Vaccines and Infectious Diseases

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aria-hidden="false">Open menu</span> </button> <a href="https://www.360biolabs.com/contact/" class="button has-gradient button-contact"> <span>Connect With Us</span> </a> </div> </div> </div> </div> </header> <main id="main-content"> <section class="content-block block-services-hero has-amber-fair-bg"> <div class="container is-default"> <div class="column-content" data-neruda-anim="fade-in" data-neruda-anim-duration="1s" data-neruda-anim-delay=".25s"> <h1>Vaccines and Infectious Diseases</h1> <div class="intro-content"> <p>360biolabs possesses significant expertise in the field of vaccine and infectious disease research and development. Our services encompass a diverse range of virological, immunological, and molecular assays that support the development of vaccines, viral vectors, and therapeutics aimed at treating or preventing diseases.</p> </div> </div> </div> <img src="https://www.360biolabs.com/wp-content/themes/cc-360biolabs/assets/images/hero-shape.svg" alt="Decorative image" class="bottom-decoration" data-neruda-anim="hero-shape"> <div class="icon-bg" style="background-image:url('https://www.360biolabs.com/wp-content/themes/cc-360biolabs/assets/images/icons-library/icon-virology-default.svg')" data-neruda-anim="fade-left"></div> </section> <div class="services-page-anchor"> <div class="button-page-scroll-container"> <a href="#page-content" class="button-page-scroll"> <span aria-hidden="false">Scroll to page content</span> </a> </div> <a id="page-content"></a> </div> <section class="content-block block-pill-image-text"> <div class="container is-wide"> <div class="columns"> <div class="column-content"> <div class="inner-padding"> <h2>Experience in <br /> Infectious diseases:</h2> <div class="features-container"> <div class="feature" style="background-image:url('https://www.360biolabs.com/wp-content/themes/cc-360biolabs/assets/images/icons-library/icon-measuring-cylinder-circle.svg');"> <h3>Extensive Experience </h3> <p>360biolabs infectious diseases and virology team have > 20 years of experience in developing assays, culturing viruses, and supporting vaccine clinical studies.</p> </div> <div class="feature" style="background-image:url('https://www.360biolabs.com/wp-content/themes/cc-360biolabs/assets/images/icons-library/icon-science-driven-circle.svg');"> <h3>Custom Assay Solutions</h3> <p>When we combine our virology, immunology, and molecular biology capabilities, we can support any endpoint required for vaccine or antiviral clinical studies.</p> </div> <div class="feature" style="background-image:url('https://www.360biolabs.com/wp-content/themes/cc-360biolabs/assets/images/icons-library/icon-lab-coat-circle.svg');"> <h3>State-of-the-art Facility</h3> <p>Our Australian facilities in Melbourne and Brisbane have biological safety level (BSL) 2 and 3 laboratories. </p> </div> </div> </div> </div> <div class="column-image"> <div class="image-container" > <figure> <img width="1920" height="1280" src="https://www.360biolabs.com/wp-content/uploads/Virology.webp" class="attachment-full size-full" alt="Two scientists reading viral plaques from a plaque assay" decoding="async" fetchpriority="high" srcset="https://www.360biolabs.com/wp-content/uploads/Virology.webp 1920w, https://www.360biolabs.com/wp-content/uploads/Virology-600x400.webp 600w, https://www.360biolabs.com/wp-content/uploads/Virology-1400x933.webp 1400w, https://www.360biolabs.com/wp-content/uploads/Virology-768x512.webp 768w, https://www.360biolabs.com/wp-content/uploads/Virology-1536x1024.webp 1536w" sizes="(max-width: 1920px) 100vw, 1920px" /> </figure> <div class="shape has-cyan-fair-bg" ></div> </div> <div class="section-action"> <a href="https://www.360biolabs.com/contact/" target="_self">Make the right bioanalytical method selection with our help</a> </div> </div> </div> </div> </section> <section class="content-block block-grid-large"> <div class="container is-default"> <h2>360biolabs Bioanalytical Solutions</h2> <h3 style="background-image:url('https://www.360biolabs.com/wp-content/themes/cc-360biolabs/assets/images/icons-library/icon-viral-culture-default.svg')">Infectious disease and<br /> virological based services</h3> <div class="features-container"> <div class="feature-card"> <h4>Culture based assays</h4> <p>Cell culture is used to isolate, identify, and quantify specific viruses. This laboratory technique is particularly critical in helping understand the efficacy and safety of antiviral drugs and vaccines.</p> <ul> <li>Qualitative culture (flask)</li> <li>Quantitative culture (TCID50 or Plaque Assay)</li> </ul> </div> <div class="feature-card"> <h4>Neutralisation</h4> <p>Viral neutralisation assays are key in determining the ability of antibodies to inhibit the infectivity of a virus. These assays can also be used to characterise the immune response to vaccines.</p> <ul> <li>Plaque Reduction鈥∟eutralisation Test (PRNT)</li> <li>Microneutralisation (MNT)</li> <li>Focus Reduction鈥∟eutralisation Test (FRNT)</li> </ul> </div> <div class="feature-card"> <h4>ELISpot</h4> <p>Enzyme-linked immunosorbent spot (ELISpot) measures the frequency of antigen-specific cells by measuring the number of cytokine-secreting cells in PBMCs at a single-cell level.</p> <ul> <li>Diverse array of cytokines</li> <li>T-cells</li> <li>B-cells</li> </ul> </div> <div class="feature-card"> <h4>Hemagglutination鈥╥nhibition (HAI)</h4> <p>Hemagglutination inhibition (HAI) is an assay used in the detection and/or quantification of antibodies to a viral infection.</p> <ul> <li>Influenza HAI assays</li> </ul> </div> <div class="feature-card"> <h4>Cellular Responses</h4> <p>Inducing T-cell-mediated immunity is pivotal in vaccine development. Assessing this response via immunophenotyping is an important part of establishing the effectiveness of a vaccine.</p> <ul> <li>Immunophenotyping</li> <li>Intracellular cytokine staining (ICS)</li> </ul> </div> <div class="feature-card"> <h4>Molecular assays</h4> <p>Molecular assays qualitatively or quantitatively measure the presence and amount of a target entity and assess gene expression to identify signatures and predictors of vaccine-induced specific antibody and T-cell responses.</p> <ul> <li>Real-time quantitative PCR (qPCR)</li> <li>Gene expression via qPCR or dPCR</li> <li>Mutation detection</li> <li>Gene panels (array cards)</li> <li>Pathogen detection</li> <li>Viral vector titres and shedding</li> </ul> </div> <div class="feature-card"> <h4>Biomarkers</h4> <p>Immune-based biomarker assays are widely used to assess vaccine responses. Detection and measurement of the presence of vaccine-induced antibodies to viral, bacterial, toxin antigen targets, cytokines, or other key biomarkers in matrices such as serum, plasma, mucosal, and saliva are available in single-plex to multiplex format.</p> <ul> <li>MSD-ECL</li> <li>Bead-based luminescence</li> <li>Simoa, Single Molecule Array</li> <li>Absorbance-based</li> </ul> </div> <div class="feature-card"> <h4>Immunoassays</h4> <p>Antibodies play a key role in the immune response by recognising and binding to specific antigens, such as bacteria, viruses, and toxins.</p> <ul> <li>Vaccine-specific ELISAs</li> <li>IgG, IgM, IgA serology testing</li> </ul> </div> <div class="feature-card"> <h4>PBMC Isolation</h4> <p>Peripheral Blood Mononuclear Cells (PBMCs) are key in vaccine research for evaluating memory T cell responses, B cell responses, cytokine profiling, and assessment of cellular immunity to candidate vaccines.</p> <ul> <li>Ficoll</li> <li>SepMate</li> <li>CPT</li> </ul> </div> </div> <div class="section-action-text"> <p>If you have questions on how our team can support you with our vaccines and infectious disease capabilities, connect with us.</p> </div> <div class="section-actions"> <a href="https://www.360biolabs.com/contact/" target="_self" class="button"> <span>Discuss Clinical Study</span> </a> <a href="https://www.360biolabs.com/australian-advantage/" target="_self" class="button is-outlined"> <span>Australian Advantage</span> </a> </div> </div> </section> <section class="content-block block-virology" id="virology"> <div class="container"> <h2>Virology</h2> <div class="services-container"> <div class="service-card"> <h3 style="background-image:url('https://www.360biolabs.com/wp-content/themes/cc-360biolabs/assets/images/icons-library/icon-virology-default.svg')">Infectious Diseases & Virology</h3> <p>A southern hemisphere location offers advantages for conducting clinical trials on respiratory viruses. Transitioning from the northern to the southern hemisphere season can potentially shorten a clinical study timeline by six months. BSL2 and BSL3 laboratories enable the support of a broad spectrum of vaccines aimed at targeting viruses, including:</p> <ul> <li>Adenovirus</li> <li>Chikungunya</li> <li>EV71</li> <li>HSV</li> <li>Measles/rubella</li> <li>Poxvirus</li> <li>RSV</li> <li>SARS-CoV-2</li> <li>Seasonal influenza</li> <li>VZV</li> <li>Zika</li> </ul> </div> <div class="service-card"> <h3 style="background-image:url('https://www.360biolabs.com/wp-content/themes/cc-360biolabs/assets/images/icons-library/icon-vaccines-default.svg')">Other Vaccines</h3> <p>To explore vaccines aimed at bacterial pathogens and allergen-specific immunotherapy, a thorough evaluation of diverse immunological parameters is essential. This necessitates access to a laboratory equipped with a comprehensive immunology suite and staffed by an experienced team.</p> <ul> <li>Peanut allergy</li> <li>Pertussis</li> <li>Malaria</li> </ul> </div> </div> </div> </section> <section class="content-block block-text-hero-image has-azure-fair-bg"> <div class="container is-default"> <h2 class="is-centered">BSL2 & BSL3 Laboratories</h2> <div class="section-content"> <p>Our BSL3 (Biosafety Level 3) laboratory is a specialised facility designed to handle and conduct research on pathogens that can cause serious or potentially lethal diseases in humans. Our staff are trained to study dangerous pathogens under controlled conditions, participate in the development of countermeasures against emerging infectious diseases, and contribute to global efforts in disease prevention.</p> </div> </div> <div class="hero-image content-block has-half-bg"> <div class="container is-default"> <figure> <img width="793" height="512" src="https://www.360biolabs.com/wp-content/uploads/PC3-lab_virology-2.webp" class="attachment-full size-full" alt="Scientist conducting cell culture in Biosafety Level 3 laboratory (BSL-3) or Physical Containment 3 (PC3) laboratory" decoding="async" srcset="https://www.360biolabs.com/wp-content/uploads/PC3-lab_virology-2.webp 793w, https://www.360biolabs.com/wp-content/uploads/PC3-lab_virology-2-600x387.webp 600w, https://www.360biolabs.com/wp-content/uploads/PC3-lab_virology-2-768x496.webp 768w" sizes="(max-width: 793px) 100vw, 793px" /> </figure> </div> </div> </section> <section class="content-block block-related-content"> <div class="container"> <h2 class="is-centered">Related Content</h2> <div class="columns"> <div class="column"> <figure> <img width="600" height="400" src="https://www.360biolabs.com/wp-content/uploads/Flow-cytometry_9512-600x400.webp" class="attachment-medium size-medium" alt="Scientist reading a sample of our Canto II flow cytometer" decoding="async" srcset="https://www.360biolabs.com/wp-content/uploads/Flow-cytometry_9512-600x400.webp 600w, https://www.360biolabs.com/wp-content/uploads/Flow-cytometry_9512-1400x933.webp 1400w, https://www.360biolabs.com/wp-content/uploads/Flow-cytometry_9512-768x512.webp 768w, https://www.360biolabs.com/wp-content/uploads/Flow-cytometry_9512-1536x1024.webp 1536w, https://www.360biolabs.com/wp-content/uploads/Flow-cytometry_9512.webp 1920w" sizes="(max-width: 600px) 100vw, 600px" /> </figure> <div class="text-container"> <h3>Flow Cytometry</h3> <div class="column-blurb"> <p>Using high-parameter single-cell analysis, flow cytometry can identify granular changes in response to a therapeutic.</p> </div> <p class="column-action"> <a href="https://www.360biolabs.com/flow-cytometry/"> Learn more</a> </p> </div> </div> <div class="column"> <figure> <img width="600" height="400" src="https://www.360biolabs.com/wp-content/uploads/Photo-Feature_Biomarkers-detail-600x400.webp" class="attachment-medium size-medium" alt="Pipetting for accurate, precise and robust sample analysis" decoding="async" loading="lazy" srcset="https://www.360biolabs.com/wp-content/uploads/Photo-Feature_Biomarkers-detail-600x400.webp 600w, https://www.360biolabs.com/wp-content/uploads/Photo-Feature_Biomarkers-detail-1400x933.webp 1400w, https://www.360biolabs.com/wp-content/uploads/Photo-Feature_Biomarkers-detail-768x512.webp 768w, https://www.360biolabs.com/wp-content/uploads/Photo-Feature_Biomarkers-detail-1536x1024.webp 1536w, https://www.360biolabs.com/wp-content/uploads/Photo-Feature_Biomarkers-detail.webp 1920w" sizes="(max-width: 600px) 100vw, 600px" /> </figure> <div class="text-container"> <h3>Biomarkers</h3> <div class="column-blurb"> <p>Biomarker analysis enables you to assess a therapeutic鈥檚 efficacy, safety, and mechanism of action during the drug development process.</p> </div> <p class="column-action"> <a href="https://www.360biolabs.com/biomarkers/"> Learn more</a> </p> </div> </div> <div class="column"> <figure> <img width="600" height="400" src="https://www.360biolabs.com/wp-content/uploads/PCR_MCP_6884-1-600x400.webp" class="attachment-medium size-medium" alt="High throughput extraction of RNA via Kingfisher automated extractor prior to amplification via polymerase chain reaction (PCR)聽on a ThermoFisher Quant Studio 7" decoding="async" loading="lazy" srcset="https://www.360biolabs.com/wp-content/uploads/PCR_MCP_6884-1-600x400.webp 600w, https://www.360biolabs.com/wp-content/uploads/PCR_MCP_6884-1-1400x933.webp 1400w, https://www.360biolabs.com/wp-content/uploads/PCR_MCP_6884-1-768x512.webp 768w, https://www.360biolabs.com/wp-content/uploads/PCR_MCP_6884-1-1536x1024.webp 1536w, https://www.360biolabs.com/wp-content/uploads/PCR_MCP_6884-1.webp 1772w" sizes="(max-width: 600px) 100vw, 600px" /> </figure> <div class="text-container"> <h3>Molecular Assays</h3> <div class="column-blurb"> <p>We leverage Real-time Polymerase Chain Reaction, Quantitative PCR, and Digital PCR as part of our extensive molecular technology suite.</p> </div> <p class="column-action"> <a href="https://www.360biolabs.com/molecular-assays/"> Learn more</a> </p> </div> </div> </div> </div> </section> </main> <section class="block-footer-cta"> <div class="container is-default"> <div class="columns"> <div class="column-text"> <p>Enabling future medicine together. 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Vaccines and Infectious Diseases · 360biolabs