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Deuteration and Macromolecular Crystallisation (DEMAX) | ESS

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breadcrumb__item--current breadcrumb__item--disabled">DEMAX</a> </nav> <h1 class="content-page-title">Deuteration and Macromolecular Crystallisation (DEMAX)</h1> <div class="page__hero"> <picture> <source srcset="/sites/default/files/styles/page_image/public/images/hero/2024-02/20171012-292-43-RE_Full%20internal%20use%20_%20for%20all%20internal%20channels.jpg?itok=TYG81KYl 1x" media="(min-width: 576px)" type="image/jpeg" width="1289" height="793"/> <img class="image" loading="lazy" src="/sites/default/files/styles/page_image/public/images/hero/2024-02/20171012-292-43-RE_Full%20internal%20use%20_%20for%20all%20internal%20channels.jpg?itok=TYG81KYl" width="1289" height="793" alt="Zoe F" /> </picture> </div> <div class="content-page-sections"> <section class="layout-section layout-section--primary layout-section--one-columns"> <div class="layout-section__row"> <section class="section section--text"> <h3>The聽Deuteration &amp;聽Macromolecular聽Crystallization (DEMAX) team at ESS聽supports the neutron research community by providing deuterated molecules and support for protein crystallography.聽</h3><p>Support from DEMAX is relevant to researchers in the fields of life science, soft matter, chemistry and biomaterials. The most commonly user neutron scattering techniques that rely on DEMAX support include:聽small angle neutron scattering (SANS), neutron reflectometry (NR), neutron protein crystallography (NPX), spectroscopy, spin-echo, and powder diffraction.</p><p>Although ESS is not yet providing neutron beam time, scientists can already now submit proposals for deuterated materials for use in their neutron experiments at other facilities. Access is based upon peer review of proposals and scientific merit and is currently not limited to ESS member countries. Open proposal calls are advertised on the ESS webpages, LinkedIn, and at the <a href="//deuteration.org">Deuteration Network website</a>.聽</p> </section> </div> </section> <section class="layout-section layout-section--primary layout-section--one-columns"> <div class="layout-section__row"> <section class="section section--text"> <hr /><div data-entity-type="block_content" data-entity-uuid="cce9956f-1631-4d2b-a218-e1ef1590ec91" data-embed-button="block_browse" data-entity-embed-display="view_mode:block_content.full" data-langcode="en" data-entity-embed-display-settings="[]" class="embedded-entity embedded-block-content embedded-block-content-tabs embedded-block-content-tabs--full"> <div id="tabs-914" class="tabs "><ul class="tabs__nav"><li class="tabs__nav-item"><a class="tabs__nav-link" href="#what-we-offer"> What we offer </a></li> <li class="tabs__nav-item"><a class="tabs__nav-link" href="#team-contact"> Team &amp; Contact </a></li> </ul><div class="tabs__pane" id="what-we-offer"> <p>The team provides three pillars of support: chemical deuteration, biological deuteration (including yeast-derived lipids), and protein crystallisation.聽</p><p>For biodeuteration, we support cell cultures of <em>E. coli</em>, yeast, and microalgae under normal and deuterated conditions. From these living systems we can extract a variety of deuterated components for downs</p> <div data-entity-type="block_content" data-entity-uuid="b1c15f0c-d819-458c-9edd-41ac08574970" data-embed-button="block_create" data-entity-embed-display="view_mode:block_content.full" class="align-right embedded-entity embedded-block-content embedded-block-content-downloads embedded-block-content-downloads--full" data-langcode="en" data-entity-embed-display-settings="[]"> <div class="downloads"> <header class="downloads__header"><h4 class="downloads__header-title">Download</h4> </header><ul class="downloads__list"><li class="downloads__list-item"><a href="/sites/default/files/files/document/2024-02/DEMAX-product-catalogue_August2023.pdf" class="downloads__list-link">DEMAX Product Catalogue</a><span class="downloads__list-type">3.88 MB pdf</span></li> </ul><a href="/block/915/download" class="button button--primary button--square button--block">Download all</a></div> </div> <p>tream use: plasmid DNA, recombinant proteins, lipids (total, phospholipid), and soluble extracts. For chemical deuteration we do organic synthesis of a range of small molecules/monomers, lipids (POPC, SOPC, POPE, etc.), surfactants, detergents, and also a range of novel molecules. Please look at our <a href="/sites/default/files/files/document/2024-02/DEMAX-product-catalogue_August2023.pdf" data-entity-type="file" data-entity-uuid="83697a61-c3cf-48a2-9034-4731b283b130" data-entity-substitution="file" rel="noopener" target="_blank">Product Catalogue</a> for additional details. For protein crystallography, we support the full workflow: from initial screening to optimisation and testing with X-rays.聽</p> <div data-entity-type="media" data-entity-uuid="2bd2762b-b64b-4c44-8914-b5ad34955233" data-embed-button="media" data-entity-embed-display="view_mode:media.custom" data-langcode="en" data-entity-embed-display-settings="[]" class="embedded-entity embedded-media embedded-media-image embedded-media-image--custom"> <div class="media media-image media-image--custom"> <div class="media__content"> <img class="image" src="/sites/default/files/styles/custom/public/images/media/2024-02/DEMAX%20Figure%202.jpg?itok=jFft9YiI" width="1495" height="1989" alt="DEMAX platform" loading="lazy" /></div> <footer class="media__footer"></footer></div> </div> <div><div><div><div>聽</div></div></div></div> </div> <div class="tabs__pane" id="team-contact"> <p>For more information on the team, services, and collaboration opportunities, please reach out the relevant subject matter expert below, or drop us a line on our shared mailbox:聽<a href="mailto:demax@ess.eu"><strong>demax@ess.eu</strong></a></p><p>The DEMAX core team at ESS is:</p><ul class="list"><li><strong>Zo毛 Fisher</strong>, specialising in biological deuteration and protein crystallisation.<br /><a href="mailto:zoe.fisher@ess.eu">zoe.fisher@ess.eu</a>聽聽</li></ul><div data-entity-type="media" data-entity-uuid="d068119b-55cc-4b3b-a7dc-53c173c12834" data-embed-button="media" data-entity-embed-display="view_mode:media.portrait_small" data-langcode="en" data-entity-embed-display-settings="[]" class="embedded-entity embedded-media embedded-media-image embedded-media-image--portrait-small"> <div class="media media-image media-image--portrait-small"> <div class="media__content"> <picture><source srcset="/sites/default/files/styles/portrait/public/images/media/2024-02/DEMAX%20ZF.jpeg?itok=DYLRkSpS 1x" media="(min-width: 576px)" type="image/jpeg" width="660" height="660"></source><img class="image" loading="eager" src="/sites/default/files/styles/portrait/public/images/media/2024-02/DEMAX%20ZF.jpeg?itok=DYLRkSpS" width="660" height="660" alt="Zoe Fisher" /></picture></div> <footer class="media__footer"></footer></div> </div> <ul class="list"><li><strong>Hanna Wacklin-Knecht</strong>, specialising in membranes, bilayers and lipids.<br /><a href="mailto:hanna.wacklin-knecht@ess.eu">hanna.wacklin-knecht@ess.eu</a>聽聽</li></ul><div data-entity-type="media" data-entity-uuid="da875831-fd65-4c65-82d4-5c765dfd80ee" data-embed-button="media" data-entity-embed-display="view_mode:media.portrait_small" data-langcode="en" data-entity-embed-display-settings="[]" class="embedded-entity embedded-media embedded-media-image embedded-media-image--portrait-small"> <div class="media media-image media-image--portrait-small"> <div class="media__content"> <picture><source srcset="/sites/default/files/styles/portrait/public/images/media/2024-02/DEMAX%20HWK.jpeg?itok=cxcaOZi- 1x" media="(min-width: 576px)" type="image/jpeg" width="660" height="807"></source><img class="image" loading="eager" src="/sites/default/files/styles/portrait/public/images/media/2024-02/DEMAX%20HWK.jpeg?itok=cxcaOZi-" width="660" height="807" alt="Hanna Wacklin-Knecht" /></picture></div> <footer class="media__footer"></footer></div> </div> <ul class="list"><li><strong>Anna Leung</strong>, specialising in deuteration chemistry and organic synthesis.<br /><a href="mailto:anna.leung@ess.eu">anna.leung@ess.eu</a>聽聽</li></ul><div data-entity-type="media" data-entity-uuid="fdb300ab-8a0d-41c4-ac60-eba0e26943b5" data-embed-button="media" data-entity-embed-display="view_mode:media.portrait_small" data-langcode="en" data-entity-embed-display-settings="[]" class="embedded-entity embedded-media embedded-media-image embedded-media-image--portrait-small"> <div class="media media-image media-image--portrait-small"> <div class="media__content"> <picture><source srcset="/sites/default/files/styles/portrait/public/images/media/2024-02/DEMAX%20AL.jpeg?itok=jZF_Mf3S 1x" media="(min-width: 576px)" type="image/jpeg" width="660" height="745"></source><img class="image" loading="eager" src="/sites/default/files/styles/portrait/public/images/media/2024-02/DEMAX%20AL.jpeg?itok=jZF_Mf3S" width="660" height="745" alt="Anna Leung" /></picture></div> <footer class="media__footer"></footer></div> </div> <ul class="list"><li><strong>Jia-Fei Poo</strong>, specialising in deuteration chemistry and organic synthesis.<br /><a href="mailto:jia-fei.poon@ess.eu">jia-fei.poon@ess.eu</a>聽聽</li></ul><div data-entity-type="media" data-entity-uuid="f5f50c8b-af27-426b-969b-5ccc5b23e210" data-embed-button="media" data-entity-embed-display="view_mode:media.portrait_small" data-langcode="en" data-entity-embed-display-settings="[]" class="embedded-entity embedded-media embedded-media-image embedded-media-image--portrait-small"> <div class="media media-image media-image--portrait-small"> <div class="media__content"> <picture><source srcset="/sites/default/files/styles/portrait/public/images/media/2024-02/DEMAX%20JFP.jpeg?itok=NBzNrq_K 1x" media="(min-width: 576px)" type="image/jpeg" width="660" height="878"></source><img class="image" loading="eager" src="/sites/default/files/styles/portrait/public/images/media/2024-02/DEMAX%20JFP.jpeg?itok=NBzNrq_K" width="660" height="878" alt="Jia-Fei Poo" /></picture></div> <footer class="media__footer"></footer></div> </div> <p>Alongside the core team, two Lund University postdoctoral researchers work in our labs on various deuteration projects. In addition, we work closely with the <a href="https://www.lp3.lu.se/">Lund Protein Production Platform (LP3)</a> and have a Swedish in-kind collaboration on receiving Deuteration Lab Services related to our user program.</p> </div> </div> </div> <div data-entity-type="block_content" data-entity-uuid="7f732303-cae8-4ee0-91c1-a7b6312d046f" data-embed-button="block_create" data-entity-embed-display="view_mode:block_content.full" data-langcode="en" data-entity-embed-display-settings="[]" class="embedded-entity embedded-block-content embedded-block-content-puff embedded-block-content-puff--full"><div class="puff-grid"><div class="puff-grid-small"> <div class="card card--push"> <div class="card__block"> <h3 class="card__title"><a href="/science-using-neutrons/life-science-soft-condensed-matter"> <span>Life Science &amp; Soft Condensed Matter</span> </a></h3> <p class="card__text">ESS will enable some areas of life science, medical and pharmacological research to investigate with neutrons 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