colocalization_of_Somatostatin_Receptor_sst5_and_Insulin_in_Rat_Pancreatic_%CE%B2_Cells_1"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="79394781" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/79394781/Proportional_inhibition_of_glucose_induced_insulin_release_by_somatostatin">Proportional inhibition of glucose-induced insulin release by somatostatin</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="60948696" href="https://independent.academia.edu/GeraldTaborsky">Gerald Taborsky</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Metabolism, 1980</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Proportional inhibition of glucose-induced insulin release by somatostatin","attachmentId":86124623,"attachmentType":"pdf","work_url":"https://www.academia.edu/79394781/Proportional_inhibition_of_glucose_induced_insulin_release_by_somatostatin","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/79394781/Proportional_inhibition_of_glucose_induced_insulin_release_by_somatostatin"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="25757285" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/25757285/Somatostatin_receptors_on_rat_pancreatic_acinar_cells_Pharmacological_and_structural_characterization_and_demonstration_of_down_regulation_in_streptozotocin_diabetes">Somatostatin receptors on rat pancreatic acinar cells. Pharmacological and structural characterization and demonstration of down-regulation in streptozotocin diabetes</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="49494414" href="https://independent.academia.edu/CoimbatoreSrikant">Coimbatore Srikant</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of biological chemistry, 1986</p><p class="ds-related-work--abstract ds2-5-body-sm">The binding of somatostatin-14 (S-14) to rat pancreatic acinar cell membranes was characterized using [125I-Tyr11]S-14 as the radioligand. Maximum binding was observed at pH 7.4 and was Ca2+-dependent. Such Ca2+ dependence of S-14 receptor binding was not observed in other tissues. Scatchard analysis of the competitive inhibition by S-14 of [125I-Tyr11]S-14 binding revealed a single class of high affinity sites (Kd = 0.5 +/- 0.07 nM) with a binding capacity (Bmax) of 266 +/- 22 fmol/mg of protein. [D-Trp8]S-14 and structural analogs with halogenated Trp moiety exhibited 2-32-fold greater binding affinity than S-14, [D-F5-Trp8]S-14 being the most potent. [Tyr11]S-14 was equipotent with S-14. The affinity of somatostatin-28 for binding to these receptors was 50% of that of S-14. Cholecystokinin octapeptide (CCK-8) inhibited the binding of [125I-Tyr11]S-14, but its inhibition curve was not parallel to that of S-14. In the presence of 1 nM CCK-8, the Bmax of S-14 receptors was reduced t...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Somatostatin receptors on rat pancreatic acinar cells. Pharmacological and structural characterization and demonstration of down-regulation in streptozotocin diabetes","attachmentId":46113106,"attachmentType":"pdf","work_url":"https://www.academia.edu/25757285/Somatostatin_receptors_on_rat_pancreatic_acinar_cells_Pharmacological_and_structural_characterization_and_demonstration_of_down_regulation_in_streptozotocin_diabetes","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/25757285/Somatostatin_receptors_on_rat_pancreatic_acinar_cells_Pharmacological_and_structural_characterization_and_demonstration_of_down_regulation_in_streptozotocin_diabetes"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":119920343,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":119920343,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_119920343" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="23506550" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/23506550/Somatostatin_Secreted_by_Islet_Cells_Fulfills_Multiple_Roles_as_a_Paracrine_Regulator_of_Islet_Function">Somatostatin Secreted by Islet -Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="45603229" href="https://independent.academia.edu/MChristie1">M. Christie</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="45512776" href="https://independent.academia.edu/AstridHaugeEvans">Astrid Hauge-Evans</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Diabetes, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Somatostatin Secreted by Islet -Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function","attachmentId":43943118,"attachmentType":"pdf","work_url":"https://www.academia.edu/23506550/Somatostatin_Secreted_by_Islet_Cells_Fulfills_Multiple_Roles_as_a_Paracrine_Regulator_of_Islet_Function","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/23506550/Somatostatin_Secreted_by_Islet_Cells_Fulfills_Multiple_Roles_as_a_Paracrine_Regulator_of_Islet_Function"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="125935906" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/125935906/Effect_of_Insulin_on_Glucose_and_Arginine_Stimulated_Somatostatin_Secretion_from_the_Isolated_Perfused_Rat_Pancreas_">Effect of Insulin on Glucose- and Arginine-Stimulated Somatostatin Secretion from the Isolated Perfused Rat Pancreas*</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36058684" href="https://independent.academia.edu/ElisabethTrimble">Elisabeth Trimble</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Endocrinology, 1981</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effect of Insulin on Glucose- and Arginine-Stimulated Somatostatin Secretion from the Isolated Perfused Rat Pancreas*","attachmentId":119891658,"attachmentType":"pdf","work_url":"https://www.academia.edu/125935906/Effect_of_Insulin_on_Glucose_and_Arginine_Stimulated_Somatostatin_Secretion_from_the_Isolated_Perfused_Rat_Pancreas_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/125935906/Effect_of_Insulin_on_Glucose_and_Arginine_Stimulated_Somatostatin_Secretion_from_the_Isolated_Perfused_Rat_Pancreas_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="84028448" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/84028448/Colocalization_of_Somatostatin_Receptor_sst5_and_Insulin_in_Rat_Pancreatic_b_Cells_">Colocalization of Somatostatin Receptor sst5 and Insulin in Rat Pancreatic b-Cells*</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34138756" href="https://independent.academia.edu/ForrestFoor">Forrest Foor</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2015</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Colocalization of Somatostatin Receptor sst5 and Insulin in Rat Pancreatic b-Cells*","attachmentId":89187788,"attachmentType":"pdf","work_url":"https://www.academia.edu/84028448/Colocalization_of_Somatostatin_Receptor_sst5_and_Insulin_in_Rat_Pancreatic_b_Cells_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/84028448/Colocalization_of_Somatostatin_Receptor_sst5_and_Insulin_in_Rat_Pancreatic_b_Cells_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="22680300" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/22680300/Somatostatin_release_electrical_activity_membrane_currents_and_exocytosis_in_human_pancreatic_delta_cells">Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="44290206" href="https://oxford.academia.edu/RRamracheya">R. Ramracheya</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Diabetologia, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells","attachmentId":43262818,"attachmentType":"pdf","work_url":"https://www.academia.edu/22680300/Somatostatin_release_electrical_activity_membrane_currents_and_exocytosis_in_human_pancreatic_delta_cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/22680300/Somatostatin_release_electrical_activity_membrane_currents_and_exocytosis_in_human_pancreatic_delta_cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="4" data-entity-id="670874" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/670874/Somatostatin_secreted_by_islet_%CE%B4_cells_fulfills_multiple_roles_as_a_paracrine_regulator_of_islet_function">Somatostatin secreted by islet δ-cells fulfills multiple roles as a paracrine regulator of islet function</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="213659" href="https://kcl.academia.edu/AileenKing">Aileen King</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Diabetes, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Somatostatin secreted by islet δ-cells fulfills multiple roles as a paracrine regulator of islet function","attachmentId":51301145,"attachmentType":"pdf","work_url":"https://www.academia.edu/670874/Somatostatin_secreted_by_islet_%CE%B4_cells_fulfills_multiple_roles_as_a_paracrine_regulator_of_islet_function","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/670874/Somatostatin_secreted_by_islet_%CE%B4_cells_fulfills_multiple_roles_as_a_paracrine_regulator_of_islet_function"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="5" data-entity-id="47726597" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/47726597/The_pancreatic_%CE%B2_cell_recognition_of_insulin_secretagogues">The pancreatic β-cell recognition of insulin secretagogues</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42200675" href="https://independent.academia.edu/BoHellman">Bo Hellman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Archives of Biochemistry and Biophysics, 1974</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The pancreatic β-cell recognition of insulin secretagogues","attachmentId":66674055,"attachmentType":"pdf","work_url":"https://www.academia.edu/47726597/The_pancreatic_%CE%B2_cell_recognition_of_insulin_secretagogues","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/47726597/The_pancreatic_%CE%B2_cell_recognition_of_insulin_secretagogues"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="6" data-entity-id="23506556" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/23506556/A_role_for_islet_somatostatin_in_mediating_sympathetic_regulation_of_glucagon_secretion">A role for islet somatostatin in mediating sympathetic regulation of glucagon secretion</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="45512776" href="https://independent.academia.edu/AstridHaugeEvans">Astrid Hauge-Evans</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Islets, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A role for islet somatostatin in mediating sympathetic regulation of glucagon secretion","attachmentId":43943125,"attachmentType":"pdf","work_url":"https://www.academia.edu/23506556/A_role_for_islet_somatostatin_in_mediating_sympathetic_regulation_of_glucagon_secretion","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/23506556/A_role_for_islet_somatostatin_in_mediating_sympathetic_regulation_of_glucagon_secretion"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="7" data-entity-id="50297627" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/50297627/On_insulin_secretion">On insulin secretion</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="9330913" href="https://umu.academia.edu/IngeBertT%C3%A4ljedal">Inge-Bert Täljedal</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Diabetologia, 1981</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"On insulin secretion","attachmentId":68336638,"attachmentType":"pdf","work_url":"https://www.academia.edu/50297627/On_insulin_secretion","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/50297627/On_insulin_secretion"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="8" data-entity-id="73948157" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/73948157/Insulin_Secretion_Functional_Biochemical_Aspects_Insulin_Action_Post_Receptor_Mechanisms">Insulin Secretion, Functional Biochemical Aspects,Insulin Action, Post-Receptor Mechanisms</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="217700055" href="https://independent.academia.edu/moawadwael">wael moawad</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Insulin Secretion, Functional Biochemical Aspects,Insulin Action, Post-Receptor Mechanisms","attachmentId":82280281,"attachmentType":"pdf","work_url":"https://www.academia.edu/73948157/Insulin_Secretion_Functional_Biochemical_Aspects_Insulin_Action_Post_Receptor_Mechanisms","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/73948157/Insulin_Secretion_Functional_Biochemical_Aspects_Insulin_Action_Post_Receptor_Mechanisms"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="9" data-entity-id="20571971" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/20571971/Insulin_as_a_surface_marker_on_isolated_cells_from_rat_pancreatic_islets">Insulin as a surface marker on isolated cells from rat pancreatic islets</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="41925814" href="https://independent.academia.edu/JerryColca">Jerry Colca</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Cell Biology</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Insulin as a surface marker on isolated cells from rat pancreatic islets","attachmentId":41443894,"attachmentType":"pdf","work_url":"https://www.academia.edu/20571971/Insulin_as_a_surface_marker_on_isolated_cells_from_rat_pancreatic_islets","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/20571971/Insulin_as_a_surface_marker_on_isolated_cells_from_rat_pancreatic_islets"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="10" data-entity-id="66678294" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/66678294/Solubilization_and_Partial_Purification_of_Somatostatin_28_Preferring_Receptors_from_Hamster_Pancreatic_8_Cells_">Solubilization and Partial Purification of Somatostatin-28 Preferring Receptors from Hamster Pancreatic , 8 Cells *</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37144652" href="https://univ-paris7.academia.edu/JeanclaudeMarie">Jean-claude Marie</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2001</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Solubilization and Partial Purification of Somatostatin-28 Preferring Receptors from Hamster Pancreatic , 8 Cells *","attachmentId":77776821,"attachmentType":"pdf","work_url":"https://www.academia.edu/66678294/Solubilization_and_Partial_Purification_of_Somatostatin_28_Preferring_Receptors_from_Hamster_Pancreatic_8_Cells_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/66678294/Solubilization_and_Partial_Purification_of_Somatostatin_28_Preferring_Receptors_from_Hamster_Pancreatic_8_Cells_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="11" data-entity-id="57488621" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/57488621/The_stimulus_secretion_coupling_of_glucose_induced_insulin_release_XLVI_Physiological_role_of_glutamine_as_a_fuel_for_pancreatic_islets">The stimulus-secretion coupling of glucose-induced insulin release XLVI. Physiological role of-glutamine as a fuel for pancreatic islets</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33070983" href="https://independent.academia.edu/%C3%82ngeloCarpinelli">Ângelo Carpinelli</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Molecular and Cellular …, 1980</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The stimulus-secretion coupling of glucose-induced insulin release XLVI. Physiological role of-glutamine as a fuel for pancreatic islets","attachmentId":72367960,"attachmentType":"pdf","work_url":"https://www.academia.edu/57488621/The_stimulus_secretion_coupling_of_glucose_induced_insulin_release_XLVI_Physiological_role_of_glutamine_as_a_fuel_for_pancreatic_islets","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/57488621/The_stimulus_secretion_coupling_of_glucose_induced_insulin_release_XLVI_Physiological_role_of_glutamine_as_a_fuel_for_pancreatic_islets"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="12" data-entity-id="20571972" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/20571972/Effect_of_insulin_secretagogues_and_potential_modulators_of_secretion_on_a_plasma_membrane_Ca2_Mg2_ATPase_activity_in_islets_of_langerhans_1">Effect of insulin secretagogues and potential modulators of secretion on a plasma membrane (Ca2+ + Mg2+)-ATPase activity in islets of langerhans*1</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="41925814" href="https://independent.academia.edu/JerryColca">Jerry Colca</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Archives of Biochemistry and Biophysics, 1985</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effect of insulin secretagogues and potential modulators of secretion on a plasma membrane (Ca2+ + Mg2+)-ATPase activity in islets of langerhans*1","attachmentId":41943564,"attachmentType":"pdf","work_url":"https://www.academia.edu/20571972/Effect_of_insulin_secretagogues_and_potential_modulators_of_secretion_on_a_plasma_membrane_Ca2_Mg2_ATPase_activity_in_islets_of_langerhans_1","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/20571972/Effect_of_insulin_secretagogues_and_potential_modulators_of_secretion_on_a_plasma_membrane_Ca2_Mg2_ATPase_activity_in_islets_of_langerhans_1"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="13" data-entity-id="55034150" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/55034150/Co_ordinated_Ca2_signalling_within_pancreatic_islets_does_%CE%B2_cell_entrainment_require_a_secreted_messenger">Co-ordinated Ca2+-signalling within pancreatic islets: does β-cell entrainment require a secreted messenger</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32632325" href="https://ulincoln.academia.edu/PaulSquires">Paul Squires</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cell Calcium, 2002</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Co-ordinated Ca2+-signalling within pancreatic islets: does β-cell entrainment require a secreted messenger","attachmentId":71102698,"attachmentType":"pdf","work_url":"https://www.academia.edu/55034150/Co_ordinated_Ca2_signalling_within_pancreatic_islets_does_%CE%B2_cell_entrainment_require_a_secreted_messenger","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/55034150/Co_ordinated_Ca2_signalling_within_pancreatic_islets_does_%CE%B2_cell_entrainment_require_a_secreted_messenger"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="14" data-entity-id="106846168" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/106846168/Pulses_of_somatostatin_release_are_slightly_delayed_compared_with_insulin_and_antisynchronous_to_glucagon">Pulses of somatostatin release are slightly delayed compared with insulin and antisynchronous to glucagon</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="146181832" href="https://independent.academia.edu/EvaGrapengiesser">Eva Grapengiesser</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Regulatory Peptides, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Pulses of somatostatin release are slightly delayed compared with insulin and antisynchronous to glucagon","attachmentId":105813766,"attachmentType":"pdf","work_url":"https://www.academia.edu/106846168/Pulses_of_somatostatin_release_are_slightly_delayed_compared_with_insulin_and_antisynchronous_to_glucagon","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/106846168/Pulses_of_somatostatin_release_are_slightly_delayed_compared_with_insulin_and_antisynchronous_to_glucagon"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="15" data-entity-id="118144580" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/118144580/Intracellular_degradation_of_somatostatin_14_following_somatostatin_receptor_3_mediated_endocytosis_in_rat_insulinoma_cells">Intracellular degradation of somatostatin‐14 following somatostatin‐receptor 3‐mediated endocytosis in rat insulinoma cells</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="273569988" href="https://independent.academia.edu/OKreuzer">Oliver Kreuzer</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The FEBS Journal, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Intracellular degradation of somatostatin‐14 following somatostatin‐receptor 3‐mediated endocytosis in rat insulinoma cells","attachmentId":113839409,"attachmentType":"pdf","work_url":"https://www.academia.edu/118144580/Intracellular_degradation_of_somatostatin_14_following_somatostatin_receptor_3_mediated_endocytosis_in_rat_insulinoma_cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/118144580/Intracellular_degradation_of_somatostatin_14_following_somatostatin_receptor_3_mediated_endocytosis_in_rat_insulinoma_cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="16" data-entity-id="20571923" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/20571923/Effect_of_insulin_secretagogues_and_potential_modulators_of_secretion_on_a_plasma_membrane_Ca2_Mg2_ATPase_activity_in_islets_of_langerhans">Effect of insulin secretagogues and potential modulators of secretion on a plasma membrane (Ca2+ + Mg2+)-ATPase activity in islets of langerhans</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="41925814" href="https://independent.academia.edu/JerryColca">Jerry Colca</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Archives of Biochemistry and Biophysics, 1985</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effect of insulin secretagogues and potential modulators of secretion on a plasma membrane (Ca2+ + Mg2+)-ATPase activity in islets of langerhans","attachmentId":41943572,"attachmentType":"pdf","work_url":"https://www.academia.edu/20571923/Effect_of_insulin_secretagogues_and_potential_modulators_of_secretion_on_a_plasma_membrane_Ca2_Mg2_ATPase_activity_in_islets_of_langerhans","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/20571923/Effect_of_insulin_secretagogues_and_potential_modulators_of_secretion_on_a_plasma_membrane_Ca2_Mg2_ATPase_activity_in_islets_of_langerhans"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="17" data-entity-id="118117825" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/118117825/Isolated_mouse_islets_respond_to_glucose_with_an_initial_peak_of_glucagon_release_followed_by_pulses_of_insulin_and_somatostatin_in_antisynchrony_with_glucagon">Isolated mouse islets respond to glucose with an initial peak of glucagon release followed by pulses of insulin and somatostatin in antisynchrony with glucagon</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="146181832" href="https://independent.academia.edu/EvaGrapengiesser">Eva Grapengiesser</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochemical and Biophysical Research Communications, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Isolated mouse islets respond to glucose with an initial peak of glucagon release followed by pulses of insulin and somatostatin in antisynchrony with glucagon","attachmentId":113817917,"attachmentType":"pdf","work_url":"https://www.academia.edu/118117825/Isolated_mouse_islets_respond_to_glucose_with_an_initial_peak_of_glucagon_release_followed_by_pulses_of_insulin_and_somatostatin_in_antisynchrony_with_glucagon","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/118117825/Isolated_mouse_islets_respond_to_glucose_with_an_initial_peak_of_glucagon_release_followed_by_pulses_of_insulin_and_somatostatin_in_antisynchrony_with_glucagon"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="18" data-entity-id="62528489" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/62528489/Pancreatic_islet_cells_A_model_for_calcium_dependent_peptide_release">Pancreatic islet cells: A model for calcium‐dependent peptide release</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="155973091" href="https://independent.academia.edu/SoriaBernat">Bernat Soria</a></div><p class="ds-related-work--metadata ds2-5-body-xs">HFSP Journal, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Pancreatic islet cells: A model for calcium‐dependent peptide release","attachmentId":75258668,"attachmentType":"pdf","work_url":"https://www.academia.edu/62528489/Pancreatic_islet_cells_A_model_for_calcium_dependent_peptide_release","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/62528489/Pancreatic_islet_cells_A_model_for_calcium_dependent_peptide_release"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="19" data-entity-id="62544064" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/62544064/Effects_of_calcium_buffering_on_glucose_induced_insulin_release_in_mouse_pancreatic_islets_an_approximation_to_the_calcium_sensor">Effects of calcium buffering on glucose-induced insulin release in mouse pancreatic islets: an approximation to the calcium sensor</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="155973091" href="https://independent.academia.edu/SoriaBernat">Bernat Soria</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Physiology, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effects of calcium buffering on glucose-induced insulin release in mouse pancreatic islets: an approximation to the calcium sensor","attachmentId":75269747,"attachmentType":"pdf","work_url":"https://www.academia.edu/62544064/Effects_of_calcium_buffering_on_glucose_induced_insulin_release_in_mouse_pancreatic_islets_an_approximation_to_the_calcium_sensor","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/62544064/Effects_of_calcium_buffering_on_glucose_induced_insulin_release_in_mouse_pancreatic_islets_an_approximation_to_the_calcium_sensor"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="20" data-entity-id="116399350" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/116399350/Stimulation_by_2_deoxy_scp_d_scp_glucose_tetraacetates_of_hormonal_secretion_from_the_perfused_rat_pancreas">Stimulation by 2-deoxy-<scp>d</scp>-glucose tetraacetates of hormonal secretion from the perfused rat pancreas</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42458577" href="https://independent.academia.edu/MarcelMbiyanganduKadiata">Marcel Mbiyangandu Kadiata</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American Journal of Physiology-endocrinology and Metabolism, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Stimulation by 2-deoxy-\u003cscp\u003ed\u003c/scp\u003e-glucose tetraacetates of hormonal secretion from the perfused rat pancreas","attachmentId":112539912,"attachmentType":"pdf","work_url":"https://www.academia.edu/116399350/Stimulation_by_2_deoxy_scp_d_scp_glucose_tetraacetates_of_hormonal_secretion_from_the_perfused_rat_pancreas","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/116399350/Stimulation_by_2_deoxy_scp_d_scp_glucose_tetraacetates_of_hormonal_secretion_from_the_perfused_rat_pancreas"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="21" data-entity-id="25006829" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/25006829/Interactions_of_Islet_Hormones_with_Acetylcholine_in_the_Isolated_Rat_Pancreas">Interactions of Islet Hormones with Acetylcholine in the Isolated Rat Pancreas</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33403535" href="https://independent.academia.edu/JaipaulSingh">Jaipaul Singh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Peptides, 1997</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Interactions of Islet Hormones with Acetylcholine in the Isolated Rat Pancreas","attachmentId":45331971,"attachmentType":"pdf","work_url":"https://www.academia.edu/25006829/Interactions_of_Islet_Hormones_with_Acetylcholine_in_the_Isolated_Rat_Pancreas","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/25006829/Interactions_of_Islet_Hormones_with_Acetylcholine_in_the_Isolated_Rat_Pancreas"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="22" data-entity-id="109260330" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/109260330/Effect_of_Muscimol_on_Glucose_stimulated_Somatostatin_and_Insulin_Release_from_the_Isolated_Perfused_Rat_Pancreas">Effect of Muscimol on Glucose-stimulated Somatostatin and Insulin Release from the Isolated, Perfused Rat Pancreas</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38336942" href="https://independent.academia.edu/SorensonR">Robert Sorenson</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Diabetes, 1981</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effect of Muscimol on Glucose-stimulated Somatostatin and Insulin Release from the Isolated, Perfused Rat Pancreas","attachmentId":107438980,"attachmentType":"pdf","work_url":"https://www.academia.edu/109260330/Effect_of_Muscimol_on_Glucose_stimulated_Somatostatin_and_Insulin_Release_from_the_Isolated_Perfused_Rat_Pancreas","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/109260330/Effect_of_Muscimol_on_Glucose_stimulated_Somatostatin_and_Insulin_Release_from_the_Isolated_Perfused_Rat_Pancreas"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="23" data-entity-id="102133235" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/102133235/Triggering_and_Augmentation_Mechanisms_Granule_Pools_and_Biphasic_Insulin_Secretion">Triggering and Augmentation Mechanisms, Granule Pools, and Biphasic Insulin Secretion</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="219290598" href="https://independent.academia.edu/StephenDaniel43">Stephen Daniel</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Diabetes, 2002</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Triggering and Augmentation Mechanisms, Granule Pools, and Biphasic Insulin Secretion","attachmentId":102477663,"attachmentType":"pdf","work_url":"https://www.academia.edu/102133235/Triggering_and_Augmentation_Mechanisms_Granule_Pools_and_Biphasic_Insulin_Secretion","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/102133235/Triggering_and_Augmentation_Mechanisms_Granule_Pools_and_Biphasic_Insulin_Secretion"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="24" data-entity-id="22885488" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/22885488/G_o_Represses_Insulin_Secretion_by_Reducing_Vesicular_Docking_in_Pancreatic_Cells">G o Represses Insulin Secretion by Reducing Vesicular Docking in Pancreatic -Cells</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="44562961" href="https://uca-ar.academia.edu/LutzBirnbaumer">Lutz Birnbaumer</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Diabetes, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"G o Represses Insulin Secretion by Reducing Vesicular Docking in Pancreatic -Cells","attachmentId":43426849,"attachmentType":"pdf","work_url":"https://www.academia.edu/22885488/G_o_Represses_Insulin_Secretion_by_Reducing_Vesicular_Docking_in_Pancreatic_Cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/22885488/G_o_Represses_Insulin_Secretion_by_Reducing_Vesicular_Docking_in_Pancreatic_Cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related topics</h2><div class="ds-research-interests--pills-container"><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="154" href="https://www.academia.edu/Documents/in/Endocrinology">Endocrinology</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="4987" href="https://www.academia.edu/Documents/in/Kinetics">Kinetics</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="7710" href="https://www.academia.edu/Documents/in/Biology">Biology</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="47884" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="54999" href="https://www.academia.edu/Documents/in/Somatostatin">Somatostatin</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="65390" href="https://www.academia.edu/Documents/in/Internal_Medicine">Internal Medicine</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="71289" href="https://www.academia.edu/Documents/in/Glucose">Glucose</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="71400" href="https://www.academia.edu/Documents/in/Insulin">Insulin</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="176525" href="https://www.academia.edu/Documents/in/Biochemical">Biochemical</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="260118" href="https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES">CHEMICAL SCIENCES</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="303924" href="https://www.academia.edu/Documents/in/Promethazine">Promethazine</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="375054" href="https://www.academia.edu/Documents/in/Rats">Rats</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="555007" href="https://www.academia.edu/Documents/in/Receptor">Receptor</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="557707" href="https://www.academia.edu/Documents/in/Exocytosis">Exocytosis</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="586877" href="https://www.academia.edu/Documents/in/Arvicolinae">Arvicolinae</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="1705044" href="https://www.academia.edu/Documents/in/islets_of_Langerhans">islets of Langerhans</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="1942933" href="https://www.academia.edu/Documents/in/Somatostatin_Receptor">Somatostatin Receptor</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="3763225" href="https://www.academia.edu/Documents/in/Medical_and_Health_Sciences">Medical and Health Sciences</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="3881526" href="https://www.academia.edu/Documents/in/In_Vitro_Techniques">In Vitro Techniques</a></div></div></div></div></div><div class="footer--content"><ul class="footer--main-links hide-on-mobile"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a rel="nofollow" href="https://medium.com/academia">Blog</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px; position: relative; bottom: -1px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a href="https://support.academia.edu/"><svg style="width: 12px; height: 12px; position: relative; bottom: -1px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer--research-interests"><li>Find new research papers in:</li><li><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul><ul class="footer--legal-links hide-on-mobile"><li><a href="https://www.academia.edu/terms">Terms</a></li><li><a href="https://www.academia.edu/privacy">Privacy</a></li><li><a href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div> </body> </html>